NCIt definition : A recombinant, human Fc-inert monoclonal antibody targeting lymphocyte-activation
gene 3 protein (LAG-3; LAG3), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon intravenous administration, monoclonal antibody Sym022 binds to human
LAG-3 and blocks the interaction between LAG-3 and major histocompatibility complex
class II (MHCII) molecules on the surface of antigen-presenting cells (APCs) and tumor
cells. This prevents the negative regulation of T-cell activity that occurs via LAG-3-MHCII
binding and enhances a cytotoxic T-lymphocyte (CTL)-mediated immune response against
tumor cells. Additionally, Sym022 decreases LAG-3 surface levels through internalization
and shredding. LAG-3 plays a key role in the activation of T-cells and natural killer
(NK) cells.;
UNII : 7TQ52FVC2L;
CAS number : 2250088-52-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2250088-52-7
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