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2024


Abstract: Background
Current literature highlights the difficulty in identifying which pelvic floor muscle (PFM) functions are correlated with urinary incontinence (UI).
Aim
In this study, we compared parameters of PFM function (strength, endurance, tone, control, reaction, and/or coordination) according to continence status in women (presence or absence, type and/or severity of urinary incontinence).
Evidence acquisition
A systematic review was conducted following the 2020 PRISMA guidelines. Three databases (Pubmed, Web of Science, and LiSSa) were searched from inception to December 31, 2021. Assessment of risk of bias was performed using the Joanna Briggs Institute critical appraisal checklist.
Evidence synthesis
The initial research yielded 4733 studies. Forty-two studies met the inclusion criteria, including 4015 participants. No statistical association was found between PFM function and the presence or absence of UI, the different type of UI or the different levels of severity of UI. The heterogeneity in methodologies and analyzes of the results only with the P-value are important limitations of this review.
Conclusion
It appears that muscle function is not always associated with presence or absence of UI. No association is found between PFM function and type or severity of UI. These results reinforce the need to carry out a bio-psycho-social evaluation of UI that does not only focus on PFM functions. As such, the results reported herein can be considered a resource for more specific research.
Résumé
Contexte
La littérature actuelle souligne la difficulté d’identifier quelles fonctions des muscles du plancher pelvien (MPP) sont corrélées à l’incontinence urinaire (IU).
Objectif
Dans cette étude, nous avons comparé les paramètres de la fonction des muscles du plancher pelvien (force, endurance, tonus, contrôle, réaction et/ou coordination) en fonction du statut de continence des femmes (présence ou absence, type et/ou sévérité de l’incontinence urinaire).
Méthode
Une étude systématique a été réalisée conformément aux lignes directrices PRISMA 2020. Trois bases de données (Pubmed, Web of Science, et LiSSa) ont été consultées depuis le début jusqu’au 31 décembre 2021. L’évaluation du risque de biais a été réalisée à l’aide de la Joanna Briggs Institute critical appraisal checklist.
Résultats
La recherche initiale a donné lieu à 4733 études. Quarante-deux études répondaient aux critères d’inclusion, incluant 4015 participants. Aucune association statistique n’a été trouvée entre la fonction des MPP et la présence ou l’absence d’IU, les différents types d’IU ou les différents niveaux de sévérité de l’IU. L’hétérogénéité des méthodologies et l’analyse des résultats uniquement à l’aide de la valeur p sont des limites importantes de cette étude.
Conclusion
Il semble que la fonction musculaire ne soit pas toujours associée à la présence ou à l’absence d’IU. Aucune association n’a été trouvée entre la fonction des MPP et le type ou la gravité de l’IU. Ces résultats renforcent la nécessité de procéder à une évaluation bio-psycho-sociale de l’IU, qui ne se concentre pas uniquement sur la fonction des MPP. Les résultats rapportés ici peuvent être considérés comme une ressource pour des recherches plus spécifiques.
BibTeX:
@article{Audrain2024,
  author = {Audrain, Albane and Cornu, Jean Nicolas and Kerdelhue, Gaëtan and Combret, Yann and Steenstrup, Benoit},
  title = {Do pelvic floor muscle function parameters differ in women according to continence status? {A} systematic review},
  month = {March},
  journal = {The French Journal of Urology},
  year = {2024},
  volume = {34},
  number = {3},
  pages = {102592},
  url = {https://www.sciencedirect.com/science/article/pii/S2950393024000494},
  doi = {10.1016/j.fjurol.2024.102592}
}

Abstract: BACKGROUND: There are various Medical Subject Headings (MeSH) terms used to index general practice research, without consistency.
AIM: To understand how general practice-related research is indexed in the main general practice journals between 2011 and 2021, and to analyse the factors that influenced the choice of the general practice-related MeSH.
DESIGN AND SETTING: This was a quantitative bibliometric study conducted on MEDLINE.
METHOD: MeSH were selected according to the international definition of General Practice/Family Medicine: 'General Practice', 'Primary Health Care', 'Family Practice', 'General Practitioners', 'Physicians, Primary Care', and 'Physicians, Family'. Their use was studied from 2011 to 2021 on MEDLINE, reviewing the 20 general practice journals with the highest impact factors. A descriptive and analytical approach was used; the association of the country, journal, and year with the choice of general practice-related MeSH terms was analysed.
RESULTS: A total of 8514 of 150 286 articles (5.7 were using one of the general practice-related MeSH terms. The most used were 'Primary Health Care' (4648/9984, 46.6 and 'General Practice' (2841/9984, 28.5. A total of 80.0% (6172/7723) of the articles were related to the UK or US and 71.0% (6055/8514) of the articles came from four journals (BJGP, BMJ, Journal of General Internal Medicine, and Annals of Family Medicine). Two main country clusters emerged from the use of general practice-related MeSH: a British cluster mainly using 'General Practice' and an American cluster using 'Primary Health Care'. The journals also mainly differed in their used of these two MeSH terms.
CONCLUSION: Important variations in the indexation of general practice research were found. Researchers should consider combining 'Primary Health Care' and 'General Practice' in their PubMed searches to access all the general practice research, regardless of their country of origin.
BibTeX:
@article{Duguet2024,
  author = {Duguet, Théo and Ibanez, Gladys and Schuers, Matthieu and Lebeau, Jean-Pierre and Roser, Kristell and Gomes, Cécilia Saldanha and Cadwallader, Jean-Sébastien},
  title = {General practice-related {MeSH} terms in main journals: a bibliometric analysis from 2011 to 2021},
  month = {January},
  journal = {The British Journal of General Practice: The Journal of the Royal College of General Practitioners},
  year = {2024},
  pages = {BJGP.2023.0060},
  doi = {10.3399/BJGP.2023.0060}
}

Abstract: BACKGROUND: Prior studies showed that during the coronavirus disease 2019 (COVID-19) pandemic healthcare workers had a higher risk of developing post-traumatic stress disorder (PTSD) symptoms. However, studies conducted among doctors several years after the beginning of the COVID-19 pandemic are scarce.
AIMS: To evaluate the prevalence of PTSD among hospital doctors and to describe potential explanatory factors.
METHODS: The Protec-Cov study was an observational, cross-sectional, multicentre study, which used an anonymous online questionnaire to evaluate PTSD in doctors from six hospitals in France between December 2021 and March 2022. The presence of PTSD was assessed using the Post-traumatic Stress Disorder Checklist Scale (PCLS) questionnaire with a cut-off of 44.
RESULTS: Among the 307 doctors included, 18% presented a PCLS ≥44. The multivariate analysis showed that factors associated with a PCLS ≥44 were having a higher workload than before the COVID-19 pandemic (odds ratio [OR] = 4.75; 95% confidence interval [CI] 1.68-13.38), not feeling recognized within the professional environment (OR = 2.83; 95% CI 1.26-6.33), and feeling isolated because of the lockdown (OR = 4.2; 95% CI 1.97-8.95). Approximately 30% of hospital doctors (n = 91) felt a need for psychological support but only 31% of them (n = 28) received support.
CONCLUSIONS: Based on our findings, a high prevalence of PTSD was observed among hospital doctors 2 years after the beginning of the COVID-19 pandemic. This study supports an early diagnosis of PTSD in this category of healthcare workers and warrants further study.
BibTeX:
@article{Rollin2024,
  author = {Rollin, L. and Guerin, O. and Petit, A. and Bourdon, L. and Guillemette, S. and Gislard, A. and Clin, B. and Bachelet, L. and Rouget Mejjad, I. and Rouger, F. and Benichou, J. and Gehanno, J. F. and Commune, A.},
  title = {Post-traumatic stress disorder in hospital doctors after the {COVID}-19 pandemic},
  month = {February},
  journal = {Occupational Medicine (Oxford, England)},
  year = {2024},
  pages = {kqad125},
  doi = {10.1093/occmed/kqad125}
}

2023


Abstract: OBJECTIVE(S): Chronic kidney disease (CKD) is an insidious disease that requires early nephroprotective measures to delay progression to end-stage kidney disease. The objective of this study was to describe the management of patients with CKD in primary care, including clinical and biological monitoring and prescribed treatments. A retrospective, single-centre study was conducted on adult patients who were treated in the Maison de Neufchâtel (France) between 2012 and 2017 at least once a year. The inclusion criteria were 2 estimated glomerular filtration rate (eGFR) measurements textless60 mL/min more than 3 months apart. Two subgroups were constituted according to whether CKD was coded in the electronic medical records (EMRs).
RESULTS: A total of 291 (6.7 CI95% 5.9-7.4) patients with CKD were included. The mean eGFR was 51.0 ± 16.4 mL/min. Hypertension was the most frequent health problem reported (n = 93, 32. Nephrotective agents were prescribed in 194 (66.7 patients, non-steroidal anti-inflammatory drugs (NSAIDs) in 22 (8 patients, and proton-pump inhibitors (PPIs) in 147 (47 patients. CKD coding in EMRs was associated with dosage of natraemia (n = 34, 100 P textless 0.01), albuminuria (n = 20, 58 P textless 0.01), vitamin D (n = 14, 41 P textless 0.001), and phosphorus (n = 11, 32 P textless 0.001). Eighty-one patients (31.5 with low eGFR without an entered code for CKD were prescribed an albuminuria dosage. Clinical monitoring could not be analysed due to poor coding.
CONCLUSION: This pilot study reinforces the hypothesis that CKD is underscreened and undermanaged. More systematic coding of medical information in EMRs and further studies on medical centre databases should improve primary care practices.
BibTeX:
@article{Ariza2023,
  author = {Ariza, Matthieu and Martin, Steven and Dusenne, Mikaël and Darmon, David and Schuers, Matthieu},
  title = {Management of patients with chronic kidney disease: a {French} medical centre database analysis},
  month = {January},
  journal = {Family Practice},
  year = {2023},
  pages = {cmad004},
  doi = {10.1093/fampra/cmad004}
}

Abstract: OBJECTIVE: Planning reliable long-term planning actions to handle disruptive events requires a timely development of technological infrastructures, as well as the set-up of focused strategies for emergency management. The paper aims to highlight the needs for standardization, integration, and interoperability between Accident & Emergency Informatics (A&EI) and One Digital Health (ODH), as fields capable of dealing with peculiar dynamics for a technology-boosted management of emergencies under an overarching One Health panorama.
METHODS: An integrative analysis of the literature was conducted to draw attention to specific foci on the correlation between ODH and A&EI, in particular: (i) the management of disruptive events from private smart spaces to diseases spreading, and (ii) the concepts of (health-related) quality of life and well-being.
RESULTS: A digitally-focused management of emergency events that tackles the inextricable interconnectedness between humans, animals, and surrounding environment, demands standardization, integration, and systems interoperability. A consistent and finalized process of adoption and implementation of methods and tools from the International Standard Accident Number (ISAN), via findability, accessibility, interoperability, and reusability (FAIR) data principles, to Medical Informatics and Digital Health Multilingual Ontology (MIMO) - capable of looking at different approaches to encourage the integration between the ODH framework and the A&EI vision, provides a first answer to these needs.
CONCLUSIONS: ODH and A&EI look at different scales but with similar goals for converging health and environmental-related data management standards to enable multi-sources, interdisciplinary, and real-time data integration and interoperability. This allows holistic digital health both in routine and emergency events.
BibTeX:
@article{Benis2023,
  author = {Benis, Arriel and Haghi, Mostafa and Tamburis, Oscar and Darmoni, Stéfan J. and Grosjean, Julien and Deserno, Thomas M.},
  title = {Digital {Emergency} {Management} for a {Complex} {One} {Health} {Landscape}: the {Need} for {Standardization}, {Integration}, and {Interoperability}},
  month = {August},
  journal = {Yearbook of Medical Informatics},
  year = {2023},
  volume = {32},
  number = {1},
  pages = {27--35},
  doi = {10.1055/s-0043-1768742}
}

Abstract: AIMS: To describe the key elements of the interprofessional decision-making process in health, based on published scientific studies. To describe the authors, reviews and subject matter of those publications.
DESIGN: Scoping review of the literature.
DATA SOURCES: MEDLINE, APA Psycinfo OpenGrey, Lissa and Cochrane databases were searched in December 2019 and January 2023.
REVIEW METHODS: References were considered eligible if they (i) were written in French or English, (ii) concerned health, (iii) studied a clinical decision-making process, (iv) were performed in an interprofessional context. 'PRISMA-scoping review' guidelines were respected. The eligible studies were analysed and classified by an inductive approach RESULTS: We identified 1429 sources of information, 145 of which were retained for the analysis. Based on these studies, we identified five key elements of interprofessional decision-making in health. The process was found to be influenced by group dynamics, the available information and consideration of the unique characteristics of the patient. An organizational framework and specific training favoured improvements in the process.
CONCLUSION: Decision-making can be based on a willingness of the healthcare organization to promote models based on more shared leadership and to work on professional roles and values. It also requires healthcare professionals trained in the entire continuum of collaborative practices, to meet the unique needs of each patient. Finally, it appears essential to favour the sharing of multiple sources of accessible and structured information. Tools for knowledge formalization should help to optimize interprofessional decision-making in health.
IMPACT: The quality of a team decision-making is critical to the quality of care. Interprofessional decision-making can be structured and improved through different levels of action. These improvements could benefit to patients and healthcare professionals in every settings of care involving care collaboration.
IMPACT STATEMENT: Interprofessional decision-making in health is an essential lever of quality of care, especially for the most complex patients which are a contemporary challenge. This scoping review article offers a synthesis of a large corpus of data published to date about the interprofessional clinical decision-making process in healthcare. It has the potential to provide a global vision, practical data and a list of references to facilitate the work of healthcare teams, organizations and teachers ready to initiate a change.
BibTeX:
@article{Bouchez2023,
  author = {Bouchez, Tiphanie and Cagnon, Clémence and Hamouche, Gouraya and Majdoub, Marouan and Charlet, Jean and Schuers, Matthieu},
  title = {Interprofessional clinical decision-making process in health: {A} scoping review},
  month = {September},
  journal = {Journal of Advanced Nursing},
  year = {2023},
  doi = {10.1111/jan.15865}
}

Abstract: PURPOSE: This study aims to report on the effectiveness of various search strategies and keywords to find studies on work-related psychosocial risk factors (PRF) in the PubMed bibliographic database.
METHODS: We first selected by hand-searching 191articles published on PRF and indexed in PubMed. We extracted 30 relevant MeSH terms and 38 additional textwords. We then searched PubMed combining these 68 keywords and 27 general keywords on work-related factors. Among the 2953 articles published in January 2020, we identified 446 articles concerning exposure to PRF, which were gathered in a Gold Standard database. We then computed the Recall, Precision, and Number Needed to Read of each keyword or combination of keywords.
RESULTS: Overall, 189 search-words alone or in combination were tested. The highest Recall with a single MeSH term or textword was 43% and 35 respectively. Subsequently, we developed two different search strings, one optimizing Recall while keeping Precision acceptable (Recall 98.2 Precision 5.9 NNR 16.9) and one optimizing Precision while keeping Recall acceptable (Recall 73.1 Precision 25.5 NNR 9.7).
CONCLUSIONS: No single MeSH term is available to identify relevant studies on PRF in PubMed. Locating these types of studies requires the use of various MeSH and non-MeSH terms in combination to obtain a satisfactory Recall. Nevertheless, enhancing the Recall of search strategies may lead to lower Precision, and higher NNR, although with a non-linear trend. This factor must be taken into consideration when searching PubMed.
BibTeX:
@article{Gehanno2023a,
  author = {Gehanno, Jean-Francois and Thaon, Isabelle and Pelissier, Carole and Rollin, Laetitia},
  title = {Precision and {Recall} of {Search} {Strategies} for {Identifying} {Studies} on {Work}-{Related} {Psychosocial} {Risk} {Factors} in {PubMed}},
  month = {December},
  journal = {Journal of Occupational Rehabilitation},
  year = {2023},
  volume = {33},
  number = {4},
  pages = {776--784},
  doi = {10.1007/s10926-023-10110-w}
}

Abstract: BACKGROUND: Drug-related problems (DRPs) can lead to serious health issues and have significant economic impacts on healthcare systems. One solution to address this issue is the use of computerized physician order entry systems (CPOE), which can help prevent DRPs by reducing the risk of medication errors.
OBJECTIVE: The purpose of this study is to provide an analysis on scientific production of the past 20 years in order to describe trends in academic publishing on CPOE and to identify the major topics as well as the predominant actors (journals, countries) involved in this field.
METHODS: A PubMed search was carried out to extract articles related to computerized provider order entry during the period January 1st 2003- December 31st 2022 using a specific query. Data were downloaded from PubMed in Extensible Markup Language (XML) and were processed through a dedicated parser.
RESULTS: A total of 2,946 articles were retrieved among 623 journals. One third of these articles were published in eight journals. Publications grew strongly from 2002 to 2006, with a dip in 2008 followed by an increase again in 2009. After 2009, there follows a decreasing until 2022.The most producing countries are the USA with 51.39% of the publication over the period by France (3.80, and Canada (3.77. About disciplines, the top 3 is: "medical informatics" (21.62% of articles), "pharmacy" (19.04, and "pediatrics" (6.56.
DISCUSSION: This study provides an overview of publication trends related to CPOE, which exhibited a significant increase in the first decade of the 21st century followed by a decline after 2009. Possible reasons for this decline include the emergence of digital health tools beyond CPOE, as well as healthcare professionals experiencing alert fatigue of the current system.
CONCLUSION: Future research should focus on analyzing publication trends in the field of medical informatics and decision-making tools to identify other areas of interest that may have surpassed the development of CPOE.
BibTeX:
@article{Gosselin2023,
  author = {Gosselin, Laura and Leguillon, Romain and Rollin, Laetitia and Lejeune, Emeline and Darmoni, Stéfan J. and Grosjean, Julien},
  title = {Trends in computerized provider order entry: 20-year bibliometric overview},
  journal = {Frontiers in Digital Health},
  year = {2023},
  volume = {5},
  pages = {1217694},
  doi = {10.3389/fdgth.2023.1217694}
}

Abstract: BACKGROUND: French guidelines for the prevention of vascular access infections in a haemodialysis setting were released in 2005. Compliance with these guidelines is currently unknown. Our aim was to assess compliance with guidelines for vascular access infection prevention in French haemodialysis units, and to describe the difficulties reported.
METHODS: A cross-sectional survey was conducted between March and December 2019 in 200 haemodialysis units randomly selected in France. Data were collected via questionnaire, completed by telephone interview with an infection control practitioner. A practice was deemed compliant when textgreater 85% of units declared always complying with guidelines.
RESULTS: A total of 103 units (51.5 agreed to participate. Most practices complied with guidelines, however some of them (working in pairs when connecting central venous catheter (CVC) lines, performing hand hygiene before disconnecting lines, rinsing antiseptic soap before painting CVC exit site or arteriovenous fistula (AVF) puncture site, allowing antiseptic paint to dry, handling CVC branches with antiseptic impregnated gauze, performing hand hygiene after AVF compression with gloves, wearing protective eyewear when connecting/disconnecting CVC or when puncturing AVF, wearing a gown when puncturing AVF) did not reach the 85% compliance threshold. Most frequently reported difficulties were understaffing, difficulties with skin preparation because of exit site skin damage, and lack of buttonhole technical expertise.
CONCLUSIONS: Despite good overall compliance, this survey highlights some shortcomings in complying with infection prevention guidelines, which could be associated with either higher vascular access infection risk or with increased blood-borne virus transmission.
BibTeX:
@article{Habihirwe2023,
  author = {Habihirwe, Philbert and Marini, Hélène and Wurtz, Blandine and Vermeulin, Thomas and Lottin, Marion and Gehanno, Jean François and Boulet, Ludivine and Vergnes, Hervé and Edet, Stéphane and Guet, Laurence and Le Roy, Frank and Merle, Véronique},
  title = {Compliance with good practice guidelines for the prevention of vascular access infections: {The} multicentre {PHYDEL} survey in {French} haemodialysis units},
  month = {September},
  journal = {The Journal of Hospital Infection},
  year = {2023},
  pages = {S0195--6701(23)00294--3},
  doi = {10.1016/j.jhin.2023.09.007}
}

Abstract: PURPOSE: Studies in the United States, Canada, Belgium, and Switzerland showed that the majority of health problems are managed within primary health care; however, the ecology of French medical care has not yet been described.
METHODS: Nationwide, population-based, cross sectional study. In 2018, we included data from 576,125 beneficiaries from the General Sample of Beneficiaries database. We analysed the reimbursement of consultations with (i) a general practitioner (GP), (ii) an outpatient doctor other than a GP, (iii) a doctor from a university or non-university hospital; and the reimbursement of (iv) hospitalization in a private establishment, (v) general hospital, and (vi) university hospital. For each criterion, we calculated the average monthly number of reimbursements reported on 1,000 beneficiaries. For categorical variables, we used the χ2 test, and to compare means we used the z test. All tests were 2-tailed with a P-value textless 5% considered significant.
RESULTS: Each month, on average, 454 (out of 1,000) beneficiaries received at least 1 reimbursement, 235 consulted a GP, 74 consulted other outpatient doctors in ambulatory care and 24 in a hospital, 13 were hospitalized in a public non-university hospital and 10 in the private sector, and 5 were admitted to a university hospital. Independently of age, people consulted GPs twice as much as other specialists. The 13-25-year-old group consulted the least. Women consulted more than men. Individuals covered by complementary universal health insurance had more care.
CONCLUSIONS: Our study on reimbursement data confirmed that, like in other countries, in France the majority of health problems are managed within primary health care.
BibTeX:
@article{Laporte2023,
  author = {Laporte, Catherine and Fortin, Frédéric and Dupouy, Julie and Darmon, David and Pereira, Bruno and Authier, Nicolas and Delorme, Jessica and Chenaf, Chouki and Maisonneuve, Hubert and Schuers, Matthieu},
  title = {The {French} ecology of medical care. {A} nationwide population-based cross sectional study},
  month = {November},
  journal = {Family Practice},
  year = {2023},
  pages = {cmad098},
  doi = {10.1093/fampra/cmad098}
}

BibTeX:
@article{Leguillon2023,
  author = {Leguillon, Romain and Gosselin, Laura and Carnoy, Christophe and Pressat-Laffouilhere, Thibaut and Letord, Catherine and Dahamna, Badisse and Darmoni, Stéfan J. and Grosjean, Julien},
  title = {Integrating a new knowledge organisation system for monoclonal antibodies for therapeutic use authorised in {Europe} into {HeTOP} {Terminology}-{Ontology} {Server}},
  month = {March},
  journal = {Journal of Biomedical Informatics},
  year = {2023},
  pages = {104325},
  url = {https://linkinghub.elsevier.com/retrieve/pii/S1532046423000461},
  doi = {10.1016/j.jbi.2023.104325}
}

Abstract: INTRODUCTION: Clinical pharmacist (CP) intervention improves drug prescription by identifying potentially inappropriate prescriptions (PIPs). Geriatric perioperative care units (UPOGs) provide enhanced care for patients with hip fracture, including drug prescription. However, it is not known whether adding a CP intervention in a UPOG decreases the number of PIPs. This study aimed to evaluate the effect of a CP intervention, combining an implicit and an explicit method, on the number of PIPs in a UPOG.
METHODS: This single centre before-after-control-impact study recruited patients aged over 75 years admitted to a UPOG for a hip fracture. The "control group" ("before period") received usual care including two medication reconciliations, one at admission and one at discharge. The "intervention group" ("after period") received usual care and a CP intervention including two medication reconciliations, a medication review with two tools, STOPP/START and Medication Appropriateness Index, and a meeting between a CP and geriatricians. PIPs were assessed in both groups by STOPP/START and Medication Appropriateness Index and compared from hospital admission to discharge.
RESULTS: A total of 209 patients were included, 150 in the control group and 59 in the intervention group (mean age: 87.2 ± 5.9 years). The number of PIPs decreased in both groups from hospital admission to discharge (p textless 0.001). The number of PIPs, potentially inappropriate medications, and potential prescribing omissions decreased more in the intervention group than in the control group (adjusted intervention effect: -2.46 (95% CI: -2.63; -2.24); -1.13 (95% CI: -1.27; -0.98); and -1.35 (95% CI: -1.52; -1.18), respectively, p textless 0.001 for all).
DISCUSSION/CONCLUSION: A CP intervention with an explicit and implicit method improved prescriptions in a UPOG. Further randomized studies are necessary to evaluate the effect of a CP intervention on adverse drug events, health costs, and mortality.
BibTeX:
@article{Leguillon2023a,
  author = {Léguillon, Romain and Varin, Rémi and Pressat-Laffouilhère, Thibaut and Chenailler, Catherine and Chassagne, Philippe and Roca, Frédéric},
  title = {Clinical {Pharmacist} {Intervention} {Reduces} {Potentially} {Inappropriate} {Prescriptions} in a {Geriatric} {Perioperative} {Care} {Unit} {Dedicated} to {Hip} {Fracture}},
  journal = {Gerontology},
  year = {2023},
  volume = {69},
  number = {4},
  pages = {386--395},
  doi = {10.1159/000526595}
}

Abstract: BACKGROUND: Omalizumab (OMA) dramatically improves disease control and quality of life in patients with chronic urticaria (CU).
OBJECTIVE: We aimed to evaluate the discontinuation patterns of OMA and their determinants in a cohort of French patients with CU.
METHODS: We conducted a retrospective multicenter study in nine French tertiary referral hospitals. All patients diagnosed with either spontaneous (CSU) and/or inducible (CIndU) CU who received at least one injection of OMA between 2009 and 2021 were included. We analyzed OMA drug survival and investigated possible determinants using Kaplan-Meier curves and log-rank tests.
RESULTS: A total of 878 patients were included in this study; 48.8% had CSU, 10.1% CIndU, and 41.1% a combination of both. OMA was discontinued in 408 patients but the drug was later reintroduced in 50% of them. The main reason for discontinuing treatment was the achievement of a well-controlled disease in 50% of patients. Half of the patients were still being treated with OMA 2.4 years after the initiation of treatment. Drug survival was shorter in patients with CIndU and in those with an autoimmune background. In atopic patients, OMA was discontinued earlier in patients achieving a well-controlled disease. A longer OMA drug survival was observed in patients with a longer disease duration at initiation.
CONCLUSION: In French patients with CU, the drug survival of OMA appears to be longer than that observed in previous studies conducted elsewhere, highlighting discrepancies in prescription and reimbursement possibilities. Further studies are warranted to develop customized OMA treatment schemes based on individual patterns.
BibTeX:
@article{Litovsky2023,
  author = {Litovsky, Julie and Hacard, Florence and Tetart, Florence and Boccon-Gibod, Isabelle and Soria, Angele and Staumont-Salle, Delphine and Doutre, Marie-Sylvie and Amsler, Emmanuelle and Mansard, Catherine and Dezoteux, Frederic and Darrigade, Anne-Sophie and Milpied, Brigitte and Bernier, Claire and Perrot, Jean-Luc and Raison-Peyron, Nadia and Paryl, Marie and Droitcourt, Catherine and Demoly, Pascal and Grosjean, Julien and Mura, Thibault and Du-Thanh, Aurelie and study group of French Dermatology Society, Urticaria},
  title = {Omalizumab drug survival in chronic urticaria: a retrospective multicentric {French} study},
  month = {August},
  journal = {The Journal of Allergy and Clinical Immunology. In Practice},
  year = {2023},
  pages = {S2213--2198(23)00956--X},
  doi = {10.1016/j.jaip.2023.08.033}
}

Abstract: INTRODUCTION: Acute respiratory infections (ARIs) are the most common viral infections encountered in primary care settings. The identification of causal viruses is still not available in routine practice. Although new strategies of prevention are being identified, knowledge of the relationships between respiratory viruses remains limited.
MATERIALS AND METHODS: ECOVIR was a multicentric prospective study in primary care, which took place during two pre-pandemic seasons (2018-2019 and 2019-2020). Patients presenting to their General practitioner (GP) with ARIs were included, without selecting for age or clinical conditions. Viruses were detected on nasal swab samples using a multiplex Polymerase Chain Reaction test focused on 17 viruses [Respiratory Syncytial Virus-A (RSV-A), RSV-B, Rhinovirus/Enterovirus (HRV), human Metapneumovirus (hMPV), Adenovirus (ADV), Coronaviruses (CoV) HKU1, NL63, 229E, OC43, Influenza virus (H1 and H3 subtypes), Influenza virus B, Para-Influenza viruses (PIVs) 1-4, and Bocavirus (BoV)].
RESULTS: Among the 668 analyzed samples, 66% were positive for at least one virus, of which 7.9% were viral codetections. The viral detection was negatively associated with the age of patients. BoV, ADV, and HRV occurred more significantly in younger patients than the other viruses (p textless 0.05). Codetections were significantly associated with RSV, HRV, BoV, hMPV, and ADV and not associated with influenza viruses, CoV, and PIVs. HRV and influenza viruses were negatively associated with all the viruses. Conversely, a positive association was found between ADV and BoV and between PIVs and BoV.
CONCLUSION: Our study provides additional information on the relationships between respiratory viruses, which remains limited in primary care.
BibTeX:
@article{Petat2023,
  author = {Petat, Hortense and Schuers, Matthieu and Marguet, Christophe and Humbert, Xavier and Le Bas, François and Rabiaza, Andry and Corbet, Sandrine and Leterrier, Bryce and Vabret, Astrid and Ar Gouilh, Meriadeg},
  title = {Positive and negative viral associations in patients with acute respiratory tract infections in primary care: the {ECOVIR} study},
  journal = {Frontiers in Public Health},
  year = {2023},
  volume = {11},
  pages = {1269805},
  doi = {10.3389/fpubh.2023.1269805}
}

Abstract: BACKGROUND: The management of adult male urinary tract infections (mUTIs) in primary care lacks international consensus. The main objective of this study was to describe the different guidelines for the diagnosis and management of mUTIs in primary care, to assess their methodological quality, and to describe their evidence-based strength of recommendation (SoR).
METHODS: An international systematic literature review of the electronic databases Medline (PubMed) and EMBASE, and gray-literature guideline-focused databases was performed in 2021. The Appraisal of Guidelines for Research and Evaluation (AGREE II) assessment tool was used by 2 independent reviewers to appraise each guideline.
RESULTS: From 1,678 records identified, 1,558 were screened, 134 assessed for eligibility, and 29 updated guidelines met the inclusion criteria (13 from Medline, 0 from EMBASE, and 16 from gray literature). Quality assessment revealed 14 (48 guidelines with high-quality methodology. A grading system methodology was used in 18 (62 guidelines. Different classifications of mUTIs are described, underlining a lack of international consensus: an anatomic classification (cystitis, prostatitis, pyelonephritis) and a symptomatic classification (approach based on the intensity and tolerance of symptoms). The duration of antibiotic treatment for febrile mUTIs has been gradually reduced over the last 20 years from 28 days to 10-14 days of fluoroquinolones (FQ), which has become the international gold standard. Guidelines from Scandinavian countries propose short courses (3-5 days) of FQ-sparing treatments: pivmecillinam, nitrofurantoin, or trimethoprim. Guidelines from French-speaking countries use a watchful waiting approach and suggest treating mUTIs with FQ, regardless of fever.
CONCLUSIONS: This lack of scientific evidence leads to consensus and disagreement: 14 days of FQ for febrile mUTIs is accepted despite a high risk of antimicrobial resistance, but FQ-sparing treatment and/or short treatment for afebrile mUTIs is not. The definition of afebrile UTIs/cystitis is debated and influences the type and duration of antibiotic treatment recommended.
BibTeX:
@article{Soudais2022,
  author = {Soudais, Benjamin and Ribeaucoup, Florian and Schuers, Matthieu},
  title = {Guidelines for the management of male urinary tract infections in primary care: a lack of international consensus-a systematic review of the literature},
  month = {February},
  journal = {Family Practice},
  year = {2023},
  volume = {40},
  number = {1},
  pages = {152-175},
  doi = {10.1093/fampra/cmac068}
}

Abstract: Résumé
Introduction
La carrière professionnelle peut être modifiée par des problèmes de santé. L'altération professionnelle, notifiée par le médecin du travail, peut être suivie d'une recherche de reclassement ou d'une désinsertion professionnelle.
Objectifs
Décrire le profil des travailleurs déclarés inaptes à leur poste de travail et décrire le profil de ceux qui n'ont pas de capacité de travail restante (CTR).
Méthodes
Population de travailleurs suivie par un service de santé au travail interentreprises de 20 médecins du travail. Les caractéristiques des travailleurs déclarés inaptes à leur poste de travail ont été extraites des dossiers médicaux (âge, sexe, secteur d'activité (Naf), catégorie socioprofessionnelle (PCS), pathologie entraînant une déficience professionnelle (CIM10), statut d'obligation d'emploi de travailleurs handicapés (BOETH). Les facteurs associés à l'inaptitude au travail dû à l'absence de capacité de travail restante (CTR) ont été identifiés par des modèles de régression logistique.
Résultats
En 2019, 82 678 travailleurs ont été suivis par le SPSTI et 554 travailleurs ont été déclarés inaptes à leur poste de travail par le médecin du travail (0,67 % des travailleurs), dont 162 n'avaient pas de CTR. Les taux d'inaptitude étaient les plus importants chez les femmes et les travailleurs de plus de 55 ans. Les pathologies psychiques (29 et rhumatologiques (50 étaient plus souvent à l'origine de l'inaptitude professionnelle. Le statut BOETH a été identifié pour 63 % des travailleurs. Les facteurs significativement associés à l'absence de CTR étaient l'âge textgreater 45 ans et la pathologie psychique, alors que le sexe, le secteur d'activité et la PCS ne l'étaient pas.
Discussion
Aucune administration publique ne recense l'ensemble des inaptitudes professionnelles en France. Les études antérieures ont décrit le profil des travailleurs inaptes à leur poste de travail mais aucune n'a décrit le profil de ceux qui n'ont pas de CTR. Ces travailleurs sont pourtant exposés à un risque élevé de précarité.
Conclusions
Les pathologies psychiques sont les pathologies qui génèrent le plus d'inaptitudes professionnelles sans CTR. La prévention de ces pathologies est essentielle. Les pathologies rhumatologiques sont la première cause d'inaptitude au poste de travail mais la proportion de travailleurs sans CTR est moins importante. Celles-ci peuvent être en relation avec les efforts déployés pour le retour au travail de ces patients.
BibTeX:
@article{Courtois2023,
  author = {Courtois, R. and Couvreur, M. and Gehanno, J. F. and Rollin, L.},
  title = {Analyse du profil des salariés déclarés inaptes au poste de travail : quelle place pour les facteurs sociétaux ou extra-professionnels et quelles conséquences sur l'emploi ?},
  month = {August},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2023},
  volume = {71},
  number = {4},
  pages = {102089},
  url = {https://www.sciencedirect.com/science/article/pii/S0398762023006740},
  doi = {10.1016/j.respe.2023.102089}
}

Abstract: L’accès aux revues médicales scientifiques est indispensable pour les médecins ou les paramédicaux qui souhaitent maintenir à jour leurs connaissances, se documenter pour la prise en charge d’un patient ou s’engager dans des travaux de recherche. Au-delà des outils anglo-saxons (Pub-Med, Google Scholar) qui impliquent de réaliser la recherche documentaire en anglais et qui listent principalement des ressources en anglais, il existe des outils qui permettent une recherche en français et couvrent des ressources en français de façon beaucoup plus complète que les outils anglosaxons. Nous présentons tout d’abord le portail en français CISMeF (Catalogue et Index des sites médicaux de langue française) ouvrant l’accès à une base de données centrée sur les ressources Internet médicales en français (doc’CISMEF) et sur la base LiSSa (Littérature scientifique médicale francophone en santé), tous deux utilisant un moteur de recherche en français : HeTOP (Health Terminology/Ontology Portal). D’autres bases de données et moteurs de recherche en français sont ensuite présentés, soit généralistes (Summon, Wikipédia Encyclopédie médicale), soit spécialisés (Recomedical, VIDAL, Orphanet, Agents tératogènes). Ils sont pour la plupart interfacés et reliés à PubMed. Leur utilité au quotidien nous paraît indiscutable que ce soit pour la recherche documentaire « à froid », mais aussi directement pour la prise en charge des patients au cabinet ou à l’hôpital.
BibTeX:
@article{Joly2023,
  author = {Joly, L.-M. and Leroy, J.-P. and Roussel, M. and Darmoni, S.},
  title = {Bases de données médicales scientifiques et moteurs de recherche en français},
  journal = {Annales françaises de médecine d’urgence},
  year = {2023},
  note = {Publisher: Lavoisier},
  url = {https://afmu.revuesonline.com/articles/lvafmu/abs/first/lvafmu_2023_sprurge001293/lvafmu_2023_sprurge001293.html},
  doi = {10.3166/afmu-2022-0459}
}

Abstract: Les recommandations récentes de l’ESC introduisent la possibilité de réaliser des cycles rapides de troponine dans le cadre d’une suspicion d’un SCA ST-. Ces recommandations offrent la possibilité d’utilisation de systèmes délocalisés sous réserve qu’ils aient une grande sensibilité analytique. L’objectif de notre étude est d’évaluer en vie réelle la faisabilité et les performances d’un dosage de troponine I-hs (TnI-hs, Atellica® VTLi, Siemens) délocalisé comparé aux valeurs obtenues de troponine T-hs (TnT-hs, e602®, Roche) pour des patients consultant dans un service d’urgences. Les CV de répétabilité et reproductibilité de la TnI-hs sont inférieurs à 10 %. La comparaison des deux troponines est modérée (r = 0,7). Les 117 patients inclus dans l’étude ont un âge médian de 65 ans, 30 % sont insuffisants rénaux et 36 % consultent pour douleur thoracique. Dans notre étude, la TnT-hs est plus souvent supérieure au 99e percentile que la TnI-hs et ceux même pour un 99e percentile de TnT-hs adapté à l’âge. La concordance des résultats est modérée (Kappa de Cohen : 0,54), l’âge restant la valeur explicative la plus importante des discordances. Seule la TnT-hs présente une valeur prédictive concernant l’hospitalisation. Nous n’avons pas observé de discordances d’interprétation pour les patients ayant eu une cinétique de troponine. Cette étude conforte la faisabilité d’utiliser un système de biologie délocalisée aux urgences sous réserve qu’il réalise une troponine hypersensible. Cependant, des données sont manquantes pour pouvoir l’utiliser dans le cadre d’algorithme rapide. Enfin, cette implémentation nécessite une collaboration clinico-biologique étroite tant sur l’organisation que sur l’interprétation des valeurs afin d’améliorer le service médical rendu au patient.
BibTeX:
@article{Mottin2023,
  author = {Mottin, Léo and Kassimy, Iliasse Idrissi and Girot, Hélène and Leguillon, Romain and Joly, Luc Marie and Brunel, Valery},
  title = {Évaluation en vie réelle de la mesure de troponine {I} hypersensible sur un système de biologie délocalisée pour un service d’urgences},
  month = {May},
  journal = {Annales De Biologie Clinique},
  year = {2023},
  volume = {81},
  number = {2},
  pages = {145--155},
  url = {https://www.jle.com/fr/revues/abc/e-docs/evaluation_en_vie_reelle_de_la_mesure_de_troponine_i_hypersensible_sur_un_systeme_de_biologie_delocalisee_pour_un_service_durgences_330643/article.phtml},
  doi = {10.1684/abc.2023.1804}
}

Abstract: Industrie en plein essor, le secteur de la logistique est soumis à une forte sinistralité en termes d’accidents du travail et de maladies professionnelles. Notre objectif était de décrire les conditions de travail et l’état de santé des travailleurs du secteur de la logistique en les comparant avec les salariés des autres secteurs professionnels.
Méthodes
Une étude épidémiologique descriptive a été réalisée à partir des données des enquêtes Sumer 2010 et 2017 et de l’observatoire Evrest (2008–2012 et 2013–2017).
Résultats
Les métiers de la logistique comportent une charge physique omniprésente incluant plus de manutention manuelle de charge et de contraintes articulaires que dans les autres secteurs professionnels. Additionnés à un travail en ambiance froide et soumis aux vibrations des engins de manutention, une prévalence importante d’atteintes du rachis et des membres supérieurs est mise en évidence chez les salariés de la logistique. Le bruit des entrepôts et l’utilisation de la commande vocale sont source de fatigue auditive. D’autre part, ils présentent une faible latitude décisionnelle découlant d’une organisation de travail rigide avec une préparation des commandes à flux tendu et des délais stricts à respecter pour répondre aux exigences croissantes des clients. Pourtant, en partie grâce à un fort soutien social, leur santé mentale reste préservée. Il n’est pas retrouvé plus d’arrêts ou d’accidents du travail que dans les autres secteurs mais notre méthode ne permettait pas d’inclure les travailleurs intérimaires qui représentent jusqu’à 30 % des effectifs en logistique.
Conclusion
Afin d’approfondir nos connaissances sur le secteur de la logistique, il conviendrait de développer un suivi longitudinal des salariés, ciblé par métier et intégrant les salariés intérimaires, pour préciser les risques psychosociaux et leur conséquence sur la survenue de troubles musculosquelettiques et sur la sinistralité du secteur.
BibTeX:
@article{Naili2023,
  author = {Naïli, M. and Fort, E. and Rollin, L. and Leroyer, A. and Gavoille, A. and Desbas, A. and Charbotel, B.},
  title = {Évaluation des conditions de travail et de l’état de santé des travailleurs en entrepôts et plateformes logistiques},
  month = {June},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2023},
  volume = {84},
  number = {3},
  pages = {101669},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878522003320},
  doi = {10.1016/j.admp.2022.10.001}
}

Abstract: Objectifs
Évaluer rétrospectivement le taux de salariés, confinés (en télétravail) et non confinés, infectés par le SARS-CoV-2 après le 1er confinement (avril à mai 2020).

Méthode
Un dépistage sérologique des anticorps anti-SARS-CoV-2, IgG et IgM, et un questionnaire sur leurs symptômes a été proposé aux 2090 salariés d’une même entreprise.

Résultats
La sérologie était positive pour 5,6 % des 786 salariés inclus entre fin avril et juillet 2020 : 4,05 % chez les non confinés, et 6,72  chez les confinés (p = NS). Parmi les positifs, 86,4 % avaient présenté des symptômes, sans différence significative entre confinés et non confinés. Enfin, 1,7 % des asymptomatiques étaient positifs. Les symptômes n’étaient pas significativement différents entre les 2 groupes sauf pour l’anosmie-agueusie significativement plus fréquente dans le groupe des confinés. Les symptômes significativement associés à une sérologie positive étaient l’anosmie-agueusie, la fièvre-sensation de fièvre-frissons, les courbatures, la fatigue malaise, un syndrome grippal et des symptômes respiratoires. Ce faible taux de contamination peut être le résultat des mesures de prévention renforcées mises en place pour les salariés dès fin janvier 2020 par le médecin du travail pour limiter le risque de contamination au sein des locaux.

Conclusion
La prévalence du SARS-CoV-2 dans l’entreprise de fin avril à juillet 2020 était inférieure de moitié au taux rapporté dans la population d’Ile de France à la même période sans différence entre les salariés ayant poursuivi leur activité en présentiel par rapport aux confinés.
BibTeX:
@article{Sauvage2023,
  author = {Sauvage, E. and Gehanno, J. F. and Thomas, N. and Rollin, L.},
  title = {Prévalence du {SARS}-{CoV}-2, étude sérologique en {France} chez des salariés non confinés et confinés},
  month = {August},
  journal = {Archives Des Maladies Professionnelles et De L'Environnement},
  year = {2023},
  volume = {84},
  number = {4},
  pages = {101798},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892330/},
  doi = {10.1016/j.admp.2023.101798}
}

Abstract: The national teleconsultation platform Qare offers a promising tool to collect data in primary care by sharing the same EHR among teleconsultants. Conclusions for every teleconsultation are thus collected by a text using an ICD10 code or not. Nevertheless, the use of the ICD10 classification by primary care doctors is scarce. We developed an algorithm based on bags of words that associates an ICD10 code for each textual conclusion and evaluated it. It shows good performances (88 to 89% concordance) to assign ICD10 category. It could be used to enhance the volume of coded teleconsultations ready to be reused.
BibTeX:
@inproceedings{Melot2023,
  author = {Melot, Bénédicte and Drouet, Florian and Alvarez, Caroline and Grimshaw, Céline and Grosjean, Julien and Duclos, Catherine},
  title = {Automated {ICD10}-{Coding} of {Teleconsultations} {Conclusions} in {Primary} {Care}},
  booktitle = {Studies in {Health} {Technology} and {Informatics}},
  month = {October},
  publisher = {IOS Press},
  year = {2023},
  url = {https://ebooks.iospress.nl/doi/10.3233/SHTI230758},
  doi = {10.3233/SHTI230758}
}

BibTeX:
@article{Angelozzi2023,
  author = {Angelozzi, L. and Gillibert, A. and Grosjean, J. and Brevet, P. and Jouen, F. and Lequerré, T. and Vittecoq, O.},
  title = {Analyse comparative du profil clinique, de la prise en charge thérapeutique et du pronostic sous traitement des patients atteints d’une polyarthrite rhumatoïde immunopositive ou immunonégative après l’introduction d’une première thérapie ciblée},
  month = {December},
  journal = {Revue du rhumatisme},
  year = {2023},
  volume = {90},
  pages = {A91--A92},
  url = {https://www.lissa.fr/fr/rep/articles/EL_S1169833023005124},
  doi = {10.1016/j.rhum.2023.10.139}
}

Abstract: Introduction
Dans un contexte de crise des opioïdes mondiale qui touche préférentiellement les États-Unis, la France est le troisième pays européen en 2015 consommateur d’opioïdes faibles au premier rang desquels figure le tramadol [1]. L’objectif principal est de dresser un état des lieux des habitudes de prescription du tramadol chez les rhumatologues français. L’objectif secondaire est de vérifier si leurs habitudes de prescriptions sont en accord avec les recommandations HAS de mars 2022 sur le bon usage des opioïdes notamment sur son utilisation en dernière intention dans la prise en charge de certaines douleurs chroniques : lombalgie, lomboradiculalgie ou arthrose [2].
Matériels et méthodes
Pour répondre à l’objectif principal, nous avons adressé en juillet 2022 via la mailing-list de la SFR, un questionnaire de 46 questions recueillant les habitudes de prescription des rhumatologues français en collaboration avec le Cercle d’étude de la douleur en rhumatologie. En complément, les prescriptions du tramadol de la base de données du Système national des données de santé (SNDS) ont été extraites. Pour répondre à l’objectif secondaire, nous avons comparé les données déclarées des prescriptions avec les recommandations HAS 2022 sur le bon usage des opioïdes [2].
Résultats
Concernant les résultats du questionnaire : 296 rhumatologues ont rempli le questionnaire sur les 1760 sollicités. Ils prescrivent principalement du tramadol pour les radiculalgies et rachialgies aiguës alors que les radiculalgies et rachialgies chroniques arrivent en 4e et 5e positions des indications. 22,3 % prescrivent du tramadol en situation de douleur chronique en l’absence de diagnostic étiologique. L’association tramadol/paracétamol est la forme pharmaceutique la plus prescrite (68,1 % des répondants). 45,3 % utilisent une Échelle Visuelle Analogique ou Numérique dans un contexte de douleur chronique. 74,4 % fixent une durée de prescription au-delà de laquelle, sans bénéfice pour le patient, le traitement est interrompu et/ou une consultation spécialisée douleur est organisée. 31 % déclarent ne pas avoir de freins par rapport à la prescription de tramadol. 52 % ne connaissent pas les recommandations HAS 2022 [2]. Concernant les résultats du SNDS : entre 2016 et 2022, on note une diminution de : 40 % des prescriptions de tramadol par les rhumatologues (65 543 vs 40 905) et 47 % des prescriptions de tramadol associé au paracétamol (83 032 vs 43 311).
Conclusion
Dans le contexte de crise des opioïdes, la France fait figure de bon élève avec une mortalité par surdoses d’opioïdes parmi les plus faibles des pays membres de l’OCDE (d’après Obradovic et al.). Cela est cohérent avec la tendance actuelle à la diminution de la prescription de tramadol par les médecins généralistes et surtout par les rhumatologues. La prescription de tramadol par les rhumatologues français est raisonnée.
BibTeX:
@article{Bibaut2023,
  author = {Bibaut, L. and Lacroix, E. and Grosjean, J. and Bernard, A. and Jansseune, Q. and Lequerré, T. and Vittecoq, O. and Pouplin, S.},
  title = {État des lieux de la prescription du tramadol pour les douleurs en rhumatologie par les rhumatologues français},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2023},
  series = {36e {Congrès} {Français} de {Rhumatologie}},
  volume = {90},
  pages = {A13--A14},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833023003927},
  doi = {10.1016/j.rhum.2023.10.019}
}

Abstract: Introduction (contexte de la recherche)
L’œsophagite à éosinophiles (EoE) a une physiopathologie encore incomplètement comprise. Sa présence accrue chez les patients atopiques et également chez des patients sans antécédent atopique fait suggérer l’existence de phénotypes cliniques et physiopathologiques différents.
Objectif
Évaluer l’implication de l’allergie notamment alimentaire dans l’EoE en recherchant l’existence de plusieurs phénotypes d’EoE : allergique (A) et non allergique (nA) selon différents immunomarquages.
Méthodes
Étude rétrospective sur 20ans, monocentrique, non interventionnelle (Hors Loi Jardé), validée par l’EDSaN et par la CNIL (n° 2021/0363/OB). Étude des données démographiques, clinico-biologiques des patients atteints d’EoE. Des marquages immunohistochimiques (CD3, CD117/KIT, tryptase, IL5) ont été réalisés sur biopsies d’EoE et sur tissus de patients témoins (×10). Les patients étaient classés selon différents groupes : (A)/Atopique seul ; A/Induit à l’aliment et nA. Les tests de Mann-Whitney et de Fischer ont été utilisés selon le type de variable, seuil de significativité corrigé au nb de comparaison (p valuetextless0,002) et réalisation d’une analyse en composante principale.
Résultats
Démographie : 82 patients ont été inclus (26 A dont 8 induit à l’aliment et 18 atopique seul et 56 nA). Immunomarquages : le comptage des immunomarquages CD3, CD117/KIT, tryptase, IL5 était significativement plus important dans les groupes A que nA (respectivement : 57 (22,2) vs 42,3 (18,5), p : 0,003 ; 11,1 (9,7) vs 5,2 (4,9), ptextless0,001 ; 16,3 (9) vs 4,9 (2,6), ptextless0,001 ; 1,9 (2,5) vs 0,05 (0,3), ptextless0,001). De même, le comptage était significativement plus important au sein du sous-groupe Induit par l’aliment versus les nA. Enfin le sous-groupe Induit à l’aliment montrait également un marquage plus important que le sous-groupe atopique, en ce qui concerne les marqueurs CD117/KIT et IL5, respectivement (18,3 (12,9) vs 7,9 (6,1), p : 0,002 ; 2,8 (1,7) vs 1,4 (2,7), p : 0,031).
Conclusions
Nos résultats appuient une différence phénotypique dans l’EoE ouvrant la question sur des différences physiopathologiques entre les patients A / Induit par l’aliment par rapport aux autres patients (nA et A / Atopique seul).
BibTeX:
@article{Lagassy2023,
  author = {Lagassy, M. and Pressat Laffouilhere, T. and Grosjean, J. and Leblond, L. and Dordain, S. and Mahay, G. and Couderc, L. and Dumant-Forest, C. and Sabourin, J. C. and Martinet, J. and Coëffier, M.},
  title = {Résultats préliminaires de l’étude {Profil}-{Eo} : différents profils d’œsophagite à éosinophiles (allergique et non allergique) selon de multiples immunomarquages tissulaires},
  month = {April},
  journal = {Revue Française d'Allergologie},
  year = {2023},
  series = {18e {Congrès} {Francophone} d'{Allergologie}},
  volume = {63},
  number = {3},
  pages = {103385},
  url = {https://www.sciencedirect.com/science/article/pii/S1877032023001094},
  doi = {10.1016/j.reval.2023.103385}
}

