Preferred Label : TLR7 Agonist ANA773 Tosylate;
NCIt synonyms : Toll-Like Receptor 7 Agonist ANA773 Tosylate; ANA773 Tosylate;
NCIt definition : The tosylate salt form of ANA773, a Toll-Like Receptor 7 (TLR7) agonist prodrug with
potential immunostimulating activity. Upon oral administration, ANA773 is metabolized
into its active form that binds to and activates TLR7, thereby stimulating dendritic
cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results
in the production of proinflammatory cytokines, including interferon alpha, and enhanced
antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family,
which plays a fundamental role in pathogen recognition and activation of innate immunity.;
NCI Metathesaurus CUI : CL428165;
Origin ID : C95699;
UMLS CUI : C2987340;
Semantic type(s)
- concept_is_in_subset
- has_target
