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2024


Abstract: Background
Current literature highlights the difficulty in identifying which pelvic floor muscle (PFM) functions are correlated with urinary incontinence (UI).
Aim
In this study, we compared parameters of PFM function (strength, endurance, tone, control, reaction, and/or coordination) according to continence status in women (presence or absence, type and/or severity of urinary incontinence).
Evidence acquisition
A systematic review was conducted following the 2020 PRISMA guidelines. Three databases (Pubmed, Web of Science, and LiSSa) were searched from inception to December 31, 2021. Assessment of risk of bias was performed using the Joanna Briggs Institute critical appraisal checklist.
Evidence synthesis
The initial research yielded 4733 studies. Forty-two studies met the inclusion criteria, including 4015 participants. No statistical association was found between PFM function and the presence or absence of UI, the different type of UI or the different levels of severity of UI. The heterogeneity in methodologies and analyzes of the results only with the P-value are important limitations of this review.
Conclusion
It appears that muscle function is not always associated with presence or absence of UI. No association is found between PFM function and type or severity of UI. These results reinforce the need to carry out a bio-psycho-social evaluation of UI that does not only focus on PFM functions. As such, the results reported herein can be considered a resource for more specific research.
Résumé
Contexte
La littérature actuelle souligne la difficulté d’identifier quelles fonctions des muscles du plancher pelvien (MPP) sont corrélées à l’incontinence urinaire (IU).
Objectif
Dans cette étude, nous avons comparé les paramètres de la fonction des muscles du plancher pelvien (force, endurance, tonus, contrôle, réaction et/ou coordination) en fonction du statut de continence des femmes (présence ou absence, type et/ou sévérité de l’incontinence urinaire).
Méthode
Une étude systématique a été réalisée conformément aux lignes directrices PRISMA 2020. Trois bases de données (Pubmed, Web of Science, et LiSSa) ont été consultées depuis le début jusqu’au 31 décembre 2021. L’évaluation du risque de biais a été réalisée à l’aide de la Joanna Briggs Institute critical appraisal checklist.
Résultats
La recherche initiale a donné lieu à 4733 études. Quarante-deux études répondaient aux critères d’inclusion, incluant 4015 participants. Aucune association statistique n’a été trouvée entre la fonction des MPP et la présence ou l’absence d’IU, les différents types d’IU ou les différents niveaux de sévérité de l’IU. L’hétérogénéité des méthodologies et l’analyse des résultats uniquement à l’aide de la valeur p sont des limites importantes de cette étude.
Conclusion
Il semble que la fonction musculaire ne soit pas toujours associée à la présence ou à l’absence d’IU. Aucune association n’a été trouvée entre la fonction des MPP et le type ou la gravité de l’IU. Ces résultats renforcent la nécessité de procéder à une évaluation bio-psycho-sociale de l’IU, qui ne se concentre pas uniquement sur la fonction des MPP. Les résultats rapportés ici peuvent être considérés comme une ressource pour des recherches plus spécifiques.
BibTeX:
@article{Audrain2024,
  author = {Audrain, Albane and Cornu, Jean Nicolas and Kerdelhue, Gaëtan and Combret, Yann and Steenstrup, Benoit},
  title = {Do pelvic floor muscle function parameters differ in women according to continence status? {A} systematic review},
  month = {March},
  journal = {The French Journal of Urology},
  year = {2024},
  volume = {34},
  number = {3},
  pages = {102592},
  url = {https://www.sciencedirect.com/science/article/pii/S2950393024000494},
  doi = {10.1016/j.fjurol.2024.102592}
}

Abstract: BACKGROUND: There are various Medical Subject Headings (MeSH) terms used to index general practice research, without consistency.
AIM: To understand how general practice-related research is indexed in the main general practice journals between 2011 and 2021, and to analyse the factors that influenced the choice of the general practice-related MeSH.
DESIGN AND SETTING: This was a quantitative bibliometric study conducted on MEDLINE.
METHOD: MeSH were selected according to the international definition of General Practice/Family Medicine: 'General Practice', 'Primary Health Care', 'Family Practice', 'General Practitioners', 'Physicians, Primary Care', and 'Physicians, Family'. Their use was studied from 2011 to 2021 on MEDLINE, reviewing the 20 general practice journals with the highest impact factors. A descriptive and analytical approach was used; the association of the country, journal, and year with the choice of general practice-related MeSH terms was analysed.
RESULTS: A total of 8514 of 150 286 articles (5.7 were using one of the general practice-related MeSH terms. The most used were 'Primary Health Care' (4648/9984, 46.6 and 'General Practice' (2841/9984, 28.5. A total of 80.0% (6172/7723) of the articles were related to the UK or US and 71.0% (6055/8514) of the articles came from four journals (BJGP, BMJ, Journal of General Internal Medicine, and Annals of Family Medicine). Two main country clusters emerged from the use of general practice-related MeSH: a British cluster mainly using 'General Practice' and an American cluster using 'Primary Health Care'. The journals also mainly differed in their used of these two MeSH terms.
CONCLUSION: Important variations in the indexation of general practice research were found. Researchers should consider combining 'Primary Health Care' and 'General Practice' in their PubMed searches to access all the general practice research, regardless of their country of origin.
BibTeX:
@article{Duguet2024,
  author = {Duguet, Théo and Ibanez, Gladys and Schuers, Matthieu and Lebeau, Jean-Pierre and Roser, Kristell and Gomes, Cécilia Saldanha and Cadwallader, Jean-Sébastien},
  title = {General practice-related {MeSH} terms in main journals: a bibliometric analysis from 2011 to 2021},
  month = {January},
  journal = {The British Journal of General Practice: The Journal of the Royal College of General Practitioners},
  year = {2024},
  pages = {BJGP.2023.0060},
  doi = {10.3399/BJGP.2023.0060}
}

Abstract: OBJECTIVES: Studies on the impact of long COVID on work capacity are increasing but are difficult to locate in bibliographic databases, due to the heterogeneity of the terms used to describe this new condition and its consequences. This study aims to report on the effectiveness of different search strategies to find studies on the impact of long COVID on work participation in PubMed and to create validated search strings.
METHODS: We searched PubMed for articles published on Long COVID and including information about work. Relevant articles were identified and their reference lists were screened. Occupational health journals were manually scanned to identify articles that could have been missed. A total of 885 articles potentially relevant were collected and 120 were finally included in a gold standard database. Recall, Precision, and Number Needed to Read (NNR) of various keywords or combinations of keywords were assessed.
RESULTS: Overall, 123 search-words alone or in combination were tested. The highest Recalls with a single MeSH term or textword were 23 and 90 respectively. Two different search strings were developed, one optimizing Recall while keeping Precision acceptable (Recall 98.3 Precision 15.9 NNR 6.3) and one optimizing Precision while keeping Recall acceptable (Recall 90.8 Precision 26.1 NNR 3.8).
CONCLUSIONS: No single MeSH term allows to find all relevant studies on the impact of long COVID on work ability in PubMed. The use of various MeSH and non-MeSH terms in combination is required to recover such studies without being overwhelmed by irrelevant articles.
BibTeX:
@article{Gehanno2024,
  author = {Gehanno, Jean-François and Thaon, Isabelle and Pelissier, Carole and Rollin, Laetitia},
  title = {Assessment of search strategies in {Medline} to identify studies on the impact of long {COVID} on workability},
  journal = {Frontiers in Research Metrics and Analytics},
  year = {2024},
  volume = {9},
  pages = {1300533},
  doi = {10.3389/frma.2024.1300533}
}

Abstract: BACKGROUND: Access to reliable and accurate digital health web-based resources is crucial. However, the lack of dedicated search engines for non-English languages, such as French, is a significant obstacle in this field. Thus, we developed and implemented a multilingual, multiterminology semantic search engine called Catalog and Index of Digital Health Teaching Resources (CIDHR). CIDHR is freely accessible to everyone, with a focus on French-speaking resources. CIDHR has been initiated to provide validated, high-quality content tailored to the specific needs of each user profile, be it students or professionals.
OBJECTIVE: This study's primary aim in developing and implementing the CIDHR is to improve knowledge sharing and spreading in digital health and health informatics and expand the health-related educational community, primarily French speaking but also in other languages. We intend to support the continuous development of initial (ie, bachelor level), advanced (ie, master and doctoral levels), and continuing training (ie, professionals and postgraduate levels) in digital health for health and social work fields. The main objective is to describe the development and implementation of CIDHR. The hypothesis guiding this research is that controlled vocabularies dedicated to medical informatics and digital health, such as the Medical Informatics Multilingual Ontology (MIMO) and the concepts structuring the French National Referential on Digital Health (FNRDH), to index digital health teaching and learning resources, are effectively increasing the availability and accessibility of these resources to medical students and other health care professionals.
METHODS: First, resource identification is processed by medical librarians from websites and scientific sources preselected and validated by domain experts and surveyed every week. Then, based on MIMO and FNRDH, the educational resources are indexed for each related knowledge domain. The same resources are also tagged with relevant academic and professional experience levels. Afterward, the indexed resources are shared with the digital health teaching and learning community. The last step consists of assessing CIDHR by obtaining informal feedback from users.
RESULTS: Resource identification and evaluation processes were executed by a dedicated team of medical librarians, aiming to collect and curate an extensive collection of digital health teaching and learning resources. The resources that successfully passed the evaluation process were promptly included in CIDHR. These resources were diligently indexed (with MIMO and FNRDH) and tagged for the study field and degree level. By October 2023, a total of 371 indexed resources were available on a dedicated portal.
CONCLUSIONS: CIDHR is a multilingual digital health education semantic search engine and platform that aims to increase the accessibility of educational resources to the broader health care-related community. It focuses on making resources "findable," "accessible," "interoperable," and "reusable" by using a one-stop shop portal approach. CIDHR has and will have an essential role in increasing digital health literacy.
BibTeX:
@article{Grosjean2024,
  author = {Grosjean, Julien and Benis, Arriel and Dufour, Jean-Charles and Lejeune, Émeline and Disson, Flavien and Dahamna, Badisse and Cieslik, Hélène and Léguillon, Romain and Faure, Matthieu and Dufour, Frank and Staccini, Pascal and Darmoni, Stéfan Jacques},
  title = {Sharing {Digital} {Health} {Educational} {Resources} in a {One}-{Stop} {Shop} {Portal}: {Tutorial} on the {Catalog} and {Index} of {Digital} {Health} {Teaching} {Resources} ({CIDHR}) {Semantic} {Search} {Engine}},
  month = {March},
  journal = {JMIR medical education},
  year = {2024},
  volume = {10},
  pages = {e48393},
  doi = {10.2196/48393}
}

Abstract: SaNuRN is a five-year project by the University of Rouen Normandy (URN) and the Côte d’Azur University (CAU) consortium to optimize digital health education for medical and paramedical students, professionals, and administrators. The project includes a skills framework, training modules, and teaching resources. In 2027, SaNuRN is expected to train a significant portion of the 400,000 health and paramedical professions students at the French national level. Our purpose is to give a synopsis of the SaNuRN initiative, emphasizing its novel educational methods and how they will enhance the delivery of digital health education. Our goals include showcasing SaNuRN as a comprehensive program consisting of a proficiency framework, instructional modules, and educational materials and explaining how SaNuRN is implemented in the participating academic institutions. SaNuRN is a project aimed at educating and training health-related and paramedics students in digital health. The project results from a cooperative effort between URN and CAU, covering four French departments. The project is based on the French National Referential on Digital Health (FNRDH), which defines the skills and competencies to be acquired and validated by every student in the health, paramedical, and social professions curricula. The SaNuRN team is currently adapting the existing URN and CAU syllabi to FNRDH and developing short-duration video capsules of 20 to 30 minutes to teach all the relevant material. The project aims to ensure that the largest student population earns the necessary skills, and it has developed a two-tier system involving facilitators who will enable the efficient expansion of the project’s educational outreach and support the students in learning the needed material efficiently. With a focus on real-world scenarios and innovative teaching activities integrating telemedicine devices and virtual professionals, SaNuRN is committed to enabling continuous learning for healthcare professionals in clinical practice. The SaNuRN team introduced new ways of evaluating healthcare professionals by shifting from a knowledge-based to a competencies-based evaluation, aligning with the Miller teaching pyramid and using the Objective Structured Clinical Examination and Script Concordance Test in digital health education. Drawing on the expertise of URN, CAU, and their public health and digital research laboratories and partners, the SaNuRN project represents a platform for continuous innovation, including telemedicine training and living labs with virtual and interactive professional activities. The SaNuRN project provides a comprehensive, personalized 30-hour training package for health and paramedical students, addressing all 70 FNRDH competencies. The program is enhanced using AI and NLP to create virtual patients and professionals for digital healthcare simulation. SaNuRN teaching materials are open-access. The project collaborates with academic institutions worldwide to develop educational material in digital health in English and multilingual formats. SaNuRN offers a practical and persuasive training approach to meet the current digital health education requirements.
BibTeX:
@article{Grosjean2024a,
  author = {Grosjean, Julien and Dufour, Frank and Benis, Arriel and Januel, Jean-Marie and Staccini, Pascal and Darmoni, Stéfan Jacques},
  title = {Digital {Health} {Education} for the {Future}: {The} {SaNuRN} ({Santé} {Numérique} {Rouen}-{Nice}) {Consortium}'s {Journey}},
  month = {April},
  journal = {JMIR medical education},
  year = {2024},
  volume = {10},
  pages = {e53997},
  doi = {10.2196/53997}
}

Abstract: OBJECTIVES: To analyse in routine practice the efficacy of targeted therapies on joint involvement of patients with rheumatoid arthritis/systemic sclerosis (RA/SSc) overlap syndrome.
METHODS: This was a retrospective analysis of medical records of two academic centres over a 10-year period. Joint response to targeted therapies was measured according to EULAR criteria based on Disease Activity Score (DAS)-28. In addition, changes in CRP level and glucocorticoid consumption were recorded.
RESULTS: Nineteen patients were included. Methotrexate (n=11) and hydroxychloroquine (n=4) were the most used first-line treatments. Targeted therapies were frequently used (n=14). Tocilizumab was the most selected therapy (n=8), then rituximab (n=5), abatacept and anti-tumour necrosis factor (n=4). Twenty-one treatment sequences were assessed, including 18 with EULAR response criteria. Responses were "good" or "moderate" in 100% (4/4) of patients treated with abatacept, 80% (4/5) with rituximab, 40% (2/5) with tocilizumab, and 25% (1/4) with anti-TNF. T and B lymphocyte-targeted therapies (abatacept, rituximab) resulted more frequently in a "good" or "moderate" response compared to cytokine inhibitors (tocilizumab, etanercept, infliximab) with a significant decrease in DAS-28 at 6 months (-1.75; p=0.016) and a trend to a lower consumption of glucocorticoids.
CCONCLUSIONS: In patients with RA/SSc overlap syndrome refractory to conventional synthetic-DMARDs, T and B lymphocyte-targeted therapies seem to be a promising therapeutic option to control joint activity.
BibTeX:
@article{Lebel2024,
  author = {Lebel, Nans and Marie, Isabelle and Grosjean, Julien and Brevet, Pauline and Leclercq, Mathilde and Dumont, Anaël and Levesque, Hervé and Benhamou, Ygal and Marcelli, Christian and Lequerre, Thierry and Vittecoq, Olivier},
  title = {Potential efficacy of {T} and {B} lymphocyte-targeted therapies on articular involvement of patients with rheumatoid arthritis and systemic sclerosis overlap syndrome. {Results} from a 2-centre series of 22 cases},
  month = {March},
  journal = {Clinical and Experimental Rheumatology},
  year = {2024},
  url = {https://www.clinexprheumatol.org/abstract.asp?a=19981}
}

Abstract: BACKGROUND: Prior studies showed that during the coronavirus disease 2019 (COVID-19) pandemic healthcare workers had a higher risk of developing post-traumatic stress disorder (PTSD) symptoms. However, studies conducted among doctors several years after the beginning of the COVID-19 pandemic are scarce.
AIMS: To evaluate the prevalence of PTSD among hospital doctors and to describe potential explanatory factors.
METHODS: The Protec-Cov study was an observational, cross-sectional, multicentre study, which used an anonymous online questionnaire to evaluate PTSD in doctors from six hospitals in France between December 2021 and March 2022. The presence of PTSD was assessed using the Post-traumatic Stress Disorder Checklist Scale (PCLS) questionnaire with a cut-off of 44.
RESULTS: Among the 307 doctors included, 18% presented a PCLS ≥44. The multivariate analysis showed that factors associated with a PCLS ≥44 were having a higher workload than before the COVID-19 pandemic (odds ratio [OR] = 4.75; 95% confidence interval [CI] 1.68-13.38), not feeling recognized within the professional environment (OR = 2.83; 95% CI 1.26-6.33), and feeling isolated because of the lockdown (OR = 4.2; 95% CI 1.97-8.95). Approximately 30% of hospital doctors (n = 91) felt a need for psychological support but only 31% of them (n = 28) received support.
CONCLUSIONS: Based on our findings, a high prevalence of PTSD was observed among hospital doctors 2 years after the beginning of the COVID-19 pandemic. This study supports an early diagnosis of PTSD in this category of healthcare workers and warrants further study.
BibTeX:
@article{Rollin2024,
  author = {Rollin, L. and Guerin, O. and Petit, A. and Bourdon, L. and Guillemette, S. and Gislard, A. and Clin, B. and Bachelet, L. and Rouget Mejjad, I. and Rouger, F. and Benichou, J. and Gehanno, J. F. and Commune, A.},
  title = {Post-traumatic stress disorder in hospital doctors after the {COVID}-19 pandemic},
  month = {February},
  journal = {Occupational Medicine (Oxford, England)},
  year = {2024},
  pages = {kqad125},
  doi = {10.1093/occmed/kqad125}
}

2023


Abstract: OBJECTIVE(S): Chronic kidney disease (CKD) is an insidious disease that requires early nephroprotective measures to delay progression to end-stage kidney disease. The objective of this study was to describe the management of patients with CKD in primary care, including clinical and biological monitoring and prescribed treatments. A retrospective, single-centre study was conducted on adult patients who were treated in the Maison de Neufchâtel (France) between 2012 and 2017 at least once a year. The inclusion criteria were 2 estimated glomerular filtration rate (eGFR) measurements textless60 mL/min more than 3 months apart. Two subgroups were constituted according to whether CKD was coded in the electronic medical records (EMRs).
RESULTS: A total of 291 (6.7 CI95% 5.9-7.4) patients with CKD were included. The mean eGFR was 51.0 ± 16.4 mL/min. Hypertension was the most frequent health problem reported (n = 93, 32. Nephrotective agents were prescribed in 194 (66.7 patients, non-steroidal anti-inflammatory drugs (NSAIDs) in 22 (8 patients, and proton-pump inhibitors (PPIs) in 147 (47 patients. CKD coding in EMRs was associated with dosage of natraemia (n = 34, 100 P textless 0.01), albuminuria (n = 20, 58 P textless 0.01), vitamin D (n = 14, 41 P textless 0.001), and phosphorus (n = 11, 32 P textless 0.001). Eighty-one patients (31.5 with low eGFR without an entered code for CKD were prescribed an albuminuria dosage. Clinical monitoring could not be analysed due to poor coding.
CONCLUSION: This pilot study reinforces the hypothesis that CKD is underscreened and undermanaged. More systematic coding of medical information in EMRs and further studies on medical centre databases should improve primary care practices.
BibTeX:
@article{Ariza2023,
  author = {Ariza, Matthieu and Martin, Steven and Dusenne, Mikaël and Darmon, David and Schuers, Matthieu},
  title = {Management of patients with chronic kidney disease: a {French} medical centre database analysis},
  month = {January},
  journal = {Family Practice},
  year = {2023},
  pages = {cmad004},
  doi = {10.1093/fampra/cmad004}
}

Abstract: OBJECTIVE: Planning reliable long-term planning actions to handle disruptive events requires a timely development of technological infrastructures, as well as the set-up of focused strategies for emergency management. The paper aims to highlight the needs for standardization, integration, and interoperability between Accident & Emergency Informatics (A&EI) and One Digital Health (ODH), as fields capable of dealing with peculiar dynamics for a technology-boosted management of emergencies under an overarching One Health panorama.
METHODS: An integrative analysis of the literature was conducted to draw attention to specific foci on the correlation between ODH and A&EI, in particular: (i) the management of disruptive events from private smart spaces to diseases spreading, and (ii) the concepts of (health-related) quality of life and well-being.
RESULTS: A digitally-focused management of emergency events that tackles the inextricable interconnectedness between humans, animals, and surrounding environment, demands standardization, integration, and systems interoperability. A consistent and finalized process of adoption and implementation of methods and tools from the International Standard Accident Number (ISAN), via findability, accessibility, interoperability, and reusability (FAIR) data principles, to Medical Informatics and Digital Health Multilingual Ontology (MIMO) - capable of looking at different approaches to encourage the integration between the ODH framework and the A&EI vision, provides a first answer to these needs.
CONCLUSIONS: ODH and A&EI look at different scales but with similar goals for converging health and environmental-related data management standards to enable multi-sources, interdisciplinary, and real-time data integration and interoperability. This allows holistic digital health both in routine and emergency events.
BibTeX:
@article{Benis2023,
  author = {Benis, Arriel and Haghi, Mostafa and Tamburis, Oscar and Darmoni, Stéfan J. and Grosjean, Julien and Deserno, Thomas M.},
  title = {Digital {Emergency} {Management} for a {Complex} {One} {Health} {Landscape}: the {Need} for {Standardization}, {Integration}, and {Interoperability}},
  month = {August},
  journal = {Yearbook of Medical Informatics},
  year = {2023},
  volume = {32},
  number = {1},
  pages = {27--35},
  doi = {10.1055/s-0043-1768742}
}

Abstract: AIMS: To describe the key elements of the interprofessional decision-making process in health, based on published scientific studies. To describe the authors, reviews and subject matter of those publications.
DESIGN: Scoping review of the literature.
DATA SOURCES: MEDLINE, APA Psycinfo OpenGrey, Lissa and Cochrane databases were searched in December 2019 and January 2023.
REVIEW METHODS: References were considered eligible if they (i) were written in French or English, (ii) concerned health, (iii) studied a clinical decision-making process, (iv) were performed in an interprofessional context. 'PRISMA-scoping review' guidelines were respected. The eligible studies were analysed and classified by an inductive approach RESULTS: We identified 1429 sources of information, 145 of which were retained for the analysis. Based on these studies, we identified five key elements of interprofessional decision-making in health. The process was found to be influenced by group dynamics, the available information and consideration of the unique characteristics of the patient. An organizational framework and specific training favoured improvements in the process.
CONCLUSION: Decision-making can be based on a willingness of the healthcare organization to promote models based on more shared leadership and to work on professional roles and values. It also requires healthcare professionals trained in the entire continuum of collaborative practices, to meet the unique needs of each patient. Finally, it appears essential to favour the sharing of multiple sources of accessible and structured information. Tools for knowledge formalization should help to optimize interprofessional decision-making in health.
IMPACT: The quality of a team decision-making is critical to the quality of care. Interprofessional decision-making can be structured and improved through different levels of action. These improvements could benefit to patients and healthcare professionals in every settings of care involving care collaboration.
IMPACT STATEMENT: Interprofessional decision-making in health is an essential lever of quality of care, especially for the most complex patients which are a contemporary challenge. This scoping review article offers a synthesis of a large corpus of data published to date about the interprofessional clinical decision-making process in healthcare. It has the potential to provide a global vision, practical data and a list of references to facilitate the work of healthcare teams, organizations and teachers ready to initiate a change.
BibTeX:
@article{Bouchez2023,
  author = {Bouchez, Tiphanie and Cagnon, Clémence and Hamouche, Gouraya and Majdoub, Marouan and Charlet, Jean and Schuers, Matthieu},
  title = {Interprofessional clinical decision-making process in health: {A} scoping review},
  month = {September},
  journal = {Journal of Advanced Nursing},
  year = {2023},
  doi = {10.1111/jan.15865}
}

Abstract: PURPOSE: This study aims to report on the effectiveness of various search strategies and keywords to find studies on work-related psychosocial risk factors (PRF) in the PubMed bibliographic database.
METHODS: We first selected by hand-searching 191articles published on PRF and indexed in PubMed. We extracted 30 relevant MeSH terms and 38 additional textwords. We then searched PubMed combining these 68 keywords and 27 general keywords on work-related factors. Among the 2953 articles published in January 2020, we identified 446 articles concerning exposure to PRF, which were gathered in a Gold Standard database. We then computed the Recall, Precision, and Number Needed to Read of each keyword or combination of keywords.
RESULTS: Overall, 189 search-words alone or in combination were tested. The highest Recall with a single MeSH term or textword was 43% and 35 respectively. Subsequently, we developed two different search strings, one optimizing Recall while keeping Precision acceptable (Recall 98.2 Precision 5.9 NNR 16.9) and one optimizing Precision while keeping Recall acceptable (Recall 73.1 Precision 25.5 NNR 9.7).
CONCLUSIONS: No single MeSH term is available to identify relevant studies on PRF in PubMed. Locating these types of studies requires the use of various MeSH and non-MeSH terms in combination to obtain a satisfactory Recall. Nevertheless, enhancing the Recall of search strategies may lead to lower Precision, and higher NNR, although with a non-linear trend. This factor must be taken into consideration when searching PubMed.
BibTeX:
@article{Gehanno2023a,
  author = {Gehanno, Jean-Francois and Thaon, Isabelle and Pelissier, Carole and Rollin, Laetitia},
  title = {Precision and {Recall} of {Search} {Strategies} for {Identifying} {Studies} on {Work}-{Related} {Psychosocial} {Risk} {Factors} in {PubMed}},
  month = {December},
  journal = {Journal of Occupational Rehabilitation},
  year = {2023},
  volume = {33},
  number = {4},
  pages = {776--784},
  doi = {10.1007/s10926-023-10110-w}
}

Abstract: BACKGROUND: Drug-related problems (DRPs) can lead to serious health issues and have significant economic impacts on healthcare systems. One solution to address this issue is the use of computerized physician order entry systems (CPOE), which can help prevent DRPs by reducing the risk of medication errors.
OBJECTIVE: The purpose of this study is to provide an analysis on scientific production of the past 20 years in order to describe trends in academic publishing on CPOE and to identify the major topics as well as the predominant actors (journals, countries) involved in this field.
METHODS: A PubMed search was carried out to extract articles related to computerized provider order entry during the period January 1st 2003- December 31st 2022 using a specific query. Data were downloaded from PubMed in Extensible Markup Language (XML) and were processed through a dedicated parser.
RESULTS: A total of 2,946 articles were retrieved among 623 journals. One third of these articles were published in eight journals. Publications grew strongly from 2002 to 2006, with a dip in 2008 followed by an increase again in 2009. After 2009, there follows a decreasing until 2022.The most producing countries are the USA with 51.39% of the publication over the period by France (3.80, and Canada (3.77. About disciplines, the top 3 is: "medical informatics" (21.62% of articles), "pharmacy" (19.04, and "pediatrics" (6.56.
DISCUSSION: This study provides an overview of publication trends related to CPOE, which exhibited a significant increase in the first decade of the 21st century followed by a decline after 2009. Possible reasons for this decline include the emergence of digital health tools beyond CPOE, as well as healthcare professionals experiencing alert fatigue of the current system.
CONCLUSION: Future research should focus on analyzing publication trends in the field of medical informatics and decision-making tools to identify other areas of interest that may have surpassed the development of CPOE.
BibTeX:
@article{Gosselin2023,
  author = {Gosselin, Laura and Leguillon, Romain and Rollin, Laetitia and Lejeune, Emeline and Darmoni, Stéfan J. and Grosjean, Julien},
  title = {Trends in computerized provider order entry: 20-year bibliometric overview},
  journal = {Frontiers in Digital Health},
  year = {2023},
  volume = {5},
  pages = {1217694},
  doi = {10.3389/fdgth.2023.1217694}
}

Abstract: BACKGROUND: French guidelines for the prevention of vascular access infections in a haemodialysis setting were released in 2005. Compliance with these guidelines is currently unknown. Our aim was to assess compliance with guidelines for vascular access infection prevention in French haemodialysis units, and to describe the difficulties reported.
METHODS: A cross-sectional survey was conducted between March and December 2019 in 200 haemodialysis units randomly selected in France. Data were collected via questionnaire, completed by telephone interview with an infection control practitioner. A practice was deemed compliant when textgreater 85% of units declared always complying with guidelines.
RESULTS: A total of 103 units (51.5 agreed to participate. Most practices complied with guidelines, however some of them (working in pairs when connecting central venous catheter (CVC) lines, performing hand hygiene before disconnecting lines, rinsing antiseptic soap before painting CVC exit site or arteriovenous fistula (AVF) puncture site, allowing antiseptic paint to dry, handling CVC branches with antiseptic impregnated gauze, performing hand hygiene after AVF compression with gloves, wearing protective eyewear when connecting/disconnecting CVC or when puncturing AVF, wearing a gown when puncturing AVF) did not reach the 85% compliance threshold. Most frequently reported difficulties were understaffing, difficulties with skin preparation because of exit site skin damage, and lack of buttonhole technical expertise.
CONCLUSIONS: Despite good overall compliance, this survey highlights some shortcomings in complying with infection prevention guidelines, which could be associated with either higher vascular access infection risk or with increased blood-borne virus transmission.
BibTeX:
@article{Habihirwe2023,
  author = {Habihirwe, Philbert and Marini, Hélène and Wurtz, Blandine and Vermeulin, Thomas and Lottin, Marion and Gehanno, Jean François and Boulet, Ludivine and Vergnes, Hervé and Edet, Stéphane and Guet, Laurence and Le Roy, Frank and Merle, Véronique},
  title = {Compliance with good practice guidelines for the prevention of vascular access infections: {The} multicentre {PHYDEL} survey in {French} haemodialysis units},
  month = {September},
  journal = {The Journal of Hospital Infection},
  year = {2023},
  pages = {S0195--6701(23)00294--3},
  doi = {10.1016/j.jhin.2023.09.007}
}

