Preferred Label : naltrexone;

MeSH definition : Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.;

CISMeF synonym : lacer brand of naltrexone hydrochloride; Schering-Plough brand of naltrexone hydrochloride; schering plough brand of naltrexone hydrochloride; lamepro brand of naltrexone hydrochloride; united drug brand of naltrexone hydrochloride; orphan brand of naltrexone hydrochloride; Bristol-Myers squibb brand of naltrexone hydrochloride; bristol myers squibb brand of naltrexone hydrochloride; du pont brand of naltrexone hydrochloride; pharmazam brand of naltrexone hydrochloride; hydrochloride, naltrexone;

MeSH hyponym : trexan; antaxone; ReVia; Naltrexone Hydrochloride; celupan; EN-1639A; EN 1639A; EN1639A; Nemexin; Nalorex;

MeSH CAS label : Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-;

MeSH Related Number : 16590-41-3 (Naltrexone); naltrexone hydrochloride; Z6375YW9SF;

Registry Number MeSH : 16590-41-3;

Related CAS MeSH : Z6375YW9SF (Naltrexone hydrochloride);

Wikipedia link : https://en.wikipedia.org/wiki/Naltrexone;

Codes EINECS : 240-649-9;

Is substance : O;

UNII : 5S6W795CQM;

InChIKey : DQCKKXVULJGBQN-XFWGSAIBSA-N;

Details


Main resources

You can consult :

Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.

https://www.cfp.ca/content/69/9/e179
2023
Canada
journal article
naltrexone
bupropion
naltrexone
Naltrexone
Propranolol Hydrochloride
weight loss
bupropion
bupropion hydrochloride, naltrexone hydrochoride drug combination
Bupropion

---
https://www.has-sante.fr/jcms/p_3259937/fr/selincro
2021
false
false
false
France
French
evaluation of the transparency committee
treatment outcome
insurance, health, reimbursement
nalmefene hydrochloride
administration, oral
adult
alcoholism
alcohol drinking
nalmefene
nalmefene
naltrexone
naltrexone

---
https://www.ema.europa.eu/en/medicines/human/EPAR/rizmoic
2019
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
naldemedine
naldemedine
analgesics, opioid
administration, oral
receptors, opioid, kappa
receptors, opioid, delta
receptors, opioid, mu
product surveillance, postmarketing
adult
aged
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
naldemedine
Opioid-Induced Constipation
naltrexone
naltrexone
naltrexone

---
https://pharmactuel.com/index.php/pharmactuel/article/view/1230
2019
false
false
false
false
Canada
Buprenorphine, Naloxone Drug Combination
comparative effectiveness research
naltrexone
treatment outcome
opioid-related disorders
Delayed-Action preparations
critical appraisal or critical reading

---
https://www.has-sante.fr/portail/jcms/c_2883463/fr/revia
2018
false
true
false
France
naltrexone
administration, oral
alcohol abstinence
alcoholism
treatment outcome
insurance, health, reimbursement
Naltrexone Hydrochloride
evaluation of the transparency committee
ReVia
naltrexone
naltrexone

---
https://www.has-sante.fr/portail/jcms/c_2872648/fr/selincro
2018
false
false
false
false
France
French
evaluation of the transparency committee
nalmefene hydrochloride
nalmefene
nalmefene
naltrexone
naltrexone

---
http://www.has-sante.fr/portail/jcms/c_2749479/fr/relistor
2017
false
false
false
France
French
evaluation of the transparency committee
naltrexone methylbromide
methylnaltrexone bromide
Opioid-Induced Constipation
methylnaltrexone
quaternary ammonium compounds
naltrexone
naltrexone

---
https://www.minerva-ebp.be/FR/Analysis/477
2017
false
false
false
Belgium
French
Dutch
alcoholism
scientific and technical information
treatment outcome
nalmefene
nalmefene
narcotic antagonists
quality of life
meta-analysis as topic
morbidity
alcoholism
naltrexone
naltrexone

---
https://syntheses.univ-rennes1.fr/search-theses/notice/view/rennes1-ori-wf-1-7999?height=500&width=900
2016
false
false
false
France
French
dissertations, academic
nalmefene
baclofen
alcohol-related disorders
nalmefene
naltrexone

---
https://www.minerva-ebp.be/fr/article/1064
2015
false
false
false
false
minerva-ebm.be
Belgium
French
Dutch
critical appraisal or critical reading
alcoholism
meta-analysis as topic
adult
harm reduction
naltrexone
drugs used in alcohol dependence
nalmefene
treatment outcome
alcohol drinking
secondary prevention
Topiramate
Acamprosate

---
https://www.ema.europa.eu/medicines/human/EPAR/Mysimba
2015
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug combinations
drug approval
europe
naltrexone
naltrexone
bupropion
bupropion
anti-obesity agents
anti-obesity agents
product surveillance, postmarketing
adult
overweight
obesity
overweight
body mass index
administration, oral
Delayed-Action preparations
appetite
energy metabolism
aged
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
bupropion hydrochloride, naltrexone hydrochoride drug combination
bupropion hydrochloride, naltrexone hydrochoride drug combination
bupropion and naltrexone
Product containing bupropion and naltrexone in oral dose form (medicinal product form)
drug combinations
drug combinations
naltrexone
bupropion

