MeSH annotation : caused by dis or inj; coord IM with specific intestine (IM) or specific precoord intestinal
dis (IM); intestinal rupture does not go here: index with INTESTINES /inj or specific
intestine /inj (IM) RUPTURE (NIM) or specific intestine (IM) or specific precoord
intestinal dis (IM) RUPTURE, SPONTANEOUS (NIM);
Wikipedia link : https://en.wikipedia.org/wiki/Acute abdomen;
Opening or penetration through the wall of the INTESTINES.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006182.pub3/full/fr 2025 false true false France United Kingdom infant, newborn treatment outcome Spontaneous Perforation review of literature french abstract intestinal perforation enterocolitis, necrotizing infant, premature drainage laparotomy infant, low birth weight
--- The risk of colitis and gastrointestinal perforation has been added to the Warnings
and Precautions and Adverse Reactions sections of the Canadian product monograph for
Mekinist (trametinib) https://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2017-01-page4-fra.php#pmu 2017 false false false Canada French English pharmacovigilance note administration, oral journal article trametinib risk factors trametinib Digestive System Perforation intestinal perforation colitis socioeconomic factors pyridones pyrimidinones