Preferred Label : TLR7 Agonist LHC165;
NCIt related terms : LHC-165;
NCIt definition : A benzonapthyridine Toll-like receptor (TLR) 7 agonist that is adsorbed to aluminum
hydroxide with immunostimulating and potential antitumor activities. Upon intratumoral
administration of TLR7 agonist LHC165, the agent is slowly released and targets, binds
to and activates TLR7. This may trigger, in addition to other possible responses,
the activation of cluster of differentiation (CD) 8 T cells and natural killer (NK)
cells, the blockage of the suppressive function of regulatory T cells (Tregs), and
the production of interferon alpha (IFNa). TLR7 is a member of the TLR family, which
plays a fundamental role in pathogen recognition and activation of innate immunity.;
UNII : RD02U4QLM1;
CAS number : 1258595-14-0;
Molecule name : LHC-165; LHC 165;
NCI Metathesaurus CUI : CL971618;
Origin ID : C166362;
UMLS CUI : C5237924;
Semantic type(s)
- concept_is_in_subset
- has_target
