Preferred Label : Nanoparticles Encapsulating TLR7 Agonist 1v270 MBS8;
NCIt synonyms : MBS8(1V270); TLR7 Agonist 1v270-containing Micelles MBS8; DOPE-PEG2000/1v270 Micelles MBS8;
NCIt definition : A micelle nanoparticle formulation composed of the Toll-Like receptor 7 (TLR7) agonist
phospholipid conjugate 1v270 encapsulated within 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
(DOPE)-polyethylene glycol (PEG)-2000, with potential immunostimulating activity.
Upon intravenous administration of the nanoparticles encapsulating TLR7 agonist 1v270
MBS8, the TLR7 agonist targets, binds to and activates TLR7, thereby stimulating dendritic
cells (DCs) and neutrophils, and enhancing natural killer cell (NK) cytotoxicity.
This activation results in the production of pro-inflammatory cytokines, including
interferon alpha. MBS8 may activate cytotoxic T-lymphocyte (CTL)-mediated anti-tumor
immune responses leading to tumor cell lysis. In addition, MBS8 is able to stimulate
immune memory T-cells to further recognize and eliminate cancer cells. TLR7 is a member
of the TLR family, which plays a fundamental role in pathogen recognition and the
activation of innate immunity. The micelle formulation was engineered to reduce systemic
cytokine production which may lower systemic toxicity. production which may lower
systemic toxicity.;
Molecule name : MBS 8; MBS-8;
NCI Metathesaurus CUI : CL1663323;
Origin ID : C180692;
UMLS CUI : C5556565;
Semantic type(s)
- concept_is_in_subset
- has_target