Abstract: Introduction
Les cathéters intra veineux de longue durée (CIVLD) sont des dispositifs fréquents. Les bactériémies liées aux CIVLD sont une des principales complications. L'objectif principal de cette étude est de mesurer l'efficacité des verrous antibiotiques pour le traitement des bactériémies liées aux CIVLD. Les objectifs secondaires sont d'estimer la mortalité liée à l'infection de CIVLD, la mortalité toute cause et de trouver d'éventuels facteurs pronostics.
Matériels et méthodes
Il s'agit d'une étude rétrospective incluant l'ensemble des patients traités dans notre centre hospitalo-universitaire pour une bactériémie liée aux CIVLD entre 2014 et 2022. Les critères diagnostics ont été défini selon les dernières recommandations de la Société de Pathologie Infectieuse de Langue Française (SPILF). L'ensemble des patients ont été traité et suivi selon un protocole standardisé locale. La guérison était définie par la stérilité des hémocultures de contrôle associée à l'amendement des signes cliniques et à l'absence de rechute ou du retrait du cathéter à cause d'une infection à 1 mois de la fin du traitement. Les décès non liés au traitement étaient censurés.
Résultats
Un total de 60 épisodes concernant 58 patients ont été inclus dont 51 ont pu être suivi jusqu'à M1. Les CIVLD étaient utilisés pour l'administration de chimiothérapie (44/60 épisodes, 73 d'alimentation parentérale (6/60, 10, pour un usage mixte (7/60, 12 ou pour un autre usage (3/60, 5. La culture microbiologique mettait en évidence un Staphylocoque à coagulase-négative dans 43% des cas (26/60), une enterobactérie dans 37% des cas (22/60 épisodes), un Pseumononas. aeruginosa dans 8% des cas (5/60), ou une infection polymicrobienne dans 8% des cas (5/60). Le taux d'échec de traitement était de 37% (19/51) parmi les patients ayant complété le suivi. La mortalité toute cause était de 239/51), la mortalité liée à l'infection de CIVLD était de 32/51). Les patients traités pour un cancer solide ou ceux en traitement palliatif avaient un taux d'échec significativement plus élevé (respectivement, p=0,037, p=0,026). Les autres facteurs de fragilité comme la neutropénie ou un score OMS textgreater2 n'étaient pas significativement associés à un plus fort taux d'échec. Par ailleurs, le risque d'échec du verrous ne semblait pas lié à la bactérie. Parmi les patients ayant complété leur traitement, une durée plus courte de verrou antibiotique était significativement associée à un taux de rechute plus élevé (9 vs 14 jours, p=0,033).
Conclusion
Le traitement conservateur des bactériémies liées aux CIVLD semble être efficace avec néanmoins un taux d'échec plus élevé que ceux précédemment rapportés dans la littérature. Être traité pour un cancer solide et être traité moins longtemps semble être associé à un taux d'échec plus élevé. Il serait intéressant d'inclure les infections liées aux cathéters d'hémodialyse de même que les patients d'oncohématologie qui sont pris en charge dans un autre centre hospitalier. Aucun lien d'intérêt
BibTeX:
@article{Marlat2023,
  author = {Marlat, C. and Grosjean, J. and Laffouilhere, T. Pressat and Etienne, M. and Alexandre, K. and Zeggay, A.},
  title = {Traitement conservateur des bactériémies liées aux cathéters veineux de longue-durée.},
  month = {May},
  journal = {Médecine et Maladies Infectieuses Formation},
  year = {2023},
  series = {Journées {Nationales} de l'{Infectiologie}},
  volume = {2},
  number = {2, Supplement},
  pages = {S34},
  url = {https://www.sciencedirect.com/science/article/pii/S2772743223001320},
  doi = {10.1016/j.mmifmc.2023.03.105}
}

BibTeX:
@phdthesis{Meury2023,
  author = {Meury, Pierrette},
  title = {Etat des lieux des exercices infirmiers de santé publique et en pratique avancée, en exercice avec des médecins en structures de soins de santé ambulatoires en {France} et analyse des collaborations au sein des binômes.},
  school = {Antilles},
  year = {2023},
  url = {https://www.theses.fr/s196547}
}

2022


Abstract: Background
Even if English is the leading language for international communication, it is essential to keep in mind that research runs at the local level by local teams generally communicating in their local/national language, especially in Europe among European projects.
Objective
and methods Therefore, the European Federation for Medical Informatics - Working Group on Health Informatics for Inter-regional Cooperation” has one objective: To develop a multilingual ontology focusing on Health Informatics as a collaboration tool that improves international and, in particular, European collaborations.
Results
We have developed the Medical Informatics and Digital Health Multilingual Ontology (MIMO). Hosted on the Health Terminology/Ontology Portal (HeTOP), MIMO contains around 1,000 concepts, 460 MeSH Descriptors, 220 MeSH Concepts, and more than 300 newly created concepts. MIMO is continuously updated to comprise as recent as possible concepts and their translations in more than 30 languages. Moreover, the MIMO’s development team constantly improves MIMO content and supporting information. Thus, during workshop discussions and one-on-one exchanges, the MIMO team has collected domain experts’ opinions about the community’s interests and suggestions for future enhancements. Moreover, MIMO will be integrated to support the annotation and categorization of research products into the HosmartAI European project involving more than 20 countries around Europe and worldwide.
Conclusion
MIMO is hosted by HeTOP (Health Terminology/Ontology Portal), which integrates 100 terminologies and ontologies in 55 languages. MIMO is freely available online. MIMO is portable to other knowledge platforms as part of MIMO’s main aims to facilitate communication between medical librarians, translators, and researchers as well as to support students’ self-learning.
BibTeX:
@article{Benis2022,
  author = {Benis, Arriel and Grosjean, Julien and Billey, Kevin and Gustavo Montanha Meireles Martins, Jose and Dornauer, Verena and Crisan-Vida, Mihaela and Hackl, Werner O. and Stoicu-Tivadar, Lacramioara and Darmoni, Stéfan},
  title = {Medical {Informatics} and {Digital} {Health} {Multilingual} {Ontology} ({MIMO}): a tool to improve international collaborations},
  month = {August},
  journal = {International Journal of Medical Informatics},
  year = {2022},
  pages = {104860},
  url = {https://www.sciencedirect.com/science/article/pii/S1386505622001745},
  doi = {10.1016/j.ijmedinf.2022.104860}
}

Abstract: Real-world evidence (RWE) refers to observational data gathered outside the formalism of randomized controlled trials, in real life situations, on marketed drugs. While clinical trials are the gold standards to demonstrate the efficacy and tolerability of a medicinal product, the generalizability of their results to actual use in real-life is limited by the biases induced by the very nature of clinical trials; indeed, the patients included in the trials may differ from actual users because of their concomitant diseases or treatments, or other factors excluding them from the trials. Clinical researchers and pharmaceutical industries have hence become increasingly interested in expanding and integrating RWE into clinical research, by capitalizing on the exponential growth in access to data from electronic health records, claims databases, electronic devices, software or mobile applications, registries embedded in clinical practice and social media. Meanwhile, applications of RWE may also be used for drug discovery and repurposing, for clinical developments and post-marketing studies. The aim of this review is to provide our opinion regarding the use of RWE in translational research, including non-clinical and clinical pharmacology research, at the different step of drugs development use.
BibTeX:
@article{Charveriat2022,
  author = {Charvériat, Mathieu and Darmoni, Stephan J. and Lafon, Vincent and Moore, Nicholas and Bordet, Régis and Veys, Julien and Mouthon, Franck and in Pharmacology group, S. F. P. T. Translational Research},
  title = {Use of real-world evidence in translational pharmacology research},
  month = {April},
  journal = {Fundamental \& Clinical Pharmacology},
  year = {2022},
  volume = {36},
  number = {2},
  pages = {230--236},
  doi = {10.1111/fcp.12734}
}

Abstract: INTRODUCTION: The aim of this systematic review was to assess the effectiveness of brief interventions realized in primary care in reducing cannabis use for adolescents and emerging adults.
METHODS: PubMed, CINAHL, Embase, PsycInfo, and Central (Cochrane Library) were searched until December 2020. Randomized controlled trials conducted in primary care, concerning in-person brief interventions for non-medical cannabis users aged from 12 to 25 years old were eligible for inclusion. Brief interventions had to last 30 min or less. Patients with comorbid mental health disorder or very specific populations were not included.
RESULTS: One thousand eighty hundred and fifty-five studies were identified through database searching; only 8 studies involving 2,199 patients were included for qualitative synthesis after double reading and data extraction. Randomized controlled trials selected were heterogeneous regarding screening tools, initial levels of cannabis use and cannabis outcomes measures. Brief interventions were all based on motivational interviewing techniques or personalized feedback. Seven studies consisted in a single session of brief intervention. Six studies involved also other substance users. No significant reduction of cannabis use after brief intervention was found for most studies, especially in the long term. A trend of decreased cannabis consequences, such as negative psychosocial repercussions, perception of cannabis use by peers, or driving under the influence of cannabis, was reported.
CONCLUSION: The current state of knowledge does not allow us to say that the brief intervention is effective in reducing cannabis use among adolescents in primary care. We found a mild positive effect on cannabis consequences after brief intervention. Mixed qualitative and quantitative studies are need to better evaluate the impact of brief intervention and his faisability. PROSPERO (International Prospective Register of Systematic Reviews): n° CRD42016033080.
BibTeX:
@article{Chazal2022,
  author = {Chazal, Camille and Roux, Charline and Kinouani, Shérazade and Schuers, Matthieu and Fortin, Frédéric and Pereira, Bruno and Blanc, Olivier and Piñol-Domenech, Nathalie and Brousse, Georges and Vorilhon, Philippe and Laporte, Catherine},
  title = {Effectiveness of brief interventions in primary care for cannabis users aged from 12 to 25 years old: a systematic review},
  month = {November},
  journal = {Family Practice},
  year = {2022},
  volume = {39},
  number = {6},
  pages = {1156--1168},
  doi = {10.1093/fampra/cmac050}
}

BibTeX:
@article{Dezoteux2021,
  author = {Dezoteux, F. and El Mesbahi, S. and Tedbirt, B. and Grosjean, J. and Gautier, S. and Lannoy, D. and Nassar, C. and T{\'e}tart, F. and Staumont-Sall{\'e}, D.},
  title = {Immunomodulatory and/or immunosuppressive drugs should not be stopped prior to skin tests for the assessment of drug allergy},
  month = {April},
  journal = {The British journal of dermatology},
  year = {2022},
  volume = {186},
  number = {4},
  pages = {742-744},
  doi = {10.1111/bjd.20901}
}

Abstract: Background: A major factor in the success of any search engine is the relevance of the search results; a tool should sort the search results to present the most relevant documents first. Assessing the performance of the ranking formula is an important part of search engine evaluation. However, the methods currently used to evaluate ranking formulae mainly collect quantitative data and do not gather qualitative data, which help to understand what needs to be improved to tailor the formulae to their end users.
Objective: This study aims to evaluate 2 different parameter settings of the ranking formula of LiSSa (the French acronym for scientific literature in health care; Department of Medical Informatics and Information), a tool that provides access to health scientific literature in French, to adapt the formula to the needs of the end users.
Methods: To collect quantitative and qualitative data, user tests were carried out with representative end users of LiSSa: 10 general practitioners and 10 registrars. Participants first assessed the relevance of the search results and then rated the ranking criteria used in the 2 formulae. Verbalizations were analyzed to characterize each criterion.
Results: A formula that prioritized articles representing a consensus in the field was preferred. When users assess an article’s relevance, they judge its topic, methods, and value in clinical practice.
Conclusions: Following the evaluation, several improvements were implemented to give more weight to articles that match the search topic and to downgrade articles that have less informative or scientific value for the reader. Applying a qualitative methodology generates valuable user inputs to improve the ranking formula and move toward a highly usable search engine.
BibTeX:
@article{Douze2022,
  author = {Douze, Laura and Pelayo, Sylvia and Messaadi, Nassir and Grosjean, Julien and Kerdelhué, Gaétan and Marcilly, Romaric},
  title = {Designing {Formulae} for {Ranking} {Search} {Results}: {Mixed} {Methods} {Evaluation} {Study}},
  month = {March},
  journal = {JMIR Human Factors},
  year = {2022},
  volume = {9},
  number = {1},
  pages = {e30258},
  note = {Company: JMIR Human Factors Distributor: JMIR Human Factors Institution: JMIR Human Factors Label: JMIR Human Factors Publisher: JMIR Publications Inc., Toronto, Canada},
  url = {https://humanfactors.jmir.org/2022/1/e30258},
  doi = {10.2196/30258}
}

Abstract: INTRODUCTION: Preprints have been widely cited during the COVID-19 pandemics, even in the major medical journals. However, since subsequent publication of preprint is not always mentioned in preprint repositories, some may be inappropriately cited or quoted. Our objectives were to assess the reliability of preprint citations in articles on COVID-19, to the rate of publication of preprints cited in these articles and to compare, if relevant, the content of the preprints to their published version.
METHODS: Articles published on COVID in 2020 in the BMJ, The Lancet, the JAMA and the NEJM were manually screened to identify all articles citing at least one preprint from medRxiv. We searched PubMed, Google and Google Scholar to assess if the preprint had been published in a peer-reviewed journal, and when. Published articles were screened to assess if the title, data or conclusions were identical to the preprint version.
RESULTS: Among the 205 research articles on COVID published by the four major medical journals in 2020, 60 (29.3 cited at least one medRxiv preprint. Among the 182 preprints cited, 124 were published in a peer-reviewed journal, with 51 (41.1 before the citing article was published online and 73 (58.9 later. There were differences in the title, the data or the conclusion between the preprint cited and the published version for nearly half of them. MedRxiv did not mentioned the publication for 53 (42.7 of preprints.
CONCLUSIONS: More than a quarter of preprints citations were inappropriate since preprints were in fact already published at the time of publication of the citing article, often with a different content. Authors and editors should check the accuracy of the citations and of the quotations of preprints before publishing manuscripts that cite them.
BibTeX:
@article{Gehanno2022,
  author = {Gehanno, Jean-Francois and Grosjean, Julien and Darmoni, Stefan J. and Rollin, Laetitia},
  title = {Reliability of citations of {medRxiv} preprints in articles published on {COVID}-19 in the world leading medical journals},
  journal = {PloS One},
  year = {2022},
  volume = {17},
  number = {8},
  pages = {e0264661},
  doi = {10.1371/journal.pone.0264661}
}

Abstract: INTRODUCTION: The cytochrome P450 (CYP450) enzyme system is involved in the metabolism of certain drugs and is responsible for most drug interactions. These interactions result in either an enzymatic inhibition or an enzymatic induction mechanism that has an impact on the therapeutic management of patients. Detecting these drug interactions will allow for better predictability in therapeutic response. Therefore, computerized solutions can represent a valuable help for clinicians in their tasks of detection.
OBJECTIVE: The objective of this study is to provide a structured data-source of interactions involving the CYP450 enzyme system. These interactions are aimed to be integrated in the cross-lingual multi-terminology server HeTOP (Health Terminologies and Ontologies Portal), to support the query processing of the clinical data warehouse (CDW) EDSaN (Entrepôt de Données de Santé Normand).
MATERIAL AND METHODS: A selection and curation of drug components (DCs) that share a relationship with the CYP450 system was performed from several international data sources. The DCs were linked according to the type of relationship which can be substrate, inhibitor, or inducer. These relationships were then integrated into the HeTOP server. To validate the CYP450 relationships, a semantic query was performed on the CDW, whose search engine is founded on HeTOP data (concepts, terms, and relations).
RESULTS: A total of 776 DCs are associated by a new interaction relationship, integrated in HeTOP, by 14 enzymes. These are CYP450 1A2, 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 3A4, 3A7, 11B1,11B2 mitochondrial and P-glycoprotein, constituting a total of 2,088 relationships. A general modelling of cytochromic interactions was performed. From this model, 233,006 queries were processed in less than two hours, demonstrating the usefulness and performance of our CDW implementation. Moreover, they showed that in our university hospital, the concurrent prescription that could cause a cytochromic interaction is Bisoprolol with Amiodarone by enzymatic inhibition for 2,493 patients.
DISCUSSION: The queries submitted to the CDW EDSaN allowed to highlight the most prescribed molecules simultaneously and potentially responsible for cytochromic interactions. In a second step, it would be interesting to evaluate the real clinical impact by looking for possible adverse effects of these interactions in the patients' files. Other computational solutions for cytochromic interactions exist. The impact of CYP450 is particularly important for drugs with narrow therapeutic window (NTW) as they can lead to increased toxicity or therapeutic failure. It is also important to define which drug component is a pro-drug and to considerate the many genetic polymorphisms of patients.
CONCLUSION: The HeTOP server contains a non-negligible number of relationships between drug components and CYP450 from multiple reference sources. These data allow us to query our Clinical Data Warehouse to highlight these cytochromic interactions. It would be interesting in the future to assess the actual clinical impact in hospital reports.
BibTeX:
@article{Gosselin2022,
  author = {Gosselin, Laura and Letord, Catherine and Leguillon, Romain and Soualmia, Lina F. and Dahamna, Badisse and Mouazer, Abdelmalek and Disson, Flavien and Darmoni, Stéfan J. and Grosjean, Julien},
  title = {Modeling and integrating interactions involving the {CYP450} enzyme system in a multi-terminology server: {Contribution} to information extraction from a clinical data warehouse},
  month = {December},
  journal = {International Journal of Medical Informatics},
  year = {2022},
  volume = {170},
  pages = {104976},
  doi = {10.1016/j.ijmedinf.2022.104976}
}

Abstract: BACKGROUND: Whether gastroparesis is associated with a shortened life expectancy remains uncertain as no systematic study has evaluated the impact of gastroparesis on mortality, based on gastric emptying (GE) tests.
AIM: This study aimed to assess whether delayed GE was predictive of mortality.
METHODS: GE was measured using a 13C-octanoic acid breath test in 1563 consecutive patients. Delayed GE at baseline defined the gastroparesis group. Patients were followed up for a mean of 8.9 years, yielding 13 466 patients per year. Mortality was assessed using the French CepiDc database with data from local civil registries. The cause of death was determined from medical records. Mortality rates were assessed using the Kaplan-Meier method and hazard ratio (HR) was calculated using the Cox regression model.
RESULTS: Age and symptoms severity were not different among patients with normal GE (n = 1179) and with delayed GE (n = 384) while diabetes mellitus was more frequent in the gastroparesis group. Kaplan-Meier analysis showed increased mortality in the gastroparesis group compared to patients with normal GE. Cox regression model identified delayed GE as independently associated with increased mortality (HR = 1.63[1.09-2.42]; P = 0.02). Other independent factors associated with increased mortality included age, male sex, and diabetes. No difference was observed between groups for the cause of death, with cancer and cardiovascular disease being the leading causes.
CONCLUSION: This study has shown that gastroparesis, diagnosed on GE tests, was associated with increased mortality, independently of age, sex, BMI or diabetes status (NCT04918329).
BibTeX:
@article{Gourcerol2022,
  author = {Gourcerol, Guillaume and Melchior, Chloé and Wuestenberghs, Fabien and Desprez, Charlotte and Prevost, Gaëtan and Grosjean, Julien and Leroi, Anne Marie and Tavolacci, Marie Pierre},
  title = {Delayed gastric emptying as an independent predictor of mortality in gastroparesis},
  month = {April},
  journal = {Alimentary Pharmacology \& Therapeutics},
  year = {2022},
  volume = {55},
  number = {7},
  pages = {867--875},
  doi = {10.1111/apt.16827}
}

Abstract: BACKGROUND: The diverse and complex variations in the possible forms of health-work interactions are constantly reconfigured over the course of a person's career.
OBJECTIVES: The aims of this study were: 1) assess the scope of the individual changes in working conditions; 2) examine conjoint changes in working conditions; 3) examine the links between these changes and back pain and fatigue.
METHOD: Analyses were conducted using data from the French observatory EVREST. The variations for each individual (close to 8,000 in total) were studied by comparing data for each individual obtained at two dates at least four years apart within the period between 2010 and 2017.
RESULTS: The frequency of the studied constraints was often similar at two dates (T1 and T2), but significantly higher for repetitive movements, working additional hours and interruptions which disrupt the work. The variations in physical constraints, intensity of work and lack of agency scores between the two timepoints are two-by-two positively correlated. Finally, respondents in the higher tertiles for any of these working condition scores at T2 had a higher probability of back pain or fatigue, compared to individuals in the lower tertiles at both timepoints. Being in a higher tertile at both dates corresponded to the highest odds-ratios for health complaints.
CONCLUSION: From a "sustainability" perspective, these findings support treating this diversity of seniority in a profession and past experience at the same time as major decisions on production are made, rather than dealing with it as an afterthought.
BibTeX:
@article{Leroyer2022,
  author = {Leroyer, Ariane and Mardon, Céline and Rollin, Laétitia and Volkoff, Serge},
  title = {Individual changes in working and health conditions: {A} longitudinal study of 8,000 employees between 2010 and 2017 in {France}},
  journal = {Work (Reading, Mass.)},
  year = {2022},
  volume = {73},
  number = {3},
  pages = {1023--1035},
  doi = {10.3233/WOR-210992}
}

Abstract: This multicenter study was conducted in French memory clinics during the first COVID-2019 lockdown (March-May 2020). The objective was to evaluate the effect of a telemedicine consultation on treatment modification in dementia care. Among 874 patients who had a telemedicine consultation, 103 (10.7 …
BibTeX:
@article{Morin2022,
  author = {Morin, A. and Pressat-Laffouilhere, T. and Sarazin, M. and Lagarde, J. and Roue-Jagot, C. and Olivieri, P. and Paquet, C. and Cognat, E. and Dumurgier, J. and Pasquier, F. and Lebouvier, T. and Ceccaldi, M. and Godefroy, O. and Martinaud, O. and Grosjean, J. and Zarea, A. and Maltête, D. and Wallon, D.},
  title = {Telemedicine in {French} {Memory} {Clinics} {During} the {COVID}-19 {Pandemic}},
  month = {December},
  journal = {Journal of Alzheimer's disease : JAD},
  year = {2022},
  volume = {86},
  number = {2},
  note = {Publisher: J Alzheimers Dis},
  url = {https://pubmed.ncbi.nlm.nih.gov/34974434/},
  doi = {10.3233/JAD-215459}
}

Abstract: Polypharmacy, the consuming of more than five drugs, is a public health problem. It can lead to many interactions and adverse drug reactions and is very expensive. Therapeutic guidelines for managing polypharmacy in the elderly have been issued, but are highly complex, limiting their use. Decision-support systems have therefore been developed to automate the execution of these guidelines, or to provide information about drugs adapted to the context of polypharmacy. These systems differ widely in terms of their technical design, knowledge sources and evaluation methods. We present here a scoping review of electronic systems for supporting the management, by healthcare providers, of polypharmacy in elderly patients. Most existing reviews have focused mainly on evaluation results, whereas the present review also describes the technical design of these systems and the methodologies for developing and evaluating them. A systematic bibliographic search identified 19 systems differing considerably in terms of their technical design (rule-based systems, documentary approach, mixed); outputs (textual report, alerts and/or visual approaches); and evaluations (impact on clinical practices, impact on patient outcomes, efficiency and/or user satisfaction). The evaluations performed are minimal (among all the systems identified, only one system has been evaluated according to all the criteria mentioned above) and no machine learning systems and/or conflict management systems were retrieved. This review highlights the need to develop new methodologies, combining various approaches for decision support system in polypharmacy.
BibTeX:
@article{Mouazer2022,
  author = {Mouazer, Abdelmalek and Tsopra, Rosy and Sedki, Karima and Letord, Catherine and Lamy, Jean-Baptiste},
  title = {Decision-support systems for managing polypharmacy in the elderly: {A} scoping review},
  month = {June},
  journal = {Journal of Biomedical Informatics},
  year = {2022},
  volume = {130},
  pages = {104074},
  doi = {10.1016/j.jbi.2022.104074}
}

Abstract: OBJECTIVES: To introduce the 2022 International Medical Informatics Association (IMIA) Yearbook by the editors.
METHODS: The editorial provides an introduction and overview to the 2022 IMIA Yearbook whose special topic is "Inclusive Digital Health: Addressing Equity, Literacy, and Bias for Resilient Health Systems". The special topic, survey papers, section editor synopses and some best papers are discussed. The sections' changes in the Yearbook Editorial Committee are also described.
RESULTS: As shown in the previous edition, health informatics in the context of a global pandemic has led to the development of ways to collect, standardize, disseminate and reuse data worldwide. The Corona Virus Disease 2019 (COVID-19) pandemic has demonstrated the need for timely, reliable, open, and globally available information to support decision making. It has also highlighted the need to address social inequities and disparities in access to care across communities. This edition of the Yearbook acknowledges the fact that much work has been done to study health equity in recent years in the various fields of health informatics research.
CONCLUSION: There is a strong desire to better consider disparities between populations to avoid biases being induced in Artificial Intelligence algorithms in particular. Telemedicine and m-health must be more inclusive for people with disabilities or living in isolated geographical areas.
BibTeX:
@article{Mougin2022,
  author = {Mougin, Fleur and Hollis, Kate Fultz and Soualmia, Lina F.},
  title = {Inclusive {Digital} {Health}},
  month = {August},
  journal = {Yearbook of Medical Informatics},
  year = {2022},
  volume = {31},
  number = {1},
  pages = {2--6},
  doi = {10.1055/s-0042-1742540}
}

Abstract: Acute respiratory infections (ARIs) need to be better understood and treated, as they are critical to public health, especially during crises such as the SARS-CoV2 pandemic. These are the most abundant infections in the general population and are seen primarily in primary care by general practitioners (GPs). Many different viruses are involved, according to epidemic variations. Viral co-detections account for a significant proportion of ARIs in hospital cohorts. The objective of the ECOVIR cohort was to study viral co-detections by setting up a biobank of respiratory tract samples from patients consulting their general practitioner for ARI symptoms. We report here on the course of the study: the design, the conduct, and the difficulties encountered. ECOVIR (Etude des CO-detections VIrales dans les prélèvements Respiratoires) was a prospective, multicenter cohort conducted in France during two epidemic seasons (2018-2019 and 2019-2020). We recruited GPs. Each GP investigator (GPI) saw patients weekly for examination, clinical data collection, and nasopharyngeal swabbing. Each sample was sent to the virology unit for biobanking and molecular analysis. Clinical and sociodemographic data were collected 7 days after inclusion. ECOVIR involved 36 GPIs. Patients with symptoms of an ARI were included (n = 685). The median number of inclusions was 16 patients per GPI over both seasons (IC25-75% [4.75; 27]). Patients aged 18 to 64 years were the most numerous (57, followed by children (30, and the elderly (13% over 65 years). This age distribution emphasizes the young adult and middle-aged population. Residents participated in the project and called patients on day 7 to obtain clinical and sociodemographic data. Our study triggered the creation of an original network, which plans to establish a functional link between research and primary health care. Primary care is unfortunately poorly represented in research protocols, particularly in respiratory infections, even though it is a cornerstone of our French health care system, as demonstrated every day in this period of crisis.
BibTeX:
@article{Petat2022a,
  author = {Petat, Hortense and Schuers, Matthieu and Corbet, Sandrine and Humbert, Xavier and Le Bas, François and Marguet, Christophe and Pellerin, Lucille and Rabiaza, Andry and Vabret, Astrid and Ar Gouilh, Meriadeg},
  title = {The {Design} and {Implementation} of the {ECOVIR} {Project}: {A} {Primary} {Health} {Care} {Surveillance} {System} to {Strengthen} {Co}-{Detection} of {Respiratory} {Viruses} in {Normandy}},
  month = {December},
  journal = {Methods and Protocols},
  year = {2022},
  volume = {5},
  number = {6},
  pages = {98},
  doi = {10.3390/mps5060098}
}

Abstract: Our study confirmed the diversity of NIPs, including in neighboring European countries with similar factors like economic resources and epidemiological risk, thus indicating that other factors underlie NIPs. Convergence toward a more common immunization program including MenACWY and MenB vaccination …
BibTeX:
@article{PintoCardoso2022,
  author = {Pinto Cardoso, G. and Lagrée-Chastan, M. and Caseris, M. and Gaudelus, J. and Haas, H. and Jp, Leroy and Bakhache, P. and Jf, Pujol and Werner, A. and Ma, Dommergues and Pauquet, E. and Pinquier, D.},
  title = {Overview of meningococcal epidemiology and national immunization programs in children and adolescents in 8 {Western} {European} countries},
  month = {November},
  journal = {Frontiers in pediatrics},
  year = {2022},
  volume = {10},
  note = {Publisher: Front Pediatr},
  url = {https://pubmed.ncbi.nlm.nih.gov/36507149/},
  doi = {10.3389/fped.2022.1000657}
}

Abstract: BACKGROUND: Unstructured data from electronic health records represent a wealth of information. Doc'EDS is a pre-screening tool based on textual and semantic analysis. The Doc'EDS system provides a graphic user interface to search documents in French. The aim of this study was to present the Doc'EDS tool and to provide a formal evaluation of its semantic features.
METHODS: Doc'EDS is a search tool built on top of the clinical data warehouse developed at Rouen University Hospital. This tool is a multilevel search engine combining structured and unstructured data. It also provides basic analytical features and semantic utilities. A formal evaluation was conducted to measure the impact of Natural Language Processing algorithms.
RESULTS: Approximately 18.1 million narrative documents are stored in Doc'EDS. The formal evaluation was conducted in 5000 clinical concepts that were manually collected. The F-measures of negative concepts and hypothetical concepts were respectively 0.89 and 0.57.
CONCLUSION: In this formal evaluation, we have shown that Doc'EDS is able to deal with language subtleties to enhance an advanced full text search in French health documents. The Doc'EDS tool is currently used on a daily basis to help researchers to identify patient cohorts thanks to unstructured data.
BibTeX:
@article{Pressat-Laffouilhere2020,
  author = {Pressat-Laffouilhère, Thibaut and Balayé, Pierre and Dahamna, Badisse and Lelong, Romain and Billey, Kévin and Darmoni, Stéfan J. and Grosjean, Julien},
  title = {Evaluation of {Doc}'{EDS}: a {French} semantic search tool to query health documents from a clinical data warehouse},
  month = {February},
  journal = {BMC medical informatics and decision making},
  year = {2022},
  volume = {22},
  number = {1},
  pages = {34},
  doi = {10.1186/s12911-022-01762-4}
}

Abstract: INTRODUCTION: Radical prostatectomy (RP) can generate multidimensional physiological changes, like decrease in physical and emotional functioning, as well as Health Related Quality of Life (HRQoL). However, only pelvic floor muscle training (PFMT) is commonly recommended as conservative treatment after RP. More comprehensive interventions than only PFMT, such as physiotherapy promoting general coordination, flexibility, strength, endurance, fitness and functional capacity may seem more relevant and patient-centered.
AIM OF THE REVIEW: Our aim was to evaluate whether a more Comprehensive Functional Physical Therapy (CFPT) than PFMT alone, focused on lower limb and lumbo-pelvic exercises, would improve physical capacities and functions (including urinary continence (UI)), emotional functions and HRQoL in patients after RP.
EVIDENCE ACQUISITION: A systematic review was performed in accordance with the PRISMA reporting guidelines. A literature search was conducted in PubMed, PEDro, Web of Science and Cochrane Library databases from inception to January 2022. The PICO approach was used to determine the eligibility criteria. According to the quality of selected studies, levels of evidence were given.
EVIDENCE SYNTHESIS: Eight clinical trials met the eligibility criteria. Regarding UI, all the studies reported positive outcomes for CFPT between pre- and post-physiotherapy (Ptextless0.05). The selected studies reported positive outcomes for physical capacities as well as for physical and emotional functioning, and for HRQoL (Ptextless0.05).
CONCLUSION: Current literature indicates that CFPT was shown to be safe, non-invasive, and particularly effective in terms of UI recovery. CFPT could result in more positive outcomes, including physical capacities, physical and emotional functioning and HRQoL, than PFMT alone. Further standardized, physiotherapist-guided and well-designed clinical trials conducted by experienced multidisciplinary clinicians are still called for.
BibTeX:
@article{Steenstrup2022,
  author = {Steenstrup, B. and Cartier, M. and Nouhaud, F. X. and Kerdelhue, G. and Gilliaux, M.},
  title = {A systematic review of supervised comprehensive functional physiotherapy after radical prostatectomy},
  month = {July},
  journal = {Progres En Urologie: Journal De l'Association Francaise D'urologie Et De La Societe Francaise D'urologie},
  year = {2022},
  volume = {32},
  number = {7},
  pages = {525--539},
  doi = {10.1016/j.purol.2022.04.008}
}

Abstract: Résumé
Objectifs
Déterminer les besoins du suivi médical par la médecine du travail chez les externes en médecine. Recueillir leurs perceptions par rapport à leurs études, connaître leurs points de vue et leurs connaissances sur la médecine du travail et enfin, améliorer le suivi médical des externes afin de limiter les risques psychosociaux.
Méthode
Il s’agissait d’une étude observationnelle épidémiologique analytique, de cohorte, rétrospective et monocentrique. Durant la période de février 2020 à décembre 2020, les étudiants de la 4e à la 6e année de Médecine du CHU de Rouen remplissaient un questionnaire spécifiquement créé pour l’étude comprenant le questionnaire HAD versant dépression.
Résultats
Au total, 494 étudiants sur 840 ont participé à l’étude, soit un taux de participation de 59 %. Parmi ceux-ci, le manque de reconnaissance au travail était déclaré par 94  le fait d’avoir fait des sacrifices pour continuer médecine par 85 %. Ils étaient 43 % à ne pas recommander leurs études aux lycéens et 24 % ne referaient pas médecine. L’anxiété, la fatigue chronique, la surcharge de travail et les troubles du sommeil touchaient respectivement 82  70  65 % et 41 % des étudiants et 31 % voyaient un spécialiste pour discuter de leurs études. La consommation de substance pour supporter les études était déclarée par 18 % des étudiants. Enfin, 71 % trouvaient que le suivi en médecine du travail était inadapté ou inexistant. Ils estimaient que le manque de temps et la méconnaissance du rôle de la médecine du travail limitaient le suivi.
Conclusion
Cette enquête a permis de montrer qu’il existait encore beaucoup de mal-être chez les étudiants, qu’ils étaient toujours confrontés à de nombreuses difficultés. Les risques psychosociaux, apparaissent dès le début des études médicales et il est important d’agir dès que possible. La médecine du travail est un élément important du suivi de la santé des étudiants en médecine. La visite d’embauche sera extrêmement importante dans la prise en charge des étudiants. La mise en place de séances d’informations entre les cours, de flyers ou d’affiches pour communiquer sur le rôle et les missions du service permettront une information pour les étudiants.
Summary
Background
Determine the needs for medical follow-up by occupational medicine among Medicine students. Collect their feelings about their studies, know their point of view and their knowledge about occupational medicine and finally improve the medical follow-up of externs in order to limit psycho-social risks.
Method
This was an analytical, cohort, retrospective, single-center, epidemiological observational study. Between February 2020 and September 2020, Medicine students from 4th to 6th year of the studies completed a questionnaire specifically created for the study including the HAD depression questionnaire.
Results
Among the 494 participating students, the lack of recognition at work was declared by 94 the fact of having made sacrifices to continue medicine by 85%. They were 43% not to recommend their studies to high school students and 24% would not return to medicine. Anxiety, chronic fatigue, work overload and sleep disturbances affected 82 70 65% and 41% of students, respectively, and 31% saw a specialist to discuss their studies. Substance consumption to support studies was reported by 18% of students. Finally, 71% found that occupational health follow-up was inadequate or non-existent. They felt that the lack of time and the lack of knowledge of the role of occupational medicine limited follow-up.
Conclusions
Occupational medicine is an important part of monitoring the health of medical students. The employment visit will be extremely important in the care of the students. This survey showed that there was still a lot of discomfort among students, that they still face many difficulties. The psycho-social risks appear early in medical studies and it is important to act as soon as possible. The setting up of information sessions between classes, flyers or posters to communicate on the role and missions of the service will allow students to be informed.
BibTeX:
@article{Maufroid2022,
  author = {Maufroid, V. and Boyer, A. F. and Gehanno, J. F. and Rollin, L.},
  title = {Étude sur la perception des étudiants en médecine de {Rouen} à propos de leur externat, de leur état de santé général ainsi que leurs liens avec la médecine du travail},
  month = {October},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2022},
  volume = {83},
  number = {5},
  pages = {472--482},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878522000832},
  doi = {10.1016/j.admp.2022.05.003}
}

BibTeX:
@article{Mornex2022,
  author = {Mornex, J.-F. and Balduyck, M. and Bouchecareilh, M. and Cuvelier, A. and Epaud, R. and Kerjouan, M. and Le Rouzic, O. and Pison, C. and Plantier, L. and Pujazon, M.-C. and Reynaud-Gaubert, M. and Toutain, A. and Trumbic, B. and Willemin, M.-C. and Zysman, M. and Brun, O. and Campana, M. and Chabot, F. and Chamouard, V. and Dechomet, M. and Fauve, J. and Girerd, B. and Gnakamene, C. and Lefrançois, S. and Lombard, J.-N. and Maitre, B. and Maynié-François, C. and Moerman, A. and Payancé, A. and Reix, P. and Revel, D. and Revel, M.-P. and Schuers, M. and Terrioux, P. and Theron, D. and Willersinn, F. and Cottin, V. and Mal, H.},
  title = {Atteinte pulmonaire du déficit en alpha-1 antitrypsine. {Recommandations} pratiques pour le diagnostic et la prise en charge},
  month = {July},
  journal = {Rev Mal Respir},
  year = {2022},
  pages = {S0761--8425(22)00233--9},
  doi = {10.1016/j.rmr.2022.06.002}
}

Abstract: Comprendre et traiter les infections respiratoires aiguës (IRA) sont un enjeu majeur de santé publique, particulièrement en cette période de pandémie à SARS-CoV2. ECOVIR (Étude des co-détections virales dans les prélèvements respiratoires), est une étude prospective, multicentrique, en Normandie, sur deux saisons hivernales (2018–2019 et 2019–2020). L’objectif de ce projet était de créer une biothèque de prélèvements respiratoires à partir d’une cohorte de patients consultant leur médecin traitant pour des symptômes d’IRA, permettant d’étudier les co-détections virales. Trente-six médecins généralistes investigateurs (MGI), dans 8 maisons de santé normandes, ont participé à l’étude. Au total, 685 patients ont été inclus, présentant des symptômes d’IRA, et ont bénéficié d’un prélèvement nasopharyngé au cabinet médical par les MGI pour analyse virologique. Trente et un MGI/36 ont inclus des patients. La médiane d’inclusion était de 16 patients par MGI sur les 2 saisons (IC25–75 % [4,75 ; 27]). De plus, 92 % des patients ont répondu à l’appel à j7, recueillant des données cliniques, environnementales, et sociodémographiques. Nous avons donc créé un vrai réseau, original, permettant d’assurer un lien entre la recherche et les soins primaires, peu représentés dans les protocoles de recherche mais qui sont la pierre angulaire de notre système de santé en France, comme nous le constatons actuellement avec la crise sanitaire.
BibTeX:
@article{Petat2022,
  author = {Petat, H. and Schuers, M. and Rabiaza, A. and Marguet, C. and Pellerin, L. and Le Bas, F. and Humbert, X. and Corbet, S. and Deseille, B. and Gosse, L. and Lambert, P.-A. and Poupon, T. and Vervisch, E. and Morello, R. and Chaillot, F. and Ecovir, M. and Vabret, A. and Le Gouil, M.},
  title = {{ECOVIR} : mise en place d’une cohorte en soins primaires, un exemple de coopération pluri-professionnelle ville-hôpital},
  month = {March},
  journal = {Revue Des Maladies Respiratoires},
  year = {2022},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916614/},
  doi = {10.1016/j.rmr.2022.02.060}
}

Abstract: Résumé
Introduction
Les asthmes sont la cause la plus fréquente de maladie respiratoire professionnelle dans les pays industrialisés. Les données épidémiologiques sur la prédominance d’un genre au sein de la population de travailleurs atteints d’asthme en relation avec le travail (ART) sont contradictoires, les données les plus récentes suggérant toutefois une prédominance féminine. L’objectif de notre étude est de comparer par sexe, les expositions et les secteurs d’activités au sein d’une population française de travailleurs ayant consulté pour un ART.
Méthodes
Nous avons recensé les cas d’ART (Codes J45, U05, J68 de la CIM-10) enregistrés entre 2001 et 2018 dans la base du RNV3P (Réseau national de vigilance et de prévention des pathologies professionnelles). Les paramètres étudiés étaient les données démographiques du patient, les expositions professionnelles, les postes de travail et le secteur d’activité. Seules les expositions avec une imputabilité jugée moyenne ou forte par le clinicien ont été retenues.
Résultats
Entre 2001 et 2018, 8385 cas d’ART ont été enregistrés, majoritairement chez les hommes (54,5  ; 13,5 % étaient des asthmes aux irritants. Une tendance à la diminution du nombre d’ART a été constatée sur la période. Les femmes souffrant d’ART exerçaient significativement plus dans les secteurs de la coiffure, des activités hospitalières et étaient principalement exposées aux composés d’ammonium quaternaire, aux produits d’entretien et détergents pour locaux. Les hommes étaient significativement plus représentés dans la boulangerie et le secteur du bâtiment et travaux publics (BTP), et majoritairement exposés aux poussières de farines, aux cyanates et isocyanates.
Conclusion
Notre étude confirme des différences en fonction du genre en termes d’expositions et de secteurs d’activités à l’origine d’ART. Il apparaît nécessaire de tenir compte des spécificités des ART dans les deux sexes afin d’établir rapidement le lien entre une exposition, un secteur d’activité et l’apparition ou l’aggravation d’un asthme.
Summary
Work related asthma in women: compared to data in men. Retrospect data study carried out by the RNV3P: National Network Watch and Prevention of Work related Pathologies.
Introduction
Asthma is the leading cause of work related pathologies in industrialized countries. Epidemiological data on the predominance of a certain gender among workers with asthma among workers suffering from this disease is contradictory though the most recent studies seem to indicate an added frequency among female workers. The purpose of our study is to compare by sex, exposures and sectors of activity among the French population of workers who came for work-related asthma diagnosis.
Method
We tabulated recent work-related asthma cases (J45, U05, J68 of the CIM-10) recorded between 2001 and 2018 in the RNV3P (National Network Watch and Prevention of Work-related Pathologies). The following parameters were looked at: demographic patients data, professional exposures, workstations and sector of activity. We retained only the medium to strong impacts.
Results
During the period studied, 8385 WRA cases were recorded, mainly among men (54.5, 13.5% of which due to irritants. We noticed a decrease of the number of cases over the years. Women suffering from WRA were most significantly found in the following sectors: hairdressing salons, hospital activities, mainly exposed to quaternary ammonium components and housecleaning products and detergents. Men were more significantly impacted while working in bread-making activity due to various flour dusts, and in construction with cyanate and isocyanates.
Conclusion
Our study confirms sex is a variable in term of exposure and sectors of activity when it comes to WRA. It seems necessary to take this into account in both sexes in order to rapidly link them to the outset or worsening of asthma.
BibTeX:
@article{Robin2022,
  author = {Robin, C. and Vongmany, N. and Dewitte, J. D. and Lodde, B. and Larabi, L. and Lucas, D.},
  title = {Asthmes en relation avec le travail chez la femme : comparaison aux données masculines. Étude rétrospective des données issues du {Réseau} national de vigilance et de prévention des pathologies professionnelles ({RNV3P})},
  month = {June},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2022},
  volume = {83},
  number = {3},
  pages = {181--192},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878522000364},
  doi = {10.1016/j.admp.2022.01.013}
}

Abstract: OBJECTIVES: To describe psychosocial constraints and mental health of hospital workers, and to identify the psychosocial constraints significantly associated with mental health difficulties, especially in two groups: caregivers and other hospital workers.
METHOD: Data about working conditions and health status collected by the Evrest National observatory in 2018-2019 during occupational health consultation were used. Psychosocial constraints and mental health among caregivers, other hospital workers and non-hospital workers were described.
RESULTS: There were 1251 hospital workers (843 caregivers, 408 other hospital workers) and 25 129 other workers. Intensity and working time (time pressure, extra working time, missing or shortening a meal), and ethical dilemmas (not having the means to ensure high-quality work, too rapidly handling a procedure that would require more painstaking care) were significantly more reported by the caregivers than by the other hospital workers (50.8% vs 44.2 43.4% vs 32.5 47.2% vs 17.2 21.4% vs 16.4% and 41.5% vs 29.0% respectively). Prevalence of psychological distress was not significantly higher for caregivers (12.3 than for other hospital workers (12.4 but was significantly higher than for other workers (7.3. For caregivers, factors significantly associated with psychological distress were time pressure (Odds Ratio adjusted on sociodemographic factors (OR) = 2.33 CI95% [1.35-4.04]), "difficulties to reconcile private life and work life" (OR = 2.95 [1.54-5.69]), "work not recognized in the professional setting" (OR = 1.89 [1.08-3.31]) and "fear of losing one's job" (OR = 2.98 [1.53-5.8]). For other hospital workers, they were "difficulties to reconcile private life and work life (OR = 2.76 [1.04-7.30]), "insufficient possibilities of mutual aid" (OR = 2.85 [1.24-6.53] and "not having the means to ensure high-quality work" (OR = 3.42 [1.62-7.21]).
CONCLUSION: Factors significantly associated with psychological distress were not the same for caregivers and other hospital workers, nor were they the most frequently reported. Detailed description of the constraints according to group of workers could help to develop a high-priority preventive program regarding psychosocial risk factors.
BibTeX:
@article{Rollin2022,
  author = {Rollin, Laetitia and Gehanno, Jean-François and Leroyer, Ariane},
  title = {Occupational stressors in healthcare workers in {France}},
  month = {March},
  journal = {Revue D'epidemiologie Et De Sante Publique},
  year = {2022},
  pages = {S0398--7620(22)00160--2},
  doi = {10.1016/j.respe.2022.02.002}
}

Abstract: Objectif
L’objectif de cette revue était de préciser l’association potentielle entre l’évolution des courbures vertébrales liées à l’âge et le risque de prolapsus des organes pelviens chez les femmes.
Méthode
Une revue systématique PRISMA a été effectuée. Les mots clés ont été choisis en accord avec les critères d’éligibilité PICO. Pour être incluses, les études devaient être des cohortes observationnelles, des études de cas témoins ou des études transversales. La qualité des articles a été évaluée à l’aide de l’échelle STROBE.
Résultats
Cinq articles de 1996 à 2021 ont été inclus dans la présente revue avec des résultats conflictuels. Quatre études ont rapporté une association positive entre les prolapsus anatomiques à l’examen clinique, une diminution de la lordose lombaire et une augmentation de la cyphose thoracique. L’étude restante, basée sur l’évaluation des symptômes par questionnaire, n’a trouvé aucune association entre les symptômes liés aux prolapsus des organes pelviens et les modifications des courbures de la colonne vertébrale liées à l’âge.
Conclusion
D’après les données disponibles, cette revue suggère une preuve très modérée d’association entre le développement de prolapsus des organes pelviens anatomique et les modifications de courbures sagittales vertébrales liées à l’âge chez la femme. Cette revue reste limitée par le faible nombre et l’hétérogénéité des études incluses. Des études complémentaires, si possible longitudinales, avec des protocoles de bonne qualité méthodologique, devraient être menées pour une meilleure compréhension de la physiopathologie des prolapsus des organes pelviens.
BibTeX:
@article{Steenstrup2022a,
  author = {Steenstrup, B. and Cornu, J. N. and Poilvet, E. and Breard, H. and Kerdelhue, G. and Gilliaux, M.},
  title = {Impact des modifications des courbures vertébrales sagittales liées à l’âge sur les prolapsus des organes pelviens. {Une} revue systématique de la littérature},
  month = {July},
  journal = {Progres En Urologie: Journal De l'Association Francaise D'urologie Et De La Societe Francaise D'urologie},
  year = {2022},
  volume = {32},
  number = {7},
  pages = {516--524},
  doi = {10.1016/j.purol.2022.02.003}
}

Abstract: Résumé
Introduction
Les expositions professionnelles des chauffeurs de bus urbain et leurs conséquences sur la santé restent mal caractérisées et l’imputabilité de certaines pathologies est parfois plus difficile à établir que pour d’autres catégories de conducteurs de véhicules lourds. L’objectif de cette étude était de décrire les expositions professionnelles et d’état de santé des chauffeurs de bus urbains en les comparant à d’autres catégories de conducteurs de véhicules lourds.
Méthodes
Une étude épidémiologique descriptive à partir des données des enquêtes Evrest (n=2494), Sumer 2010 (n=566) et Sumer 2017 (n=387) a permis de comparer les expositions professionnelles et la santé de différentes catégories de conducteurs de véhicules lourds (bus urbain, bus interurbain, fret interurbain et frets urbain).
Résultats
Une prévalence supérieure d’atteintes du rachis cervical ainsi que de troubles d’ordre psychologique est mise en évidence chez les chauffeurs de bus urbains comparativement aux trois autres métiers de la conduite étudiés. Aucune différence n’est retrouvée en termes de prévalence des lombalgies avec les chauffeurs poids lourds qui peuvent bénéficier d’une reconnaissance en maladie professionnelle des radiculalgies sur hernies discales lombaires. Le métier de chauffeur de bus urbains offre une faible latitude décisionnelle ainsi qu’une pression psychologique importante en lien avec les impératifs horaires et le contact avec le public. Ces constatations pourraient expliquer les atteintes à l’état de santé des chauffeurs de bus urbains retrouvées dans cette étude.
Discussion
Il est nécessaire d’approfondir nos connaissances sur les expositions professionnelles des chauffeurs de bus urbains par la réalisation d’études ciblées afin d’identifier les facteurs de risque d’altération de la santé et d’améliorer la prévention.
Summary
Introduction
The occupational exposure of urban bus drivers and their consequences on health remain poorly studied and the imputability of occupational pathologies is sometimes more difficult to establish than for other categories of heavy vehicle drivers. The aim of this study was to describe the occupational exposure and health status of urban bus drivers by comparing them to other categories of heavy vehicle drivers.
Methods
A descriptive epidemiological study using data from the EVREST (n=2494), Sumer 2010 (n=566) and Sumer 2017 (n=387) surveys compared the occupational exposure and health of different categories of heavy vehicle drivers (urban bus, intercity bus, intercity freight and urban freight).
Results
A higher prevalence of cervical spine disorders and psychological disorders was found among urban bus drivers compared to the other three driving occupations studied. No difference was found in terms of prevalence of low back pain with truck drivers, who can benefit from compensation of lumbar radiculopathy due to disc herniation as an occupational disease. Urban bus driver activity offers low decisional latitude combined with significant psychological demand due to the time constraints and contact with the public. These findings could explain the prevalence of health impairment among urban bus drivers identified in this study.
Discussion
There is a need to improve knowledge of the occupational exposure of urban bus drivers through specific studies to identify risk factors for health impairment and to improve prevention.
BibTeX:
@article{Wei2022,
  author = {Wei, K. and Fort, E. and Rollin, L. and Leroyer, A. and Charbotel, B.},
  title = {Expositions professionnelles et santé des conducteurs professionnels, quelles spécificités pour les chauffeurs de bus urbains ?},
  month = {October},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2022},
  volume = {83},
  number = {5},
  pages = {458--471},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878522000467},
  doi = {10.1016/j.admp.2022.03.001}
}

