Glycine-tRNA Ligase

Preferred Label : Glycine-tRNA Ligase;

NCIt synonyms : Glycyl-tRNA Synthetase; EC 6.1.1.14; GARS; AP-4-A Synthetase; Glycine--tRNA Ligase; Diadenosine Tetraphosphate Synthetase; Glycine tRNA Ligase; GARS1; Ap4A Synthetase; Glycyl-tRNA Synthetase 1;

NCIt related terms : EJ ANTIGEN; GlyRS;

NCIt definition : Glycine-tRNA ligase (739 aa, 83 kDa) is encoded by the human GARS1 gene. This protein plays a role in tRNA aminoacylation.;

Alternative definition : CDISC: An antigen encoded by the GARS1 gene that regulates glycyl-transfer RNA synthesis (attaches glycine to tRNA). It can be considered as an autoantigen and is commonly associated with the autoimmune diseases anti-synthetase syndrome, polymyositis and dermatomyositis.;

NCIt note : Glycyl-tRNA synthetase is a target for autoantibodies in the autoimmune diseases, polymyositis and dermatomyositis.;

NCI Metathesaurus CUI : CL521332;

Details

Origin ID

C132129;

UMLS CUI

C4320088;

Automatic exact mappings (from CISMeF team)
- Glycine-tRNA ligase [MeSH Descriptor]
- Glycine-tRNA ligase [MeSH concept]
- Glycine-transfer ribonucleic acid ligase (substance) [SNOMED CT concept]
- Glycyl-trna synthetase 1 [OMIM gene]
- Phosphoribosylglycinamide formyltransferase/phosphoribosylglycinamide synthetase/phosphoribosylaminoimidazole synthetase [OMIM gene]
- glycine-trna ligase [SNOMED Notion]
- glycyl-tRNA synthetase 1 [ORDO Gene]
- glycyl-tRNA synthetase 1 [HGNC gene]
- ranidae [MeSH Descriptor]
OMIM relation
- Glycyl-trna synthetase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- GARS1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GARS1 Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_chemical_classification
- Aminoacyl-tRNA Ligase Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Aminoacyl-tRNA Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- RNA Processing [NCIt concept]
- Translational Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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