Preferred Label : Thalidomide;
NCIt synonyms : N-Phthaloylglutamimide; 3-Phthalimidoglutarimide; 2,6-Dioxo-3-phthalimidopiperidine; Alpha-Phthalimidoglutarimide; 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;
NCIt related terms : Talimol; Kevadon; .alpha.-Phthalimidoglutarimide; 2, 6-Dioxo-3-phthalimidopiperidine; Distaval; Contergan; Pantosediv; N-(2,6-Dioxo-3-piperidyl)phthalimide; Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, ( )-; ( )-Thalidomide; Softenon; (-)-Thalidomide; N-Phthalylglutamic acid imide; Thalomid; Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)-;
NCIt definition : A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic,
immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts
primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha)
in stimulated peripheral monocytes and the activities of interleukins and interferons.
This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In
addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial
growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting
angiogenesis.;
Alternative definition : NCI-GLOSS: A drug that is used to treat multiple myeloma in patients who have just
been diagnosed, and a painful skin disease related to leprosy. It is also being studied
in the treatment of other types of cancer. Thalomid belongs to the family of drugs
called angiogenesis inhibitors.;
UNII : 4Z8R6ORS6L;
InChIKey : UEJJHQNACJXSKW-UHFFFAOYSA-N;
CAS number : 50-35-1;
Drug name : Talimol; Distaval; Softenon; Pantosediv; Kevadon; Sedoval K-17; Thalomid; Synovir; Neurosedyn; Contergan; Sedalis;
Chemical formula : C13H10N2O4;
NSC code : 66847;
ChEBI ID : CHEBI:9513;
Codes from synonyms : CDR0000045458; NSC0091730; CDR0000507648; NSC0066847; NSC0091729; 01269; 488;
Origin ID : C870;
UMLS CUI : C0039736;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
https://pgtmsite.files.wordpress.com/2024/01/thalidomide_es_20081030.pdf
2008
Canada
drug information
thalidomide
Thalidomide
thalidomide
---
