Naltrexone - CISMeF

Preferred Label : Naltrexone;

NCIt synonyms : Naltrexone Base;

NCIt related terms : Vivitrol;

NCIt definition : A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the various opioid receptors in the central nervous system, including the mu-, kappa- and gamma-opioid receptors. This leads to an inhibition of the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naltrexone is longer-acting and more potent compared to naloxone.;

Alternative definition : NCI-GLOSS: A drug that blocks the action of opiates (drugs used to treat pain). It may be used in the treatment of intravenous opiate addiction or alcohol dependence. Naltrexone is also being studied in the treatment of breast cancer. It may block the effects of the hormone estrogen, which causes some breast cancer cells to grow, or block the blood flow to tumors. It is a type of opiate antagonist.;

UNII : 5S6W795CQM;

InChIKey : DQCKKXVULJGBQN-XFWGSAIBSA-N;

CAS number : 16590-41-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 16590-41-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Vivitrol;

Chemical formula : C20H23NO4;

ChEBI ID : CHEBI:7465;

Codes from synonyms : CDR0000549339; CDR0000528022; 00452;

Details

Origin ID

C62055;

UMLS CUI

C0027360;

Automatic exact mappings (from CISMeF team)
- Naltrexone [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Naltrexone [ICD-11 Extension code]
- Naltrexone [LOINC component]
- Naltrexone (substance) [SNOMED CT concept]
- Product containing naltrexone (medicinal product) [SNOMED CT concept]
- naltrexone [ATC Code]
- naltrexone [Substance BNPC]
- naltrexone [MeSH concept]
- naltrexone [MeSH Descriptor]
- naltrexone [SNOMED Notion]
Validated automatic mappings to BTNT
- naltrexone [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Naltrexone Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Naltrexone Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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