Preferred Label : Tyrosine-tRNA Ligase, Cytoplasmic;
NCIt synonyms : EC 6.1.1.1; Tyrosine tRNA Ligase 1, Cytoplasmic; YARS; Tyrosyl-tRNA Ligase; Tyrosine--tRNA Ligase, Cytoplasmic; TyrRS; Tyrosyl-tRNA Synthetase; Tyrosyl-tRNA Synthetase 1; YARS1; Tyrosyl--tRNA Ligase; Tyrosine-Transfer RNA Ligase; Tyrosyl-tRNA Synthetase, Cytoplasmic;
NCIt definition : Tyrosine-tRNA ligase, cytoplasmic (528 aa, 59 kDa) is encoded by the human YARS1
gene. This protein is involved in the attachment of tyrosine to its cognate tRNA.;
NCIt note : Likely to be among the first proteins to appear in evolution, amino acyl-tRNA synthetases
catalyze tRNA amino acylation by their cognate amino acid. Under apoptotic conditions,
tyrosyl-tRNA synthetase may be secreted and cleaved into an N-terminal IL8-like cytokine
fragment that harbors the catalytic site and a C-terminal EMAP II-like cytokine fragment.
(OMIM, Swiss-Prot, LocusLink);
Origin ID : C21436;
UMLS CUI : C5441736;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
