Lysine-tRNA Ligase

Preferred Label : Lysine-tRNA Ligase;

NCIt synonyms : Lysine tRNA Ligase; Lysyl-tRNA Synthetase 1; KARS1; Lysine--tRNA Ligase; EC 6.1.1.6; Lysyl-tRNA Synthetase; LysRS;

NCIt definition : Lysine-tRNA ligase (597 aa, 68 kDa) is encoded by the human KARS1 gene. This protein is involved in in the ligation of lysine residues to transfer RNA(Lys).;

NCIt note : Lysine-tRNA ligase is a target for autoantibodies in the autoimmune diseases polymyositis and dermatomyositis.;

NCI Metathesaurus CUI : CL1915339;

Details

Origin ID

C200659;

UMLS CUI

C5848970;

OMIM relation
- Lysyl-trna synthetase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- KARS1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- KARS1 Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_chemical_classification
- Aminoacyl-tRNA Ligase Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Aminoacyl-tRNA Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- RNA Processing [NCIt concept]
- Translational Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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