Abstract: PURPOSE: Studies in the United States, Canada, Belgium, and Switzerland showed that the majority of health problems are managed within primary health care; however, the ecology of French medical care has not yet been described.
METHODS: Nationwide, population-based, cross sectional study. In 2018, we included data from 576,125 beneficiaries from the General Sample of Beneficiaries database. We analysed the reimbursement of consultations with (i) a general practitioner (GP), (ii) an outpatient doctor other than a GP, (iii) a doctor from a university or non-university hospital; and the reimbursement of (iv) hospitalization in a private establishment, (v) general hospital, and (vi) university hospital. For each criterion, we calculated the average monthly number of reimbursements reported on 1,000 beneficiaries. For categorical variables, we used the χ2 test, and to compare means we used the z test. All tests were 2-tailed with a P-value textless 5% considered significant.
RESULTS: Each month, on average, 454 (out of 1,000) beneficiaries received at least 1 reimbursement, 235 consulted a GP, 74 consulted other outpatient doctors in ambulatory care and 24 in a hospital, 13 were hospitalized in a public non-university hospital and 10 in the private sector, and 5 were admitted to a university hospital. Independently of age, people consulted GPs twice as much as other specialists. The 13-25-year-old group consulted the least. Women consulted more than men. Individuals covered by complementary universal health insurance had more care.
CONCLUSIONS: Our study on reimbursement data confirmed that, like in other countries, in France the majority of health problems are managed within primary health care.
BibTeX:
@article{Laporte2023,
  author = {Laporte, Catherine and Fortin, Frédéric and Dupouy, Julie and Darmon, David and Pereira, Bruno and Authier, Nicolas and Delorme, Jessica and Chenaf, Chouki and Maisonneuve, Hubert and Schuers, Matthieu},
  title = {The {French} ecology of medical care. {A} nationwide population-based cross sectional study},
  month = {November},
  journal = {Family Practice},
  year = {2023},
  pages = {cmad098},
  doi = {10.1093/fampra/cmad098}
}

BibTeX:
@article{Leguillon2023,
  author = {Leguillon, Romain and Gosselin, Laura and Carnoy, Christophe and Pressat-Laffouilhere, Thibaut and Letord, Catherine and Dahamna, Badisse and Darmoni, Stéfan J. and Grosjean, Julien},
  title = {Integrating a new knowledge organisation system for monoclonal antibodies for therapeutic use authorised in {Europe} into {HeTOP} {Terminology}-{Ontology} {Server}},
  month = {March},
  journal = {Journal of Biomedical Informatics},
  year = {2023},
  pages = {104325},
  url = {https://linkinghub.elsevier.com/retrieve/pii/S1532046423000461},
  doi = {10.1016/j.jbi.2023.104325}
}

Abstract: INTRODUCTION: Clinical pharmacist (CP) intervention improves drug prescription by identifying potentially inappropriate prescriptions (PIPs). Geriatric perioperative care units (UPOGs) provide enhanced care for patients with hip fracture, including drug prescription. However, it is not known whether adding a CP intervention in a UPOG decreases the number of PIPs. This study aimed to evaluate the effect of a CP intervention, combining an implicit and an explicit method, on the number of PIPs in a UPOG.
METHODS: This single centre before-after-control-impact study recruited patients aged over 75 years admitted to a UPOG for a hip fracture. The "control group" ("before period") received usual care including two medication reconciliations, one at admission and one at discharge. The "intervention group" ("after period") received usual care and a CP intervention including two medication reconciliations, a medication review with two tools, STOPP/START and Medication Appropriateness Index, and a meeting between a CP and geriatricians. PIPs were assessed in both groups by STOPP/START and Medication Appropriateness Index and compared from hospital admission to discharge.
RESULTS: A total of 209 patients were included, 150 in the control group and 59 in the intervention group (mean age: 87.2 ± 5.9 years). The number of PIPs decreased in both groups from hospital admission to discharge (p textless 0.001). The number of PIPs, potentially inappropriate medications, and potential prescribing omissions decreased more in the intervention group than in the control group (adjusted intervention effect: -2.46 (95% CI: -2.63; -2.24); -1.13 (95% CI: -1.27; -0.98); and -1.35 (95% CI: -1.52; -1.18), respectively, p textless 0.001 for all).
DISCUSSION/CONCLUSION: A CP intervention with an explicit and implicit method improved prescriptions in a UPOG. Further randomized studies are necessary to evaluate the effect of a CP intervention on adverse drug events, health costs, and mortality.
BibTeX:
@article{Leguillon2023a,
  author = {Léguillon, Romain and Varin, Rémi and Pressat-Laffouilhère, Thibaut and Chenailler, Catherine and Chassagne, Philippe and Roca, Frédéric},
  title = {Clinical {Pharmacist} {Intervention} {Reduces} {Potentially} {Inappropriate} {Prescriptions} in a {Geriatric} {Perioperative} {Care} {Unit} {Dedicated} to {Hip} {Fracture}},
  journal = {Gerontology},
  year = {2023},
  volume = {69},
  number = {4},
  pages = {386--395},
  doi = {10.1159/000526595}
}

Abstract: BACKGROUND: Omalizumab (OMA) dramatically improves disease control and quality of life in patients with chronic urticaria (CU).
OBJECTIVE: We aimed to evaluate the discontinuation patterns of OMA and their determinants in a cohort of French patients with CU.
METHODS: We conducted a retrospective multicenter study in nine French tertiary referral hospitals. All patients diagnosed with either spontaneous (CSU) and/or inducible (CIndU) CU who received at least one injection of OMA between 2009 and 2021 were included. We analyzed OMA drug survival and investigated possible determinants using Kaplan-Meier curves and log-rank tests.
RESULTS: A total of 878 patients were included in this study; 48.8% had CSU, 10.1% CIndU, and 41.1% a combination of both. OMA was discontinued in 408 patients but the drug was later reintroduced in 50% of them. The main reason for discontinuing treatment was the achievement of a well-controlled disease in 50% of patients. Half of the patients were still being treated with OMA 2.4 years after the initiation of treatment. Drug survival was shorter in patients with CIndU and in those with an autoimmune background. In atopic patients, OMA was discontinued earlier in patients achieving a well-controlled disease. A longer OMA drug survival was observed in patients with a longer disease duration at initiation.
CONCLUSION: In French patients with CU, the drug survival of OMA appears to be longer than that observed in previous studies conducted elsewhere, highlighting discrepancies in prescription and reimbursement possibilities. Further studies are warranted to develop customized OMA treatment schemes based on individual patterns.
BibTeX:
@article{Litovsky2023,
  author = {Litovsky, Julie and Hacard, Florence and Tetart, Florence and Boccon-Gibod, Isabelle and Soria, Angele and Staumont-Salle, Delphine and Doutre, Marie-Sylvie and Amsler, Emmanuelle and Mansard, Catherine and Dezoteux, Frederic and Darrigade, Anne-Sophie and Milpied, Brigitte and Bernier, Claire and Perrot, Jean-Luc and Raison-Peyron, Nadia and Paryl, Marie and Droitcourt, Catherine and Demoly, Pascal and Grosjean, Julien and Mura, Thibault and Du-Thanh, Aurelie and study group of French Dermatology Society, Urticaria},
  title = {Omalizumab drug survival in chronic urticaria: a retrospective multicentric {French} study},
  month = {August},
  journal = {The Journal of Allergy and Clinical Immunology. In Practice},
  year = {2023},
  pages = {S2213--2198(23)00956--X},
  doi = {10.1016/j.jaip.2023.08.033}
}

Abstract: INTRODUCTION: Acute respiratory infections (ARIs) are the most common viral infections encountered in primary care settings. The identification of causal viruses is still not available in routine practice. Although new strategies of prevention are being identified, knowledge of the relationships between respiratory viruses remains limited.
MATERIALS AND METHODS: ECOVIR was a multicentric prospective study in primary care, which took place during two pre-pandemic seasons (2018-2019 and 2019-2020). Patients presenting to their General practitioner (GP) with ARIs were included, without selecting for age or clinical conditions. Viruses were detected on nasal swab samples using a multiplex Polymerase Chain Reaction test focused on 17 viruses [Respiratory Syncytial Virus-A (RSV-A), RSV-B, Rhinovirus/Enterovirus (HRV), human Metapneumovirus (hMPV), Adenovirus (ADV), Coronaviruses (CoV) HKU1, NL63, 229E, OC43, Influenza virus (H1 and H3 subtypes), Influenza virus B, Para-Influenza viruses (PIVs) 1-4, and Bocavirus (BoV)].
RESULTS: Among the 668 analyzed samples, 66% were positive for at least one virus, of which 7.9% were viral codetections. The viral detection was negatively associated with the age of patients. BoV, ADV, and HRV occurred more significantly in younger patients than the other viruses (p textless 0.05). Codetections were significantly associated with RSV, HRV, BoV, hMPV, and ADV and not associated with influenza viruses, CoV, and PIVs. HRV and influenza viruses were negatively associated with all the viruses. Conversely, a positive association was found between ADV and BoV and between PIVs and BoV.
CONCLUSION: Our study provides additional information on the relationships between respiratory viruses, which remains limited in primary care.
BibTeX:
@article{Petat2023,
  author = {Petat, Hortense and Schuers, Matthieu and Marguet, Christophe and Humbert, Xavier and Le Bas, François and Rabiaza, Andry and Corbet, Sandrine and Leterrier, Bryce and Vabret, Astrid and Ar Gouilh, Meriadeg},
  title = {Positive and negative viral associations in patients with acute respiratory tract infections in primary care: the {ECOVIR} study},
  journal = {Frontiers in Public Health},
  year = {2023},
  volume = {11},
  pages = {1269805},
  doi = {10.3389/fpubh.2023.1269805}
}

Abstract: BACKGROUND: The management of adult male urinary tract infections (mUTIs) in primary care lacks international consensus. The main objective of this study was to describe the different guidelines for the diagnosis and management of mUTIs in primary care, to assess their methodological quality, and to describe their evidence-based strength of recommendation (SoR).
METHODS: An international systematic literature review of the electronic databases Medline (PubMed) and EMBASE, and gray-literature guideline-focused databases was performed in 2021. The Appraisal of Guidelines for Research and Evaluation (AGREE II) assessment tool was used by 2 independent reviewers to appraise each guideline.
RESULTS: From 1,678 records identified, 1,558 were screened, 134 assessed for eligibility, and 29 updated guidelines met the inclusion criteria (13 from Medline, 0 from EMBASE, and 16 from gray literature). Quality assessment revealed 14 (48 guidelines with high-quality methodology. A grading system methodology was used in 18 (62 guidelines. Different classifications of mUTIs are described, underlining a lack of international consensus: an anatomic classification (cystitis, prostatitis, pyelonephritis) and a symptomatic classification (approach based on the intensity and tolerance of symptoms). The duration of antibiotic treatment for febrile mUTIs has been gradually reduced over the last 20 years from 28 days to 10-14 days of fluoroquinolones (FQ), which has become the international gold standard. Guidelines from Scandinavian countries propose short courses (3-5 days) of FQ-sparing treatments: pivmecillinam, nitrofurantoin, or trimethoprim. Guidelines from French-speaking countries use a watchful waiting approach and suggest treating mUTIs with FQ, regardless of fever.
CONCLUSIONS: This lack of scientific evidence leads to consensus and disagreement: 14 days of FQ for febrile mUTIs is accepted despite a high risk of antimicrobial resistance, but FQ-sparing treatment and/or short treatment for afebrile mUTIs is not. The definition of afebrile UTIs/cystitis is debated and influences the type and duration of antibiotic treatment recommended.
BibTeX:
@article{Soudais2022,
  author = {Soudais, Benjamin and Ribeaucoup, Florian and Schuers, Matthieu},
  title = {Guidelines for the management of male urinary tract infections in primary care: a lack of international consensus-a systematic review of the literature},
  month = {February},
  journal = {Family Practice},
  year = {2023},
  volume = {40},
  number = {1},
  pages = {152-175},
  doi = {10.1093/fampra/cmac068}
}

Abstract: Résumé
Introduction
La carrière professionnelle peut être modifiée par des problèmes de santé. L'altération professionnelle, notifiée par le médecin du travail, peut être suivie d'une recherche de reclassement ou d'une désinsertion professionnelle.
Objectifs
Décrire le profil des travailleurs déclarés inaptes à leur poste de travail et décrire le profil de ceux qui n'ont pas de capacité de travail restante (CTR).
Méthodes
Population de travailleurs suivie par un service de santé au travail interentreprises de 20 médecins du travail. Les caractéristiques des travailleurs déclarés inaptes à leur poste de travail ont été extraites des dossiers médicaux (âge, sexe, secteur d'activité (Naf), catégorie socioprofessionnelle (PCS), pathologie entraînant une déficience professionnelle (CIM10), statut d'obligation d'emploi de travailleurs handicapés (BOETH). Les facteurs associés à l'inaptitude au travail dû à l'absence de capacité de travail restante (CTR) ont été identifiés par des modèles de régression logistique.
Résultats
En 2019, 82 678 travailleurs ont été suivis par le SPSTI et 554 travailleurs ont été déclarés inaptes à leur poste de travail par le médecin du travail (0,67 % des travailleurs), dont 162 n'avaient pas de CTR. Les taux d'inaptitude étaient les plus importants chez les femmes et les travailleurs de plus de 55 ans. Les pathologies psychiques (29 et rhumatologiques (50 étaient plus souvent à l'origine de l'inaptitude professionnelle. Le statut BOETH a été identifié pour 63 % des travailleurs. Les facteurs significativement associés à l'absence de CTR étaient l'âge textgreater 45 ans et la pathologie psychique, alors que le sexe, le secteur d'activité et la PCS ne l'étaient pas.
Discussion
Aucune administration publique ne recense l'ensemble des inaptitudes professionnelles en France. Les études antérieures ont décrit le profil des travailleurs inaptes à leur poste de travail mais aucune n'a décrit le profil de ceux qui n'ont pas de CTR. Ces travailleurs sont pourtant exposés à un risque élevé de précarité.
Conclusions
Les pathologies psychiques sont les pathologies qui génèrent le plus d'inaptitudes professionnelles sans CTR. La prévention de ces pathologies est essentielle. Les pathologies rhumatologiques sont la première cause d'inaptitude au poste de travail mais la proportion de travailleurs sans CTR est moins importante. Celles-ci peuvent être en relation avec les efforts déployés pour le retour au travail de ces patients.
BibTeX:
@article{Courtois2023,
  author = {Courtois, R. and Couvreur, M. and Gehanno, J. F. and Rollin, L.},
  title = {Analyse du profil des salariés déclarés inaptes au poste de travail : quelle place pour les facteurs sociétaux ou extra-professionnels et quelles conséquences sur l'emploi ?},
  month = {August},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2023},
  volume = {71},
  number = {4},
  pages = {102089},
  url = {https://www.sciencedirect.com/science/article/pii/S0398762023006740},
  doi = {10.1016/j.respe.2023.102089}
}

Abstract: L’accès aux revues médicales scientifiques est indispensable pour les médecins ou les paramédicaux qui souhaitent maintenir à jour leurs connaissances, se documenter pour la prise en charge d’un patient ou s’engager dans des travaux de recherche. Au-delà des outils anglo-saxons (Pub-Med, Google Scholar) qui impliquent de réaliser la recherche documentaire en anglais et qui listent principalement des ressources en anglais, il existe des outils qui permettent une recherche en français et couvrent des ressources en français de façon beaucoup plus complète que les outils anglosaxons. Nous présentons tout d’abord le portail en français CISMeF (Catalogue et Index des sites médicaux de langue française) ouvrant l’accès à une base de données centrée sur les ressources Internet médicales en français (doc’CISMEF) et sur la base LiSSa (Littérature scientifique médicale francophone en santé), tous deux utilisant un moteur de recherche en français : HeTOP (Health Terminology/Ontology Portal). D’autres bases de données et moteurs de recherche en français sont ensuite présentés, soit généralistes (Summon, Wikipédia Encyclopédie médicale), soit spécialisés (Recomedical, VIDAL, Orphanet, Agents tératogènes). Ils sont pour la plupart interfacés et reliés à PubMed. Leur utilité au quotidien nous paraît indiscutable que ce soit pour la recherche documentaire « à froid », mais aussi directement pour la prise en charge des patients au cabinet ou à l’hôpital.
BibTeX:
@article{Joly2023,
  author = {Joly, L.-M. and Leroy, J.-P. and Roussel, M. and Darmoni, S.},
  title = {Bases de données médicales scientifiques et moteurs de recherche en français},
  journal = {Annales françaises de médecine d’urgence},
  year = {2023},
  note = {Publisher: Lavoisier},
  url = {https://afmu.revuesonline.com/articles/lvafmu/abs/first/lvafmu_2023_sprurge001293/lvafmu_2023_sprurge001293.html},
  doi = {10.3166/afmu-2022-0459}
}

Abstract: Les recommandations récentes de l’ESC introduisent la possibilité de réaliser des cycles rapides de troponine dans le cadre d’une suspicion d’un SCA ST-. Ces recommandations offrent la possibilité d’utilisation de systèmes délocalisés sous réserve qu’ils aient une grande sensibilité analytique. L’objectif de notre étude est d’évaluer en vie réelle la faisabilité et les performances d’un dosage de troponine I-hs (TnI-hs, Atellica® VTLi, Siemens) délocalisé comparé aux valeurs obtenues de troponine T-hs (TnT-hs, e602®, Roche) pour des patients consultant dans un service d’urgences. Les CV de répétabilité et reproductibilité de la TnI-hs sont inférieurs à 10 %. La comparaison des deux troponines est modérée (r = 0,7). Les 117 patients inclus dans l’étude ont un âge médian de 65 ans, 30 % sont insuffisants rénaux et 36 % consultent pour douleur thoracique. Dans notre étude, la TnT-hs est plus souvent supérieure au 99e percentile que la TnI-hs et ceux même pour un 99e percentile de TnT-hs adapté à l’âge. La concordance des résultats est modérée (Kappa de Cohen : 0,54), l’âge restant la valeur explicative la plus importante des discordances. Seule la TnT-hs présente une valeur prédictive concernant l’hospitalisation. Nous n’avons pas observé de discordances d’interprétation pour les patients ayant eu une cinétique de troponine. Cette étude conforte la faisabilité d’utiliser un système de biologie délocalisée aux urgences sous réserve qu’il réalise une troponine hypersensible. Cependant, des données sont manquantes pour pouvoir l’utiliser dans le cadre d’algorithme rapide. Enfin, cette implémentation nécessite une collaboration clinico-biologique étroite tant sur l’organisation que sur l’interprétation des valeurs afin d’améliorer le service médical rendu au patient.
BibTeX:
@article{Mottin2023,
  author = {Mottin, Léo and Kassimy, Iliasse Idrissi and Girot, Hélène and Leguillon, Romain and Joly, Luc Marie and Brunel, Valery},
  title = {Évaluation en vie réelle de la mesure de troponine {I} hypersensible sur un système de biologie délocalisée pour un service d’urgences},
  month = {May},
  journal = {Annales De Biologie Clinique},
  year = {2023},
  volume = {81},
  number = {2},
  pages = {145--155},
  url = {https://www.jle.com/fr/revues/abc/e-docs/evaluation_en_vie_reelle_de_la_mesure_de_troponine_i_hypersensible_sur_un_systeme_de_biologie_delocalisee_pour_un_service_durgences_330643/article.phtml},
  doi = {10.1684/abc.2023.1804}
}

Abstract: Industrie en plein essor, le secteur de la logistique est soumis à une forte sinistralité en termes d’accidents du travail et de maladies professionnelles. Notre objectif était de décrire les conditions de travail et l’état de santé des travailleurs du secteur de la logistique en les comparant avec les salariés des autres secteurs professionnels.
Méthodes
Une étude épidémiologique descriptive a été réalisée à partir des données des enquêtes Sumer 2010 et 2017 et de l’observatoire Evrest (2008–2012 et 2013–2017).
Résultats
Les métiers de la logistique comportent une charge physique omniprésente incluant plus de manutention manuelle de charge et de contraintes articulaires que dans les autres secteurs professionnels. Additionnés à un travail en ambiance froide et soumis aux vibrations des engins de manutention, une prévalence importante d’atteintes du rachis et des membres supérieurs est mise en évidence chez les salariés de la logistique. Le bruit des entrepôts et l’utilisation de la commande vocale sont source de fatigue auditive. D’autre part, ils présentent une faible latitude décisionnelle découlant d’une organisation de travail rigide avec une préparation des commandes à flux tendu et des délais stricts à respecter pour répondre aux exigences croissantes des clients. Pourtant, en partie grâce à un fort soutien social, leur santé mentale reste préservée. Il n’est pas retrouvé plus d’arrêts ou d’accidents du travail que dans les autres secteurs mais notre méthode ne permettait pas d’inclure les travailleurs intérimaires qui représentent jusqu’à 30 % des effectifs en logistique.
Conclusion
Afin d’approfondir nos connaissances sur le secteur de la logistique, il conviendrait de développer un suivi longitudinal des salariés, ciblé par métier et intégrant les salariés intérimaires, pour préciser les risques psychosociaux et leur conséquence sur la survenue de troubles musculosquelettiques et sur la sinistralité du secteur.
BibTeX:
@article{Naili2023,
  author = {Naïli, M. and Fort, E. and Rollin, L. and Leroyer, A. and Gavoille, A. and Desbas, A. and Charbotel, B.},
  title = {Évaluation des conditions de travail et de l’état de santé des travailleurs en entrepôts et plateformes logistiques},
  month = {June},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2023},
  volume = {84},
  number = {3},
  pages = {101669},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878522003320},
  doi = {10.1016/j.admp.2022.10.001}
}

Abstract: Objectifs
Évaluer rétrospectivement le taux de salariés, confinés (en télétravail) et non confinés, infectés par le SARS-CoV-2 après le 1er confinement (avril à mai 2020).

Méthode
Un dépistage sérologique des anticorps anti-SARS-CoV-2, IgG et IgM, et un questionnaire sur leurs symptômes a été proposé aux 2090 salariés d’une même entreprise.

Résultats
La sérologie était positive pour 5,6 % des 786 salariés inclus entre fin avril et juillet 2020 : 4,05 % chez les non confinés, et 6,72  chez les confinés (p = NS). Parmi les positifs, 86,4 % avaient présenté des symptômes, sans différence significative entre confinés et non confinés. Enfin, 1,7 % des asymptomatiques étaient positifs. Les symptômes n’étaient pas significativement différents entre les 2 groupes sauf pour l’anosmie-agueusie significativement plus fréquente dans le groupe des confinés. Les symptômes significativement associés à une sérologie positive étaient l’anosmie-agueusie, la fièvre-sensation de fièvre-frissons, les courbatures, la fatigue malaise, un syndrome grippal et des symptômes respiratoires. Ce faible taux de contamination peut être le résultat des mesures de prévention renforcées mises en place pour les salariés dès fin janvier 2020 par le médecin du travail pour limiter le risque de contamination au sein des locaux.

Conclusion
La prévalence du SARS-CoV-2 dans l’entreprise de fin avril à juillet 2020 était inférieure de moitié au taux rapporté dans la population d’Ile de France à la même période sans différence entre les salariés ayant poursuivi leur activité en présentiel par rapport aux confinés.
BibTeX:
@article{Sauvage2023,
  author = {Sauvage, E. and Gehanno, J. F. and Thomas, N. and Rollin, L.},
  title = {Prévalence du {SARS}-{CoV}-2, étude sérologique en {France} chez des salariés non confinés et confinés},
  month = {August},
  journal = {Archives Des Maladies Professionnelles et De L'Environnement},
  year = {2023},
  volume = {84},
  number = {4},
  pages = {101798},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892330/},
  doi = {10.1016/j.admp.2023.101798}
}

Abstract: The national teleconsultation platform Qare offers a promising tool to collect data in primary care by sharing the same EHR among teleconsultants. Conclusions for every teleconsultation are thus collected by a text using an ICD10 code or not. Nevertheless, the use of the ICD10 classification by primary care doctors is scarce. We developed an algorithm based on bags of words that associates an ICD10 code for each textual conclusion and evaluated it. It shows good performances (88 to 89% concordance) to assign ICD10 category. It could be used to enhance the volume of coded teleconsultations ready to be reused.
BibTeX:
@inproceedings{Melot2023,
  author = {Melot, Bénédicte and Drouet, Florian and Alvarez, Caroline and Grimshaw, Céline and Grosjean, Julien and Duclos, Catherine},
  title = {Automated {ICD10}-{Coding} of {Teleconsultations} {Conclusions} in {Primary} {Care}},
  booktitle = {Studies in {Health} {Technology} and {Informatics}},
  month = {October},
  publisher = {IOS Press},
  year = {2023},
  url = {https://ebooks.iospress.nl/doi/10.3233/SHTI230758},
  doi = {10.3233/SHTI230758}
}

BibTeX:
@article{Angelozzi2023,
  author = {Angelozzi, L. and Gillibert, A. and Grosjean, J. and Brevet, P. and Jouen, F. and Lequerré, T. and Vittecoq, O.},
  title = {Analyse comparative du profil clinique, de la prise en charge thérapeutique et du pronostic sous traitement des patients atteints d’une polyarthrite rhumatoïde immunopositive ou immunonégative après l’introduction d’une première thérapie ciblée},
  month = {December},
  journal = {Revue du rhumatisme},
  year = {2023},
  volume = {90},
  pages = {A91--A92},
  url = {https://www.lissa.fr/fr/rep/articles/EL_S1169833023005124},
  doi = {10.1016/j.rhum.2023.10.139}
}

Abstract: Introduction
Dans un contexte de crise des opioïdes mondiale qui touche préférentiellement les États-Unis, la France est le troisième pays européen en 2015 consommateur d’opioïdes faibles au premier rang desquels figure le tramadol [1]. L’objectif principal est de dresser un état des lieux des habitudes de prescription du tramadol chez les rhumatologues français. L’objectif secondaire est de vérifier si leurs habitudes de prescriptions sont en accord avec les recommandations HAS de mars 2022 sur le bon usage des opioïdes notamment sur son utilisation en dernière intention dans la prise en charge de certaines douleurs chroniques : lombalgie, lomboradiculalgie ou arthrose [2].
Matériels et méthodes
Pour répondre à l’objectif principal, nous avons adressé en juillet 2022 via la mailing-list de la SFR, un questionnaire de 46 questions recueillant les habitudes de prescription des rhumatologues français en collaboration avec le Cercle d’étude de la douleur en rhumatologie. En complément, les prescriptions du tramadol de la base de données du Système national des données de santé (SNDS) ont été extraites. Pour répondre à l’objectif secondaire, nous avons comparé les données déclarées des prescriptions avec les recommandations HAS 2022 sur le bon usage des opioïdes [2].
Résultats
Concernant les résultats du questionnaire : 296 rhumatologues ont rempli le questionnaire sur les 1760 sollicités. Ils prescrivent principalement du tramadol pour les radiculalgies et rachialgies aiguës alors que les radiculalgies et rachialgies chroniques arrivent en 4e et 5e positions des indications. 22,3 % prescrivent du tramadol en situation de douleur chronique en l’absence de diagnostic étiologique. L’association tramadol/paracétamol est la forme pharmaceutique la plus prescrite (68,1 % des répondants). 45,3 % utilisent une Échelle Visuelle Analogique ou Numérique dans un contexte de douleur chronique. 74,4 % fixent une durée de prescription au-delà de laquelle, sans bénéfice pour le patient, le traitement est interrompu et/ou une consultation spécialisée douleur est organisée. 31 % déclarent ne pas avoir de freins par rapport à la prescription de tramadol. 52 % ne connaissent pas les recommandations HAS 2022 [2]. Concernant les résultats du SNDS : entre 2016 et 2022, on note une diminution de : 40 % des prescriptions de tramadol par les rhumatologues (65 543 vs 40 905) et 47 % des prescriptions de tramadol associé au paracétamol (83 032 vs 43 311).
Conclusion
Dans le contexte de crise des opioïdes, la France fait figure de bon élève avec une mortalité par surdoses d’opioïdes parmi les plus faibles des pays membres de l’OCDE (d’après Obradovic et al.). Cela est cohérent avec la tendance actuelle à la diminution de la prescription de tramadol par les médecins généralistes et surtout par les rhumatologues. La prescription de tramadol par les rhumatologues français est raisonnée.
BibTeX:
@article{Bibaut2023,
  author = {Bibaut, L. and Lacroix, E. and Grosjean, J. and Bernard, A. and Jansseune, Q. and Lequerré, T. and Vittecoq, O. and Pouplin, S.},
  title = {État des lieux de la prescription du tramadol pour les douleurs en rhumatologie par les rhumatologues français},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2023},
  series = {36e {Congrès} {Français} de {Rhumatologie}},
  volume = {90},
  pages = {A13--A14},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833023003927},
  doi = {10.1016/j.rhum.2023.10.019}
}

