Preferred Label : Naltrexone Hydrochloride;
NCIt synonyms : (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride; Naltrexone;
NCIt related terms : Naltrexone.HCl; ReVia;
NCIt definition : The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive
opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse
the effects of opioids by binding to various opioid receptors in the central nervous
system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects
of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and
physical dependence are inhibited. Naltrexone is longer-acting and more potent compared
to naloxone.;
Alternative definition : NCI-GLOSS: A drug that blocks the action of opiates (drugs used to treat pain). It
may be used in the treatment of intravenous opiate addiction or alcohol dependence.
Naltrexone hydrochloride is also being studied in the treatment of breast cancer.
It may block the effects of the hormone estrogen, which causes some breast cancer
cells to grow, or block the blood flow to tumors. It is a type of opiate antagonist.;
UNII : Z6375YW9SF;
InChIKey : RHBRMCOKKKZVRY-ITLPAZOVSA-N;
CAS number : 16676-29-2;
Drug name : Depade; Revia;
Chemical formula : C20H23NO4.HCl;
Codes from synonyms : CDR0000549316; CDR0000549273; 20102;
Origin ID : C679;
UMLS CUI : C0355800;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
