Preferred Label : IGH/CRLF2 Fusion Gene;
NCIt synonyms : IGH-CRLF2 Fusion Gene; IGH::CRLF2 Fusion Gene;
NCIt definition : A fusion gene that results from a chromosomal translocation, either t(X;14)(p22;q32)
or t(Y;14)(p11;q32), which fuses the transcriptional enhancers of the IGH gene locus
with regulatory regions of the CRLF2 gene. This rearrangement is associated with acute
lymphoblastic leukemia and expression of this fusion gene results in overexpression
of the cytokine receptor-like factor 2 protein.;
PubMed : 22851563;
Origin ID : C113512;
UMLS CUI : C3829570;
Semantic type(s)
- concept_is_in_subset
- related_to_genetic_biomarker