Abstract: Introduction (contexte de la recherche)
L’œsophagite à éosinophiles (EoE) a une physiopathologie encore incomplètement comprise. Sa présence accrue chez les patients atopiques et également chez des patients sans antécédent atopique fait suggérer l’existence de phénotypes cliniques et physiopathologiques différents.
Objectif
Évaluer l’implication de l’allergie notamment alimentaire dans l’EoE en recherchant l’existence de plusieurs phénotypes d’EoE : allergique (A) et non allergique (nA) selon différents immunomarquages.
Méthodes
Étude rétrospective sur 20ans, monocentrique, non interventionnelle (Hors Loi Jardé), validée par l’EDSaN et par la CNIL (n° 2021/0363/OB). Étude des données démographiques, clinico-biologiques des patients atteints d’EoE. Des marquages immunohistochimiques (CD3, CD117/KIT, tryptase, IL5) ont été réalisés sur biopsies d’EoE et sur tissus de patients témoins (×10). Les patients étaient classés selon différents groupes : (A)/Atopique seul ; A/Induit à l’aliment et nA. Les tests de Mann-Whitney et de Fischer ont été utilisés selon le type de variable, seuil de significativité corrigé au nb de comparaison (p valuetextless0,002) et réalisation d’une analyse en composante principale.
Résultats
Démographie : 82 patients ont été inclus (26 A dont 8 induit à l’aliment et 18 atopique seul et 56 nA). Immunomarquages : le comptage des immunomarquages CD3, CD117/KIT, tryptase, IL5 était significativement plus important dans les groupes A que nA (respectivement : 57 (22,2) vs 42,3 (18,5), p : 0,003 ; 11,1 (9,7) vs 5,2 (4,9), ptextless0,001 ; 16,3 (9) vs 4,9 (2,6), ptextless0,001 ; 1,9 (2,5) vs 0,05 (0,3), ptextless0,001). De même, le comptage était significativement plus important au sein du sous-groupe Induit par l’aliment versus les nA. Enfin le sous-groupe Induit à l’aliment montrait également un marquage plus important que le sous-groupe atopique, en ce qui concerne les marqueurs CD117/KIT et IL5, respectivement (18,3 (12,9) vs 7,9 (6,1), p : 0,002 ; 2,8 (1,7) vs 1,4 (2,7), p : 0,031).
Conclusions
Nos résultats appuient une différence phénotypique dans l’EoE ouvrant la question sur des différences physiopathologiques entre les patients A / Induit par l’aliment par rapport aux autres patients (nA et A / Atopique seul).
BibTeX:
@article{Lagassy2023,
  author = {Lagassy, M. and Pressat Laffouilhere, T. and Grosjean, J. and Leblond, L. and Dordain, S. and Mahay, G. and Couderc, L. and Dumant-Forest, C. and Sabourin, J. C. and Martinet, J. and Coëffier, M.},
  title = {Résultats préliminaires de l’étude {Profil}-{Eo} : différents profils d’œsophagite à éosinophiles (allergique et non allergique) selon de multiples immunomarquages tissulaires},
  month = {April},
  journal = {Revue Française d'Allergologie},
  year = {2023},
  series = {18e {Congrès} {Francophone} d'{Allergologie}},
  volume = {63},
  number = {3},
  pages = {103385},
  url = {https://www.sciencedirect.com/science/article/pii/S1877032023001094},
  doi = {10.1016/j.reval.2023.103385}
}

Abstract: Introduction
Les cathéters intra veineux de longue durée (CIVLD) sont des dispositifs fréquents. Les bactériémies liées aux CIVLD sont une des principales complications. L'objectif principal de cette étude est de mesurer l'efficacité des verrous antibiotiques pour le traitement des bactériémies liées aux CIVLD. Les objectifs secondaires sont d'estimer la mortalité liée à l'infection de CIVLD, la mortalité toute cause et de trouver d'éventuels facteurs pronostics.
Matériels et méthodes
Il s'agit d'une étude rétrospective incluant l'ensemble des patients traités dans notre centre hospitalo-universitaire pour une bactériémie liée aux CIVLD entre 2014 et 2022. Les critères diagnostics ont été défini selon les dernières recommandations de la Société de Pathologie Infectieuse de Langue Française (SPILF). L'ensemble des patients ont été traité et suivi selon un protocole standardisé locale. La guérison était définie par la stérilité des hémocultures de contrôle associée à l'amendement des signes cliniques et à l'absence de rechute ou du retrait du cathéter à cause d'une infection à 1 mois de la fin du traitement. Les décès non liés au traitement étaient censurés.
Résultats
Un total de 60 épisodes concernant 58 patients ont été inclus dont 51 ont pu être suivi jusqu'à M1. Les CIVLD étaient utilisés pour l'administration de chimiothérapie (44/60 épisodes, 73 d'alimentation parentérale (6/60, 10, pour un usage mixte (7/60, 12 ou pour un autre usage (3/60, 5. La culture microbiologique mettait en évidence un Staphylocoque à coagulase-négative dans 43% des cas (26/60), une enterobactérie dans 37% des cas (22/60 épisodes), un Pseumononas. aeruginosa dans 8% des cas (5/60), ou une infection polymicrobienne dans 8% des cas (5/60). Le taux d'échec de traitement était de 37% (19/51) parmi les patients ayant complété le suivi. La mortalité toute cause était de 239/51), la mortalité liée à l'infection de CIVLD était de 32/51). Les patients traités pour un cancer solide ou ceux en traitement palliatif avaient un taux d'échec significativement plus élevé (respectivement, p=0,037, p=0,026). Les autres facteurs de fragilité comme la neutropénie ou un score OMS textgreater2 n'étaient pas significativement associés à un plus fort taux d'échec. Par ailleurs, le risque d'échec du verrous ne semblait pas lié à la bactérie. Parmi les patients ayant complété leur traitement, une durée plus courte de verrou antibiotique était significativement associée à un taux de rechute plus élevé (9 vs 14 jours, p=0,033).
Conclusion
Le traitement conservateur des bactériémies liées aux CIVLD semble être efficace avec néanmoins un taux d'échec plus élevé que ceux précédemment rapportés dans la littérature. Être traité pour un cancer solide et être traité moins longtemps semble être associé à un taux d'échec plus élevé. Il serait intéressant d'inclure les infections liées aux cathéters d'hémodialyse de même que les patients d'oncohématologie qui sont pris en charge dans un autre centre hospitalier. Aucun lien d'intérêt
BibTeX:
@article{Marlat2023,
  author = {Marlat, C. and Grosjean, J. and Laffouilhere, T. Pressat and Etienne, M. and Alexandre, K. and Zeggay, A.},
  title = {Traitement conservateur des bactériémies liées aux cathéters veineux de longue-durée.},
  month = {May},
  journal = {Médecine et Maladies Infectieuses Formation},
  year = {2023},
  series = {Journées {Nationales} de l'{Infectiologie}},
  volume = {2},
  number = {2, Supplement},
  pages = {S34},
  url = {https://www.sciencedirect.com/science/article/pii/S2772743223001320},
  doi = {10.1016/j.mmifmc.2023.03.105}
}

BibTeX:
@phdthesis{Meury2023,
  author = {Meury, Pierrette},
  title = {Etat des lieux des exercices infirmiers de santé publique et en pratique avancée, en exercice avec des médecins en structures de soins de santé ambulatoires en {France} et analyse des collaborations au sein des binômes.},
  school = {Antilles},
  year = {2023},
  url = {https://www.theses.fr/s196547}
}

2022


Abstract: Background
Even if English is the leading language for international communication, it is essential to keep in mind that research runs at the local level by local teams generally communicating in their local/national language, especially in Europe among European projects.
Objective
and methods Therefore, the European Federation for Medical Informatics - Working Group on Health Informatics for Inter-regional Cooperation” has one objective: To develop a multilingual ontology focusing on Health Informatics as a collaboration tool that improves international and, in particular, European collaborations.
Results
We have developed the Medical Informatics and Digital Health Multilingual Ontology (MIMO). Hosted on the Health Terminology/Ontology Portal (HeTOP), MIMO contains around 1,000 concepts, 460 MeSH Descriptors, 220 MeSH Concepts, and more than 300 newly created concepts. MIMO is continuously updated to comprise as recent as possible concepts and their translations in more than 30 languages. Moreover, the MIMO’s development team constantly improves MIMO content and supporting information. Thus, during workshop discussions and one-on-one exchanges, the MIMO team has collected domain experts’ opinions about the community’s interests and suggestions for future enhancements. Moreover, MIMO will be integrated to support the annotation and categorization of research products into the HosmartAI European project involving more than 20 countries around Europe and worldwide.
Conclusion
MIMO is hosted by HeTOP (Health Terminology/Ontology Portal), which integrates 100 terminologies and ontologies in 55 languages. MIMO is freely available online. MIMO is portable to other knowledge platforms as part of MIMO’s main aims to facilitate communication between medical librarians, translators, and researchers as well as to support students’ self-learning.
BibTeX:
@article{Benis2022,
  author = {Benis, Arriel and Grosjean, Julien and Billey, Kevin and Gustavo Montanha Meireles Martins, Jose and Dornauer, Verena and Crisan-Vida, Mihaela and Hackl, Werner O. and Stoicu-Tivadar, Lacramioara and Darmoni, Stéfan},
  title = {Medical {Informatics} and {Digital} {Health} {Multilingual} {Ontology} ({MIMO}): a tool to improve international collaborations},
  month = {August},
  journal = {International Journal of Medical Informatics},
  year = {2022},
  pages = {104860},
  url = {https://www.sciencedirect.com/science/article/pii/S1386505622001745},
  doi = {10.1016/j.ijmedinf.2022.104860}
}

Abstract: Real-world evidence (RWE) refers to observational data gathered outside the formalism of randomized controlled trials, in real life situations, on marketed drugs. While clinical trials are the gold standards to demonstrate the efficacy and tolerability of a medicinal product, the generalizability of their results to actual use in real-life is limited by the biases induced by the very nature of clinical trials; indeed, the patients included in the trials may differ from actual users because of their concomitant diseases or treatments, or other factors excluding them from the trials. Clinical researchers and pharmaceutical industries have hence become increasingly interested in expanding and integrating RWE into clinical research, by capitalizing on the exponential growth in access to data from electronic health records, claims databases, electronic devices, software or mobile applications, registries embedded in clinical practice and social media. Meanwhile, applications of RWE may also be used for drug discovery and repurposing, for clinical developments and post-marketing studies. The aim of this review is to provide our opinion regarding the use of RWE in translational research, including non-clinical and clinical pharmacology research, at the different step of drugs development use.
BibTeX:
@article{Charveriat2022,
  author = {Charvériat, Mathieu and Darmoni, Stephan J. and Lafon, Vincent and Moore, Nicholas and Bordet, Régis and Veys, Julien and Mouthon, Franck and in Pharmacology group, S. F. P. T. Translational Research},
  title = {Use of real-world evidence in translational pharmacology research},
  month = {April},
  journal = {Fundamental \& Clinical Pharmacology},
  year = {2022},
  volume = {36},
  number = {2},
  pages = {230--236},
  doi = {10.1111/fcp.12734}
}

Abstract: INTRODUCTION: The aim of this systematic review was to assess the effectiveness of brief interventions realized in primary care in reducing cannabis use for adolescents and emerging adults.
METHODS: PubMed, CINAHL, Embase, PsycInfo, and Central (Cochrane Library) were searched until December 2020. Randomized controlled trials conducted in primary care, concerning in-person brief interventions for non-medical cannabis users aged from 12 to 25 years old were eligible for inclusion. Brief interventions had to last 30 min or less. Patients with comorbid mental health disorder or very specific populations were not included.
RESULTS: One thousand eighty hundred and fifty-five studies were identified through database searching; only 8 studies involving 2,199 patients were included for qualitative synthesis after double reading and data extraction. Randomized controlled trials selected were heterogeneous regarding screening tools, initial levels of cannabis use and cannabis outcomes measures. Brief interventions were all based on motivational interviewing techniques or personalized feedback. Seven studies consisted in a single session of brief intervention. Six studies involved also other substance users. No significant reduction of cannabis use after brief intervention was found for most studies, especially in the long term. A trend of decreased cannabis consequences, such as negative psychosocial repercussions, perception of cannabis use by peers, or driving under the influence of cannabis, was reported.
CONCLUSION: The current state of knowledge does not allow us to say that the brief intervention is effective in reducing cannabis use among adolescents in primary care. We found a mild positive effect on cannabis consequences after brief intervention. Mixed qualitative and quantitative studies are need to better evaluate the impact of brief intervention and his faisability. PROSPERO (International Prospective Register of Systematic Reviews): n° CRD42016033080.
BibTeX:
@article{Chazal2022,
  author = {Chazal, Camille and Roux, Charline and Kinouani, Shérazade and Schuers, Matthieu and Fortin, Frédéric and Pereira, Bruno and Blanc, Olivier and Piñol-Domenech, Nathalie and Brousse, Georges and Vorilhon, Philippe and Laporte, Catherine},
  title = {Effectiveness of brief interventions in primary care for cannabis users aged from 12 to 25 years old: a systematic review},
  month = {November},
  journal = {Family Practice},
  year = {2022},
  volume = {39},
  number = {6},
  pages = {1156--1168},
  doi = {10.1093/fampra/cmac050}
}

BibTeX:
@article{Dezoteux2021,
  author = {Dezoteux, F. and El Mesbahi, S. and Tedbirt, B. and Grosjean, J. and Gautier, S. and Lannoy, D. and Nassar, C. and T{\'e}tart, F. and Staumont-Sall{\'e}, D.},
  title = {Immunomodulatory and/or immunosuppressive drugs should not be stopped prior to skin tests for the assessment of drug allergy},
  month = {April},
  journal = {The British journal of dermatology},
  year = {2022},
  volume = {186},
  number = {4},
  pages = {742-744},
  doi = {10.1111/bjd.20901}
}

Abstract: Background: A major factor in the success of any search engine is the relevance of the search results; a tool should sort the search results to present the most relevant documents first. Assessing the performance of the ranking formula is an important part of search engine evaluation. However, the methods currently used to evaluate ranking formulae mainly collect quantitative data and do not gather qualitative data, which help to understand what needs to be improved to tailor the formulae to their end users.
Objective: This study aims to evaluate 2 different parameter settings of the ranking formula of LiSSa (the French acronym for scientific literature in health care; Department of Medical Informatics and Information), a tool that provides access to health scientific literature in French, to adapt the formula to the needs of the end users.
Methods: To collect quantitative and qualitative data, user tests were carried out with representative end users of LiSSa: 10 general practitioners and 10 registrars. Participants first assessed the relevance of the search results and then rated the ranking criteria used in the 2 formulae. Verbalizations were analyzed to characterize each criterion.
Results: A formula that prioritized articles representing a consensus in the field was preferred. When users assess an article’s relevance, they judge its topic, methods, and value in clinical practice.
Conclusions: Following the evaluation, several improvements were implemented to give more weight to articles that match the search topic and to downgrade articles that have less informative or scientific value for the reader. Applying a qualitative methodology generates valuable user inputs to improve the ranking formula and move toward a highly usable search engine.
BibTeX:
@article{Douze2022,
  author = {Douze, Laura and Pelayo, Sylvia and Messaadi, Nassir and Grosjean, Julien and Kerdelhué, Gaétan and Marcilly, Romaric},
  title = {Designing {Formulae} for {Ranking} {Search} {Results}: {Mixed} {Methods} {Evaluation} {Study}},
  month = {March},
  journal = {JMIR Human Factors},
  year = {2022},
  volume = {9},
  number = {1},
  pages = {e30258},
  note = {Company: JMIR Human Factors Distributor: JMIR Human Factors Institution: JMIR Human Factors Label: JMIR Human Factors Publisher: JMIR Publications Inc., Toronto, Canada},
  url = {https://humanfactors.jmir.org/2022/1/e30258},
  doi = {10.2196/30258}
}

Abstract: INTRODUCTION: Preprints have been widely cited during the COVID-19 pandemics, even in the major medical journals. However, since subsequent publication of preprint is not always mentioned in preprint repositories, some may be inappropriately cited or quoted. Our objectives were to assess the reliability of preprint citations in articles on COVID-19, to the rate of publication of preprints cited in these articles and to compare, if relevant, the content of the preprints to their published version.
METHODS: Articles published on COVID in 2020 in the BMJ, The Lancet, the JAMA and the NEJM were manually screened to identify all articles citing at least one preprint from medRxiv. We searched PubMed, Google and Google Scholar to assess if the preprint had been published in a peer-reviewed journal, and when. Published articles were screened to assess if the title, data or conclusions were identical to the preprint version.
RESULTS: Among the 205 research articles on COVID published by the four major medical journals in 2020, 60 (29.3 cited at least one medRxiv preprint. Among the 182 preprints cited, 124 were published in a peer-reviewed journal, with 51 (41.1 before the citing article was published online and 73 (58.9 later. There were differences in the title, the data or the conclusion between the preprint cited and the published version for nearly half of them. MedRxiv did not mentioned the publication for 53 (42.7 of preprints.
CONCLUSIONS: More than a quarter of preprints citations were inappropriate since preprints were in fact already published at the time of publication of the citing article, often with a different content. Authors and editors should check the accuracy of the citations and of the quotations of preprints before publishing manuscripts that cite them.
BibTeX:
@article{Gehanno2022,
  author = {Gehanno, Jean-Francois and Grosjean, Julien and Darmoni, Stefan J. and Rollin, Laetitia},
  title = {Reliability of citations of {medRxiv} preprints in articles published on {COVID}-19 in the world leading medical journals},
  journal = {PloS One},
  year = {2022},
  volume = {17},
  number = {8},
  pages = {e0264661},
  doi = {10.1371/journal.pone.0264661}
}

Abstract: INTRODUCTION: The cytochrome P450 (CYP450) enzyme system is involved in the metabolism of certain drugs and is responsible for most drug interactions. These interactions result in either an enzymatic inhibition or an enzymatic induction mechanism that has an impact on the therapeutic management of patients. Detecting these drug interactions will allow for better predictability in therapeutic response. Therefore, computerized solutions can represent a valuable help for clinicians in their tasks of detection.
OBJECTIVE: The objective of this study is to provide a structured data-source of interactions involving the CYP450 enzyme system. These interactions are aimed to be integrated in the cross-lingual multi-terminology server HeTOP (Health Terminologies and Ontologies Portal), to support the query processing of the clinical data warehouse (CDW) EDSaN (Entrepôt de Données de Santé Normand).
MATERIAL AND METHODS: A selection and curation of drug components (DCs) that share a relationship with the CYP450 system was performed from several international data sources. The DCs were linked according to the type of relationship which can be substrate, inhibitor, or inducer. These relationships were then integrated into the HeTOP server. To validate the CYP450 relationships, a semantic query was performed on the CDW, whose search engine is founded on HeTOP data (concepts, terms, and relations).
RESULTS: A total of 776 DCs are associated by a new interaction relationship, integrated in HeTOP, by 14 enzymes. These are CYP450 1A2, 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 3A4, 3A7, 11B1,11B2 mitochondrial and P-glycoprotein, constituting a total of 2,088 relationships. A general modelling of cytochromic interactions was performed. From this model, 233,006 queries were processed in less than two hours, demonstrating the usefulness and performance of our CDW implementation. Moreover, they showed that in our university hospital, the concurrent prescription that could cause a cytochromic interaction is Bisoprolol with Amiodarone by enzymatic inhibition for 2,493 patients.
DISCUSSION: The queries submitted to the CDW EDSaN allowed to highlight the most prescribed molecules simultaneously and potentially responsible for cytochromic interactions. In a second step, it would be interesting to evaluate the real clinical impact by looking for possible adverse effects of these interactions in the patients' files. Other computational solutions for cytochromic interactions exist. The impact of CYP450 is particularly important for drugs with narrow therapeutic window (NTW) as they can lead to increased toxicity or therapeutic failure. It is also important to define which drug component is a pro-drug and to considerate the many genetic polymorphisms of patients.
CONCLUSION: The HeTOP server contains a non-negligible number of relationships between drug components and CYP450 from multiple reference sources. These data allow us to query our Clinical Data Warehouse to highlight these cytochromic interactions. It would be interesting in the future to assess the actual clinical impact in hospital reports.
BibTeX:
@article{Gosselin2022,
  author = {Gosselin, Laura and Letord, Catherine and Leguillon, Romain and Soualmia, Lina F. and Dahamna, Badisse and Mouazer, Abdelmalek and Disson, Flavien and Darmoni, Stéfan J. and Grosjean, Julien},
  title = {Modeling and integrating interactions involving the {CYP450} enzyme system in a multi-terminology server: {Contribution} to information extraction from a clinical data warehouse},
  month = {December},
  journal = {International Journal of Medical Informatics},
  year = {2022},
  volume = {170},
  pages = {104976},
  doi = {10.1016/j.ijmedinf.2022.104976}
}

Abstract: BACKGROUND: Whether gastroparesis is associated with a shortened life expectancy remains uncertain as no systematic study has evaluated the impact of gastroparesis on mortality, based on gastric emptying (GE) tests.
AIM: This study aimed to assess whether delayed GE was predictive of mortality.
METHODS: GE was measured using a 13C-octanoic acid breath test in 1563 consecutive patients. Delayed GE at baseline defined the gastroparesis group. Patients were followed up for a mean of 8.9 years, yielding 13 466 patients per year. Mortality was assessed using the French CepiDc database with data from local civil registries. The cause of death was determined from medical records. Mortality rates were assessed using the Kaplan-Meier method and hazard ratio (HR) was calculated using the Cox regression model.
RESULTS: Age and symptoms severity were not different among patients with normal GE (n = 1179) and with delayed GE (n = 384) while diabetes mellitus was more frequent in the gastroparesis group. Kaplan-Meier analysis showed increased mortality in the gastroparesis group compared to patients with normal GE. Cox regression model identified delayed GE as independently associated with increased mortality (HR = 1.63[1.09-2.42]; P = 0.02). Other independent factors associated with increased mortality included age, male sex, and diabetes. No difference was observed between groups for the cause of death, with cancer and cardiovascular disease being the leading causes.
CONCLUSION: This study has shown that gastroparesis, diagnosed on GE tests, was associated with increased mortality, independently of age, sex, BMI or diabetes status (NCT04918329).
BibTeX:
@article{Gourcerol2022,
  author = {Gourcerol, Guillaume and Melchior, Chloé and Wuestenberghs, Fabien and Desprez, Charlotte and Prevost, Gaëtan and Grosjean, Julien and Leroi, Anne Marie and Tavolacci, Marie Pierre},
  title = {Delayed gastric emptying as an independent predictor of mortality in gastroparesis},
  month = {April},
  journal = {Alimentary Pharmacology \& Therapeutics},
  year = {2022},
  volume = {55},
  number = {7},
  pages = {867--875},
  doi = {10.1111/apt.16827}
}

Abstract: BACKGROUND: The diverse and complex variations in the possible forms of health-work interactions are constantly reconfigured over the course of a person's career.
OBJECTIVES: The aims of this study were: 1) assess the scope of the individual changes in working conditions; 2) examine conjoint changes in working conditions; 3) examine the links between these changes and back pain and fatigue.
METHOD: Analyses were conducted using data from the French observatory EVREST. The variations for each individual (close to 8,000 in total) were studied by comparing data for each individual obtained at two dates at least four years apart within the period between 2010 and 2017.
RESULTS: The frequency of the studied constraints was often similar at two dates (T1 and T2), but significantly higher for repetitive movements, working additional hours and interruptions which disrupt the work. The variations in physical constraints, intensity of work and lack of agency scores between the two timepoints are two-by-two positively correlated. Finally, respondents in the higher tertiles for any of these working condition scores at T2 had a higher probability of back pain or fatigue, compared to individuals in the lower tertiles at both timepoints. Being in a higher tertile at both dates corresponded to the highest odds-ratios for health complaints.
CONCLUSION: From a "sustainability" perspective, these findings support treating this diversity of seniority in a profession and past experience at the same time as major decisions on production are made, rather than dealing with it as an afterthought.
BibTeX:
@article{Leroyer2022,
  author = {Leroyer, Ariane and Mardon, Céline and Rollin, Laétitia and Volkoff, Serge},
  title = {Individual changes in working and health conditions: {A} longitudinal study of 8,000 employees between 2010 and 2017 in {France}},
  journal = {Work (Reading, Mass.)},
  year = {2022},
  volume = {73},
  number = {3},
  pages = {1023--1035},
  doi = {10.3233/WOR-210992}
}

Abstract: This multicenter study was conducted in French memory clinics during the first COVID-2019 lockdown (March-May 2020). The objective was to evaluate the effect of a telemedicine consultation on treatment modification in dementia care. Among 874 patients who had a telemedicine consultation, 103 (10.7 …
BibTeX:
@article{Morin2022,
  author = {Morin, A. and Pressat-Laffouilhere, T. and Sarazin, M. and Lagarde, J. and Roue-Jagot, C. and Olivieri, P. and Paquet, C. and Cognat, E. and Dumurgier, J. and Pasquier, F. and Lebouvier, T. and Ceccaldi, M. and Godefroy, O. and Martinaud, O. and Grosjean, J. and Zarea, A. and Maltête, D. and Wallon, D.},
  title = {Telemedicine in {French} {Memory} {Clinics} {During} the {COVID}-19 {Pandemic}},
  month = {December},
  journal = {Journal of Alzheimer's disease : JAD},
  year = {2022},
  volume = {86},
  number = {2},
  note = {Publisher: J Alzheimers Dis},
  url = {https://pubmed.ncbi.nlm.nih.gov/34974434/},
  doi = {10.3233/JAD-215459}
}

Abstract: Polypharmacy, the consuming of more than five drugs, is a public health problem. It can lead to many interactions and adverse drug reactions and is very expensive. Therapeutic guidelines for managing polypharmacy in the elderly have been issued, but are highly complex, limiting their use. Decision-support systems have therefore been developed to automate the execution of these guidelines, or to provide information about drugs adapted to the context of polypharmacy. These systems differ widely in terms of their technical design, knowledge sources and evaluation methods. We present here a scoping review of electronic systems for supporting the management, by healthcare providers, of polypharmacy in elderly patients. Most existing reviews have focused mainly on evaluation results, whereas the present review also describes the technical design of these systems and the methodologies for developing and evaluating them. A systematic bibliographic search identified 19 systems differing considerably in terms of their technical design (rule-based systems, documentary approach, mixed); outputs (textual report, alerts and/or visual approaches); and evaluations (impact on clinical practices, impact on patient outcomes, efficiency and/or user satisfaction). The evaluations performed are minimal (among all the systems identified, only one system has been evaluated according to all the criteria mentioned above) and no machine learning systems and/or conflict management systems were retrieved. This review highlights the need to develop new methodologies, combining various approaches for decision support system in polypharmacy.
BibTeX:
@article{Mouazer2022,
  author = {Mouazer, Abdelmalek and Tsopra, Rosy and Sedki, Karima and Letord, Catherine and Lamy, Jean-Baptiste},
  title = {Decision-support systems for managing polypharmacy in the elderly: {A} scoping review},
  month = {June},
  journal = {Journal of Biomedical Informatics},
  year = {2022},
  volume = {130},
  pages = {104074},
  doi = {10.1016/j.jbi.2022.104074}
}

Abstract: OBJECTIVES: To introduce the 2022 International Medical Informatics Association (IMIA) Yearbook by the editors.
METHODS: The editorial provides an introduction and overview to the 2022 IMIA Yearbook whose special topic is "Inclusive Digital Health: Addressing Equity, Literacy, and Bias for Resilient Health Systems". The special topic, survey papers, section editor synopses and some best papers are discussed. The sections' changes in the Yearbook Editorial Committee are also described.
RESULTS: As shown in the previous edition, health informatics in the context of a global pandemic has led to the development of ways to collect, standardize, disseminate and reuse data worldwide. The Corona Virus Disease 2019 (COVID-19) pandemic has demonstrated the need for timely, reliable, open, and globally available information to support decision making. It has also highlighted the need to address social inequities and disparities in access to care across communities. This edition of the Yearbook acknowledges the fact that much work has been done to study health equity in recent years in the various fields of health informatics research.
CONCLUSION: There is a strong desire to better consider disparities between populations to avoid biases being induced in Artificial Intelligence algorithms in particular. Telemedicine and m-health must be more inclusive for people with disabilities or living in isolated geographical areas.
BibTeX:
@article{Mougin2022,
  author = {Mougin, Fleur and Hollis, Kate Fultz and Soualmia, Lina F.},
  title = {Inclusive {Digital} {Health}},
  month = {August},
  journal = {Yearbook of Medical Informatics},
  year = {2022},
  volume = {31},
  number = {1},
  pages = {2--6},
  doi = {10.1055/s-0042-1742540}
}

Abstract: Acute respiratory infections (ARIs) need to be better understood and treated, as they are critical to public health, especially during crises such as the SARS-CoV2 pandemic. These are the most abundant infections in the general population and are seen primarily in primary care by general practitioners (GPs). Many different viruses are involved, according to epidemic variations. Viral co-detections account for a significant proportion of ARIs in hospital cohorts. The objective of the ECOVIR cohort was to study viral co-detections by setting up a biobank of respiratory tract samples from patients consulting their general practitioner for ARI symptoms. We report here on the course of the study: the design, the conduct, and the difficulties encountered. ECOVIR (Etude des CO-detections VIrales dans les prélèvements Respiratoires) was a prospective, multicenter cohort conducted in France during two epidemic seasons (2018-2019 and 2019-2020). We recruited GPs. Each GP investigator (GPI) saw patients weekly for examination, clinical data collection, and nasopharyngeal swabbing. Each sample was sent to the virology unit for biobanking and molecular analysis. Clinical and sociodemographic data were collected 7 days after inclusion. ECOVIR involved 36 GPIs. Patients with symptoms of an ARI were included (n = 685). The median number of inclusions was 16 patients per GPI over both seasons (IC25-75% [4.75; 27]). Patients aged 18 to 64 years were the most numerous (57, followed by children (30, and the elderly (13% over 65 years). This age distribution emphasizes the young adult and middle-aged population. Residents participated in the project and called patients on day 7 to obtain clinical and sociodemographic data. Our study triggered the creation of an original network, which plans to establish a functional link between research and primary health care. Primary care is unfortunately poorly represented in research protocols, particularly in respiratory infections, even though it is a cornerstone of our French health care system, as demonstrated every day in this period of crisis.
BibTeX:
@article{Petat2022a,
  author = {Petat, Hortense and Schuers, Matthieu and Corbet, Sandrine and Humbert, Xavier and Le Bas, François and Marguet, Christophe and Pellerin, Lucille and Rabiaza, Andry and Vabret, Astrid and Ar Gouilh, Meriadeg},
  title = {The {Design} and {Implementation} of the {ECOVIR} {Project}: {A} {Primary} {Health} {Care} {Surveillance} {System} to {Strengthen} {Co}-{Detection} of {Respiratory} {Viruses} in {Normandy}},
  month = {December},
  journal = {Methods and Protocols},
  year = {2022},
  volume = {5},
  number = {6},
  pages = {98},
  doi = {10.3390/mps5060098}
}

