Kinesin-Like Protein KIF11

Preferred Label : Kinesin-Like Protein KIF11;

NCIt synonyms : Xenopus Homolog of Eg5; Human Kinesin Spindle Protein; Human Eg5 Protein; HsEg5 Protein; Kinesin-Like Protein 1; Thyroid Receptor Interacting Protein 5; Kinesin-Like Spindle Protein HKSP; Kinesin Heavy Chain; TRIP-5; Kinesin Family Member 11; Thyroid Receptor-Interacting Protein 5; Kinesin-Related Motor Protein Eg5; Kinesin-Like 1 Protein; KNSL1 Protein;

NCIt definition : Kinesin-like protein KIF11 (1056 aa, 119 kDa) is encoded by the human KIF11 gene. This protein plays a role in the formation of a bipolar spindle during mitosis.;

NCIt note : Inhibition of KIF11 activity leads to mitotic arrest.;

Details

Origin ID

C48872;

UMLS CUI

C1173400;

Currated CISMeF NLP mapping
- kinesin-like protein 1 [MeSH concept]
- kinesin-like protein 1 [MeSH Supplementary Concept]
OMIM relation
- Kinesin family member 11 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- KIF11 protein, human [MeSH concept]
- KIF11 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- KIF11 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Filanesib [NCIt concept]
- Ispinesib [NCIt concept]
- KSP Inhibitor AZD4877 [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- ATPase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Mitotic Spindle Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Chromosome Segregation [NCIt concept]
- Mitosis [NCIt concept]
is_target
- Anti-KSP/Anti-VEGF siRNAs ALN-VSP02 [NCIt concept]
- Filanesib [NCIt concept]
- Ispinesib [NCIt concept]
- KSP Inhibitor AZD4877 [NCIt concept]
- KSP Inhibitor SB-743921 [NCIt concept]
- Litronesib [NCIt concept]

Keyword's position in hierarchy(ies) :

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