" /> Immunoglobulin Heavy Locus - CISMeF





Preferred Label : Immunoglobulin Heavy Locus;

NCIt synonyms : Immunoglobulin Heavy Chain Gene; Immunoglobulin Heavy Chain Locus; Immunoglobulin Heavy Gene; IGH;

NCIt definition : This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink);

GenBank Accession Number : NG_001019;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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