Abstract: The purpose of this study was to evaluate the reliability and reproducibility of a novel approach for base and neck fractures of the mandible. An anatomical study was conducted on 22 given to Science subjects. A rhytidectomy-like approach was performed, followed by a transmasseteric anteroparotid dissection. Measures were taken of the incision length and bone exposure at every step. The identification of a ramus of the facial nerve during dissection was noted. The subjects were classified according to their facial adiposity. A correlation coefficient was measured between incision length and bone exposure as well as morphotype and bone exposure. Statistical analysis was carried out using the Pearson method for linear correlation, and Chi2 test for further analysis. Adequate condylar exposure was always achieved in the area of interest (i.e. in the main localization of base and neck fractures). There was no correlation between the length of the cranial cutaneous backcut and the bone exposure horizontally (p = 0.3296) or vertically (p = 0.8382). There was no correlation between the total length of the incision and the bone exposure horizontally (p = 0.5171) or vertically (p = 0.8404). There was a significant correlation between the subjects' facial adiposity and the bone exposure horizontally and vertically (ptextless0.005). This approach allowed adequate bone exposure to the mandible base and neck, with a possible 90° angulation of instruments for optimal bone fixation. The incidence of facial nerve rami identification during dissection was similar to other approaches. The scarring was hidden. These results allowed us to propose this approach in a clinical study.
BibTeX:
@article{BenSlama2022,
  author = {Ben Slama, Neil and Crampon, Frederic and Maquet, Charles and Derombise, Baptiste and Duparc, Fabrice and Trost, Olivier},
  title = {Preauricular anteroparotid transmasseteric approach of the mandibular condyle: {The} natural evolution after cervical dissections? {An} anatomical feasibility study},
  month = {October},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2022},
  volume = {123},
  number = {5},
  pages = {e598--e603},
  doi = {10.1016/j.jormas.2022.05.006}
}

Abstract: A large number of Electronic Medical Records (EMR) are currently available with a variety of features and architectures. Existing studies and frameworks presented some solutions to overcome the problem of specification and application of clinical guidelines toward the automation of their use at the point of care. However, they could not yet support thoroughly the dynamic use of medical knowledge in EMRs according to the clinical contexts and provide local application of international recommendations. This study presents the development of the Clinical Knowledge Platform (CKP): a collaborative interoperable environment to create, use, and share sets of information elements that we entitled Clinical Use Contexts (CUCs). A CUC could include medical forms, patient dashboards, and order sets that are usable in various EMRs. For this purpose, we have identified and developed three basic requirements: an interoperable, inter-mapped dictionary of concepts leaning on standard terminologies, the possibility to define relevant clinical contexts, and an interface for collaborative content production via communities of professionals. Community members work together to create and/or modify, CUCs based on different clinical contexts. These CUCs will then be uploaded to be used in clinical applications in various EMRs. With this method, each CUC is, on the one hand, specific to a clinical context and on the other hand, could be adapted to the local practice conditions and constraints. Once a CUC has been developed, it could be shared with other potential users that can consume it directly or modify it according to their needs.
BibTeX:
@article{Dahlweid2022,
  author = {Dahlweid, Michael and Rausch, Dennis and Hinske, Christian and Darmoni, Stefan and Grosjean, Julien and Santi, Jonni and Marin, Lise and Yasini, Mobin},
  title = {Clinical {Knowledge} {Platform} ({CKP}): {A} {Collaborative} {Ecosystem} to {Share} {Interoperable} {Clinical} {Forms}, {Viewers}, and {Order} {Sets} with {Various} {EMRs}},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {298},
  pages = {117--121},
  doi = {10.3233/SHTI220919}
}

Abstract: The aim of this paper is to present the use of Medical Informatics Multilingual Ontology (MIMO) to index digital health resources that are (and will be) included in SaNuRN (project to teach digital health). MIMO currently contains 1,379 concepts and is integrated into HeTOP, which is a cross-lingual multiterminogy server. Existing teaching resources have been reindexed with MIMO concepts and integrated into a dedicated website. A total of 345 resources have been indexed with MIMO concepts and are freely available at https://doccismef.chu-rouen.fr/dc/env=sanurn. The development of a multilingual MIMO for enhancing the quality and the efficiency of international projects is challenging. A specific semantic search engine has been deployed to give access to digital health teaching resources.
BibTeX:
@article{Darmoni2022,
  author = {Darmoni, Stéfan and Benis, Arriel and Lejeune, Emeline and Disson, Flavien and Dahamna, Badisse and Weber, Patrick and Staccini, Pascal and Grosjean, Julien},
  title = {Digital {Health} {Multilingual} {Ontology} to {Index} {Teaching} {Resources}},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {298},
  pages = {19--23},
  doi = {10.3233/SHTI220900}
}

Abstract: The ReMIAMes project proposes a methodological framework to provide a reliable and reproducible measurement of the frequency of drug-drug interactions (DDI) when performed on real-world data. This framework relies on (i) a fine-grained and contextualized definition of DDIs, (ii) a shared minimum information model to select the appropriate data for the correct interpretation of potential DDIs, (iii) an ontology-based inference module able to handle missing data to classify prescription lines with potential DDIs, (iv) a report generator giving the value of the measurement and explanations when potential false positive are detected due to a lack of available data. All the tools developed are intended to be publicly shared under open license.
BibTeX:
@article{Duclos2022,
  author = {Duclos, Catherine and Griffon, Nicolas and Daniel, Christel and Bouzillé, Guillaume and Delamarre, Denis and Darmoni, Stefan and Toubiana, Laurent and Grosjean, Julien},
  title = {Reliability of {Drug}-{Drug} {Interaction} {Measurement} on {Real}-{Word} {Data}: {The} {ReMIAMes} {Project}},
  month = {May},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {294},
  pages = {151--152},
  doi = {10.3233/SHTI220425}
}

Abstract: OBJECTIVE: The aim of this paper is to propose an extended translation of the MeSH thesaurus based on Wikipedia pages.
METHODS: A mapping was realized between each MeSH descriptor (preferred terms and synonyms) and corresponding Wikipedia pages.
RESULTS: A tool called "WikiMeSH" has been developed. Among the top 20 languages of this study, seven have currently no MeSH translations: Arabic, Catalan, Farsi (Iran), Mandarin Chinese, Korean, Serbian, and Ukrainian. For these seven languages, WikiMeSH is proposing a translation for 47% for Arabic to 34% for Serbian.
CONCLUSION: WikiMeSH is an interesting tool to translate the MeSH thesaurus and other health terminologies and ontologies based on a mapping to Wikipedia pages.
BibTeX:
@article{Dusenne2022,
  author = {Dusenne, Mikaël and Billey, Kévin and Desgrippes, Florent and Benis, Arriel and Darmoni, Stéfan Jacques and Grosjean, Julien},
  title = {{WikiMeSH}: {Multi} {Lingual} {MeSH} {Translations} via {Wikipedia}},
  month = {May},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {294},
  pages = {403--404},
  doi = {10.3233/SHTI220483}
}

Abstract: Clinical Data Warehouses (CDW) are gold mines and may be useful to manage the COVID-19 outbreak. This article details the use of CDW in order to retrieve patients for vaccination purposes. A list of 34 diseases (or conditions) was published by French Health Authorities to target individuals at a high risk of developing a severe form of COVID. Using a multilevel search engine, 23 queries were built based on structured or unstructured data using natural language processing features. The Diagnosis Related Group coding system was used alone in three queries (13.0, coupled with unstructured data in four queries (17.4, and unstructured data were used alone in 16 queries (69.6. Eleven diseases (conditions) were too broad to be translated into queries. Finally, 6,006 unique re-identified patients were retrieved. This use case demonstrates the usefulness of the Rouen University Hospital CDW in retrieving patients for other purposes than translational research.
BibTeX:
@article{Grosjean2021,
  author = {Grosjean, Julien and Pressat-Laffouilhère, Thibaut and Ndangang, Marie and Leroy, Jean-Philippe and Darmoni, Stéfan J.},
  title = {Using {Clinical} {Data} {Warehouse} to {Optimize} the {Vaccination} {Strategy} {Against} {COVID}-19: {A} {Use} {Case} in {France}},
  month = {June},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {290},
  pages = {150--153},
  doi = {10.3233/SHTI220050}
}

Abstract: INTRODUCTION: The management of patients with inherited bleeding disorders in oral surgery requires the systematic evaluation of bleeding risk and the setting up of an adequate treatment protocol by the referring haematologist, defining a replacement therapy and a recommended length of hospital stay. The purpose of this study was to determine the bleeding risk associated with oral surgery for each type of inherited bleeding disorder and to evaluate the efficacy of the treatment protocols set up in our tertiary care center.
MATERIALS AND METHODS: We included all patients with an inherited bleeding disorder, managed in our oral and maxillofacial surgery department with a treatment protocol set up by our local Haemophilia Treatment Centre for an oral surgical procedure.
RESULTS: Between January 2006 and December 2018, 295 treatment protocols were set up for the management of patients with haemorrhagic risk in oral surgical procedures. Of these, 203 were scheduled to take place in our department. A total of 180 oral surgical procedures for 147 patients were included. The incidence of bleeding complications in our study was 4.44% (8 out of 180) with a significantly higher risk in patients with haemophilia, the mean time to onset of bleeding was 11 days.
DISCUSSION: The use of a treatment protocol for the management of patients with inherited bleeding disorders in oral surgery seems effective. Our rate of bleeding complications was comparable to data in the literature, and often lower.
BibTeX:
@article{Landart2022b,
  author = {Landart, Cécile and Barbay, Virginie and Chamouni, Pierre and Trost, Olivier},
  title = {Management of patients with inherited bleeding disorders in oral surgery: {A} 13-year experience},
  month = {October},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2022},
  volume = {123},
  number = {5},
  pages = {e405--e410},
  doi = {10.1016/j.jormas.2022.02.003}
}

Abstract: The frequency of potential drug-drug interactions (DDI) in published studies on real world data considerably varies due to the methodological framework. Contextualization of DDI has a proven effect in limiting false positives. In this paper, we experimented with the application of various DDIs contexts elements to see their impact on the frequency of potential DDIs measured on the same set of prescription data collected in EDSaN, the clinical data warehouse of Rouen University Hospital. Depending on the context applied, the frequency of daily prescriptions with potential DDI ranged from 0.89% to 3.90%. Substance-level analysis accounted for 48% of false positives because it did not account for some drug-related attributes. Consideration of the patient's context could eliminate up to an additional 29% of false positives.
BibTeX:
@inproceedings{Lelong2022,
  author = {Lelong, Romain and Dahamna, Badisse and Berthelot, Hélène and Duville, Willy and Letord, Catherine and Grosjean, Julien and Duclos, Catherine},
  title = {When {Context} {Matters} for {Credible} {Measurement} of {Drug}-{Drug} {Interactions} {Based} on {Real}-{World} {Data}},
  booktitle = {Challenges of Trustable AI and Added-Value on Health (MIE2022)},
  month = {May},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {294},
  pages = {38--42},
  doi = {10.3233/SHTI220392}
}

Abstract: The Normandy health data warehouse EDSaN integrates the medication orders from the University Hospital of Rouen (France). This study aims at describing the design and the evaluation of an information retrieval system founded on a complex and semantically augmented knowledge graph dedicated to EDSaN drugs' prescriptions. The system is intended to help the selection of drugs in the search process by health professionals. The manual evaluation of the relevance of the returned drugs showed encouraging results as expected. A deeper analysis in order to improve the ranking method is needed and will be performed in a future work.
BibTeX:
@inproceedings{Lelong2021,
  author = {Lelong, Romain and Dahamna, Badisse and Leguillon, Romain and Grosjean, Julien and Letord, Catherine and Darmoni, Stéfan J. and Soualmia, Lina F.},
  title = {Assisting {Data} {Retrieval} with a {Drug} {Knowledge} {Graph}},
  month = {January},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {289},
  pages = {260--263},
  url = {https://www.cismef.org/cismef/wp/wp-content/uploads/2021/10/presentation.pdf},
  doi = {10.3233/SHTI210909}
}

Abstract: Teleconsultation has become a new means of using care which has taken off significantly since the COVID crisis, The pooling of the technological environment within the TC makes it possible to set up practice reviews by reusing the data collected. Our aim was to evaluate the relevance of antibiotic therapy during teleconsultations carried out on the national teleconsultation platform "Qare" in 4 common infections. 143,428 TCs with structured prescriptions were analyzed, with an appropriate prescription in more than 82% of cases, higher than in the literature. The use of data makes it possible to quickly assess practices and inform doctors to improve their practices.
BibTeX:
@article{Melot2022,
  author = {Melot, B. and Amsilli, M. and Drouet, F. and Rodriguez, L. and Salomon, J. and Grosjean, J. and Duclos, C.},
  title = {Appropriateness of {Antibiotic} {Prescription} {During} {Teleconsultation}},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {298},
  pages = {142--146},
  doi = {10.3233/SHTI220924}
}

Abstract: Polypharmacy in elderly is a public health problem with both clinical (increase of adverse drug events) and economic issues. One solution is medication review, a structured assessment of patients' drug orders by the pharmacist for optimizing the therapy. However, this task is tedious, cognitively complex and error-prone, and only a few clinical decision support systems have been proposed for supporting it. Existing systems are either rule-based systems implementing guidelines, or documentary systems presenting drug knowledge. In this paper, we present the ABiMed research project, and, through literature reviews and brainstorming, we identified five candidate innovations for a decision support system for medication review: patient data transfer from GP to pharmacists, use of semantic technologies, association of rule-based and documentary approaches, use of machine learning, and a two-way discussion between pharmacist and GP after the medication review.
BibTeX:
@inproceedings{mouazer:hal-03479318,
  author = {Mouazer, Abdelmalek and Leguillon, Romain and Leroy, Bertille and Sedki, Karima and Simon, Christian and Falcoff, Hector and Schuers, Matthieu and Dubois, Sophie and Bousquet, Cédric and Soualmia, Lina and Letord, Catherine and Darmoni, Stéfan and Bouaud, Jacques and Séroussi, Brigitte and Tsopra, Rosy and Lamy, Jean-Baptiste},
  title = {{ABiMed}: {Towards} an {Innovative} {Clinical} {Decision} {Support} {System} for {Medication} {Reviews} and {Polypharmacy} {Management}},
  month = {January},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {289},
  pages = {61--64},
  url = {https://hal.archives-ouvertes.fr/hal-03479318},
  doi = {10.3233/SHTI210859}
}

Abstract: Suitable causal inference in biostatistics can be best achieved by knowledge representation thanks to causal diagrams or directed acyclic graphs. However, necessary and sufficient causes are not easily represented. Since existing ontologies do not fill this gap, we designed OntoBioStat in order to enable covariate selection support based on causal relation representations. OntoBioStat automatic ontological causal diagram construction and inferences are detailed in this study. OntoBioStat inferences are allowed by Semantic Web Rule Language rules and axioms. First, statements made by the users include outcome, exposure, covariate, and causal relation specification. Then, reasoning enable automatic construction using generic instances of MetaVariable and NecessaryVariable classes. Finally, inferred classes highlighted potential bias such as confounder-like. Ontological causal diagram built with OntoBioStat was compared to a standard causal diagram (without OntoBioStat) in a theoretical study. It was found that confounding and bias were not completely identified by the standard causal diagram, and erroneous covariate sets were provided. Further research is needed in order to make OntoBioStat more usable.
BibTeX:
@article{PressatLaffouilhere2022,
  author = {Pressat Laffouilhère, Thibaut and Grosjean, Julien and Bénichou, Jacques and Darmoni, Stefan J. and Soualmia, Lina F.},
  title = {{OntoBioStat}: {Supporting} {Causal} {Diagram} {Design} and {Analysis}},
  month = {May},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {294},
  pages = {302--306},
  doi = {10.3233/SHTI220463}
}

Abstract: Understanding statistical results is crucial in order to spread right conclusions. In observational studies, statistical results are often reported as associations without going further. However, each association comes from causal relations. Causal diagrams are visual representations enabling to understand causal mechanisms behind the association found. In the era of big data and growing number of variables, visual approaches become inefficient. Ontological representation of causality and reasoning could help to explain statistical results. OntoBioStat is a domain ontology related to covariate selection and bias for biostatistician users. It was designed using expert corpus from comprehensive literature review, and validated by three biostatisticians accustomed to causal diagrams. In this paper, we focused on the presentation of an OntoBioStat’s feature able to infer explanations about statistical associations. The ontologization of the feature of interest resulted in 14 object properties, three classes and five Semantic Web Rule Language rules. Each rule allows to infer a different object-property that explains statistical association between two variables. Rules are based on isCauseof statements between different individuals. OntoBioStat feature performances were illustrated through a real-life retrospective observational study. From 28 instances and 48 object properties stated, a set of 1,939 object properties were inferred. OntoBioStat explained 65% of the 48 statistical associations found. In conclusion, OntoBioStat could help to explain a part of the significant statistical associations between two variables but cannot yet predict significant ones.
BibTeX:
@inproceedings{Pressat-Laffouilhere2022,
  author = {Pressat Laffouilhère, Thibaut and Grosjean, Julien and Pinson, Jean and Darmoni, Stéfan J. and Leveque, Emilie and Lanoy, Emilie and Bénichou, Jacques and Soualmia, Lina F.},
  title = {Ontological {Representation} of {Causal} {Relations} for a {Deep} {Understanding} of {Associations} {Between} {Variables} in {Epidemiology}},
  booktitle = {Artificial {Intelligence} in {Medicine}},
  address = {Cham},
  publisher = {Springer International Publishing},
  year = {2022},
  series = {Lecture {Notes} in {Computer} {Science}},
  pages = {47--56},
  doi = {10.1007/978-3-031-09342-5_5}
}

Abstract: BACKGROUND: Although the drug is finished, identifiable, there is no universally accepted standard for naming them. The objective of this work is to evaluate qualitatively the HeTOP drug terminology server by two categories of students: (a) pharmacy students and (b) a control group.
METHODS: A formal evaluation was built to measure the perception of users about the HeTOP drug server, using the three mains questions about "teaching interest", "skill interest" (or competence) and "ergonomics".
RESULTS: The three pharmacy student subgroups gave the best and the worst score to the same categories.
CONCLUSION: All three criteria are rated above 6.5 out of 10. The HeTOP drug terminology server is freely available to "non drug" specialists (URL: www.hetop.eu/hetop/drugs/).
BibTeX:
@inproceedings{Zana2022,
  author = {Zana, Ilan and Grosjean, Julien and Letord, Catherine and Charlet, Jean and Rio, Julien and Darmoni, Elaï T. N. and Duclos, Catherine and Darmoni, Stéfan J.},
  title = {Qualitative {Evaluation} of a {Drug} {Terminology} {Server}},
  booktitle = {MEDINFO 2021: One World, One Health – Global Partnership for Digital Innovation},
  month = {June},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {290},
  pages = {1002--1003},
  doi = {10.3233/SHTI220238}
}

Abstract: Introduction
L’enthésite est une atteinte caractéristique des spondyloarthrites souvent réfractaire aux traitements usuels locaux (physiothérapie, infiltrations, ondes de choc radiales (ODC)) et systémiques (AINS, DMARDs synthétiques et biologiques). Les options thérapeutiques des enthésites rebelles sont limitées [1]. Dans ce cadre, le traitement par laser C02 pourrait avoir un intérêt. L’objectif était l’évaluation de l’efficacité et de la tolérance d’un protocole laser C02 dans le cadre d’enthésites rebelles aux traitements usuels évoluant dans le cadre d’une spondyloarthrite (SpA) ou d’un rhumatisme psoriasique (RP).
Patients et méthodes
Cette étude monocentrique menée en soins courants avec suivi standardisé a inclus tous les patients âgés de 18 ans ou plus, atteints de SpA ou RP répondant respectivement aux critères ASAS et CASPAR et présentant des enthésites rebelles à plusieurs traitements systémiques et locauxcomme définis précédemment). Les enthésites devaient avoir été authentifiées par IRM (œdème osseux adjacent à l’insertion d’un tendon) et/ou échographie (remaniement/érosion de l’enthèse à l’échographie, doppler textless 4mm de l’enthèse, présence d’une bursite). Chaque patient a bénéficié d’un protocole laser C02 de 8 séances. Il a été recueilli de façon standardisée à la première séance (S1), 8e séance (S8) et un mois après la fin du protocole (M1) la présence/absence de réveils nocturnes (RN), la présence ou non d’un dérouillage matinal (DM), l’EVA douleur au repos, l’EVA douleur à l’effort, le BASDAI avec focus sur l’item 4 (enthésites) et le pourcentage d’amélioration déclaré par le patient avec différents seuils : très satisfait (amélioration de 80 , satisfait (amélioration comprise entre 50 et 79 , modérément satisfait (amélioration entre 30 et 49 , insatisfait (textless 30 . Le recueil a été effectué à l’aide de l’EDSaN, l’Entrepôt de données de santé du CHU de Rouen [2].
Résultats
Cinq patients (2 SpA et 3 RP) ont bénéficié d’un protocole laser C02 pour des enthésites rebelles aux traitements usuels. Les localisations traitées étaient le moyen glutéal (3 patients) et le tendon d’achille (2 patients). Deux patients étaient sous DMARDs synthétiques (méthotrexate et léflunomide), un sous anti-IL17, un autre sous anti-TNFa et le dernier sous AINS seuls. Tous ont bénéficié de kinésithérapie ± ODC. Trois patients ont eu des infiltrations préalables. La durée d’évolution moyenne des symptômes était de 25 mois. Quatre patients sur cinq présentaient un DM et des RN en lien avec le site de l’enthésite à S1 et S8. Le DM et les RN ont disparu chez 2 patients à M1. La moyenne des BASDAI a diminué au cours du protocole passant de 5,1 à S1 à 3,34 à M1. La moyenne de l’item 4 du BASDAI a également diminué passant de 8 à S1, à 4,2 à S8 et 4 à M1. La moyenne des EVA douleur repos n’a pas significativement changé durant le protocole (entre 1 et 2/10). Celle des EVA douleur effort a nettement diminué passant de 7,5 à S1, à 2,6 à S8 et 3,2 à M1. Enfin, 4 patients sur 5 ont déclaré une amélioration au cours du protocole avec 3 patients très satisfaits, un patient satisfait, et le dernier insatisfait. Un seul patient n’a pas présenté du tout d’amélioration de la symptomatologie. Ceci peut s’expliquer par l’existence d’une fissure du tendon d’Achille visualisée à l’IRM et à l’échographie. Il n’a pas été observé d’effet indésirable imputable au protocole laser chez les 5 patients.
Conclusion
Dans cette série de 5 cas, le laser C02 paraît une option prometteuse dans le traitement des enthésites réfractaires dans le cadre des SpA avec ou sans psoriasis.
BibTeX:
@article{Brevet2022,
  author = {Brevet, P. and Roudesli, M. and Protat, P. and Patenere, C. and Michaud, J. and Grosjean, J. and Lequerré, T. and Vittecoq, O.},
  title = {Enthésites résistantes dans la spondyloarthrite et le rhumatisme psoriasique traitées par laser {C02} : résultats d’une étude pilote},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2022},
  series = {35e {Congrès} {Français} de {Rhumatologie}},
  volume = {89},
  pages = {A158--A159},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833022004367},
  doi = {10.1016/j.rhum.2022.10.236}
}

Abstract: Introduction
Les spondylodiscites infectieuses (SPI) sont des infections du disque intervertébral et des vertèbres adjacentes potentiellement sévères, en particulier du fait d’un risque de complications neurologiques déficitaires survenant dans environ 9,2 % selon l’étude SPONDIMMO [1]. Seules deux études françaises ont étudié les facteurs de risque d’atteinte déficitaire qui sont : la présence d’un abcès épidural, une atteinte cervicale ou thoracique, une CRPtextgreater150mg/L et une SPI à S. aureus [2]. L’objectif de cette étude monocentrique, rétrospective, était de décrire les caractéristiques des patients présentant une SPI déficitaire et de déterminer les facteurs associés à la survenue d’un tel déficit.
Patients et méthodes
À l’aide de l’entrepôt de données de santé, ont été recueillies toutes les suspicions de spondylodiscite hospitalisées dans un service de médecine ou de chirurgie de 2010 à 2020. Après révision des dossiers et exclusion des diagnostics différentiels, les patients déficitaires (présentant des troubles sphinctériens ou un déficit moteurtextless4/5) ont été comparés avec le reste de la cohorte. L’analyse statistique a été faite par test exact de Fisher pour les données qualitatives et par test de Mann-Whitney pour les données quantitatives. Les variables significativement différentes en analyse univariée ont ensuite été intégrées dans un modèle de régression logistique pour analyse multivariée.
Résultats
Après analyse de 821 dossiers, 329 patients ont été inclus. L’âge moyen était de 67,2 ans, il y avait 61,1 % d’hommes. L’atteinte rachidienne était lombaire pour 238 patients (72,3  et multifocale pour 59 (17,9 . Les bactéries causales étaient : Staphylococcus sp. pour 127 (38,6  patients Streptococcus ou Enterococcus sp. pour 88 (26,7 , bacille gram négatif (BGN) pour 45 (13,7  et mycobactérie pour 14 (4,3 . Quarante-neuf (14,9  patients présentaient une atteinte neurologique sévère dans cette cohorte, 26 étaient déficitaires d’emblée, tandis que 23 le sont devenu en cours d’hospitalisation. Après analyse multivariée, les variables associées à un déficit neurologique étaient : une infection à mycobactérie (OR 8,7 [2,2–34,4]), une infection à BGN (OR 3,0 [1,2–7,3]) la présence d’une épidurite (OR 5,4 [2,5–11,8]), une atteinte cervicale ou dorsale (OR 2,1 [1,0–4,4]) et une CRPtextgreater50mg/L (OR 5,4 [1,1–26,7]). La découverte de la SPI dans un contexte de sepsis pré-existant était associée à l’absence de déficit OR (0,3 [0,1–0,8]). L’analyse des variables associées à la survenue d’un déficit neurologique au cours de l’hospitalisation était : une infection à mycobactérie (OR 11,0 [2,6–45,5]), une infection à BGN (OR 3,2 [1,1–9,7]) et la présence d’une épidurite à l’imagerie (OR 3,8 [1,4–10,5]). Vingt (40  patients ont été traités par décompression chirurgicale avec une récupération motrice pour 13 (65 , 29 (60  ont été traités médicalement avec une récupération motrice pour 18 (62 .
Conclusion
Il s’agit, à notre connaissance, de la première étude identifiant les SPI à mycobactérie et BGN comme à risque significatif d’atteinte neurologique sévère.
BibTeX:
@article{Desvaux2022,
  author = {Desvaux, M. and Gravière, A. and Grosjean, J. and Fiaux, E. and Rasoldier, V. and Étienne, M. and Ould-Slimane, M. and Cantogrel, P. and Curey-Levêque, S. and Lozouet, M. and Pouplin, S. and Lequerré, T. and Vittecoq, O. and Avenel, G.},
  title = {Étude des facteurs associés à un risque d’atteinte neurologique sévère dans les spondylodiscites infectieuses dans une cohorte de 329 cas},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2022},
  series = {35e {Congrès} {Français} de {Rhumatologie}},
  volume = {89},
  pages = {A47},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833022002563},
  doi = {10.1016/j.rhum.2022.10.056}
}

Abstract: Introduction
Devant une image de spondylodiscite (SD) sur l’imagerie, la SD infectieuse est l’étiologie la plus redoutée. L’enquête bactériologique n’est pas concluante dans environ 30 % des cas [1]. Au cours de ces dernières années, plusieurs étiologies de SD non infectieuses ont été décrites : inflammatoire, microcristalline, dégénérative. Notre travail consistait, à partir d’une population de SD suspectées à l’imagerie, à comparer les SD dont l’étiologie infectieuse était prouvée par une documentation bactériologique aux SD non documentées.
Patients et méthodes
À l’aide de l’entrepôt de données de santé, ont été recueillies toutes les suspicions de spondylodiscite hospitalisées dans un service de médecine ou de chirurgie de 2010 à 2020. L’analyse statistique a été faite par test exact de Fisher pour les données qualitatives et par test de Mann-Whitney pour les données quantitatives.
Résultats
Après analyse des 821 dossiers, 329 ont été inclus. Deux cent soixante-quinze SD (84  étaient documentées, dont 209 (75  par hémoculture et 68 (25  par une ponction-biopsie disco-vertébrale (PBDV). Cinquante-quatre (16  n’étaient pas documentées. Les SDI documentées (n = 275) étaient plus souvent fébriles (58,9 % vs 40,7 % chez les non documentées, p = 0,016), avaient un syndrome inflammatoire biologique plus important (CRP maximale à 187 ± 122mg/L vs 114 ± 109mg/L, p textless 0,0001), et étaient plus récentes (évolutiontextless1 mois pour 193 (70  vs 25 (46  pour les SD non documentées). L’analyse du sous-groupe de SD à hémoculture négative et qui ont du bénéficier d’une PBDV ne montrait pas de différence entre les SD documentées et non documentées. Parmi les 54 spondylodiscites non documentées, 37 ont reçu une antibiothérapie probabiliste, dont la majorité consistait en une association fluoroquinolone et rifampicine. Quinze patients n’ont pas reçu d’antibiotique, à 1 mois, le scanner montrait une stabilité des lésions, le taux CRP était normal et aucune complication n’était survenue. Deux patients ont été perdus de vue et l’évolution n’a pu être analysée. Parmi SD non documentées et non traitées, le diagnostic finalement retenu était majoritairement celui de discopathie dégénérative (7/15).
Conclusion
Dans cette cohorte, 16 % des SD n’étaient pas documentées. Les différences observées étaient surtout le fait des spondylodiscites très inflammatoires documentées par hémoculture. Aucune différence significative n’était mise en évidence entre la population des SD documentées et non documentées permettant de soutenir l’hypothèse d’une origine non bactérienne dans cette situation.
BibTeX:
@article{Graviere2022,
  author = {Gravière, A. and Desvaux, M. and Grosjean, J. and Fiaux, E. and Rasoldier, V. and Étienne, M. and Pouplin, S. and Lequerré, T. and Vittecoq, O. and Avenel, G.},
  title = {Analyse descriptive des spondylodiscites sans documentation bactériologique issues d’une cohorte de 329 spondylodiscites suspectées d’être infectieuses à l’imagerie},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2022},
  series = {35e {Congrès} {Français} de {Rhumatologie}},
  volume = {89},
  pages = {A47--A48},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833022002575},
  doi = {10.1016/j.rhum.2022.10.057}
}

Abstract: Introduction
L’omalizumab (OMA), anticorps monoclonal anti-IgE, peut être prescrit depuis 2015 en France dans les urticaires chroniques spontanées (UCS) résistantes aux antihistaminiques. Une rémission spontanée est possible et il n’existe pas de recommandation sur la durée optimale de traitement par OMA. Notre objectif était d’évaluer les modalités d’arrêt de l’OMA en vie réelle dans une cohorte multicentrique française.
Matériel et méthodes
Nous avons réalisé une étude observationnelle, rétrospective, dans 9 centres français affiliés au Groupe Urticaire de la SFD, incluant tous les patients ayant une UCS et/ou inductible (UCInd) traités par au moins une injection d’OMA entre janvier 2009 et janvier 2021 afin d’analyser la survie du traitement par OMA. La réponse au traitement par OMA a été évaluée 6 mois après le début du traitement en utilisant les scores PGA, UCT et UAS7 et leurs seuils habituels (réponse complète ou quasi-complète si UCTtextgreater12 et/ou UAS7textless6 et/ou PGA 0 ou 1). La réponse était considérée comme rapide si complète avant 3 mois d’OMA. La réponse aux traitements antérieurs à l’OMA était évaluée en utilisant les mêmes scores recueillis à des moments variables en raison du caractère rétrospectif de l’étude.
Résultats
Au total, 878 patients ont été inclus, avec une efficacité et tolérance de l’OMA semblables à la littérature. La réponse initiale était davantage complète et rapide chez les patients ayant une UCS versus UCInd (65,4 % vs 56,3 % respectivement) et en l’absence de comorbidité auto-immune (64,4 % vs 51,6 . Au total, 408 patients (46,5  ont arrêté l’OMA au cours du suivi et 198 de ces patients l’ont repris après 7,7 mois en moyenne avec une efficacité retrouvée. Après 1 an de suivi, 66 % des patients n’avaient encore jamais interrompu l’OMA. Les raisons d’arrêt de l’OMA étaient : l’obtention d’un bon contrôle de l’urticaire (n=203, 23,1 , l’inefficacité de l’OMA (n=88, 10 , la survenue d’une contre-indication (n=44, 5 , des motifs personnels (n=35, 4 , des effets indésirables (n=23, 2,6 , ou inconnues (n=15, 1,8 . Les patients atopiques et ceux ayant eu des thérapeutiques antérieures autres que les antihistaminiques (et hors AMM, telles que l’hydroxychloroquine) étaient ceux qui arrêtaient l’OMA le plus précocement pour bon contrôle de l’urticaire. En revanche, les patients ayant une UCInd et ceux ayant une comorbidité auto-immune arrêtaient l’OMA de façon plus précoce pour inefficacité, effets indésirables, survenue d’une contre-indication ou pour motifs personnels. Les femmes arrêtaient plus précocement l’OMA que les hommes pour apparition d’une contre-indication (telle qu’une grossesse). Chez l’ensemble des patients, une durée plus longue de l’urticaire était associée à un traitement plus prolongé par OMA.
Discussion
Les facteurs qui semblent avoir influencé la survie du traitement par OMA dans cette étude reflètent probablement des différences de réponse à l’OMA entre certaines sous-populations d’urticariens chroniques, comme déjà décrit dans la littérature sur de plus faibles effectifs : les patients atopiques semblaient meilleurs répondeurs que ceux ayant une comorbidité auto-immune ou une UCInd. Des études prospectives comparant et évaluant différentes modalités d’arrêt de l’OMA après obtention d’un bon contrôle de l’urticaire sont nécessaires afin d’optimiser la prise en charge individuelle.
BibTeX:
@article{Litovsky2022,
  author = {Litovsky, J. and Paryl, M. and Hacard, F. and Tétart, F. and Boccon Gibod, I. and Dezoteux, F. and Staumont-Sallé, D. and Darrigade, A. S. and Doutre, M. S. and Milpied, B. and Soria, A. and Amsler, E. and Bernier, C. and Perrot, J. L. and Raison Peyron, N. and Mura, T. and Grosjean, J. and Du Thanh, A.},
  title = {Étude de survie du traitement par omalizumab dans une cohorte multicentrique française de patients atteints d’urticaire chronique},
  month = {November},
  journal = {Annales de Dermatologie et de Vénéréologie - FMC},
  year = {2022},
  series = {Journées dermatologiques de {Paris}, 29 novembre - 3 décembre 2022},
  volume = {2},
  number = {8, Supplement 1},
  pages = {A65},
  url = {https://www.sciencedirect.com/science/article/pii/S2667062322003373},
  doi = {10.1016/j.fander.2022.09.063}
}

BibTeX:
@inproceedings{2022,
  author = {Marc Jamoulle},
  title = {Post-acute sequelae of SARS-CoV-2 infection or Long Covid},
  booktitle = {WICC annual meeting},
  year = {2022},
  url = {https://orbi.uliege.be/bitstream/2268/294818/1/_Post-acute%20sequelae%20of%20SARS-CoV-2%20infection.pdf}
}

BibTeX:
@inproceedings{Jamoulle2022,
  author = {Marc Jamoulle},
  title = {Somes issues in the field of classification and terminology. Notes about ICPC-3},
  booktitle = {WICC annual meeting},
  year = {2022},
  url = {https://orbi.uliege.be/bitstream/2268/294821/1/WICC%20Copenhagen.pdf}
}

BibTeX:
@inproceedings{Leguillon2022,
  author = {Romain Léguillon and Laura Gosselin and Christophe Carnoy and Thibaut Pressat-Laffouilhère and Catherine Letord and Badisse Dahamna and Stéfan Darmoni and Julien Gr},
  title = {A new knowledge organisation for monoclonal antibodies use authorised in Europe: a multi-terminology thesaurus to facilitate queries within clinical data warehouses},
  booktitle = {JNRB 2022 Journée Normandie de recherche biomédicale},
  year = {2022}
}

Abstract: Contexte : cet article présente une recherche financée par l’Agence Nationale de la Recherche (ANR) sur la conception d’une aide à la décision de prescription d’applications mobiles de santé pour les médecins généralistes français. Objectif et méthode : Cette recherche, proposée par un consortium interuniversitaire, est devenue, en cours d’élaboration, interdisciplinaire en partenariat avec les patients. L’article éclaire tant les phases constituées mobilisant à tour de rôle les différents chercheurs, professionnels, citoyens et patients, les modalités de partenariat initiés, que les résultats de la recherche. Conclusion : Parmi la pléthore d’applications mobiles en santé mises sur le marché, un processus d’évaluation critique a été conçu permettant une aide à la décision de prescription d’application mobile. La méthodologie mobilisée participe à une approche participative de tous les acteurs du Soin dont les patients font aujourd’hui partie, une manière d’appréhender la complexité qui permet de relever les défis d’adhésion du plus grand nombre.
BibTeX:
@article{Flora2022,
  author = {Flora, Luigi and Darmon, David and Darmoni, Stefen Sd and Julien, Grosjean and Simon, Christian and Hassanaly, Parina and Dufour, Jean-Charles},
  title = {Innover en partenariat par la création d'une aide à la décision d'application mobiles dans la relation médecin-patient : {La} recherche {ApiAppS}},
  journal = {La revue sur le partenariat de soin avec le patient : analyses},
  year = {2022},
  number = {4},
  pages = {73},
  url = {https://hal.science/hal-03717896}
}

Abstract: Avec l'adoption généralisée des dossiers médicaux électroniques (DME), des quantités de plus en plus importantes de données cliniques électroniques sont générées, ce qui fait que les chercheurs, les administrateurs de soins de santé et les cliniciens s'intéressent de plus en plus à l'utilisation de telles données. Le projet EDSaNCoh, sélectionné et financé par le FEDER (Fonds européen de développement régional), vise à développer une plateforme pour créer et alimenter automatiquement des e-cohortes prospectives. L'objectif final du projet est d'optimiser la recherche non interventionnelle sur les données épidémiologiques et cliniques en réduisant les erreurs humaines, la charge de travail, la complexité de la saisie des données et le temps consacré à la collecte des données par rapport aux méthodes de recherche actuelles, ce qui se traduit finalement par une réduction des coûts. Le premier projet tirant parti de l'infrastructure EDSaNCoh est EDILS2.0 (Eating Disorders Inventory Longitudinal Study) dont l'objectif principal est d'identifier, 2 et 5 ans après une première consultation pour Trouble du Comportement Alimentaire (TCA), les facteurs pronostiques de guérison, de rémission, de changement de type de trouble alimentaire et de décès ou suicide. METHODOLOGIE : Trois sont les sources de données combinées par l'infrastructure EDSaNCoh : l'entrepôt de données de santé du CHU de Rouen, le SNDS (système national des données de santé), et des questionnaires auto-administrables directement envoyés aux patients. Afin d'évaluer les capacités de l'algorithme construit pour EDILS2.0 à identifier correctement les patients répondant aux critères d'inclusion et à récupérer correctement les variables ciblées, ses performances ont été comparées automatiquement, sur un ensemble de documents aléatoires, à un gold standard humain. textlessbrtextgreaterRESULTATS : textlessbrtextgreaterL'algorithme a donné de bons résultats, atteignant 96 % de précision et 88,1 % de recall pour l'inclusion des patients. En ce qui concerne ses capacités d'extraction de caractéristiques, il a obtenu, sur un ensemble de 24 variables, une accuracy moyenne de 94,08%. CONCLUSION : Selon les résultats préliminaires, EDILS2.0 montre une qualité de données très prometteuse, une qualité qui est, je crois, encore améliorable. Les optimisations suggérées sont de nature conservatrice, elles sont faciles à mettre en œuvre et ne nécessitent pas d'adaptations des pratiques de travail, ce qui devrait se traduire par une mise en œuvre sans friction. En cas de succès, elles feront passer la précision de l'algorithme d'extraction des caractéristiques dans une "zone de confiance", au-delà de la barre des 95 ce qui est crucial pour la fiabilité des analyses futures. Tel résultat servira également de manifeste des bons résultats que l'on peut obtenir avec les e-cohortes et de la qualité du projet EDSaNCoh et favorisera l'intérêt pour cette technologie.
BibTeX:
@phdthesis{Monti2022,
  author = {Monti, Francesco},
  title = {{EDSaNCoh} et {EDILS2}.0 : résultats préliminaires et perspectives},
  month = {October},
  school = {Université de Rouen Normandie},
  year = {2022},
  note = {Pages: 49},
  url = {https://dumas.ccsd.cnrs.fr/dumas-03858400}
}

2021


BibTeX:
@article{Deroualle2021,
  author = {Deroualle, Tiffany and Dominique, Stéphane and Monti, Francesco and Grosjean, Julien and Darmoni, Stéfan and Lequerré, Thierry and Vittecoq, Olivier},
  title = {Rheumatologic manifestations of sarcoidosis and increased risk of spondyloarthritis occurrence. {A} retrospective single center case-control study},
  month = {December},
  journal = {Joint Bone Spine},
  year = {2021},
  volume = {88},
  number = {6},
  pages = {105247},
  doi = {10.1016/j.jbspin.2021.105247}
}

Abstract: BACKGROUND:
PubMed is one of the most important basic tools to access medical literature. Semantic query expansion using synonyms can improve retrieval efficacy.
OBJECTIVE:
The objective was to evaluate the performance of three semantic query expansion strategies.
METHODS:
Queries were built for forty MeSH descriptors using three semantic expansion strategies (MeSH synonyms, UMLS mappings, and mappings created by the CISMeF team), then sent to PubMed. To evaluate expansion performances for each query, the first twenty citations were selected, and their relevance were judged by three independent evaluators based on the title and abstract.
RESULTS:
Queries built with the UMLS expansion provided new citations with a slightly higher mean precision (74.19%) than with the CISMeF expansion (70.28%), although the difference was not significant. Inter-rater agreement was 0.28. Results varied greatly depending on the descriptor selected.
DISCUSSION:
The number of citations retrieved by the three strategies and their precision varied greatly according to the descriptor. This heterogeneity could be explained by the quality of the synonyms. Optimal use of these different expansions would be through various combinations of UMLS and CISMeF intersections or unions.
CONCLUSION:
Information retrieval tools should propose different semantic expansions depending on the descriptor and the search objectives.
BibTeX:
@article{Massonaud2019,
  author = {Clément Massonaud and Romain Lelong and Gaétan Kerdelhué and Emeline Lejeune and Julien Grosjean and Nicolas Griffon and Stéfan Darmoni},
  title = {Performance evaluation of three semantic expansions to query {PubMed}},
  journal = {Health Information and Libraries Journal},
  year = {2021},
  volume = {38},
  number = {2},
  pages = {113-124},
  doi = {10.1111/hir.12291}
}

Abstract: OBJECTIVES: To introduce the 2021 International Medical Informatics Association (IMIA) Yearbook by the editors.
METHODS: The editorial provides an introduction and overview to the 2021 IMIA Yearbook whose special topic is "Managing Pandemics with Health Informatics - Successes and Challenges". The Special Topic, the keynote paper, and survey papers are discussed. The IMIA President's statement and the IMIA dialogue with the World Health Organization are introduced. The sections' changes in the Yearbook Editorial Committee are also described.
RESULTS: Health informatics, in the context of a global pandemic, led to the development of ways to collect, standardize, disseminate and reuse data worldwide: public health data but also information from social networks and scientific literature. Fact checking methods were mostly based on artificial intelligence and natural language processing. The pandemic also introduced new challenges for telehealth support in times of critical response. Next generation sequencing in bioinformatics helped in decoding the sequence of the virus and the development of messenger ribonucleic acid (mRNA) vaccines.
CONCLUSIONS: The Corona Virus Disease 2019 (COVID-19) pandemic shows the need for timely, reliable, open, and globally available information to support decision making and efficiently control outbreaks. Applying Findable, Accessible, Interoperable, and Reusable (FAIR) requirements for data is a key success factor while challenging ethical issues have to be considered.
BibTeX:
@article{Soualmia2021,
  author = {Soualmia, Lina F. and Hollis, Kate Fultz and Mougin, Fleur and Séroussi, Brigitte},
  title = {Health {Data}, {Information}, and {Knowledge} {Sharing} for {Addressing} the {COVID}-19},
  month = {August},
  journal = {Yearbook of Medical Informatics},
  year = {2021},
  volume = {30},
  number = {1},
  pages = {4--7},
  doi = {10.1055/s-0041-1726541}
}

Abstract: BACKGROUND: The roll-out of COVID-19 vaccines is a multi-faceted challenge whose performance depends on pace of vaccination, vaccine characteristics and heterogeneities in individual risks.
METHODS: We developed a mathematical model accounting for the risk of severe disease by age and comorbidity, and transmission dynamics. We compared vaccine prioritisation strategies in the early roll-out stage and quantified the extent to which measures could be relaxed as a function of the vaccine coverage achieved in France.
FINDINGS: Prioritizing at-risk individuals reduces morbi-mortality the most if vaccines only reduce severity, but is of less importance if vaccines also substantially reduce infectivity or susceptibility. Age is the most important factor to consider for prioritization; additionally accounting for comorbidities increases the performance of the campaign in a context of scarce resources. Vaccinating 90% of ≥65 y.o. and 70% of 18-64 y.o. before autumn 2021 with a vaccine that reduces severity by 90% and susceptibility by 80 we find that control measures reducing transmission rates by 15-27% should be maintained to remain below 1000 daily hospital admissions in France with a highly transmissible variant (basic reproduction number R0  = 4). Assuming 90% of ≥65 y.o. are vaccinated, full relaxation of control measures might be achieved with a vaccine coverage of 89-100% in 18-64 y.o or 60-69% of 0-64 y.o.
INTERPRETATION: Age and comorbidity-based vaccine prioritization strategies could reduce the burden of the disease. Very high vaccination coverage may be required to completely relax control measures. Vaccination of children, if possible, could lower coverage targets necessary to achieve this objective.
BibTeX:
@article{TranKiem2021,
  author = {Tran Kiem, Cécile and Massonnaud, Clément R. and Levy-Bruhl, Daniel and Poletto, Chiara and Colizza, Vittoria and Bosetti, Paolo and Fontanet, Arnaud and Gabet, Amélie and Olié, Valérie and Zanetti, Laura and Boëlle, Pierre-Yves and Crépey, Pascal and Cauchemez, Simon},
  title = {A modelling study investigating short and medium-term challenges for {COVID}-19 vaccination: {From} prioritisation to the relaxation of measures},
  month = {August},
  journal = {EClinicalMedicine},
  year = {2021},
  volume = {38},
  pages = {101001},
  doi = {10.1016/j.eclinm.2021.101001}
}

Abstract: INTRODUCTION: A fire at the Lubrizol chemical factory in Rouen on September 26, 2019 generated a huge column of smoke directed northeast toward the city. As the eye might be particularly affected by the smoke and other toxic emissions from the fire, we assessed the impact of this industrial and ecological disaster on irritative eye surface disease in the week following the accident.
MATERIALS AND METHODS: We retrospectively collected the medical data of the patients who presented to the Ophthalmology Emergency Department (OED) of Rouen University Hospital (the only OED open during the days following the accident) during the week following the fire (W1). We compared these data with those of patients who presented during the week before the fire (W-1). We also collected data on patients presenting to the ED in general during W-1 and W1, including the number of visits directly related to the fire.
RESULTS: 361 patients presented to the OED during W1 following the fire, compared with 384 in W-1. Of these patients, 83 (23 had ocular surface disease in W1, versus 76 (20 in W-1. Conjunctivitis was found in 54 patients in W1 (39 viral, 9 allergic, 6 undetermined) versus 44 in W-1 (27 viral, 12 allergic, 5 undetermined). A dry irritative syndrome was present in 29 patients in W1 versus 32 in W-1. Only 4 patients directly attributed their symptoms to the fire: 2 viral conjunctivitis, 1 allergic conjunctivitis and 1 worried patient (at D2, D5, D7 and D7 following the fire respectively).
DISCUSSION: The number of emergency eye consultations did not change in the week following the Lubrizol factory fire (except for a decrease the day of the accident, related to the lock-down). There was a higher number of consultations in W1 for conjunctivitis, mostly viral in appearance and probably not directly related to the fire. The number of consultations for dry irritative syndrome was comparable between the two periods. Despite major media coverage of the event at the national level and a very high level of concern among the population, the fire does not seem to have had an effect on OED activity at Rouen University Hospital, nor on general ED visits. The stay-at-home order on the first day may have had a protective effect, avoiding direct exposure to smoke. The long-term consequences of the soot deposits on the ground as the smoke cloud passed over remain undetermined and are under surveillance. A review of the literature on the ocular consequences of industrial accidents is presented.
CONCLUSION: The Ophthalmology Emergency Department did not record increased activity in the week following the Lubrizol Rouen fire, and ocular surface disease did not give rise to more consultations than the week before the fire. This suggests that there was no or minimal immediate ocular toxicity of the smoke from the fire.
BibTeX:
@article{huard_impact_2021,
  author = {Huard, J. and Gueudry, J. and Leroy, J.-P. and Joly, L.-M. and Muraine, M.},
  title = {Impact de l’incendie de l’usine {Lubrizol} à {Rouen} le 26 septembre 2019 sur la fréquentation des urgences ophtalmologiques},
  month = {October},
  journal = {Journal Francais D'ophtalmologie},
  year = {2021},
  volume = {44},
  number = {8},
  pages = {1121--1128},
  doi = {10.1016/j.jfo.2020.07.022}
}

