Preferred Label : TLR7 Agonist APR003;
NCIt definition : An orally bioavailable, small molecule Toll-Like Receptor 7 (TLR7) agonist, with potential
immunostimulating activity. Upon oral administration, TLR7 agonist APR003 targets,
binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing
natural killer cell (NK) cytotoxicity. This activation results in the production of
proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent
cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which plays a fundamental
role in pathogen recognition and activation of innate immunity. APR003 is localized
in the gastrointestinal (GI) tract and liver, which may promote local immune responses
and local tumor eradication and prevent systemic adverse effects.;
Molecule name : APR-003; APR 003;
NCI Metathesaurus CUI : CL1648138;
Origin ID : C178436;
UMLS CUI : C5555031;
Semantic type(s)
- concept_is_in_subset
- has_target
