Preferred Label : Topiramate;

MeSH definition : A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.;

MeSH synonym : 2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate;

MeSH hyponym : McN-4853; McN4853;

MeSH Related Number : 97240-79-4 (Topiramate);

Wikipedia link : https://en.wikipedia.org/wiki/Topiramate;

UNII : 0H73WJJ391;

Details


Main resources

You can consult :

A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.

https://ansm.sante.fr/actualites/topiramate-epitomax-et-generiques-et-troubles-neurodeveloppementaux-mise-en-place-de-mesures-en-europe-pour-limiter-lutilisation-pendant-la-grossesse
2023
false
false
false
France
French
pharmacovigilance note
guidelines for drug use
Topiramate
pregnancy
europe
Neurodevelopmental Disorders
risk
risk management
drug evaluation
Topiramate
france
anticonvulsants
anticonvulsants
anticonvulsants
Topiramate
topiramate
Female of Childbearing Potential

---
https://ansm.sante.fr/informations-de-securite/medicaments-contenant-du-topiramate-epitomax-et-generiques-modification-des-conditions-de-prescription-et-de-delivrance
https://ansm.sante.fr/actualites/topiramate-et-risques-chez-les-enfants-exposes-pendant-la-grossesse-modification-des-conditions-de-prescription-et-de-delivrance-aux-femmes-concernees-5
2023
false
false
false
France
French
abnormalities, drug-induced
Topiramate
Topiramate
teratogens
pregnancy
drug information
topiramate
risk
risk management
In Utero Drug Exposure
Neurodevelopmental Disorders
child

---
https://ansm.sante.fr/actualites/topiramate-pregabaline-et-valproate-publication-de-nouvelles-donnees-sur-les-risques-lies-a-lexposition-a-ces-medicaments
2022
false
false
false
France
French
pharmacovigilance note
pregnancy
Topiramate
Pregabalin
valproic acid
abnormalities, drug-induced
fertility
anticonvulsants
Neurodevelopmental Disorders
Exposure during pregnancy

---
https://www.has-sante.fr/jcms/p_3382539/fr/sam-de-l-ansm-sur-le-topiramate-modification-des-conditions-de-prescription-et-de-delivrance-cpd-pour-les-patientes-afin-de-limiter-les-risques-lies-a-l-exposition-in-utero
2022
France
algorithms
clinical tool
drug information
has patient
delivery, obstetric
operations research
Exhibition
mosaic variegated aneuploidy syndrome
macrophage activation syndrome
drug, nos
uterus, nos
effects of exposure to external cause, nos
Abstracting and Indexing
medical futility
prescription, nos
indexing
risk
decision support techniques
pharmaceutical preparations
meconium aspiration syndrome
patients
Topiramate

---
https://ansm.sante.fr/actualites/topiramate-risque-de-troubles-neurodeveloppementaux-chez-les-enfants-exposes-in-utero-et-rappel-des-regles-dutilisation-chez-les-femmes
2022
false
false
false
France
French
Neurodevelopmental Disorders
pregnancy
pharmacovigilance note
Topiramate
Exposure during pregnancy
anticonvulsants
topiramate
guidelines for drug use
risk
risk management
child
Autism Spectrum Disorder
intellectual disability

---
https://www.cochrane.org/fr/CD010008/EPILEPSY_topiramate-dans-lepilepsie-myoclonique-juvenile
2021
United Kingdom
review of literature
french abstract
Myoclonus
myoclonic epilepsy, juvenile
Topiramate
Epilepsy
juvenile myoclonic epilepsy
Epilepsy

---
https://www.cochrane.org/fr/CD001417/le-topiramate-en-traitement-dappoint-pour-lepilepsie-focale-resistante-aux-medicaments
false
false
false
France
United Kingdom
meta-analysis
french abstract
anticonvulsants
topiramate
Drug Resistant Epilepsy
epilepsies, partial
fructose
fructose
Topiramate

---
http://www.lecrat.eu/?s=Topiramate+dans+la+migraine+%28grossesse+et+allaitement%29
false
false
false
France
headache
drug information
pregnancy, nos
breast feeding
sick headache
pregnancy
migraine disorders
migraine
Topiramate

---
http://www.lecrat.eu/?s=Topiramate
false
false
France
French
anticonvulsants
pregnancy
neuroprotective agents
fructose
breast feeding
topiramate
drug information
Topiramate

---
https://www.cochrane.org/fr/CD012065/topiramate-contre-carbamazepine-en-monotherapie-dans-lepilepsie
2019
false
false
false
France
United Kingdom
treatment outcome
epilepsies, partial
anticonvulsants
review of literature
french abstract
Topiramate
carbamazepine
epilepsy, tonic-clonic

---
https://pharmacomedicale.org/medicaments/par-specialites/item/topiramate
2017
false
true
false
France
Topiramate
Topiramate
epilepsy
anticonvulsants
anticonvulsants
anticonvulsants
topiramate
drug information
Topiramate