Abstract: Résumé
Introduction
Plusieurs bases de données existent dans le domaine de la santé au travail et le Plan National Santé Travail en a demandé une cartographie. Quatre d’entre elles sont analysées du point de vue de leur complémentarité et intersection. Sumer explore les expositions aux risques professionnels via l’expertise du médecin du travail. Evrest étudie les conditions de travail du point de vue des salariés ainsi que leur santé. MCP recense les pathologies en lien avec le travail et les expositions suspectées d’en être à l’origine. RNV3P identifie des associations entre expositions et pathologie via la cotation d’une imputabilité sur des critères scientifiques et non médico-légaux.
Objectif
Montrer la complémentarité de ces dispositifs à partir d’un exemple sur les femmes aides à domicile (FAAD).
Méthode
Au sein de chaque dispositif, les FAAD et les autres femmes ont été comparées. Puis, les résultats des 4 dispositifs ont été comparés entre eux.
Résultats
Les effectifs étaient de 425, 10 852, 797, 463 FAAD et 10 966, 263 384, 26 245, 11 253 autres femmes respectivement pour Evrest, MCP, RNV3P et Sumer. Par comparaison avec les autres femmes, les FAAD sont significativement plus âgées, plus souvent à temps partiel, exposées à des contraintes physiques ou biomécaniques, présentent plus souvent des affections de l’appareil locomoteur mais pas plus fréquemment de souffrance psychique. Enfin, le RNV3P enregistre des pathologies cutanées ou respiratoires alors qu’elles sont peu rapportées dans MCP.
Discussion
Chaque dispositif apporte des informations en lui-même mais le rapprochement des résultats des dispositifs, même s’ils n’explorent pas strictement les mêmes populations, apporte des informations complémentaires sur les différences de points de vue concernant les expositions entre salariés et professionnels de santé, les problèmes de santé des salariés liés ou non au travail, et les phénomènes conduisant à une sous déclaration en maladie professionnelle…
Summary
Introduction
Different health and work databases exist in France and the Occupational Health National Plan 2016-2020 asked to map them. Complementarity and intersection were studied for four of them. Sumer studies occupational expositions using occupational health practitioner expertise. Evrest studies working conditions perceived by workers and health, independently of his link with work. MCP studies pathologies caused by work and describes suspected link with exposures. RNV3P describes associations between exposures and pathologies and establishes an imputability degree, using scientific criterias and not medico-legal criteria.
Aim
The aim of this article is to show complementarity of 4 systems (Sumer, Evrest, MCP, RNV3P), using the example of a study describing women home help workers (WHWW).
Methods
In each system, WHHW were compared with other women workers. Then, results from each system were compared.
Results
Population was composed by 425, 10,852, 797, 463 WHHW and 10,966, 263,384, 26,245, 11,253 other women workers for Evrest, MCP, RNV3P et Sumer databases, respectively. By comparison with other women workers, WHHW were significantly older, working part-time, exposed to occupational physical and biomechanical constraints and had more often musculo-skeletal affections, but mental affections were not more frequent. RNV3P recorded cutaneous and respiratory pathologies whereas MCP did not.
Discussion
Bring together, the 4 systems give more information even if they don’t study same populations: for example, about different points of view of workers and occupational health professionals, about health problems differences when studying pathologies in general in workers or occupational diseases, about occupational pathology declaration to the social health system…
BibTeX:
@article{Rollin2021,
  author = {Rollin, L. and Andujar, P. and Bloch, J. and Chatelot, J. and Coutrot, T. and Dewitte, J. D. and Homere, J. and Léonard, M. and Leroyer, A. and Memmi, S. and Nisse, C. and Rosankis, E. and Tone, F. and Vongmany, N.},
  title = {Quelle complémentarité pour les dispositifs en santé travail ({Evrest}, {MCP}, {Sumer}, {RNV3P}) : un exemple à partir des métiers de l’aide à domicile chez les femmes ?},
  month = {May},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2021},
  volume = {82},
  number = {3},
  pages = {261--276},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878520311115},
  doi = {10.1016/j.admp.2020.11.002}
}

Abstract: Résumé
Objectifs
L’état de la démographie médicale en France a été globalement à la baisse depuis plusieurs années. Afin de limiter la baisse des effectifs de médecin du travail, le statut de collaborateur médecin a été créé. Notre but est d’évaluer le ressenti des conditions de travail des collaborateurs médecins et de le comparer à celui des internes de médecine et santé au travail.
Méthodes
Un questionnaire destiné à effectuer une enquête transversale a été utilisé. Le questionnaire a été administré à la population d’intérêt via LimeSurvey. Quatre universités du Nord-Ouest de la France où les inscriptions au DIU et au DES sont possibles ont été invitées à contribuer à notre étude.
Resultats
Les médecins du travail anciens internes le meilleur ressenti de leur conditions de travail (EVA (Échelle visuelle analogique) médiane=8). Ceci bien qu’ils aient le ressenti de la pression temporelle la plus forte (supérieure à 5 sur 10 dans 71 . Cette dernière est à mettre en perspective avec le fait qu’ils exercent plus souvent sur un mode de temps partiel. Il existe une différence significative du ressenti de la qualité de la formation entre les médecins en formation et les praticiens ayant fini leur cursus (p=0,004).
Conclusion
Le profil particulier du collaborateur médecin pourrait être un élément qui pourrait influencer la collaboration avec la médecine de ville.
Summary
Purpose of the study
The medical demographics in France have been generally declining for several years. In order to limit the decline in the number of occupational physicians, the status of physician collaborator has been created. Our goal is to assess the way working conditions were perceived by physicians and compare it to that of occupational work residents.
Methods
A questionnaire intended to carry out a cross-sectional survey was used. The questionnaire was administered to the targeted population via LimeSurvey. Four universities in the North-West of France where enrollments for both physicians and residents are possible were invited to contribute to our study.
Results
Former occupational medicine interns have the best perception of their working conditions (median VAS=8). Although they felt the greatest time pressure (over 5 out of 10 in 71. The latter should be put into perspective with the fact that they work more often on a part-time basis. There is a significant difference in the perception of the quality of training between doctors in training and full-fledged physicians (P=0.004).
Conclusion
The particular profile of the physician collaborator could be an element which could influence the collaboration with general practioners.
BibTeX:
@article{Sakhri2021,
  author = {Sakhri, R. and Soenen, P. and Géhanno, J. F. and Rollin, L.},
  title = {Comparaison du ressenti des conditions de travail et de l’évaluation de la formation : collaborateurs médecins vs internes},
  month = {November},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2021},
  volume = {82},
  number = {6},
  pages = {577--585},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878521001284},
  doi = {10.1016/j.admp.2021.06.007}
}

BibTeX:
@article{Bouteiller2021,
  author = {Bouteiller, Julie and Grosjean, Julien and Delaunay, Juliette and Jachiet, Marie and Bara, Corina and Nosbaum, Audrey and Bouschon, Pauline and Milpied, Brigitte and Oro, Saskia and Assier, Haudrey and others},
  title = {{\'E}ruptions ecz{\'e}matiformes chroniques du sujet {\^a}g{\'e}: quelle imputabilit{\'e} m{\'e}dicamenteuse?},
  journal = {Annales de Dermatologie et de V{\'e}n{\'e}r{\'e}ologie-FMC},
  publisher = {Elsevier},
  year = {2021},
  volume = {1},
  number = {8},
  pages = {A116--A117},
  doi = {10.1016/j.fander.2021.09.540}
}

Abstract: Introduction
Le syndrome SAPHO (synovite, acné, pustulose palmoplantaire, hyperostose et ostéite) est une entité radio-clinique associant des atteintes articulaires, osseuses et cutanées inflammatoires. La présentation clinique de cette maladie est très hétérogène rendant le diagnostic difficile. La stratégie thérapeutique dans le syndrome SAPHO est mal définie. Le traitement de première intention reste les AINS à la demande qui s’avèrent efficaces pour traiter les poussées douloureuses mais deviennent rapidement insuffisants chez 60 % des cas au cours de l’évolution de la maladie. Les anti-TNF-a sont réservés aux formes réfractaires et leur efficacité est incertaine [1]. Les biphosphonates semblent avoir un intérêt potentiel [2]. L’objectif principal de ce travail était d’étudier la réponse à un traitement par bisphosphonate (BP) et/ou immunosuppresseurs (IS) (cDMARDs) ou biomédicaments (bDMARDs) selon la forme clinique rhumatologique de SAPHO (à prédominance osseuse versus à prédominance articulaire ou mixte).
Patients et méthodes
Ont été inclus dans les centres de Rouen (grâce à l’entrepôt de données de santé), Caen, Le Havre, Dieppe et Lillebonne tous les patients âgés de 18 ans ou plus, atteints d’un syndrome SAPHO répondant aux critères de Benhamou dont les données cliniques, biologiques et radiologiques étaient disponibles dans les dossiers et qui ont bénéficié d’au moins un traitement IS ou BP pour leur maladie. Chaque examen d’imagerie a été relu en aveugle des traitements par un radiologue ayant une expertise en ostéo-articulaire. Les patients étaient classés en 2 groupes (osseux versus articulaire/mixte) selon les données d’imagerie et l’histoire clinique. La réponse au traitement était considérée positive si les symptômes étaient améliorés d’au moins 50 % (cut-off retenu dans la littérature). Un test du Chi2 a été utilisé pour les variables qualitatives, et un test de Kruskal-Wallis pour les variables quantitatives à l’aide du logiciel SPSS.
Résultats
Un total de 34 patients atteints de SAPHO et ayant bénéficié d’un traitement IS ou BP ont été inclus et répartis de la façon suivante : 13 dans le groupe osseux et 21 dans le groupe articulaire ou mixte. Les 2 groupes étaient comparables sur les données démographiques, la durée de suivi, l’âge d’entrée dans la maladie, l’existence d’une atteinte dermatologique ou d’une MICI associée, l’exposition au tabac, la durée d’exposition à un anti-inflammatoire préalable ou à un antibiotique. Seule l’atteinte thoracique antérieure était plus fréquemment notée dans le groupe osseux (p=0,042). L’attitude thérapeutique des prescripteurs différait significativement entre les 2 groupes (p=0,043) avec une prescription plus importante de BP en première ligne dans le groupe osseux (5/13 patients) et un IS dans le groupe articulaire/mixte (19/21). Concernant l’efficacité des traitements, 10/13 patients ont bénéficié d’un traitement efficace sans échappement au cours de leur suivi dans le groupe osseux, ce qui n’était pas significativement différent du groupe articulaire ou mixte (17/21). Les BP ont permis d’obtenir une efficacité sans échappement dans un nombre de cas significativement plus élevé dans le groupe osseux alors qu’il s’agissait des IS dans le groupe articulaire ou mixte (p=0,002). Le groupe osseux a eu recours à un nombre de lignes de traitements spécifiques (IS ou BP) significativement plus faible que dans le groupe articulaire/mixte. (1 ligne spécifique vs au moins 2) (p=0,046).
Conclusion
LLes BP semblent plus efficaces dans le SAPHO avec atteinte osseuse prédominante. Celle-ci semble plus facile à traiter comparativement aux formes articulaires ou mixtes de SAPHO.
BibTeX:
@article{Brevet2021,
  author = {Brevet, P. and Marcelli, C. and Alcaix, D. and Leclancher, A. and Bacquet, H. and Grosjean, J. and Michelin, P. and Lequerré, T. and Vittecoq, O.},
  title = {Étude de la relation entre la nature du traitement et la réponse thérapeutique selon la forme clinique du syndrome {SAHO} à partir d’une cohorte multicentrique normande analysée rétrospectivement},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2021},
  series = {34e {Congrès} {Français} de {Rhumatologie}},
  volume = {88},
  pages = {A113--A114},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833021004385},
  doi = {10.1016/j.rhum.2021.10.179}
}

Abstract: Introduction
Le CEC survient principalement chez des personnes âgées et entraîne une morbidité non négligeable du fait de ses localisations et de son potentiel métastatique. Les CEC localisés aux membres inférieurs ont des caractéristiques cliniques distinctes. Le traitement de référence est la chirurgie et en cas de contre-indication, la radiothérapie est une alternative thérapeutique possible mais cette prise en charge peut s’avérer délicate en cas de localisation à la jambe, de pathologies vasculaires ou de comorbidités, entraînant un retard de cicatrisation. L’objectif de notre étude était d’évaluer quels étaient les facteurs associés à l’absence de cicatrisation à 6 mois après traitement.
Matériel et méthodes
Il s’agissait d’une étude descriptive rétrospective monocentrique sur une cohorte de patients pris en charge en dermatologie pour un CEC localisé à la jambe entre 2000 et 2020. Les données ont été recueillies à partir des dossiers médicaux avec relecture systématique du dossier. Nous avons noté les caractéristiques des patients, du CEC, le type de traitement réalisé, les complications survenues au décours, les récidives locales ou les métastases, la cicatrisation complète à 6 mois après le traitement.
Résultats
Nous avons retenu 100 dossiers sur cette période. L’âge moyen des patients était de 78,4 ans avec une prédominance de femmes (67 . On retrouvait une AOMI dans 6 % des cas, un diabète (13 , une insuffisance veineuse (18 , des troubles neuro-cognitifs (10 . Il s’agissait de CE de novo (78  ou de Marjolin (22 . La chirurgie était le traitement le plus fréquemment réalisé (92, les autres patients étant traités par radiothérapie seule (7  ou immunothérapie (1 . Des complications survenaient chez 18 patients, le plus souvent infectieuses. La cicatrisation complète à 6 mois était obtenue chez 76 patients. À la date des dernières nouvelles 88 % des patients étaient en rémission complète. Chez les patients non cicatrisés on notait un traitement par radiothérapie plus fréquent (20,8 % vs 2,6 , un taux plus élevé de complications (28,6 % vs 16,4 , des comorbidités plus fréquentes (AOMI : 12,5 % vs 3,9 ; insuffisance veineuse : 29,2 % vs 14,5 ; diabète: 29,2 % vs 7,9  et un taux plus élevé de récidive (17,4 % vs 10,6 .
Discussion
Ces résultats montrent un taux élevé de patients non cicatrisés à 6 mois après traitement d’un CEC de jambe, majoré lorsqu’un traitement par radiothérapie a été réalisé et que le patient présente des comorbidités à type de pathologies vasculaires aux membres inférieurs ou de diabète. Ce retard de cicatrisation expose les patients à davantage de complications notamment infectieuses. La recherche et le contrôle de ces facteurs doivent faire partie de la prise en charge globale du patient âgé.
BibTeX:
@article{Huard2021,
  author = {Huard, Emma and Tedbirt, Billal and Mignard, Claire and Grosjean, Julien and Courville, Philippe and Joly, Pascal and Carvalho, Priscille},
  title = {Prise en charge des carcinomes épidermoïdes cutanées localisés aux membres inférieurs. Étude d’une cohorte de 100 patients},
  month = {December},
  journal = {Annales de Dermatologie et de Vénéréologie - FMC},
  year = {2021},
  series = {Journées dermatologiques de {Paris}, 30 novembre - 4 décembre 2021},
  volume = {1},
  number = {8, Supplement 1},
  pages = {A180--A181},
  url = {https://www.sciencedirect.com/science/article/pii/S2667062321003664},
  doi = {10.1016/j.fander.2021.09.089}
}

Abstract: Introduction
Le syndrome de chevauchement polyarthrite rhumatoïde (PR)/sclérodermie systémique (ScS) est une association rare et peu étudiée. Elle concerne 5 % des patients atteints de ScS. Seules des études ouvertes ayant évalué les biomédicaments (bDMARDs) ont rapporté des résultats encourageants, notamment sur l’atteinte articulaire. La prise en charge de ces patients n’est donc pas codifiée. L’objectif était d’analyser en conditions réelles la stratégie thérapeutique et la réponse aux bDMARDS, avec un focus sur l’atteinte articulaire.
Patients et méthodes
Nous avons analysé rétrospectivement sur une période de 10 ans les caractéristiques cliniques, biologiques, radiographiques et la prise en charge thérapeutique des patients respectant les critères diagnostics ACR/EULAR de la PR et de la ScS dans deux centres universitaires. La réponse aux bDMARD a été évaluée sur le plan articulaire (selon les critères EULAR pour 19 séquences, sur le maintien thérapeutique pour 2 séquences) ainsi que sur l’atteinte pulmonaire (évolution des EFR).
Résultats
Vingt-deux patients ont été identifiés. L’atteinte pulmonaire interstitielle était fréquente (n=11). Seulement 7 patients ont été traités uniquement par traitement de fond conventionnel. La molécule la plus utilisée était le méthotrexate. Le recours aux bDMARD était fréquent (15/22), significativement plus important chez les patients ayant des facteurs rhumatoïdes (OR 26,7 ; p=0,004) et avec une tendance chez les patients ayant un plus haut taux d’anti-CCP (160 vs 15 UI ; p=0,11) ou une pneumopathie interstitielle diffuse (OR 10,6 ; p=0,063). Le tocilizumab a été le traitement le plus choisi (n=8) suivi du rituximab (n=5), de l’abatacept et des anti-TNF (n=4 respectivement). Les bDMARD à visée anti-lymphocytaire (abatacept, rituximab) permettaient généralement une réponse bonne ou modérée (n=9/10) avec une diminution significative du DAS28 à 6 mois (−1,75 ; p=0,016). Les bDMARD à visée anti-cytokinique (tocilizumab, etanercept, infliximab) ont moins fréquemment permis un contrôle de l’atteinte articulaire (réponse bonne ou modérée : n=3/9) avec une diminution du DAS28 à 6 mois moins importante (−0,79 ; p=0,36). Deux séquences concernant le tocilizumab ont eu un arrêt précoce pour intolérance ne permettant pas leur évaluation. Un patient a reçu du tofacitinib avec une bonne réponse clinique mais avec un arrêt à 9 mois pour intolérance. Les données EFR n’ont pas évolué significativement sous bDMARD.
Discussion
Le tocilizumab a été fréquemment utilisé, notamment à partir de 2016, date à laquelle une efficacité sur l’atteinte pulmonaire chez les patients atteints de ScS a été évoquée. La forte prévalence de l’atteinte pulmonaire interstitielle dans notre série, notamment chez les patients non contrôlés par traitement de fond conventionnel, a pu influencer le choix thérapeutique. Pour autant le tocilizumab n’a pas permis une bonne réponse sur le plan articulaire dans la majorité des cas.
Conclusion
Chez les patients ayant à la fois une PR et une ScS réfractaire aux traitements de fond conventionnels, les bDMARDs à visée anti-lymphocytaire (abatacept, rituximab) ont permis une amélioration plus fréquente et plus marquée de l’atteinte articulaire que les bDMARD anti-cytokiniques.
BibTeX:
@article{Lebel2021,
  author = {Lebel, N. and Marie, I. and Marcelli, C. and Dumont, A. and Grosjean, J. and Levesque, H. and Leclercq, M. and Lequerré, T. and Benhamou, Y. and Vittecoq, O.},
  title = {Étude observationnelle bi-centrique sur la prise en charge thérapeutique des patients atteints simultanément d’une polyarthrite rhumatoïde et d’une sclérodermie},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2021},
  series = {34e {Congrès} {Français} de {Rhumatologie}},
  volume = {88},
  pages = {A142--A143},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833021004816},
  doi = {10.1016/j.rhum.2021.10.222}
}

Abstract: Introduction
Les anticorps anti-peptides-cycliques-citrullinées (anti-CCP) sont des biomarqueurs fiables pour caractériser les patients atteints de polyarthrite rhumatoïde (PR). Des études ont montré que leur positivité pouvait influencer la réponse aux biomédicaments. L’objectif de notre étude était de déterminer si le titre des anti-CCP à l’introduction du traitement est prédictif de rémission chez les patients traités par abatacept, inhibiteurs du facteur de nécrose tumorale alpha (anti-TNF-α) ou tocilizumab.
Matériels et méthodes
Dans cette étude observationnelle, rétrospective, ont été inclus des patients atteints de PR suivis au C.H.U. de X, traités par abatacept, anti-TNF-α ou par tocilizumab entre octobre 2009 et mai 2021. Les patients ont été séparés en 3 groupes : anti-CCP négatifs, anti-CCP positifstextless340UI/mL et anti-CCP positifstextgreater340UI/mL, et cela pour chaque biomédicament. Pour savoir s’il existe un lien entre le titre des anti-CCP et l’obtention d’une rémission ou d’une faible activité (définies par le DAS28) à 12 mois de traitement, des analyses univariées et multivariées avec ajustement sur les caractéristiques initiales ont été réalisées. Une analyse en sous groupe a également été effectuée en distinguant parmi les patients traités par anti-TNF-α ceux traités par etanercept de ceux traités par un anti-TNF-α monoclonal.
Résultats
Parmi les 329 patients inclus, 99 étaient traités par abatacept (28 anti-CCP négatifs, 40 anti-CCP positifstextless340UI/mL et 31 anti-CCP positifstextgreater340UI/mL), 180 par anti-TNF-α (38 anti-CCP négatifs, 93 anti-CCP positifstextless340UI/mL et 49 anti-CCP positifstextgreater340UI/mL) et 50 par tocilizumab (11 anti-CCP négatifs, 23 anti-CCP positifstextless340UI/mL et 16 anti-CCP positifstextgreater340UI/mL). L’âge médian des patients à l’introduction du traitement était de 57 [47–67] ans. Le sex-ratio était de 2,96 femmes pour 1 homme. La durée d’évolution médiane de la PR avant l’initiation du biomédicament était de 7 [2–12] ans ; 73,6 % des patients présentaient une atteinte structurale. Pour chacune des molécules, les caractéristiques des patients à l’introduction du biomédicament étaient comparables, quel que soit le titre des anti-CCP, sauf pour les facteurs rhumatoïdes (FR) dont la positivité était moins fréquente dans les groupes anti-CCP négatifs. Après analyse univariée puis ajustement sur les caractéristiques initiales, aucune association significative n’a été montrée entre le titre des anti-CCP et la proportion de rémission ou de faible activité chez les patients traités par abatacept, anti-TNF-α ou tocilizumab. Dans l’analyse en sous-groupe, le titre des anti-CCP semblait influencer la rémission avec l’etanercept, mais pas avec les anti-TNF-α monoclonaux. Cette association n’était pas retrouvée en analyse multivariée.
Conclusion
Le titre des anti-CCP à l’introduction du biomédicament n’a pas d’impact sur l’obtention d’une rémission selon le DAS28 après un délai de 12 mois de traitement par abatacept, anti-TNF-α ou tocilizumab.
BibTeX:
@article{protat_impact_2021,
  author = {Protat, P. and Blavier, P. and Vannier, M. and Grosjean, J. and Jouen, F. and Darmoni, S. and Lequerré, T. and Vittecoq, O.},
  title = {Impact du titre des anticorps anti-peptides cycliques citrullinés sur l’obtention de la rémission dans la polyarthrite rhumatoïde traitée par abatacept, tocilizumab ou anti-{TNFα}},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2021},
  series = {34e {Congrès} {Français} de {Rhumatologie}},
  volume = {88},
  pages = {A78},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833021003823},
  doi = {10.1016/j.rhum.2021.10.123}
}

BibTeX:
@article{laffouilh232_ontological_2021,
  author = {Pressat Laffouilhère, Thibaut and Grosjean, Julien and Bénichou, Jacques and Darmoni, Stefan J. and Soualmia, Lina F.},
  title = {Ontological {Models} {Supporting} {Covariates} {Selection} in {Observational} {Studies}},
  journal = {Studies in Health Technology and Informatics},
  year = {2021},
  pages = {1095--1096},
  note = {Publisher: IOS Press},
  url = {https://ebooks.iospress.nl/doi/10.3233/SHTI210361},
  doi = {10.3233/SHTI210361}
}

BibTeX:
@article{soualmia_patient_2021,
  author = {Soualmia, Lina F. and Lafon, Vincent and Darmoni, St\&\#233 and J, Fan},
  title = {Patient and {Graph} {Embeddings} for {Predictive} {Diagnosis} of {Drug} {Iatrogenesis}},
  journal = {Public Health and Informatics},
  year = {2021},
  pages = {482--483},
  note = {Publisher: IOS Press},
  url = {https://ebooks.iospress.nl/doi/10.3233/SHTI210205},
  doi = {10.3233/SHTI210205}
}

BibTeX:
@article{Darmoni2001a,
  author = {Stéfan J. Darmoni},
  title = {IA au sein d’un entrepôt de données de santé à Rouen},
  month = {04},
  journal = {Bulletin de l’AfIA},
  year = {2021},
  number = {112},
  pages = {18-20},
  url = {https://afia.asso.fr/wp-content/uploads/2021/05/112_avr21.pdf#page=19}
}

Abstract: Background: Many drugs are still being prescribed in a "off-label mode" and especially in psychiatry. Off-label prescription situations may vary depending on several factors and such practice is not well identifiable in the literature. Methods: A new public academic drug database has been recently created and is able to contain off-label indications, especially in psychiatry in the context of the PSYHAMM French research project. For each situation, bibliographic references have been collected to make the scientific information available to all. Results: this new off-label drug database contains more than 18,154 lines. It is freely available at https://www.hetop.eu/hetop/medicaments. Several off-label usages have been formally described and the system is extensible to all drugs and all specialties. Conclusion: An off-label drug database can be a valuable tool for health professionals and students.
BibTeX:
@techreport{Grosjean2021a,
  author = {Grosjean, Julien and Letord, Catherine and Zana, Ilan and Advenier-Iakovlev, Emanuelle and Duclos, Catherine and Krebs, Marie-Odile and Charlet, Jean and Darmoni, Stefan Jacques},
  title = {Off-label drug database},
  month = {November},
  school = {Health Informatics},
  year = {2021},
  url = {http://medrxiv.org/lookup/doi/10.1101/2021.11.25.21266864},
  doi = {10.1101/2021.11.25.21266864}
}

BibTeX:
@article{Kerdelhue2021,
  author = {Gaétan Kerdelhué and Julien Grosjean and Kévin Billey and Stéfan J Darmoni},
  title = {La base de données bibliographiques LiSSa (Littérature Scientifique en SAnté)},
  month = {Avril-Mai},
  journal = {Le Manipulateur d'imagerie médicale et de radiothérapie},
  year = {2021},
  number = {306},
  pages = {42-46}
}

2020


Abstract: In the context of the COVID-19 pandemic, wearing a face mask has become usual and ubiquitous, in both hospitals and community. However, the general public is consuming surgical or filtering face piece (FFP) masks irrespective of their specificity, leading to global supply shortage for the most exposed persons, which are healthcare workers. This underlines the urgent need to clarify the indications of the different categories of mask, in order to rationalize their use. The study herein specifies the French position for the rational use of respiratory protective equipment for healthcare workers.
BibTeX:
@article{Lepelletier2020,
  author = {Lepelletier, Didier and Grandbastien, Bruno and Romano-Bertrand, Sara and Aho, Serge and Chidiac, Christian and Géhanno, Jean-François and Chauvin, Franck and {French Society for Hospital Hygiene and the High Council for Public Health}},
  title = {What face mask for what use in the context of {COVID}-19 pandemic? {The} {French} guidelines},
  month = {April},
  journal = {The Journal of Hospital Infection},
  year = {2020},
  doi = {10.1016/j.jhin.2020.04.036}
}

Abstract: Background: With the continuous expansion of available biomedical data, efficient and effective information retrieval has become of utmost importance. Semantic expansion of queries using synonyms may improve information retrieval.
Objective: The aim of this study was to automatically construct and evaluate expanded PubMed queries of the form "preferred term"[MH] OR "preferred term"[TIAB] OR "synonym 1"[TIAB] OR "synonym 2"[TIAB] OR …, for each of the 28,313 Medical Subject Heading (MeSH) descriptors, by using different semantic expansion strategies. We sought to propose an innovative method that could automatically evaluate these strategies, based on the three main metrics used in information science (precision, recall, and F-measure).
Methods: Three semantic expansion strategies were assessed. They differed by the synonyms used to build the queries as follows: MeSH synonyms, Unified Medical Language System (UMLS) mappings, and custom mappings (Catalogue et Index des Sites Médicaux de langue Française [CISMeF]). The precision, recall, and F-measure metrics were automatically computed for the three strategies and for the standard automatic term mapping (ATM) of PubMed. The method to automatically compute the metrics involved computing the number of all relevant citations (A), using National Library of Medicine indexing as the gold standard ("preferred term"[MH]), the number of citations retrieved by the added terms ("synonym 1"[TIAB] OR "synonym 2"[TIAB] OR …) (B), and the number of relevant citations retrieved by the added terms (combining the previous two queries with an "AND" operator) (C). It was possible to programmatically compute the metrics for each strategy using each of the 28,313 MeSH descriptors as a "preferred term," corresponding to 239,724 different queries built and sent to the PubMed application program interface. The four search strategies were ranked and compared for each metric.
Results: ATM had the worst performance for all three metrics among the four strategies. The MeSH strategy had the best mean precision (51%, SD 23%). The UMLS strategy had the best recall and F-measure (41%, SD 31% and 36%, SD 24%, respectively). CISMeF had the second best recall and F-measure (40%, SD 31% and 35%, SD 24%, respectively). However, considering a cutoff of 5%, CISMeF had better precision than UMLS for 1180 descriptors, better recall for 793 descriptors, and better F-measure for 678 descriptors.
Conclusions: This study highlights the importance of using semantic expansion strategies to improve information retrieval. However, the performances of a given strategy, relatively to another, varied greatly depending on the MeSH descriptor. These results confirm there is no ideal search strategy for all descriptors. Different semantic expansions should be used depending on the descriptor and the user's objectives. Thus, we developed an interface that allows users to input a descriptor and then proposes the best semantic expansion to maximize the three main metrics (precision, recall, and F-measure).
BibTeX:
@article{Massonnaud2018,
  author = {Massonnaud, Clément R and Kerdelhué, Gaetan and Grosjean, Julien and Lelong, Romain and Griffon, Nicolas and Darmoni, Stefan J},
  title = {Identification of the Best Semantic Expansion to Query PubMed Through Automatic Performance Assessment of Four Search Strategies on All Medical Subject Heading Descriptors: Comparative Study},
  month = {June},
  journal = {JMIR Medical Informatics},
  year = {2020},
  volume = {8},
  number = {6},
  pages = {e12799},
  url = {https://medinform.jmir.org/2020/6/e12799/},
  doi = {10.2196/12799}
}

Abstract: Screening and management of frail elderly patients is essential in general practice.
OBJECTIVE: This study aims to describe and evaluate the knowledge about frailty, its screening tests and management in a population of general practice interns.
METHOD: A prospective, descriptive and mono-centric study using an online survey was conducted. The 2018's promotion of general practice interns in Rouen's University participated. Evaluation of the general knowledge (e.g diagnostic criteria) and specific knowledge (e.g ranking different conditions such as: undernourishment leading to asthenia) and management algorithm (e.g to address the patient for geriatric evaluation) Results: 90 questionnaires were analyzed. Ten interns (11 stated to know at least one screening test or to know a set of 4 major frailty criteria. Thirty four interns knew at least 4 frailty criteria (major or minor) and 46 interns had partial knowledge. Fried's phenotype was the most known. Seventy-five interns (83 stated to know the frailty syndrome. However, 88% of the interns had little knowledge about its pathophysiology. Concerning frailty management, 78% (70 interns) stated to know how to screen frailty and prescribe first line treatments. Thirty-one among them knew how to reassess initial treatment if failure. In 59 interns (65, identifying frailty would have led to a geriatric consultation. Seventy-nine interns (87 were favorable to go through further training on frailty.
CONCLUSION: These general practice interns were able to identify frailty criterion but, in contrast, global understanding of the syndrome was missing. Further training about this topic seems to be necessary.
BibTeX:
@article{Piedallu2020,
  author = {Piedallu, Jean-Baptiste and Lorenzo-Villalba, Noël and Chassagne, Philippe and Schuers, Mathieu and Zulfiqar, Abrar-Ahmad},
  title = {Frailty syndrome: evaluation of its knowledge and screening tools by general medicine interns},
  month = {March},
  journal = {Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement},
  year = {2020},
  volume = {18},
  number = {1},
  pages = {53--62},
  doi = {10.1684/pnv.2019.0840}
}

Abstract: BACKGROUND: The definition and the treatment of male urinary tract infections (UTIs) are imprecise. This study aims to determine the frequency of male UTIs in consultations of general practice, the diagnostic approach and the prescribed treatments.
METHODS: We extracted the consultations of male patients, aged 18 years or more, during the period 2012-17 with the International Classification of Primary Care, version 2 codes for UTIs or associated symptoms from PRIMEGE/MEDISEPT databases of primary care. For eligible consultations in which all symptoms or codes were consistent with male UTIs, we identified patient history, prescribed treatments, antibiotic duration, clinical conditions, additional examinations and bacteriological results of urine culture.
RESULTS: Our study included 610 consultations with 396 male patients (mean age 62.5 years). Male UTIs accounted for 0.097% of visits and 1.44 visits per physician per year. The UTIs most commonly identified were: undifferentiated (52, prostatitis (36, cystitis (8.5 and pyelonephritis (3.5. Fever was recorded in 14% of consultations. Urine dipstick test was done in 1.8% of consultations. Urine culture was positive for Escherichia coli in 50.4% of bacteriological tests. Fluoroquinolones were the most prescribed antibiotics (64.9, followed by beta-lactams (17.4, trimethoprim-sulfamethoxazole (11.9 and nitrofurantoin (2.6.
CONCLUSIONS: Male UTIs are rare in general practice and have different presentations. The definition of male UTIs needs to be specified by prospective studies. Diagnostic evidence of male cystitis may reduce the duration of antibiotic therapy and spare critical antibiotics.
BibTeX:
@article{Soudais2020,
  author = {Soudais, Benjamin and Lacroix-Hugues, Virginie and Meunier, François and Gillibert, André and Darmon, David and Schuers, Matthieu},
  title = {Diagnosis and management of male urinary tract infections: a need for new guidelines. {Study} from a {French} general practice electronic database},
  month = {December},
  journal = {Family Practice},
  year = {2020},
  doi = {10.1093/fampra/cmaa136}
}

BibTeX:
@article{Lesueur2020,
  author = {Lesueur, N. and Gehanno, J.F. and Lefebvre, A. and Michelot, F. and Leroyer, A. and Rollin, L.},
  title = {Facteurs de risques psychosociaux sur l'état de santé du personnel hospitalier : étude comparative dans un centre hospitalier universitaire français},
  journal = {Sciences et bonheur},
  year = {2020},
  volume = {4},
  number = {1},
  pages = {54--72},
  note = {Pages: 4 1 ,54–72},
  url = {https://sciencesetbonheur.files.wordpress.com/2018/09/lesueur-et-al.-2020-sciences-bonheur-volume-4.pdf}
}

Abstract: Résumé
But
En deux décennies, la télédermatologie est devenue une des applications les plus développées de la télémédecine. Son déploiement nécessite d’être accompagné par des évaluations de qualité. Pour réaliser ces évaluations, des indicateurs précis et mesurables doivent être définis. L’objectif de cette étude était d’identifier de manière exhaustive les indicateurs permettant d’évaluer les procédures de télédermatologie et d’évaluer leur pertinence et leurs résultats.
Méthodes
Revue systématique de la littérature conduite sur MEDLINE via PubMed jusqu’en septembre 2017, à partir d’une requête comportant les termes MeSH suivants : « telemedicine », « dermatology », « quality improvement ».
Résultats
La requête a identifié 372 articles, dont 127 ont été retenus. Quatorze indicateurs ont été identifiés et répartis en quatre catégories : indicateurs de processus, de qualité, de coût et de satisfaction. La fiabilité diagnostique de la télédermatologie était l’indicateur le plus souvent évalué (49 études). Elle était globalement bonne comparée à la consultation conventionnelle. Les coûts étaient généralement moindres. Les résultats de certains indicateurs étaient difficiles à comparer et donc à généraliser du fait de l’absence d’instrument de mesure validé, notamment pour la satisfaction.
Conclusion
La télédermatologie est un outil prometteur. Sa mise en place doit s’adapter aux différents besoins des territoires et être réfléchie avec les patients et les différents professionnels de santé concernés. Son évaluation devra également être spécifique à chaque terrain et se baser sur des indicateurs standardisés.
Summary
Aim
Over the last two decades teledermatology has become one of the most widely used applications in telemedicine. Wide-ranging medico-economic evaluations are necessary to facilitate its deployment. “Accurate and measurable” indicators must be defined in order to enable high-quality assessments to be performed. The objective of this study is to identify all indicators allowing evaluation of teledermatology procedures and to assess the relevance and results thereof.
Materials and methods
A literature search until September 2017 was conducted in PubMed using the following MeSH search terms: “telemedicine”, “dermatology” and “quality improvement”.
Results
The search identified 372 articles, of which 127 were included. Fourteen indicators were identified and split into 4 categories: processes indicators, quality indicators, cost indicators and satisfaction indicators. Reliability of diagnosis was the most widely evaluated indicator (49 studies). It was good overall compared to conventional consultations. Costs were generally reduced. Due to the absence of a validated measuring tool, it was difficult to compare the results for certain indicators, particularly satisfaction, and thus to make any generalizations.
Conclusion
Teledermatology is a promising tool. Its deployment must be adapted to the various needs in the field and achievement of this goal requires consultation with patients and with the different healthcare professionals involved. Its evaluation must also be specific to each terrain and must employ standardized measuring instruments.
BibTeX:
@article{Ridard2020,
  author = {Ridard, E. and Secember, H. and Carvalho-Lallement, P. and Schuers, M.},
  title = {Indicateurs en télédermatologie : une revue de la littérature},
  month = {July},
  journal = {Annales de Dermatologie et de Vénéréologie},
  year = {2020},
  url = {http://www.sciencedirect.com/science/article/pii/S0151963820302702},
  doi = {10.1016/j.annder.2020.01.024}
}

BibTeX:
@article{Rollin2020a,
  author = {Rollin, L. and Buisset, C. and Cormorèche, C. and Leroyer, A. and Lenôtre, C. and Gilles, M. and Barlet, B. and Moliné, A.F. and Volkoff, S.},
  title = {Comment " marchent " des chiffres en santé au travail dans l'entreprise ? {A} propos des enjeux sociaux dans les usages de l'observatoire {EVREST}},
  journal = {Références en Santé au Travail},
  year = {2020},
  volume = {162},
  pages = {41--49}
}

Abstract: INTRODUCTION: Return to work after cancer is a determinant of patients quality of life. The aims were to describe return-to-work interventions applied in a French University Hospital and to assess its effectiveness in achieving a successful return to work.
METHODS: A return-to-work questionnaire was sent to 153 patients who were accompanied by a multidisciplinary return-to-work after cancer consultation.
RESULTS: hundred and twenty-one patients answered the return-to-work questionnaire. Analysis of the questionnaire found an overall rate of return to work of 50% two years after the cancer diagnosis. The rate was significantly higher in patients who had received individual psychological support for returning to work (P=0.04) and higher, but not significantly, in patients who had a consultation with the company physician during their period of sick-leave (P=0.08). Participating in support groups and performing the required actions for the recognition of handicapped worker status were not factors associated with return to work.
DISCUSSION: An individual psychological support for returning to work and a consultation with the company physician during the period of sick-leave should be systematically recommended for patients suffering from cancer. Participating in support groups and recognition of handicapped worker status should be recommended on a case-by-case basis.
BibTeX:
@article{Rollin2020,
  author = {Rollin, Laétitia and De Blasi, Geraldine and Boucher, Line and Bouteyre, Evelyne and Gehanno, Jean-François},
  title = {Return-to-work support in cancer patients: {Which} methodology?},
  month = {February},
  journal = {Bulletin Du Cancer},
  year = {2020},
  volume = {107},
  number = {2},
  pages = {200--208},
  doi = {10.1016/j.bulcan.2019.10.006}
}

Abstract: A lexical method was used to map ICD-11 to the terminologies included in the HeTOP server. About half of ICD-11 codes (47.76 were mapped to at least one concept. The developed tool reached a global precision of 0.98 and a recall of 0.66. Lexical methods are powerful methods to map health terminologies. Supervised and manual mapping is still necessary to complete the mapping.
BibTeX:
@article{Grosjean2020,
  author = {Grosjean, Julien and Billey, Kévin and Charlet, Jean and Darmoni, Stefan J.},
  title = {Manual {Evaluation} of the {Automatic} {Mapping} of {International} {Classification} of {Diseases} ({ICD})-11 (in {French}).},
  month = {June},
  journal = {Studies in health technology and informatics},
  year = {2020},
  volume = {270},
  pages = {1335--1336},
  note = {Place: Netherlands},
  url = {http://ebooks.iospress.nl/volume/digital-personalized-health-and-medicine-proceedings-of-mie-2020},
  doi = {10.3233/SHTI200429}
}

BibTeX:
@article{Deroualle2020,
  author = {Deroualle, T. and Dominique, S. and Darmoni, S. and Grosjean, J. and Monti, F. and Lequerré, T. and Vittecoq, O.},
  title = {Les formes rhumatologiques de la sarcoïdose sont associées à un risque accru de développer une spondyloarthrite : résultats d’une étude cas-témoins monocentrique rétrospective},
  month = {December},
  journal = {Revue du rhumatisme},
  year = {2020},
  volume = {87},
  pages = {A98--A99},
  note = {Publisher: Paris : Elsevier},
  url = {https://www.lissa.fr/fr/rep/articles/EL_S1169833020303641},
  doi = {10.1016/j.rhum.2020.10.170}
}

BibTeX:
@inproceedings{Dusenne2020,
  author = {Mikaël Dusenne and Julien Grosjean and Lina Soualmia and Clément Massonnaud and Stéphane Canu and Stéfan J. Darmoni},
  title = {Exploitation de documents médicaux par les techniques d’embedding : application au typage automatique de documents},
  booktitle = {Actes de la journée Santé \& IA},
  month = {Juin},
  year = {2020},
  url = {http://pfia2020.fr/wp-content/uploads/2020/09/actes_journeeSanteIA_2020.pdf}
}

Abstract: Résumé
La crise inédite du Covid-19 a fait apparaitre le besoin de recenser et de diffuser des supports didactiques thérapeutiques à destination des patients (auto-rééducation) en complément des séances, notamment dans le cadre du télésoin. Kinedoc, la banque documentaire francophone, a collaboré avec le D2IM du CHU de Rouen pour créer ce nouveau type de documents en adaptant le moteur de recherche du CISMeF qui recense déjà des publications similaires dans d’autres domaines. Désormais, il sera possible de trouver et de télécharger dans Kinedoc des brochures thérapeutiques dont le Collège de la Masso-Kinésithérapie (CMK) aura préalablement validé la conformité. Chaque société savante, association ou kinésithérapeute/physiothérapeute peut proposer de partager ses « brochures pédagogiques pour le patient », en les envoyant par courriel à cette adresse : secretariat@college-mk.org.
With this unprecedented Covid-19 crisis, appeared the need to draw up a list and to spread pedagogical and therapeutic media for patients (self-rehabilitation), in addition to sessions, particularly in "telehealth". Kinedoc, a French database, collaborated with the D2IM of Rouen’s university hospital to create this new type of documents, adjusting CISMeF’s search engine, which has already listed similar publications in other fields. From now on, it will be possible to find and download in Kinedoc therapeutic brochures certified by the "Collège de la Masso-Kinésithérapie" (CMK). Every academic society, association or physiotherapist can suggest sharing its "pedagogical brochures for patients" by sending them to this address: secretariat@college-mk.org.
BibTeX:
@article{Kerdelhue2020,
  author = {Kerdelhué, Gaétan and Grosjean, Julien and Lejeune, Emeline and Letord, Catherine and Darmoni, Stéfan and Oviève, Jean-Marc and Martin, Laurélyne and Gedda, Michel},
  title = {Kinedoc, {CISMeF} et {COVID}-19: la nécessité de référencer les brochures pédagogiques pour le patient},
  month = {May},
  journal = {Kinésithérapie, la Revue},
  year = {2020},
  url = {http://www.sciencedirect.com/science/article/pii/S1779012320301790},
  doi = {10.1016/j.kine.2020.05.010}
}

BibTeX:
@unpublished{Kiem2020,
  author = {Kiem, C{\'e}cile Tran and Massonnaud, Cl{\'e}ment and Levy-Bruhl, Daniel and Poletto, Chiara and Colizza, Vittoria and Bosetti, Paolo and Gabet, Am{\'e}lie and Olie, Val{\'e}rie and Zanetti, Laura and Bo{\"e}lle, Pierre-Yves and Crepey, Pascal and Cauchemez, Simon},
  title = {{Evaluation des strat{\'e}gies vaccinales COVID-19 avec un mod{\`e}le math{\'e}matique populationnel}},
  month = {December},
  school = {{Haute Autorit{\'e} de Sant{\'e} ; Institut Pasteur Paris ; Sant{\'e} publique France}},
  year = {2020},
  note = {working paper or preprint},
  url = {https://hal-pasteur.archives-ouvertes.fr/pasteur-03087143}
}

Abstract: Europe is now considered as the epicenter of the SARS-CoV-2 pandemic, France being among the most impacted country. In France, there is an increasing concern regarding the capacity of the healthcare system to sustain the outbreak, especially regarding intensive care units (ICU). The aim of this study was to estimate the dynamics of the epidemic in France, and to assess its impact on healthcare resources for each French metropolitan Region. We developed a deterministic, age-structured, Susceptible-Exposed-Infectious-Removed (SEIR) model based on catchment areas of each COVID-19 referral hospitals. We performed one month ahead predictions (up to April 14, 2020) for three different scenarios (R0 = 1.5, R0 = 2.25, R0 = 3), where we estimated the daily number of COVID-19 cases, hospitalizations and deaths, the needs in ICU beds per Region and the reaching date of ICU capacity limits. At the national level, the total number of infected cases is expected to range from 22,872 in the best case (R0 = 1.5) to 161,832 in the worst case (R0 = 3), while the total number of deaths would vary from 1,021 to 11,032, respectively. At the regional level, all ICU capacities may be overrun in the worst scenario. Only seven Regions may lack ICU beds in the mild scenario (R0 = 2.25) and only one in the best case. In the three scenarios, Corse may be the first Region to see its ICU capacities overrun. The two other Regions, whose capacity will be overrun shortly after are Grand-Est and Bourgogne-Franche-Comté. Our analysis shows that, even in the best case scenario, the French healthcare system will very soon be overwhelmed. While drastic social distancing measures may temper our results, a massive reorganization leading to an expansion of French ICU capacities seems to be necessary to manage the coming wave of critically affected COVID-19 patients.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe study was funded by the French national research agency (ANR) through the SPHINx (Spread of Pathogens on Healthcare Institutions Networks) project.Author DeclarationsAll relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.YesAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data and source code are available upon request.
BibTeX:
@article{Massonnaud2020,
  author = {Massonnaud, Cl{\'e}ment and Roux, Jonathan and Cr{\'e}pey, Pascal},
  title = {COVID-19: Forecasting short term hospital needs in France},
  journal = {medRxiv},
  publisher = {Cold Spring Harbor Laboratory Press},
  year = {2020},
  url = {https://www.medrxiv.org/content/early/2020/03/20/2020.03.16.20036939},
  doi = {10.1101/2020.03.16.20036939}
}

Abstract: On March 16 2020, French authorities ordered a large scale lockdown to counter the COVID-19 epidemic wave rising in the country, stopping non-essential economic, educational, and entertainment activities, maintaining mainly food retailers and healthcare institutions. One month later, the number of new hospitalizations and ICU admissions had reached a plateau and were beginning a slow descent.We developed a spatialized, deterministic, age-structured, and compartmental SARS-CoV-2 transmission model able to reproduce the pre-lockdown dynamic of the epidemic in each of the 13 French metropolitan regions. Thanks to this model, we estimate, at regional and national levels, the total number of hospitalizations, ICU admissions, hospital beds requirements (hospitalization and ICU), and hospital deaths which may have been prevented by this massive and unprecedented intervention in France.If no control measures had been set up, between March 19 and April 19 2020, our analysis shows that almost 23% of the French population would have been affected by COVID-19 (14.8 million individuals). Hence, the French lockdown prevented 587,730 hospitalizations and 140,320 ICU admissions at the national level. The total number of ICU beds required to treat patients in critical conditions would have been 104,550, far higher than the maximum French ICU capacity. This first month of lockdown also permitted to avoid 61,739 hospital deaths, corresponding to a 83.5% reduction of the total number of predicted deaths.Our analysis shows that in absence of any control measures, the COVID-19 epidemic would have had a critical morbidity and mortality burden in France, overwhelming in a matter of weeks French hospital capacities.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe study was partly funded by the French national research agency (ANR) through the SPHINx (Spread of Pathogens on Healthcare Institutions Networks) project.Author DeclarationsAll relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.YesAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesSource code is available upon request.
BibTeX:
@article{Roux2020.04.22.20075705,
  author = {Roux, Jonathan and Massonnaud, Cl{\'e}ment and Cr{\'e}pey, Pascal},
  title = {COVID-19: One-month impact of the French lockdown on the epidemic burden},
  journal = {medRxiv},
  publisher = {Cold Spring Harbor Laboratory Press},
  year = {2020},
  url = {https://www.medrxiv.org/content/early/2020/04/27/2020.04.22.20075705},
  doi = {10.1101/2020.04.22.20075705}
}

BibTeX:
@article{Trost2020,
  author = {Trost, Olivier and Crampon, Frédéric and Prum, Grégoire and Trouilloud, Pierre and Duparc, Fabrice},
  title = {A plea to remove the word "condyle" from the international anatomical nomenclature},
  month = {January},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2020},
  volume = {42},
  number = {1},
  pages = {95--96},
  doi = {10.1007/s00276-019-02296-7}
}

2019


Abstract: PURPOSE: Nasomaxillary fractures can be mistaken for fractures confined to the nasal bones, resulting in inappropriate treatments that jeopardize patient outcomes. Our purpose here was to provide information on nasomaxillary fractures via a retrospective study and literature review. MATERIAL AND METHODS: We retrospectively collected clinical, computed tomography (CT), therapeutic, and outcome data in consecutive patients managed for unilateral impacted nasomaxillary fractures at our centre over a 5-year period (2013-2017). Long-term outcomes were further assessed by administering scoring tools for subjectively assessed cosmesis, nasal obstruction, and pain during a telephone interview. RESULTS: The 11 included patients had a mean age of 33.4 years. The clinical manifestations included nasal asymmetry in all 11 patients and infra-orbital rim step-off deformity in 9 patients. Consistent CT findings were involvement of the nasal bone, canine pillar, and anterior maxillary bone; and presence of blood within the maxillary sinus. The treatment in 8 patients consisted in open reduction and internal fixation via the intraoral approach, with or without an added infra-orbital approach; 1 patient was managed by endonasal reduction and 2 patients declined reduction. Almost 1 year after surgery, the cosmetic outcome was good (mean score, 22/25) and few patients reported nasal obstruction (mean score, 3.6/20) or pain (mean score, 1.6/10). CONCLUSION: Nasomaxillary fracture is a specific entity that must be differentiated from nasal bone fracture. Open reduction and internal fixation via the intraoral approach, with an added infra-orbital approach if needed, provides good outcomes.
BibTeX:
@article{Adnot2019a,
  author = {Adnot, J. and Desbarats, C. and Joly, L.-M. and Trost, O.},
  title = {Nasomaxillary fracture: Retrospective review of 11 consecutive patients and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  volume = {120},
  number = {6},
  pages = {534--539},
  doi = {10.1016/j.jormas.2019.03.003}
}

