phenytoin - CISMeF

Preferred Label : phenytoin;

MeSH definition : An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.;

MeSH synonym : fenitoin; 5,5-diphenylhydantoin; diphenylhydantoin; 5,5-diphenylimidazolidine-2,4-dione;

CISMeF synonym : phizer brand of phenytoin; phenytoin phizer brand; pfizer brand of phenytoin; phenytoin pfizer brand; park davis brand of phenytoin;

MeSH hyponym : epanutin; Phenytoin Sodium; hydantol; dihydan; epamin; difenin; antisacer; Sodium Diphenylhydantoinate; Diphenylhydantoinate, Sodium;

Related MeSH term : dilantin;

MeSH CAS label : 2,4-Imidazolidinedione, 5,5-diphenyl-;

MeSH Related Number : 57-41-0 (Phenytoin); 4182431BJH;

Registry Number MeSH : 57-41-0;

Wikipedia link : https://en.wikipedia.org/wiki/Phenytoin;

Codes EINECS : 200-328-6;

Is substance : O;

UNII : 6158TKW0C5;

InChIKey : CXOFVDLJLONNDW-UHFFFAOYSA-N;

Details

Origin ID

D010672;

UMLS CUI

C0031507;

ATC code(s)
- phenytoin [ATC Code]
- phenytoin, combinations [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Dilantin [ICHI extension code]
- Diphenylhydantoin [ICHI extension code]
- Epanutin [ICHI extension code]
- Phenytoin Sodium [NCIt concept]
- phenytoin [EMDN type]
- phenytoin [medical devices type]
CISMeF manual mappings
- phenytoin [Substance BNPC]
Currated CISMeF NLP mapping
- Diphenylhydantoin [ICD-11 Extension code]
- Phenytoin [LOINC component]
- Phenytoin [ICD-11 Extension code]
- Phenytoin [ICHI extension code]
- Phenytoin [SMS substance]
- Phenytoin [NCIt concept]
- Phenytoin (substance) [SNOMED CT concept]
- phenytoin [SNOMED Notion]
Indexing information
- phenytoin receptor [MeSH Supplementary Concept]
Pharmacological action(s)
- Cytochrome P-450 CYP1A2 Inducers [MeSH Descriptor]
- Metabolic Side Effects of Drugs and Substances [MeSH Descriptor]
- Voltage-Gated sodium channel blockers [MeSH Descriptor]
- anticonvulsants [MeSH Descriptor]
Record concept(s)
- Phenhydan [MeSH concept]
- Phenytoin Sodium [MeSH concept]
- antisacer [MeSH concept]
- difenin [MeSH concept]
- dihydan [MeSH concept]
- dilantin [MeSH concept]
- epamin [MeSH concept]
- epanutin [MeSH concept]
- hydantol [MeSH concept]
- phenytoin [MeSH concept]
Related MeSH Supplementary Concept(s)
- 1-acetyl-3-acetoxy-5',5-diphenylhydantoin [MeSH Supplementary Concept]
- 2-cyanoguanidinophenytoin [MeSH Supplementary Concept]
- 3-(2-propylpentanoyl)-5,5-diphenylhydantoin [MeSH Supplementary Concept]
- 3-(hydroxymethyl)phenytoin [MeSH Supplementary Concept]
- 3-(hydroxymethyl)phenytoin N,N-dimethylaminoethyl carbonate [MeSH Supplementary Concept]
- 3-hydroxymethylphenytoin N,N-dimethylglycine ester [MeSH Supplementary Concept]
- 3-pentanoyl-5,5-diphenylhydantoin [MeSH Supplementary Concept]
- 4-aminophenytoin [MeSH Supplementary Concept]
- 5,5-bis(4-hydroxyphenyl)hydantoin [MeSH Supplementary Concept]
- 5,5-diphenyl-2-thiohydantoin-N10 [MeSH Supplementary Concept]
- 5,5-diphenylhydantoin-3-valerate-bovine serum albumin [MeSH Supplementary Concept]
- 5-(2-hydroxyphenyl)-5-phenylhydantoin [MeSH Supplementary Concept]
- 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin [MeSH Supplementary Concept]
- 5-(3,4-dihydroxyphenyl)-5-phenylhydantoin [MeSH Supplementary Concept]
- 5-(3-hydroxyphenyl)-5-phenylhydantoin [MeSH Supplementary Concept]
- 5-(4'-fluorophenyl)-5-phenylhydantoin [MeSH Supplementary Concept]
- 5-(4-hydroxy-3-methoxyphenyl)-5-phenylhydantoin [MeSH Supplementary Concept]
- 5-p-methylphenyl-5-phenylhydantoin [MeSH Supplementary Concept]
- 5-phenyl-5-(4-hydroxyphenyl)hydantoin glucuronide [MeSH Supplementary Concept]
- N'-3-oxymethylglucuronide phenytoin [MeSH Supplementary Concept]
- N,N-dichlorophenytoin [MeSH Supplementary Concept]
- N-acetylphenytoin [MeSH Supplementary Concept]
- N-aminodiphenylhydantoin [MeSH Supplementary Concept]
- PC-796 [MeSH Supplementary Concept]
- diphenylhydantil [MeSH Supplementary Concept]
- diphenylhydantoic acid [MeSH Supplementary Concept]
- diphenylhydantoin-3-phenyltricarbonylchromium ethyl acetate [MeSH Supplementary Concept]
- diphenylthiohydantoin [MeSH Supplementary Concept]
- fosphenytoin [MeSH Supplementary Concept]
- hydanphene [MeSH Supplementary Concept]
- hydroxyphenytoin [MeSH Supplementary Concept]
- mephobarbital, phenobarbital, phenytoin drug combination [MeSH Supplementary Concept]
- phenrytmat [MeSH Supplementary Concept]
- phenytoin dihydrodiol [MeSH Supplementary Concept]
- phenytoin-1-methylnicotininate [MeSH Supplementary Concept]
- phenytoin-bis-hydroxyisobutyrate [MeSH Supplementary Concept]
- ropitoin hydrochloride [MeSH Supplementary Concept]
- sendai cocktail [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Phenytoin Measurement [NCIt concept]
- Phenytoin sodium (product) [Inactive SNOMED CT concept]
- Product containing phenytoin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Diphenylhydantoin [ICD-11 Extension code]
- Phenytoin [ICD-11 Extension code]
- Phenytoin [NCIt concept]
- Phenytoin [LOINC component]
- Phenytoin (substance) [SNOMED CT concept]
- Product containing phenytoin (medicinal product) [SNOMED CT concept]
- phenytoin [ATC Code]
- phenytoin [Substance BNPC]
- phenytoin [SNOMED Notion]
Validated automatic mappings to BTNT
- Dilantin [ICD-11 Extension code]
- Epanutin [ICD-11 Extension code]
- Phenytoin Sodium [NCIt concept]
- Phenytoin sodium [SMS substance]
- Phenytoin sodium (substance) [SNOMED CT concept]
- phenytoin [ATC Code]
- phenytoin sodium [SNOMED Notion]
- phenytoin sodium [Substance BNPC]
- phenytoin sodium [International Nonproprietary Name]

Keyword's position in hierarchy(ies) :

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