---
https://www.minerva-ebp.be/FR/Article/2125
2017
false
false
false
false
Belgium
French
Dutch
critical appraisal or critical reading
child
adolescent
migraine disorders
amitriptyline
placebos
treatment outcome
amitriptyline
Evidence-Based medicine
headache disorders
Topiramate
Topiramate

---
Topiramate for pediatric migraine prevention
http://www.cfp.ca/content/63/7/532
2017
false
false
false
Canada
French
English
journal article
child
migraine disorders
treatment outcome
randomized controlled trials as topic
comparative effectiveness research
canada
Drugs used in migraine prophylaxis (product)
Migraine prophylaxis
chemoprevention
fructose
fructose
fructose
Topiramate
Topiramate

---
https://www.has-sante.fr/portail/jcms/c_2797158/fr/epitomax
2017
true
France
French
Lennox Gastaut Syndrome
seizures
adolescent
administration, oral
anticonvulsants
topiramate
insurance, health, reimbursement
adult
child
migraine disorders
epilepsies, partial
fructose
evaluation of the transparency committee
Topiramate

---
http://www.cochrane.org/fr/CD003384/utilisation-du-topiramate-pour-traiter-les-episodes-aigus-de-troubles-bipolaires
2016
false
false
false
France
United Kingdom
French
french abstract
bipolar disorder
adult
acute disease
treatment outcome
central nervous system agents
central nervous system agents
review of literature
Topiramate
Topiramate

---
https://www.minerva-ebp.be/fr/article/1064
2015
false
false
false
false
minerva-ebm.be
Belgium
French
Dutch
critical appraisal or critical reading
alcoholism
meta-analysis as topic
adult
harm reduction
naltrexone
drugs used in alcohol dependence
nalmefene
treatment outcome
alcohol drinking
secondary prevention
Topiramate
Acamprosate

---
http://www.sciencedirect.com/science/article/pii/S0755498214003091
doi:10.1016/j.lpm.2014.02.030
2014
false
false
false
France
French
English
journal article
behavior, addictive
alcoholism
treatment outcome
review literature as topic
substance-related disorders
Feeding and Eating Disorders
fructose
fructose
Topiramate

---
http://www.has-sante.fr/portail/display.jsp?id=c_532196
http://www.has-sante.fr/portail/jcms/c_1735612/fr/epitomax
2014
France
French
tablets
administration, oral
anticonvulsants
topiramate
insurance, health, reimbursement
adult
child
migraine disorders
epilepsy, generalized
epilepsies, partial
fructose
capsules
evaluation of the transparency committee
Topiramate

---
http://www.prescrire.org/Fr/3/31/48396/0/NewsDetails.aspx
2013
phentermine
appetite depressants
Topiramate

---
http://www.prescrire.org/Fr/3/31/48791/0/2013/ArchiveNewsDetails.aspx?page=1
2013
false
false
false
french abstract
appetite depressants
phentermine
association
Topiramate

---
http://www.cochrane.org/fr/CD010610/topiramate-pour-la-prevention-des-crises-de-migraine-chez-ladulte
2013
false
United Kingdom
France
French
headache
meta-analysis
migraine disorders
adult
treatment outcome
fructose
french abstract
Topiramate

---
http://www.cochrane.org/fr/CD008314/le-topiramate-pour-traiter-la-douleur-neuropathique-ou-la-fibromyalgie
2013
false
United Kingdom
France
French
french abstract
adult
treatment outcome
neuralgia
fibromyalgia
fructose
review of literature
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65601550
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63707245
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=66201057
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63377114
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67971025
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63727792
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68670605
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61024496
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=66777971
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68002755
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64059449
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65161161
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61584445
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60757296
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68174413
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62072985
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62819469
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60152703
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62373974
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61738808
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63515743
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60303404
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=69722948
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62431146
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63652717
2012
France
summary of product characteristics
package leaflet
capsules
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67549636
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62955768
2012
France
summary of product characteristics
package leaflet
capsules
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62176877
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60649986
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61766832
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65352330
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61587466
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60786337
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=66961409
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68906660
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64137353
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68353836
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65681436
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64738083
2012
France
summary of product characteristics
package leaflet
tablets
Topiramate

---
http://www.lecrat.eu/?s=Topiramate+dans+l%27%C3%A9pilepsie
2009
France
French
epilepsy
anticonvulsants
breast feeding
pregnancy
topiramate
fructose
drug information
Topiramate

---
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/Topiramate.aspx
2009
false
Canada
French
English
fructose
anticonvulsants
anticonvulsants
topiramate
administration, oral
child
drug information
patient education handout
Topiramate
Topiramate

---
https://www.minerva-ebp.be/fr/article/808
2005
false
false
minerva-ebm.be
Belgium
French
headache
antimigraine preparations
migraine disorders
treatment outcome
migraine disorders
anticonvulsants
fructose
critical appraisal or critical reading
Topiramate

---
http://www.fmoq.org/Lists/FMOQDocumentLibrary/fr/Le%20M%C3%A9decin%20du%20Qu%C3%A9bec/Archives/2000%20-%202009/119-120PHDuperron0304.pdf
2004
Canada
French
bipolar disorder
fructose
anticonvulsants
journal article
Topiramate

---
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18/05/2024


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