Anti-KSP/Anti-VEGF siRNAs ALN-VSP02

Preferred Label : Anti-KSP/Anti-VEGF siRNAs ALN-VSP02;

NCIt synonyms : Anti-KSP Anti-VEGF siRNAs ALN-VSP02;

NCIt definition : A lipid nanoparticle formulation containing two small interfering RNAs (siRNAs) for kinesin spindle protein (KSP) and vascular endothelial growth factor (VEGF) with potential antitumor activity. Upon intravenous administration, the siRNAs in KSP/VEGF siRNAs ALN-VSP02ALN bind to both KSP and VEGF messenger RNAs (mRNAs), preventing translation of KSP and VEGF proteins; this may result in growth inhibition of tumor cells that overexpress KSP and VEGF. VEGF and KSP are upregulated in many tumor cells and play an important role in tumor proliferation and survival.;

Molecule name : ALN-VSP02;

NCI Metathesaurus CUI : CL408662;

Details

Origin ID

C82391;

UMLS CUI

C2826144;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Kinesin-Like Protein KIF11 [NCIt concept]
- Vascular Endothelial Growth Factor A [NCIt concept]
- Vascular Endothelial Growth Factor Family [NCIt concept]

Keyword's position in hierarchy(ies) :

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