The risk of colitis and gastrointestinal perforation has been added to the Warnings
and Precautions and Adverse Reactions sections of the Canadian product monograph for
Mekinist (trametinib) https://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2017-01-page4-fra.php#pmu 2017 false false false Canada French English pharmacovigilance note administration, oral journal article trametinib risk factors trametinib Digestive System Perforation intestinal perforation colitis socioeconomic factors pyridones pyrimidinones