Abstract: Dental rehabilitation raises specific challenges in patients with mandibular fibrous dysplasia. We report the 2-year post-operative outcomes on the normal and affected sides in a 64-year-old female with focal left mandibular fibrous dysplasia and bilateral posterior edentulism. On the left, bone shaving of the lesion to restore sufficient vertical height was followed by the insertion of two dental implants. Three dental implants were inserted into the normal bone on the right. Dental prostheses were added 6 months later. Two years after the first procedure, no complications had been recorded and the patient reported similar high satisfaction for both sides. This comparison of outcomes of dental implants inserted into dysplastic versus normal bone in the same patient suggests that dental implants may constitute a valid option for managing edentulism in selected patients with fibrous dysplasia, provided appropriate precautions are taken.
BibTeX:
@article{Adnot2019,
  author = {Adnot, J. and Moizan, H. and Trost, O.},
  title = {Dental implants in a patient with left mandibular fibrous dysplasia: Two-year outcomes on the normal and affected sides},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  volume = {120},
  number = {6},
  pages = {575--578},
  doi = {10.1016/j.jormas.2019.02.005}
}

Abstract: BACKGROUND: Extracting concepts from biomedical texts is a key to support many advanced applications such as biomedical information retrieval. However, in clinical notes Named Entity Recognition (NER) has to deal with various types of errors such as spelling errors, grammatical errors, truncated sentences, and non-standard abbreviations. Moreover, in numerous countries, NER is challenged by the availability of many resources originally developed and only suitable for English texts. This paper presents the Cimind system, a multilingual system dedicated to named entity recognition in medical texts based on a phonetic similarity measure. METHODS: Cimind performs entity recognition by combining phonetic recognition using the DM phonetic algorithm to deal with spelling errors and string similarity measures. Three main steps are processed to identify terms in a controlled vocabulary: normalization, candidate selection by phonetic similarity and candidate ranking. RESULTS: Cimind was evaluated in the 2016 and 2017 editions of the CLEF eHealth challenge in the CepiDC/CDC tasks. In 2017, it obtained on each corpus the following results: English dataset: 83.9% P, 78.3% R, 81.0% F1; French raw dataset: 85.7% P, 68.9% R, 76.4% F1; French aligned dataset: 83.5% P, 77.5% R, 80.4% F1. It ranked first in French and fourth in English in officials runs.
BibTeX:
@article{Cabot2019,
  author = {Cabot, Chloe and Darmoni, Stefan and Soualmia, Lina F.},
  title = {Cimind: {A} phonetic-based tool for multilingual named entity recognition in biomedical texts.},
  month = {June},
  journal = {Journal of biomedical informatics},
  year = {2019},
  volume = {94},
  pages = {103176},
  doi = {10.1016/j.jbi.2019.103176}
}

Abstract: PURPOSE: The objective of this study was to record the descriptive and metric anatomical characteristics of the thyrohyoid nerve with the aim of rerouting it in a selective laryngeal reinnervation procedure. METHODS: An anatomical study was performed on ten formalin-embalmed cadavers. The origin of the thyrohyoid nerve and the superior root of the ansa cervicalis, the location of the thyrohyoid nerve ending in the thyrohyoid muscle, and the recurrent laryngeal nerve were established. Then, a rerouting of the thyrohyoid nerve was performed. We measured the length of thyrohyoid nerve, the distance between the thyrohyoid nerve ending and the recurrent laryngeal nerve at the horizontal level of the cricothyroid joint before and after the rerouting, and the distance between the origin of the thyrohyoid nerve and the superior root of the ansa cervicalis. RESULTS: The thyrohyoid nerve was identified on both sides in all the cases. The average length of the thyrohyoid nerve was 27 mm. The end of the thyrohyoid nerve was found in 100% of the cases at the upper outer quarter of the thyrohyoid muscle. After the rerouting, an average reduction of 30% of the distance between the end of the thyroid nerve and the recurrent laryngeal nerve at the horizontal level of the cricothyroid joint was measured. CONCLUSION: The rerouting of the thyrohyoid nerve provided a reduction in the length of the nerve graft in laryngeal reinnervation. Moreover, the constancy of the thyrohyoid nerve and its characteristics make it a valuable anatomical base for laryngeal reinnervation and laryngeal innervated allotransplantation.
BibTeX:
@article{Crampon2019,
  author = {Crampon, Frédéric and Duparc, Fabrice and Trost, Olivier and Marie, Jean-Paul},
  title = {Selective laryngeal reinnervation: can rerouting of the thyrohyoid nerve simplify the procedure by avoiding the use of a nerve graft?},
  month = {February},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2019},
  volume = {41},
  number = {2},
  pages = {145--150},
  doi = {10.1007/s00276-018-2117-y}
}

Abstract: INTRODUCTION: Guidelines concerning the follow-up of subjects occupationally exposed to lung carcinogens, published in France in 2015, recommended the setting up of a trial of low-dose chest CT lung cancer screening in subjects at high risk of lung cancer. OBJECTIVE: To evaluate the organisation of low-dose chest CT lung cancer screening in subjects occupationally exposed to lung carcinogens and at high risk of lung cancer. METHODS AND ANALYSIS: This trial will be conducted in eight French departments by six specialised reference centres (SRCs) in occupational health. In view of the exploratory nature of this trial, it is proposed to test initially the feasibility and acceptability over the first 2 years in only two SRCs then in four other SRCs to evaluate the organisation. The target population is current or former smokers with more than 30 pack-years (who have quit smoking for less than 15 years), currently or previously exposed to International Agency for Research on Cancer group 1 lung carcinogens, and between the ages of 55 and 74 years. The trial will be conducted in the following steps: (1) identification of subjects by a screening invitation letter; (2) evaluation of occupational exposure to lung carcinogens; (3) evaluation of the lung cancer risk level and verification of eligibility; (4) screening procedure: annual chest CT scans performed by specialised centres and (5) follow-up of CT scan abnormalities. ETHICS AND DISSEMINATION: This protocol study has been approved by the French Committee for the Protection of Persons. The results from this study will be submitted to peer-reviewed journals and reported at suitable national and international meetings. TRIAL REGISTRATION NUMBER: NCT03562052; Pre-results.
BibTeX:
@article{Delva2019,
  author = {Delva, Fleur and Laurent, François and Paris, Christophe and Belacel, Milia and Brochard, Patrick and Bylicki, Olivier and Chouaïd, Christos and Clin, Benedicte and Dewitte, Jean-Dominique and Le Denmat, Véronique and Gehanno, Jean-François and Lacourt, Aude and Margery, Jacques and Verdun-Esquer, Catherine and Mathoulin-Pélissier, Simone and Pairon, Jean-Claude},
  title = {LUCSO-1-French pilot study of LUng Cancer Screening with low-dose computed tomography in a smokers population exposed to Occupational lung carcinogens: study protocol},
  journal = {BMJ open},
  year = {2019},
  volume = {9},
  number = {3},
  pages = {e025026},
  doi = {10.1136/bmjopen-2018-025026}
}

Abstract: Background: Word embedding technologies are now used in a wide range of applications. However, no formal evaluation and comparison have been made on models produced by the three most famous implementations (Word2Vec, GloVe and FastText).
Objective: The goal of this study is to compare embedding implementations on a corpus of documents produced in a working context, by health professionals.
Methods: Models have been trained on documents coming from the Rouen university hospital. This data is not structured and cover a wide range of documents produced in a clinic (discharge summary, prescriptions ...). Four evaluation tasks have been defined (cosine similarity, odd one, mathematical operations and human formal evaluation) and applied on each model.
Results: Word2Vec had the highest score for three of the four tasks (mathematical operations, odd one similarity and human validation), particularly regarding the Skip-Gram architecture.
Conclusions: Even if this implementation had the best rate, each model has its own qualities and defects, like the training time which is very short for GloVe or morphosyntaxic similarity conservation observed with FastText. Models and test sets produced by this study will be the first publicly available through a graphical interface to help advance French biomedical research.
BibTeX:
@article{Dynomant2019,
  author = {Dynomant, Emeric and Lelong, Romain and Dahamna, Badisse and Massonaud, Clément and Kerdelhué, Gaétan and Grosjean, Julien and Canu, Stéphane and Darmoni, Stefan J},
  title = {Word embedding for {French} natural language in healthcare: a comparative study},
  month = {April},
  journal = {JMIR Medical Informatics},
  year = {2019},
  pages = {30},
  doi = {10.2196/12310}
}

Abstract: BACKGROUND: Clinical research is mostly conducted among hospitalized patients, which restricts the generalizability of research results. The involvement of GPs in research has been consistently highlighted as a factor associated with successful study recruitment. OBJECTIVES: To assess GPs' motivations and willingness to participate in primary care research as investigators and to identify factors associated with their willingness. METHODS: We conducted an observational, cross-sectional study in Normandy, France, with a self-questionnaire sent to 3002 GPs. We collected data on GPs' socio-demographic characteristics, their experiences and their expectations regarding research, and their reasons for non-participation. RESULTS: Overall, 489 questionnaires were collected. Two hundred and forty-six GPs (50.3%) were interested in participating in clinical research as investigators. The two main conditions for participation as investigators were the relevance of the study topic for clinical practice (80.5%) and the feedback of study results (80.1%). The two main reasons for non-participation were lack of time (79.4%) and administrative burden (43.6%). Age between 27 and 34 years (adjusted odds ratio [AOR] = 2.86, P = 0.004) and GP trainer status (AOR = 2.41, P < 0.001) were associated with willingness to participate in primary care research. Age between 60 and 70 years (AOR = 0.53, P = 0.03) and locum status (AOR = 0.40, P = 0.04) were associated with non-participation in research. CONCLUSIONS: Based on our results, we were able to establish a profile of GPs willing to participate in primary care research as investigators. GPs' involvement should be based on their preferred areas of research. Different incentives such as a dedicated clinical research nurse or financial support could also be considered.
BibTeX:
@article{FerrandDevouge2019,
  author = {Ferrand Devouge, Eglantine and Biard, Morgane and Beuzeboc, Jean and Tavolacci, Marie-Pierre and Schuers, Matthieu},
  title = {Motivations and willingness of general practitioners in France to participate in primary care research as investigators},
  journal = {Family Practice},
  year = {2019},
  volume = {36},
  number = {5},
  pages = {552--559},
  doi = {10.1093/fampra/cmy126}
}

Abstract: BACKGROUND: Childhood obesity (CO) has become a true epidemic and a subject of increasing publications. The aim of this study was to assess if the number of publications in that field increases over time in proportion to the epidemic, and also according to socioeconomic factors.
METHODS: A PubMed search was carried out to extract articles related to CO published between 1945 and 2017. Data were downloaded from PubMed and processed through a dedicated parser. Socioeconomic data were collected from international organizations.
RESULTS: Overall, 36,554 articles were retrieved among 3329 journals, one-third of them being concentrated in 44 journals. The annual growth rate of publications on CO was on average 11.6% per year between 1990 and 2016, whereas the growth rate of articles on pediatrics or of the total articles indexed in MEDLINE was 2.6% and 4.4 respectively. The most productive countries were the United States (37.80, the United Kingdom (6.24, and Italy (4.56. There was a significant relationship between publications on CO in a country and prevalence of CO in that country (p = 0.002) and between evolution of the number of publications and evolution of the Human Development Index (p = 0.01). Following exponential growth, CO publications reached a plateau in 2013, whereas publications targeted on obesity in infants continue to increase.
CONCLUSIONS: Research on CO has risen markedly in the last two decades, with a higher growth rate than biomedical research overall, as a result of the worldwide obesity epidemic and also due to specific socioeconomic factors.
BibTeX:
@article{Gehanno2019,
  author = {Gehanno, Jean-Francois and Gehanno, Bogna and Schuers, Mathieu and Grosjean, Julien and Rollin, Laetitia},
  title = {Analysis of {Publication} {Trends} in {Childhood} {Obesity} {Research} in {PubMed} {Since} 1945},
  month = {March},
  journal = {Childhood Obesity (Print)},
  year = {2019},
  volume = {15},
  number = {4},
  pages = {227--236},
  doi = {10.1089/chi.2018.0276}
}

Abstract: INTRODUCTION: The pharmaceutical record system (PRS) is a French nationwide centralized electronic database shared among all community pharmacists listing all drugs dispensed by community pharmacists in the last four months. The objective of this study, the Medication Assessment Through Real time Information eXchange - Distributed Pharmaceutical Record System (MATRIX - DPRS) study, was to assess the clinical impact of the PRS upon granting access to physicians in three hospital specialties: anesthesiology, emergency medicine and geriatrics. MATERIAL AND METHODS: A multicenter prospective study was conducted in six hospital departments, two per specialty. Participating physicians noted medication information found exclusively in the pharmaceutical record (PR) of each patient unavailable elsewhere and any diagnostic or therapeutic management changes resulting from the PR information. The primary objective was to assess the proportion of diagnostic or therapeutic management changes attributable to the PR among patients who had an accessible PR. RESULTS: The inclusion level ranged from 1.1 to 30% in the six departments. The rate of diagnostic or therapeutic management changes was highest in geriatrics (n = 31/67; 46.3% 95% Confidence IntervaI (CI): 34.0-58.9 and lowest in anesthesiology (n = 36/227; 15.9% 95% CI: 11.4-21.3. Emergency medicine was intermediate (n = 5/22; 22.7% 95% CI: 7.8-45.4. CONCLUSION: Although the inclusion rate and statistical precision were low, these findings suggest that the information contained in the PRS is useful and may result in modifying patient management in a sizeable proportion of patients. This opens the prospect of evaluating other hospital specialties, as well as primary and secondary care settings.
BibTeX:
@article{Gillibert2019,
  author = {Gillibert, Andre and Griffon, Nicolas and Schuers, Matthieu and Hardy, Kristell and Elmerini, Amine and Letord, Catherine and Staccini, Pascal and Darmoni, Stefan J. and Benichou, Jacques},
  title = {Impact on medical practice of accessing pharmaceutical records},
  month = {January},
  journal = {International journal of medical informatics},
  year = {2019},
  volume = {121},
  pages = {58--63},
  doi = {10.1016/j.ijmedinf.2018.09.010}
}

Abstract: INTRODUCTION: La classification internationale des soins primaires, deuxième version (CISP-2) alignée sur la classification internationale des maladie dixième révision (CIM-10) est un standard pour le recueil épidémiologique en soins primaires. La CISP-2 convient aussi pour identifier les thèmes cliniques dont discutent les médecins de famille. Les domaines contextuels de connaissances spécifiques à la médecine de famille et aux Soins Primaires comme les structures, la gestion, les catégories de patients, les méthodes de recherche, les aspects éthiques ou environnementaux ne sont pas standardisés et reflètent le plus souvent des vues d'experts. METHODES: une méthode de recherche qualitative, appliquée à l'analyse de plusieurs congrès de médecine de famille a permis d'identifier, en plus des items cliniques, un ensemble de concepts contextuels abordés par les médecins de famille lors de leurs échanges pendant les congrès. Assemblés sous forme hiérarchique, ces concepts ont trouvé leur place au côté de la CISP-2, sous le nom de Q-codes version 2.5, sur le serveur sémantique multilingue multi-terminologique du Département d'Information et d'Informatique médicale (D2IM) de l'Université de Rouen, France. Les deux classifications sont éditées sous le sigle 3CGP pour Core Content Classification of General Practice. Ce serveur d'accès libre permet de consulter la CISP-2 en 22 langues et les Q-codes en dix langues. RESULTATS: le résultat de l'utilisation conjointe de ces deux classifications, comme descripteurs dans des congrès, pour identifier des concepts dans des textes, ou indexer la littérature grise en médecine de famille et soins primaires est présenté ici dans différentes utilisations pilotes. La validité et la généralisabilité de 3CGP semble bonne au vu des traductions déjà réalisées par des collègues du monde entier et de l'applicabilité de la méthode des deux côtés de l'Atlantique. Toute fois la reproductibilité et la variation inter-codeurs restent encore à tester pour les Q-codes. La question de la maintenance reste posée. CONCLUSION: grâce à cette méthode, on peut mettre en évidence l'extension conceptuelle, la complexité et la dynamique du métier de médecin généraliste et de famille et de médecin de soins primaires.
BibTeX:
@article{Jamoulle2019,
  author = {Jamoulle, Marc and Augusto, Daniel Knupp and Pizzanelli, Miguel and Tavares, Ariana De Oliveira and Resnick, Melissa and Grosjean, Julien and Darmoni, Stefan},
  title = {Une base de connaissance multilingue et dynamique en ligne pour la médecine générale et les soins primaires},
  journal = {Pan African Medical Journal},
  year = {2019},
  volume = {32},
  url = {http://www.panafrican-med-journal.com/content/article/32/66/full/},
  doi = {10.11604/pamj.2019.32.66.15952}
}

Abstract: Background: The huge amount of clinical, administrative and demographic data recorded and maintained by hospitals can be consistently aggregated into Health Data Warehouses (HDWs) with a uniform data model. In 2017, Rouen University Hospital (RUH) initiated the design of a Semantic Health Data Warehouse (SHDW) enabling both semantic description and retrieval of health information.
Objective: Our objectives were: first, to present a proof of concept of this SHDW, based on the data of 250,000 patients from RUH and second, to assess its ability to assist health professionals to select patients in a clinical trials context.
Methods: The SHDW relies on three distinct semantic layers: (a) a Terminology and Ontology (T&O) portal, (b) a Semantic Annotator and (c) a Semantic Search Engine and a Not Only SQL (NoSQL) layer to enhance data access performances. The system adopts an entity-centered vision which contrasts with the usually patient-centered vision adopted by existing systems such as Informatics for Integrating Biology and the Bedside (i2b2). This vision notably provides generic search capabilities able to express data requirements in terms of the whole set of interconnected conceptual entities that compose health information. We assessed the ability of the system to assist the search for 95 inclusion and exclusion criteria originating from five randomly chosen Clinical Trials from RUH.
Results: The system succeeded in fully automating 39.19% of the criteria and was efficiently used as a pre-screening tool for 72.97% of them.
Conclusions: The semantic aspect of the system combined with its generic entity-centered vision enables the processing of a large range of clinical questions. However, an important part of health information remains in Clinical Narratives and we are currently investigating novel approaches (deep learning) to enhance the semantic annotation of those unstructured data.
BibTeX:
@article{Lelong2019,
  author = {Lelong, Romain and Soualmia, Lina F and Grosjean, Julien and Taalba, Mehdi and Darmoni, SJ},
  title = {Building a {Semantic} {Health} {Data} {Warehouse}: {Evaluation} of a search tool in {Clinical} trials},
  journal = {JMIR Medical Informatics},
  year = {2019},
  pages = {30},
  doi = {10.2196/13917}
}

BibTeX:
@article{Maquet2019,
  author = {Maquet, C. and Evrard, M. and Kerbrat, J.-B. and Bastien, A.-V. and Adnot, J. and Trost, O.},
  title = {A case of severe facial palsy following bimaxillary osteotomy: It is time to update the pre-surgery patient fact sheet},
  month = {September},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  doi = {10.1016/j.jormas.2019.08.013}
}

Abstract: BACKGROUND: Despite growing access to effective therapies, asthma control still needs improvement. Many non-drug factors, such as allergens, air pollutants and stress also affect asthma control and patient quality of life, but an overview of the effectiveness of non-drug interventions on asthma control was lacking.
OBJECTIVES: To identify non-drug interventions likely to improve asthma control.
METHODS: A systematic review of the available literature in Medline and the Cochrane Library was conducted in March 2017, without any time limit. Initial searching identified 884 potentially relevant clinical trial reports, literature reviews and meta-analyses, which were screened for inclusion using criteria of quality, relevance, and reporting outcomes based on asthma control.
RESULTS: Eighty-two publications met the inclusion criteria. In general, the quality of the studies was low. Patient education programmes (22 studies) significantly improved asthma control. Multifaceted interventions (10 studies), which combined patient education programmes with decreasing exposure to indoor allergens and pollutants, significantly improved asthma control based on clinically relevant outcomes. Renovating homes to reduce exposure to allergens and indoor pollutants improved control (two studies). Air filtration systems (five studies) were effective, especially in children exposed to second-hand smoke. Most measures attempting to reduce exposure to dust mites were ineffective (five studies). Dietary interventions (eight studies) were ineffective. Promoting physical activity (five studies) tended to yield positive results, but the results did not attain significance.
CONCLUSION: Twenty-six interventions were effective in asthma control. Simultaneously combining several action plans, each focusing on different aspects of asthma management, seems most likely to be effective.
BibTeX:
@article{Schuers2019,
  author = {Schuers, Matthieu and Chapron, Anthony and Guihard, Hugo and Bouchez, Tiphanie and Darmon, David},
  title = {Impact of non-drug therapies on asthma control: {A} systematic review of the literature},
  month = {March},
  journal = {The European Journal of General Practice},
  year = {2019},
  pages = {1--12},
  doi = {10.1080/13814788.2019.1574742}
}

Abstract: INTRODUCTION:
Research in family medicine is necessary to improve the quality of care. The number of publications in general medicine remains low. Databases from Electronic Medical Records can increase the number of these publications. These data must be coded to be used pertinently. The objective of this study was to assess the quality of semantic annotation by a multi-terminological concept extractor within a corpus of family medicine consultations.
METHOD:
Consultation data in French from 25 general practitioners were automatically annotated using 28 different terminologies. The data extracted were classified into three groups: reasons for consulting, observations and consultation results. The first evaluation led to a correction phase of the tool which led to a second evaluation. For each evaluation, the precision, recall and F-measure were quantified. Then, the inter- and intra-terminological coverage of each terminology was assessed.
RESULTS:
Nearly 15,000 automatic annotations were manually evaluated. The mean values for the second evaluation of precision, recall and F-measure were 0.85, 0.83 and 0.84 respectively. The most common terminologies used were SNOMED CT, SNOMED 3.5 and NClt. The terminologies with the best intra-terminological coverage were ICPC-2, DRC and CISMeF Meta-Terms.
CONCLUSION:
A multi-terminological concepts extractor can be used for the automatic annotation of consultation data in family medicine. Integrating such a tool into general practitioners' business software would be a solution to the lack of routine coding. Developing the use of a single terminology specific to family medicine could improve coding, facilitate semantic interoperability and the communication of relevant information.
BibTeX:
@article{Siefridt2019,
  author = {Charlotte Siefridt and Julien Grosjean and Tatiana Lefebvre and Laetitia Rollin and Stéfan Darmoni and Matthieu Schuers},
  title = {Evaluation of automatic annotation by a multi-terminological concepts extractor within a corpus of data from family medicine consultations},
  journal = {International Journal of Medical Informatics},
  year = {2019},
  doi = {10.1016/j.ijmedinf.2019.104009}
}

Abstract: Résumé
Les médecins du travail évoquent souvent des difficultés à réaliser du maintien dans l’emploi pour les salariés vus en visite de pré-reprise en fin d’indemnisation par l’assurance maladie, le recours à l’inaptitude étant souvent inévitable. L’objectif de l’étude était d’étudier le devenir des salariés, notamment l’impact sur le contrat de travail en fonction d’une notification de fin d’indemnisation journalière (IJ) préalable à la réalisation de la visite de pré-reprise (VPR) mais également renseigner les délais de réalisation des différentes étapes du processus de maintien.
Méthode
Dans cette étude descriptive transversale, durant 6 mois en 2016–2017, pour les salariés adressés en visite de pré-reprise par le médecin conseil de l’assurance maladie, les médecins du travail de Haute Normandie ont été invités à compléter un questionnaire retraçant le parcours de maintien en emploi du salarié, l’avis du médecin du travail sur la possibilité de maintien en emploi et le devenir du contrat de travail.
Résultats
Parmi les visites de pré-reprise réalisées (n=641), 40 % (n=255) d’entre elles faisaient l’objet d’une notification de fin d’IJ lors de leur réalisation et 65 % (n=415) comportaient un avis du médecin du travail sur la possibilité de maintien dans l’emploi. La proportion de salariés pouvant être maintenue au travail selon le médecin du travail était de 52 %. Elle était significativement moins importante dans le groupe ayant eu une notification de fin d’indemnités journalières que dans le groupe n’en ayant pas eu (36 % vs 70  p=0,001).
Conclusion
Cette étude démontre bien l’intérêt de la coordination des acteurs en terme de maintien dans l’emploi, notamment au niveau médical. Elle invite les différents acteurs à prendre le temps nécessaire, afin de prévenir la désinsertion professionnelle.
Summary
Occupational health physicians often describe return to work difficulties for patients having notification of end of indemnisation of sick leave by health insurance. The aim of the study was to assess the professional employees becoming, especially consequence on the working contract, according to notification of end of indemnisation of sick leave by health insurance, and to describe delays of the different return to work steps.
Methods
In this descriptive transversal study, during 6 months in 2016–2017, Upper Normandy's occupational physicians completed a questionnaire for employees in sick leave who where addressed by the insurance health physician. Questions were about possibility of return to work according to the occupational physician, return to work process and the evolution of the work contract.
Results
On 641 return to work consultations, 40% (n=255) had notification of end of indemnisation of sick leave by health insurance and 65% (n=415) mentioned the occupational health physician opinion about the possibility of return to work. Occupational health physician declared possibility for return to work for 52% of employees. This proportion was significantly lower for employees who had a notification of end of indemnisation of sick leave by health insurance. (36% vs. 70 P=0.001).
Conclusion
Coordination between return to work professionnals, particularly occupational health physicians and insurance health physicians is an important factor to improve employees’ return to work.
BibTeX:
@article{Courtois2019,
  author = {Courtois, R. and Lefebvre, A. and Gehanno, J. -F. and Rollin, L.},
  title = {La visite de pré-reprise avec notification de fin d’indemnités journalières : un facteur défavorable au maintien dans l’emploi ?},
  month = {April},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2019},
  volume = {80},
  number = {2},
  pages = {108--114},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878518308038},
  doi = {10.1016/j.admp.2018.11.004}
}

BibTeX:
@article{Desbarats2019,
  author = {Desbarats, C. and Adnot, J. and Bastien, A. V. and Trost, O.},
  title = {Histiocytose langerhansienne révélée par un désordre de l’appareil manducateur : rapport d’un cas et revue de la littérature des atteintes crâniofaciales.},
  month = {August},
  journal = {La Revue de médecine interne},
  year = {2019},
  url = {https://www.lissa.fr/fr/rep/articles/31474430},
  doi = {10.1016/j.revmed.2019.08.005}
}

Abstract: Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevention mostly relies on mechanical protection (clothes covering most parts of the body) that may be completed by chemical protection (repulsives). Secondary prevention relies on early detection of ticks after exposure, and mechanical extraction. There is currently no situation in France when prophylactic antibiotics would be recommended. The incidence of Lyme borreliosis in France, estimated through a network of general practitioners (réseau Sentinelles), and nationwide coding system for hospital stays, has not significantly changed between 2009 and 2017, with a mean incidence estimated at 53 cases/100,000 inhabitants/year, leading to 1.3 hospital admission/100,000 inhabitants/year. Other tick-borne diseases are much more seldom in France: tick-borne encephalitis (around 20 cases/year), spotted-fever rickettsiosis (primarily mediterranean spotted fever, around 10 cases/year), tularemia (50-100 cases/year, of which 20% are transmitted by ticks), human granulocytic anaplasmosis (<10 cases/year), and babesiosis (<5 cases/year). The main circumstances of diagnosis for Lyme borreliosis are cutaneous manifestations (primarily erythema migrans, much more rarely borrelial lymphocytoma and atrophic chronic acrodermatitis), neurological (<15% of cases, mostly meningoradiculitis and cranial nerve palsy, especially facial nerve) and rheumatologic (mostly knee monoarthritis, with recurrences). Cardiac and ophtalmologic manifestations are very rarely encountered.
BibTeX:
@article{Figoni2019,
  author = {Figoni, J. and Chirouze, C. and Hansmann, Y. and Lemogne, C. and Hentgen, V. and Saunier, A. and Bouiller, K. and Gehanno, J. F. and Rabaud, C. and Perrot, S. and Caumes, E. and Eldin, C. and de Broucker, T. and Jaulhac, B. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Gocko, X. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J. P. and Degeilh, B. and Partouche, H. and Lenormand, C. and Sotto, A. and Raffetin, A. and Monsuez, J. J. and Michel, C. and Boulanger, N. and Cathebras, P. and Tattevin, P. and endorsed by scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {318--334},
  doi = {10.1016/j.medmal.2019.04.381}
}

Abstract: BACKGROUND: In France, complex cases of occupational disease (OD) are submitted to regional committees who are in charge of accepting, or rejecting, the claim. Their mean annual acceptance rate varies from one region to another, which may reflect differences in the cases, or discrepancies between committees. The objective of this study was to assess the comparability of the decisions of the committees on the basis of standardized cases.
METHODS: Three experienced occupational physicians specialized in OD were asked to develop 28 clinical cases representative of claims for compensation usually seen in these committees. The cases, in the form of short vignettes, were submitted to the 18 French regional committees, asking if they would recognise each case as an OD.
RESULTS: All committees participated. The acceptance rate (recognition of the case as an OD) varied, ranging from 18% to 70%. All the committees took the same decision for only 7 out of the 28 cases, but half accepted and half refused for 3 cases. For 10 cases, one quarter of the committees gave a decision different than the other 75%. The highest discordance rates were observed for the cases concerning musculoskeletal disorders and asbestos related diseases.
CONCLUSION: The committees take very different decisions in terms of recognition of OD, especially for the most frequently compensated OD in France, i.e. musculoskeletal disorders and asbestos related diseases. This is a major source of injustice for the employees who seek compensation and there is a need to develop methods to harmonize decisions between committees.
BibTeX:
@article{Gehanno2019b,
  author = {Gehanno, J.-F. and Letalon, S. and Gislard, A. and Rollin, L.},
  title = {Inequities in occupational diseases recognition in {France}},
  month = {July},
  journal = {Revue D'epidemiologie Et De Sante Publique},
  year = {2019},
  volume = {67},
  number = {4},
  pages = {247--252},
  doi = {10.1016/j.respe.2019.04.054}
}

BibTeX:
@article{Gocko2019,
  author = {Gocko, X. and Lenormand, C. and Lemogne, C. and Bouiller, K. and Gehanno, J.-F. and Rabaud, C. and Perrot, S. and Eldin, C. and de Broucker, T. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Sobas, C. and Jaulhac, B. and Figoni, J. and Chirouze, C. and Hansmann, Y. and Hentgen, V. and Caumes, E. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J.-P. and Degeilh, B. and Partouche, H. and Saunier, A. and Sotto, A. and Raffetin, A. and Monsuez, J.-J. and Michel, C. and Boulanger, N. and Cathebras, P. and Tattevin, P. and endorsed by the following scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {296--317},
  doi = {10.1016/j.medmal.2019.05.006}
}

Abstract: The serodiagnosis of Lyme borreliosis is based on a two-tier strategy: a screening test using an immunoenzymatic technique (ELISA), followed if positive by a confirmatory test with a western blot technique for its better specificity. Lyme serology has poor sensitivity (30-40%) for erythema migrans and should not be performed. The seroconversion occurs after approximately 6 weeks, with IgG detection (sensitivity and specificity both>90%). Serological follow-up is not recommended as therapeutic success is defined by clinical criteria only. For neuroborreliosis, it is recommended to simultaneously perform ELISA tests in samples of blood and cerebrospinal fluid to test for intrathecal synthesis of Lyme antibodies. Given the continuum between early localized and disseminated borreliosis, and the efficacy of doxycycline for the treatment of neuroborreliosis, doxycycline is preferred as the first-line regimen of erythema migrans (duration, 14 days; alternative: amoxicillin) and neuroborreliosis (duration, 14 days if early, 21 days if late; alternative: ceftriaxone). Treatment of articular manifestations of Lyme borreliosis is based on doxycycline, ceftriaxone, or amoxicillin for 28 days. Patients with persistent symptoms after appropriate treatment of Lyme borreliosis should not be prescribed repeated or prolonged antibacterial treatment. Some patients present with persistent and pleomorphic symptoms after documented or suspected Lyme borreliosis. Another condition is eventually diagnosed in 80% of them.
BibTeX:
@article{Jaulhac2019,
  author = {Jaulhac, B. and Saunier, A. and Caumes, E. and Bouiller, K. and Gehanno, J. F. and Rabaud, C. and Perrot, S. and Eldin, C. and de Broucker, T. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Sobas, C. and Gocko, X. and Figoni, J. and Chirouze, C. and Hansmann, Y. and Hentgen, V. and Cathebras, P. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J. P. and Degeilh, B. and Partouche, H. and Lenormand, C. and Sotto, A. and Raffetin, A. and Monsuez, J. J. and Michel, C. and Boulanger, N. and Lemogne, C. and Tattevin, P. and endorsed by scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies (II). Biological diagnosis, treatment, persistent symptoms after documented or suspected Lyme borreliosis},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {335--346},
  doi = {10.1016/j.medmal.2019.05.001}
}

Abstract: Objectifs : L’objectif principal de cette étude était de décrire la méthodologie de redressement utilisée dans le cadre de l’observatoire « Évolution et relations en santé au travail » (Évrest). Les objectifs secondaires étaient, d’une part, d’apprécier l’ampleur des écarts entre les estimations brutes et pondérées et, d’autre part, de vérifier que le décalage de deux années dans la disponibilité des données de référence utilisées n’impactait pas substantiellement les estimations produites.
Méthodes : L’étude a porté sur les données recueillies en 2013 et 2014 (n = 26 227). Le redressement a comporté deux étapes : 1) la prise en compte de la probabilité de participation de chaque salarié ; 2) le calage sur marges pour corriger les éventuelles distorsions de l’échantillon par rapport au champ de l’enquête, les données de référence utilisées provenant des déclarations annuelles de données sociales (DADS) des années 2014 et 2012. L’impact du redressement a été analysé sur les 60 variables du questionnaire par l’étude des écarts entre les pourcentages bruts et pondérés.
Résultats : Au total, 90 % des écarts observés entre estimations brutes et pondérées étaient compris entre – 2,0 % et + 2,0 % avec les DADS 2014, 83 % avec les DADS 2012. L’estimation brute la plus surestimée concernait le travail à temps plein et celle la plus sous-estimée, le contact avec le public. L’impact d’un décalage de deux années des données de référence était faible, quelle que soit la variable étudiée.
Conclusion : Une méthodologie de redressement pour l’observatoire Évrest a été définie et mise en œuvre, permettant d’extrapoler les résultats à l’ensemble des salariés du champ de l’enquête.
BibTeX:
@article{Leroyer2019,
  author = {Leroyer, Ariane and Murcia, Marie and Chastang, Jean-François and Rollin, Laétitia and Volkoff, Serge and Molinié, Anne-Françoise and Niedhammer, Isabelle},
  title = {Méthodologie de redressement des données nationales de l’enquête Évrest},
  journal = {Sante Publique},
  year = {2019},
  volume = {Vol. 31},
  number = {5},
  pages = {645--655},
  url = {https://www.cairn.info/revue-sante-publique-2019-5-page-645.htm},
  doi = {10.3917/spub.195.0645}
}

Abstract: Compensation for occupational pulmonary diseases requires the establishment of guidelines based on standardized and objective criteria, in order to provide compensation that is as fair as possible to patients who suffer from them. A review of the elements necessary for the examination of an individual file was carried out by a working group. It is accepted that respiratory functional exploration is the key element in assessing the level of permanent disability in all of these conditions, with the exception of thoracic malignancies. Guiding scales have been developed for the respiratory impairment of three types of conditions: occupational asthma, thoracic malignancy, and other respiratory diseases. Additional criteria for increasing the permanent disability level are also proposed in order to take into account professional prejudice, in particular the possibility or not of continuing the occupational activity, in the same job or after changing to another. For certain respiratory diseases, a periodic reassessment of the initially attributed permanent disability level is recommended as well as the initial one at the time of definitive cessation of occupational activity.
BibTeX:
@article{Pairon2019,
  author = {Pairon, J.-C. and Azoury, H. and Catto, M. and Dalphin, J.-C. and Gehanno, J.-F. and Housset, B. and L'huillier, J.-P. and Serveau, S. and Straus, C.},
  title = {Comment évaluer en 2019 les taux d’incapacité permanente des pathologies professionnelles pulmonaires ?},
  month = {March},
  journal = {Revue Des Maladies Respiratoires},
  year = {2019},
  volume = {36},
  number = {3},
  pages = {307--325},
  doi = {10.1016/j.rmr.2018.07.007}
}

Abstract: OBJECTIVES: To conduct an audit of vaccination practices against pertussis in maternity wards to assess immunization practices targeting women, knowledge and awareness among health professionals and their involvement in the vaccination process, and to estimate their vaccine coverage. MATERIALS AND METHODS: 2017 cross-sectional descriptive survey using a data collection sheet of immunization practices targeting women and an anonymous questionnaire for health professionals whose vaccine coverage had been documented by the occupational health service. RESULTS: Five public maternity wards participated: one had a vaccination policy for women; 426 of 822 health professionals completed the questionnaire, 76% (from 50% of all residents to 83% of nurses) declared their vaccination status as up to date. Staff files in occupational health services showed that 69% of 822 health professionals received at least one vaccine booster during adulthood (57% less than 10 years before the survey); documented vaccination coverage rates ranged from 75% for residents to 91% for senior physicians. Occupational physicians and family physicians respectively performed 41% and 34% of vaccinations. While knowledge regarding vaccines was good, only 47% of health professionals declared prescribing them and 18% declared administering the anti-pertussis vaccine "often" or "very often". CONCLUSIONS: Updated data is needed to confirm the reported increase as participating centers are not representative of all birth centers. The active role of health professionals in vaccination-based pertussis prevention needs to be reinforced.
BibTeX:
@article{Pellissier2019,
  author = {Pellissier, G. and Lolom, I. and Cairati, N. and Cherifi, C. and Amiel-Taieb, C. and Farbos, S. and Caillaud, V. and Gaudelus, J. and Gozlan, C. and Pinquier, D. and Gehanno, J. F. and Luton, D. and Bouvet, E. and Abiteboul, D.},
  title = {Maternity staff immunization coverage against pertussis and maternal vaccination practices: Results of a 2017 cross-sectional survey in five public maternity hospitals},
  month = {July},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  doi = {10.1016/j.medmal.2019.07.009}
}

Abstract: Return to work is a public health priority which led the French Health Authority to publish recommendations about "return to work and health: prevention of exclusion from work". The aim of this article is to present a literature review of return to work after cancer. Studies about medium-term and long-term effects of cancer are sparse. They suggest worker durable effects. Factors associated with return to work are linked to the patient characteristics, to characteristics of the illness and the treatment, to the workplace and to the help provided to the patient during the return to work process. A specific plan for returning to work in 3 phases (situation comprehension, identification of negative and positive factors for returning to work, implementation of measures concerning the patient, the workplace and the coordination between return to work actors) should be built for each patient, involving the worker, the occupational practitioner, the general and specialist practitioners.
BibTeX:
@article{Rollin2019a,
  author = {Rollin, Laétitia and Fantoni-Quinton, Sophie and Petit, Audrey and Baumann, Camille and Petitprez, Karine and Gehanno, Jean-François and Fassier, Jean-Baptiste},
  title = {Maintien en emploi des patients atteints de cancer},
  month = {November},
  journal = {Bulletin Du Cancer},
  year = {2019},
  volume = {106},
  number = {11},
  pages = {1039--1049},
  doi = {10.1016/j.bulcan.2019.08.008}
}

Abstract: Résumé
Introduction
Les travailleurs du nucléaire peuvent être exposés à la contamination interne par des particules chaudes (particules insolubles radioactives d’un diamètre variant de 10 micromètres à 1 millimètre). Actuellement, aucun modèle biocinétique théorique décrivant l’évolution d’une telle contamination n’a été décrit par la Commission internationale de protection radiologique. L’objectif de ce travail était d’évaluer une nouvelle méthode pour estimer l’activité d’une particule chaude dans l’organisme.
Méthode
Plusieurs mesures anthropogammamétriques ont été réalisées à l’aide d’un fantôme anthropomorphe dénommé « Igor » dans lequel une source radioactive d’activité connue a été insérée. Igor est constitué de briques élémentaires permettant de simuler différentes localisations d’une particule chaude au sein de l’abdomen. Ces différentes mesures ont permis d’établir un facteur correctif à l’activité mesurée pour chaque localisation de la source. Afin de déterminer la position de la particule chaude dans l’abdomen du travailleur, deux examens anthropogammamétriques successifs lui sont réalisés (face puis dos). Le facteur correctif correspondant à la position estimée est ensuite appliqué à l’activité mesurée. Cette méthode a ensuite été utilisée dans un cas réel de contamination interne, en complément des examens radiotoxicologiques des selles.
Résultats
Au total, 24 mesures ont été réalisées pour tenir compte des différentes localisations de la particule chaude dans l’abdomen, du poids du sujet (70–90kg) et du type de radionucléide impliqué. Les facteurs correctifs étaient de 0,68–0,84 (source antérieure) et 1,78–2,09 (source postérieure) en configuration 70kg et de 0,95–1,43 et 2,24–3,15 en configuration 90kg. L’application de cette méthode a un cas réel de contamination interne a permis d’estimer l’activité d’une particule chaude entre 76 800 et 90 250 Becquerel. L’activité éliminée dans les selles était de 82 523 Becquerel.
Conclusion
Cette nouvelle méthode permet d’estimer plus rapidement l’activité réelle d’une particule chaude et pourrait être un outil complémentaire à la réalisation des examens radiotoxicologiques des selles dont l’observance est parfois imparfaite.
Summary
Purpose of the study
Nuclear power plants workers can be exposed to internal contamination via hot particles (radioactive insoluble particles with a 10 micrometers to 1 millimeter wide diameter). At present, no theoretical biokinetic model describing the contamination by these particles has been designed by the International Commission on Radiological Protection. The objective of this work was to describe a new method to estimate the activity of a hot particle in the body.
Method
Several whole-body measurements were realized using an anthropomorphic ghost called “Igor” into which a radioactive source of known activity was inserted. Igor is constituted with elementary bricks allowing to feign the various locations of a hot particle within the abdomen. These various measures allowed to establish a corrective factor in the activity measured for every location of the source. To determine the position of the hot particle in the worker abdomen, two whole-body measures were successively realized (face then back). The corrective factor corresponding to the estimated position is then applied to the moderate activity. This method was then used in a real case of internal contamination, in parallel faeces analysis were realized.
Results
In total, 24 measures were realized to consider various locations of the hot particle in the abdomen, the weight of the subject (70–90kg) and the type of radionuclides involved. The corrective factor was 0.68–0.84 (source front) and 1.78–2.09 (source posterior) in configuration 70kg and of 0.95–1.43 and 2.24–3.15 for 90kg. The application of this method in a real case of internal contamination allowed to estimate the activity of a hot particle between 76,800 and 90,250 Becquerel. The real activity according to the faecal examinations was 82,523 Becquerel.
Conclusion
This new method allows to estimate more quickly the real activity of a hot particle and could be a complementary tool to faeces analysis as collecting is sometimes troublesome.
BibTeX:
@article{Sailly2019,
  author = {Sailly, M. and Le-Couteulx, I. and Bocquet, I. and Gehanno, J. F. and Rollin, L.},
  title = {Travailleur du nucléaire : activité d’une particule chaude incorporée},
  month = {February},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2019},
  volume = {80},
  number = {1},
  pages = {39--46},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878518308051},
  doi = {10.1016/j.admp.2018.10.009}
}

Abstract: Even if, English is generally used for international communication, it is essential to keep in mind that research is running at the local level by local teams generally communicating in their local/national language. Bearing these in mind, the "European Federation for Medical Informatics Working Group on Health Informatics for Inter-regional Cooperation" has as one of its objectives, to develop a multilingual dictionary focusing on Health Informatics as a collaboration tool allowing improving international and more particularly European cooperation. This dictionary is implemented as a part of HeTOP (Health Terminology/Ontology Portal) which is currently integrating more than 70 terminologies and ontologies in 32 languages. The EFMI Dictionary main aims are helping medical librarians, translators, academic and industrial researchers understanding better one another and supporting students self-learning.
BibTeX:
@inproceedings{Benis2019,
  author = {Benis, Arriel and Crisan-Vida, Mihaela and Stoicu-Tivadar, Lacramioara and Darmoni, Stefan},
  title = {A {Multi}-{Lingual} {Dictionary} for {Health} {Informatics} as an {International} {Cooperation} {Pillar}.},
  booktitle = {ICIMTH 2019, the 17th International Conference on Informatics, Management and Technology in Healthcare},
  month = {July},
  journal = {Studies in health technology and informatics},
  year = {2019},
  volume = {262},
  pages = {31--34},
  doi = {10.3233/SHTI190009}
}

Abstract: The ApiAppS ongoing project aims to provide physicians with a decision support system for the prescription / recommendation of mHealth technologies. We describe the context and the components of the project which includes: 1) a technical part on modelling and implementing the decision support system, and 2) a psychosocial investigation part designed to have a better knowledge of general practitioners (GPs) and patients' expectations, beliefs and practices.
BibTeX:
@inproceedings{Dufour2019,
  author = {Dufour, Jean-Charles and Grosjean, Julien and Darmoni, Stefan and Yasini, Mobin and Marchand, Guillaume and Simon, Christian and Sarradon-Eck, Aline and Préau, Marie and Darmon, David and Schuers, Matthieu and Hassanaly, Parina and Giorgi, Roch},
  title = {{ApiAppS}: {A} {Project} to {Study} and {Help} {Practitioners} in {Recommending} {mHealth} {Apps} and {Devices} to {Their} {Patients}},
  booktitle = {MEDINFO 2019: Health and Wellbeing e-Networks for All},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2019},
  volume = {264},
  pages = {1919--1920},
  doi = {10.3233/SHTI190713}
}

Abstract: Structuring raw medical documents with ontology mapping is now the next step for medical intelligence. Deep learning models take as input mathematically embedded information, such as encoded texts. To do so, word embedding methods can represent every word from a text as a fixed-length vector. A formal evaluation of three word embedding methods has been performed on raw medical documents. The data corresponds to more than 12M diverse documents produced in the Rouen hospital (drug prescriptions, discharge and surgery summaries, inter-services letters, etc.). Automatic and manual validation demonstrates that Word2Vec based on the skip-gram architecture had the best rate on three out of four accuracy tests. This model will now be used as the first layer of an AI-based semantic annotator.
BibTeX:
@inproceedings{Dynomant2019a,
  author = {Dynomant, Emeric and Lelong, Romain and Dahamna, Badisse and Massonnaud, Clément and Kerdelhué, Gaëtan and Grosjean, Julien and Canu, Stéphane and Darmoni, Stéfan},
  title = {Word {Embedding} for {French} {Natural} {Language} in {Healthcare}: {A} {Comparative} {Study}},
  booktitle = {MEDINFO 2019: Health and Wellbeing e-Networks for All},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2019},
  volume = {264},
  pages = {118--122},
  doi = {10.3233/SHTI190195}
}

Abstract: Information science is a fast-changing field, and medical librarians need to develop their roles to meet the users’new requirements. The professional development becomes a major challenge, not only regarding the core activities, but also in the way librarians and users can learn in a more innovative way. In order to invent new tools for training, a group of librarians with different backgrounds decided to create a game inspired by the “Bucket ofdoom”, which is described as a “Card game that meets storytelling with a sprinkling of comedy”. This adapted version for health libraries will face players with real professional situations. To overcome each challenge and have fun, librarians must use their experience and imagination with a high dose of creativity and humour.
BibTeX:
@article{Gomez-Sanchez2019,
  author = {Alicia Gómez-Sánchez and Gaétan Kerdelhue and Rebeca Isabel-Gómez and Mar González-Cantalejo and Pablo Iriarte and Floriane Muller},
  title = {Health libraries: sharing through gaming},
  month = {September},
  journal = {Journal of EAHIL},
  year = {2019},
  volume = {15},
  number = {3},
  pages = {8-11},
  url = {http://ojs.eahil.eu/ojs/index.php/JEAHIL/article/view/329},
  doi = {10.32384/jeahil15329}
}

Abstract: Il n’existe pas de standard universellement accepté pour nommer les médicaments. L’identification du médicament a fait l’objet de nombreux travaux de normalisation. Notre objectif est de définir un modèle formel du médicament en français pour lier les différentes entités manipulables autour du médicament. Ce modèle formel vise un double sous-objectif : (a) créer et instancier une ontologie formelle du médicament ; (b) créer une terminologie du médicament, intégrable dans un serveur de terminologies. À terme, ces ressources seront des outils puissants pour, notamment, supporter la recherche d’information dans des bases de médicaments ou des entrepôts de données. Ils seront mis librement à disposition de la communauté.
BibTeX:
@inproceedings{Grosjean2019,
  author = {Julien Grosjean and Catherine Letord and Jean Charlet and Xavier Aimé and Loane Danès and Julien Rio and Ilan Zana and Stéfan J Darmoni and Catherine Duclos},
  title = {Un modèle sémantique d’identification du médicament en France},
  booktitle = {Atelier IA \& Santé},
  address = {Toulouse},
  month = {Juillet},
  year = {2019}
}

Abstract: Introduction
Les technologies de l’information et de la communication ont permis la naissance du web 2.0, caractérisé par la mise en place et l’utilisation de nouveaux outils collaboratifs de communication tels que les blogs, les wikis, les fils RSS et les réseaux sociaux. En s’appropriant ces outils, une médecine participative basée sur le partage d’informations et d’expériences entre professionnels, patients et tout acteur de la santé s’est développée. Depuis juin 2012, une communauté médicale échange sur Twitter avec le hashtag DocTocToc et contribue à la naissance de la e-santé sur ce réseau social. L’objectif de cette étude est d’analyser les principales thématiques des demandes effectuées via le hashtag DocTocToc par les médecins généralistes entre juin 2012 et mars 2017.
Méthodes
Une collecte de données par une méthode de « web scraping » a permis de constituer un corpus de tweets dont les auteurs ont été identifiés manuellement afin de procéder à un échantillonnage, de façon à ne conserver que les tweets émis par les médecins généralistes. Une étape de prétraitement a permis de transformer les formes potentiellement non reconnues par les logiciels de traitement du langage naturel. Le corpus a été appréhendé à l’aide de deux approches : une approche lexicale via le logiciel Iramuteq® et une indexation terminologique par l’extracteur de concepts multi-terminologiques (ECMT) du Catalogue et index des sites médicaux francophones (CISMeF).
Résultats
Sur les 12 716 tweets recueillis, 7366 étaient rédigés par des médecins généralistes et ont été analysés. L’approche lexicale détermine deux grands mondes lexicaux représentés sous forme de dendrogramme, l’un en lien avec les demandes médico administratives relatives à la gestion du cabinet et à la prise en charge sociale du patient, l’autre en lien avec les demandes d’ordre purement médicales. La méthode d’indexation terminologique met en évidence les spécialités médicales pourvoyeuses de demandes de télé-expertise : gynécologie, neurologie, infectiologie, pédiatrie, cardiologie, dermatologie ; et permet de les croiser avec l’objectif de la demande : diagnostic, thérapeutique.
Conclusion
Sur Twitter®, le hashtag DocTocToc est utilisé par les médecins généralistes comme un espace de partage informel d’informations en matière de santé mais aussi de gestion de problèmes administratifs et sociaux. Le DocsTocToc se présente comme un groupe d’échange de pratique à grande échelle ou le médecin compte sur l’avis de ses pairs.(Fig. 1)
BibTeX:
@article{Salles2019,
  author = {Salles, A. and Dufour, J. and Hassanaly, P. and Michel, P. and Cabot, C. and Grosjean, J.},
  title = {Analyse du discours médical sur {Twitter}®. Étude d’un corpus de tweets émis par des médecins généralistes entre juin 2012 et mars 2017 et contenant le hashtag \#{DocTocToc}},
  month = {May},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2019},
  series = {{EPICLIN} 2019},
  volume = {67},
  pages = {S152--S153},
  url = {http://www.sciencedirect.com/science/article/pii/S0398762019301993},
  doi = {10.1016/j.respe.2019.03.027}
}

