Preferred Label : Fc-VEGFR1 Fusion Protein PB101;
NCIt synonyms : VEGF/PlGF-targeting Decoy Protein PB101; Anti-VEGF-A/PlGF Fc-fusion Protein PB101; VEGF/PGF-targeting Decoy Protein PB101; VEGF Decoy Receptor Fusion Protein PB101;
NCIt definition : A glycosylated decoy receptor fusion protein that is composed of the vascular endothelial
growth factor receptor-1 (VEGFR1; VEGFR-1) backbone and fused to fragments of Fc region,
with potential anti-angiogenic, immunomodulating and antineoplastic activities. Upon
administration, Fc-VEGFR1 fusion protein PB101 targets, binds to and neutralizes placental
growth factor (PlGF; PGF) and VEGF-A and VEGF-B, thereby inhibiting the binding of
PlGF and VEGF-A and -B to VEGFR-1 and prevents subsequent VEGFR-1 phosphorylation
and VEGFR1-mediated signaling. This may result in the inhibition of tumor angiogenesis
and, by blocking blood flow, inhibits tumor cell proliferation. By simultaneously
inhibiting both VEGF and PlGF signaling within the tumor microenvironment (TME), PB101
modulates the immunosuppressive TME and enhances CD8-positive T-cell infiltration
into the tumor. Both PGF, a member of the VEGF sub-family, and VEGF play key roles
in angiogenesis, and are upregulated in many cancers. Tumor vasculature plays an important
role in promoting tumor progression and immune evasion.;
Molecule name : PB-101; PB 101;
Origin ID : C202240;
concept_is_in_subset
- has_target
