Conbercept - CISMeF

Preferred Label : Conbercept;

NCIt definition : A recombinant, soluble, vascular endothelial growth factor receptor (VEGFR) protein composed of the second immunoglobulin (Ig) domain of VEGFR-1, the third and fourth Ig domains of VEGFR-2, and the constant region (Fc) of human immunoglobulin G1 (IgG1) with potential anti-angiogenic activities. Upon intravitreal injection, conbercept, functioning as a soluble decoy receptor, binds with high affinity to all VEGF-A isoforms, VEGF-B, as well as placenta growth factor (PlGF)-1 and PlGF-2. This prevents the binding of these growth factors to their endogenous receptors, potentially inhibiting angiogenesis and tumor cell growth.;

UNII : 1P05PW62F3;

CAS number : 1227158-72-6;

Molecule name : KH 902; KH-902; FP 3; FP-3; KH-903; KH 903;

NCI Metathesaurus CUI : CL973317;

Details

Origin ID

C162879;

UMLS CUI

C5201155;

CISMeF manual mappings
- KH902 fusion protein [MeSH concept]
Currated CISMeF NLP mapping
- KH902 fusion protein [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Placenta Growth Factor [NCIt concept]
- Placenta Growth Factor Isoform 1 [NCIt concept]
- Vascular Endothelial Growth Factor A [NCIt concept]
- Vascular Endothelial Growth Factor A 165 Isoform [NCIt concept]
- Vascular Endothelial Growth Factor B [NCIt concept]

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