Preferred Label : Autologous PD-1 Antibody-expressing Mesothelin-specific CAR-T Cells;
NCIt synonyms : Autologous PD-1 Antibody-expressing Mesothelin-specific CAR T-cells; Autologous PD-1 Antibody expressing Mesothelin Specific CAR-T Cells;
NCIt definition : Genetically modified, autologous T-lymphocytes that express an antibody that targets
the negative immunoregulatory human cell surface receptor programmed cell death protein
1 (PD-1; PDCD1; CD279) and are transduced with a gene encoding a chimeric antigen
receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin, with
potential immunomodulating and antineoplastic activities. After isolation, transduction,
expansion in culture, and reintroduction into the patient, the autologous PD-1 antibody
expressing mesothelin specific CAR-T cells specifically target and kill mesothelin-expressing
tumor cells. The anti-PD-1 expressed on the CAR-T cells binds to PD-1 expressed on
T-cells and prevents the interaction of PD-1 with its ligand programmed cell death
1 ligand 1 (PD-L1, PD-1L1; CD274) expressed on cancer cells, which prevents PD-1-mediated
signaling and T-cell exhaustion, enhances T-cell activation, and results in enhanced
toxicity in mesothelin-expressing tumor cells. PD-1, an immunoglobulin (Ig) superfamily
transmembrane protein and inhibitory receptor, negatively regulates T-cell activation
and overexpression within the tumor microenvironment and inhibits T-cell function.
Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed
in a variety of cancer cell types.;
NCI Metathesaurus CUI : CL550815;
Origin ID : C148133;
UMLS CUI : C4724836;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
