BDNF/NT-3 Growth Factors Receptor

Preferred Label : BDNF/NT-3 Growth Factors Receptor;

NCIt synonyms : NTRK2; GP145-TRKB; TRKB Tyrosine Kinase; TRKB; Neurotrophic Tyrosine Kinase Receptor Type 2; Neurotrophic Tyrosine Kinase Receptor Type-2; Tropomyosin-Related Kinase B; EC 2.7.10.1;

NCIt definition : BDNF/NT-3 growth factors receptor (822 aa, 92 kDa) is encoded by the human NTRK2 gene. This protein plays a role in growth factor-dependent signaling, tyrosine phosphorylation and nervous system development.;

NCIt note : BDNF/NT-3 growth factors receptor a type I membrane receptor for BDNF, NTF3, and NTF4/5, but not NGF. (UniProt);

Details

Origin ID

C33983;

UMLS CUI

C3853697;

OMIM relation
- Neurotrophic tyrosine kinase, receptor, type 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- tropomyosin-related kinase-B, human [MeSH concept]
- tropomyosin-related kinase-B, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- NTRK2 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- MAPK Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Neural Development [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Cabozantinib [NCIt concept]
- Cabozantinib S-malate [NCIt concept]
- Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate [NCIt concept]
- Larotrectinib Sulfate [NCIt concept]
- Paltimatrectinib [NCIt concept]
- Pan-TRK Inhibitor ONO-7579 [NCIt concept]
- Repotrectinib [NCIt concept]
- Selitrectinib [NCIt concept]
- Utatrectinib [NCIt concept]
- Zurletrectinib [NCIt concept]
- c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084 [NCIt concept]

Keyword's position in hierarchy(ies) :

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