Abstract: Our study confirmed the diversity of NIPs, including in neighboring European countries with similar factors like economic resources and epidemiological risk, thus indicating that other factors underlie NIPs. Convergence toward a more common immunization program including MenACWY and MenB vaccination …
BibTeX:
@article{PintoCardoso2022,
  author = {Pinto Cardoso, G. and Lagrée-Chastan, M. and Caseris, M. and Gaudelus, J. and Haas, H. and Jp, Leroy and Bakhache, P. and Jf, Pujol and Werner, A. and Ma, Dommergues and Pauquet, E. and Pinquier, D.},
  title = {Overview of meningococcal epidemiology and national immunization programs in children and adolescents in 8 {Western} {European} countries},
  month = {November},
  journal = {Frontiers in pediatrics},
  year = {2022},
  volume = {10},
  note = {Publisher: Front Pediatr},
  url = {https://pubmed.ncbi.nlm.nih.gov/36507149/},
  doi = {10.3389/fped.2022.1000657}
}

Abstract: BACKGROUND: Unstructured data from electronic health records represent a wealth of information. Doc'EDS is a pre-screening tool based on textual and semantic analysis. The Doc'EDS system provides a graphic user interface to search documents in French. The aim of this study was to present the Doc'EDS tool and to provide a formal evaluation of its semantic features.
METHODS: Doc'EDS is a search tool built on top of the clinical data warehouse developed at Rouen University Hospital. This tool is a multilevel search engine combining structured and unstructured data. It also provides basic analytical features and semantic utilities. A formal evaluation was conducted to measure the impact of Natural Language Processing algorithms.
RESULTS: Approximately 18.1 million narrative documents are stored in Doc'EDS. The formal evaluation was conducted in 5000 clinical concepts that were manually collected. The F-measures of negative concepts and hypothetical concepts were respectively 0.89 and 0.57.
CONCLUSION: In this formal evaluation, we have shown that Doc'EDS is able to deal with language subtleties to enhance an advanced full text search in French health documents. The Doc'EDS tool is currently used on a daily basis to help researchers to identify patient cohorts thanks to unstructured data.
BibTeX:
@article{Pressat-Laffouilhere2020,
  author = {Pressat-Laffouilhère, Thibaut and Balayé, Pierre and Dahamna, Badisse and Lelong, Romain and Billey, Kévin and Darmoni, Stéfan J. and Grosjean, Julien},
  title = {Evaluation of {Doc}'{EDS}: a {French} semantic search tool to query health documents from a clinical data warehouse},
  month = {February},
  journal = {BMC medical informatics and decision making},
  year = {2022},
  volume = {22},
  number = {1},
  pages = {34},
  doi = {10.1186/s12911-022-01762-4}
}

Abstract: INTRODUCTION: Radical prostatectomy (RP) can generate multidimensional physiological changes, like decrease in physical and emotional functioning, as well as Health Related Quality of Life (HRQoL). However, only pelvic floor muscle training (PFMT) is commonly recommended as conservative treatment after RP. More comprehensive interventions than only PFMT, such as physiotherapy promoting general coordination, flexibility, strength, endurance, fitness and functional capacity may seem more relevant and patient-centered.
AIM OF THE REVIEW: Our aim was to evaluate whether a more Comprehensive Functional Physical Therapy (CFPT) than PFMT alone, focused on lower limb and lumbo-pelvic exercises, would improve physical capacities and functions (including urinary continence (UI)), emotional functions and HRQoL in patients after RP.
EVIDENCE ACQUISITION: A systematic review was performed in accordance with the PRISMA reporting guidelines. A literature search was conducted in PubMed, PEDro, Web of Science and Cochrane Library databases from inception to January 2022. The PICO approach was used to determine the eligibility criteria. According to the quality of selected studies, levels of evidence were given.
EVIDENCE SYNTHESIS: Eight clinical trials met the eligibility criteria. Regarding UI, all the studies reported positive outcomes for CFPT between pre- and post-physiotherapy (Ptextless0.05). The selected studies reported positive outcomes for physical capacities as well as for physical and emotional functioning, and for HRQoL (Ptextless0.05).
CONCLUSION: Current literature indicates that CFPT was shown to be safe, non-invasive, and particularly effective in terms of UI recovery. CFPT could result in more positive outcomes, including physical capacities, physical and emotional functioning and HRQoL, than PFMT alone. Further standardized, physiotherapist-guided and well-designed clinical trials conducted by experienced multidisciplinary clinicians are still called for.
BibTeX:
@article{Steenstrup2022,
  author = {Steenstrup, B. and Cartier, M. and Nouhaud, F. X. and Kerdelhue, G. and Gilliaux, M.},
  title = {A systematic review of supervised comprehensive functional physiotherapy after radical prostatectomy},
  month = {July},
  journal = {Progres En Urologie: Journal De l'Association Francaise D'urologie Et De La Societe Francaise D'urologie},
  year = {2022},
  volume = {32},
  number = {7},
  pages = {525--539},
  doi = {10.1016/j.purol.2022.04.008}
}

Abstract: Résumé
Objectifs
Déterminer les besoins du suivi médical par la médecine du travail chez les externes en médecine. Recueillir leurs perceptions par rapport à leurs études, connaître leurs points de vue et leurs connaissances sur la médecine du travail et enfin, améliorer le suivi médical des externes afin de limiter les risques psychosociaux.
Méthode
Il s’agissait d’une étude observationnelle épidémiologique analytique, de cohorte, rétrospective et monocentrique. Durant la période de février 2020 à décembre 2020, les étudiants de la 4e à la 6e année de Médecine du CHU de Rouen remplissaient un questionnaire spécifiquement créé pour l’étude comprenant le questionnaire HAD versant dépression.
Résultats
Au total, 494 étudiants sur 840 ont participé à l’étude, soit un taux de participation de 59 %. Parmi ceux-ci, le manque de reconnaissance au travail était déclaré par 94  le fait d’avoir fait des sacrifices pour continuer médecine par 85 %. Ils étaient 43 % à ne pas recommander leurs études aux lycéens et 24 % ne referaient pas médecine. L’anxiété, la fatigue chronique, la surcharge de travail et les troubles du sommeil touchaient respectivement 82  70  65 % et 41 % des étudiants et 31 % voyaient un spécialiste pour discuter de leurs études. La consommation de substance pour supporter les études était déclarée par 18 % des étudiants. Enfin, 71 % trouvaient que le suivi en médecine du travail était inadapté ou inexistant. Ils estimaient que le manque de temps et la méconnaissance du rôle de la médecine du travail limitaient le suivi.
Conclusion
Cette enquête a permis de montrer qu’il existait encore beaucoup de mal-être chez les étudiants, qu’ils étaient toujours confrontés à de nombreuses difficultés. Les risques psychosociaux, apparaissent dès le début des études médicales et il est important d’agir dès que possible. La médecine du travail est un élément important du suivi de la santé des étudiants en médecine. La visite d’embauche sera extrêmement importante dans la prise en charge des étudiants. La mise en place de séances d’informations entre les cours, de flyers ou d’affiches pour communiquer sur le rôle et les missions du service permettront une information pour les étudiants.
Summary
Background
Determine the needs for medical follow-up by occupational medicine among Medicine students. Collect their feelings about their studies, know their point of view and their knowledge about occupational medicine and finally improve the medical follow-up of externs in order to limit psycho-social risks.
Method
This was an analytical, cohort, retrospective, single-center, epidemiological observational study. Between February 2020 and September 2020, Medicine students from 4th to 6th year of the studies completed a questionnaire specifically created for the study including the HAD depression questionnaire.
Results
Among the 494 participating students, the lack of recognition at work was declared by 94 the fact of having made sacrifices to continue medicine by 85%. They were 43% not to recommend their studies to high school students and 24% would not return to medicine. Anxiety, chronic fatigue, work overload and sleep disturbances affected 82 70 65% and 41% of students, respectively, and 31% saw a specialist to discuss their studies. Substance consumption to support studies was reported by 18% of students. Finally, 71% found that occupational health follow-up was inadequate or non-existent. They felt that the lack of time and the lack of knowledge of the role of occupational medicine limited follow-up.
Conclusions
Occupational medicine is an important part of monitoring the health of medical students. The employment visit will be extremely important in the care of the students. This survey showed that there was still a lot of discomfort among students, that they still face many difficulties. The psycho-social risks appear early in medical studies and it is important to act as soon as possible. The setting up of information sessions between classes, flyers or posters to communicate on the role and missions of the service will allow students to be informed.
BibTeX:
@article{Maufroid2022,
  author = {Maufroid, V. and Boyer, A. F. and Gehanno, J. F. and Rollin, L.},
  title = {Étude sur la perception des étudiants en médecine de {Rouen} à propos de leur externat, de leur état de santé général ainsi que leurs liens avec la médecine du travail},
  month = {October},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2022},
  volume = {83},
  number = {5},
  pages = {472--482},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878522000832},
  doi = {10.1016/j.admp.2022.05.003}
}

BibTeX:
@article{Mornex2022,
  author = {Mornex, J.-F. and Balduyck, M. and Bouchecareilh, M. and Cuvelier, A. and Epaud, R. and Kerjouan, M. and Le Rouzic, O. and Pison, C. and Plantier, L. and Pujazon, M.-C. and Reynaud-Gaubert, M. and Toutain, A. and Trumbic, B. and Willemin, M.-C. and Zysman, M. and Brun, O. and Campana, M. and Chabot, F. and Chamouard, V. and Dechomet, M. and Fauve, J. and Girerd, B. and Gnakamene, C. and Lefrançois, S. and Lombard, J.-N. and Maitre, B. and Maynié-François, C. and Moerman, A. and Payancé, A. and Reix, P. and Revel, D. and Revel, M.-P. and Schuers, M. and Terrioux, P. and Theron, D. and Willersinn, F. and Cottin, V. and Mal, H.},
  title = {Atteinte pulmonaire du déficit en alpha-1 antitrypsine. {Recommandations} pratiques pour le diagnostic et la prise en charge},
  month = {July},
  journal = {Rev Mal Respir},
  year = {2022},
  pages = {S0761--8425(22)00233--9},
  doi = {10.1016/j.rmr.2022.06.002}
}

Abstract: Comprendre et traiter les infections respiratoires aiguës (IRA) sont un enjeu majeur de santé publique, particulièrement en cette période de pandémie à SARS-CoV2. ECOVIR (Étude des co-détections virales dans les prélèvements respiratoires), est une étude prospective, multicentrique, en Normandie, sur deux saisons hivernales (2018–2019 et 2019–2020). L’objectif de ce projet était de créer une biothèque de prélèvements respiratoires à partir d’une cohorte de patients consultant leur médecin traitant pour des symptômes d’IRA, permettant d’étudier les co-détections virales. Trente-six médecins généralistes investigateurs (MGI), dans 8 maisons de santé normandes, ont participé à l’étude. Au total, 685 patients ont été inclus, présentant des symptômes d’IRA, et ont bénéficié d’un prélèvement nasopharyngé au cabinet médical par les MGI pour analyse virologique. Trente et un MGI/36 ont inclus des patients. La médiane d’inclusion était de 16 patients par MGI sur les 2 saisons (IC25–75 % [4,75 ; 27]). De plus, 92 % des patients ont répondu à l’appel à j7, recueillant des données cliniques, environnementales, et sociodémographiques. Nous avons donc créé un vrai réseau, original, permettant d’assurer un lien entre la recherche et les soins primaires, peu représentés dans les protocoles de recherche mais qui sont la pierre angulaire de notre système de santé en France, comme nous le constatons actuellement avec la crise sanitaire.
BibTeX:
@article{Petat2022,
  author = {Petat, H. and Schuers, M. and Rabiaza, A. and Marguet, C. and Pellerin, L. and Le Bas, F. and Humbert, X. and Corbet, S. and Deseille, B. and Gosse, L. and Lambert, P.-A. and Poupon, T. and Vervisch, E. and Morello, R. and Chaillot, F. and Ecovir, M. and Vabret, A. and Le Gouil, M.},
  title = {{ECOVIR} : mise en place d’une cohorte en soins primaires, un exemple de coopération pluri-professionnelle ville-hôpital},
  month = {March},
  journal = {Revue Des Maladies Respiratoires},
  year = {2022},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916614/},
  doi = {10.1016/j.rmr.2022.02.060}
}

Abstract: Résumé
Introduction
Les asthmes sont la cause la plus fréquente de maladie respiratoire professionnelle dans les pays industrialisés. Les données épidémiologiques sur la prédominance d’un genre au sein de la population de travailleurs atteints d’asthme en relation avec le travail (ART) sont contradictoires, les données les plus récentes suggérant toutefois une prédominance féminine. L’objectif de notre étude est de comparer par sexe, les expositions et les secteurs d’activités au sein d’une population française de travailleurs ayant consulté pour un ART.
Méthodes
Nous avons recensé les cas d’ART (Codes J45, U05, J68 de la CIM-10) enregistrés entre 2001 et 2018 dans la base du RNV3P (Réseau national de vigilance et de prévention des pathologies professionnelles). Les paramètres étudiés étaient les données démographiques du patient, les expositions professionnelles, les postes de travail et le secteur d’activité. Seules les expositions avec une imputabilité jugée moyenne ou forte par le clinicien ont été retenues.
Résultats
Entre 2001 et 2018, 8385 cas d’ART ont été enregistrés, majoritairement chez les hommes (54,5  ; 13,5 % étaient des asthmes aux irritants. Une tendance à la diminution du nombre d’ART a été constatée sur la période. Les femmes souffrant d’ART exerçaient significativement plus dans les secteurs de la coiffure, des activités hospitalières et étaient principalement exposées aux composés d’ammonium quaternaire, aux produits d’entretien et détergents pour locaux. Les hommes étaient significativement plus représentés dans la boulangerie et le secteur du bâtiment et travaux publics (BTP), et majoritairement exposés aux poussières de farines, aux cyanates et isocyanates.
Conclusion
Notre étude confirme des différences en fonction du genre en termes d’expositions et de secteurs d’activités à l’origine d’ART. Il apparaît nécessaire de tenir compte des spécificités des ART dans les deux sexes afin d’établir rapidement le lien entre une exposition, un secteur d’activité et l’apparition ou l’aggravation d’un asthme.
Summary
Work related asthma in women: compared to data in men. Retrospect data study carried out by the RNV3P: National Network Watch and Prevention of Work related Pathologies.
Introduction
Asthma is the leading cause of work related pathologies in industrialized countries. Epidemiological data on the predominance of a certain gender among workers with asthma among workers suffering from this disease is contradictory though the most recent studies seem to indicate an added frequency among female workers. The purpose of our study is to compare by sex, exposures and sectors of activity among the French population of workers who came for work-related asthma diagnosis.
Method
We tabulated recent work-related asthma cases (J45, U05, J68 of the CIM-10) recorded between 2001 and 2018 in the RNV3P (National Network Watch and Prevention of Work-related Pathologies). The following parameters were looked at: demographic patients data, professional exposures, workstations and sector of activity. We retained only the medium to strong impacts.
Results
During the period studied, 8385 WRA cases were recorded, mainly among men (54.5, 13.5% of which due to irritants. We noticed a decrease of the number of cases over the years. Women suffering from WRA were most significantly found in the following sectors: hairdressing salons, hospital activities, mainly exposed to quaternary ammonium components and housecleaning products and detergents. Men were more significantly impacted while working in bread-making activity due to various flour dusts, and in construction with cyanate and isocyanates.
Conclusion
Our study confirms sex is a variable in term of exposure and sectors of activity when it comes to WRA. It seems necessary to take this into account in both sexes in order to rapidly link them to the outset or worsening of asthma.
BibTeX:
@article{Robin2022,
  author = {Robin, C. and Vongmany, N. and Dewitte, J. D. and Lodde, B. and Larabi, L. and Lucas, D.},
  title = {Asthmes en relation avec le travail chez la femme : comparaison aux données masculines. Étude rétrospective des données issues du {Réseau} national de vigilance et de prévention des pathologies professionnelles ({RNV3P})},
  month = {June},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2022},
  volume = {83},
  number = {3},
  pages = {181--192},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878522000364},
  doi = {10.1016/j.admp.2022.01.013}
}

Abstract: OBJECTIVES: To describe psychosocial constraints and mental health of hospital workers, and to identify the psychosocial constraints significantly associated with mental health difficulties, especially in two groups: caregivers and other hospital workers.
METHOD: Data about working conditions and health status collected by the Evrest National observatory in 2018-2019 during occupational health consultation were used. Psychosocial constraints and mental health among caregivers, other hospital workers and non-hospital workers were described.
RESULTS: There were 1251 hospital workers (843 caregivers, 408 other hospital workers) and 25 129 other workers. Intensity and working time (time pressure, extra working time, missing or shortening a meal), and ethical dilemmas (not having the means to ensure high-quality work, too rapidly handling a procedure that would require more painstaking care) were significantly more reported by the caregivers than by the other hospital workers (50.8% vs 44.2 43.4% vs 32.5 47.2% vs 17.2 21.4% vs 16.4% and 41.5% vs 29.0% respectively). Prevalence of psychological distress was not significantly higher for caregivers (12.3 than for other hospital workers (12.4 but was significantly higher than for other workers (7.3. For caregivers, factors significantly associated with psychological distress were time pressure (Odds Ratio adjusted on sociodemographic factors (OR) = 2.33 CI95% [1.35-4.04]), "difficulties to reconcile private life and work life" (OR = 2.95 [1.54-5.69]), "work not recognized in the professional setting" (OR = 1.89 [1.08-3.31]) and "fear of losing one's job" (OR = 2.98 [1.53-5.8]). For other hospital workers, they were "difficulties to reconcile private life and work life (OR = 2.76 [1.04-7.30]), "insufficient possibilities of mutual aid" (OR = 2.85 [1.24-6.53] and "not having the means to ensure high-quality work" (OR = 3.42 [1.62-7.21]).
CONCLUSION: Factors significantly associated with psychological distress were not the same for caregivers and other hospital workers, nor were they the most frequently reported. Detailed description of the constraints according to group of workers could help to develop a high-priority preventive program regarding psychosocial risk factors.
BibTeX:
@article{Rollin2022,
  author = {Rollin, Laetitia and Gehanno, Jean-François and Leroyer, Ariane},
  title = {Occupational stressors in healthcare workers in {France}},
  month = {March},
  journal = {Revue D'epidemiologie Et De Sante Publique},
  year = {2022},
  pages = {S0398--7620(22)00160--2},
  doi = {10.1016/j.respe.2022.02.002}
}

Abstract: Objectif
L’objectif de cette revue était de préciser l’association potentielle entre l’évolution des courbures vertébrales liées à l’âge et le risque de prolapsus des organes pelviens chez les femmes.
Méthode
Une revue systématique PRISMA a été effectuée. Les mots clés ont été choisis en accord avec les critères d’éligibilité PICO. Pour être incluses, les études devaient être des cohortes observationnelles, des études de cas témoins ou des études transversales. La qualité des articles a été évaluée à l’aide de l’échelle STROBE.
Résultats
Cinq articles de 1996 à 2021 ont été inclus dans la présente revue avec des résultats conflictuels. Quatre études ont rapporté une association positive entre les prolapsus anatomiques à l’examen clinique, une diminution de la lordose lombaire et une augmentation de la cyphose thoracique. L’étude restante, basée sur l’évaluation des symptômes par questionnaire, n’a trouvé aucune association entre les symptômes liés aux prolapsus des organes pelviens et les modifications des courbures de la colonne vertébrale liées à l’âge.
Conclusion
D’après les données disponibles, cette revue suggère une preuve très modérée d’association entre le développement de prolapsus des organes pelviens anatomique et les modifications de courbures sagittales vertébrales liées à l’âge chez la femme. Cette revue reste limitée par le faible nombre et l’hétérogénéité des études incluses. Des études complémentaires, si possible longitudinales, avec des protocoles de bonne qualité méthodologique, devraient être menées pour une meilleure compréhension de la physiopathologie des prolapsus des organes pelviens.
BibTeX:
@article{Steenstrup2022a,
  author = {Steenstrup, B. and Cornu, J. N. and Poilvet, E. and Breard, H. and Kerdelhue, G. and Gilliaux, M.},
  title = {Impact des modifications des courbures vertébrales sagittales liées à l’âge sur les prolapsus des organes pelviens. {Une} revue systématique de la littérature},
  month = {July},
  journal = {Progres En Urologie: Journal De l'Association Francaise D'urologie Et De La Societe Francaise D'urologie},
  year = {2022},
  volume = {32},
  number = {7},
  pages = {516--524},
  doi = {10.1016/j.purol.2022.02.003}
}

Abstract: Résumé
Introduction
Les expositions professionnelles des chauffeurs de bus urbain et leurs conséquences sur la santé restent mal caractérisées et l’imputabilité de certaines pathologies est parfois plus difficile à établir que pour d’autres catégories de conducteurs de véhicules lourds. L’objectif de cette étude était de décrire les expositions professionnelles et d’état de santé des chauffeurs de bus urbains en les comparant à d’autres catégories de conducteurs de véhicules lourds.
Méthodes
Une étude épidémiologique descriptive à partir des données des enquêtes Evrest (n=2494), Sumer 2010 (n=566) et Sumer 2017 (n=387) a permis de comparer les expositions professionnelles et la santé de différentes catégories de conducteurs de véhicules lourds (bus urbain, bus interurbain, fret interurbain et frets urbain).
Résultats
Une prévalence supérieure d’atteintes du rachis cervical ainsi que de troubles d’ordre psychologique est mise en évidence chez les chauffeurs de bus urbains comparativement aux trois autres métiers de la conduite étudiés. Aucune différence n’est retrouvée en termes de prévalence des lombalgies avec les chauffeurs poids lourds qui peuvent bénéficier d’une reconnaissance en maladie professionnelle des radiculalgies sur hernies discales lombaires. Le métier de chauffeur de bus urbains offre une faible latitude décisionnelle ainsi qu’une pression psychologique importante en lien avec les impératifs horaires et le contact avec le public. Ces constatations pourraient expliquer les atteintes à l’état de santé des chauffeurs de bus urbains retrouvées dans cette étude.
Discussion
Il est nécessaire d’approfondir nos connaissances sur les expositions professionnelles des chauffeurs de bus urbains par la réalisation d’études ciblées afin d’identifier les facteurs de risque d’altération de la santé et d’améliorer la prévention.
Summary
Introduction
The occupational exposure of urban bus drivers and their consequences on health remain poorly studied and the imputability of occupational pathologies is sometimes more difficult to establish than for other categories of heavy vehicle drivers. The aim of this study was to describe the occupational exposure and health status of urban bus drivers by comparing them to other categories of heavy vehicle drivers.
Methods
A descriptive epidemiological study using data from the EVREST (n=2494), Sumer 2010 (n=566) and Sumer 2017 (n=387) surveys compared the occupational exposure and health of different categories of heavy vehicle drivers (urban bus, intercity bus, intercity freight and urban freight).
Results
A higher prevalence of cervical spine disorders and psychological disorders was found among urban bus drivers compared to the other three driving occupations studied. No difference was found in terms of prevalence of low back pain with truck drivers, who can benefit from compensation of lumbar radiculopathy due to disc herniation as an occupational disease. Urban bus driver activity offers low decisional latitude combined with significant psychological demand due to the time constraints and contact with the public. These findings could explain the prevalence of health impairment among urban bus drivers identified in this study.
Discussion
There is a need to improve knowledge of the occupational exposure of urban bus drivers through specific studies to identify risk factors for health impairment and to improve prevention.
BibTeX:
@article{Wei2022,
  author = {Wei, K. and Fort, E. and Rollin, L. and Leroyer, A. and Charbotel, B.},
  title = {Expositions professionnelles et santé des conducteurs professionnels, quelles spécificités pour les chauffeurs de bus urbains ?},
  month = {October},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2022},
  volume = {83},
  number = {5},
  pages = {458--471},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878522000467},
  doi = {10.1016/j.admp.2022.03.001}
}

Abstract: The purpose of this study was to evaluate the reliability and reproducibility of a novel approach for base and neck fractures of the mandible. An anatomical study was conducted on 22 given to Science subjects. A rhytidectomy-like approach was performed, followed by a transmasseteric anteroparotid dissection. Measures were taken of the incision length and bone exposure at every step. The identification of a ramus of the facial nerve during dissection was noted. The subjects were classified according to their facial adiposity. A correlation coefficient was measured between incision length and bone exposure as well as morphotype and bone exposure. Statistical analysis was carried out using the Pearson method for linear correlation, and Chi2 test for further analysis. Adequate condylar exposure was always achieved in the area of interest (i.e. in the main localization of base and neck fractures). There was no correlation between the length of the cranial cutaneous backcut and the bone exposure horizontally (p = 0.3296) or vertically (p = 0.8382). There was no correlation between the total length of the incision and the bone exposure horizontally (p = 0.5171) or vertically (p = 0.8404). There was a significant correlation between the subjects' facial adiposity and the bone exposure horizontally and vertically (ptextless0.005). This approach allowed adequate bone exposure to the mandible base and neck, with a possible 90° angulation of instruments for optimal bone fixation. The incidence of facial nerve rami identification during dissection was similar to other approaches. The scarring was hidden. These results allowed us to propose this approach in a clinical study.
BibTeX:
@article{BenSlama2022,
  author = {Ben Slama, Neil and Crampon, Frederic and Maquet, Charles and Derombise, Baptiste and Duparc, Fabrice and Trost, Olivier},
  title = {Preauricular anteroparotid transmasseteric approach of the mandibular condyle: {The} natural evolution after cervical dissections? {An} anatomical feasibility study},
  month = {October},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2022},
  volume = {123},
  number = {5},
  pages = {e598--e603},
  doi = {10.1016/j.jormas.2022.05.006}
}

Abstract: A large number of Electronic Medical Records (EMR) are currently available with a variety of features and architectures. Existing studies and frameworks presented some solutions to overcome the problem of specification and application of clinical guidelines toward the automation of their use at the point of care. However, they could not yet support thoroughly the dynamic use of medical knowledge in EMRs according to the clinical contexts and provide local application of international recommendations. This study presents the development of the Clinical Knowledge Platform (CKP): a collaborative interoperable environment to create, use, and share sets of information elements that we entitled Clinical Use Contexts (CUCs). A CUC could include medical forms, patient dashboards, and order sets that are usable in various EMRs. For this purpose, we have identified and developed three basic requirements: an interoperable, inter-mapped dictionary of concepts leaning on standard terminologies, the possibility to define relevant clinical contexts, and an interface for collaborative content production via communities of professionals. Community members work together to create and/or modify, CUCs based on different clinical contexts. These CUCs will then be uploaded to be used in clinical applications in various EMRs. With this method, each CUC is, on the one hand, specific to a clinical context and on the other hand, could be adapted to the local practice conditions and constraints. Once a CUC has been developed, it could be shared with other potential users that can consume it directly or modify it according to their needs.
BibTeX:
@article{Dahlweid2022,
  author = {Dahlweid, Michael and Rausch, Dennis and Hinske, Christian and Darmoni, Stefan and Grosjean, Julien and Santi, Jonni and Marin, Lise and Yasini, Mobin},
  title = {Clinical {Knowledge} {Platform} ({CKP}): {A} {Collaborative} {Ecosystem} to {Share} {Interoperable} {Clinical} {Forms}, {Viewers}, and {Order} {Sets} with {Various} {EMRs}},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {298},
  pages = {117--121},
  doi = {10.3233/SHTI220919}
}

Abstract: The aim of this paper is to present the use of Medical Informatics Multilingual Ontology (MIMO) to index digital health resources that are (and will be) included in SaNuRN (project to teach digital health). MIMO currently contains 1,379 concepts and is integrated into HeTOP, which is a cross-lingual multiterminogy server. Existing teaching resources have been reindexed with MIMO concepts and integrated into a dedicated website. A total of 345 resources have been indexed with MIMO concepts and are freely available at https://doccismef.chu-rouen.fr/dc/env=sanurn. The development of a multilingual MIMO for enhancing the quality and the efficiency of international projects is challenging. A specific semantic search engine has been deployed to give access to digital health teaching resources.
BibTeX:
@article{Darmoni2022,
  author = {Darmoni, Stéfan and Benis, Arriel and Lejeune, Emeline and Disson, Flavien and Dahamna, Badisse and Weber, Patrick and Staccini, Pascal and Grosjean, Julien},
  title = {Digital {Health} {Multilingual} {Ontology} to {Index} {Teaching} {Resources}},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {298},
  pages = {19--23},
  doi = {10.3233/SHTI220900}
}

Abstract: The ReMIAMes project proposes a methodological framework to provide a reliable and reproducible measurement of the frequency of drug-drug interactions (DDI) when performed on real-world data. This framework relies on (i) a fine-grained and contextualized definition of DDIs, (ii) a shared minimum information model to select the appropriate data for the correct interpretation of potential DDIs, (iii) an ontology-based inference module able to handle missing data to classify prescription lines with potential DDIs, (iv) a report generator giving the value of the measurement and explanations when potential false positive are detected due to a lack of available data. All the tools developed are intended to be publicly shared under open license.
BibTeX:
@article{Duclos2022,
  author = {Duclos, Catherine and Griffon, Nicolas and Daniel, Christel and Bouzillé, Guillaume and Delamarre, Denis and Darmoni, Stefan and Toubiana, Laurent and Grosjean, Julien},
  title = {Reliability of {Drug}-{Drug} {Interaction} {Measurement} on {Real}-{Word} {Data}: {The} {ReMIAMes} {Project}},
  month = {May},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {294},
  pages = {151--152},
  doi = {10.3233/SHTI220425}
}

