Preferred Label : Vascular Endothelial Growth Factor A;
NCIt synonyms : Vascular Permeability Factor; VEGF148; VEGF145; Vascular Endothelial Growth Factor; VEGF189; VEGF121; VEGF-A; VEGF165; VEGF206; VPF; VEGF183;
NCIt related terms : VEGF;
NCIt definition : Vascular endothelial growth factor A (232 aa, 27 kDa) is encoded by the human VEGFA
gene. This protein plays a role in both cell proliferation and angiogenesis.;
Alternative definition : NCI-GLOSS: A substance made by cells that stimulates new blood vessel formation.;
NCIt note : The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206
and VEGF-145 are uncommon. (UniProt); Vascular endothelial growth factor A has multiple protein isoforms that range from
15 kDa to 27 kDa and are the result of alternative splicing. The isoforms are denoted
by the term VEGF followed by the number of amino acids contained therein. This entry
uses VEGF206 to represent the canonical vascular endothelial growth factor A.; Encoded by human VEGF Gene (PDGF/VEGF Family), widely expressed 232-amino acid 27
kD (precursor) VEGF exhibits seven isoforms: VEGF206, -189, -183, -165/VEGF, -148,
-145, and -121. VEGF121 is acidic; VEGF165 is more basic and binds heparin/ECM; VEGF189
is very basic. VEGF is a disulfide-linked, 41-45 kD secreted homodimeric glycoprotein
angiogenic growth factor; it may heterodimerize with PLGF. VEGF inhibits apoptosis
and promotes endothelial proliferation, cell migration, and vascular permeabilization.
VEGF interacts with VEGFR1/FLT-1 and VEGFR2/KDR/FLK1 receptors. VEGF145 may inhibit
-165 binding to FLK1. Collapsin/semaphorin receptor Neuropilin-1 (VEGF165R) mediates
neuronal cell guidance and binds VEGF165 and -145, but not -121; it enhances VEGF165/KDR
binding and chemotaxis. (OMIM, Swiss-Prot, LocusLink, and NCI);
Codes from synonyms : CDR0000044474;
Origin ID : C20450;
UMLS CUI : C1171892;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_affected_by_chemical_or_drug
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_biomarker_type
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