---
http://www.has-sante.fr/portail/jcms/c_2030380/fr/revia
http://www.has-sante.fr/portail/jcms/c_923060/revia
2015
false
France
French
treatment outcome
alcohol abstinence
Naltrexone Hydrochloride
naltrexone
alcoholism
administration, oral
naltrexone
insurance, health, reimbursement
evaluation of the transparency committee

---
http://www.cochrane.org/fr/CD006749
2014
false
false
false
United Kingdom
France
Drug detoxification (regime/therapy)
treatment outcome
opioid-related disorders
social support
narcotic antagonists
buprenorphine
clonidine
naltrexone
review of literature
french abstract
adolescent
opioid-related disorders

---
http://www.cochrane.org/fr/CD010410/la-naltrexone-a-faible-dose-pour-le-traitement-de-la-maladie-de-crohn-active
false
false
false
France
United Kingdom
review of literature
french abstract
treatment outcome
dose-response relationship, drug
narcotic antagonists
naltrexone
crohn disease

---
http://www.has-sante.fr/portail/jcms/c_1716023/fr/selincro
2014
false
false
false
France
French
English
evaluation of the transparency committee
administration, oral
treatment outcome
insurance, health, reimbursement
nalmefene hydrochloride
nalmefene hydrochloride
nalmefene
nalmefene
nalmefene
narcotic antagonists
narcotic antagonists
alcohol drinking
adult
alcoholism
guidelines for drug use
naltrexone
naltrexone
naltrexone

---
http://www.avisdexperts.ch/videos/view/897/1
2013
false
false
false
Switzerland
French
alcoholism
nalmefene
video recording
naltrexone
naltrexone

---
http://www.lecrat.eu/?s=Naltrexone
2013
France
French
naltrexone
pregnancy
narcotic antagonists
naltrexone
drug information

---
https://www.ema.europa.eu/medicines/human/EPAR/Selincro
2013
false
United Kingdom
French
English
nalmefene
nalmefene
drug approval
treatment outcome
administration, oral
nalmefene hydrochloride
nalmefene hydrochloride
summary of product characteristics
package leaflet
drug evaluation
syndication feed
alcoholism
adult
naltrexone
social support
narcotic antagonists
narcotic antagonists
randomized controlled trials as topic
alcohol drinking
drug evaluation, preclinical
drug interactions
pregnancy
breast feeding
Nalmefene hydrochloride (product)
nalmefene

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60370919
2012
France
summary of product characteristics
package leaflet
tablets
naltrexone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67115586
2012
France
summary of product characteristics
package leaflet
naltrexone
tablets
Naltrexone Hydrochloride

---
http://www.has-sante.fr/portail/jcms/c_399441/nalorex
http://www.has-sante.fr/portail/jcms/c_1231576/nalorex
http://www.has-sante.fr/portail/upload/docs/application/pdf/2012-04/nalorex_29022012_avis_ct11925.pdf
http://www.has-sante.fr/portail/display.jsp?id=c_538419
2012
France
French
secondary prevention
naltrexone
administration, oral
opioid-related disorders
narcotic antagonists
insurance, health, reimbursement
tablets
drugs used in opioid dependence
evaluation of the transparency committee

---
http://www.cochrane.org/fr/CD001333
2011
United Kingdom
France
French
meta-analysis
opioid-related disorders
administration, oral
naltrexone
treatment outcome
narcotic antagonists
french abstract

---
https://www.ema.europa.eu/medicines/human/EPAR/Relistor
2011
false
United Kingdom
French
English
Drug-induced constipation (disorder)
syndication feed
naltrexone
narcotic antagonists
constipation
quaternary ammonium compounds
adult
constipation
analgesics, opioid
narcotic antagonists
naltrexone
naltrexone
quaternary ammonium compounds
drug approval
drug labeling
pregnancy
breast feeding
treatment outcome
injections, subcutaneous
drug interactions
drug evaluation, preclinical
methylnaltrexone
methylnaltrexone
methylnaltrexone bromide
drug evaluation
summary of product characteristics
package leaflet

---
http://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/14087a-fra.php
http://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/14622a-fra.php
2010
Canada
English
French
constipation
methylnaltrexone
naltrexone
methylnaltrexone bromide
narcotic antagonists
quaternary ammonium compounds
injections, subcutaneous
Gastrointestinal perforation
intestinal perforation
pharmacovigilance note

---
http://www.cochrane.org/fr/CD001867
2010
United Kingdom
France
French
meta-analysis
alcohol-related disorders
narcotic antagonists
treatment outcome
naltrexone
french abstract

---
https://www.cadth.ca/sites/default/files/cdr/complete/cdr_complete_Relistor_January-30-2009-fr.pdf
2009
false
Canada
French
Drug-induced constipation (disorder)
narcotic antagonists
quaternary ammonium compounds
naltrexone
receptors, opioid, mu
constipation
constipation
analgesics, opioid
injections, subcutaneous
pharmaceutical solutions
treatment outcome
terminal care
methylnaltrexone
methylnaltrexone bromide
drug evaluation

---
http://www.cochrane.org/fr/CD006140
2008
false
true
false
United Kingdom
France
treatment outcome
review of literature
french abstract
opioid-related disorders
naltrexone

---
http://www.reseau-pic.info/?dest=medicaments/naltrexone.htm&med=REVIA®
2004
France
French
naltrexone
alcoholism
naltrexone
narcotic antagonists
alcoholism
Contraindications, Drug
narcotic antagonists
naltrexone
narcotic antagonists
patient education handout

---
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14/05/2024


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