Abstract: OBJECTIVE: The aim of this paper is to propose an extended translation of the MeSH thesaurus based on Wikipedia pages.
METHODS: A mapping was realized between each MeSH descriptor (preferred terms and synonyms) and corresponding Wikipedia pages.
RESULTS: A tool called "WikiMeSH" has been developed. Among the top 20 languages of this study, seven have currently no MeSH translations: Arabic, Catalan, Farsi (Iran), Mandarin Chinese, Korean, Serbian, and Ukrainian. For these seven languages, WikiMeSH is proposing a translation for 47% for Arabic to 34% for Serbian.
CONCLUSION: WikiMeSH is an interesting tool to translate the MeSH thesaurus and other health terminologies and ontologies based on a mapping to Wikipedia pages.
BibTeX:
@article{Dusenne2022,
  author = {Dusenne, Mikaël and Billey, Kévin and Desgrippes, Florent and Benis, Arriel and Darmoni, Stéfan Jacques and Grosjean, Julien},
  title = {{WikiMeSH}: {Multi} {Lingual} {MeSH} {Translations} via {Wikipedia}},
  month = {May},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {294},
  pages = {403--404},
  doi = {10.3233/SHTI220483}
}

Abstract: Clinical Data Warehouses (CDW) are gold mines and may be useful to manage the COVID-19 outbreak. This article details the use of CDW in order to retrieve patients for vaccination purposes. A list of 34 diseases (or conditions) was published by French Health Authorities to target individuals at a high risk of developing a severe form of COVID. Using a multilevel search engine, 23 queries were built based on structured or unstructured data using natural language processing features. The Diagnosis Related Group coding system was used alone in three queries (13.0, coupled with unstructured data in four queries (17.4, and unstructured data were used alone in 16 queries (69.6. Eleven diseases (conditions) were too broad to be translated into queries. Finally, 6,006 unique re-identified patients were retrieved. This use case demonstrates the usefulness of the Rouen University Hospital CDW in retrieving patients for other purposes than translational research.
BibTeX:
@article{Grosjean2021,
  author = {Grosjean, Julien and Pressat-Laffouilhère, Thibaut and Ndangang, Marie and Leroy, Jean-Philippe and Darmoni, Stéfan J.},
  title = {Using {Clinical} {Data} {Warehouse} to {Optimize} the {Vaccination} {Strategy} {Against} {COVID}-19: {A} {Use} {Case} in {France}},
  month = {June},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {290},
  pages = {150--153},
  doi = {10.3233/SHTI220050}
}

Abstract: INTRODUCTION: The management of patients with inherited bleeding disorders in oral surgery requires the systematic evaluation of bleeding risk and the setting up of an adequate treatment protocol by the referring haematologist, defining a replacement therapy and a recommended length of hospital stay. The purpose of this study was to determine the bleeding risk associated with oral surgery for each type of inherited bleeding disorder and to evaluate the efficacy of the treatment protocols set up in our tertiary care center.
MATERIALS AND METHODS: We included all patients with an inherited bleeding disorder, managed in our oral and maxillofacial surgery department with a treatment protocol set up by our local Haemophilia Treatment Centre for an oral surgical procedure.
RESULTS: Between January 2006 and December 2018, 295 treatment protocols were set up for the management of patients with haemorrhagic risk in oral surgical procedures. Of these, 203 were scheduled to take place in our department. A total of 180 oral surgical procedures for 147 patients were included. The incidence of bleeding complications in our study was 4.44% (8 out of 180) with a significantly higher risk in patients with haemophilia, the mean time to onset of bleeding was 11 days.
DISCUSSION: The use of a treatment protocol for the management of patients with inherited bleeding disorders in oral surgery seems effective. Our rate of bleeding complications was comparable to data in the literature, and often lower.
BibTeX:
@article{Landart2022b,
  author = {Landart, Cécile and Barbay, Virginie and Chamouni, Pierre and Trost, Olivier},
  title = {Management of patients with inherited bleeding disorders in oral surgery: {A} 13-year experience},
  month = {October},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2022},
  volume = {123},
  number = {5},
  pages = {e405--e410},
  doi = {10.1016/j.jormas.2022.02.003}
}

Abstract: The frequency of potential drug-drug interactions (DDI) in published studies on real world data considerably varies due to the methodological framework. Contextualization of DDI has a proven effect in limiting false positives. In this paper, we experimented with the application of various DDIs contexts elements to see their impact on the frequency of potential DDIs measured on the same set of prescription data collected in EDSaN, the clinical data warehouse of Rouen University Hospital. Depending on the context applied, the frequency of daily prescriptions with potential DDI ranged from 0.89% to 3.90%. Substance-level analysis accounted for 48% of false positives because it did not account for some drug-related attributes. Consideration of the patient's context could eliminate up to an additional 29% of false positives.
BibTeX:
@inproceedings{Lelong2022,
  author = {Lelong, Romain and Dahamna, Badisse and Berthelot, Hélène and Duville, Willy and Letord, Catherine and Grosjean, Julien and Duclos, Catherine},
  title = {When {Context} {Matters} for {Credible} {Measurement} of {Drug}-{Drug} {Interactions} {Based} on {Real}-{World} {Data}},
  booktitle = {Challenges of Trustable AI and Added-Value on Health (MIE2022)},
  month = {May},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {294},
  pages = {38--42},
  doi = {10.3233/SHTI220392}
}

Abstract: The Normandy health data warehouse EDSaN integrates the medication orders from the University Hospital of Rouen (France). This study aims at describing the design and the evaluation of an information retrieval system founded on a complex and semantically augmented knowledge graph dedicated to EDSaN drugs' prescriptions. The system is intended to help the selection of drugs in the search process by health professionals. The manual evaluation of the relevance of the returned drugs showed encouraging results as expected. A deeper analysis in order to improve the ranking method is needed and will be performed in a future work.
BibTeX:
@inproceedings{Lelong2021,
  author = {Lelong, Romain and Dahamna, Badisse and Leguillon, Romain and Grosjean, Julien and Letord, Catherine and Darmoni, Stéfan J. and Soualmia, Lina F.},
  title = {Assisting {Data} {Retrieval} with a {Drug} {Knowledge} {Graph}},
  month = {January},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {289},
  pages = {260--263},
  url = {https://www.cismef.org/cismef/wp/wp-content/uploads/2021/10/presentation.pdf},
  doi = {10.3233/SHTI210909}
}

Abstract: Teleconsultation has become a new means of using care which has taken off significantly since the COVID crisis, The pooling of the technological environment within the TC makes it possible to set up practice reviews by reusing the data collected. Our aim was to evaluate the relevance of antibiotic therapy during teleconsultations carried out on the national teleconsultation platform "Qare" in 4 common infections. 143,428 TCs with structured prescriptions were analyzed, with an appropriate prescription in more than 82% of cases, higher than in the literature. The use of data makes it possible to quickly assess practices and inform doctors to improve their practices.
BibTeX:
@article{Melot2022,
  author = {Melot, B. and Amsilli, M. and Drouet, F. and Rodriguez, L. and Salomon, J. and Grosjean, J. and Duclos, C.},
  title = {Appropriateness of {Antibiotic} {Prescription} {During} {Teleconsultation}},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {298},
  pages = {142--146},
  doi = {10.3233/SHTI220924}
}

Abstract: Polypharmacy in elderly is a public health problem with both clinical (increase of adverse drug events) and economic issues. One solution is medication review, a structured assessment of patients' drug orders by the pharmacist for optimizing the therapy. However, this task is tedious, cognitively complex and error-prone, and only a few clinical decision support systems have been proposed for supporting it. Existing systems are either rule-based systems implementing guidelines, or documentary systems presenting drug knowledge. In this paper, we present the ABiMed research project, and, through literature reviews and brainstorming, we identified five candidate innovations for a decision support system for medication review: patient data transfer from GP to pharmacists, use of semantic technologies, association of rule-based and documentary approaches, use of machine learning, and a two-way discussion between pharmacist and GP after the medication review.
BibTeX:
@inproceedings{mouazer:hal-03479318,
  author = {Mouazer, Abdelmalek and Leguillon, Romain and Leroy, Bertille and Sedki, Karima and Simon, Christian and Falcoff, Hector and Schuers, Matthieu and Dubois, Sophie and Bousquet, Cédric and Soualmia, Lina and Letord, Catherine and Darmoni, Stéfan and Bouaud, Jacques and Séroussi, Brigitte and Tsopra, Rosy and Lamy, Jean-Baptiste},
  title = {{ABiMed}: {Towards} an {Innovative} {Clinical} {Decision} {Support} {System} for {Medication} {Reviews} and {Polypharmacy} {Management}},
  month = {January},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {289},
  pages = {61--64},
  url = {https://hal.archives-ouvertes.fr/hal-03479318},
  doi = {10.3233/SHTI210859}
}

Abstract: Suitable causal inference in biostatistics can be best achieved by knowledge representation thanks to causal diagrams or directed acyclic graphs. However, necessary and sufficient causes are not easily represented. Since existing ontologies do not fill this gap, we designed OntoBioStat in order to enable covariate selection support based on causal relation representations. OntoBioStat automatic ontological causal diagram construction and inferences are detailed in this study. OntoBioStat inferences are allowed by Semantic Web Rule Language rules and axioms. First, statements made by the users include outcome, exposure, covariate, and causal relation specification. Then, reasoning enable automatic construction using generic instances of MetaVariable and NecessaryVariable classes. Finally, inferred classes highlighted potential bias such as confounder-like. Ontological causal diagram built with OntoBioStat was compared to a standard causal diagram (without OntoBioStat) in a theoretical study. It was found that confounding and bias were not completely identified by the standard causal diagram, and erroneous covariate sets were provided. Further research is needed in order to make OntoBioStat more usable.
BibTeX:
@article{PressatLaffouilhere2022,
  author = {Pressat Laffouilhère, Thibaut and Grosjean, Julien and Bénichou, Jacques and Darmoni, Stefan J. and Soualmia, Lina F.},
  title = {{OntoBioStat}: {Supporting} {Causal} {Diagram} {Design} and {Analysis}},
  month = {May},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {294},
  pages = {302--306},
  doi = {10.3233/SHTI220463}
}

Abstract: Understanding statistical results is crucial in order to spread right conclusions. In observational studies, statistical results are often reported as associations without going further. However, each association comes from causal relations. Causal diagrams are visual representations enabling to understand causal mechanisms behind the association found. In the era of big data and growing number of variables, visual approaches become inefficient. Ontological representation of causality and reasoning could help to explain statistical results. OntoBioStat is a domain ontology related to covariate selection and bias for biostatistician users. It was designed using expert corpus from comprehensive literature review, and validated by three biostatisticians accustomed to causal diagrams. In this paper, we focused on the presentation of an OntoBioStat’s feature able to infer explanations about statistical associations. The ontologization of the feature of interest resulted in 14 object properties, three classes and five Semantic Web Rule Language rules. Each rule allows to infer a different object-property that explains statistical association between two variables. Rules are based on isCauseof statements between different individuals. OntoBioStat feature performances were illustrated through a real-life retrospective observational study. From 28 instances and 48 object properties stated, a set of 1,939 object properties were inferred. OntoBioStat explained 65% of the 48 statistical associations found. In conclusion, OntoBioStat could help to explain a part of the significant statistical associations between two variables but cannot yet predict significant ones.
BibTeX:
@inproceedings{Pressat-Laffouilhere2022,
  author = {Pressat Laffouilhère, Thibaut and Grosjean, Julien and Pinson, Jean and Darmoni, Stéfan J. and Leveque, Emilie and Lanoy, Emilie and Bénichou, Jacques and Soualmia, Lina F.},
  title = {Ontological {Representation} of {Causal} {Relations} for a {Deep} {Understanding} of {Associations} {Between} {Variables} in {Epidemiology}},
  booktitle = {Artificial {Intelligence} in {Medicine}},
  address = {Cham},
  publisher = {Springer International Publishing},
  year = {2022},
  series = {Lecture {Notes} in {Computer} {Science}},
  pages = {47--56},
  doi = {10.1007/978-3-031-09342-5_5}
}

Abstract: BACKGROUND: Although the drug is finished, identifiable, there is no universally accepted standard for naming them. The objective of this work is to evaluate qualitatively the HeTOP drug terminology server by two categories of students: (a) pharmacy students and (b) a control group.
METHODS: A formal evaluation was built to measure the perception of users about the HeTOP drug server, using the three mains questions about "teaching interest", "skill interest" (or competence) and "ergonomics".
RESULTS: The three pharmacy student subgroups gave the best and the worst score to the same categories.
CONCLUSION: All three criteria are rated above 6.5 out of 10. The HeTOP drug terminology server is freely available to "non drug" specialists (URL: www.hetop.eu/hetop/drugs/).
BibTeX:
@inproceedings{Zana2022,
  author = {Zana, Ilan and Grosjean, Julien and Letord, Catherine and Charlet, Jean and Rio, Julien and Darmoni, Elaï T. N. and Duclos, Catherine and Darmoni, Stéfan J.},
  title = {Qualitative {Evaluation} of a {Drug} {Terminology} {Server}},
  booktitle = {MEDINFO 2021: One World, One Health – Global Partnership for Digital Innovation},
  month = {June},
  journal = {Studies in Health Technology and Informatics},
  year = {2022},
  volume = {290},
  pages = {1002--1003},
  doi = {10.3233/SHTI220238}
}

Abstract: Introduction
L’enthésite est une atteinte caractéristique des spondyloarthrites souvent réfractaire aux traitements usuels locaux (physiothérapie, infiltrations, ondes de choc radiales (ODC)) et systémiques (AINS, DMARDs synthétiques et biologiques). Les options thérapeutiques des enthésites rebelles sont limitées [1]. Dans ce cadre, le traitement par laser C02 pourrait avoir un intérêt. L’objectif était l’évaluation de l’efficacité et de la tolérance d’un protocole laser C02 dans le cadre d’enthésites rebelles aux traitements usuels évoluant dans le cadre d’une spondyloarthrite (SpA) ou d’un rhumatisme psoriasique (RP).
Patients et méthodes
Cette étude monocentrique menée en soins courants avec suivi standardisé a inclus tous les patients âgés de 18 ans ou plus, atteints de SpA ou RP répondant respectivement aux critères ASAS et CASPAR et présentant des enthésites rebelles à plusieurs traitements systémiques et locauxcomme définis précédemment). Les enthésites devaient avoir été authentifiées par IRM (œdème osseux adjacent à l’insertion d’un tendon) et/ou échographie (remaniement/érosion de l’enthèse à l’échographie, doppler textless 4mm de l’enthèse, présence d’une bursite). Chaque patient a bénéficié d’un protocole laser C02 de 8 séances. Il a été recueilli de façon standardisée à la première séance (S1), 8e séance (S8) et un mois après la fin du protocole (M1) la présence/absence de réveils nocturnes (RN), la présence ou non d’un dérouillage matinal (DM), l’EVA douleur au repos, l’EVA douleur à l’effort, le BASDAI avec focus sur l’item 4 (enthésites) et le pourcentage d’amélioration déclaré par le patient avec différents seuils : très satisfait (amélioration de 80 , satisfait (amélioration comprise entre 50 et 79 , modérément satisfait (amélioration entre 30 et 49 , insatisfait (textless 30 . Le recueil a été effectué à l’aide de l’EDSaN, l’Entrepôt de données de santé du CHU de Rouen [2].
Résultats
Cinq patients (2 SpA et 3 RP) ont bénéficié d’un protocole laser C02 pour des enthésites rebelles aux traitements usuels. Les localisations traitées étaient le moyen glutéal (3 patients) et le tendon d’achille (2 patients). Deux patients étaient sous DMARDs synthétiques (méthotrexate et léflunomide), un sous anti-IL17, un autre sous anti-TNFa et le dernier sous AINS seuls. Tous ont bénéficié de kinésithérapie ± ODC. Trois patients ont eu des infiltrations préalables. La durée d’évolution moyenne des symptômes était de 25 mois. Quatre patients sur cinq présentaient un DM et des RN en lien avec le site de l’enthésite à S1 et S8. Le DM et les RN ont disparu chez 2 patients à M1. La moyenne des BASDAI a diminué au cours du protocole passant de 5,1 à S1 à 3,34 à M1. La moyenne de l’item 4 du BASDAI a également diminué passant de 8 à S1, à 4,2 à S8 et 4 à M1. La moyenne des EVA douleur repos n’a pas significativement changé durant le protocole (entre 1 et 2/10). Celle des EVA douleur effort a nettement diminué passant de 7,5 à S1, à 2,6 à S8 et 3,2 à M1. Enfin, 4 patients sur 5 ont déclaré une amélioration au cours du protocole avec 3 patients très satisfaits, un patient satisfait, et le dernier insatisfait. Un seul patient n’a pas présenté du tout d’amélioration de la symptomatologie. Ceci peut s’expliquer par l’existence d’une fissure du tendon d’Achille visualisée à l’IRM et à l’échographie. Il n’a pas été observé d’effet indésirable imputable au protocole laser chez les 5 patients.
Conclusion
Dans cette série de 5 cas, le laser C02 paraît une option prometteuse dans le traitement des enthésites réfractaires dans le cadre des SpA avec ou sans psoriasis.
BibTeX:
@article{Brevet2022,
  author = {Brevet, P. and Roudesli, M. and Protat, P. and Patenere, C. and Michaud, J. and Grosjean, J. and Lequerré, T. and Vittecoq, O.},
  title = {Enthésites résistantes dans la spondyloarthrite et le rhumatisme psoriasique traitées par laser {C02} : résultats d’une étude pilote},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2022},
  series = {35e {Congrès} {Français} de {Rhumatologie}},
  volume = {89},
  pages = {A158--A159},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833022004367},
  doi = {10.1016/j.rhum.2022.10.236}
}

Abstract: Introduction
Les spondylodiscites infectieuses (SPI) sont des infections du disque intervertébral et des vertèbres adjacentes potentiellement sévères, en particulier du fait d’un risque de complications neurologiques déficitaires survenant dans environ 9,2 % selon l’étude SPONDIMMO [1]. Seules deux études françaises ont étudié les facteurs de risque d’atteinte déficitaire qui sont : la présence d’un abcès épidural, une atteinte cervicale ou thoracique, une CRPtextgreater150mg/L et une SPI à S. aureus [2]. L’objectif de cette étude monocentrique, rétrospective, était de décrire les caractéristiques des patients présentant une SPI déficitaire et de déterminer les facteurs associés à la survenue d’un tel déficit.
Patients et méthodes
À l’aide de l’entrepôt de données de santé, ont été recueillies toutes les suspicions de spondylodiscite hospitalisées dans un service de médecine ou de chirurgie de 2010 à 2020. Après révision des dossiers et exclusion des diagnostics différentiels, les patients déficitaires (présentant des troubles sphinctériens ou un déficit moteurtextless4/5) ont été comparés avec le reste de la cohorte. L’analyse statistique a été faite par test exact de Fisher pour les données qualitatives et par test de Mann-Whitney pour les données quantitatives. Les variables significativement différentes en analyse univariée ont ensuite été intégrées dans un modèle de régression logistique pour analyse multivariée.
Résultats
Après analyse de 821 dossiers, 329 patients ont été inclus. L’âge moyen était de 67,2 ans, il y avait 61,1 % d’hommes. L’atteinte rachidienne était lombaire pour 238 patients (72,3  et multifocale pour 59 (17,9 . Les bactéries causales étaient : Staphylococcus sp. pour 127 (38,6  patients Streptococcus ou Enterococcus sp. pour 88 (26,7 , bacille gram négatif (BGN) pour 45 (13,7  et mycobactérie pour 14 (4,3 . Quarante-neuf (14,9  patients présentaient une atteinte neurologique sévère dans cette cohorte, 26 étaient déficitaires d’emblée, tandis que 23 le sont devenu en cours d’hospitalisation. Après analyse multivariée, les variables associées à un déficit neurologique étaient : une infection à mycobactérie (OR 8,7 [2,2–34,4]), une infection à BGN (OR 3,0 [1,2–7,3]) la présence d’une épidurite (OR 5,4 [2,5–11,8]), une atteinte cervicale ou dorsale (OR 2,1 [1,0–4,4]) et une CRPtextgreater50mg/L (OR 5,4 [1,1–26,7]). La découverte de la SPI dans un contexte de sepsis pré-existant était associée à l’absence de déficit OR (0,3 [0,1–0,8]). L’analyse des variables associées à la survenue d’un déficit neurologique au cours de l’hospitalisation était : une infection à mycobactérie (OR 11,0 [2,6–45,5]), une infection à BGN (OR 3,2 [1,1–9,7]) et la présence d’une épidurite à l’imagerie (OR 3,8 [1,4–10,5]). Vingt (40  patients ont été traités par décompression chirurgicale avec une récupération motrice pour 13 (65 , 29 (60  ont été traités médicalement avec une récupération motrice pour 18 (62 .
Conclusion
Il s’agit, à notre connaissance, de la première étude identifiant les SPI à mycobactérie et BGN comme à risque significatif d’atteinte neurologique sévère.
BibTeX:
@article{Desvaux2022,
  author = {Desvaux, M. and Gravière, A. and Grosjean, J. and Fiaux, E. and Rasoldier, V. and Étienne, M. and Ould-Slimane, M. and Cantogrel, P. and Curey-Levêque, S. and Lozouet, M. and Pouplin, S. and Lequerré, T. and Vittecoq, O. and Avenel, G.},
  title = {Étude des facteurs associés à un risque d’atteinte neurologique sévère dans les spondylodiscites infectieuses dans une cohorte de 329 cas},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2022},
  series = {35e {Congrès} {Français} de {Rhumatologie}},
  volume = {89},
  pages = {A47},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833022002563},
  doi = {10.1016/j.rhum.2022.10.056}
}

Abstract: Introduction
Devant une image de spondylodiscite (SD) sur l’imagerie, la SD infectieuse est l’étiologie la plus redoutée. L’enquête bactériologique n’est pas concluante dans environ 30 % des cas [1]. Au cours de ces dernières années, plusieurs étiologies de SD non infectieuses ont été décrites : inflammatoire, microcristalline, dégénérative. Notre travail consistait, à partir d’une population de SD suspectées à l’imagerie, à comparer les SD dont l’étiologie infectieuse était prouvée par une documentation bactériologique aux SD non documentées.
Patients et méthodes
À l’aide de l’entrepôt de données de santé, ont été recueillies toutes les suspicions de spondylodiscite hospitalisées dans un service de médecine ou de chirurgie de 2010 à 2020. L’analyse statistique a été faite par test exact de Fisher pour les données qualitatives et par test de Mann-Whitney pour les données quantitatives.
Résultats
Après analyse des 821 dossiers, 329 ont été inclus. Deux cent soixante-quinze SD (84  étaient documentées, dont 209 (75  par hémoculture et 68 (25  par une ponction-biopsie disco-vertébrale (PBDV). Cinquante-quatre (16  n’étaient pas documentées. Les SDI documentées (n = 275) étaient plus souvent fébriles (58,9 % vs 40,7 % chez les non documentées, p = 0,016), avaient un syndrome inflammatoire biologique plus important (CRP maximale à 187 ± 122mg/L vs 114 ± 109mg/L, p textless 0,0001), et étaient plus récentes (évolutiontextless1 mois pour 193 (70  vs 25 (46  pour les SD non documentées). L’analyse du sous-groupe de SD à hémoculture négative et qui ont du bénéficier d’une PBDV ne montrait pas de différence entre les SD documentées et non documentées. Parmi les 54 spondylodiscites non documentées, 37 ont reçu une antibiothérapie probabiliste, dont la majorité consistait en une association fluoroquinolone et rifampicine. Quinze patients n’ont pas reçu d’antibiotique, à 1 mois, le scanner montrait une stabilité des lésions, le taux CRP était normal et aucune complication n’était survenue. Deux patients ont été perdus de vue et l’évolution n’a pu être analysée. Parmi SD non documentées et non traitées, le diagnostic finalement retenu était majoritairement celui de discopathie dégénérative (7/15).
Conclusion
Dans cette cohorte, 16 % des SD n’étaient pas documentées. Les différences observées étaient surtout le fait des spondylodiscites très inflammatoires documentées par hémoculture. Aucune différence significative n’était mise en évidence entre la population des SD documentées et non documentées permettant de soutenir l’hypothèse d’une origine non bactérienne dans cette situation.
BibTeX:
@article{Graviere2022,
  author = {Gravière, A. and Desvaux, M. and Grosjean, J. and Fiaux, E. and Rasoldier, V. and Étienne, M. and Pouplin, S. and Lequerré, T. and Vittecoq, O. and Avenel, G.},
  title = {Analyse descriptive des spondylodiscites sans documentation bactériologique issues d’une cohorte de 329 spondylodiscites suspectées d’être infectieuses à l’imagerie},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2022},
  series = {35e {Congrès} {Français} de {Rhumatologie}},
  volume = {89},
  pages = {A47--A48},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833022002575},
  doi = {10.1016/j.rhum.2022.10.057}
}

Abstract: Introduction
L’omalizumab (OMA), anticorps monoclonal anti-IgE, peut être prescrit depuis 2015 en France dans les urticaires chroniques spontanées (UCS) résistantes aux antihistaminiques. Une rémission spontanée est possible et il n’existe pas de recommandation sur la durée optimale de traitement par OMA. Notre objectif était d’évaluer les modalités d’arrêt de l’OMA en vie réelle dans une cohorte multicentrique française.
Matériel et méthodes
Nous avons réalisé une étude observationnelle, rétrospective, dans 9 centres français affiliés au Groupe Urticaire de la SFD, incluant tous les patients ayant une UCS et/ou inductible (UCInd) traités par au moins une injection d’OMA entre janvier 2009 et janvier 2021 afin d’analyser la survie du traitement par OMA. La réponse au traitement par OMA a été évaluée 6 mois après le début du traitement en utilisant les scores PGA, UCT et UAS7 et leurs seuils habituels (réponse complète ou quasi-complète si UCTtextgreater12 et/ou UAS7textless6 et/ou PGA 0 ou 1). La réponse était considérée comme rapide si complète avant 3 mois d’OMA. La réponse aux traitements antérieurs à l’OMA était évaluée en utilisant les mêmes scores recueillis à des moments variables en raison du caractère rétrospectif de l’étude.
Résultats
Au total, 878 patients ont été inclus, avec une efficacité et tolérance de l’OMA semblables à la littérature. La réponse initiale était davantage complète et rapide chez les patients ayant une UCS versus UCInd (65,4 % vs 56,3 % respectivement) et en l’absence de comorbidité auto-immune (64,4 % vs 51,6 . Au total, 408 patients (46,5  ont arrêté l’OMA au cours du suivi et 198 de ces patients l’ont repris après 7,7 mois en moyenne avec une efficacité retrouvée. Après 1 an de suivi, 66 % des patients n’avaient encore jamais interrompu l’OMA. Les raisons d’arrêt de l’OMA étaient : l’obtention d’un bon contrôle de l’urticaire (n=203, 23,1 , l’inefficacité de l’OMA (n=88, 10 , la survenue d’une contre-indication (n=44, 5 , des motifs personnels (n=35, 4 , des effets indésirables (n=23, 2,6 , ou inconnues (n=15, 1,8 . Les patients atopiques et ceux ayant eu des thérapeutiques antérieures autres que les antihistaminiques (et hors AMM, telles que l’hydroxychloroquine) étaient ceux qui arrêtaient l’OMA le plus précocement pour bon contrôle de l’urticaire. En revanche, les patients ayant une UCInd et ceux ayant une comorbidité auto-immune arrêtaient l’OMA de façon plus précoce pour inefficacité, effets indésirables, survenue d’une contre-indication ou pour motifs personnels. Les femmes arrêtaient plus précocement l’OMA que les hommes pour apparition d’une contre-indication (telle qu’une grossesse). Chez l’ensemble des patients, une durée plus longue de l’urticaire était associée à un traitement plus prolongé par OMA.
Discussion
Les facteurs qui semblent avoir influencé la survie du traitement par OMA dans cette étude reflètent probablement des différences de réponse à l’OMA entre certaines sous-populations d’urticariens chroniques, comme déjà décrit dans la littérature sur de plus faibles effectifs : les patients atopiques semblaient meilleurs répondeurs que ceux ayant une comorbidité auto-immune ou une UCInd. Des études prospectives comparant et évaluant différentes modalités d’arrêt de l’OMA après obtention d’un bon contrôle de l’urticaire sont nécessaires afin d’optimiser la prise en charge individuelle.
BibTeX:
@article{Litovsky2022,
  author = {Litovsky, J. and Paryl, M. and Hacard, F. and Tétart, F. and Boccon Gibod, I. and Dezoteux, F. and Staumont-Sallé, D. and Darrigade, A. S. and Doutre, M. S. and Milpied, B. and Soria, A. and Amsler, E. and Bernier, C. and Perrot, J. L. and Raison Peyron, N. and Mura, T. and Grosjean, J. and Du Thanh, A.},
  title = {Étude de survie du traitement par omalizumab dans une cohorte multicentrique française de patients atteints d’urticaire chronique},
  month = {November},
  journal = {Annales de Dermatologie et de Vénéréologie - FMC},
  year = {2022},
  series = {Journées dermatologiques de {Paris}, 29 novembre - 3 décembre 2022},
  volume = {2},
  number = {8, Supplement 1},
  pages = {A65},
  url = {https://www.sciencedirect.com/science/article/pii/S2667062322003373},
  doi = {10.1016/j.fander.2022.09.063}
}

BibTeX:
@inproceedings{2022,
  author = {Marc Jamoulle},
  title = {Post-acute sequelae of SARS-CoV-2 infection or Long Covid},
  booktitle = {WICC annual meeting},
  year = {2022},
  url = {https://orbi.uliege.be/bitstream/2268/294818/1/_Post-acute%20sequelae%20of%20SARS-CoV-2%20infection.pdf}
}

BibTeX:
@inproceedings{Jamoulle2022,
  author = {Marc Jamoulle},
  title = {Somes issues in the field of classification and terminology. Notes about ICPC-3},
  booktitle = {WICC annual meeting},
  year = {2022},
  url = {https://orbi.uliege.be/bitstream/2268/294821/1/WICC%20Copenhagen.pdf}
}

