" /> Aminoacyl-tRNA Ligase Family - CISMeF





Preferred Label : Aminoacyl-tRNA Ligase Family;

NCIt synonyms : Aminoacyl-tRNA Synthetase; Aminoacyl-tRNA Ligase;

NCIt related terms : tRNA-Ligase; ARS;

NCIt definition : A family of ligases that are involved in translation. These enzymes catalyze the transesterification reaction that attaches amino acids with their cognate tRNAs. There are cytoplasmic and mitochondrial forms for many of these enzymes. Some of the cytoplasmic amino acid synthetases are targets for autoantibodies in the autoimmune diseases polymyositis and dermatomyositis.;

Alternative definition : CDISC: One or more of the antigen(s) from the aminoacyl-tRNA synthetase family and are enzymes that attach the appropriate amino acids onto their corresponding tRNAs. This family of proteins may be comprised of (but not limited to) histidyl- (Jo-1), threonyl- (PL-7), alanyl- (PL-12), glycyl- (EJ), isoleucyl- (OJ), asparaginyl- (KS), phenylalanyl- (Zo), and tyrosyl- (YRS) tRNA synthetases. They can be considered as autoantigens and are commonly associated with the autoimmune diseases polymyositis and dermatomyositis.;

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14/05/2024


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