TCR Activation Pathway

Preferred Label : TCR Activation Pathway;

NCIt related terms : Lck and Fyn tyrosine kinases in initiation of TCR Activation;

Alternative definition : BIOCARTA: T cell activation is initiated by recognition of antigen by the T cell receptor (TCR) in the context of Class II MHC on an antigen-presenting cell. The T cell receptor contains multiple subunits and interacts with several factors to transduce antigen-stimulated T cell activation. One of the key steps that initiates receptor activation is the tyrosine phosphorylation of TCR subunits by the src family protein kinases Lck and Fyn. T cell receptor phosphorylated by Lck and Fyn recruits the ZAP-70 protein kinase to the receptor complex, which becomes activated and stimulates downstream pathways like the Map kinase cascade. The CD45 protein tyrosine phosphatase activates Lck and Fyn by dephosphorylating these proteins and is required for TCR activation. Association of the CD4 coreceptor with Lck may also be involved in Lck activation. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_tcraPathway;

Details

Origin ID

C39245;

UMLS CUI

C1515145;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase C [NCIt concept]
- STE20-Like Serine/Threonine-Protein Kinase [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Delta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Epsilon Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Gamma Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Zeta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD4 [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Tyrosine-Protein Kinase Lck [NCIt concept]
- Tyrosine-Protein Kinase ZAP-70 [NCIt concept]
pathway_has_gene_element
- CD247 wt Allele [NCIt concept]
- CD3D wt Allele [NCIt concept]
- CD3E wt Allele [NCIt concept]
- CD3G wt Allele [NCIt concept]
- CD4 wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- LCK wt Allele [NCIt concept]
- PTPRC wt Allele [NCIt concept]
- SLK wt Allele [NCIt concept]
- ZAP70 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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