BibTeX:
@inproceedings{Leguillon2022,
  author = {Romain Léguillon and Laura Gosselin and Christophe Carnoy and Thibaut Pressat-Laffouilhère and Catherine Letord and Badisse Dahamna and Stéfan Darmoni and Julien Gr},
  title = {A new knowledge organisation for monoclonal antibodies use authorised in Europe: a multi-terminology thesaurus to facilitate queries within clinical data warehouses},
  booktitle = {JNRB 2022 Journée Normandie de recherche biomédicale},
  year = {2022}
}

Abstract: Contexte : cet article présente une recherche financée par l’Agence Nationale de la Recherche (ANR) sur la conception d’une aide à la décision de prescription d’applications mobiles de santé pour les médecins généralistes français. Objectif et méthode : Cette recherche, proposée par un consortium interuniversitaire, est devenue, en cours d’élaboration, interdisciplinaire en partenariat avec les patients. L’article éclaire tant les phases constituées mobilisant à tour de rôle les différents chercheurs, professionnels, citoyens et patients, les modalités de partenariat initiés, que les résultats de la recherche. Conclusion : Parmi la pléthore d’applications mobiles en santé mises sur le marché, un processus d’évaluation critique a été conçu permettant une aide à la décision de prescription d’application mobile. La méthodologie mobilisée participe à une approche participative de tous les acteurs du Soin dont les patients font aujourd’hui partie, une manière d’appréhender la complexité qui permet de relever les défis d’adhésion du plus grand nombre.
BibTeX:
@article{Flora2022,
  author = {Flora, Luigi and Darmon, David and Darmoni, Stefen Sd and Julien, Grosjean and Simon, Christian and Hassanaly, Parina and Dufour, Jean-Charles},
  title = {Innover en partenariat par la création d'une aide à la décision d'application mobiles dans la relation médecin-patient : {La} recherche {ApiAppS}},
  journal = {La revue sur le partenariat de soin avec le patient : analyses},
  year = {2022},
  number = {4},
  pages = {73},
  url = {https://hal.science/hal-03717896}
}

Abstract: Avec l'adoption généralisée des dossiers médicaux électroniques (DME), des quantités de plus en plus importantes de données cliniques électroniques sont générées, ce qui fait que les chercheurs, les administrateurs de soins de santé et les cliniciens s'intéressent de plus en plus à l'utilisation de telles données. Le projet EDSaNCoh, sélectionné et financé par le FEDER (Fonds européen de développement régional), vise à développer une plateforme pour créer et alimenter automatiquement des e-cohortes prospectives. L'objectif final du projet est d'optimiser la recherche non interventionnelle sur les données épidémiologiques et cliniques en réduisant les erreurs humaines, la charge de travail, la complexité de la saisie des données et le temps consacré à la collecte des données par rapport aux méthodes de recherche actuelles, ce qui se traduit finalement par une réduction des coûts. Le premier projet tirant parti de l'infrastructure EDSaNCoh est EDILS2.0 (Eating Disorders Inventory Longitudinal Study) dont l'objectif principal est d'identifier, 2 et 5 ans après une première consultation pour Trouble du Comportement Alimentaire (TCA), les facteurs pronostiques de guérison, de rémission, de changement de type de trouble alimentaire et de décès ou suicide. METHODOLOGIE : Trois sont les sources de données combinées par l'infrastructure EDSaNCoh : l'entrepôt de données de santé du CHU de Rouen, le SNDS (système national des données de santé), et des questionnaires auto-administrables directement envoyés aux patients. Afin d'évaluer les capacités de l'algorithme construit pour EDILS2.0 à identifier correctement les patients répondant aux critères d'inclusion et à récupérer correctement les variables ciblées, ses performances ont été comparées automatiquement, sur un ensemble de documents aléatoires, à un gold standard humain. textlessbrtextgreaterRESULTATS : textlessbrtextgreaterL'algorithme a donné de bons résultats, atteignant 96 % de précision et 88,1 % de recall pour l'inclusion des patients. En ce qui concerne ses capacités d'extraction de caractéristiques, il a obtenu, sur un ensemble de 24 variables, une accuracy moyenne de 94,08%. CONCLUSION : Selon les résultats préliminaires, EDILS2.0 montre une qualité de données très prometteuse, une qualité qui est, je crois, encore améliorable. Les optimisations suggérées sont de nature conservatrice, elles sont faciles à mettre en œuvre et ne nécessitent pas d'adaptations des pratiques de travail, ce qui devrait se traduire par une mise en œuvre sans friction. En cas de succès, elles feront passer la précision de l'algorithme d'extraction des caractéristiques dans une "zone de confiance", au-delà de la barre des 95 ce qui est crucial pour la fiabilité des analyses futures. Tel résultat servira également de manifeste des bons résultats que l'on peut obtenir avec les e-cohortes et de la qualité du projet EDSaNCoh et favorisera l'intérêt pour cette technologie.
BibTeX:
@phdthesis{Monti2022,
  author = {Monti, Francesco},
  title = {{EDSaNCoh} et {EDILS2}.0 : résultats préliminaires et perspectives},
  month = {October},
  school = {Université de Rouen Normandie},
  year = {2022},
  note = {Pages: 49},
  url = {https://dumas.ccsd.cnrs.fr/dumas-03858400}
}

2021


BibTeX:
@article{Deroualle2021,
  author = {Deroualle, Tiffany and Dominique, Stéphane and Monti, Francesco and Grosjean, Julien and Darmoni, Stéfan and Lequerré, Thierry and Vittecoq, Olivier},
  title = {Rheumatologic manifestations of sarcoidosis and increased risk of spondyloarthritis occurrence. {A} retrospective single center case-control study},
  month = {December},
  journal = {Joint Bone Spine},
  year = {2021},
  volume = {88},
  number = {6},
  pages = {105247},
  doi = {10.1016/j.jbspin.2021.105247}
}

Abstract: BACKGROUND:
PubMed is one of the most important basic tools to access medical literature. Semantic query expansion using synonyms can improve retrieval efficacy.
OBJECTIVE:
The objective was to evaluate the performance of three semantic query expansion strategies.
METHODS:
Queries were built for forty MeSH descriptors using three semantic expansion strategies (MeSH synonyms, UMLS mappings, and mappings created by the CISMeF team), then sent to PubMed. To evaluate expansion performances for each query, the first twenty citations were selected, and their relevance were judged by three independent evaluators based on the title and abstract.
RESULTS:
Queries built with the UMLS expansion provided new citations with a slightly higher mean precision (74.19%) than with the CISMeF expansion (70.28%), although the difference was not significant. Inter-rater agreement was 0.28. Results varied greatly depending on the descriptor selected.
DISCUSSION:
The number of citations retrieved by the three strategies and their precision varied greatly according to the descriptor. This heterogeneity could be explained by the quality of the synonyms. Optimal use of these different expansions would be through various combinations of UMLS and CISMeF intersections or unions.
CONCLUSION:
Information retrieval tools should propose different semantic expansions depending on the descriptor and the search objectives.
BibTeX:
@article{Massonaud2019,
  author = {Clément Massonaud and Romain Lelong and Gaétan Kerdelhué and Emeline Lejeune and Julien Grosjean and Nicolas Griffon and Stéfan Darmoni},
  title = {Performance evaluation of three semantic expansions to query {PubMed}},
  journal = {Health Information and Libraries Journal},
  year = {2021},
  volume = {38},
  number = {2},
  pages = {113-124},
  doi = {10.1111/hir.12291}
}

Abstract: OBJECTIVES: To introduce the 2021 International Medical Informatics Association (IMIA) Yearbook by the editors.
METHODS: The editorial provides an introduction and overview to the 2021 IMIA Yearbook whose special topic is "Managing Pandemics with Health Informatics - Successes and Challenges". The Special Topic, the keynote paper, and survey papers are discussed. The IMIA President's statement and the IMIA dialogue with the World Health Organization are introduced. The sections' changes in the Yearbook Editorial Committee are also described.
RESULTS: Health informatics, in the context of a global pandemic, led to the development of ways to collect, standardize, disseminate and reuse data worldwide: public health data but also information from social networks and scientific literature. Fact checking methods were mostly based on artificial intelligence and natural language processing. The pandemic also introduced new challenges for telehealth support in times of critical response. Next generation sequencing in bioinformatics helped in decoding the sequence of the virus and the development of messenger ribonucleic acid (mRNA) vaccines.
CONCLUSIONS: The Corona Virus Disease 2019 (COVID-19) pandemic shows the need for timely, reliable, open, and globally available information to support decision making and efficiently control outbreaks. Applying Findable, Accessible, Interoperable, and Reusable (FAIR) requirements for data is a key success factor while challenging ethical issues have to be considered.
BibTeX:
@article{Soualmia2021,
  author = {Soualmia, Lina F. and Hollis, Kate Fultz and Mougin, Fleur and Séroussi, Brigitte},
  title = {Health {Data}, {Information}, and {Knowledge} {Sharing} for {Addressing} the {COVID}-19},
  month = {August},
  journal = {Yearbook of Medical Informatics},
  year = {2021},
  volume = {30},
  number = {1},
  pages = {4--7},
  doi = {10.1055/s-0041-1726541}
}

Abstract: BACKGROUND: The roll-out of COVID-19 vaccines is a multi-faceted challenge whose performance depends on pace of vaccination, vaccine characteristics and heterogeneities in individual risks.
METHODS: We developed a mathematical model accounting for the risk of severe disease by age and comorbidity, and transmission dynamics. We compared vaccine prioritisation strategies in the early roll-out stage and quantified the extent to which measures could be relaxed as a function of the vaccine coverage achieved in France.
FINDINGS: Prioritizing at-risk individuals reduces morbi-mortality the most if vaccines only reduce severity, but is of less importance if vaccines also substantially reduce infectivity or susceptibility. Age is the most important factor to consider for prioritization; additionally accounting for comorbidities increases the performance of the campaign in a context of scarce resources. Vaccinating 90% of ≥65 y.o. and 70% of 18-64 y.o. before autumn 2021 with a vaccine that reduces severity by 90% and susceptibility by 80 we find that control measures reducing transmission rates by 15-27% should be maintained to remain below 1000 daily hospital admissions in France with a highly transmissible variant (basic reproduction number R0  = 4). Assuming 90% of ≥65 y.o. are vaccinated, full relaxation of control measures might be achieved with a vaccine coverage of 89-100% in 18-64 y.o or 60-69% of 0-64 y.o.
INTERPRETATION: Age and comorbidity-based vaccine prioritization strategies could reduce the burden of the disease. Very high vaccination coverage may be required to completely relax control measures. Vaccination of children, if possible, could lower coverage targets necessary to achieve this objective.
BibTeX:
@article{TranKiem2021,
  author = {Tran Kiem, Cécile and Massonnaud, Clément R. and Levy-Bruhl, Daniel and Poletto, Chiara and Colizza, Vittoria and Bosetti, Paolo and Fontanet, Arnaud and Gabet, Amélie and Olié, Valérie and Zanetti, Laura and Boëlle, Pierre-Yves and Crépey, Pascal and Cauchemez, Simon},
  title = {A modelling study investigating short and medium-term challenges for {COVID}-19 vaccination: {From} prioritisation to the relaxation of measures},
  month = {August},
  journal = {EClinicalMedicine},
  year = {2021},
  volume = {38},
  pages = {101001},
  doi = {10.1016/j.eclinm.2021.101001}
}

Abstract: INTRODUCTION: A fire at the Lubrizol chemical factory in Rouen on September 26, 2019 generated a huge column of smoke directed northeast toward the city. As the eye might be particularly affected by the smoke and other toxic emissions from the fire, we assessed the impact of this industrial and ecological disaster on irritative eye surface disease in the week following the accident.
MATERIALS AND METHODS: We retrospectively collected the medical data of the patients who presented to the Ophthalmology Emergency Department (OED) of Rouen University Hospital (the only OED open during the days following the accident) during the week following the fire (W1). We compared these data with those of patients who presented during the week before the fire (W-1). We also collected data on patients presenting to the ED in general during W-1 and W1, including the number of visits directly related to the fire.
RESULTS: 361 patients presented to the OED during W1 following the fire, compared with 384 in W-1. Of these patients, 83 (23 had ocular surface disease in W1, versus 76 (20 in W-1. Conjunctivitis was found in 54 patients in W1 (39 viral, 9 allergic, 6 undetermined) versus 44 in W-1 (27 viral, 12 allergic, 5 undetermined). A dry irritative syndrome was present in 29 patients in W1 versus 32 in W-1. Only 4 patients directly attributed their symptoms to the fire: 2 viral conjunctivitis, 1 allergic conjunctivitis and 1 worried patient (at D2, D5, D7 and D7 following the fire respectively).
DISCUSSION: The number of emergency eye consultations did not change in the week following the Lubrizol factory fire (except for a decrease the day of the accident, related to the lock-down). There was a higher number of consultations in W1 for conjunctivitis, mostly viral in appearance and probably not directly related to the fire. The number of consultations for dry irritative syndrome was comparable between the two periods. Despite major media coverage of the event at the national level and a very high level of concern among the population, the fire does not seem to have had an effect on OED activity at Rouen University Hospital, nor on general ED visits. The stay-at-home order on the first day may have had a protective effect, avoiding direct exposure to smoke. The long-term consequences of the soot deposits on the ground as the smoke cloud passed over remain undetermined and are under surveillance. A review of the literature on the ocular consequences of industrial accidents is presented.
CONCLUSION: The Ophthalmology Emergency Department did not record increased activity in the week following the Lubrizol Rouen fire, and ocular surface disease did not give rise to more consultations than the week before the fire. This suggests that there was no or minimal immediate ocular toxicity of the smoke from the fire.
BibTeX:
@article{huard_impact_2021,
  author = {Huard, J. and Gueudry, J. and Leroy, J.-P. and Joly, L.-M. and Muraine, M.},
  title = {Impact de l’incendie de l’usine {Lubrizol} à {Rouen} le 26 septembre 2019 sur la fréquentation des urgences ophtalmologiques},
  month = {October},
  journal = {Journal Francais D'ophtalmologie},
  year = {2021},
  volume = {44},
  number = {8},
  pages = {1121--1128},
  doi = {10.1016/j.jfo.2020.07.022}
}

Abstract: Résumé
Introduction
Plusieurs bases de données existent dans le domaine de la santé au travail et le Plan National Santé Travail en a demandé une cartographie. Quatre d’entre elles sont analysées du point de vue de leur complémentarité et intersection. Sumer explore les expositions aux risques professionnels via l’expertise du médecin du travail. Evrest étudie les conditions de travail du point de vue des salariés ainsi que leur santé. MCP recense les pathologies en lien avec le travail et les expositions suspectées d’en être à l’origine. RNV3P identifie des associations entre expositions et pathologie via la cotation d’une imputabilité sur des critères scientifiques et non médico-légaux.
Objectif
Montrer la complémentarité de ces dispositifs à partir d’un exemple sur les femmes aides à domicile (FAAD).
Méthode
Au sein de chaque dispositif, les FAAD et les autres femmes ont été comparées. Puis, les résultats des 4 dispositifs ont été comparés entre eux.
Résultats
Les effectifs étaient de 425, 10 852, 797, 463 FAAD et 10 966, 263 384, 26 245, 11 253 autres femmes respectivement pour Evrest, MCP, RNV3P et Sumer. Par comparaison avec les autres femmes, les FAAD sont significativement plus âgées, plus souvent à temps partiel, exposées à des contraintes physiques ou biomécaniques, présentent plus souvent des affections de l’appareil locomoteur mais pas plus fréquemment de souffrance psychique. Enfin, le RNV3P enregistre des pathologies cutanées ou respiratoires alors qu’elles sont peu rapportées dans MCP.
Discussion
Chaque dispositif apporte des informations en lui-même mais le rapprochement des résultats des dispositifs, même s’ils n’explorent pas strictement les mêmes populations, apporte des informations complémentaires sur les différences de points de vue concernant les expositions entre salariés et professionnels de santé, les problèmes de santé des salariés liés ou non au travail, et les phénomènes conduisant à une sous déclaration en maladie professionnelle…
Summary
Introduction
Different health and work databases exist in France and the Occupational Health National Plan 2016-2020 asked to map them. Complementarity and intersection were studied for four of them. Sumer studies occupational expositions using occupational health practitioner expertise. Evrest studies working conditions perceived by workers and health, independently of his link with work. MCP studies pathologies caused by work and describes suspected link with exposures. RNV3P describes associations between exposures and pathologies and establishes an imputability degree, using scientific criterias and not medico-legal criteria.
Aim
The aim of this article is to show complementarity of 4 systems (Sumer, Evrest, MCP, RNV3P), using the example of a study describing women home help workers (WHWW).
Methods
In each system, WHHW were compared with other women workers. Then, results from each system were compared.
Results
Population was composed by 425, 10,852, 797, 463 WHHW and 10,966, 263,384, 26,245, 11,253 other women workers for Evrest, MCP, RNV3P et Sumer databases, respectively. By comparison with other women workers, WHHW were significantly older, working part-time, exposed to occupational physical and biomechanical constraints and had more often musculo-skeletal affections, but mental affections were not more frequent. RNV3P recorded cutaneous and respiratory pathologies whereas MCP did not.
Discussion
Bring together, the 4 systems give more information even if they don’t study same populations: for example, about different points of view of workers and occupational health professionals, about health problems differences when studying pathologies in general in workers or occupational diseases, about occupational pathology declaration to the social health system…
BibTeX:
@article{Rollin2021,
  author = {Rollin, L. and Andujar, P. and Bloch, J. and Chatelot, J. and Coutrot, T. and Dewitte, J. D. and Homere, J. and Léonard, M. and Leroyer, A. and Memmi, S. and Nisse, C. and Rosankis, E. and Tone, F. and Vongmany, N.},
  title = {Quelle complémentarité pour les dispositifs en santé travail ({Evrest}, {MCP}, {Sumer}, {RNV3P}) : un exemple à partir des métiers de l’aide à domicile chez les femmes ?},
  month = {May},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2021},
  volume = {82},
  number = {3},
  pages = {261--276},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878520311115},
  doi = {10.1016/j.admp.2020.11.002}
}

Abstract: Résumé
Objectifs
L’état de la démographie médicale en France a été globalement à la baisse depuis plusieurs années. Afin de limiter la baisse des effectifs de médecin du travail, le statut de collaborateur médecin a été créé. Notre but est d’évaluer le ressenti des conditions de travail des collaborateurs médecins et de le comparer à celui des internes de médecine et santé au travail.
Méthodes
Un questionnaire destiné à effectuer une enquête transversale a été utilisé. Le questionnaire a été administré à la population d’intérêt via LimeSurvey. Quatre universités du Nord-Ouest de la France où les inscriptions au DIU et au DES sont possibles ont été invitées à contribuer à notre étude.
Resultats
Les médecins du travail anciens internes le meilleur ressenti de leur conditions de travail (EVA (Échelle visuelle analogique) médiane=8). Ceci bien qu’ils aient le ressenti de la pression temporelle la plus forte (supérieure à 5 sur 10 dans 71 . Cette dernière est à mettre en perspective avec le fait qu’ils exercent plus souvent sur un mode de temps partiel. Il existe une différence significative du ressenti de la qualité de la formation entre les médecins en formation et les praticiens ayant fini leur cursus (p=0,004).
Conclusion
Le profil particulier du collaborateur médecin pourrait être un élément qui pourrait influencer la collaboration avec la médecine de ville.
Summary
Purpose of the study
The medical demographics in France have been generally declining for several years. In order to limit the decline in the number of occupational physicians, the status of physician collaborator has been created. Our goal is to assess the way working conditions were perceived by physicians and compare it to that of occupational work residents.
Methods
A questionnaire intended to carry out a cross-sectional survey was used. The questionnaire was administered to the targeted population via LimeSurvey. Four universities in the North-West of France where enrollments for both physicians and residents are possible were invited to contribute to our study.
Results
Former occupational medicine interns have the best perception of their working conditions (median VAS=8). Although they felt the greatest time pressure (over 5 out of 10 in 71. The latter should be put into perspective with the fact that they work more often on a part-time basis. There is a significant difference in the perception of the quality of training between doctors in training and full-fledged physicians (P=0.004).
Conclusion
The particular profile of the physician collaborator could be an element which could influence the collaboration with general practioners.
BibTeX:
@article{Sakhri2021,
  author = {Sakhri, R. and Soenen, P. and Géhanno, J. F. and Rollin, L.},
  title = {Comparaison du ressenti des conditions de travail et de l’évaluation de la formation : collaborateurs médecins vs internes},
  month = {November},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2021},
  volume = {82},
  number = {6},
  pages = {577--585},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878521001284},
  doi = {10.1016/j.admp.2021.06.007}
}

BibTeX:
@article{Bouteiller2021,
  author = {Bouteiller, Julie and Grosjean, Julien and Delaunay, Juliette and Jachiet, Marie and Bara, Corina and Nosbaum, Audrey and Bouschon, Pauline and Milpied, Brigitte and Oro, Saskia and Assier, Haudrey and others},
  title = {{\'E}ruptions ecz{\'e}matiformes chroniques du sujet {\^a}g{\'e}: quelle imputabilit{\'e} m{\'e}dicamenteuse?},
  journal = {Annales de Dermatologie et de V{\'e}n{\'e}r{\'e}ologie-FMC},
  publisher = {Elsevier},
  year = {2021},
  volume = {1},
  number = {8},
  pages = {A116--A117},
  doi = {10.1016/j.fander.2021.09.540}
}

Abstract: Introduction
Le syndrome SAPHO (synovite, acné, pustulose palmoplantaire, hyperostose et ostéite) est une entité radio-clinique associant des atteintes articulaires, osseuses et cutanées inflammatoires. La présentation clinique de cette maladie est très hétérogène rendant le diagnostic difficile. La stratégie thérapeutique dans le syndrome SAPHO est mal définie. Le traitement de première intention reste les AINS à la demande qui s’avèrent efficaces pour traiter les poussées douloureuses mais deviennent rapidement insuffisants chez 60 % des cas au cours de l’évolution de la maladie. Les anti-TNF-a sont réservés aux formes réfractaires et leur efficacité est incertaine [1]. Les biphosphonates semblent avoir un intérêt potentiel [2]. L’objectif principal de ce travail était d’étudier la réponse à un traitement par bisphosphonate (BP) et/ou immunosuppresseurs (IS) (cDMARDs) ou biomédicaments (bDMARDs) selon la forme clinique rhumatologique de SAPHO (à prédominance osseuse versus à prédominance articulaire ou mixte).
Patients et méthodes
Ont été inclus dans les centres de Rouen (grâce à l’entrepôt de données de santé), Caen, Le Havre, Dieppe et Lillebonne tous les patients âgés de 18 ans ou plus, atteints d’un syndrome SAPHO répondant aux critères de Benhamou dont les données cliniques, biologiques et radiologiques étaient disponibles dans les dossiers et qui ont bénéficié d’au moins un traitement IS ou BP pour leur maladie. Chaque examen d’imagerie a été relu en aveugle des traitements par un radiologue ayant une expertise en ostéo-articulaire. Les patients étaient classés en 2 groupes (osseux versus articulaire/mixte) selon les données d’imagerie et l’histoire clinique. La réponse au traitement était considérée positive si les symptômes étaient améliorés d’au moins 50 % (cut-off retenu dans la littérature). Un test du Chi2 a été utilisé pour les variables qualitatives, et un test de Kruskal-Wallis pour les variables quantitatives à l’aide du logiciel SPSS.
Résultats
Un total de 34 patients atteints de SAPHO et ayant bénéficié d’un traitement IS ou BP ont été inclus et répartis de la façon suivante : 13 dans le groupe osseux et 21 dans le groupe articulaire ou mixte. Les 2 groupes étaient comparables sur les données démographiques, la durée de suivi, l’âge d’entrée dans la maladie, l’existence d’une atteinte dermatologique ou d’une MICI associée, l’exposition au tabac, la durée d’exposition à un anti-inflammatoire préalable ou à un antibiotique. Seule l’atteinte thoracique antérieure était plus fréquemment notée dans le groupe osseux (p=0,042). L’attitude thérapeutique des prescripteurs différait significativement entre les 2 groupes (p=0,043) avec une prescription plus importante de BP en première ligne dans le groupe osseux (5/13 patients) et un IS dans le groupe articulaire/mixte (19/21). Concernant l’efficacité des traitements, 10/13 patients ont bénéficié d’un traitement efficace sans échappement au cours de leur suivi dans le groupe osseux, ce qui n’était pas significativement différent du groupe articulaire ou mixte (17/21). Les BP ont permis d’obtenir une efficacité sans échappement dans un nombre de cas significativement plus élevé dans le groupe osseux alors qu’il s’agissait des IS dans le groupe articulaire ou mixte (p=0,002). Le groupe osseux a eu recours à un nombre de lignes de traitements spécifiques (IS ou BP) significativement plus faible que dans le groupe articulaire/mixte. (1 ligne spécifique vs au moins 2) (p=0,046).
Conclusion
LLes BP semblent plus efficaces dans le SAPHO avec atteinte osseuse prédominante. Celle-ci semble plus facile à traiter comparativement aux formes articulaires ou mixtes de SAPHO.
BibTeX:
@article{Brevet2021,
  author = {Brevet, P. and Marcelli, C. and Alcaix, D. and Leclancher, A. and Bacquet, H. and Grosjean, J. and Michelin, P. and Lequerré, T. and Vittecoq, O.},
  title = {Étude de la relation entre la nature du traitement et la réponse thérapeutique selon la forme clinique du syndrome {SAHO} à partir d’une cohorte multicentrique normande analysée rétrospectivement},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2021},
  series = {34e {Congrès} {Français} de {Rhumatologie}},
  volume = {88},
  pages = {A113--A114},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833021004385},
  doi = {10.1016/j.rhum.2021.10.179}
}

Abstract: Introduction
Le CEC survient principalement chez des personnes âgées et entraîne une morbidité non négligeable du fait de ses localisations et de son potentiel métastatique. Les CEC localisés aux membres inférieurs ont des caractéristiques cliniques distinctes. Le traitement de référence est la chirurgie et en cas de contre-indication, la radiothérapie est une alternative thérapeutique possible mais cette prise en charge peut s’avérer délicate en cas de localisation à la jambe, de pathologies vasculaires ou de comorbidités, entraînant un retard de cicatrisation. L’objectif de notre étude était d’évaluer quels étaient les facteurs associés à l’absence de cicatrisation à 6 mois après traitement.
Matériel et méthodes
Il s’agissait d’une étude descriptive rétrospective monocentrique sur une cohorte de patients pris en charge en dermatologie pour un CEC localisé à la jambe entre 2000 et 2020. Les données ont été recueillies à partir des dossiers médicaux avec relecture systématique du dossier. Nous avons noté les caractéristiques des patients, du CEC, le type de traitement réalisé, les complications survenues au décours, les récidives locales ou les métastases, la cicatrisation complète à 6 mois après le traitement.
Résultats
Nous avons retenu 100 dossiers sur cette période. L’âge moyen des patients était de 78,4 ans avec une prédominance de femmes (67 . On retrouvait une AOMI dans 6 % des cas, un diabète (13 , une insuffisance veineuse (18 , des troubles neuro-cognitifs (10 . Il s’agissait de CE de novo (78  ou de Marjolin (22 . La chirurgie était le traitement le plus fréquemment réalisé (92, les autres patients étant traités par radiothérapie seule (7  ou immunothérapie (1 . Des complications survenaient chez 18 patients, le plus souvent infectieuses. La cicatrisation complète à 6 mois était obtenue chez 76 patients. À la date des dernières nouvelles 88 % des patients étaient en rémission complète. Chez les patients non cicatrisés on notait un traitement par radiothérapie plus fréquent (20,8 % vs 2,6 , un taux plus élevé de complications (28,6 % vs 16,4 , des comorbidités plus fréquentes (AOMI : 12,5 % vs 3,9 ; insuffisance veineuse : 29,2 % vs 14,5 ; diabète: 29,2 % vs 7,9  et un taux plus élevé de récidive (17,4 % vs 10,6 .
Discussion
Ces résultats montrent un taux élevé de patients non cicatrisés à 6 mois après traitement d’un CEC de jambe, majoré lorsqu’un traitement par radiothérapie a été réalisé et que le patient présente des comorbidités à type de pathologies vasculaires aux membres inférieurs ou de diabète. Ce retard de cicatrisation expose les patients à davantage de complications notamment infectieuses. La recherche et le contrôle de ces facteurs doivent faire partie de la prise en charge globale du patient âgé.
BibTeX:
@article{Huard2021,
  author = {Huard, Emma and Tedbirt, Billal and Mignard, Claire and Grosjean, Julien and Courville, Philippe and Joly, Pascal and Carvalho, Priscille},
  title = {Prise en charge des carcinomes épidermoïdes cutanées localisés aux membres inférieurs. Étude d’une cohorte de 100 patients},
  month = {December},
  journal = {Annales de Dermatologie et de Vénéréologie - FMC},
  year = {2021},
  series = {Journées dermatologiques de {Paris}, 30 novembre - 4 décembre 2021},
  volume = {1},
  number = {8, Supplement 1},
  pages = {A180--A181},
  url = {https://www.sciencedirect.com/science/article/pii/S2667062321003664},
  doi = {10.1016/j.fander.2021.09.089}
}

