Phenytoin - CISMeF

Preferred Label : Phenytoin;

NCIt synonyms : Diphenylhydantoin; 5,5-Diphenyl-2,4-imidazolidinedione;

NCIt definition : A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.;

UNII : 6158TKW0C5;

InChIKey : CXOFVDLJLONNDW-UHFFFAOYSA-N;

CAS number : 57-41-0;

Chemical formula : C15H12N2O2;

ChEBI ID : CHEBI:8107;

Codes from synonyms : 00436; 401;

Details

Origin ID

C741;

UMLS CUI

C0031507;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Diphenylhydantoin [ICD-11 Extension code]
- Phenytoin [ICD-11 Extension code]
- Phenytoin [LOINC component]
- Phenytoin (substance) [SNOMED CT concept]
- Product containing phenytoin (medicinal product) [SNOMED CT concept]
- phenytoin [ATC Code]
- phenytoin [Substance BNPC]
- phenytoin [MeSH concept]
- phenytoin [MeSH Descriptor]
- phenytoin [SNOMED Notion]
Validated automatic mappings to BTNT
- phenytoin [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2C19 [NCIt concept]
- Cytochrome P450 2C9 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Phenytoin Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Phenytoin Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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