Abstract: Introduction
Les établissements de santé sont tenus d’assurer la traçabilité des dispositifs médicaux (DM). À l’enjeu sanitaire sous la responsabilité de la pharmacie, s’ajoute un enjeu financier concernant les DM de la liste en sus. Devant l’absence à ce jour d’une base d’associations exhaustives de tous les DM Cladimed et des actes médicaux de la Classification commune des actes médicaux (CCAM), le CHU de Rouen a débuté ce projet.
Méthodes
Sur la base des activités du Programme de médicalisation du système d’information (PMSI) de l’activité Médecine, chirurgie et obstétrique (MCO) 2016 et 2017 du CHU de Rouen, l’ensemble des cooccurrences entre les actes CCAM et les codes Cladimed des DM (sur la liste en sus ou non) ont été identifiées de manière automatisée. Ensuite, dans le domaine de la cardiologie interventionnelle, une validation experte a été réalisée. Enfin, cette base préliminaire a été implémentée sur l’activité MCO de janvier à septembre 2018 de notre établissement, grâce à un outil écrit en Python, afin de l’évaluer.
Résultats
Sur les 113 284 RSS analysés, seuls 768 comportaient des actes de cardiologie interventionnelle ; 24 % de ces séjours comportaient au moins une erreur avérée : 5 % codes actes CCAM erronés et/ou oubli de traçabilité de DM en SUS, 10 % de nouvelles activités médicales et/ou nouveaux codes Cladimed 2018, 20 % erreurs de quantité de DM et 16 % incohérence qualitative d’association de DM. Cependant, 48 % des erreurs initiales pointaient des limites de paramétrage de notre programme.
Discussion/Conclusion
Ces résultats préliminaires montrent ainsi la possibilité d’améliorer la qualité du codage des actes CCAM et la traçabilité sanitaire de tous les DM. En effet, cet outil permettrait un contrôle a posteriori renforcé pour les services d’information médicale et de pharmacie. Des mises à jour seront évidemment nécessaires des classifications CCAM et Cladimed et des associations dans notre base. Par ailleurs, l’élargissement progressif de notre base d’associations à toutes les autres spécialités est notre ultime objectif.
BibTeX:
@article{Ndangang2019,
  author = {Ndangang, M. and Aussy, K. and Grosjean, J. and Tanguy, L.},
  title = {Intérêt d’une base d’associations exhaustives d’actes de la classification commune des actes médicaux et de dispositifs médicaux : un projet en cours au {CHU} de {Rouen}, {France}},
  month = {March},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2019},
  series = {{IIe} {Congrès} national {Emois} {Colloque} organisé par l’{Association} {Evaluation}, management, organisation, santé ({Emois}) {Livre} des résumés présentés au congrès},
  volume = {67},
  pages = {S112},
  url = {https://www.sciencedirect.com/science/article/pii/S0398762019301129},
  doi = {10.1016/j.respe.2019.01.111}
}

Abstract: PubMed is the biggest and most used bibliographic database worldwide, hosting more than 26M biomedical publications. One of its useful features is the "similar articles" section, allowing the end-user to find scientific articles linked to the consulted document in term of context. The aim of this study is to analyze whether it is possible to replace the statistic model PubMed Related Articles (pmra) with a document embedding method. Doc2Vec algorithm was used to train models allowing to vectorize documents. Six of its parameters were optimised by following a grid-search strategy to train more than 1,900 models. Parameters combination leading to the best accuracy was used to train models on abstracts from the PubMed database. Four evaluations tasks were defined to determine what does or does not influence the proximity between documents for both Doc2Vec and pmra. The two different Doc2Vec architectures have different abilities to link documents about a common context. The terminological indexing, words and stems contents of linked documents are highly similar between pmra and Doc2Vec PV-DBOW architecture. These algorithms are also more likely to bring closer documents having a similar size. In contrary, the manual evaluation shows much better results for the pmra algorithm. While the pmra algorithm links documents by explicitly using terminological indexing in its formula, Doc2Vec does not need a prior indexing. It can infer relations between documents sharing a similar indexing, without any knowledge about them, particularly regarding the PV-DBOW architecture. In contrary, the human evaluation, without any clear agreement between evaluators, implies future studies to better understand this difference between PV-DBOW and pmra algorithm.
BibTeX:
@article{Dynomant2019b,
  author = {Dynomant, Emeric and Darmoni, Stéfan J. and Lejeune, Émeline and Kerdelhué, Gaëtan and Leroy, Jean-Philippe and Lequertier, Vincent and Canu, Stéphane and Grosjean, Julien},
  title = {Doc2Vec on the {PubMed} corpus: study of a new approach to generate related articles},
  month = {November},
  journal = {arXiv:1911.11698 [cs]},
  year = {2019},
  note = {arXiv: 1911.11698},
  url = {http://arxiv.org/abs/1911.11698}
}

BibTeX:
@article{Trost2019,
  author = {Trost, Olivier and Micoud, Stéphane and Duparc, Fabrice},
  title = {Comments about the article "A Crouzon syndrome from the classic period of Maya civilization?" The art historian's point of view},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2019},
  volume = {41},
  number = {12},
  pages = {1529--1530},
  doi = {10.1007/s00276-019-02302-y}
}

Abstract: Les données cliniques sont produites par différents professionnels de santé, dans divers lieux et sous diverses formes dans le cadre de la pratique de la médecine. Elles présentent par conséquent une hétérogénéité à la fois au niveau de leur nature et de leur structure mais également une volumétrie particulièrement importante et qualifiable de massive. Le travail réalisé dans le cadre de cette thèse s’attache à proposer une méthode de recherche d’information efficace au sein de ce type de données complexes et massives. L’accès aux données cliniques se heurte en premier lieu à la nécessité de modéliser l’informationclinique. Ceci peut notamment être réalisé au sein du dossier patient informatisé ou, dans une plus large mesure, au sein d’entrepôts de données. Je propose dans ce mémoire unepreuve de concept d’un moteur de recherche permettant d’accéder à l’information contenue au sein de l’entrepôt de données de santé sémantique du Centre Hospitalier Universitaire de Rouen. Grâce à un modèle de données générique, cet entrepôt adopte une vision de l’information assimilable à un graphe de données rendant possible la modélisation de cette information tout en préservant sa complexité conceptuelle. Afin de fournir des fonctionnalités de recherche adaptées à cette représentation générique, un langage de requêtes permettant l’accès à l’information clinique par le biais des diverses entités qui la composent a été développé et implémenté dans le cadre de cette thèse. En second lieu, la massivité des données cliniques constitue un défi technique majeur entravant la mise en oeuvre d’une recherche d’information efficace. L’implémentation initiale de la preuve de concept sur un système de gestion de base de données relationnel a permis d’objectiver les limites de ces derniers en terme de performances. Une migration vers un système NoSQL orienté clé-valeur a été réalisée. Bien qu’offrant de bonnes performances d’accès atomique aux données, cette migration a également nécessité des développements annexes et la définition d’une architecture matérielle et applicative propice à la mise en oeuvre des fonctionnalités de recherche et d’accès aux données. Enfin, l’apport de ce travail dans le contexte plus général de l’entrepôt de données de santé sémantique du CHU de Rouen a été évalué. La preuve de concept proposée dans ce travail a ainsi été exploitée pour accéder aux descriptions sémantiques afin de répondre à des critères d’inclusion et d’exclusion de patients dans des études cliniques. Dans cette évaluation, une réponse totale ou partielle a pu être apportée à 72,97% des critères. De plus, la généricité de l’outil a également permis de l’exploiter dans d’autres contextes tels que la recherche d’information documentaire et bibliographique en santé.
BibTeX:
@phdthesis{Lelong2019a,
  author = {Romain Lelong},
  title = {Accès sémantique aux données massives et hétérogènes en santé},
  month = {June},
  school = {Normandie Université},
  year = {2019},
  url = {https://tel.archives-ouvertes.fr/tel-02287217}
}

2018


Abstract: INTRODUCTION: Oral metastases from hepatocellular carcinoma (HCC) are very rare, and predominate in the mandible. We report an exceptional case of maxillary metastasis revealing HCC. CASE REPORT: A 56-year-old man with a previous medical history of alcohol abuse presented to our department with a 3-week evolving oral mass. Physical examination showed a left maxillary tumor. The biopsy revealed a HCC and a multi-metastatic HCC with portal thrombosis and a pulmonary embolism was discovered following a CT-scan. A state of advanced malnutrition contraindicated sorafenib chemotherapy. Thus, external irradiation was proposed, without success. The patient subsequently died 50 days later. DISCUSSION: Maxillary HCC metastases are extremely rare. The average age of HCC jaw metastases appearance in patients has been reported to be approximately 57 years, men are more affected than women are, and the mean life expectancy is 12 months following the diagnosis. These patients require palliative treatment. Local recurrences occur very early after possible surgery, and expose the patient to life-threatening bleeding.
BibTeX:
@article{Adnot2018,
  author = {Adnot, J. and Gemival, P. and Trost, O.},
  title = {Maxillary metastasis from a hepatocellular carcinoma: Report of an uncommon presentation and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2018},
  volume = {119},
  number = {6},
  pages = {503--505},
  doi = {10.1016/j.jormas.2018.07.001}
}

Abstract: BACKGROUND: General practice became an academic discipline quite recently in many western countries. In France, junior lecturer work is specified in a three-part mandate: medical work in general practice, teaching in the university, and research. Since 2007, 130 junior lecturers have been appointed in general practice. The aim of the creation of junior lecturer status was to align general practice with other specialties and to develop research and education in primary care.
OBJECTIVES: To describe the healthcare, teaching and research undertaken by junior lecturers in general practice, practising in October 2014.
METHODS: A cross-sectional multicentre study using an online self-administered questionnaire on the cohort composed of all the junior lecturers in general practice with open questions and the qualitative analysis of written verbatim accounts.
RESULTS: Of the 95 junior lecturers practising at the date of the study, 75 (79 responded; average age 32 years; gender ratio (F/M) 2.4:1. They spent five, two and three half-days per week respectively in healthcare, teaching and research. The healthcare activity was predominantly carried out in the community (73. Thirty-nine per cent worked as part of a multi-professional team taking on 50 consultations per week. Most of the educational work involved lecturing and mentoring students specializing in general practice (median 86 hours per year). Research output increased during the fellowship. Research topics were varied and relevant to the disciplinary field.
CONCLUSION: During the fellowship, the balancing, and even the reinforcement, of healthcare and research contributions were accompanied by a significant investment in educational provision.
BibTeX:
@article{Barais2018,
  author = {Barais, Marie and Laporte, Catherine and Schuers, Matthieu and Saint-Lary, Olivier and Frappé, Paul and Dibao-Dina, Clarisse and Darmon, David and Bouchez, Tiphanie and Gelly, Julien},
  title = {Cross-sectional multicentre study on the cohort of all the {French} junior lecturers in general practice},
  month = {December},
  journal = {The European Journal of General Practice},
  year = {2018},
  volume = {24},
  number = {1},
  pages = {99--105},
  doi = {10.1080/13814788.2017.1422176}
}

Abstract: Background: The Food and Drug Administration (FDA) in the United States and the European Medicines Agency (EMA) have recognized social media as a new data source to strengthen their activities regarding drug safety. Objective: Our objective in the ADR-PRISM project was to provide text mining and visualization tools to explore a corpus of posts extracted from social media. We evaluated this approach on a corpus of 21 million posts from five patient forums, and conducted a qualitative analysis of the data available on methylphenidate in this corpus. Methods: We applied text mining methods based on named entity recognition and relation extraction in the corpus, followed by signal detection using proportional reporting ratio (PRR). We also used topic modelling based on the Correlated Topic Model to obtain the list of thematics in the corpus and classify the messages based on their topics. Results: We automatically identified 3443 posts about methylphenidate published between 2007 and 2016, among which 61 adverse drug reactions (ADR) were automatically detected. Two pharmacovigilance experts evaluated manually the quality of automatic identification, and a f-measure of 0.57 was reached. Patient’s reports were mainly neuro-psychiatric effects. Applying PRR, 67% of the ADRs were signals, including most of the neuro-psychiatric symptoms but also palpitations. Topic modelling showed that the most represented topics were related to Childhood and Treatment initiation, but also Side effects. Cases of misuse were also identified in this corpus, including recreational use and abuse. Conclusion: Named entity recognition combined with signal detection and topic modelling have demonstrated their complementarity in mining social media data. An in-depth analysis focused on methylphenidate showed that this approach was able to detect potential signals and to provide better understanding of patients’ behaviors regarding drugs, including misuse.
BibTeX:
@article{Chen2018,
  author = {Chen, Xiaoyi and Faviez, Carole and Schuck, Stéphane and Lillo-Le-Louët, Agnès and Texier, Nathalie and Dahamna, Badisse and Huot, Charles and Foulquié, Pierre and Pereira, Suzanne and Leroux, Vincent and Karapetiantz, Pierre and Guenegou-Arnoux, Armelle and Katsahian, Sandrine and Bousquet, Cédric and Burgun, Anita},
  title = {Mining Patients' Narratives in Social Media for Pharmacovigilance: Adverse Effects and Misuse of Methylphenidate},
  journal = {Frontiers in Pharmacology},
  year = {2018},
  volume = {9},
  url = {https://www.frontiersin.org/articles/10.3389/fphar.2018.00541/full},
  doi = {10.3389/fphar.2018.00541}
}

Abstract: BACKGROUND: While documentation of clinical aspects of General Practice/Family Medicine (GP/FM) is assured by the International Classification of Primary Care (ICPC), there is no taxonomy for the professional aspects (context and management) of GP/FM. OBJECTIVES: To present the development, dissemination, applications, and resulting face validity of the Q-Codes taxonomy specifically designed to describe contextual features of GP/FM, proposed as an extension to the ICPC. DEVELOPMENT: The Q-Codes taxonomy was developed from Lamberts' seminal idea for indexing contextual content (1987) by a multi-disciplinary team of knowledge engineers, linguists and general practitioners, through a qualitative and iterative analysis of 1702 abstracts from six GP/FM conferences using Atlas.ti software. A total of 182 concepts, called Q-Codes, representing professional aspects of GP/FM were identified and organized in a taxonomy. Dissemination: The taxonomy is published as an online terminological resource, using semantic web techniques and web ontology language (OWL) ( http://www.hetop.eu/Q ). Each Q-Code is identified with a unique resource identifier (URI), and provided with preferred terms, and scope notes in ten languages (Portuguese, Spanish, English, French, Dutch, Korean, Vietnamese, Turkish, Georgian, German) and search filters for MEDLINE and web searches. APPLICATIONS: This taxonomy has already been used to support queries in bibliographic databases (e.g., MEDLINE), to facilitate indexing of grey literature in GP/FM as congress abstracts, master theses, websites and as an educational tool in vocational teaching, Conclusions: The rapidly growing list of practical applications provides face-validity for the usefulness of this freely available new terminological resource.
BibTeX:
@article{Jamoulle2018,
  author = {Jamoulle, Marc and Resnick, Melissa and Grosjean, Julien and Ittoo, Ashwin and Cardillo, Elena and Vander Stichele, Robert and Darmoni, Stefan and Vanmeerbeek, Marc},
  title = {Development, dissemination, and applications of a new terminological resource, the {Q}-{Code} taxonomy for professional aspects of general practice/family medicine},
  month = {December},
  journal = {The European journal of general practice},
  year = {2018},
  volume = {24},
  number = {1},
  pages = {68--73},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/29243572},
  doi = {10.1080/13814788.2017.1404986}
}

Abstract: PURPOSE: Microsurgical reconstruction in a vessel-depleted neck is a challenge due to the lack of reliable vessels in or nearby the host site. The use of the internal thoracic pedicle (ITP) by rib section or sparring is a limited option due to the small length of the pedicle of some flaps. However, in cardiac surgery, the internal thoracic artery (ITA) is widely used for myocardial revascularization, providing a long and versatile pedicle. We aimed at determining precise anatomical bases for the use of the ITP, approached by sternotomy and rerouted in the neck, as recipient vessels for free-flap facial reconstructions. METHODS: We performed a descriptive single centre anatomical study on 20 formalin-embalmed cadavers. The ITP was harvested on both sides from the emergence of the artery under the brachiocephalic vein to its terminal division. The level reached by the ITP in the cervicofacial area was described. Distal arterial and venous diameters, pedicle length and other parameters were measured. RESULTS: In at least 85% of the cases, the ITP reached the mandibular angle. The mean diameter at the distal extremity for the ITA was 2.36 ± 0.15, and 2.48 ± 0.19 mm for the committing vein. The mean length of the ITP was 177.3 mm. CONCLUSION: Rerouting the ITP towards the cervicofacial area could provide a reliable pedicle for free-flap reconstructions in patients with a vessel-depleted neck but it should be limited to selected patients. This novel solution for situations where current techniques are unfeasible warrants further clinical research.
BibTeX:
@article{Morel2018,
  author = {Morel, François and Crampon, Frédéric and Adnot, Jérôme and Litzler, Pierre-Yves and Duparc, Fabrice and Trost, Olivier},
  title = {Rerouting the internal thoracic pedicle: a novel solution for maxillofacial reconstruction in vessel-depleted situations? A preliminary anatomic study},
  month = {August},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2018},
  volume = {40},
  number = {8},
  pages = {911--916},
  doi = {10.1007/s00276-017-1965-1}
}

Abstract: BACKGROUND: Unstructured health documents (e.g. discharge summaries) represent an important and unavoidable source of information.
METHODS: A semantic annotator identified all the concepts present in the health documents from the clinical data warehouse of the Rouen University Hospital.
RESULTS: 2,087,784,055 annotations were generated from a corpus of about 11.9 million documents with an average of 175 annotations per document. SNOMED CT, NCIt and MeSH were the top 3 terminologies that reported the most annotation.
DISCUSSION: As expected, the most general terminologies with the most translated concepts were those with the most concepts identified.
BibTeX:
@article{Ndangang2018,
  author = {Ndangang, Marie and Grosjean, Julien and Lelong, Romain and Dahamna, Badisse and Kergourlay, Ivan and Griffon, Nicolas and Darmoni, Stéfan J.},
  title = {Terminology {Coverage} from {Semantic} {Annotated} {Health} {Documents}},
  journal = {Studies in Health Technology and Informatics},
  year = {2018},
  volume = {255},
  pages = {20--24},
  doi = {10.3233/978-1-61499-921-8-20}
}

Abstract: Background: Burnout is a common occurrence among GPs, decreasing quality of and access to care and impacting both physician and patient health. The link between burnout and low medical density has never been studied.
Objectives: This study aimed to assess the prevalence of burnout and its related factors, including low medical density, among GPs.
Method: We conducted a cross-sectional survey. A self-administered questionnaire was sent to all of the 1632 GPs in Normandy, France, in September 2015. The Maslach Burnout Inventory was used to assess the three burnout dimensions: emotional exhaustion (EE), depersonalization (DP) and low personal accomplishment (PA).
Results: In all, 501 GPs sent back their questionnaire (response rate: 30.7; 487 questionnaires were analysed. Burnout had been experienced by 43.3% of the physicians in the sample. Nearly 24% of the respondents scored high EE, 27.3% scored high DP, and 13.3% scored low PA. Low medical density [odds ratios (OR): 2.16 (1.31-3.54)], and intent to quit [OR: 4.40 (2.59-7.47)] were strongly linked to the three burnout dimensions. Burnout was not linked with quantitative workload.
Conclusion: Burnout among GPs was common. Low medical density and intent to quit were strong predictors of burnout. Given the current medical demographic crisis, these results highlight the relationship between burnout and medical shortage. Qualitative workload may have a more significant influence on burnout than quantitative workload. Recruiting more GPs is necessary, but may prove insufficient in fighting burnout. Preventive and curative actions are required, especially in areas with low medical density.
BibTeX:
@article{Picquendar2018,
  author = {Picquendar, Guillaume and Guedon, Antoine and Moulinet, Fanny and Schuers, Matthieu},
  title = {Influence of medical shortage on {GP} burnout: a cross-sectional study},
  month = {September},
  journal = {Family Practice},
  year = {2018},
  doi = {10.1093/fampra/cmy080}
}

Abstract: Objective
There is a growing interest in using natural language processing (NLP) for healthcare-associated infections (HAIs) monitoring. A French project consortium, SYNODOS, developed a NLP solution for detecting medical events in electronic medical records for epidemiological purposes. The objective of this study was to evaluate the performance of the SYNODOS data processing chain for detecting HAIs in clinical documents.
Materials and methods
The collection of textual records in these hospitals was carried out between October 2009 and December 2010 in three French University hospitals (Lyon, Rouen and Nice). The following medical specialties were included in the study: digestive surgery, neurosurgery, orthopedic surgery, adult intensive-care units. Reference Standard surveillance was compared with the results of automatic detection using NLP. Sensitivity on 56 HAI cases and specificity on 57 non-HAI cases were calculated.
Results
The accuracy rate was 84% (n = 95/113). The overall sensitivity of automatic detection of HAIs was 83.9% (CI 95 71.7–92.4) and the specificity was 84.2% (CI 95 72.1–92.5). The sensitivity varies from one specialty to the other, from 69.2% (CI 95 38.6–90.9) for intensive care to 93.3% (CI 95 68.1–99.8) for orthopedic surgery. The manual review of classification errors showed that the most frequent cause was an inaccurate temporal labeling of medical events, which is an important factor for HAI detection.
Conclusion
This study confirmed the feasibility of using NLP for the HAI detection in hospital facilities. Automatic HAI detection algorithms could offer better surveillance standardization for hospital comparisons.
BibTeX:
@article{Tvardik2018,
  author = {Tvardik, Nastassia and Kergourlay, Ivan and Bittar, André and Segond, Frédérique and Darmoni, Stefan and Metzger, Marie-Hélène},
  title = {Accuracy of using natural language processing methods for identifying healthcare-associated infections},
  month = {September},
  journal = {International Journal of Medical Informatics},
  year = {2018},
  volume = {117},
  pages = {96--102},
  url = {http://www.sciencedirect.com/science/article/pii/S1386505618304362},
  doi = {10.1016/j.ijmedinf.2018.06.002}
}

BibTeX:
@article{Lacroix-Hugues2018,
  author = {Lacroix-Hugues, V. and Schuers, M. and Pradier, C. and Staccini, P. and Letrilliart, L. and Darmon, D.},
  title = {Utilisation des enregistrements médicaux électroniques dans le cadre du projet {PRIMEGE} {PACA}},
  month = {May},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2018},
  number = {143},
  pages = {197--203},
  url = {https://www.lissa.fr/fr/rep/articles/AA_1015780242018143197203utilla}
}

Abstract: Les infections urinaires masculines (IUM) sont un continuum allant des formes cliniques paucisymptomatiques (« cystite-like » dans la littérature anglo-saxonne) à la prostatite et à l’urosepsis sévère. La bandelette urinaire positive pour leucocytes et/ou nitrites conforte la suspicion clinique mais ne dispense pas de l’examen cytobactériologique des urines. En présence de fièvre, d’une mauvaise tolérance, d’une rétention aiguë d’urine, le traitement doit être introduit sans tarder. Les IUM paucisymptomatiques doivent être documentées et les patients réévalués. Le caractère fruste
permet de décaler si possible l’introduction d’une antibiothérapie. La ciprofloxacine et la lévofloxacine sont les traitements de référence pour une durée de 14 jours quelle que soit l’intensité de l’IUM. L’ofloxacine ne doit plus être prescrite de façon probabiliste en raison d’une augmentation des résistances en soins premiers.
BibTeX:
@article{Soudais2018,
  author = {Soudais, B and Schuers, M and Lefebvre, E and Etienne, M and Pellerin, L},
  title = {Infections urinaires masculines en soins primaires},
  month = {October},
  journal = {exercer, la revue française de médecine générale},
  year = {2018},
  number = {146},
  pages = {368--73},
  url = {https://www.exercer.fr/numero/146/page/368/}
}

BibTeX:
@inproceedings{Douze2018,
  author = {Douze, L and Kerdelhue, G and Grosjean, J and Schiro, J and Pelayo, S and Marcilly, R},
  title = {Search engines in medicine: the need to involve healthcare professional end users},
  booktitle = {MIE},
  year = {2018}
}

BibTeX:
@inproceedings{Lelong2018,
  author = {Romain Lelong and Lina F. Soualmia and Saoussen Sakji and Badisse Dahamna and Stéfan Darmoni},
  title = {NoSQL technology in order to support Semantic Health Search Engine},
  booktitle = {MIE 2018},
  year = {2018}
}

Abstract: La base de données bibliographiques LiSSa (Littérature scientifique en santé) (www.lissa.fr) référence plus d'un million d'articles francophones et vise à les rendre plus visibles à l'heure où la place de la langue française pour ces publications est de plus en plus discutée. La base a été créée à l'aide de multiples sources de données publiques et privées et la contribution de plusieurs éditeurs. Le moteur de recherche peut être interrogé simplement et apporter des résultats pertinents. Un formulaire de recherche avancée et des options spécifiques permettent également de mener des recherches plus complexes. Des fonctionnalités d'exportations et d'alertes sont également disponibles pour manipuler facilement les références et être tenu informé.
BibTeX:
@article{Kerdelhue2018,
  author = {Gaétan Kerdelhué and Jean-Francois Gehanno and Julien Grosjean and Stéfan Darmoni},
  title = {La base de données bibliographiques LiSSa (Littérature scientifique en santé) : intérêt et utilisation pour la santé au travail},
  journal = {Références en Santé au Travail},
  year = {2018},
  number = {154},
  pages = {115-119},
  url = {http://www.rst-sante-travail.fr/rst/pages-article/ArticleRST.html?ref=RST.TM%2046}
}

2017


Abstract: The purpose of this anatomic study was to compare the retraction force necessary to expose the mandibular neck in the Risdon and the high cervical anteroparotid transmasseteric (HAT) approaches. An anatomic study was performed on 18 formalin-embalmed cadavers. We performed a Risdon approach on the left side, and an HAT approach on the right side in all the cases. The subjects were placed in a normative frame and the force necessary to maintain a satisfactory exposure of the condyle was measured with a system of cables, pulleys, and mechanical dynamometer. The statistical comparison between the two sides was carried out using the Wilcoxon signed-rank test for paired series. In all the cases, the region of interest was exposed as in the operating room. In the Risdon approach, the mean force was 32 Newtons (4-47). In the HAT approach, the mean force was 19 Newtons (4-33). The difference was statistically significant (p < 0.001). The age, gender, and duration of conservation had no influence on the retraction force. In the HAT approach, the retraction of the soft tissues was significantly lower than in the Risdon approach. This study gave an additional explanation to the remarkable safety of the HAT approach. Our results were in favor of the generalization of this technique.
BibTeX:
@article{Adnot2017,
  author = {Adnot, Jérôme and Feuss, Aliosha and Duparc, Fabrice and Trost, Olivier},
  title = {Retraction force necessary to expose the mandibular neck in Risdon and high cervical anteroparotid transmasseteric approaches: an anatomic comparative study.},
  month = {April},
  journal = {Surgical and radiologic anatomy : SRA},
  year = {2017},
  doi = {10.1007/s00276-017-1853-8}
}

Abstract: The authors report the case of a 43-year-old woman who underwent endodontic treatment of the right second mandibular molar with substantial extrusion of endodontic material into the mandibular canal. The patient presented at the Department of Oral and Maxillofacial Surgery with a persistent total anaesthesia of the lower lip and chin after two months. 2D panoramic view and 3D CT-scan examination highlighted the overfilling into the mandibular canal with a more than 50% stenosis of the canal and a consequently significant compression of the dental pedicle. A surgical decompression of the inferior alveolar nerve was performed through an inferior vestibular approach, using PiezoSurgery®. The tooth was conserved. After a period of 8days, paraesthesia of the lower lip and chin appeared. Thermoalgic sensitivity was recovered at 1month. At 3months postoperatively, the patient had recovered protopathic and epicritic sensitivity. Dental prosthetic rehabilitation was finally achieved one year postoperatively. The authors discuss the physiopathology of nervous injuries during dental procedures, and further strategies in the case of persistent neurologic disorders.
BibTeX:
@article{Bastien2017,
  author = {Bastien, A.-V. and Adnot, J. and Moizan, H. and Calenda, É. and Trost, O.},
  title = {Secondary surgical decompression of the inferior alveolar nerve after overfilling of endodontic sealer into the mandibular canal: Case report and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2017},
  volume = {118},
  number = {6},
  pages = {389--392},
  doi = {10.1016/j.jormas.2017.09.001}
}

Abstract: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Classical Pharmacovigilance process is limited by underreporting which justifies the current interest in new knowledge sources such as social media. The Adverse Drug Reactions from Patient Reports in Social Media (ADR-PRISM) project aims to extract ADRs reported by patients in these media. We identified 5 major challenges to overcome to operationalize the analysis of patient posts: (1) variable quality of information on social media, (2) guarantee of data privacy, (3) response to pharmacovigilance expert expectations, (4) identification of relevant information within Web pages, and (5) robust and evolutive architecture. This article aims to describe the current state of advancement of the ADR-PRISM project by focusing on the solutions we have chosen to address these 5 major challenges. In this article, we propose methods and describe the advancement of this project on several aspects: (1) a quality driven approach for selecting relevant social media for the extraction of knowledge on potential ADRs, (2) an assessment of ethical issues and French regulation for the analysis of data on social media, (3) an analysis of pharmacovigilance expert requirements when reviewing patient posts on the Internet, (4) an extraction method based on natural language processing, pattern based matching, and selection of relevant medical concepts in reference terminologies, and (5) specifications of a component-based architecture for the monitoring system. Considering the 5 major challenges, we (1) selected a set of 21 validated criteria for selecting social media to support the extraction of potential ADRs, (2) proposed solutions to guarantee data privacy of patients posting on Internet, (3) took into account pharmacovigilance expert requirements with use case diagrams and scenarios, (4) built domain-specific knowledge resources embeding a lexicon, morphological rules, context rules, semantic rules, syntactic rules, and post-analysis processing, and (5) proposed a component-based architecture that allows storage of big data and accessibility to third-party applications through Web services. We demonstrated the feasibility of implementing a component-based architecture that allows collection of patient posts on the Internet, near real-time processing of those posts including annotation, and storage in big data structures. In the next steps, we will evaluate the posts identified by the system in social media to clarify the interest and relevance of such approach to improve conventional pharmacovigilance processes based on spontaneous reporting.
BibTeX:
@article{Bousquet2017,
  author = {Bousquet, Cedric and Dahamna, Badisse and Guillemin-Lanne, Sylvie and Darmoni, Stefan J and Faviez, Carole and Huot, Charles and Katsahian, Sandrine and Leroux, Vincent and Pereira, Suzanne and Richard, Christophe and Schück, Stéphane and Souvignet, Julien and Lillo-Le Louët, Agnès and Texier, Nathalie},
  title = {The Adverse Drug Reactions from Patient Reports in Social Media Project: Five Major Challenges to Overcome to Operationalize Analysis and Efficiently Support Pharmacovigilance Process.},
  month = {September},
  journal = {JMIR research protocols},
  year = {2017},
  volume = {6},
  pages = {e179},
  doi = {10.2196/resprot.6463}
}

Abstract: Introduction
In January 2015, Rouen University Hospital’s information system experienced serious issues. It was necessary to rapidly switch from the computerized provider order entry (CPOE) system towards a paper-based order entry (PBOE) system. This was an opportunity to evaluate prescriber opinion on the two provider order entry (POE) systems.
Methods
All residents were asked to fill an augmented version of the POE satisfaction and usage survey for both POE systems. The results were compared to identify the strengths and weaknesses of each system.
Results
Fifty-one respondents had used the CPOE system and the PBOE system. Overall, satisfaction was higher with PBOE than CPOE (odds ratio (OR) = 3.74; p < 0.001). Usability (OR = 4.00; p < 0.001), reliability (OR = 8.54; p < 0.001), time consumption (OR = 0.50; p < 0.05 – survey statement was formulated negatively), and communication with nurses (OR = 14.27; p < 0.0001) reached statistically better agreement. The more experience with CPOE the more residents were disillusioned with the reliability (OR = 6.55; p < 0.01), the usability (OR = 5.68; p < 0.01) and the patient safety (OR = 0.27; p < 0.05 – survey statement was formulated negatively) of CPOE. Although safety issues were reported for both systems, the causes were different; PBOE imposed frequent rewriting of the order while CPOE lack of usability might be unsafe. Another important issue with both POE systems was time consumption.
Conclusion
Residents did not report any increase in safety issues with the rapid switch from CPOE to PBOE. They even seemed more satisfied with the rollback to paper, which remains a possible degraded mode in case of health information technology collapse.
BibTeX:
@article{Griffon2017,
  author = {Griffon, N. and Schuers, M. and Joulakian, M. and Bubenheim, M. and Leroy, J.-P. and Darmoni, S. J.},
  title = {Physician satisfaction with transition from {CPOE} to paper-based prescription},
  month = {July},
  journal = {International Journal of Medical Informatics},
  year = {2017},
  volume = {103},
  pages = {42--48},
  url = {http://www.ijmijournal.com/article/S1386-5056(17)30085-0/abstract},
  doi = {10.1016/j.ijmedinf.2017.04.007}
}

Abstract: This case control study assessed: the relationship of systemic sclerosis (SSc) related to exposure to heavy metals, the risk of SSc related to occupational exposure in male and female patients. From 2005 to 2008, 100 patients with a definite diagnosis of SSc were included in the study; 3 age, gender, and smoking habits matched controls were selected for each patient. All SSc patients and controls underwent detection and quantification of heavy metal traces in hair samples, using multi-element inductively coupled plasma mass spectrometry (ICP-MS). SSc patients exhibited higher median levels of the following metals: antimony (p=0.001), cadmium (p=0.0003), lead (p=0.02), mercury (p=0.02), molybdenum (p=0.04), palladium (p<0.001) and zinc (p=0.0003). A marked association between SSc and occupational exposure was further found for: 1) antimony (p=0.008) and platinum (p=0.04) in male patients; and 2) antimony (p=0.02), cadmium (p=0.001), lead (p=0.03), mercury (p=0.03), palladium (p=0.0003) and zinc (p=0.0001) in female patients CONCLUSION: The results show the impact of occupational risk factors in the development of SSc for: antimony, cadmium, lead, mercury, molybdenum, palladium and zinc. Thus, occupational exposure should be systematically checked in all SSc patients at diagnosis. Finally, the association between SSc and occupational exposure may be variable according to patients" gender.
BibTeX:
@article{Marie2017,
  author = {Marie, I and Gehanno, J-F and Bubenheim, M and Duval-Modeste, A-B and Joly, P and Dominique, S and Bravard, P and Noël, D and Cailleux, A-F and Weber, J and Lagoutte, P and Benichou, J and Levesque, H and Goullé, J-P},
  title = {Systemic sclerosis and exposure to heavy metals: A case control study of 100 patients and 300 controls.},
  month = {January},
  journal = {Autoimmunity reviews},
  year = {2017},
  doi = {10.1016/j.autrev.2017.01.004}
}

Abstract: MEDLINE is the most widely used medical bibliographic database in the world. Most of its citations are in English and this can be an obstacle for some researchers to access the information the database contains. We created a multilingual query builder to facilitate access to the PubMed subset using a language other than English. The aim of our study was to assess the impact of this multilingual query builder on the quality of PubMed queries for non-native English speaking physicians and medical researchers. A randomised controlled study was conducted among French speaking general practice residents. We designed a multi-lingual query builder to facilitate information retrieval, based on available MeSH translations and providing users with both an interface and a controlled vocabulary in their own language. Participating residents were randomly allocated either the French or the English version of the query builder. They were asked to translate 12 short medical questions into MeSH queries. The main outcome was the quality of the query. Two librarians blind to the arm independently evaluated each query, using a modified published classification that differentiated eight types of errors. Twenty residents used the French version of the query builder and 22 used the English version. 492 queries were analysed. There were significantly more perfect queries in the French group vs. the English group (respectively 37.9% vs. 17.9%; p < 0.01). It took significantly more time for the members of the English group than the members of the French group to build each query, respectively 194 sec vs. 128 sec; p < 0.01. This multi-lingual query builder is an effective tool to improve the quality of PubMed queries in particular for researchers whose first language is not English.
BibTeX:
@article{Schuers2017,
  author = {Schuers, Matthieu and Joulakian, Mher and Kerdelhué, Gaetan and Segas, Léa and Grosjean, Julien and Darmoni, Stéfan J and Griffon, Nicolas},
  title = {Lost in translation? A multilingual Query Builder improves the quality of PubMed queries: a randomised controlled trial.},
  month = {July},
  journal = {BMC medical informatics and decision making},
  year = {2017},
  volume = {17},
  pages = {94},
  doi = {10.1186/s12911-017-0490-9}
}

Abstract: Metopism (complete persistence of the metopic suture in adults) is a rare but not exceptional variation of the calvaria. Hypoplasia or aplasia of the frontal sinus may be associated without evident correlation. Nevertheless, a misdiagnosis of these variations may have clinical consequences, especially in a traumatic context. The aim of this paper was to report a case of metopism associated with a unilateral aplasia of the left frontal sinus, originally illustrated with 3D image fusion volume rendering reconstructions.
BibTeX:
@article{Eliezer2017,
  author = {Eliezer, M. and Crampon, F. and Adnot, J. and Duparc, F. and Trost, O.},
  title = {Représentation tridimensionnelle originale d’un cas de métopisme associé à une agénésie unilatérale complète du sinus frontal gauche : intérêt clinique et revue de la littérature},
  month = {May},
  journal = {Morphologie: Bulletin De l'Association Des Anatomistes},
  year = {2017},
  doi = {10.1016/j.morpho.2017.04.004}
}

Abstract: Introduction Les publications scientifiques en français sont de plus en plus éclipsées par les publications en langue anglaise, notamment dans les bases de données bibliographiques internationales. Il s’agit pourtant de ressources potentiellement utiles pour beaucoup de professionnels médicaux et paramédicaux. Objectifs L’objectif de cet article est de présenter un nouvel outil, LiSSa pour « Littérature Scientifique en Santé », qui vise à agréger l’ensemble de la littérature médicale en français, ainsi que les premières étapes de sa conception. Méthodes L’agrégation de différentes bases de données requiert l’harmonisation des métadonnées et l’adaptation du modèle de données. Une évaluation ergonomique préliminaire a été réalisée. Résultats Les données de PubMed et d’Elsevier-Masson ont été intégrées, permettant la mise à disposition d’une base de données bibliographique riche de 869 834 références. Concernant les données postérieures à 2000, LiSSa regroupe 300 988 références, dont 81 239 avec le résumé en français et 209 610 avec un lien vers le texte intégral (dont 15 838 en accès gratuit). L’évaluation ergonomique a confirmé l’intérêt des professionnels de santé pour cet outil et a permis d’aboutir à l’actuelle version de LiSSa qui dispose d’outils de filtre et d’exportation classiques pour ce genre d’outil, ainsi que de liens contextuels vers PubMed et vers le Catalogue et Index des Sites Médicaux en langue Française. Conclusion : LiSSa est gratuitement disponible à l’URL suivante: http://www.lissa.fr .
BibTeX:
@article{Griffon2017a,
  author = {Griffon, N. and Rollin, L. and Schuers, M. and Douze, L. and Rodriguez, D. and Delerue, D. and Dutoit, D. and Dahamna, B. and Kerdelhué, G. and Grosjean, J. and Gehanno, JF. and Darmoni, SJ.},
  title = {{LiSSa}, {Littérature} {Scientifique} en {Santé} : une base de données bibliographique en français},
  journal = {Pratique Neurologique - FMC},
  year = {2017},
  volume = {8},
  number = {4},
  pages = {204-247},
  doi = {10.1016/j.praneu.2017.06.008}
}

BibTeX:
@article{Griffon2016c,
  author = {Griffon, Nicolas and Schuers, Matthieu and Kerdelhué, Gaétan and Grosjean, Julien and Darmoni, Stéfan},
  title = {Littérature scientifique en santé ({LiSSa}) : une base de données bibliographiques en français},
  journal = {La Revue Du Praticien},
  year = {2017},
  volume = {67},
  number = {2},
  pages = {134-138}
}

Abstract: Les médecins généralistes sont désormais encouragés à pratiquer une médecine fondée sur les preuves ou evidence-based medicine (EBM). Cela consiste à combiner son expertise clinique aux données de la science, en tenant compte de la situation de soins et en intégrant les valeurs et les attentes du patient aux propositions qui lui seront faites. Beaucoup de données actualisées des connaissances médicales sont aujourd’hui accessibles par Internet. Il existe pourtant des freins à la recherche efficiente d’information médicale en ligne par le généraliste : le manque de temps ou de repères dans la navigation sur Internet ou la quantité trop importante d’informations à analyser.
BibTeX:
@article{Schuers2017b,
  author = {Matthieu Schuers and Nicolas Griffon and Gaëtan Kerdelhué and Quentin Foubert and Alain Mercier and Stéfan Darmoni},
  title = {Comportement des internes et des généralistes dans la recherche d'informations de santé : de l'intention à la pratique},
  journal = {Exercer},
  year = {2017},
  number = {132},
  pages = {170-171},
  url = {https://www.exercer.fr/full_article/867}
}

BibTeX:
@article{Siedlecki2017,
  author = {Siedlecki, C. and Griffon, N. and Kerdelhué, G.},
  title = {Thèmes et tendances des publications en médecine générale dans {PubMed}},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2017},
  number = {130},
  pages = {70--1},
  url = {https://www.exercer.fr/full_article/848}
}

Abstract: Extracting concepts from medical texts is a key to support many advanced applications in medical information retrieval. Entity recognition in French texts is moreover challenged by the availability of many resources originally developed for English texts. This paper proposes an evaluation of the terminology coverage in a corpus of 50,000 French articles extracted from the bibliographic database LiSSa. This corpus was automatically indexed with 32 health terminologies, published in French or translated. Then, the terminologies providing the best coverage of these documents were determined. The results show that major resources such as the NCI and SNOMED CT thesauri achieve the largest annotation of the corpus while specific French resources prove to be valuable assets.
BibTeX:
@article{Cabot2017,
  author = {Cabot, Chloé and Soualmia, Lina F and Grosjean, Julien and Griffon, Nicolas and Darmoni, Stéfan J},
  title = {Evaluation of the Terminology Coverage in the French Corpus LiSSa.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {126--130},
  doi = {10.3233/978-1-61499-753-5-126}
}

BibTeX:
@inproceedings{Chebil2017,
  author = {Wiem Chebil and Lina Fatima Soualmia and Mohamed Nazih Omri and St{\'{e}}fan Jacques Darmoni},
  title = {Indexing biomedical documents with Bayesian networks and terminologies},
  booktitle = {12th International Conference on Intelligent Systems and Knowledge Engineering, {ISKE} 2017, Nanjing, China, November 24-26, 2017},
  year = {2017},
  pages = {1--6},
  url = {https://doi.org/10.1109/ISKE.2017.8258745},
  doi = {10.1109/ISKE.2017.8258745}
}

Abstract: Suspected adverse drug reactions (ADR) reported by patients through social media can be a complementary source to current pharmacovigilance systems. However, the performance of text mining tools applied to social media to discover ADRs needs to be evaluated. In this paper, we introduce the approach developed to mine ADR from French social media. A protocol of evaluation is highlighted, which includes a detailed sample size determination and corpus constitution. Our text mining approach provided very encouraging preliminary results with F-measures of 0.94, 0.81 and 0.70 for recognition of drugs, symptoms and ADRs respectively, thus this approach is promising for downstream pharmacovigilance analysis.
BibTeX:
@inproceedings{Chen2017,
  author = {Chen, C and Deldossi, M and Aboukhamis, R and Faviez, C and Dahamna, B and Karapetiantz, P and Guenegou-Arnoux, A and Girardeau, Y and Guillemin-Lanne, S and Lillo-Le-Louët, A and Texier, N and Burgun, A and Katsahian, S},
  title = {Mining adverse drug reactions in social media with named entity recognition and semantic methods},
  booktitle = {Medinfo},
  year = {2017},
  note = {Accepted}
}

Abstract: The hereby proposed terminology called "Q-Codes" can be defined as an extension of the International Classification of Primary Care (ICPC-2). It deals with non-clinical concepts that are relevant in General Practice/Family Medicine (GP/FM). This terminology is a good way to put an emphasis on underestimated topics such as Teaching, Patient issues or Ethics. It aims at indexing GP/FM documents such as congress abstracts and theses to get a more comprehensive view about the GP/FM domain. The 182 identified Q-Codes have been very precisely defined by a college of experts (physicians and terminologists) from twelve countries. The result is available on the Health Terminology/Ontology Portal (http://www.hetop.org/Q) and formatted in OWL-2 for further semantic considerations and will be used to index the 2016 WONCA World congress communications.
BibTeX:
@article{Jamoulle2017,
  author = {Jamoulle, Marc and Grosjean, Julien and Resnick, Melissa and Ittoo, Ashwin and Treuherz, Arthur and Vander Stichele, Robert and Cardillo, Elena and Darmoni, Stéfan J and Shamenek, Frank S and Vanmeerbeek, Marc},
  title = {A Terminology in General Practice/Family Medicine to Represent Non-Clinical Aspects for Various Usages: The Q-Codes.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {471--475}
}

BibTeX:
@inproceedings{Jamoulle2017a,
  author = {Jamoulle, Marc and Resnick, Melissa and Ittoo, Ashwin and Vander Stichele, Robert and Cardillo, Elena and Grosjean, Julien and Darmoni, Stefan and Vanmeerbeek, Marc},
  title = {Indexing grey multilingual literature in {General} {Practice} in the era of {Semantic} {Web}},
  booktitle = {Nineteenth International Conference on Grey Literature Public Awareness and Access to Grey Literature},
  address = {Rome, Italy},
  month = {October},
  journal = {The Grey Journal},
  year = {2017},
  url = {https://orbi.uliege.be/handle/2268/210490}
}

Abstract: While the digitization of medical documents has greatly expanded during the past decade, health information retrieval has become a great challenge to address many issues in medical research. Information retrieval in electronic health records (EHR) should also reduce the difficult tasks of manual information retrieval from records in paper format or computer. The aim of this article was to present the features of a semantic search engine implemented in EHRs. A flexible, scalable and entity-oriented query language tool is proposed. The program is designed to retrieve and visualize data which can support any Conceptual Data Model. The search engine deals with structured and unstructured data, for a sole patient from a caregiver perspective, and for a number of patients (e.g. epidemiology). Several types of queries on a test database containing 2,000 anonymized patients EHRs (i.e. approximately 200,000 records) were tested. These queries were able to accurately treat symbolic, textual, numerical and chronological data.
BibTeX:
@article{Lelong2017,
  author = {Lelong, Romain and Soualmia, Lina and Dahamna, Badisse and Griffon, Nicolas and Darmoni, Stéfan J},
  title = {Querying EHRs with a Semantic and Entity-Oriented Query Language.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {121--125},
  doi = {10.3233/978-1-61499-753-5-121}
}

Abstract: The emergence of electronic health records has highlighted the need for semantic standards for representation of observations in laboratory medicine. Two such standards are LOINC, with a focus on detailed encoding of lab tests, and SNOMED CT, which is more general, including the representation of qualitative and ordinal test results. In this paper we will discuss how lab observation entries can be represented using SNOMED CT. We use resources provided by the Regenstrief Institute and SNOMED International collaboration, which formalize LOINC terms as SNOMED CT post-coordinated expressions. We demonstrate the benefits brought by SNOMED CT to classify lab tests. We then propose a SNOMED CT based model for lab observation entries aligned with the BioTopLite2 (BTL2) upper level ontology. We provide examples showing how a model designed with no ontological foundation can produce misleading interpretations of inferred observation results. Our solution based on a BTL2 conformant formal interpretation of SNOMED CT concepts allows representing lab test without creating unintended models. We argue in favour of an ontologically explicit bridge between compositional clinical terminologies, in order to safely use their formal representations in intelligent systems.
BibTeX:
@inproceedings{Mary2017,
  author = {Mary, Mélissa and Soualmia, Lina F. and Gansel, Xavier and Darmoni, Stéfan and Karlsson, Daniel and Schulz, Stefan},
  title = {Ontological {Representation} of {Laboratory} {Test} {Observables}: {Challenges} and {Perspectives} in the {SNOMED} {CT} {Observable} {Entity} {Model} {Adoption}},
  booktitle = {Artificial {Intelligence} in {Medicine}},
  month = {June},
  publisher = {Springer, Cham},
  year = {2017},
  series = {Lecture {Notes} in {Computer} {Science}},
  pages = {14--23},
  url = {https://link.springer.com/chapter/10.1007/978-3-319-59758-4_2},
  doi = {10.1007/978-3-319-59758-4_2}
}

BibTeX:
@inproceedings{Merabti2017,
  author = {Merabti, T and Grosjean, J and Darmoni, SJ},
  title = {MT@HeTOP: The Mapping and Translation tool based on the Health multi-terminology portal HeTOP},
  booktitle = {ISHIC2017 2nd International Saudi Health Informatics Conference},
  address = {Riyadh, Kingdom of Saudi of Arabia},
  month = {March},
  year = {2017}
}

BibTeX:
@inproceedings{Lelong2017a,
  author = {Romain Lelong and Lina Soualmia and Saoussen Sakji and Badisse Dahamna and Stéfan Darmoni},
  title = {Une technologie NoSQL au service de moteur de recherche en Santé},
  booktitle = {4ème édition du Symposium sur l'Ingénierie de l'Information Médicale},
  address = {Toulouse},
  month = {Novembre},
  year = {2017}
}

BibTeX:
@inproceedings{Charlet2017,
  author = {Charlet, Jean and Darmoni, St{\'e}fan J.},
  title = {{Formalisation et structure des terminologies en sant{\'e} ; ou plut{\^o}t, {\`a} quoi et comment cela sert ?}},
  booktitle = {{1er forum franco-qu{\'e}becois d'innovation en sant{\'e}}},
  address = {Montr{\'e}al, Unknown Region},
  year = {2017},
  note = {INVITED},
  url = {https://hal.archives-ouvertes.fr/hal-03762173}
}

BibTeX:
@inproceedings{Darmoni2017,
  author = {Darmoni, St{\'e}fan J. and Charlet, Jean and Boudy, J{\'e}r{\^o}me},
  title = {{Quelques nouveaut{\'e}s du domaine de la E-Sant{\'e}}},
  booktitle = {{9^e journ{\'e}e annuelle ITS}},
  address = {Lyon, France},
  year = {2017},
  note = {INVITED},
  url = {https://hal.archives-ouvertes.fr/hal-03762170}
}

BibTeX:
@article{Perrin2017,
  author = {Helene Perrin and Marion Denorme and Julien Grosjean and OMICtools community and Emeric Dynomant and Vincent J. Henry and Fabien Pichon and Stefan Darmoni and Arnaud Desfeux and Bruno J. Gonzalez},
  title = {OMICtools: a community-driven search engine for biological data analysis},
  journal = {CoRR},
  year = {2017},
  volume = {abs/1707.03659},
  url = {http://arxiv.org/abs/1707.03659}
}

