Isoleucine-tRNA Ligase, Cytoplasmic

Preferred Label : Isoleucine-tRNA Ligase, Cytoplasmic;

NCIt synonyms : Isoleucine--tRNA Ligase, Cytoplasmic; Isoleucine tRNA Ligase 1, Cytoplasmic; IARS1; Isoleucyl-tRNA Synthetase 1; EC 6.1.1.5; IRS;

NCIt related terms : IleRS; Isoleucyl-tRNA Synthetase; OJ ANTIGEN;

NCIt definition : Isoleucine-tRNA ligase, cytoplasmic (1262 aa, 144 kDa) is encoded by the human IARS1 gene. This protein is involved in in the ligation of isoleucine residues to transfer RNA(Ile).;

Alternative definition : CDISC: An antigen encoded by the IARS1 gene that regulates isoleucyl-transfer RNA synthesis (attaches isoleucine to tRNA). It can be considered as an autoantigen and is commonly associated with the autoimmune diseases anti-synthetase syndrome, polymyositis and dermatomyositis.;

NCIt note : Isoleucine-tRNA ligase, cytoplasmic is a target for autoantibodies in the autoimmune diseases polymyositis and dermatomyositis.;

Details

Origin ID

C200630;

OMIM relation
- Isoleucyl-trna synthetase 1 [OMIM gene]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- IARS1 Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_chemical_classification
- Aminoacyl-tRNA Ligase Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Aminoacyl-tRNA Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- RNA Processing [NCIt concept]
- Translational Regulation [NCIt concept]

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