" /> CCND1/IGH Fusion Gene - CISMeF





Preferred Label : CCND1/IGH Fusion Gene;

NCIt synonyms : BCL1-IgH Fusion Gene; CCND1-IGH; IgH-BCL1 Fusion Gene; IGH/CCND1 Fusion Gene; CCND1-IGH Fusion Gene; IGH-CCND1 Fusion Gene; CCND1::IGH Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(11;14)(q13;q32) which places the CCND1 gene within a promoter region located in the immunoglobulin heavy chain gene locus (IGH). This rearrangement is associated with numerous lymphoproliferative B-cell malignancies.;

NCIt note : This translocation allows the expression of the CCND1 gene to be controlled by the IgG heavy chain promoter, which causes overexpression of the G1/S-specific cyclin-D1 protein.;

NCI Metathesaurus CUI : CL1792870;

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29/05/2024


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