Histidine-tRNA Ligase, Cytoplasmic

Preferred Label : Histidine-tRNA Ligase, Cytoplasmic;

NCIt synonyms : Histidine Translase; HisRS; EC 6.1.1.21; HARS1; Histidyl-tRNA Synthetase; Histidine--tRNA Ligase, Cytoplasmic; Histidine-tRNA Synthetase, Cytoplasmic;

NCIt related terms : JO-1 ANTIGEN; Histidyl-tRNA Synthetase 1; Histidine tRNA Ligase 1, Cytoplasmic;

NCIt definition : Histidine-tRNA ligase, cytoplasmic (509 aa, 57 kDa) is encoded by the human HARS1 gene. This protein plays a role in the ATP-dependent ligation of histidine to the 3'-end of tRNA.;

Alternative definition : CDISC: An antigen encoded by the HARS1 gene that regulates histidyl-transfer RNA synthesis (attaches histidine to tRNA). It can be considered as an autoantigen and is commonly associated with the autoimmune diseases anti-synthetase syndrome, polymyositis and dermatomyositis.;

NCI Metathesaurus CUI : CL1771890;

Details

Origin ID

C183518;

UMLS CUI

C5575461;

Automatic exact mappings (from CISMeF team)
- Histidine-tRNA ligase [MeSH Descriptor]
- Histidine-transfer ribonucleic acid ligase (substance) [SNOMED CT concept]
- Histidyl-trna synthetase 1 [OMIM gene]
- N(tau)-ribosylhistidine [MeSH Supplementary Concept]
- histidyl-tRNA synthetase 1 [ORDO Gene]
- histidyl-tRNA synthetase 1 [HGNC gene]
OMIM relation
- Histidyl-trna synthetase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HARS1 Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_chemical_classification
- Aminoacyl-tRNA Ligase Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Aminoacyl-tRNA Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- RNA Processing [NCIt concept]
- Translational Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients