Preferred Label : Guretolimod;
NCIt synonyms : TLR7 Agonist DSP-0509; Toll-like Receptor 7 Agonist DSP-0509; (((4-((2-Amino-4-(((3s)-1-hydroxyhexan-3-yl)amino)-6-methylpyrimidin-5-yl)methyl)-3-
methoxyphenyl)methyl)(2,2,2-trifluoroethyl)amino)acetic Acid;
NCIt definition : A synthetic, small molecule, toll-like receptor (TLR) 7 agonist, with potential immunostimulatory
and antineoplastic activities. Upon intravenous administration, guretolimod activates
TLR7, resulting in type I interferon secretion and activation of cytotoxic T-lymphocyte
(CTL)-mediated anti-tumor immune responses. TLR7 is a member of the TLR family, which
plays a fundamental role in pathogen recognition and activation of innate immunity.;
UNII : 2UG29YVL56;
CAS number : 1488364-57-3;
Molecule name : DSP 0509; DSP-0509;
NCI Metathesaurus CUI : CL554427;
Origin ID : C153314;
UMLS CUI : C5554548;
Semantic type(s)
- concept_is_in_subset
- has_target
