Preferred Label : Naltrexone;
NCIt synonyms : Naltrexone Base;
NCIt related terms : Vivitrol;
NCIt definition : A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone
reverses the effects of opioid analgesics by binding to the various opioid receptors
in the central nervous system, including the mu-, kappa- and gamma-opioid receptors.
This leads to an inhibition of the typical actions of opioid analgesics, including
analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical
dependence. Naltrexone is longer-acting and more potent compared to naloxone.;
Alternative definition : NCI-GLOSS: A drug that blocks the action of opiates (drugs used to treat pain). It
may be used in the treatment of intravenous opiate addiction or alcohol dependence.
Naltrexone is also being studied in the treatment of breast cancer. It may block the
effects of the hormone estrogen, which causes some breast cancer cells to grow, or
block the blood flow to tumors. It is a type of opiate antagonist.;
UNII : 5S6W795CQM;
InChIKey : DQCKKXVULJGBQN-XFWGSAIBSA-N;
CAS number : 16590-41-3;
Drug name : Vivitrol;
Chemical formula : C20H23NO4;
ChEBI ID : CHEBI:7465;
Codes from synonyms : CDR0000549339; CDR0000528022; 00452;
Origin ID : C62055;
UMLS CUI : C0027360;
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
concept_is_in_subset
has_salt_form
is_free_acid_or_base_form_of
https://www.cfp.ca/content/69/9/e179
2023
Canada
journal article
naltrexone
bupropion
naltrexone
Naltrexone
Propranolol Hydrochloride
weight loss
bupropion
bupropion hydrochloride, naltrexone hydrochoride drug combination
Bupropion
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