BibTeX:
@phdthesis{Cabot2017a,
  author = {Chloé Cabot},
  title = {Recherche d'information clinomique au sein du Dossier Patient Informatisé : modélisation, implantation et évaluation},
  school = {Université de Rouen},
  year = {2017}
}

Abstract: La centralisation des données patients au sein de répertoires numériques soulève des problématiques d’interopérabilité avec les différents systèmes d’information médicaux tels que ceux utilisés en clinique, à la pharmacie ou dans les laboratoires d’analyse. Les instances de santé publique, en charge de développer et de déployer ces dossiers, recommandent l’utilisation de standards pour structurer (syntaxe) et coder l’information (sémantique). Pour les données du diagnostic in vitro (DIV) deux standards sémantiques sont largement préconisés : - la terminologie LOINC® (Logical Observation Identifier Names and Codes) pour représenter les tests de laboratoire ;- l’ontologie SNOMED CT® (Systematized Nomenclature Of MEDicine Clinical Terms) pour exprimer les résultats observés.Ce travail de thèse s’articule autour des problématiques d’interopérabilité sémantique en microbiologie clinique avec deux axes principaux : Comment aligner un Système Organisé de Connaissances du DIV en microbiologie avec l’ontologie SNOMED CT® ? Pour répondre à cet objectif j’ai pris le parti dans mon travail de thèse de développer des méthodologies d’alignement adaptées aux données du diagnostic in vitro plutôt que de proposer une méthode spécifique à l’ontologie SNOMED CT®. Les méthodes usuelles pour l’alignement d’ontologies ont été évaluées sur un alignement de référence entreLOINC® et SNOMED CT®. Les plus pertinentes sont implémentées dans une librairie R, qui sert de point de départ pour créer de nouveaux alignements au sein de bioMérieux. Quels sont les bénéfices et limites d’une représentation formelle des connaissances du DIV ? Pour répondre à cet objectif je me suis intéressée à la formalisation du couple (Observation) au sein d’un compte-rendu de laboratoire. J’ai proposé un formalisme logique pour représenter les tests de la terminologie LOINC® qui a permis de montrer les bénéfices d’une représentation ontologique pour classer et requêter les tests. Dans un second temps, j’ai formalisé un patron d’observations compatible avec l’ontologie SNOMED CT® et aligné sur lesconcepts de la top-ontologie BioTopLite2. Enfin, le patron d’observation a été évaluée afin d’être utilisé au sein des systèmes d’aide à la décision en microbiologie clinique. Pour résumer, ma thèse s’inscrit dans une dynamique de partage et réutilisation des données patients. Les problématiques d’interopérabilité sémantique et de formalisation des connaissances dans le domaine du diagnostic in vitro freinent aujourd’hui encore le développement de systèmes experts. Mes travaux de recherche ont permis de lever certains de ces verrous et pourront être réutilisés dans de nouveaux systèmes intelligents en microbiologie clinique afin de surveiller par exemple l’émergence de bactéries multi-résistantes, et adapter en conséquence des thérapies antibiotiques.
BibTeX:
@phdthesis{Mary2017a,
  author = {Mélissa Mary},
  title = {Interopérabilité sémantique en diagnostic in vitro : représentation des connaissances et alignements avec des terminologies biomédicales},
  school = {Université de Normandie},
  year = {2017},
  url = {http://www.theses.fr/2017NORMR033}
}

Abstract: Les médecins, et en particulier les médecins généralistes, sont confrontésquotidiennement à la difficulté de ne pas tout savoir. En médecine générale, l’étendue duchamp d’activité impose aux professionnels une maîtrise de plus en plus aiguë del’information, qui doit s’appuyer sur le développement d’une littératie numérique, c’està-dire la capacité d’utiliser et de comprendre les outils et médias numériques. Lesobjectifs de ce travail étaient d’identifier les obstacles à la recherche d’information chezles médecins généralistes et de développer et d’évaluer des outils susceptibles desurmonter ces difficultés.Pour cela, nous avons réalisé une étude qualitative auprès d’internes de médecinegénérale et de médecins généralistes français. Elle a permis de mettre en évidence denombreux obstacles à la recherche d’informations en santé en ligne. Ces obstaclesconcernent les professionnels et les outils, certains sont également d’ordre institutionnel.Parmi ces obstacles figure la langue anglaise, qui semble constituer un repoussoir pourles médecins installés mais également pour les médecins en formation. D’après lesdonnées que nous avons recueillies, ce frein concerne aussi bien l’information en ellemêmeque son support.Plusieurs des outils développés par l’équipe du Département d’Informatique etd’Information Médicales du CHU de Rouen ont vocation à répondre à ces difficultés. Labase de données bibliographiques LiSSa permet l’accès à plusieurs centaines de milliersde références francophones en santé, issues de PubMed mais également de revuesfrancophones non indexées dans PubMed. Le constructeur de requêtes bibliographiquesmédicales permet à des utilisateurs non anglophones de construire des équations derecherche complexes dans leur langue maternelle, leur permettant de requêter dansPubMed, LiSSa ou CISMeF
BibTeX:
@phdthesis{Schuers2017a,
  author = {Matthieu Schuers},
  title = {Évaluation d'outils d'accès à la connaissance en médecine générale},
  school = {université de Normandie},
  year = {2017},
  url = {https://tel.archives-ouvertes.fr/tel-01887674/}
}

2016


BibTeX:
@article{Bouvry2016,
  author = {Bouvry, C. and Tvardik, N. and Kergourlay, I. and Bittar, A. and Arnod-Prin, P. and Segond, F. and Dini, L. and Darmoni, S. and Metzger, M.H.},
  title = {The {SYNODOS} {Project}: {System} for the {Normalization} and {Organization} of {Textual} {Medical} {Data} for {Observation} in {Healthcare}},
  month = {April},
  journal = {IRBM},
  year = {2016},
  volume = {37},
  number = {2},
  pages = {109--115},
  url = {http://linkinghub.elsevier.com/retrieve/pii/S1959031816300045},
  doi = {10.1016/j.irbm.2016.03.002}
}

Abstract: In this article, we propose a new approach for indexing biomedical
documents based on a possibilistic network that carries out partial
matching between documents and biomedical vocabulary. The main contribution
of our approach is to deal with the imprecision and uncertainty of
the indexing task using possibility theory. We enhance estimation
of the similarity between a document and a given concept using the
two measures of possibility and necessity. Possibility estimates
the extent to which a document is not similar to the concept. The
second measure can provide confirmation that the document is similar
to the concept. Our contribution also reduces the limitation of partial
matching. Although the latter allows extracting from the document
other variants of terms than those in dictionaries, it also generates
irrelevant information. Our objective is to filter the index using
the knowledge provided by the Unified Medical Language System®. Experiments
were carried out on different corpora, showing encouraging results
(the improvement rate is +26.37% in terms of main average precision
when compared with the baseline).
BibTeX:
@article{Chebil2014,
  author = {Chebil, Wiem and Soualmia, Lina Fatima and Omri, Mohamed Nazih and Darmoni, Stéfan Jacques},
  title = {Indexing biomedical documents with a possibilistic network},
  month = {April},
  journal = {Journal of the Association for Information Science and Technology},
  year = {2016},
  volume = {67},
  number = {4},
  pages = {928-941},
  url = {http://onlinelibrary.wiley.com/doi/10.1002/asi.23435/abstract},
  doi = {10.1002/asi.23435}
}

Abstract: BACKGROUND: Health care workers (HCWs) are considered to be at higher
risk of tuberculosis (TB) than the general population. However, a
decreasing incidence in the general population as well as improvement
in preventive measures in hospitals has reduced the risk for HCWs.
AIMS: To quantify the actual incidence of TB in nurses and health
care assistants in a low-incidence country. METHODS: We performed
a retrospective study of 80 hospitals throughout France, employing
233389 health care staff (physicians excluded). We calculated the
number of pulmonary TB cases over 3 years (700166 person-years) and
the total number of staff members in each job category (nurses, health
care assistants, administrative staff) in each hospital, to calculate
the incidence. RESULTS: Overall, the incidence rate varied between
1.27 and 6/100000 for administrative staff and nurses, respectively
(non-significant difference). The incidence varied according to the
geographical area. However, the incidence in nurses and health care
assistants was not different from the general population (7.5/100000).
CONCLUSIONS: In a low-incidence country, such as France, the implementation
of measures to prevent occupational TB among HCWs has been effective.
These preventive measures should be maintained but medical follow-up
could be revised.
BibTeX:
@article{Gehanno2016a,
  author = {Gehanno, J.-F. and Abiteboul, D. and Rollin, L.},
  title = {Incidence of tuberculosis among nurses and health care assistants in {France}.},
  month = {September},
  journal = {Occupational medicine (Oxford, England)},
  year = {2016},
  doi = {10.1093/occmed/kqw138}
}

Abstract: Despite international initiatives like Orphanet, it remains difficult
to find up-to-date information about rare diseases. The aim of this
study is to propose an exhaustive set of queries for PubMed based
on terminological knowledge and to evaluate it versus the queries
based on expertise provided by the most frequently used resource
in Europe: Orphanet.Four rare disease terminologies (MeSH, OMIM,
HPO and HRDO) were manually mapped to each other permitting the automatic
creation of expended terminological queries for rare diseases. For
30 rare diseases, 30 citations retrieved by Orphanet expert query
and/or query based on terminological knowledge were assessed for
relevance by two independent reviewers unaware of the query's origin.
An adjudication procedure was used to resolve any discrepancy. Precision,
relative recall and F-measure were all computed.For each Orphanet
rare disease (n = 8982), there was a corresponding terminological
query, in contrast with only 2284 queries provided by Orphanet. Only
553 citations were evaluated due to queries with 0 or only a few
hits. There were no significant differences between the Orpha query
and terminological query in terms of precision, respectively 0.61
vs 0.52 (p = 0.13). Nevertheless, terminological queries retrieved
more citations more often than Orpha queries (0.57 vs. 0.33; p = 0.01).
Interestingly, Orpha queries seemed to retrieve older citations than
terminological queries (p < 0.0001).The terminological queries proposed
in this study are now currently available for all rare diseases.
They may be a useful tool for both precision or recall oriented literature
search.
BibTeX:
@article{Griffon2016a,
  author = {Griffon, N. and Schuers, M. and Dhombres, F. and Merabti, T. and Kerdelhué, G. and Rollin, L. and Darmoni, S. J.},
  title = {Searching for rare diseases in PubMed: a blind comparison of Orphanet expert query and query based on terminological knowledge.},
  journal = {BMC Med Inform Decis Mak},
  school = {S, 75006, Paris, France; Univ Paris 13, Sorbonne Paris Cité, LIMICS (UMR_S 1142), 93430, Villetaneuse, France.},
  year = {2016},
  volume = {16},
  number = {1},
  pages = {101},
  url = {http://dx.doi.org/10.1186/s12911-016-0333-0},
  doi = {10.1186/s12911-016-0333-0}
}

Abstract: Background Physicians are increasingly encouraged to practice evidence-based
medicine (EBM), and their decisions require evidence based on valid
research. Existing literature shows a mismatch between general practitioners’
(GPs) information needs and evidence available online. The aim of
this study was to explore the attitudes and behavior of residents
in general medicine and GPs when seeking medical information online.
Methods Five focus groups (FGs) involving residents in general medicine
and GPs were conducted between October 2013 and January 2014. The
overall number of participants recruited was 35. The focus group
discussion guide focused on participants’ experiences in searching
for health information on the Internet, perceived barriers and possible
solutions for improving the quality of their own search processes.
Descriptive analysis was performed by three researchers. Results
Participants described a wide range of research topics, covering
all general medicine core competencies, and especially patient-oriented
topics. They used a limited list of websites. Participants were not
confident about their ability to assess the quality of the information
they found. Their assessment of data quality was based on intuition,
and they mainly sought concordance with their existing knowledge.
The way the data were exposed was considered very important. Participants
were looking for information that was directly linked to their clinical
practice. Information seeking processes varied among participants.
They felt they had not mastered query building for conducting searches,
and were aware of the impact this shortcoming had on the quality
of their search for information. Conclusions Residents in general
medicine and GPs understood the importance of EBM and the need for
objective and reliable information. The present study highlights
the difficulties in identifying this kind of information, and suggests
ideas for improvement. Available search tools should change in order
to fill the gap with real-world clinical practice, for example by
integrating a patient-centred approach.
BibTeX:
@article{Schuers2016,
  author = {Schuers, Matthieu and Griffon, Nicolas and Kerdelhue, Gaëtan and Foubert, Quentin and Mercier, Alain and Darmoni, Stéfan J.},
  title = {Behavior and attitudes of residents and general practitioners in searching for health information: {From} intention to practice},
  month = {May},
  journal = {International Journal of Medical Informatics},
  year = {2016},
  volume = {89},
  pages = {9--14},
  url = {http://www.sciencedirect.com/science/article/pii/S1386505616300235},
  doi = {10.1016/j.ijmedinf.2016.02.003}
}

Abstract: OBJECTIVES: To summarize excellent current research in the field of
Knowledge Representation and Management (KRM) within the health and
medical care domain. METHOD: We provide a synopsis of the 2016 IMIA
selected articles as well as a related synthetic overview of the
current and future field activities. A first step of the selection
was performed through MEDLINE querying with a list of MeSH descriptors
completed by a list of terms adapted to the KRM section. The second
step of the selection was completed by the two section editors who
separately evaluated the set of 1,432 articles. The third step of
the selection consisted of a collective work that merged the evaluation
results to retain 15 articles for peer-review. RESULTS: The selection
and evaluation process of this Yearbook's section on Knowledge Representation
and Management has yielded four excellent and interesting articles
regarding semantic interoperability for health care by gathering
heterogeneous sources (knowledge and data) and auditing ontologies.
In the first article, the authors present a solution based on standards
and Semantic Web technologies to access distributed and heterogeneous
datasets in the domain of breast cancer clinical trials. The second
article describes a knowledge-based recommendation system that relies
on ontologies and Semantic Web rules in the context of chronic diseases
dietary. The third article is related to concept-recognition and
text-mining to derive common human diseases model and a phenotypic
network of common diseases. In the fourth article, the authors highlight
the need for auditing the SNOMED CT. They propose to use a crowdbased
method for ontology engineering. CONCLUSIONS: The current research
activities further illustrate the continuous convergence of Knowledge
Representation and Medical Informatics, with a focus this year on
dedicated tools and methods to advance clinical care by proposing
solutions to cope with the problem of semantic interoperability.
Indeed, there is a need for powerful tools able to manage and interpret
complex, large-scale and distributed datasets and knowledge bases,
but also a need for user-friendly tools developed for the clinicians
in their daily practice.
BibTeX:
@article{Soualmia2016,
  author = {Soualmia, L. F. and Charlet, J.},
  title = {Efficient {Results} in {Semantic} {Interoperability} for {Health} {Care}. {Findings} from the {Section} on {Knowledge} {Representation} and {Management}},
  month = {November},
  journal = {Yearbook of Medical Informatics},
  year = {2016},
  number = {1},
  pages = {184--187},
  doi = {10.15265/IY-2016-051}
}

Abstract: OBJECTIVES: Summarize excellent current research published in 2015
in the field of Public Health and Epidemiology Informatics. METHODS:
The complete 2015 literature concerning public health and epidemiology
informatics has been searched in PubMed and Web of Science, and the
returned references were reviewed by the two section editors to select
14 candidate best papers. These papers were then peer-reviewed by
external reviewers to allow the editorial team an enlightened selection
of the best papers. RESULTS: Among the 1,272 references retrieved
from PubMed and Web of Science, three were finally selected as best
papers. The first one presents a language agnostic approach for epidemic
event detection in news articles. The second paper describes a system
using big health data gathered by a statewide system to forecast
emergency department visits. The last paper proposes a rather original
approach that uses machine learning to solve the old issue of outbreak
detection and prediction. CONCLUSIONS: The increasing availability
of data, now directly from health systems, will probably lead to
a boom in public health surveillance systems and in large-scale epidemiologic
studies.
BibTeX:
@article{Toubiana2016,
  author = {Toubiana, L. and Griffon, N.},
  title = {Some {Innovative} {Approaches} for {Public} {Health} and {Epidemiology} {Informatics}},
  month = {November},
  journal = {Yearbook of Medical Informatics},
  year = {2016},
  number = {1},
  pages = {247--250},
  doi = {10.15265/IY-2016-047}
}

Abstract: Introduction et objectifs Cancers Pro Doc et Cancers Pro Actu sont
deux outils documentaires sur la prévention des cancers professionnels,
mis en place en 2013 par l’Institut national du cancer (INCa) et
ses partenaires, et qui comptent, fin 2015, plus de 1200 abonnés.
Après ces trois ans d’existence, le comité éditorial a souhaité réaliser
une enquête auprès des abonnés pour évaluer la pertinence et l’utilisation
de ces deux outils et permettre d’identifier des pistes d’amélioration.
Ces deux outils ont pour objectif de faciliter la recherche documentaire
de l’ensemble des professionnels de la santé au travail et de contribuer
à une diffusion plus large des informations parues dans ce domaine.
Cancers Pro Actu, bulletin de veille trimestriel, présente une sélection
d’outils et de supports d’aide à la pratique récemment parus et accessibles
gratuitement sur Internet. Cancers Pro Doc est une base de ressources
documentaires qui répertorie les documents pérennes de Cancers Pro
Actu et dispose d’un moteur de recherche avancée. Méthode et résultats
attendus La communication présentera les premiers enseignements d’une
enquête de satisfaction qui sera réalisée durant le premier semestre 2016 auprès
des abonnés de Cancers Pro Actu et des utilisateurs de Cancers Pro
Doc. L’enquête s’appuiera sur un questionnaire en ligne, puis sur
des entretiens plus approfondis avec des professionnels volontaires.
Par ailleurs, les données de consultation du bulletin de veille et
du site internet seront analysées. Nous disposerons ainsi de données
concernant les habitudes de lecture des utilisateurs, leurs pratiques
en matière de recherches documentaires et leurs perceptions vis-à-vis
des outils mis à disposition. Conclusion L’ensemble des résultats
collectés permettra d’identifier les évolutions nécessaires pour
améliorer Cancers Pro Doc et Cancers Pro Actu et répondre au mieux
aux attentes des abonnés et des lecteurs potentiels. Cette démarche
s’intègre dans une réflexion initiée en 2010 par l’INCa et un ensemble
d’acteurs de la santé au travail sur la circulation de l’information
sur la prévention des cancers professionnels et les possibilités
de l’améliorer.
BibTeX:
@article{Chauvet2016,
  author = {Chauvet, Claire and Jordan, Philippe and Bijaoui, Annie and Delepine, Anne and Fontaine, Bernard and Gehanno, Jean-François and Haberer, Michel and Hasni-Pichard, Helene},
  title = {Cancers {Pro} {Doc} et cancers {Pro} {Actu}. {Premiers} enseignements d’une enquête de lectorat},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {502--502},
  doi = {10.1016/j.admp.2016.03.341}
}

Abstract: Contexte Les différents facteurs ayant un impact sur le retour au
travail des patients atteints d’hémopathies malignes sont peu documentés.
Objectif Décrire et analyser les modalités de reprise et les déterminants
de la réussite ou de l’échec du maintien à l’emploi ou d’une réinsertion
professionnelle des patients atteints d’une hémopathie maligne. Méthode
Étude pilote médico-sociale observationnelle, non randomisée. Inclusion
des sujets atteints d’une hémopathie maligne dans le département
du Calvados, dont le diagnostic a été effectué entre le 1 er janvier
et le 31 décembre 2010, âgés de 18 à 55 ans au moment du diagnostic,
grâce aux données du registre des hémopathies malignes de Basse-Normandie.
Un auto-questionnaire de recueil d’informations propre à l’étude
et des questionnaires validés d’anxiété-dépression, de qualité de
vie et de fatigue ont été adressés aux patients inclus. Principaux
résultats Sur les 144 questionnaires envoyés, 72 questionnaires ont
été recueillis et 20 refus ont été signifiés. La population de l’étude
était constituée de 54 % d’hommes et de 46 % de femmes, avec une
moyenne d’âge de 49,8 ans. Seuls 60 % des sujets déclaraient avoir
bénéficié d’un arrêt de travail suite à la découverte de leur maladie
et la durée moyenne de celui-ci était de 21 mois. À la date de réception
des questionnaires, la majorité des sujets (85  n’était plus en
arrêt de travail. Parmi les sujets ayant bénéficié d’un arrêt de
travail, 47 % des sujets déclaraient avoir rencontré leur médecin
du travail en visite de pré-reprise. La majorité des sujets avait
repris une activité professionnelle dans la même entreprise qu’avant
le diagnostic (77 , avec le même type de contrat de travail (95 ,
et au même poste de travail (77 . La majorité des sujets de l’étude
(79  déclarait n’avoir bénéficié d’aucun aménagement de ses conditions
de travail et 31 % des sujets déclaraient avoir constaté un impact
négatif de leur maladie sur les conditions de reprise de leur activité
professionnelle. Les conditions de reprise du travail étaient considérées
comme suffisamment anticipées pour 56 % seulement des sujets, « pas
du tout » pour 13 % des sujets. Une minorité de sujets (29,5 
déclarait avoir l’impression de travailler « moins bien qu’avant »
la découverte de leur maladie, et 23 % déclaraient s’être sentis
pénalisés dans leur travail à cause de leur maladie. Conclusion Les
données riches recueillies dans le cadre de cette étude pilote et
le taux de réponse satisfaisant permettent d’envisager la réalisation
d’une étude multicentrique, incluant des sujets atteints d’une hémopathie
maligne en Basse-Normandie, Haute-Normandie, dans la zone de proximité
de Lille et dans la Somme.
BibTeX:
@article{Clin2016,
  author = {Clin, Bénédicte and Heutte, Natacha and Troussard, Xavier and Boulanger, Mathilde and Damaj, Ganghi-Laurent and Cornet, Edouard and Bouvier, Véronique and Guizard, Anne-Valérie and Fantoni-Quinton, Sophie and Leroyer, Ariane and Rollin, Laetitia and Doutrellot, Catherine and Launoy, Guy},
  title = {Analyse des déterminants médico-sociaux du maintien en emploi des patients atteints d’une hémopathie maligne (protocole {ADAMENTINE}). {Résultats} de l’étude pilote},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {383--383},
  doi = {10.1016/j.admp.2016.03.054}
}

Abstract: Introduction et méthode Cette étude a pour objectif de repérer les
facteurs de vulnérabilité face à la reprise du travail après un cancer.
Elle porte sur 77 sujets répartis en deux groupes (33 sujets qui
reprennent le travail sans accompagnement et 44 sujets qui s’adressent
à la consultation pluridisciplinaire d’aide à la reprise du travail
après un cancer du CHU de Rouen). Les caractéristiques psychologiques,
médicales, sociales et professionnelles des sujets non consultants
et des sujets consultants sont comparées. Résultats Des facteurs
de vulnérabilité étaient significativement plus souvent présents
chez les sujets consultants : – plus faible sentiment de contrôle
face aux événements traumatisants vécus (questionnaire EVE, Ferreri
et Vacher) ; – plus faible score moyen d’esprit combatif (Mac 44,
Cayrou et Dickès) ; – valeurs liées à la vie professionnelle plus
affectées par la maladie (échelle de valeurs, Fischer) ; – anticipation
d’une moindre compréhension de la part de l’entourage familial face
à la reprise du travail (questionnaire créé pour les besoins de l’étude) ;
– âge inférieur au moment du diagnostic de cancer ; – perte d’emploi
plus fréquente suite au diagnostic. Les taux de reprise du travail
sont de 73 % pour les non consultants et de 66 % pour les consultants.
Le test de Chi 2 ( χ 2 = 0,4086) n’indique pas de différence significative
( p = 0,52) entre les deux groupes. Chez les sujets ayant repris
une activité professionnelle, les délais moyens entre le diagnostic
et la reprise (en mois) sont de 17,54 ± 13,35 pour les sujets consultants
et de 16,78 ± 10,33 pour les non consultants. Le test- t ne montre
pas de différence significative ( p = 0,41) concernant le délai écoulé
entre le diagnostic de cancer et la reprise du travail entre les
sujets des deux groupes. Conclusion Les facteurs de vulnérabilité,
plus souvent présents dans le groupe des sujets ayant consulté, n’ont
pas eu d’incidence sur le taux de reprise du travail et le délai
moyen entre le diagnostic de cancer et la reprise. L’accompagnement
de la consultation d’aide à la reprise du travail a probablement
favorisé une forme de résilience et l’autonomie psychique chez ces
sujets face au retour à l’emploi. Cet accompagnement pourrait faire
émerger des ressources pour faire face à une vulnérabilité durable
dans la vie professionnelle. Les sujets non consultants présentent
des caractéristiques plutôt favorables à la reprise du travail, mais
des difficultés pèsent sur la vie professionnelle après le diagnostic
de cancer. Nous pouvons nous interroger sur le devenir et le vécu
de la reprise du travail, à moyen ou long terme, et sur la valeur
de ces ressources qui pourraient être moins opérantes dans une temporalité
et un contexte différents.
BibTeX:
@article{DeBlasi2016,
  author = {De Blasi, Géraldine and Bouteyre, Evelyne and Gehanno, Jean-François and Rollin, Laetitia},
  title = {Facteurs de vulnérabilité et résilience face à la reprise du travail après un cancer},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {386--387},
  doi = {10.1016/j.admp.2016.03.064}
}

Abstract: La prévention de l’acquisition d’une infection par un soignant constitue
le cœur de métier des professionnels de la lutte contre les infections
associées aux soins et des professionnels de la santé au travail
car : – une infection acquise par un soignant au cours de son activité
dans un établissement de santé (ES) est une infection nosocomiale ;
– un soignant atteint d’une maladie contagieuse peut participer à
la diffusion épidémique de celle-ci dans l’ES ; – une infection chez
un soignant peut conduire, lorsqu’elle est grave et/ou contagieuse
à un arrêt de travail de ce soignant, arrêt de nature à déstabiliser
le fonctionnement du service. La vaccination du personnel de santé
(PS) est une des missions importantes des services de santé au travail.
La vaccination est un moyen de prévention primaire efficace ayant
permis de diminuer, de contrôler, voire d’éradiquer de nombreuses
maladies infectieuses à prévention vaccinale assurant la protection
des populations. Ainsi, la promotion de la vaccination par une politique
vaccinale volontariste représente un enjeu majeur de santé publique.
Pour guider les pratiques, des recommandations vaccinales existent
dont certaines concernent spécifiquement les PS et autres personnels
en contact avec des sujets à risque dans les domaines de la santé
et du médico-social. Malgré ces recommandations, hormis quelques
travaux ayant montré que si les PS étaient globalement bien couverts
par les vaccinations obligatoires, ils étaient en revanche très insuffisamment
couverts par les vaccinations recommandées, les données de couverture
vaccinale (CV) chez le PS ne sont pas nombreuses en France. En 2013,
une action nationale prioritaire d’évaluation et de suivi de la CV
dans les ES a été suggérée, proposition reprise dans les orientations
du Propias 2015. Pour cette raison, le choix a été fait de déployer
le carnet de vaccination électronique (CVE) de MesVaccins.net (association
loi 1901 à but non lucratif). Celui-ci est doté d’un système expert
qui : – assure un diagnostic personnalisé, précis et immédiat de
l’état vaccinal de chaque personnel, et fournit une aide à la décision ;
– permet d’être alerté des vaccinations à programmer, avec intégration
en temps réel de l’évolution des recommandations vaccinales ; – informe
des éventuelles données de pharmacovigilance à prendre en compte.
Le réseau national coordonné par le Raisin se donne pour objectif
de déployer cette méthode standardisée de recueil et de suivi des
vaccinations et des conditions d’immunisation du personnel des ES
à partir du CVE de MesVaccins.net. La phase pilote débute en 2016.
Dans un deuxième temps, le dispositif explorera la capacité de générer
chez les soignants des données de CV à différents échelons géographiques.
BibTeX:
@article{Floret2016,
  author = {Floret, Nathalie and Abiteboul, Dominique and Bouvet, Elisabeth and Gehanno, Jean-François and Guthmann, Jean-Paul and Koeck, Jean-Louis and Launay, Odile and Lecieux, Fabienne and L’heriteau, François and Rabaud, Christian and Rolland, Patrick and Touche, Sylvie and Verdun-Esquer, Catherine},
  title = {Réseau de surveillance de la couverture vaccinale et des conditions d’immunisation du personnel des établissements de santé : pourquoi, comment},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {428--429},
  doi = {10.1016/j.admp.2016.03.175}
}

Abstract: Les soignants sont un groupe professionnel à risque d’exposition au
virus grippal, mais ils sont également régulièrement impliqués dans
des cas ou des épidémies de grippe nosocomiale. Tous les soignants,
et pas uniquement ceux en contact avec des patients à risque, devraient
donc bénéficier de la vaccination contre la grippe. Bien que les
vaccins actuellement disponibles aient une efficacité limitée, tant
pour la prévention de la grippe chez les soignants que pour la réduction
de la morbidité ou de la mortalité des patients à risques, leur rapport
bénéfice–risque reste favorable. Toutefois, les réticences sont fortes
et les taux de vaccination des personnels de soins restent faibles,
notamment en France. Il existe une abondante littérature sur les
actions à mettre en œuvre pour améliorer la couverture vaccinale.
Le fait de rendre la vaccination antigrippale obligatoire pour les
soignants est de nature à atteindre cet objectif, mais avec des inconvénients
qui doivent être pris en considération. Enfin, la politique de prévention
ne peut reposer sur la seule vaccination ; il ne faut pas méconnaître
l’importance du respect des précautions standards dans la prévention
des grippes nosocomiales.
BibTeX:
@article{Gehanno2016,
  author = {Gehanno, J.-F. and Rollin, L.},
  title = {Vaccination antigrippale du personnel soignant},
  journal = {Journal des Anti-infectieux},
  year = {2016},
  volume = {18},
  number = {2},
  pages = {79--84},
  doi = {10.1016/j.antinf.2016.02.001}
}

BibTeX:
@article{Griffon2016b,
  author = {Griffon, Nicolas and Schuers, Matthieu and Darmoni, Stefan J.},
  title = {Littérature {Scientifique} en {Santé} ({LiSSa}) : une alternative à l’anglais ?},
  month = {November},
  journal = {La Presse Médicale},
  year = {2016},
  volume = {45},
  number = {11},
  pages = {955--956},
  url = {http://www.sciencedirect.com/science/article/pii/S0755498216303505},
  doi = {10.1016/j.lpm.2016.11.001}
}

Abstract: Les langages iconiques permettent de représenter des concepts par
la combinaison de primitives graphiques (couleurs, pictogrammes...).
Les exemples sont nombreux, des pan- neaux routiers aux icônes des
interfaces utilisateur. Cependant, ces langages n’associent pas de
sémantique logique à leurs icônes, ce qui peut poser divers problèmes
: des combinaisons inconsistantes de primitives graphiques, des interprétations
différentes d’une même icône par deux personnes, des difficultés
à mettre en correspondance les icônes avec des concepts de ressources
termino-ontologiques existantes... Dans cet article, nous proposons
une méthode de formalisation de la sémantique d’un lan- gage iconique
à l’aide d’une ontologie. Cette méthode a initialement été développée
pour le langage iconique VCM (Visualisation des Concepts en Médecine),
qui permet de représenter par des icônes les principaux concepts
médicaux (antécédents, maladies, traitements...). Nous montrons que
cette méthode est généralisable à d’autres langages iconiques en
l’appliquant à la signalisation routière. Nous décrivons quatre applications
de la formalisation du langage : la vérification de la consistance
des icônes constituées, l’alignement semi-automatique des icônes
avec une terminologie médicale, la génération d’un lexique des pictogrammes
et la génération de libellés pour les icônes.
BibTeX:
@article{Lamy2016,
  author = {Lamy, JB and Soualmia, LF and Duclos, C and Venot, A},
  title = {Formalisation de la Sémantique des Langages Iconiques : Méthode à base d’Ontologie et Applications},
  journal = {Revue d’Intelligence Artificielle},
  year = {2016},
  volume = {30},
  number = {5},
  pages = {579-606},
  url = {http://ria.revuesonline.com/article.jsp?articleId=36942},
  doi = {10.3166/RIA.30.579-606}
}

Abstract: Objectif Décrire les risques psycho-sociaux (RPS) et la santé psychique
des différentes catégories du personnel hospitalier, puis étudier
les liens entre les troubles neuropsychiques et ces RPS. Méthode
et matériels La démarche EVREST a été appliquée en 2014, un entretien
médico-professionnel, avec passation du questionnaire EVREST par
une infirmière ou un médecin du travail, a été proposé aux salariés
nés en octobre d’une année paire du centre hospitalier universitaire
de Rouen ( n = 322). Les résultats quantitatifs et qualitatifs des
entretiens ont été analysés selon le groupe professionnel (médical,
soignant ou non médical-non soignant). Une comparaison avec les résultats
nationaux EVREST 2013–2014 des travailleurs français a été effectuée.
Enfin les facteurs associés aux troubles neuropsychiques ont été
étudiés à l’aide d’une régression logistique. Résultats Deux cent
soixante salariés (taux de participation = 81  ont participé.
Les personnels hospitaliers déclaraient des contraintes psychosociales
plus importantes que les autres travailleurs français, en particulier
le personnel médical et le personnel soignant. La proportion de troubles
neuropsychiques définis par l’association « fatigue et anxiété/nervosité
et troubles du sommeil » était plus importante chez le personnel
hospitalier de façon générale par comparaison aux résultats nationaux
(22 % versus 7 , sans différence significative selon le groupe
professionnel. Les facteurs associés significativement à la présence
de troubles neuropsychiques étaient la pression temporelle (OR =
3,5, IC95 1,7–7,6]), l’absence de possibilité d’entraide (OR =
2,3, IC95 1,0–5,3]) et la peur de perdre son emploi (OR = 5,6 IC95 
[1,7–19,2]). Conclusion Les personnels hospitaliers sont exposés
à des risques psycho-sociaux et déclarent des troubles neuropsychiques
dans des proportions élevées par rapport aux autres travailleurs
français. Des liens significatifs entre troubles neuro-psychiques
et certains RPS ont été mis en évidence. Ces éléments et, en particulier
les éléments qualitatifs entendus lors des entretiens, servent de
base pour le développement d’un plan concret de prévention des RPS
au sein de ce CHU.
BibTeX:
@article{Lesueur2016,
  author = {Lesueur, Nicoleta and Leroyer, Ariane and Gehanno, Jean-François and Caillard, Jean-François and Rollin, Laetitia},
  title = {Évaluation du retentissement des risques psychosociaux sur l’état de santé du personnel hospitalier : étude comparative à l’aide de la démarche {EVREST} dans un centre hospitalier universitaire},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {411--411},
  doi = {10.1016/j.admp.2016.03.125}
}

Abstract: Objectifs Décrire l’impact sur l’état de santé physique et psychique
des différents risques psychosociaux (RPS) auxquels sont exposés
les aides à domicile et les techniciennes d’intervention socio-familiale
(TISF), ainsi que proposer des pistes de prévention des RPS pour
les salariés du secteur de service à la personne. Matériel et méthodes
Étude prospective, monocentrique, descriptive, à l’aide du questionnaire
EVREST (Évolutions et relations en santé au travail) proposé en visite
périodique avec le médecin du travail ou lors d’entretien infirmier,
réalisée sur la période du 1 er octobre 2013 au 30 janvier 2015 pour
les aides à domicile et des TISF travaillant dans le cadre d’une
association d’aide à la personne, en Rouen et agglomération. Résultats
Un total de 246 salariés ont été inclus, principalement des femmes
(99 , avec un âge moyen de 44 ans. Plus de la moitié des salariés
travaillaient à temps partiel et un tiers des salariés travaillait
avec une pression temporelle forte. Ce métier était apprécié sur
certains aspects : près de 8 salariés sur 10 déclaraient faire un
travail varié en pleine autonomie, par contre un tiers de la population
ne disposait pas de possibilités d’entraide. La majorité des salariés
rapportaient des contraintes physiques au poste, pénibles pour la
moitié d’entre eux. Malgré une moyenne d’âge assez jeune, la santé
des salariés était plutôt altérée : atteintes du rachis dorsolombaire
(1/3 des salariés), atteints du membre supérieur (20 , troubles
neuropsychiques (9 . Quarante-sept pour cent des salariés déclaraient
avoir été victimes d’incivilités ou d’agressions physiques répétées
au cours de leur carrière. La pression psychologique était significativement
associée à la présence de troubles neuropsychiques. Conclusion Notre
étude met en évidence des contraintes organisationnelles, physiques
et psychosociales chez les travailleurs à domicile. Les troubles
musculo-squelettiques et neuropsychiques sont associés significativement
à la présence de ces contraintes. Un plan de prévention a pu être
proposé à partir de ces constats.
BibTeX:
@article{Lupse2016,
  author = {Lupse, Mihaela and Gehanno, Jean-François and Meyer, Michèle and Rollin, Laetitia},
  title = {Évaluation du retentissement des risques psychosociaux sur l’état de santé des travailleurs à domicile},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {409--410},
  doi = {10.1016/j.admp.2016.03.121}
}

Abstract: Objectifs Étudier le profil de la situation professionnelle des patients
douloureux chroniques ; – évaluer l’impact de la mise en place d’une
consultation spécialisée « Douleur et Travail » sur le maintien dans
l’emploi des patients douloureux chroniques ; – accompagner les patients
douloureux chroniques pour le maintien dans l’emploi et/ou la reprise
d’une activité professionnelle. Le principe de cette consultation
est la non-substitution au médecin du travail du salarié, le but
étant plutôt l’orientation et la reprise de contact avec celui-ci,
en temps utile, avant la reprise du travail. Méthodologie Les sujets
ayant consulté le Centre d’étude et traitement de la douleur de CHU
de Rouen ou la Structure douleur de l’hôpital d’Évreux et répondant
aux critères d’inclusion suivants sont adressés à la consultation :
– patients non salariés ou n’ayant pas une activité professionnelle,
âgés d’au moins 18 ans, atteints d’une pathologie douloureuse chronique
souhaitant le maintien dans l’emploi ou intégrer le monde du travail ;
– patients salariés atteints d’une pathologie douloureuse chronique,
n’ayant pas eu une visite avec leur médecin du travail dans les six
derniers mois. Critères d’exclusion : – visite avec le médecin du
travail dans les 6 derniers mois ou prévue dans le mois qui suit ;
– démarches de reclassement professionnel déjà en cours ; Trois temps
sont prévus : – une consultation avec pour objectif d’évaluer : – le
statut professionnel, – l’incapacité dans la vie (questionnaire SF-12)
et au travail, – la prise de contact ou non avec le médecin du travail
et les démarches effectuées. Un bilan des aptitudes médicales récentes
est réalisé puis orientation vers les acteurs du maintien dans l’emploi :
– entretien téléphonique au bout de 6 semaines pour évaluation de
l’avancement des démarches entreprises ; – une consultation de suivi
à trois mois pour faire le bilan sur l’avancement des démarches et
conseil. Résultats Les résultats présentés lors du congrès concerneront
les patients ayant bénéficié d’une première consultation entre le
01/11/2015 et le 01/03/2016. À la date du 06/01/2016, 21 patients
sont inclus, notre objectif est d’étudier au moins 30 patients sur
la période totale. L’analyse des résultats concernera le profil des
patients inclus ainsi que le nombre des objectifs accomplis après
la première consultation à trois mois.
BibTeX:
@article{Lupse2016a,
  author = {Lupse, Mihaela and Rollin, Laetitia and Gehanno, Jean François and Gislard, Antoine and Pouplin, Sophie},
  title = {Mise en place d’une consultation spécialisée « {Douleur} et {Travail} » au {CHU} de {Rouen}},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {382--382},
  doi = {10.1016/j.admp.2016.03.052}
}

BibTeX:
@article{Melissa2016,
  author = {Mélissa, Mary and Lina, Soualmia and Xavier, Gansel},
  title = {Interopérabilité sémantique entre vocabulaires contrôlés. évaluation de la qualité des alignements sur des données de standards du diagnostic in vitro},
  month = {December},
  journal = {Ingénierie des systèmes d'information},
  year = {2016},
  volume = {21},
  number = {5-6},
  pages = {55--81},
  url = {http://isi.revuesonline.com/article.jsp?articleId=37160},
  doi = {10.3166/isi.21.5-6.55-83}
}

Abstract: Introduction Les allergies professionnelles sont en très forte augmentation
en France. L’asthme professionnel peut être provoqué par divers allergènes,
selon les corps de métiers. Nous allons présenter un cas d’asthme
professionnel à la tulipe, diagnostiqué en consultation pluridisciplinaire
de médecine du travail et allergologie. Méthodes Une femme de 51
ans, fleuriste, était atteinte de toux, dyspnée et rhino-conjonctivite
lors de l’effeuillage de tulipes, mais ne présentait ni altération
de l’état général ni fièvre. Des tests de provocation bronchique
à la tulipe ont été réalisés en milieu hospitalier. Des prick + prick-tests
à la tulipe étaient réalisés avec le pistil, la feuille, l’étamine,
la tige, la sève de la fleur. Ils ont également été réalisés chez
deux témoins sains. Résultats Le test de provocation bronchique à
la métacholine ainsi que celui à l’effeuillage de tulipes étaient
positifs. L’asthme à la tulipe était donc confirmé. Les prick-tests
à la tulipe n’étaient positifs que chez la patiente, confirmant le
mécanisme allergique IgE médié. Cliniquement, l’éviction de la tulipe
par le changement de poste de travail a permis l’amendement complet
de la symptomatologie. Discussion L’asthme professionnel à la tulipe
est peu connu. Seuls quatre autres cas similaires ont été précédemment
décrits dans la littérature. La tulipe est plus connue en dermato
allergologie car son allergène majeur, la tulipaline A, est responsable
d’allergies de contact fréquentes, croisées avec d’autres fleurs.
Conclusion Nous rapportons un cas exceptionnel d’asthme professionnel
à la tulipe chez une fleuriste. Son diagnostic de certitude nécessite
une méthodologie rigoureuse et chronophage, facilitée par le cadre
d’une consultation pluridisciplinaire de médecine du travail et d’allergologie.
BibTeX:
@article{Merault2016,
  author = {Merault, C. and Tetart, F. and Kuntz, A. and Gehanno, J.F. and Joly, P. and Gislard, A.},
  title = {Asthme professionnel allergique aux liliacées : à propos d’un cas},
  journal = {Revue Francaise d'Allergologie},
  year = {2016},
  volume = {56},
  number = {3},
  pages = {298--298},
  doi = {10.1016/j.reval.2016.02.110}
}

Abstract: La reprise du travail est une étape primordiale pour les patients
atteints d’un cancer mais celle-ci peut s’avérer difficile et nécessiter
un accompagnement adapté. Le Centre de consultations de pathologie
professionnelle CHU de Rouen a créé, en 2006, une consultation pluridisciplinaire
d’aide au retour au travail après un cancer. Les objectifs de cette
étude descriptive étaient de présenter cette consultation, de connaître
le ressenti des patients vis-à-vis d’un tel dispositif et d’identifier
des facteurs prédictifs de retour au travail. Nous avons réalisé
l’analyse descriptive des patients vus entre 2006 et 2011, à partir
des dossiers médicaux, puis nous leur avons envoyé un questionnaire
détaillé sur les conditions de reprise du travail, sur la réalisation
des conseils prodigués lors de la consultation et sur l’intérêt de
cette consultation. Cent vingt et un patients ont été inclus, 22 hommes
(18  et 99 femmes (82 . Les localisations cancéreuses les plus
fréquentes étaient le sein et les hémopathies malignes, respectivement
65 % (79/121) et 12 % (14/121). Quatre-vingt-six patients (71 
étaient en rémission. Cent quatre patients (86  étaient salariés
lors du diagnostic dont 84 (69  en CDI. Les démarches médico-sociales
proposées ont eu un taux de réalisation allant de 28 à 72 % selon
les mesures. Soixante-six pour cent ([IC 95 % = 57–75]) des patients
ont repris, tous délais confondus. Vingt-cinq pour cent, soit 20 des
80 patients ayant repris, expriment des difficultés avec leur employeur
et 18 % (14/80) expriment des difficultés avec les collègues. L’analyse
multivariée a retrouvé trois facteurs associés significativement
à la reprise du travail : avoir un contrat à durée indéterminée lors
du diagnostic de cancer OR = 4,7 IC 95 1,4–16,0], cancer non évolutif
OR = 5 IC 95 1,25–25] et avoir bénéficié d’un accompagnement par
le psychologue de la consultation OR = 2,7 IC 95 1,0–6,9]. Les
différents constats de cette étude ont permis d’établir des pistes
d’amélioration pour cette consultation.
BibTeX:
@article{Rollin2016a,
  author = {Rollin, Laetitia and Boucher, Line and de Blasi, Géraldine and Bouteyre, Evelyne and Gislard, Antoine and Gehanno, Jean-François},
  title = {Évaluation d’une consultation pluridisciplinaire d’aide au retour au travail après cancer},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {395--396},
  doi = {10.1016/j.admp.2016.03.086}
}

Abstract: En France, parmi les 350 000 personnes touchées par le cancer chaque
année, environ 100 000 d’entre elles sont en situation d’emploi et
travaillent au moment du diagnostic. La réinsertion professionnelle
après un cancer est un facteur de qualité de vie des patients, mais
également un enjeu de santé publique. Il s’agit d’une priorité soulignée
dans les plans cancers qui se succèdent depuis 2003. L’objectif de
cette communication est de décrire l’état des connaissances actuelles
concernant le maintien dans l’emploi des patients après cancer. La
métaanalyse deffectuée par Menhert en 2011 a retrouvé un taux de
reprise du travail après cancer de 63,5 % avec des extrêmes allant
de 24 à 94 % selon les études. Cette grande hétérogénéité est expliquée
par des facteurs liés à la pathologie (localisation, stades, traitement),
mais également par d’autres facteurs comme le sens du travail, les
conditions de travail, les cadres légaux et les politiques sociales
variables selon les pays. Il est donc intéressant, dans la réflexion
pour l’accompagnement des patients, d’examiner les études françaises.
L’étude de la DREES, menée en France en 2006, a montré que 67 %
des patients actifs lors du diagnostic avaient repris une activité
professionnelle à 2 ans. Ces données ont permis de mettre en évidence
une différence de vitesse dans le processus de retour à l’emploi
selon le genre, les hommes reprenant plus rapidement dans les 6 mois
qui suivent le diagnostic et les femmes reprenant graduellement dans
les 18 mois. L’étude Vican2 a confirmé que les patients atteints
de cancer étaient plus sujets à la perte d’emploi que la population
générale. Elle a également mis en évidence de fortes inégalités dans
la reprise du travail, les personnes les plus vulnérables vis-à-vis
de la perte d’emploi étant celles appartenant aux catégories socio-professionnelles
dites d’exécution, les plus jeunes et les plus âgées, les personnes
mariées, avec un niveau d’étude inférieur au baccalauréat, avec des
contrats précaires, et celles travaillant dans les petites et moyennes
entreprises. Des interventions visant à améliorer les retours à l’emploi
après cancer ont été mises en place dans de nombreux pays. La métaanalyse
de De Boer et al. a montré que seules les interventions pluridisciplinaires
apportent des résultats probants quant au retour à l’emploi. En revanche,
elles ne sont pas plus efficaces que les « soins ordinaires » sur
la qualité de vie des participants. Les études visant à préciser
le contenu le plus approprié de ces interventions pluridisciplinaires
sont à poursuivre.
BibTeX:
@article{Rollin2016,
  author = {Rollin, Laetitia and De Blasi, Geraldine and Gehanno, Jean-François},
  title = {Cancer et trajectoires professionnelles},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {495--495},
  doi = {10.1016/j.admp.2016.03.323}
}

Abstract: Few data from primary care settings are available about asthma prevalence. The aim of this study was to evaluate the prevalence of asthma consultations in general practice, and to describe their characteristics. This was a multicenter, cross-sectional national study, conducted in general practice. Investigators were 54 interns from 27 medical schools. Between December 2011 and April 2012, they collected and entered variables specific to each consultation over a period of 20 days from a structured electronic health record using the International classification of primary care (ICPC-2) together with data about their trainer(s). Data were recorded for 20,613 consultations with 45,582 consultation outcomes described. Asthma represented 348 (1.69%) of consultations. The presence of an asthma code was associated with fewer reasons for the consultation, but with more processes of care. Forty-two percent of other consultation results associated with asthma in the same consultation concerned chronic diseases. Our findings suggest that asthma remains underdiagnosed in general practice in France. In order to address this problem, the development of validated diagnostic tools that can be used in general practice settings, and a better access to spirometry, may be directions to explore in future research.
BibTeX:
@article{Schuers2016d,
  author = {Schuers, M and Chopinaud, P-A and Guihard, H and Mercier, A},
  title = {Prévalence des consultations pour asthme en médecine générale},
  month = {November},
  journal = {Revue des maladies respiratoires},
  year = {2016},
  volume = {33},
  pages = {781--788},
  doi = {10.1016/j.rmr.2016.01.005}
}

Abstract: Introduction. En France, à la fin des années 1990, 97 % des infections
respiratoires basses (IRB) prises en charge en soins primaires étaient
traitées par antibiotiques. Il n’existe pas de données récentes décrivant
cette situation avec précision. Objectif. L’objectif de cette étude
était de décrire la prescription d’antibiotiques dans les infections
respiratoires basses en France. Méthode. Une étude observationnelle
auprès de médecins généralistes a été réalisée. Les participants
ont été sélectionnés au sein d’un groupe de 200 médecins exerçant
dans deux régions du nord de la France. Tous les médecins ont été
contactés par mail, et ont complété un questionnaire prospectif sur
tous les patients présentant une bronchite aiguë ou une exacerbation
de BPCO.Résultats. Trente-six médecins généralistes ont recruté 193
patients. Cent patients ont reçu un traitement antibiotique (52 .
Des antibiotiques ont été prescrits chez 46 % des patients présentant
une bronchite aiguë et chez 89 % des patients présentant une exacerbation
de BPCO. Le genre féminin des patients (OR : 2,49 ; IC95 : 1,47-4,24),
la durée de la toux (OR : 5,70 ; IC95 : 1,70-19,23), une température
supérieure à 38,5°C (OR : 30,39 ; IC95 : 3,99-231,60) et le diagnostic
d’exacerbation de BPCO (OR : 8,69 ; IC95 : 1,72-43,86) étaient associés
à une proportion plus élevée de prescription d’antibiotiques, toutes
classes confondues. Conclusion. Ces résultats montrent une diminution
significative de la prescription d’antibiotiques dans les IRB, mais
des efforts restent nécessaires pour améliorer la prise en charge
de ces patients.
BibTeX:
@article{Schuers2016b,
  author = {Schuers, M. and Rossignol, L and Laouénan, C and Le Bel, J and Pasque, A and Guihard, H and Aubert, JP and Aubin Auger, I.},
  title = {Prise en charge des infections respiratoires basses en soins primaires en {France} : une étude transversale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2016},
  number = {127},
  pages = {196--203}
}

