Alanine-tRNA Ligase, Cytoplasmic

Preferred Label : Alanine-tRNA Ligase, Cytoplasmic;

NCIt synonyms : AARS1; Alanyl-tRNA Synthetase; Renal Carcinoma Antigen NY-REN-42; AlaRS; Alanyl-tRNA Synthetase, Cytoplasmic; EC 6.1.1.7; Alanine tRNA Ligase 1, Cytoplasmic; Alanine--tRNA Ligase, Cytoplasmic; Alanyl-tRNA Synthetase 1;

NCIt related terms : AARS; PL-12 ANTIGEN;

NCIt definition : Alanine-tRNA ligase, cytoplasmic (968 aa, 107 kDa) is encoded by the human AARS1 gene. This protein plays a role in the ligation of alanine residues to transfer RNA(Ala).;

Alternative definition : CDISC: An antigen encoded by the AARS1 gene that regulates alanyl-transfer RNA synthesis (attaches alanine to tRNA). It can be considered as an autoantigen and is commonly associated with the autoimmune diseases anti-synthetase syndrome, polymyositis and dermatomyositis.;

NCIt note : Alanine-tRNA ligase, cytoplasmic is a target for autoantibodies in the autoimmune diseases polymyositis and dermatomyositis.;

Details

Origin ID

C200633;

OMIM relation
- Alanyl-trna synthetase 1 [OMIM gene]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- AARS1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_chemical_classification
- Aminoacyl-tRNA Ligase Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Aminoacyl-tRNA Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- RNA Processing [NCIt concept]
- Translational Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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