valproic acid - CISMeF

Preferred Label : valproic acid;

MeSH definition : A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.; A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.;

MeSH synonym : 2 propylpentanoic acid; 2-propylpentanoic acid; divalproex;

CISMeF synonym : 2-propylvaleric acid; 76584-70-8 (Divalproex sodium); acid, propylisopropylacetic; acid, valproic; propylisopropylacetic acid;

MeSH hyponym : Divalproex Sodium; valproate sodium; depakote; ergenyl; depakene; magnesium valproate; vupral; calcium valproate; valproate; convulsofin; dipropyl acetate; Semisodium Valproate; Sodium Valproate; Valproate Calcium;

MeSH CAS label : pentanoic acid, 2-propyl-;

MeSH Related Number : divalproex sodium; 76584-70-8 (Na salt (2:1)); 99-66-1 (Valproic acid); magnesium valproate; valproate; valproate sodium; calcium valproate; 56CCK4F86G; 5VOM6GYJ0D; 644VL95AO6; Q400352CM2;

Registry Number MeSH : 99-66-1;

Related CAS MeSH : 644VL95AO6 (Divalproex sodium); Q400352CM2 (Magnesium valproate); 614OI1Z5WI (Valproate); 5VOM6GYJ0D (Valproate sodium); 56CCK4F86G (Calcium valproate);

Wikipedia link : https://en.wikipedia.org/wiki/Valproic acid;

Codes EINECS : 202-777-3;

Is substance : O;

UNII : 614OI1Z5WI;

InChIKey : NIJJYAXOARWZEE-UHFFFAOYSA-N;

Details

Origin ID

D014635;

UMLS CUI

C0042291;

ATC code(s)
- valproic acid [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- 2-propylvaleric acid [Substance BNPC]
- Valproic acid (substance) [SNOMED CT concept]
Exact mapping(s) to DCI
- Valproic acid [International Nonproprietary Name]
False automatic mappings
- Other antiepileptic and sedative-hypnotic drugs [ICD-10 Sub-category (who)]
- Poisoning by, adverse effect of and underdosing of other antiepileptic and sedative-hypnotic drugs [ICD-10 Sub-category]
- Valproic acid [ICD-10 Sub-category (who)]
Pharmacological action(s)
- GABA agents [MeSH Descriptor]
- anticonvulsants [MeSH Descriptor]
- antimanic agents [MeSH Descriptor]
- enzyme inhibitors [MeSH Descriptor]
Record concept(s)
- Depakine [MeSH concept]
- Divalproex Sodium [MeSH concept]
- Propylisopropylacetic Acid [MeSH concept]
- Valproic Acid, Sodium Salt (2:1) [MeSH concept]
- calcium valproate [MeSH concept]
- convulsofin [MeSH concept]
- depakene [MeSH concept]
- depakote [MeSH concept]
- dipropyl acetate [MeSH concept]
- ergenyl [MeSH concept]
- magnesium valproate [MeSH concept]
- valproate [MeSH concept]
- valproate sodium [MeSH concept]
- valproic acid [MeSH concept]
- vupral [MeSH concept]
Related MeSH Supplementary Concept(s)
- 1,3-dihexadecanoylamino-2-valproyl-propan-ol [MeSH Supplementary Concept]
- 1,4-butanediol divalproate [MeSH Supplementary Concept]
- 2,4-diene-valproic acid [MeSH Supplementary Concept]
- 2-fluoro-2-propyl-4-pentenoic acid [MeSH Supplementary Concept]
- 2-n-propyl-3-oxopentanoic acid [MeSH Supplementary Concept]
- 3-aminopentanoic acid [MeSH Supplementary Concept]
- 3-aminovalproic acid [MeSH Supplementary Concept]
- 3-hydroxymethylphenytoin valproic acid ester [MeSH Supplementary Concept]
- 3-hydroxypropylpentanoic acid ethyl ester [MeSH Supplementary Concept]
- 3-keto-valproate [MeSH Supplementary Concept]
- 3-ketovalproic acid ethyl ester [MeSH Supplementary Concept]
- 3-oxovalproyl-CoA [MeSH Supplementary Concept]
- 4-aminovalproic acid [MeSH Supplementary Concept]
- 4-hydroxyvalproate [MeSH Supplementary Concept]
- 5-amino-2-(heptan-4-ylamino)-5-oxopentanoic acid [MeSH Supplementary Concept]
- 5-hydroxyvalproate [MeSH Supplementary Concept]
- ACS2 compound [MeSH Supplementary Concept]
- ACS33 compound [MeSH Supplementary Concept]
- DP-VPA [MeSH Supplementary Concept]
- MDC-1112 [MeSH Supplementary Concept]
- N,N'-bis-(2-propylpentanoyl)-1,2-ethanediamine [MeSH Supplementary Concept]
- N,N'-bis-(2-propylpentanoyl)-1,3-propanediamine [MeSH Supplementary Concept]
- N-(2-propylpentanoyl)urea [MeSH Supplementary Concept]
- S-2-pentyl-4-pentynoic hydroxamic acid [MeSH Supplementary Concept]
- delta(3) valproic acid [MeSH Supplementary Concept]
- dimethylenexylitol valproate [MeSH Supplementary Concept]
- dipropylacetamide [MeSH Supplementary Concept]
- encorat [MeSH Supplementary Concept]
- epilim [MeSH Supplementary Concept]
- glucose valproate [MeSH Supplementary Concept]
- glyceryl trivalproate [MeSH Supplementary Concept]
- lysine valproate [MeSH Supplementary Concept]
- pentyl-4-pentynoic acid [MeSH Supplementary Concept]
- pentyl-4-yn-valproic acid [MeSH Supplementary Concept]
- propylisopropylactic acid [MeSH Supplementary Concept]
- sec-butyl-propylacetamide [MeSH Supplementary Concept]
- valproate phenacyl ester [MeSH Supplementary Concept]
- valproic acid antenatal infection [MeSH Supplementary Concept]
- valproic acid ethyl ester [MeSH Supplementary Concept]
- valproic acid glucuronide [MeSH Supplementary Concept]
- valproic acid hydroxamate [MeSH Supplementary Concept]
- valproic acid pivaloyl oxymethyl ester [MeSH Supplementary Concept]
- valpronic acid [MeSH Supplementary Concept]
- valproyl-adenylic acid [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2-propylvaleric acid [Substance BNPC]
- Product containing valproic acid (medicinal product) [SNOMED CT concept]
- Valproic Acid [NCIt concept]
- Valproic acid [International Nonproprietary Name]
- Valproic acid [ICD-11 Extension code]
- Valproic acid (substance) [SNOMED CT concept]
- valproic acid [ATC Code]
- valproic acid [SNOMED Notion]
Validated automatic mappings to BTNT
- valproic acid [ATC Code]
Validated automatic mappings to NTBT
- Valproic acid or valproic acid derivative (substance) [Inactive SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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