Abstract: Position du problème Une expérimentation a été lancée en 2013 pour
évaluer l’impact de la consultation du dossier pharmaceutique dans
les services d’urgences, de gériatrie et d’anesthésie-réanimation
de 55 établissements hospitaliers. L’objectif de cette étude était
d’évaluer l’intérêt et l’utilisabilité du dossier pharmaceutique
auprès des médecins et pharmaciens utilisateurs. Méthodes Un auto-questionnaire
électronique a été envoyé à tous les pharmaciens, anesthésistes-réanimateurs,
gériatres et urgentistes des 55 établissements expérimentateurs du
dossier pharmaceutique. Ce questionnaire évaluait l’utilisabilité
du dossier pharmaceutique via la traduction française de l’échelle
d’utilisabilité des systèmes, ainsi que l’usage du dossier pharmaceutique,
son intérêt et ses limites perçues dans la pratique clinique et la
satisfaction générale vis-à-vis de l’outil. Les questionnaires ont
été collectés de novembre 2014 à janvier 2015. Résultats Quatre-vingt-seize
questionnaires ont été recueillis. Ils concernaient 47 centres hospitaliers,
soit 86 % des 55 établissements expérimentateurs du dossier pharmaceutique.
Le recoupement des réponses a permis d’identifier 36 établissements
au sein desquels le dossier pharmaceutique était actif. Soixante-treize
questionnaires remplis par des praticiens ayant pu expérimenter le
dossier pharmaceutique ont pu être exploités. Parmi les répondants,
on comptait 57 % de pharmaciens (n = 42) et 43 % de médecins (n
= 31), dont 13 gériatres, 11 urgentistes et 7 anesthésistes-réanimateurs.
Le score moyen d’utilisabilité du dossier pharmaceutique était de
62,5 sur 100. Il ne variait ni selon la profession du répondant,
ni selon son ancienneté d’exercice. Il était positivement corrélé
à la fréquence d’utilisation. Plus de la moitié des répondants déclaraient
utiliser rarement, ou jamais, le dossier pharmaceutique. La durée
de la période d’accès aux données du dossier était considérée comme
insuffisante. L’absence de mention des posologies des médicaments
délivrés, le faible nombre de patients disposant de leur carte d’assurance
maladie et le faible nombre de patients ayant un dossier pharmaceutique
ouvert constituaient les principaux obstacles à une plus grande utilisation
du dossier pharmaceutique. Conclusion Deux ans après le début de
l’expérimentation visant à élargir l’accès au dossier pharmaceutique
à des professionnels médicaux, les premiers éléments d’évaluation
sont encourageants. Il reste nécessaire d’évaluer les conséquences
de l’accès au dossier pharmaceutique pour les médecins.
BibTeX:
@article{Schuers2016a,
  author = {Schuers, M. and Timsit, M. and Gillibert, A. and Fred, A. and Griffon, N. and Bénichou, J. and Darmoni, S.J. and Staccini, P.},
  title = {Intérêt et utilisabilité du dossier pharmaceutique en pratique médicale. {Enquête} auprès de médecins et pharmaciens hospitaliers (étude {MATRIX})},
  month = {September},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2016},
  volume = {64},
  number = {4},
  pages = {229--236},
  url = {http://linkinghub.elsevier.com/retrieve/pii/S0398762016302905},
  doi = {10.1016/j.respe.2016.05.001}
}

BibTeX:
@article{Cabot2016,
  author = {Cabot, Chloé and Lelong, Romain and Grosjean, Julien and Soualmia, Lina F. and Darmoni, Stéfan J.},
  title = {Retrieving Clinical and Omic Data from Electronic Health Records.},
  journal = {Stud Health Technol Inform},
  school = {TIBS, LITIS EA 4108, Rouen, France.},
  year = {2016},
  volume = {221},
  pages = {115},
  url = {https://www.researchgate.net/profile/Lina_Soualmia/publication/280066101_Integrating_and_Retrieving_Clinical_and_Omic_Data_in_Electronic_Health_Records/links/55a7a47408aeceb8cad65695.pdf},
  doi = {10.3233/978-1-61499-633-0-115}
}

BibTeX:
@inproceedings{Cabot2016a,
  author = {Cabot, C and Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {SIBM at CLEF eHealth Evaluation Lab 2016: Extracting Concepts in French Medical Texts with ECMT and CIMIND},
  booktitle = {2016 Conference and Labs of the Evaluation Forum, CLEF},
  year = {2016},
  pages = {47-60},
  url = {http://ceur-ws.org/Vol-1609/16090047.pdf}
}

BibTeX:
@inproceedings{Gomez-Sanchez2016,
  author = {Gómez-Sánchez, AF and González-Cantalejo, M and Kerdelhué, G and Iriarte, P and Isabel-Gómez, R},
  title = {Evaluating the information retrieval quality and methodological accuracy of Systematic Reviews and Meta-analysis on congenital malformations (2004-2014)},
  booktitle = {EAHIL},
  year = {2016}
}

BibTeX:
@inproceedings{Lelong2016,
  author = {Lelong, R and Cabot, C and Soualmia, LF and Darmoni, SJ},
  title = {Semantic Search Engine to Query into Electronic Health Records with a Multiple-Layer Query Language},
  booktitle = {MEDIR workshop},
  year = {2016},
  url = {http://medir2016.imag.fr/data/MEDIR_2016_paper_8.pdf}
}

BibTeX:
@inproceedings{Cabot2016b,
  author = {Cabot, Chlo{\'e} and Soualmia, Lina F and Dahamna, Badisse and Darmoni, St{\'e}fan J},
  title = {ECMT : Indexation multi-terminologique de documents biom{\'e}dicaux},
  booktitle = {1er Forum Franco-Qu{\'e}b{\'e}cois d'Innovation en Sant{\'e}, Polytechnique Montr{\'e}al},
  year = {2016}
}

BibTeX:
@inproceedings{Henry2016,
  author = {Henry, V and Soualmia, LF and Grosjean, J and Desfeux, A and Darmoni, SJ and Gonzalez, B},
  title = {OMIConto : une Ressource Termino-Ontologique pour la Qualification et l’Indexation des Outils d’Analyse en Sciences Omiques},
  booktitle = {Actes du 2ème Atelier Intelligence Artificielle \& Santé@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  pages = {43-50},
  url = {https://ic2016.sciencesconf.org/conference/ic2016/pages/IA_Sante.pdf}
}

Abstract: Objectif L’objectif de notre étude était de montrer la faisabilité
du recueil de données et de montrer des exemples d’utilisation en
décrivant les principaux motifs de recours ainsi que les principales
classes thérapeutiques prescrites. Méthode Nous avons utilisé les
enregistrements médicaux électroniques (consultations de 2012 à 2015)
de 11 médecins généralistes volontaires recrutés parmi les maîtres
de stage du département de médecine générale de l’université de Nice
Sophia-Antipolis. Certains motifs de consultation ont été codés par
les médecins en utilisant la CISP-2. Les motifs restants ont été
codés a posteriori en utilisant l’extracteur de concepts multiterminologique
(ECMT) développé par l’équipe CISMeF. Résultats Sur 174 212 consultations,
103 571 motifs de consultations ont été renseignés (soit 0,59 motifs
par consultation) ; 16 224 (15,7  comportent un code CISP2 renseigné
par le médecin et 6875 motifs ont été codés a posteriori aboutissant
à un total de 80 099 motifs codés (77,3 .
BibTeX:
@article{Lacroix-Hugues2016,
  author = {Lacroix-Hugues, V. and Darmon, D. and Schuers, M. and Touboul, P. and Pradier, C.},
  title = {Création d’une base de données en médecine générale – projet pilote {PRIMEGE} {PACA}},
  month = {December},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2016},
  series = {8e {Colloque} de {Données} de santé en vie réelle, {Paris}, 2 juin 2016},
  volume = {64, Supplement 6},
  pages = {S301},
  url = {http://www.sciencedirect.com/science/article/pii/S0398762016307374},
  doi = {10.1016/j.respe.2016.10.032}
}

BibTeX:
@inproceedings{Mary2016,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Interopérabilité Sémantique dans le Domaine du Diagnostic in vitro},
  booktitle = {Actes du 2ème Atelier Intelligence Artificielle \& Santé@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  note = {In press}
}

BibTeX:
@inproceedings{Mary2016a,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Évaluation de la Qualité des Liens Sémantiques entre Vocabulaires Contrôlés},
  booktitle = {Actes de l'Atelier SoWeDo (des Sources Ouvertes au Web de Données)@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  url = {https://ic2016.sciencesconf.org/conference/ic2016/pages/SoWeDo_V2.pdf}
}

BibTeX:
@inproceedings{Mary2016d,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Projection des Propriétés d’une Ontologie pour la Classification d’une Ressource Terminologique},
  booktitle = {Actes des 6èmes Journées Francophones sur les Ontologies (JFO)},
  address = {Bordeaux, France},
  year = {2016},
  note = {in press.}
}

BibTeX:
@inproceedings{Siedlecki2016,
  author = {Clémence Siedlecki and Nicolas Griffon and Gaétan Kerdelhué and Julien Grosjean and Benoit Thirion and Marc Jamoulle and Stéfan Darmoni and Matthieu Schuers},
  title = {Thèmes et tendances de recherche en médecine générale : analyse de la littérature extraite de PubMed},
  booktitle = {Congrès du CNGE},
  year = {2016}
}

BibTeX:
@inproceedings{Griffon2016,
  author = {Griffon, N and Rollin, L and Schuers, M and Dhombres, F and Loiseau, S and Douze, L and Marcilly, R and Chabot, O and Delerue, D and Dutoit, D and Dahamna, B and Kerdelhué, G and Grosjean, J and Gehanno, JF and Darmoni, SJ},
  title = {Une base de données bibliographiques en français pour la Littérature Scientifique en Santé : LiSSa},
  booktitle = {JFIM},
  year = {2016}
}

BibTeX:
@inproceedings{Kerdelhue2016,
  author = {Kerdelhué, G and Grosjean, J},
  title = {A tool to design complex bibliographic queries in your own language},
  booktitle = {EAHIL},
  year = {2016}
}

BibTeX:
@inproceedings{Mary2016b,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Interopérabilité Sémantique dans le Domaine du Diagnostic in vitro : Évaluation d’Algorithmes sur LOINC et l’Ontologie SNOMED CT},
  booktitle = {Actes des 27èmes Journées Francophones d'Ingénierie des Connaissances (IC)},
  address = {Montpellier, France},
  year = {2016}
}

BibTeX:
@inproceedings{Mary2016e,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Usability and Improvement of Existing Alignments: the LOINC-SNOMED CT Case Study},
  booktitle = {20th International Conference on Knowledge Engineering and Knowledge Management, EKAW},
  address = {Bologna, Italy},
  year = {2016}
}

BibTeX:
@phdthesis{Chebil2016,
  author = {Wiem Chebil},
  title = {Indexation de documents médicaux avec un réseau possibiliste},
  school = {Université de Monastir},
  year = {2016}
}

2015


Abstract: Objectives: An important barrier to electronic healthcare information
exchanges (HIE) is the lack of interoperability between information
systems especially on the semantic level. In the scope of the ANR
(Agence Nationale pour la Recherche)/TeRSan (Terminology and Data
Elements Repositories for Healthcare Interoperability) project, we
propose to set and use a semantic interoperability platform, based
on semantic web technologies, in order to facilitate standardized
healthcare information exchanges between heterogeneous Electronic
Healthcare Records (EHRs) in different care settings.

Material and methods: The platform is a standard-based expressive
and scalable semantic interoperability framework. It includes centrally
managed Common Data Elements bounded to international/national reference
terminologies such as ICD10, CCAM, SNOMED CT, ICD-O, LOINC and PathLex.
It offers semantic services such as dynamic mappings between reference
and local terminologies.

Results: A pilot implementation of semantic services was developed
and evaluated within an HIE prototype in telepathology for remote
expert advice. The semantic services developed for transcoding local
terms into reference terms take into account the type of message
and the exchange context defined within standard-based integration
profiles.

Conclusion: The TeRSan platform is an innovative semantic interoperability
framework that (1) provides standard-based semantic services applicable
to any HIE infrastructure and (2) preserves the use of local terminologies
and local models by end users (health professionals' priority).
BibTeX:
@article{Aime2015,
  author = {Aimé, X. and Traore, L. and Chniti, A. and Sadou, E. and Ouagne, D. and Charlet, J. and Jaulent, M. -C. and Darmoni, S. and Griffon, N. and Amardeilh, F. and Bascarane, L. and Lepage, E. and Daniel, C.},
  title = {Semantic interoperability platform for {Healthcare} {Information} {Exchange}},
  month = {March},
  journal = {IRBM},
  year = {2015},
  series = {{ANR} {TECSAN} 2015},
  volume = {36},
  number = {2},
  pages = {62--69},
  url = {http://www.sciencedirect.com/science/article/pii/S195903181500024X},
  doi = {10.1016/j.irbm.2015.01.003}
}

Abstract: To summarize the best papers in the field of Knowledge Representation
and Management (KRM).A comprehensive review of medical informatics
literature was performed to select some of the most interesting papers
of KRM published in 2014.Four articles were selected, two focused
on annotation and information retrieval using an ontology. The two
others focused mainly on ontologies, one dealing with the usage of
a temporal ontology in order to analyze the content of narrative
document, one describing a methodology for building multilingual
ontologies.Semantic models began to show their efficiency, coupled
with annotation tools.
BibTeX:
@article{Charlet2015,
  author = {Charlet, J. and Darmoni, S. J.},
  title = {Knowledge Representation and Management. From Ontology to Annotation. Findings from the Yearbook 2015 Section on Knowledge Representation and Management.},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = {Dr Jean Charlet, LIMICS - INSERM U1142, Campus des Cordeliers, 15, rue de l'école de médecine, 75006 Paris, France, Tél. +33 1 44 27 91 09, E-mail: Jean.Charlet@upmc.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {134--136},
  url = {http://dx.doi.org/10.15265/IY-2015-038},
  doi = {10.15265/IY-2015-038}
}

Abstract: Objective: This part II article about the ‘words of prevention’ presents
in a terminological way the content of ten current concepts used
in the prevention domain which are closely linked to quaternary prevention:
(1) overinformation, (2) overdiagnosis, (3) medically unexplained
symptoms, (4) overmedicalisation, (5) incidentaloma, (6) overscreening,
(7) overtreatment, (8) shared decision making, (9) deprescribing,
and (10) disease mongering. Methods: with the support of the laboratory
team of the University of Rouen, France, which is dedicated to medical
terminology and semantic relationships, it was possible to utilize
a graphic user interface (called DBGUI) allowing the construction
of links for each of chosen terms, and making automatic links to
MeSH, if any. Those concepts are analyzed in their environment in
current literature, as well as in their MeSH counterparts, if any,
and related semantic online terminologies. Results and Discussion:
The rules in terminological development aspire to cover the whole
field of a concept and in the meantime, it helps to avoid the noise
due to proxy and not exactly related issues. This refers to exhaustivity
and specificity in information retrieval. Our finds show that referring
to MeSH only in information retrieval in General Practice/Family
medicine can induce much noise and poor adequacy to the subject investigated.
Conclusion: Gathering concepts in specially prepared terminologies
for further development of ontologies is a necessity to enter in
the semantic web area and the era of distributed data.
BibTeX:
@article{Jamoulle2015,
  author = {Jamoulle, Marc and Gavilan, Enrique and Cardoso, Raquel Val and Mariño, Maria Ana and Pizzanelli, Miguel and Grosjean, Julien and Darmoni, Stefan},
  title = {The words of prevention, part {II}: ten terms in the realm of quaternary prevention},
  month = {April},
  journal = {Revista Brasileira de Medicina de Família e Comunidade},
  year = {2015},
  volume = {10},
  number = {35},
  pages = {1-11},
  url = {http://orbi.ulg.ac.be/handle/2268/176757},
  doi = {10.5712/rbmfc10(35)1063}
}

Abstract: New tools in data management have emerged in the last decade, which
are going to revolutionize electronic health records and health information
systems. Family practitioners are the first, main and continuous
contact with the patient. They are the source and endpoint of the
circle of information, generated by judicious medical documentation
and smart secondary use of medical data. This article is an introduction
to health terminologies, ontologies, semantic data, and linked open
data, all expressions used by computer scientists, preparing themselves
for the next step: semantic web for health care data.
BibTeX:
@article{Jamoulle2015b,
  author = {Jamoulle, Marc and Stichele, Vander and H, Robert and Cardillo, Elena and Roumier, Joseph and Grosjean, Julien and Darmoni, Stefan},
  title = {Semantic {Web} and the {Future} of {Health} {Care} {Data} in {Family} {Practice}},
  month = {December},
  journal = {Merit Research Journal of Medicine and Medical Sciences},
  year = {2015},
  volume = {3},
  number = {12},
  pages = {586-594},
  url = {http://orbi.ulg.ac.be/handle/2268/189292}
}

Abstract: Systemic sclerosis (SSc) has a complex pathogenesis. Although, there
is a growing evidence that environmental factors have an impact on
alterations and modulation of epigenetic determinants, resulting
in SSc onset and progression. A marked correlation has thus been
found between SSc onset and occupational exposure to crystalline
silica and the following organic solvents: white spirit, aromatic
solvents, chlorinated solvents, trichloroethylene, and ketones; the
risk associated with high cumulative exposure to silica and organic
solvents further appears to be strongly increased in SSc. Altogether,
occupational exposure should be systematically checked in all SSc
patients at diagnosis, as (1) exposed patients seem to develop more
severe forms of SSc and (2) the identification of the occupational
agents will allow its interruption, which may lead to potential improvement
of SSc outcome. By contrast, based on current published data, there
is insufficient evidence that exposure to other chemical agents (including
notably pesticides as well as personal care such as silicone and
hair dye), physical agents (ionizing radiation, ultraviolet radiation,
electric and magnetic fields), and biological agents (infections
and diet, foods, and dietary contaminants) is a causative factor
of SSc. Further investigations are still warranted to identify other
environmental factors that may be associated with SSc onset and progression.
BibTeX:
@article{Marie2015a,
  author = {Marie, Isabelle and Gehanno, Jean-Francois},
  title = {Environmental risk factors of systemic sclerosis.},
  month = {September},
  journal = {Seminars in immunopathology},
  year = {2015},
  volume = {37},
  number = {5},
  pages = {463--473},
  doi = {10.1007/s00281-015-0507-3}
}

Abstract: BACKGROUND: Occupational exposure is reported as playing a substantial
causative role in systemic sclerosis (SSc). OBJECTIVE: We sought
to compare the characteristics of SSc in patients with and without
occupational exposure to crystalline silica/solvents. METHODS: In
all, 142 patients with SSc were enrolled in this prospective study.
An expert committee performed blind evaluation of occupational exposure
to crystalline silica/solvents. RESULTS: Patients exposed to crystalline
silica more often exhibited: diffuse cutaneous SSc (P = .02), digital
ulcers (P = .05), interstitial lung disease (P = .0004), myocardial
dysfunction (P = .006), and cancer (P = .06). Patients exposed to
solvents more frequently developed: diffuse cutaneous SSc (P = .001),
digital ulcers (P = .01), interstitial lung disease (P = .02), myocardial
dysfunction (P = .04), and cancer (P = .003); in addition, these
patients were more frequently anti-Scl 70 positive and anticentromere
negative. Under multivariate analysis, significant factors for SSc
associated with exposure to silica/solvents were: male gender (odds
ratio 19.31, 95% confidence interval 15.34-69.86), cancer (odds
ratio 5.97, 95% confidence interval 1.55-23.01), and digital ulcers
(odds ratio 2.42, 95% confidence interval 1.05-5.56). LIMITATIONS:
The cohort originated from a single geographic region. CONCLUSION:
Occupational exposure to crystalline silica/solvents is correlated
with more severe forms of SSc characterized by: diffuse cutaneous
involvement, interstitial lung disease, general microangiopathy (digital
ulcers and myocardial dysfunction), and association with cancer.
Occupational exposure should be systematically checked in all patients
with SSc, as exposed patients seem to develop more severe forms of
SSc.
BibTeX:
@article{Marie2015,
  author = {Marie, Isabelle and Menard, Jean-Francois and Duval-Modeste, Anne-Benedicte and Joly, Pascal and Dominique, Stephane and Bravard, Pierre and Noel, David and Gehanno, Jean-Francois and Bubenheim, Michael and Benichou, Jacques and Levesque, Herve},
  title = {Association of occupational exposure with features of systemic sclerosis.},
  month = {March},
  journal = {Journal of the American Academy of Dermatology},
  year = {2015},
  volume = {72},
  number = {3},
  pages = {456--464},
  doi = {10.1016/j.jaad.2014.11.027}
}

Abstract: Though there are common variations of the internal jugular vein (IJV),
fenestrations are extremely rare. The lateral branch of the accessory
nerve classically goes through the fenestration. We report a case
of an empty fenestration of the IJV that was discovered during clearance
of cervical lymph nodes. Original operative and radiographic images
are shown.
BibTeX:
@article{Pegot2015,
  author = {Pegot, Alexandre and Guichard, Benjamin and Peron, Jean-Marc and Trost, Olivier},
  title = {Empty fenestration of the internal jugular vein: a rare phenomenon.},
  month = {January},
  journal = {The British journal of oral \& maxillofacial surgery},
  year = {2015},
  volume = {53},
  number = {1},
  pages = {78--80},
  doi = {10.1016/j.bjoms.2014.09.005}
}

BibTeX:
@article{Rollin2015,
  author = {Rollin, L and Griffon, N and Darmoni, SJ and Gehanno, JF},
  title = {Influence of author's affiliation and funding sources on the results of cohort studies on occupational cancer},
  month = {March},
  journal = {American Journal of Industrial Medicine},
  year = {2015},
  volume = {59},
  number = {3},
  pages = {221–226},
  doi = {10.1002/ajim.22549}
}

Abstract: To summarize excellent current research in the field of Bioinformatics
and Translational Informatics with application in the health domain
and clinical care.We provide a synopsis of the articles selected
for the IMIA Yearbook 2015, from which we attempt to derive a synthetic
overview of current and future activities in the field. As last year,
a first step of selection was performed by querying MEDLINE with
a list of MeSH descriptors completed by a list of terms adapted to
the section. Each section editor has evaluated separately the set
of 1,594 articles and the evaluation results were merged for retaining
15 articles for peer-review.The selection and evaluation process
of this Yearbook's section on Bioinformatics and Translational Informatics
yielded four excellent articles regarding data management and genome
medicine that are mainly tool-based papers. In the first article,
the authors present PPISURV a tool for uncovering the role of specific
genes in cancer survival outcome. The second article describes the
classifier PredictSNP which combines six performing tools for predicting
disease-related mutations. In the third article, by presenting a
high-coverage map of the human proteome using high resolution mass
spectrometry, the authors highlight the need for using mass spectrometry
to complement genome annotation. The fourth article is also related
to patient survival and decision support. The authors present datamining
methods of large-scale datasets of past transplants. The objective
is to identify chances of survival.The current research activities
still attest the continuous convergence of Bioinformatics and Medical
Informatics, with a focus this year on dedicated tools and methods
to advance clinical care. Indeed, there is a need for powerful tools
for managing and interpreting complex, large-scale genomic and biological
datasets, but also a need for user-friendly tools developed for the
clinicians in their daily practice. All the recent research and development
efforts contribute to the challenge of impacting clinically the obtained
results towards a personalized medicine.
BibTeX:
@article{Soualmia2015b,
  author = {Soualmia, L. F. and Lecroq, T.},
  title = {Bioinformatics Methods and Tools to Advance Clinical Care. Findings from the Yearbook 2015 Section on Bioinformatics and Translational Informatics.},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = {Health, 1, rue de Germont, Cour Leschevin porte 21, 76031 Rouen Cedex, France, Tel : +33 232 885 869, E-mail: Lina.Soualmia@chu-rouen.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {170--173},
  url = {http://dx.doi.org/10.15265/IY-2015-026},
  doi = {10.15265/IY-2015-026}
}

BibTeX:
@article{Toubiana2015,
  author = {Toubiana, L. and Griffon, N.},
  title = {Modelling, Simulation and Social Network Data: What's New for Public Health and Epidemiology Informatics?},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = {, 15, rue de l'École de Médecine, 75006 Paris, France, Tel: +33 1 44 27 91 97, E-mail: Laurent.toubiana@inserm.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {216--219},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587051/pdf/ymi-10-0216.pdf},
  doi = {10.15265/IY-2015-031}
}

Abstract: In April 2013, the Strategic Advisory Group of Experts (SAGE) on immunization stated that a single dose of yellow fever (YF) vaccine is sufficient in the general population to confer a lifelong protection against YF. When the period of validity of the International Certificate of Vaccination (ICV) will be extended to a lifetime in June 2016, no booster dose will be needed. The objective of this prospective study was to determine the potential impact of the SAGE recommendations on the vaccination activity of our travel clinics. We showed that among 1,037 subjects seen in our three travel clinics for a YF vaccination in 2013, about 32.3% went for a booster dose that is no longer useful according to the SAGE. A drop in vaccination activity has to be expected by travel clinics in the next years, and changes in daily exercise have to be anticipated, as YF vaccination is a large part of the regular work of many healthcare providers specialized in travel medicine.
BibTeX:
@article{Wyplosz2015,
  author = {Wyplosz, Benjamin and Leroy, Jean-Philippe and Derradji, Ouda and Consigny, Paul-Henri},
  title = {No booster dose for yellow fever vaccination: what are the consequences for the activity of vaccination in travel clinics?},
  journal = {Journal of travel medicine},
  year = {2015},
  volume = {22},
  pages = {140--141},
  doi = {10.1111/jtm.12173}
}

Abstract: Intérêts de la spirométrie en soins primairesLa spirométrie est une
exploration de la fonction respiratoire réalisable en cabinet de
médecine générale. Elle permet de diagnostiquer un trouble ventilatoire
obstructif (TVO), de mesurer sa sévérité et de suivre son évolution
avec ou sans traitement. Elle donne également des arguments en faveur
d’un trouble ventilatoire restrictif (TVR) permettant de proposer
des explorations spécialisées complémentaires. Les professionnels
de santé de soins primaires utilisent la spirométrie principalement
pour le diagnostic et le suivi de l’asthme et de la bronchopneumopathie
chronique obstructive (BPCO). La spirométrie fait partie de la démarche
diagnostique face à un patient symptomatique (toux ou expectoration
chroniques, dyspnée, sibilants).Asthme et BPCO : deux maladies prévalentes
En France, 9 % des enfants et 6 % des adultes sont asthmatiques1.
Diagnostiquer l’asthme permet d’instaurer le traitement médicamenteux
recommandé afin d’améliorer les symptômes, la qualité de vie, la
fréquence des exacerbations et la mortalité2.
BibTeX:
@article{Bouchez2015,
  author = {Bouchez, T and Chapron, A and Guihard, H and Thebault, JL and Schuers, M. and Darmon, D},
  title = {La spirométrie en cabinet de médecine générale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {120},
  pages = {176--81}
}

BibTeX:
@article{Crampon2015,
  author = {Crampon, F. and Eliezer, M. and Choussy, O. and Hardy, H. and Trost, O.},
  title = {A pathognomonic {CT} of the parotid gland.},
  month = {February},
  journal = {Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale},
  year = {2015},
  volume = {116},
  number = {1},
  pages = {e1--2},
  doi = {10.1016/j.revsto.2014.10.001}
}

Abstract: L’objectif attribué par la loi aux services de santé au travail est
d’éviter toute altération de la santé des travailleurs du fait de
leur travail mais également de contribuer au maintien dans l’emploi
des travailleurs. À cette fin, les services de santé au travail conduisent,
entre autres, des actions de surveillance systématique de la santé,
dans une optique de dépistage pour des pathologies en lien avec le
travail ou pouvant avoir un retentissement sur le travail. Nous laisserons
de côté la surveillance médicale renforcée, qui fait l’objet de recommandations
spécifiques. Dans le cadre d’un suivi de santé non motivé par une
exposition à des facteurs de risques professionnels, la question
posée est celle de l’intérêt d’un examen clinique régulier, assorti
ou non d’examens paracliniques. Si la littérature est limitée dans
le domaine de la santé au travail, elle est abondante dans le champ
de la santé publique et permet d’affirmer que ce type de suivi systématique
n’apporte pas de bénéfice mesurable en termes de limitation de la
mortalité ou de la morbidité, globale, cardiovasculaire ou par cancer
[1] . Il n’est de plus pas dénué d’effets secondaires, auxquels il
faut ajouter le risque d’exclusion propre à la santé au travail.
Il convient toutefois de souligner que l’intérêt de ce type de rendez-vous
de santé régulier n’a pas été évalué en termes de maintien de la
relation, ou de la confiance, entre le patient/salarié et le médecin.
L’intérêt d’un dépistage étant lié à la fréquence de la maladie dans
la population qui bénéficie du dépistage, il peut être plus important
dans certains groupes exposés à des nuisances professionnelles. On
peut ainsi citer deux exemples ayant fait l’objet de recommandations
récentes de la part de la Société française de médecine du travail.
Chez les sujets exposés à des allergènes, il est recommandé de procéder
au dépistage de la rhinite professionnelle en particulier pendant
l’apprentissage ou les deux premières années d’exposition [2] . Chez
les travailleurs postés et/ou de nuit, il est recommandé de dépister
une privation chronique de sommeil et des épisodes de somnolence
ainsi que de mesurer le poids et la tension de façon annuelle [3]
. Il est intéressant de noter que ces dépistages reposent principalement
sur l’interrogatoire, et peuvent donc impliquer l’infirmier de santé
au travail. Le rendez-vous de santé servant de support au dépistage
peut également être l’occasion d’une information sur les risques
professionnels, comme cela a été proposé récemment chez les salariés
exposés à de la manutention manuelle de charges [4] . Enfin, la notion
de dépistage peut également être élargie aux conditions de travail
et aux expositio...
BibTeX:
@article{Gehanno2015,
  author = {Gehanno, J.F. and Larchevesque, J.Y.},
  title = {État des connaissances sur les dépistages en santé au travail},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2015},
  volume = {76},
  number = {4},
  pages = {407--407},
  doi = {10.1016/j.admp.2015.04.042}
}

Abstract: Contexte. Depuis 2007, 130 chefs de clinique de médecine générale
ont été nommés et 13 d’entre eux sont devenus maîtres de conférences
des universités par la voie du concours. La création de la soussection
53-03 propre à la médecine générale en mars 2015 paraissait une occasion
pertinente de décrire l’activité des chefs de clinique.Objectif.
Décrire les activités de soins, d’enseignement et de recherche des
chefs de clinique de médecine générale en activité en octobre 2014.Méthode.
Enquête descriptive par questionnaire auto-administré en ligne. Les
activités de soins, d’enseignement et de recherche ont été décrites
: organisation, contenu, formation, satisfaction et perspectives.Résultats.
Parmi les 95 chefs de clinique de médecine générale en poste à la
date de l’étude, 75 (79 ont répondu : âge moyen 32 ans ; sex-ratio
F/H 2,4. Ils consacraient respectivement un nombre médian de 5, 2
et 3 demi-journées par semaine aux activités de soins, d’enseignement
et de recherche. L’activité de soins était majoritairement libérale
(73 – dont 39 % en structure pluriprofessionnelle – à raison
de 50 consultations par semaine. Le nombre de patients les ayant
déclarés médecin traitant augmentait significativement au cours du
clinicat. L’activité d’enseignement concernait surtout le troisième
cycle (médiane : 86 heures par an). Un tiers des chefs de clinique
étaient maîtres de stage des universités. L’activité de recherche
augmentait significativement au cours du clinicat. La majorité des
chefs de clinique avaient une formation à la recherche et un projet
en cours (45 % au sein d’une unité labellisée). Les thématiques
de recherche étaient en rapport avec le champ disciplinaire.Conclusion.
Au cours du clinicat, la stabilisation – voire le renforcement –
des activités de soins et de recherche s’accompagne d’un investissement
marqué dans l’activité d’enseignement. Cette dynamique doit se poursuivre,
pour un rôle de plus en plus modélisant de l’enseignant-chercheur
en médecine générale.
BibTeX:
@article{Laporte2015,
  author = {Laporte, C. and Barais, M and Bouchez, T and Darmon, D and Dibao-Dina, C. and Frappé, P. and Saint-Lary, O. and Schuers, M. and Gelly, J.},
  title = {Activité des chefs de clinique en médecine générale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {122},
  pages = {283--94}
}

BibTeX:
@article{Leroy2015,
  author = {Leroy, Jean-Philippe},
  title = {Vaccin contre la fièvre jaune : une protection à vie ?},
  month = {October},
  journal = {La Revue du praticien},
  year = {2015},
  volume = {65},
  pages = {1015--1017}
}

Abstract: Dans le domaine de la santé au travail, de très nombreuses situations
sont à l’origine de conflits éthiques. À titre d’exemple, les adaptations
ou les maintiens dans l’emploi pour des problèmes de santé font intervenir
non seulement les employeurs et leurs employés mais également les
médecins du travail dont les déterminations d’aptitude médicale au
poste ont des conséquences socioprofessionnelles majeures. Si on
remonte à sa création, depuis 1946, la réglementation française relative
à la santé au travail a fait l’objet de multiples modifications.
À ce titre, en 2012, une nouvelle réforme de la médecine du travail
a été à l’origine d’une réapparition de questionnements de pratiques
chez les personnes impliquées par ces changements. Aussi, par l’intermédiaire
d’un recueil de situations réelles, nous avons voulu apporter un
regard pluridisciplinaire sur les dilemmes éthiques encore plus mis
en lumière par cette évolution réglementaire dans un monde du travail
qui traverse actuellement une période économique tendue.
BibTeX:
@article{Lodde2015,
  author = {Loddé, B. and Gehanno, J.-F. and Jousset, D. and Pougnet, R. and Durand-Moreau, Q. and Dewitte, J.-D.},
  title = {Conflits éthiques en {Santé} au {Travail} : quelques particularités de la réglementation française opposées à des difficultés pratiques de mises en œuvre},
  journal = {Ethique et Sante},
  year = {2015},
  volume = {12},
  number = {2},
  pages = {138--144},
  doi = {10.1016/j.etiqe.2014.12.001}
}

Abstract: Il n’existe pas à l’heure actuelle de réel consensus concernant les
modalités du dépistage du risque de mort subite d’origine cardiovasculaire
chez les sportifs de moins de 35 ans. La question de l’adjonction
systématique d’un électrocardiogramme fait notamment débat. D’un
côté, l’électrocardiogramme vient apporter de la validité à un examen
physique qui en manque cruellement. L’expérience italienne, la plus
connue, montre aussi des résultats spectaculaires. Entre 1979 et
2004, l’incidence des morts subites chez les sportifs a chuté de
près de 90 %. D’un autre côté, l’incidence des morts subites chez
les jeunes sportifs en France est très faible, de l’ordre de 0,5
à 1 cas pour 100 000 personnes par an, soit moins de 50 cas annuels.
De plus, la réalisation systématique d’un ECG, même interprété par
un professionnel expérimenté, expose à un taux significatif de faux
positifs. Cette faible spécificité n’est pas sans conséquences pour
le patient. Enfin, l’implémentation d’un programme de dépistage systématique
du risque de mort subite par électrocardiogramme en France engendrerait
des coûts majeurs, en termes d’équipement, de formation des professionnels
et d’honoraires. À ce jour, il ne semble pas exister suffisamment
de données permettant de justifier l’ajout systématique de l’ECG
à la procédure de dépistage du risque de mort subite chez le jeune
sportif.
BibTeX:
@article{Quibel2015,
  author = {Quibel, T and Valy, G and Schuers, M.},
  title = {Dépistage du risque de mort subite chez le sportif : quelle place pour l’{ECG} ?},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {119},
  pages = {77--82}
}

Abstract: Contexte Afin d’aider les patients atteints de cancer à reprendre
le travail, une plateforme multidisciplinaire médico-socio-psychologique
d’aide à la reprise du travail après un cancer a été créée en 2006 en
Haute-Normandie. Objectifs Décrire l’organisation et les retours
de cette plateforme. Méthode Les 3 intervenants ont fait part de
leurs observations. Les caractéristiques des consultants, les conseils
apportés et le devenir des patients ont été analysés via l’étude
des dossiers et un questionnaire complété par le patient. Résultats
Cent cinquante patients, atteints principalement de cancer du sein
(64 , ont consulté pour des problématiques de maintien dans l’emploi
(3/4) ou de recherche d’emploi (1/4). Le taux de reprise, évalué
à partir de questionnaires adressés aux patients en 2011, était de
64 % (IC 95 % = 54–73), en moyenne 7 mois (IC 95 % = 5–9) après
la 1 re  consultation de reprise du travail. Quatre-vingt-treize
pour cent des patients estimaient que la plateforme leur avait été
utile. Cette plateforme permet une transition entre les milieux de
soins et du travail, oriente le patient vers le bon interlocuteur
compte tenu de la situation et apporte des conseils spécifiques adaptés
à la pathologie ainsi qu’un avis spécialisé à des patients n’en bénéficiant
pas habituellement.
BibTeX:
@article{Rollin2015a,
  author = {Rollin, Lætitia and De Blasi, Géraldine and Boucher, Line and Gehanno, Jean-François},
  title = {Intérêts d’une consultation spécialisée d’aide à la reprise du travail après cancer},
  journal = {Bulletin du cancer},
  year = {2015},
  volume = {102},
  number = {2},
  pages = {182--189},
  doi = {10.1016/j.bulcan.2014.06.001}
}

BibTeX:
@inproceedings{Cabot2015a,
  author = {Cabot, Chlo{\'e} and Soualmia, Lina F and Grosjean, Julien and Lelong, Romain and Darmoni, St{\'e}fan J},
  title = {Integrating and Retrieving Clinical and Omic Data in Electronic Health Records},
  booktitle = {7th International Workshop on Knowledge Representation for Health Care (KRH4C) and 8th International Workshop on Process-oriented Information Systems in Healthcare (ProHealth)},
  year = {2015},
  pages = {154-159},
  url = {https://www.researchgate.net/profile/Lina_Soualmia/publication/280066101_Integrating_and_Retrieving_Clinical_and_Omic_Data_in_Electronic_Health_Records/links/55a7a47408aeceb8cad65695.pdf}
}

BibTeX:
@inproceedings{Chebil2015,
  author = {Chebil, W and Soualmia, LF and Omri, MN and Darmoni, SJ},
  title = {Biomedical Concepts Extraction with a Possibilistic Network and a Vector Space Model},
  booktitle = {15th Conference on Artificial Intelligence in MEdicine, AIME'15},
  year = {2015},
  series = {Lecture Notes in Artificial Intelligence},
  volume = {9105},
  pages = {227-231},
  doi = {10.1007/978-3-319-19551-3_29}
}

Abstract: The use of watermarking in the protection of medical relational databases
requires that the introduced distortion does not hinder records interpretation.
In this paper, we present the preliminary results of a watermarked
data quality evaluation protocol developed so as to analyze the perception
the practitioner has of the watermark. These results show that some
attributes are more appropriate for watermarking than others and
also that incoherent or unlikely records resulting from careless
watermarking are easily identified by an expert.
BibTeX:
@inproceedings{Franco-Contreras2015,
  author = {Franco-Contreras, Javier and Coatrieux, Gouenou and Massari, Philippe and Darmoni, Stefan and Cuppens-Boulahia, Nora and Cuppens, Frédéric and Roux, Christian},
  title = {Data quality evaluation in medical database watermarking.},
  booktitle = {MIE 2015},
  journal = {Stud Health Technol Inform},
  school = {Institut Mines-TELECOM, Mines Saint-Étienne, Saint-Étienne, 62362 France.},
  year = {2015},
  volume = {210},
  pages = {276--280}
}

BibTeX:
@inproceedings{Grouin2015a,
  author = {Grouin, C and Griffon, N and Névéol, A},
  title = {Is it possible to recover personal health information from an automatically de-identified corpus of French EHRs?},
  booktitle = {Proc of LOUHI - the Sixth International Workshop on Health Text Mining and Information Analysis},
  address = {Lisbon, Portugal},
  year = {2015}
}

Abstract: Suspected adverse drug reactions (ADR) reported by patients through
social media can be a complementary tool to already existing ADRs
signal detection processes. However, several studies have shown that
the quality of medical information published online varies drastically
whatever the health topic addressed. The aim of this study is to
use an existing rating tool on a set of social network web sites
in order to assess the capabilities of these tools to guide experts
for selecting the most adapted social network web site to mine ADRs.First,
we reviewed and rated 132 Internet forums and social networks according
to three major criteria: the number of visits, the notoriety of the
forum and the number of messages posted in relation with health and
drug therapy. Second, the pharmacist reviewed the topic-oriented
message boards with a small number of drug names to ensure that they
were not off topic. Six experts have been chosen to assess the selected
internet forums using a French scoring tool: Net scoring. Three different
scores and the agreement between experts according to each set of
scores using weighted kappa pooled using mean have been computed.Three
internet forums were chosen at the end of the selection step. Some
criteria get high score (scores 3-4) no matter the website evaluated
like accessibility (45-46) or design (34-36), at the opposite some
criteria always have bad scores like quantitative (40-42) and ethical
aspect (43-44), hyperlinks actualization (30-33). Kappa were positives
but very small which corresponds to a weak agreement between experts.The
personal opinion of the expert seems to have a major impact, undermining
the relevance of the criterion. Our future work is to collect results
given by this evaluation grid and proposes a new scoring tool for
Internet social networks assessment.
BibTeX:
@inproceedings{Katsahian2015,
  author = {Katsahian, Sandrine and {Simond Moreau}, Erica and Leprovost, Damien and Lardon, Jeremy and Bousquet, Cedric and Kerdelhué, Gaétan and Abdellaoui, Redhouane and Texier, Nathalie and Burgun, Anita and Boussadi, Abdelali and Faviez, Carole},
  title = {Evaluation of Internet Social Networks using Net scoring Tool: A Case Study in Adverse Drug Reaction Mining.},
  booktitle = {MIE 2015},
  journal = {Stud Health Technol Inform},
  school = {Kappa Santé, Paris, France.},
  year = {2015},
  volume = {210},
  pages = {526--530}
}

BibTeX:
@inproceedings{Merabti2015,
  author = {Merabti, T and Lelong, R and Darmoni, SJ},
  title = {InfoRoute: the CISMeF Context-specific Search Algorithm},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {544-8}
}

Abstract: Consequences of the computerization of laboratory and radiology information
system (LIS and RIS) are not well documented. The aim of this study
was to evaluate the impact of computerization of LIS and RIS of four
hospitals on performance and quality of care. The study was divided
into three phases. First, the subprocesses and information flows
of LIS and RIS were described. Then, a literature review was performed
in order to identify the indicators used to assess the impact of
computerization. Finally, comparisons were made between 2 hospitals.
Using the initial framework, each partner described its process mapping
concerning LIS and RIS. The review identified a wide panel of indicators.
Only 41 were useful to assess the impact of information systems.
For each two by two comparison, lists of relevant indicators have
been selected from the identified indicators and according to the
process mapping comparison. Two by two comparisons have to be completed.
Eventually, these indicators may be integrated in the quality process
of hospital information systems.
BibTeX:
@inproceedings{Schuers2015a,
  author = {Schuers, M and Joulakian, M and Griffon, N and Pachéco, J and Périgard, C and Lepage, E and Watbled, L and Massari, P and Darmoni, SJ},
  title = {Quality indicators from laboratory and radiology information systems},
  booktitle = {MEDINFO},
  journal = {Studies in Health Technology and Informatics},
  year = {2015},
  volume = {216},
  pages = {212-6},
  note = {PREPS EVAL-SI},
  doi = {10.3233/978-1-61499-564-7-212}
}

BibTeX:
@inproceedings{Soualmia2015a,
  author = {Soualmia, LF and Cabot, C and Dahamna, B and Darmoni, SJ},
  title = {SIBM at CLEF e-Health Evaluation Lab 2015},
  booktitle = {proceedings of CLEF 2015 - Conference and Labs of the Evaluation Forum},
  year = {2015},
  series = {CEUR Workshop Proceedings},
  volume = {1391},
  url = {http://ceur-ws.org/Vol-1391/125-CR.pdf}
}

Abstract: In this paper, a method based on pre-defined patterns, which rewrites
natural language queries into a multi-layer, flexible, scalable and
object-oriented query language, is presented. The method has been
conceived to assist physicians in their search for clinical information
in an Electronic Health Records system. Indeed, the query language
of the system being difficult to handle for physicians, this method
allows querying using natural language vs. using dedicated object-oriented
query language. The information extraction method that has been developed
can be seen as a named entity recognition system based on regular
expressions that tags pieces of the query. The patterns are constructed
recursively from the initial natural language query and from atomic
patterns that correspond to the entities, the relationships and the
constraints of the underlying model representing Electronic Health
Records. Further evaluation is needed, but the preliminary results
obtained by testing a set of natural language queries are very encouraging.
BibTeX:
@inproceedings{Soualmia2015,
  author = {Soualmia, LF and Lelong, R and Dahamna, B and Darmoni, SJ},
  title = {Rewriting Natural Language Queries Using Patterns},
  booktitle = {proceedings of MRMD},
  publisher = {Springer-Verlag},
  year = {2015},
  series = {Lecture Notes in Computer Science},
  volume = {9059},
  pages = {40-53},
  doi = {10.1007/978-3-319-24471-6_4}
}

BibTeX:
@inproceedings{Cabot2015,
  author = {Cabot, C and Soualmia, LF and Darmoni, SJ},
  title = {Intégration de données cliniques et omiques pour la recherche d’information dans le Dossier Patient Informatisé},
  booktitle = {Actes des 26èmes Journées Francophones d’Ingénierie des Connaissances (IC), associées à la Plateforme de l’Association Française pour l’Intelligence Artificielle},
  address = {Rennes, France},
  year = {2015},
  pages = {183-193},
  url = {https://hal.archives-ouvertes.fr/hal-01179292/}
}

BibTeX:
@inproceedings{Grouin2015,
  author = {Grouin, C and Griffon, N and Névéol, A},
  title = {Étude des risques de réidentification des patients à partir d'un corpus désidentifié de comptes-rendus cliniques en français},
  booktitle = {Atelier ETeRNAL Ethique et TRaitemeNt Automatique des Langues},
  address = {Caen, France},
  month = {Juin},
  year = {2015},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/pdf/Giquel2013.pdf}
}

BibTeX:
@inproceedings{Lelong2015a,
  author = {Lelong, R and Cabot, C and Merabti, T and Grosjean, J and Joulakian, M and Griffon, N and Dahamna, B and Massari, P and Darmoni, SJ},
  title = {Information Retrieval in Electronic Health Records Using a Multiple Layer Query Language},
  booktitle = {RITS},
  year = {2015},
  note = {projet RAVEL ANR TecSan}
}

BibTeX:
@inproceedings{Gicquel2015,
  author = {Gicquel, Q and Tvardik, N and Bouvry, C and Kergourlay, I and Bittar, A and Segond, F and Darmoni, SJ and Metzger, MH},
  title = {Annotation methods to develop and evaluate an expert system based on natural langage processing in electronic medical records},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {1067},
  doi = {10.3233/978-1-61499-564-7-1067}
}

BibTeX:
@inproceedings{Henry2015,
  author = {Henry, V and Grosjean, J and Soualmia, LF and Bandrowski, A and Gonzalez, B and Darmoni, SJ and Desfeux, A},
  title = {OMIC-Onto : une ressource pour l'indexation et la recherche d'outils omiques},
  booktitle = {Actes des Journées Ouvertes en Bioinformatique, Informatique et Mathématiques (JOBIM)},
  address = {Clermont-Ferrand, France},
  month = {Juillet},
  year = {2015}
}

Abstract: ICPC is available in the HeTOP cross-lingual terminology portal (URL:
www.hetop.eu) [1] in 19 languages, mostly European (e.g. Spanish,
Portuguese) but also in Japanese or Mandarin. The HeTOP interface
has been also translated in 10 languages, including by Wonca colleagues
(in Turkish, Vietnamese and Romanian). This is very important for
non-English speakers to access a health Web site in his/her native
language. Thanks to a partial manual mapping between ICPC2 and MeSH,
it is now also possible to query PubMed from 20% of ICPC2 codes.
This task is time consuming as in lot of cases, the mapping is 1
to N (one ICPC code generates several MeSH terms; e.g. the ICPC term
"diverticular disease" is mapped to two MeSH terms " diverticulosis,
colonic" and " diverticulitis". HeTOP currently contains 56 health
terminologies and ontologies (only 17 are included in UMLS as most
of them are French terminologies), 1,951,834 concepts, 6,636,000
terms, 8,023,181 relations and 1,340,855 relations. Overall, HeTOP
contains 108 millions of SPARQL triplets. These figures underlines
the possible application of the so called "health big data". Overall,
the number of distinct UMLS concepts with at least one French translation
in UMLS (MeSH, MedDRA, WHOART, ICPC) is 45,405 vs. 317,539 in HeTOP.
1. Grosjean, J; Merabti, T; Griffon, N; Dahamna, B & Darmoni, SJ.
Teaching medicine with a terminology/ontology portal. Stud Health
Technol Inform 2012:180;949-53.
BibTeX:
@inproceedings{Jamoulle2015a,
  author = {Jamoulle, Marc and Pizzanelli, Miguel and Grosjean, Julien and Kerdelhue, Gaetan and Darmoni, Stefan},
  title = {International {Classification} of {Primary} {Care} in a cross-lingual terminology portal},
  month = {March},
  year = {2015},
  note = {Best Poster Award},
  url = {http://orbi.ulg.ac.be/handle/2268/179499}
}

BibTeX:
@inproceedings{Kerdelhue2015,
  author = {Kerdelhué, G and Grosjean, J and Darmoni, SJ \& le consortium du projet BDBfr},
  title = {LiSSa : Une nouvelle base de données de la littérature Scientifique en Santé en langue française},
  booktitle = {7ème journée ITS / 2ème journée innovation},
  address = {Montpellier, France},
  month = {Décembre},
  year = {2015},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2015/12/ITS_poster_2015_lissa.pdf}
}

BibTeX:
@inproceedings{Merabti2015a,
  author = {Merabti, T and Grosjean, J and Rodrigues, JM and Darmoni, SJ},
  title = {Translating ICD-11 into French using lexical-based approach: a preliminary study},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {1036}
}

BibTeX:
@inproceedings{Schuers2015,
  author = {Schuers, M},
  title = {Interroger Medline en français : c'est possible !},
  booktitle = {CMGF Paris},
  year = {2015}
}

BibTeX:
@inproceedings{Schuers2015b,
  author = {Schuers, M and Griffon, N and Kerdelhué, G and Grosjean, J and Darmoni, SJ},
  title = {Évaluation de l'association entre langue et qualité des requêtes pour la recherche bibliographique: essai randomisé},
  booktitle = {4ème journée de l'IRIB},
  address = {Rouen, France},
  year = {2015}
}

Abstract: Electronic medical records (EHR) are a very important source of information
for secondary use as epidemiological analysis and health services
evaluation. The normalisation of the medical terms extracted from
medical documents is an essential step of the preprocessing. Its
quality partly depends on the medical terminologies available in
the corresponding language. The objective of this presentation is
to highlight the terminology needs for optimizing the data analysis
of medical documents in the context of care pathway evaluation.
BibTeX:
@inproceedings{Tvardik2015,
  author = {Tvardik, N and Bouvry, C and Kergoulay, I and Darmoni, SJ and Metzger, M},
  title = {The terminology needs for evaluation of care pathways},
  booktitle = {WHO - family of international classifications network annual meeting 2015},
  month = {October},
  year = {2015}
}