Phenytoin Sodium

Preferred Label : Phenytoin Sodium;

NCIt synonyms : 5,5-Diphenyl-2,4-imidazolidinedione, Monosodium Salt;

NCIt related terms : Dilantin;

NCIt definition : The sodium salt form of phenytoin, a hydantoin derivate and non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin sodium promotes sodium efflux from neurons located in the motor cortex, thereby stabilizing the neuron and inhibiting synaptic transmission. This leads to a reduction in posttetanic potentiation at synapses, an inhibition of repetitive firing of action potentials and ultimately inhibits the spread of seizure activity.;

Alternative definition : NCI-GLOSS: A drug used to treat or prevent seizures or convulsions that may be caused by epilepsy, brain surgery, or treatment for brain cancer. It is a type of anticonvulsant agent.;

UNII : 4182431BJH;

InChIKey : FJPYVLNWWICYDW-UHFFFAOYSA-M;

CAS number : 630-93-3;

Drug name : Dilantin;

Chemical formula : C15H11N2O2.Na;

NSC code : 8722;

Codes from synonyms : CDR0000658858; CDR0000658859; NSC0008722;

Details

Origin ID

C48011;

UMLS CUI

C0237417;

Automatic exact mappings (from CISMeF team)
- Phenytoin [LOINC component]
- phenytoin [MeSH Descriptor]
Currated CISMeF NLP mapping
- Phenytoin Sodium [MeSH concept]
- Phenytoin sodium [SMS substance]
- Phenytoin sodium (substance) [SNOMED CT concept]
- phenytoin sodium [Substance BNPC]
- phenytoin sodium [International Nonproprietary Name]
- phenytoin sodium [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Phenytoin Sodium [MeSH concept]
- Phenytoin sodium (product) [Inactive SNOMED CT concept]
- Phenytoin sodium (substance) [SNOMED CT concept]
- phenytoin sodium [International Nonproprietary Name]
- phenytoin sodium [Substance BNPC]
- phenytoin sodium [SNOMED Notion]
Validated automatic mappings to NTBT
- phenytoin [MeSH Descriptor]
- phenytoin [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
has_free_acid_or_base_form
- Phenytoin [NCIt concept]
is_salt_form_of
- Phenytoin [NCIt concept]

Keyword's position in hierarchy(ies) :

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