Abstract: Introduction
Le syndrome de chevauchement polyarthrite rhumatoïde (PR)/sclérodermie systémique (ScS) est une association rare et peu étudiée. Elle concerne 5 % des patients atteints de ScS. Seules des études ouvertes ayant évalué les biomédicaments (bDMARDs) ont rapporté des résultats encourageants, notamment sur l’atteinte articulaire. La prise en charge de ces patients n’est donc pas codifiée. L’objectif était d’analyser en conditions réelles la stratégie thérapeutique et la réponse aux bDMARDS, avec un focus sur l’atteinte articulaire.
Patients et méthodes
Nous avons analysé rétrospectivement sur une période de 10 ans les caractéristiques cliniques, biologiques, radiographiques et la prise en charge thérapeutique des patients respectant les critères diagnostics ACR/EULAR de la PR et de la ScS dans deux centres universitaires. La réponse aux bDMARD a été évaluée sur le plan articulaire (selon les critères EULAR pour 19 séquences, sur le maintien thérapeutique pour 2 séquences) ainsi que sur l’atteinte pulmonaire (évolution des EFR).
Résultats
Vingt-deux patients ont été identifiés. L’atteinte pulmonaire interstitielle était fréquente (n=11). Seulement 7 patients ont été traités uniquement par traitement de fond conventionnel. La molécule la plus utilisée était le méthotrexate. Le recours aux bDMARD était fréquent (15/22), significativement plus important chez les patients ayant des facteurs rhumatoïdes (OR 26,7 ; p=0,004) et avec une tendance chez les patients ayant un plus haut taux d’anti-CCP (160 vs 15 UI ; p=0,11) ou une pneumopathie interstitielle diffuse (OR 10,6 ; p=0,063). Le tocilizumab a été le traitement le plus choisi (n=8) suivi du rituximab (n=5), de l’abatacept et des anti-TNF (n=4 respectivement). Les bDMARD à visée anti-lymphocytaire (abatacept, rituximab) permettaient généralement une réponse bonne ou modérée (n=9/10) avec une diminution significative du DAS28 à 6 mois (−1,75 ; p=0,016). Les bDMARD à visée anti-cytokinique (tocilizumab, etanercept, infliximab) ont moins fréquemment permis un contrôle de l’atteinte articulaire (réponse bonne ou modérée : n=3/9) avec une diminution du DAS28 à 6 mois moins importante (−0,79 ; p=0,36). Deux séquences concernant le tocilizumab ont eu un arrêt précoce pour intolérance ne permettant pas leur évaluation. Un patient a reçu du tofacitinib avec une bonne réponse clinique mais avec un arrêt à 9 mois pour intolérance. Les données EFR n’ont pas évolué significativement sous bDMARD.
Discussion
Le tocilizumab a été fréquemment utilisé, notamment à partir de 2016, date à laquelle une efficacité sur l’atteinte pulmonaire chez les patients atteints de ScS a été évoquée. La forte prévalence de l’atteinte pulmonaire interstitielle dans notre série, notamment chez les patients non contrôlés par traitement de fond conventionnel, a pu influencer le choix thérapeutique. Pour autant le tocilizumab n’a pas permis une bonne réponse sur le plan articulaire dans la majorité des cas.
Conclusion
Chez les patients ayant à la fois une PR et une ScS réfractaire aux traitements de fond conventionnels, les bDMARDs à visée anti-lymphocytaire (abatacept, rituximab) ont permis une amélioration plus fréquente et plus marquée de l’atteinte articulaire que les bDMARD anti-cytokiniques.
BibTeX:
@article{Lebel2021,
  author = {Lebel, N. and Marie, I. and Marcelli, C. and Dumont, A. and Grosjean, J. and Levesque, H. and Leclercq, M. and Lequerré, T. and Benhamou, Y. and Vittecoq, O.},
  title = {Étude observationnelle bi-centrique sur la prise en charge thérapeutique des patients atteints simultanément d’une polyarthrite rhumatoïde et d’une sclérodermie},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2021},
  series = {34e {Congrès} {Français} de {Rhumatologie}},
  volume = {88},
  pages = {A142--A143},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833021004816},
  doi = {10.1016/j.rhum.2021.10.222}
}

Abstract: Introduction
Les anticorps anti-peptides-cycliques-citrullinées (anti-CCP) sont des biomarqueurs fiables pour caractériser les patients atteints de polyarthrite rhumatoïde (PR). Des études ont montré que leur positivité pouvait influencer la réponse aux biomédicaments. L’objectif de notre étude était de déterminer si le titre des anti-CCP à l’introduction du traitement est prédictif de rémission chez les patients traités par abatacept, inhibiteurs du facteur de nécrose tumorale alpha (anti-TNF-α) ou tocilizumab.
Matériels et méthodes
Dans cette étude observationnelle, rétrospective, ont été inclus des patients atteints de PR suivis au C.H.U. de X, traités par abatacept, anti-TNF-α ou par tocilizumab entre octobre 2009 et mai 2021. Les patients ont été séparés en 3 groupes : anti-CCP négatifs, anti-CCP positifstextless340UI/mL et anti-CCP positifstextgreater340UI/mL, et cela pour chaque biomédicament. Pour savoir s’il existe un lien entre le titre des anti-CCP et l’obtention d’une rémission ou d’une faible activité (définies par le DAS28) à 12 mois de traitement, des analyses univariées et multivariées avec ajustement sur les caractéristiques initiales ont été réalisées. Une analyse en sous groupe a également été effectuée en distinguant parmi les patients traités par anti-TNF-α ceux traités par etanercept de ceux traités par un anti-TNF-α monoclonal.
Résultats
Parmi les 329 patients inclus, 99 étaient traités par abatacept (28 anti-CCP négatifs, 40 anti-CCP positifstextless340UI/mL et 31 anti-CCP positifstextgreater340UI/mL), 180 par anti-TNF-α (38 anti-CCP négatifs, 93 anti-CCP positifstextless340UI/mL et 49 anti-CCP positifstextgreater340UI/mL) et 50 par tocilizumab (11 anti-CCP négatifs, 23 anti-CCP positifstextless340UI/mL et 16 anti-CCP positifstextgreater340UI/mL). L’âge médian des patients à l’introduction du traitement était de 57 [47–67] ans. Le sex-ratio était de 2,96 femmes pour 1 homme. La durée d’évolution médiane de la PR avant l’initiation du biomédicament était de 7 [2–12] ans ; 73,6 % des patients présentaient une atteinte structurale. Pour chacune des molécules, les caractéristiques des patients à l’introduction du biomédicament étaient comparables, quel que soit le titre des anti-CCP, sauf pour les facteurs rhumatoïdes (FR) dont la positivité était moins fréquente dans les groupes anti-CCP négatifs. Après analyse univariée puis ajustement sur les caractéristiques initiales, aucune association significative n’a été montrée entre le titre des anti-CCP et la proportion de rémission ou de faible activité chez les patients traités par abatacept, anti-TNF-α ou tocilizumab. Dans l’analyse en sous-groupe, le titre des anti-CCP semblait influencer la rémission avec l’etanercept, mais pas avec les anti-TNF-α monoclonaux. Cette association n’était pas retrouvée en analyse multivariée.
Conclusion
Le titre des anti-CCP à l’introduction du biomédicament n’a pas d’impact sur l’obtention d’une rémission selon le DAS28 après un délai de 12 mois de traitement par abatacept, anti-TNF-α ou tocilizumab.
BibTeX:
@article{protat_impact_2021,
  author = {Protat, P. and Blavier, P. and Vannier, M. and Grosjean, J. and Jouen, F. and Darmoni, S. and Lequerré, T. and Vittecoq, O.},
  title = {Impact du titre des anticorps anti-peptides cycliques citrullinés sur l’obtention de la rémission dans la polyarthrite rhumatoïde traitée par abatacept, tocilizumab ou anti-{TNFα}},
  month = {December},
  journal = {Revue du Rhumatisme},
  year = {2021},
  series = {34e {Congrès} {Français} de {Rhumatologie}},
  volume = {88},
  pages = {A78},
  url = {https://www.sciencedirect.com/science/article/pii/S1169833021003823},
  doi = {10.1016/j.rhum.2021.10.123}
}

BibTeX:
@article{laffouilh232_ontological_2021,
  author = {Pressat Laffouilhère, Thibaut and Grosjean, Julien and Bénichou, Jacques and Darmoni, Stefan J. and Soualmia, Lina F.},
  title = {Ontological {Models} {Supporting} {Covariates} {Selection} in {Observational} {Studies}},
  journal = {Studies in Health Technology and Informatics},
  year = {2021},
  pages = {1095--1096},
  note = {Publisher: IOS Press},
  url = {https://ebooks.iospress.nl/doi/10.3233/SHTI210361},
  doi = {10.3233/SHTI210361}
}

BibTeX:
@article{soualmia_patient_2021,
  author = {Soualmia, Lina F. and Lafon, Vincent and Darmoni, St\&\#233 and J, Fan},
  title = {Patient and {Graph} {Embeddings} for {Predictive} {Diagnosis} of {Drug} {Iatrogenesis}},
  journal = {Public Health and Informatics},
  year = {2021},
  pages = {482--483},
  note = {Publisher: IOS Press},
  url = {https://ebooks.iospress.nl/doi/10.3233/SHTI210205},
  doi = {10.3233/SHTI210205}
}

BibTeX:
@article{Darmoni2001a,
  author = {Stéfan J. Darmoni},
  title = {IA au sein d’un entrepôt de données de santé à Rouen},
  month = {04},
  journal = {Bulletin de l’AfIA},
  year = {2021},
  number = {112},
  pages = {18-20},
  url = {https://afia.asso.fr/wp-content/uploads/2021/05/112_avr21.pdf#page=19}
}

Abstract: Background: Many drugs are still being prescribed in a "off-label mode" and especially in psychiatry. Off-label prescription situations may vary depending on several factors and such practice is not well identifiable in the literature. Methods: A new public academic drug database has been recently created and is able to contain off-label indications, especially in psychiatry in the context of the PSYHAMM French research project. For each situation, bibliographic references have been collected to make the scientific information available to all. Results: this new off-label drug database contains more than 18,154 lines. It is freely available at https://www.hetop.eu/hetop/medicaments. Several off-label usages have been formally described and the system is extensible to all drugs and all specialties. Conclusion: An off-label drug database can be a valuable tool for health professionals and students.
BibTeX:
@techreport{Grosjean2021a,
  author = {Grosjean, Julien and Letord, Catherine and Zana, Ilan and Advenier-Iakovlev, Emanuelle and Duclos, Catherine and Krebs, Marie-Odile and Charlet, Jean and Darmoni, Stefan Jacques},
  title = {Off-label drug database},
  month = {November},
  school = {Health Informatics},
  year = {2021},
  url = {http://medrxiv.org/lookup/doi/10.1101/2021.11.25.21266864},
  doi = {10.1101/2021.11.25.21266864}
}

BibTeX:
@article{Kerdelhue2021,
  author = {Gaétan Kerdelhué and Julien Grosjean and Kévin Billey and Stéfan J Darmoni},
  title = {La base de données bibliographiques LiSSa (Littérature Scientifique en SAnté)},
  month = {Avril-Mai},
  journal = {Le Manipulateur d'imagerie médicale et de radiothérapie},
  year = {2021},
  number = {306},
  pages = {42-46}
}

2020


Abstract: In the context of the COVID-19 pandemic, wearing a face mask has become usual and ubiquitous, in both hospitals and community. However, the general public is consuming surgical or filtering face piece (FFP) masks irrespective of their specificity, leading to global supply shortage for the most exposed persons, which are healthcare workers. This underlines the urgent need to clarify the indications of the different categories of mask, in order to rationalize their use. The study herein specifies the French position for the rational use of respiratory protective equipment for healthcare workers.
BibTeX:
@article{Lepelletier2020,
  author = {Lepelletier, Didier and Grandbastien, Bruno and Romano-Bertrand, Sara and Aho, Serge and Chidiac, Christian and Géhanno, Jean-François and Chauvin, Franck and {French Society for Hospital Hygiene and the High Council for Public Health}},
  title = {What face mask for what use in the context of {COVID}-19 pandemic? {The} {French} guidelines},
  month = {April},
  journal = {The Journal of Hospital Infection},
  year = {2020},
  doi = {10.1016/j.jhin.2020.04.036}
}

Abstract: Background: With the continuous expansion of available biomedical data, efficient and effective information retrieval has become of utmost importance. Semantic expansion of queries using synonyms may improve information retrieval.
Objective: The aim of this study was to automatically construct and evaluate expanded PubMed queries of the form "preferred term"[MH] OR "preferred term"[TIAB] OR "synonym 1"[TIAB] OR "synonym 2"[TIAB] OR …, for each of the 28,313 Medical Subject Heading (MeSH) descriptors, by using different semantic expansion strategies. We sought to propose an innovative method that could automatically evaluate these strategies, based on the three main metrics used in information science (precision, recall, and F-measure).
Methods: Three semantic expansion strategies were assessed. They differed by the synonyms used to build the queries as follows: MeSH synonyms, Unified Medical Language System (UMLS) mappings, and custom mappings (Catalogue et Index des Sites Médicaux de langue Française [CISMeF]). The precision, recall, and F-measure metrics were automatically computed for the three strategies and for the standard automatic term mapping (ATM) of PubMed. The method to automatically compute the metrics involved computing the number of all relevant citations (A), using National Library of Medicine indexing as the gold standard ("preferred term"[MH]), the number of citations retrieved by the added terms ("synonym 1"[TIAB] OR "synonym 2"[TIAB] OR …) (B), and the number of relevant citations retrieved by the added terms (combining the previous two queries with an "AND" operator) (C). It was possible to programmatically compute the metrics for each strategy using each of the 28,313 MeSH descriptors as a "preferred term," corresponding to 239,724 different queries built and sent to the PubMed application program interface. The four search strategies were ranked and compared for each metric.
Results: ATM had the worst performance for all three metrics among the four strategies. The MeSH strategy had the best mean precision (51%, SD 23%). The UMLS strategy had the best recall and F-measure (41%, SD 31% and 36%, SD 24%, respectively). CISMeF had the second best recall and F-measure (40%, SD 31% and 35%, SD 24%, respectively). However, considering a cutoff of 5%, CISMeF had better precision than UMLS for 1180 descriptors, better recall for 793 descriptors, and better F-measure for 678 descriptors.
Conclusions: This study highlights the importance of using semantic expansion strategies to improve information retrieval. However, the performances of a given strategy, relatively to another, varied greatly depending on the MeSH descriptor. These results confirm there is no ideal search strategy for all descriptors. Different semantic expansions should be used depending on the descriptor and the user's objectives. Thus, we developed an interface that allows users to input a descriptor and then proposes the best semantic expansion to maximize the three main metrics (precision, recall, and F-measure).
BibTeX:
@article{Massonnaud2018,
  author = {Massonnaud, Clément R and Kerdelhué, Gaetan and Grosjean, Julien and Lelong, Romain and Griffon, Nicolas and Darmoni, Stefan J},
  title = {Identification of the Best Semantic Expansion to Query PubMed Through Automatic Performance Assessment of Four Search Strategies on All Medical Subject Heading Descriptors: Comparative Study},
  month = {June},
  journal = {JMIR Medical Informatics},
  year = {2020},
  volume = {8},
  number = {6},
  pages = {e12799},
  url = {https://medinform.jmir.org/2020/6/e12799/},
  doi = {10.2196/12799}
}

Abstract: Screening and management of frail elderly patients is essential in general practice.
OBJECTIVE: This study aims to describe and evaluate the knowledge about frailty, its screening tests and management in a population of general practice interns.
METHOD: A prospective, descriptive and mono-centric study using an online survey was conducted. The 2018's promotion of general practice interns in Rouen's University participated. Evaluation of the general knowledge (e.g diagnostic criteria) and specific knowledge (e.g ranking different conditions such as: undernourishment leading to asthenia) and management algorithm (e.g to address the patient for geriatric evaluation) Results: 90 questionnaires were analyzed. Ten interns (11 stated to know at least one screening test or to know a set of 4 major frailty criteria. Thirty four interns knew at least 4 frailty criteria (major or minor) and 46 interns had partial knowledge. Fried's phenotype was the most known. Seventy-five interns (83 stated to know the frailty syndrome. However, 88% of the interns had little knowledge about its pathophysiology. Concerning frailty management, 78% (70 interns) stated to know how to screen frailty and prescribe first line treatments. Thirty-one among them knew how to reassess initial treatment if failure. In 59 interns (65, identifying frailty would have led to a geriatric consultation. Seventy-nine interns (87 were favorable to go through further training on frailty.
CONCLUSION: These general practice interns were able to identify frailty criterion but, in contrast, global understanding of the syndrome was missing. Further training about this topic seems to be necessary.
BibTeX:
@article{Piedallu2020,
  author = {Piedallu, Jean-Baptiste and Lorenzo-Villalba, Noël and Chassagne, Philippe and Schuers, Mathieu and Zulfiqar, Abrar-Ahmad},
  title = {Frailty syndrome: evaluation of its knowledge and screening tools by general medicine interns},
  month = {March},
  journal = {Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement},
  year = {2020},
  volume = {18},
  number = {1},
  pages = {53--62},
  doi = {10.1684/pnv.2019.0840}
}

Abstract: BACKGROUND: The definition and the treatment of male urinary tract infections (UTIs) are imprecise. This study aims to determine the frequency of male UTIs in consultations of general practice, the diagnostic approach and the prescribed treatments.
METHODS: We extracted the consultations of male patients, aged 18 years or more, during the period 2012-17 with the International Classification of Primary Care, version 2 codes for UTIs or associated symptoms from PRIMEGE/MEDISEPT databases of primary care. For eligible consultations in which all symptoms or codes were consistent with male UTIs, we identified patient history, prescribed treatments, antibiotic duration, clinical conditions, additional examinations and bacteriological results of urine culture.
RESULTS: Our study included 610 consultations with 396 male patients (mean age 62.5 years). Male UTIs accounted for 0.097% of visits and 1.44 visits per physician per year. The UTIs most commonly identified were: undifferentiated (52, prostatitis (36, cystitis (8.5 and pyelonephritis (3.5. Fever was recorded in 14% of consultations. Urine dipstick test was done in 1.8% of consultations. Urine culture was positive for Escherichia coli in 50.4% of bacteriological tests. Fluoroquinolones were the most prescribed antibiotics (64.9, followed by beta-lactams (17.4, trimethoprim-sulfamethoxazole (11.9 and nitrofurantoin (2.6.
CONCLUSIONS: Male UTIs are rare in general practice and have different presentations. The definition of male UTIs needs to be specified by prospective studies. Diagnostic evidence of male cystitis may reduce the duration of antibiotic therapy and spare critical antibiotics.
BibTeX:
@article{Soudais2020,
  author = {Soudais, Benjamin and Lacroix-Hugues, Virginie and Meunier, François and Gillibert, André and Darmon, David and Schuers, Matthieu},
  title = {Diagnosis and management of male urinary tract infections: a need for new guidelines. {Study} from a {French} general practice electronic database},
  month = {December},
  journal = {Family Practice},
  year = {2020},
  doi = {10.1093/fampra/cmaa136}
}

BibTeX:
@article{Lesueur2020,
  author = {Lesueur, N. and Gehanno, J.F. and Lefebvre, A. and Michelot, F. and Leroyer, A. and Rollin, L.},
  title = {Facteurs de risques psychosociaux sur l'état de santé du personnel hospitalier : étude comparative dans un centre hospitalier universitaire français},
  journal = {Sciences et bonheur},
  year = {2020},
  volume = {4},
  number = {1},
  pages = {54--72},
  note = {Pages: 4 1 ,54–72},
  url = {https://sciencesetbonheur.files.wordpress.com/2018/09/lesueur-et-al.-2020-sciences-bonheur-volume-4.pdf}
}

Abstract: Résumé
But
En deux décennies, la télédermatologie est devenue une des applications les plus développées de la télémédecine. Son déploiement nécessite d’être accompagné par des évaluations de qualité. Pour réaliser ces évaluations, des indicateurs précis et mesurables doivent être définis. L’objectif de cette étude était d’identifier de manière exhaustive les indicateurs permettant d’évaluer les procédures de télédermatologie et d’évaluer leur pertinence et leurs résultats.
Méthodes
Revue systématique de la littérature conduite sur MEDLINE via PubMed jusqu’en septembre 2017, à partir d’une requête comportant les termes MeSH suivants : « telemedicine », « dermatology », « quality improvement ».
Résultats
La requête a identifié 372 articles, dont 127 ont été retenus. Quatorze indicateurs ont été identifiés et répartis en quatre catégories : indicateurs de processus, de qualité, de coût et de satisfaction. La fiabilité diagnostique de la télédermatologie était l’indicateur le plus souvent évalué (49 études). Elle était globalement bonne comparée à la consultation conventionnelle. Les coûts étaient généralement moindres. Les résultats de certains indicateurs étaient difficiles à comparer et donc à généraliser du fait de l’absence d’instrument de mesure validé, notamment pour la satisfaction.
Conclusion
La télédermatologie est un outil prometteur. Sa mise en place doit s’adapter aux différents besoins des territoires et être réfléchie avec les patients et les différents professionnels de santé concernés. Son évaluation devra également être spécifique à chaque terrain et se baser sur des indicateurs standardisés.
Summary
Aim
Over the last two decades teledermatology has become one of the most widely used applications in telemedicine. Wide-ranging medico-economic evaluations are necessary to facilitate its deployment. “Accurate and measurable” indicators must be defined in order to enable high-quality assessments to be performed. The objective of this study is to identify all indicators allowing evaluation of teledermatology procedures and to assess the relevance and results thereof.
Materials and methods
A literature search until September 2017 was conducted in PubMed using the following MeSH search terms: “telemedicine”, “dermatology” and “quality improvement”.
Results
The search identified 372 articles, of which 127 were included. Fourteen indicators were identified and split into 4 categories: processes indicators, quality indicators, cost indicators and satisfaction indicators. Reliability of diagnosis was the most widely evaluated indicator (49 studies). It was good overall compared to conventional consultations. Costs were generally reduced. Due to the absence of a validated measuring tool, it was difficult to compare the results for certain indicators, particularly satisfaction, and thus to make any generalizations.
Conclusion
Teledermatology is a promising tool. Its deployment must be adapted to the various needs in the field and achievement of this goal requires consultation with patients and with the different healthcare professionals involved. Its evaluation must also be specific to each terrain and must employ standardized measuring instruments.
BibTeX:
@article{Ridard2020,
  author = {Ridard, E. and Secember, H. and Carvalho-Lallement, P. and Schuers, M.},
  title = {Indicateurs en télédermatologie : une revue de la littérature},
  month = {July},
  journal = {Annales de Dermatologie et de Vénéréologie},
  year = {2020},
  url = {http://www.sciencedirect.com/science/article/pii/S0151963820302702},
  doi = {10.1016/j.annder.2020.01.024}
}

BibTeX:
@article{Rollin2020a,
  author = {Rollin, L. and Buisset, C. and Cormorèche, C. and Leroyer, A. and Lenôtre, C. and Gilles, M. and Barlet, B. and Moliné, A.F. and Volkoff, S.},
  title = {Comment " marchent " des chiffres en santé au travail dans l'entreprise ? {A} propos des enjeux sociaux dans les usages de l'observatoire {EVREST}},
  journal = {Références en Santé au Travail},
  year = {2020},
  volume = {162},
  pages = {41--49}
}

Abstract: INTRODUCTION: Return to work after cancer is a determinant of patients quality of life. The aims were to describe return-to-work interventions applied in a French University Hospital and to assess its effectiveness in achieving a successful return to work.
METHODS: A return-to-work questionnaire was sent to 153 patients who were accompanied by a multidisciplinary return-to-work after cancer consultation.
RESULTS: hundred and twenty-one patients answered the return-to-work questionnaire. Analysis of the questionnaire found an overall rate of return to work of 50% two years after the cancer diagnosis. The rate was significantly higher in patients who had received individual psychological support for returning to work (P=0.04) and higher, but not significantly, in patients who had a consultation with the company physician during their period of sick-leave (P=0.08). Participating in support groups and performing the required actions for the recognition of handicapped worker status were not factors associated with return to work.
DISCUSSION: An individual psychological support for returning to work and a consultation with the company physician during the period of sick-leave should be systematically recommended for patients suffering from cancer. Participating in support groups and recognition of handicapped worker status should be recommended on a case-by-case basis.
BibTeX:
@article{Rollin2020,
  author = {Rollin, Laétitia and De Blasi, Geraldine and Boucher, Line and Bouteyre, Evelyne and Gehanno, Jean-François},
  title = {Return-to-work support in cancer patients: {Which} methodology?},
  month = {February},
  journal = {Bulletin Du Cancer},
  year = {2020},
  volume = {107},
  number = {2},
  pages = {200--208},
  doi = {10.1016/j.bulcan.2019.10.006}
}

Abstract: A lexical method was used to map ICD-11 to the terminologies included in the HeTOP server. About half of ICD-11 codes (47.76 were mapped to at least one concept. The developed tool reached a global precision of 0.98 and a recall of 0.66. Lexical methods are powerful methods to map health terminologies. Supervised and manual mapping is still necessary to complete the mapping.
BibTeX:
@article{Grosjean2020,
  author = {Grosjean, Julien and Billey, Kévin and Charlet, Jean and Darmoni, Stefan J.},
  title = {Manual {Evaluation} of the {Automatic} {Mapping} of {International} {Classification} of {Diseases} ({ICD})-11 (in {French}).},
  month = {June},
  journal = {Studies in health technology and informatics},
  year = {2020},
  volume = {270},
  pages = {1335--1336},
  note = {Place: Netherlands},
  url = {http://ebooks.iospress.nl/volume/digital-personalized-health-and-medicine-proceedings-of-mie-2020},
  doi = {10.3233/SHTI200429}
}

BibTeX:
@article{Deroualle2020,
  author = {Deroualle, T. and Dominique, S. and Darmoni, S. and Grosjean, J. and Monti, F. and Lequerré, T. and Vittecoq, O.},
  title = {Les formes rhumatologiques de la sarcoïdose sont associées à un risque accru de développer une spondyloarthrite : résultats d’une étude cas-témoins monocentrique rétrospective},
  month = {December},
  journal = {Revue du rhumatisme},
  year = {2020},
  volume = {87},
  pages = {A98--A99},
  note = {Publisher: Paris : Elsevier},
  url = {https://www.lissa.fr/fr/rep/articles/EL_S1169833020303641},
  doi = {10.1016/j.rhum.2020.10.170}
}

BibTeX:
@inproceedings{Dusenne2020,
  author = {Mikaël Dusenne and Julien Grosjean and Lina Soualmia and Clément Massonnaud and Stéphane Canu and Stéfan J. Darmoni},
  title = {Exploitation de documents médicaux par les techniques d’embedding : application au typage automatique de documents},
  booktitle = {Actes de la journée Santé \& IA},
  month = {Juin},
  year = {2020},
  url = {http://pfia2020.fr/wp-content/uploads/2020/09/actes_journeeSanteIA_2020.pdf}
}

Abstract: Résumé
La crise inédite du Covid-19 a fait apparaitre le besoin de recenser et de diffuser des supports didactiques thérapeutiques à destination des patients (auto-rééducation) en complément des séances, notamment dans le cadre du télésoin. Kinedoc, la banque documentaire francophone, a collaboré avec le D2IM du CHU de Rouen pour créer ce nouveau type de documents en adaptant le moteur de recherche du CISMeF qui recense déjà des publications similaires dans d’autres domaines. Désormais, il sera possible de trouver et de télécharger dans Kinedoc des brochures thérapeutiques dont le Collège de la Masso-Kinésithérapie (CMK) aura préalablement validé la conformité. Chaque société savante, association ou kinésithérapeute/physiothérapeute peut proposer de partager ses « brochures pédagogiques pour le patient », en les envoyant par courriel à cette adresse : secretariat@college-mk.org.
With this unprecedented Covid-19 crisis, appeared the need to draw up a list and to spread pedagogical and therapeutic media for patients (self-rehabilitation), in addition to sessions, particularly in "telehealth". Kinedoc, a French database, collaborated with the D2IM of Rouen’s university hospital to create this new type of documents, adjusting CISMeF’s search engine, which has already listed similar publications in other fields. From now on, it will be possible to find and download in Kinedoc therapeutic brochures certified by the "Collège de la Masso-Kinésithérapie" (CMK). Every academic society, association or physiotherapist can suggest sharing its "pedagogical brochures for patients" by sending them to this address: secretariat@college-mk.org.
BibTeX:
@article{Kerdelhue2020,
  author = {Kerdelhué, Gaétan and Grosjean, Julien and Lejeune, Emeline and Letord, Catherine and Darmoni, Stéfan and Oviève, Jean-Marc and Martin, Laurélyne and Gedda, Michel},
  title = {Kinedoc, {CISMeF} et {COVID}-19: la nécessité de référencer les brochures pédagogiques pour le patient},
  month = {May},
  journal = {Kinésithérapie, la Revue},
  year = {2020},
  url = {http://www.sciencedirect.com/science/article/pii/S1779012320301790},
  doi = {10.1016/j.kine.2020.05.010}
}

BibTeX:
@unpublished{Kiem2020,
  author = {Kiem, C{\'e}cile Tran and Massonnaud, Cl{\'e}ment and Levy-Bruhl, Daniel and Poletto, Chiara and Colizza, Vittoria and Bosetti, Paolo and Gabet, Am{\'e}lie and Olie, Val{\'e}rie and Zanetti, Laura and Bo{\"e}lle, Pierre-Yves and Crepey, Pascal and Cauchemez, Simon},
  title = {{Evaluation des strat{\'e}gies vaccinales COVID-19 avec un mod{\`e}le math{\'e}matique populationnel}},
  month = {December},
  school = {{Haute Autorit{\'e} de Sant{\'e} ; Institut Pasteur Paris ; Sant{\'e} publique France}},
  year = {2020},
  note = {working paper or preprint},
  url = {https://hal-pasteur.archives-ouvertes.fr/pasteur-03087143}
}

