Preferred Label : IGH/NSD2 Fusion Gene;
NCIt synonyms : IGH::NSD2 Fusion Gene; IGH-NSD2 Fusion; IGH-MMSET Fusion Gene; IGH-NSD2; IGH/WHSC1 Fusion Gene; IGH-WHSC1 Fusion Gene; IGH-NSD2 Fusion Gene;
NCIt definition : A fusion gene that results from a chromosomal translocation, t(4;14)(p16;q32), which
juxtaposes the enhancer sequences for the mu-constant region from the immunoglobulin
heavy chain (IGH) gene locus upstream of exon 3, 4 or 5 of the NSD2 gene. This rearrangement
is associated with multiple myeloma and monoclonal gammopathy of uncertain significance.;
NCIt note : This fusion results in overexpression of the either full-length or N-terminally truncated
forms of the histone-lysine N-methyltransferase NSD2 protein. Expression of the truncated
protein may be associated with a poorer clinical outcome.;
PubMed : 15677557; 28881672;
Origin ID : C217042;
gene_has_abnormality
- gene_involved_in_molecular_abnormality
- related_to_genetic_biomarker