Abstract: Europe is now considered as the epicenter of the SARS-CoV-2 pandemic, France being among the most impacted country. In France, there is an increasing concern regarding the capacity of the healthcare system to sustain the outbreak, especially regarding intensive care units (ICU). The aim of this study was to estimate the dynamics of the epidemic in France, and to assess its impact on healthcare resources for each French metropolitan Region. We developed a deterministic, age-structured, Susceptible-Exposed-Infectious-Removed (SEIR) model based on catchment areas of each COVID-19 referral hospitals. We performed one month ahead predictions (up to April 14, 2020) for three different scenarios (R0 = 1.5, R0 = 2.25, R0 = 3), where we estimated the daily number of COVID-19 cases, hospitalizations and deaths, the needs in ICU beds per Region and the reaching date of ICU capacity limits. At the national level, the total number of infected cases is expected to range from 22,872 in the best case (R0 = 1.5) to 161,832 in the worst case (R0 = 3), while the total number of deaths would vary from 1,021 to 11,032, respectively. At the regional level, all ICU capacities may be overrun in the worst scenario. Only seven Regions may lack ICU beds in the mild scenario (R0 = 2.25) and only one in the best case. In the three scenarios, Corse may be the first Region to see its ICU capacities overrun. The two other Regions, whose capacity will be overrun shortly after are Grand-Est and Bourgogne-Franche-Comté. Our analysis shows that, even in the best case scenario, the French healthcare system will very soon be overwhelmed. While drastic social distancing measures may temper our results, a massive reorganization leading to an expansion of French ICU capacities seems to be necessary to manage the coming wave of critically affected COVID-19 patients.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe study was funded by the French national research agency (ANR) through the SPHINx (Spread of Pathogens on Healthcare Institutions Networks) project.Author DeclarationsAll relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.YesAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data and source code are available upon request.
BibTeX:
@article{Massonnaud2020,
  author = {Massonnaud, Cl{\'e}ment and Roux, Jonathan and Cr{\'e}pey, Pascal},
  title = {COVID-19: Forecasting short term hospital needs in France},
  journal = {medRxiv},
  publisher = {Cold Spring Harbor Laboratory Press},
  year = {2020},
  url = {https://www.medrxiv.org/content/early/2020/03/20/2020.03.16.20036939},
  doi = {10.1101/2020.03.16.20036939}
}

Abstract: On March 16 2020, French authorities ordered a large scale lockdown to counter the COVID-19 epidemic wave rising in the country, stopping non-essential economic, educational, and entertainment activities, maintaining mainly food retailers and healthcare institutions. One month later, the number of new hospitalizations and ICU admissions had reached a plateau and were beginning a slow descent.We developed a spatialized, deterministic, age-structured, and compartmental SARS-CoV-2 transmission model able to reproduce the pre-lockdown dynamic of the epidemic in each of the 13 French metropolitan regions. Thanks to this model, we estimate, at regional and national levels, the total number of hospitalizations, ICU admissions, hospital beds requirements (hospitalization and ICU), and hospital deaths which may have been prevented by this massive and unprecedented intervention in France.If no control measures had been set up, between March 19 and April 19 2020, our analysis shows that almost 23% of the French population would have been affected by COVID-19 (14.8 million individuals). Hence, the French lockdown prevented 587,730 hospitalizations and 140,320 ICU admissions at the national level. The total number of ICU beds required to treat patients in critical conditions would have been 104,550, far higher than the maximum French ICU capacity. This first month of lockdown also permitted to avoid 61,739 hospital deaths, corresponding to a 83.5% reduction of the total number of predicted deaths.Our analysis shows that in absence of any control measures, the COVID-19 epidemic would have had a critical morbidity and mortality burden in France, overwhelming in a matter of weeks French hospital capacities.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe study was partly funded by the French national research agency (ANR) through the SPHINx (Spread of Pathogens on Healthcare Institutions Networks) project.Author DeclarationsAll relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.YesAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesSource code is available upon request.
BibTeX:
@article{Roux2020.04.22.20075705,
  author = {Roux, Jonathan and Massonnaud, Cl{\'e}ment and Cr{\'e}pey, Pascal},
  title = {COVID-19: One-month impact of the French lockdown on the epidemic burden},
  journal = {medRxiv},
  publisher = {Cold Spring Harbor Laboratory Press},
  year = {2020},
  url = {https://www.medrxiv.org/content/early/2020/04/27/2020.04.22.20075705},
  doi = {10.1101/2020.04.22.20075705}
}

BibTeX:
@article{Trost2020,
  author = {Trost, Olivier and Crampon, Frédéric and Prum, Grégoire and Trouilloud, Pierre and Duparc, Fabrice},
  title = {A plea to remove the word "condyle" from the international anatomical nomenclature},
  month = {January},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2020},
  volume = {42},
  number = {1},
  pages = {95--96},
  doi = {10.1007/s00276-019-02296-7}
}

2019


Abstract: PURPOSE: Nasomaxillary fractures can be mistaken for fractures confined to the nasal bones, resulting in inappropriate treatments that jeopardize patient outcomes. Our purpose here was to provide information on nasomaxillary fractures via a retrospective study and literature review. MATERIAL AND METHODS: We retrospectively collected clinical, computed tomography (CT), therapeutic, and outcome data in consecutive patients managed for unilateral impacted nasomaxillary fractures at our centre over a 5-year period (2013-2017). Long-term outcomes were further assessed by administering scoring tools for subjectively assessed cosmesis, nasal obstruction, and pain during a telephone interview. RESULTS: The 11 included patients had a mean age of 33.4 years. The clinical manifestations included nasal asymmetry in all 11 patients and infra-orbital rim step-off deformity in 9 patients. Consistent CT findings were involvement of the nasal bone, canine pillar, and anterior maxillary bone; and presence of blood within the maxillary sinus. The treatment in 8 patients consisted in open reduction and internal fixation via the intraoral approach, with or without an added infra-orbital approach; 1 patient was managed by endonasal reduction and 2 patients declined reduction. Almost 1 year after surgery, the cosmetic outcome was good (mean score, 22/25) and few patients reported nasal obstruction (mean score, 3.6/20) or pain (mean score, 1.6/10). CONCLUSION: Nasomaxillary fracture is a specific entity that must be differentiated from nasal bone fracture. Open reduction and internal fixation via the intraoral approach, with an added infra-orbital approach if needed, provides good outcomes.
BibTeX:
@article{Adnot2019a,
  author = {Adnot, J. and Desbarats, C. and Joly, L.-M. and Trost, O.},
  title = {Nasomaxillary fracture: Retrospective review of 11 consecutive patients and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  volume = {120},
  number = {6},
  pages = {534--539},
  doi = {10.1016/j.jormas.2019.03.003}
}

Abstract: Dental rehabilitation raises specific challenges in patients with mandibular fibrous dysplasia. We report the 2-year post-operative outcomes on the normal and affected sides in a 64-year-old female with focal left mandibular fibrous dysplasia and bilateral posterior edentulism. On the left, bone shaving of the lesion to restore sufficient vertical height was followed by the insertion of two dental implants. Three dental implants were inserted into the normal bone on the right. Dental prostheses were added 6 months later. Two years after the first procedure, no complications had been recorded and the patient reported similar high satisfaction for both sides. This comparison of outcomes of dental implants inserted into dysplastic versus normal bone in the same patient suggests that dental implants may constitute a valid option for managing edentulism in selected patients with fibrous dysplasia, provided appropriate precautions are taken.
BibTeX:
@article{Adnot2019,
  author = {Adnot, J. and Moizan, H. and Trost, O.},
  title = {Dental implants in a patient with left mandibular fibrous dysplasia: Two-year outcomes on the normal and affected sides},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  volume = {120},
  number = {6},
  pages = {575--578},
  doi = {10.1016/j.jormas.2019.02.005}
}

Abstract: BACKGROUND: Extracting concepts from biomedical texts is a key to support many advanced applications such as biomedical information retrieval. However, in clinical notes Named Entity Recognition (NER) has to deal with various types of errors such as spelling errors, grammatical errors, truncated sentences, and non-standard abbreviations. Moreover, in numerous countries, NER is challenged by the availability of many resources originally developed and only suitable for English texts. This paper presents the Cimind system, a multilingual system dedicated to named entity recognition in medical texts based on a phonetic similarity measure. METHODS: Cimind performs entity recognition by combining phonetic recognition using the DM phonetic algorithm to deal with spelling errors and string similarity measures. Three main steps are processed to identify terms in a controlled vocabulary: normalization, candidate selection by phonetic similarity and candidate ranking. RESULTS: Cimind was evaluated in the 2016 and 2017 editions of the CLEF eHealth challenge in the CepiDC/CDC tasks. In 2017, it obtained on each corpus the following results: English dataset: 83.9% P, 78.3% R, 81.0% F1; French raw dataset: 85.7% P, 68.9% R, 76.4% F1; French aligned dataset: 83.5% P, 77.5% R, 80.4% F1. It ranked first in French and fourth in English in officials runs.
BibTeX:
@article{Cabot2019,
  author = {Cabot, Chloe and Darmoni, Stefan and Soualmia, Lina F.},
  title = {Cimind: {A} phonetic-based tool for multilingual named entity recognition in biomedical texts.},
  month = {June},
  journal = {Journal of biomedical informatics},
  year = {2019},
  volume = {94},
  pages = {103176},
  doi = {10.1016/j.jbi.2019.103176}
}

Abstract: PURPOSE: The objective of this study was to record the descriptive and metric anatomical characteristics of the thyrohyoid nerve with the aim of rerouting it in a selective laryngeal reinnervation procedure. METHODS: An anatomical study was performed on ten formalin-embalmed cadavers. The origin of the thyrohyoid nerve and the superior root of the ansa cervicalis, the location of the thyrohyoid nerve ending in the thyrohyoid muscle, and the recurrent laryngeal nerve were established. Then, a rerouting of the thyrohyoid nerve was performed. We measured the length of thyrohyoid nerve, the distance between the thyrohyoid nerve ending and the recurrent laryngeal nerve at the horizontal level of the cricothyroid joint before and after the rerouting, and the distance between the origin of the thyrohyoid nerve and the superior root of the ansa cervicalis. RESULTS: The thyrohyoid nerve was identified on both sides in all the cases. The average length of the thyrohyoid nerve was 27 mm. The end of the thyrohyoid nerve was found in 100% of the cases at the upper outer quarter of the thyrohyoid muscle. After the rerouting, an average reduction of 30% of the distance between the end of the thyroid nerve and the recurrent laryngeal nerve at the horizontal level of the cricothyroid joint was measured. CONCLUSION: The rerouting of the thyrohyoid nerve provided a reduction in the length of the nerve graft in laryngeal reinnervation. Moreover, the constancy of the thyrohyoid nerve and its characteristics make it a valuable anatomical base for laryngeal reinnervation and laryngeal innervated allotransplantation.
BibTeX:
@article{Crampon2019,
  author = {Crampon, Frédéric and Duparc, Fabrice and Trost, Olivier and Marie, Jean-Paul},
  title = {Selective laryngeal reinnervation: can rerouting of the thyrohyoid nerve simplify the procedure by avoiding the use of a nerve graft?},
  month = {February},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2019},
  volume = {41},
  number = {2},
  pages = {145--150},
  doi = {10.1007/s00276-018-2117-y}
}

Abstract: INTRODUCTION: Guidelines concerning the follow-up of subjects occupationally exposed to lung carcinogens, published in France in 2015, recommended the setting up of a trial of low-dose chest CT lung cancer screening in subjects at high risk of lung cancer. OBJECTIVE: To evaluate the organisation of low-dose chest CT lung cancer screening in subjects occupationally exposed to lung carcinogens and at high risk of lung cancer. METHODS AND ANALYSIS: This trial will be conducted in eight French departments by six specialised reference centres (SRCs) in occupational health. In view of the exploratory nature of this trial, it is proposed to test initially the feasibility and acceptability over the first 2 years in only two SRCs then in four other SRCs to evaluate the organisation. The target population is current or former smokers with more than 30 pack-years (who have quit smoking for less than 15 years), currently or previously exposed to International Agency for Research on Cancer group 1 lung carcinogens, and between the ages of 55 and 74 years. The trial will be conducted in the following steps: (1) identification of subjects by a screening invitation letter; (2) evaluation of occupational exposure to lung carcinogens; (3) evaluation of the lung cancer risk level and verification of eligibility; (4) screening procedure: annual chest CT scans performed by specialised centres and (5) follow-up of CT scan abnormalities. ETHICS AND DISSEMINATION: This protocol study has been approved by the French Committee for the Protection of Persons. The results from this study will be submitted to peer-reviewed journals and reported at suitable national and international meetings. TRIAL REGISTRATION NUMBER: NCT03562052; Pre-results.
BibTeX:
@article{Delva2019,
  author = {Delva, Fleur and Laurent, François and Paris, Christophe and Belacel, Milia and Brochard, Patrick and Bylicki, Olivier and Chouaïd, Christos and Clin, Benedicte and Dewitte, Jean-Dominique and Le Denmat, Véronique and Gehanno, Jean-François and Lacourt, Aude and Margery, Jacques and Verdun-Esquer, Catherine and Mathoulin-Pélissier, Simone and Pairon, Jean-Claude},
  title = {LUCSO-1-French pilot study of LUng Cancer Screening with low-dose computed tomography in a smokers population exposed to Occupational lung carcinogens: study protocol},
  journal = {BMJ open},
  year = {2019},
  volume = {9},
  number = {3},
  pages = {e025026},
  doi = {10.1136/bmjopen-2018-025026}
}

Abstract: Background: Word embedding technologies are now used in a wide range of applications. However, no formal evaluation and comparison have been made on models produced by the three most famous implementations (Word2Vec, GloVe and FastText).
Objective: The goal of this study is to compare embedding implementations on a corpus of documents produced in a working context, by health professionals.
Methods: Models have been trained on documents coming from the Rouen university hospital. This data is not structured and cover a wide range of documents produced in a clinic (discharge summary, prescriptions ...). Four evaluation tasks have been defined (cosine similarity, odd one, mathematical operations and human formal evaluation) and applied on each model.
Results: Word2Vec had the highest score for three of the four tasks (mathematical operations, odd one similarity and human validation), particularly regarding the Skip-Gram architecture.
Conclusions: Even if this implementation had the best rate, each model has its own qualities and defects, like the training time which is very short for GloVe or morphosyntaxic similarity conservation observed with FastText. Models and test sets produced by this study will be the first publicly available through a graphical interface to help advance French biomedical research.
BibTeX:
@article{Dynomant2019,
  author = {Dynomant, Emeric and Lelong, Romain and Dahamna, Badisse and Massonaud, Clément and Kerdelhué, Gaétan and Grosjean, Julien and Canu, Stéphane and Darmoni, Stefan J},
  title = {Word embedding for {French} natural language in healthcare: a comparative study},
  month = {April},
  journal = {JMIR Medical Informatics},
  year = {2019},
  pages = {30},
  doi = {10.2196/12310}
}

Abstract: BACKGROUND: Clinical research is mostly conducted among hospitalized patients, which restricts the generalizability of research results. The involvement of GPs in research has been consistently highlighted as a factor associated with successful study recruitment. OBJECTIVES: To assess GPs' motivations and willingness to participate in primary care research as investigators and to identify factors associated with their willingness. METHODS: We conducted an observational, cross-sectional study in Normandy, France, with a self-questionnaire sent to 3002 GPs. We collected data on GPs' socio-demographic characteristics, their experiences and their expectations regarding research, and their reasons for non-participation. RESULTS: Overall, 489 questionnaires were collected. Two hundred and forty-six GPs (50.3%) were interested in participating in clinical research as investigators. The two main conditions for participation as investigators were the relevance of the study topic for clinical practice (80.5%) and the feedback of study results (80.1%). The two main reasons for non-participation were lack of time (79.4%) and administrative burden (43.6%). Age between 27 and 34 years (adjusted odds ratio [AOR] = 2.86, P = 0.004) and GP trainer status (AOR = 2.41, P < 0.001) were associated with willingness to participate in primary care research. Age between 60 and 70 years (AOR = 0.53, P = 0.03) and locum status (AOR = 0.40, P = 0.04) were associated with non-participation in research. CONCLUSIONS: Based on our results, we were able to establish a profile of GPs willing to participate in primary care research as investigators. GPs' involvement should be based on their preferred areas of research. Different incentives such as a dedicated clinical research nurse or financial support could also be considered.
BibTeX:
@article{FerrandDevouge2019,
  author = {Ferrand Devouge, Eglantine and Biard, Morgane and Beuzeboc, Jean and Tavolacci, Marie-Pierre and Schuers, Matthieu},
  title = {Motivations and willingness of general practitioners in France to participate in primary care research as investigators},
  journal = {Family Practice},
  year = {2019},
  volume = {36},
  number = {5},
  pages = {552--559},
  doi = {10.1093/fampra/cmy126}
}

Abstract: BACKGROUND: Childhood obesity (CO) has become a true epidemic and a subject of increasing publications. The aim of this study was to assess if the number of publications in that field increases over time in proportion to the epidemic, and also according to socioeconomic factors.
METHODS: A PubMed search was carried out to extract articles related to CO published between 1945 and 2017. Data were downloaded from PubMed and processed through a dedicated parser. Socioeconomic data were collected from international organizations.
RESULTS: Overall, 36,554 articles were retrieved among 3329 journals, one-third of them being concentrated in 44 journals. The annual growth rate of publications on CO was on average 11.6% per year between 1990 and 2016, whereas the growth rate of articles on pediatrics or of the total articles indexed in MEDLINE was 2.6% and 4.4 respectively. The most productive countries were the United States (37.80, the United Kingdom (6.24, and Italy (4.56. There was a significant relationship between publications on CO in a country and prevalence of CO in that country (p = 0.002) and between evolution of the number of publications and evolution of the Human Development Index (p = 0.01). Following exponential growth, CO publications reached a plateau in 2013, whereas publications targeted on obesity in infants continue to increase.
CONCLUSIONS: Research on CO has risen markedly in the last two decades, with a higher growth rate than biomedical research overall, as a result of the worldwide obesity epidemic and also due to specific socioeconomic factors.
BibTeX:
@article{Gehanno2019,
  author = {Gehanno, Jean-Francois and Gehanno, Bogna and Schuers, Mathieu and Grosjean, Julien and Rollin, Laetitia},
  title = {Analysis of {Publication} {Trends} in {Childhood} {Obesity} {Research} in {PubMed} {Since} 1945},
  month = {March},
  journal = {Childhood Obesity (Print)},
  year = {2019},
  volume = {15},
  number = {4},
  pages = {227--236},
  doi = {10.1089/chi.2018.0276}
}

Abstract: INTRODUCTION: The pharmaceutical record system (PRS) is a French nationwide centralized electronic database shared among all community pharmacists listing all drugs dispensed by community pharmacists in the last four months. The objective of this study, the Medication Assessment Through Real time Information eXchange - Distributed Pharmaceutical Record System (MATRIX - DPRS) study, was to assess the clinical impact of the PRS upon granting access to physicians in three hospital specialties: anesthesiology, emergency medicine and geriatrics. MATERIAL AND METHODS: A multicenter prospective study was conducted in six hospital departments, two per specialty. Participating physicians noted medication information found exclusively in the pharmaceutical record (PR) of each patient unavailable elsewhere and any diagnostic or therapeutic management changes resulting from the PR information. The primary objective was to assess the proportion of diagnostic or therapeutic management changes attributable to the PR among patients who had an accessible PR. RESULTS: The inclusion level ranged from 1.1 to 30% in the six departments. The rate of diagnostic or therapeutic management changes was highest in geriatrics (n = 31/67; 46.3% 95% Confidence IntervaI (CI): 34.0-58.9 and lowest in anesthesiology (n = 36/227; 15.9% 95% CI: 11.4-21.3. Emergency medicine was intermediate (n = 5/22; 22.7% 95% CI: 7.8-45.4. CONCLUSION: Although the inclusion rate and statistical precision were low, these findings suggest that the information contained in the PRS is useful and may result in modifying patient management in a sizeable proportion of patients. This opens the prospect of evaluating other hospital specialties, as well as primary and secondary care settings.
BibTeX:
@article{Gillibert2019,
  author = {Gillibert, Andre and Griffon, Nicolas and Schuers, Matthieu and Hardy, Kristell and Elmerini, Amine and Letord, Catherine and Staccini, Pascal and Darmoni, Stefan J. and Benichou, Jacques},
  title = {Impact on medical practice of accessing pharmaceutical records},
  month = {January},
  journal = {International journal of medical informatics},
  year = {2019},
  volume = {121},
  pages = {58--63},
  doi = {10.1016/j.ijmedinf.2018.09.010}
}

Abstract: INTRODUCTION: La classification internationale des soins primaires, deuxième version (CISP-2) alignée sur la classification internationale des maladie dixième révision (CIM-10) est un standard pour le recueil épidémiologique en soins primaires. La CISP-2 convient aussi pour identifier les thèmes cliniques dont discutent les médecins de famille. Les domaines contextuels de connaissances spécifiques à la médecine de famille et aux Soins Primaires comme les structures, la gestion, les catégories de patients, les méthodes de recherche, les aspects éthiques ou environnementaux ne sont pas standardisés et reflètent le plus souvent des vues d'experts. METHODES: une méthode de recherche qualitative, appliquée à l'analyse de plusieurs congrès de médecine de famille a permis d'identifier, en plus des items cliniques, un ensemble de concepts contextuels abordés par les médecins de famille lors de leurs échanges pendant les congrès. Assemblés sous forme hiérarchique, ces concepts ont trouvé leur place au côté de la CISP-2, sous le nom de Q-codes version 2.5, sur le serveur sémantique multilingue multi-terminologique du Département d'Information et d'Informatique médicale (D2IM) de l'Université de Rouen, France. Les deux classifications sont éditées sous le sigle 3CGP pour Core Content Classification of General Practice. Ce serveur d'accès libre permet de consulter la CISP-2 en 22 langues et les Q-codes en dix langues. RESULTATS: le résultat de l'utilisation conjointe de ces deux classifications, comme descripteurs dans des congrès, pour identifier des concepts dans des textes, ou indexer la littérature grise en médecine de famille et soins primaires est présenté ici dans différentes utilisations pilotes. La validité et la généralisabilité de 3CGP semble bonne au vu des traductions déjà réalisées par des collègues du monde entier et de l'applicabilité de la méthode des deux côtés de l'Atlantique. Toute fois la reproductibilité et la variation inter-codeurs restent encore à tester pour les Q-codes. La question de la maintenance reste posée. CONCLUSION: grâce à cette méthode, on peut mettre en évidence l'extension conceptuelle, la complexité et la dynamique du métier de médecin généraliste et de famille et de médecin de soins primaires.
BibTeX:
@article{Jamoulle2019,
  author = {Jamoulle, Marc and Augusto, Daniel Knupp and Pizzanelli, Miguel and Tavares, Ariana De Oliveira and Resnick, Melissa and Grosjean, Julien and Darmoni, Stefan},
  title = {Une base de connaissance multilingue et dynamique en ligne pour la médecine générale et les soins primaires},
  journal = {Pan African Medical Journal},
  year = {2019},
  volume = {32},
  url = {http://www.panafrican-med-journal.com/content/article/32/66/full/},
  doi = {10.11604/pamj.2019.32.66.15952}
}

Abstract: Background: The huge amount of clinical, administrative and demographic data recorded and maintained by hospitals can be consistently aggregated into Health Data Warehouses (HDWs) with a uniform data model. In 2017, Rouen University Hospital (RUH) initiated the design of a Semantic Health Data Warehouse (SHDW) enabling both semantic description and retrieval of health information.
Objective: Our objectives were: first, to present a proof of concept of this SHDW, based on the data of 250,000 patients from RUH and second, to assess its ability to assist health professionals to select patients in a clinical trials context.
Methods: The SHDW relies on three distinct semantic layers: (a) a Terminology and Ontology (T&O) portal, (b) a Semantic Annotator and (c) a Semantic Search Engine and a Not Only SQL (NoSQL) layer to enhance data access performances. The system adopts an entity-centered vision which contrasts with the usually patient-centered vision adopted by existing systems such as Informatics for Integrating Biology and the Bedside (i2b2). This vision notably provides generic search capabilities able to express data requirements in terms of the whole set of interconnected conceptual entities that compose health information. We assessed the ability of the system to assist the search for 95 inclusion and exclusion criteria originating from five randomly chosen Clinical Trials from RUH.
Results: The system succeeded in fully automating 39.19% of the criteria and was efficiently used as a pre-screening tool for 72.97% of them.
Conclusions: The semantic aspect of the system combined with its generic entity-centered vision enables the processing of a large range of clinical questions. However, an important part of health information remains in Clinical Narratives and we are currently investigating novel approaches (deep learning) to enhance the semantic annotation of those unstructured data.
BibTeX:
@article{Lelong2019,
  author = {Lelong, Romain and Soualmia, Lina F and Grosjean, Julien and Taalba, Mehdi and Darmoni, SJ},
  title = {Building a {Semantic} {Health} {Data} {Warehouse}: {Evaluation} of a search tool in {Clinical} trials},
  journal = {JMIR Medical Informatics},
  year = {2019},
  pages = {30},
  doi = {10.2196/13917}
}

BibTeX:
@article{Maquet2019,
  author = {Maquet, C. and Evrard, M. and Kerbrat, J.-B. and Bastien, A.-V. and Adnot, J. and Trost, O.},
  title = {A case of severe facial palsy following bimaxillary osteotomy: It is time to update the pre-surgery patient fact sheet},
  month = {September},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  doi = {10.1016/j.jormas.2019.08.013}
}

Abstract: BACKGROUND: Despite growing access to effective therapies, asthma control still needs improvement. Many non-drug factors, such as allergens, air pollutants and stress also affect asthma control and patient quality of life, but an overview of the effectiveness of non-drug interventions on asthma control was lacking.
OBJECTIVES: To identify non-drug interventions likely to improve asthma control.
METHODS: A systematic review of the available literature in Medline and the Cochrane Library was conducted in March 2017, without any time limit. Initial searching identified 884 potentially relevant clinical trial reports, literature reviews and meta-analyses, which were screened for inclusion using criteria of quality, relevance, and reporting outcomes based on asthma control.
RESULTS: Eighty-two publications met the inclusion criteria. In general, the quality of the studies was low. Patient education programmes (22 studies) significantly improved asthma control. Multifaceted interventions (10 studies), which combined patient education programmes with decreasing exposure to indoor allergens and pollutants, significantly improved asthma control based on clinically relevant outcomes. Renovating homes to reduce exposure to allergens and indoor pollutants improved control (two studies). Air filtration systems (five studies) were effective, especially in children exposed to second-hand smoke. Most measures attempting to reduce exposure to dust mites were ineffective (five studies). Dietary interventions (eight studies) were ineffective. Promoting physical activity (five studies) tended to yield positive results, but the results did not attain significance.
CONCLUSION: Twenty-six interventions were effective in asthma control. Simultaneously combining several action plans, each focusing on different aspects of asthma management, seems most likely to be effective.
BibTeX:
@article{Schuers2019,
  author = {Schuers, Matthieu and Chapron, Anthony and Guihard, Hugo and Bouchez, Tiphanie and Darmon, David},
  title = {Impact of non-drug therapies on asthma control: {A} systematic review of the literature},
  month = {March},
  journal = {The European Journal of General Practice},
  year = {2019},
  pages = {1--12},
  doi = {10.1080/13814788.2019.1574742}
}

Abstract: INTRODUCTION:
Research in family medicine is necessary to improve the quality of care. The number of publications in general medicine remains low. Databases from Electronic Medical Records can increase the number of these publications. These data must be coded to be used pertinently. The objective of this study was to assess the quality of semantic annotation by a multi-terminological concept extractor within a corpus of family medicine consultations.
METHOD:
Consultation data in French from 25 general practitioners were automatically annotated using 28 different terminologies. The data extracted were classified into three groups: reasons for consulting, observations and consultation results. The first evaluation led to a correction phase of the tool which led to a second evaluation. For each evaluation, the precision, recall and F-measure were quantified. Then, the inter- and intra-terminological coverage of each terminology was assessed.
RESULTS:
Nearly 15,000 automatic annotations were manually evaluated. The mean values for the second evaluation of precision, recall and F-measure were 0.85, 0.83 and 0.84 respectively. The most common terminologies used were SNOMED CT, SNOMED 3.5 and NClt. The terminologies with the best intra-terminological coverage were ICPC-2, DRC and CISMeF Meta-Terms.
CONCLUSION:
A multi-terminological concepts extractor can be used for the automatic annotation of consultation data in family medicine. Integrating such a tool into general practitioners' business software would be a solution to the lack of routine coding. Developing the use of a single terminology specific to family medicine could improve coding, facilitate semantic interoperability and the communication of relevant information.
BibTeX:
@article{Siefridt2019,
  author = {Charlotte Siefridt and Julien Grosjean and Tatiana Lefebvre and Laetitia Rollin and Stéfan Darmoni and Matthieu Schuers},
  title = {Evaluation of automatic annotation by a multi-terminological concepts extractor within a corpus of data from family medicine consultations},
  journal = {International Journal of Medical Informatics},
  year = {2019},
  doi = {10.1016/j.ijmedinf.2019.104009}
}

Abstract: Résumé
Les médecins du travail évoquent souvent des difficultés à réaliser du maintien dans l’emploi pour les salariés vus en visite de pré-reprise en fin d’indemnisation par l’assurance maladie, le recours à l’inaptitude étant souvent inévitable. L’objectif de l’étude était d’étudier le devenir des salariés, notamment l’impact sur le contrat de travail en fonction d’une notification de fin d’indemnisation journalière (IJ) préalable à la réalisation de la visite de pré-reprise (VPR) mais également renseigner les délais de réalisation des différentes étapes du processus de maintien.
Méthode
Dans cette étude descriptive transversale, durant 6 mois en 2016–2017, pour les salariés adressés en visite de pré-reprise par le médecin conseil de l’assurance maladie, les médecins du travail de Haute Normandie ont été invités à compléter un questionnaire retraçant le parcours de maintien en emploi du salarié, l’avis du médecin du travail sur la possibilité de maintien en emploi et le devenir du contrat de travail.
Résultats
Parmi les visites de pré-reprise réalisées (n=641), 40 % (n=255) d’entre elles faisaient l’objet d’une notification de fin d’IJ lors de leur réalisation et 65 % (n=415) comportaient un avis du médecin du travail sur la possibilité de maintien dans l’emploi. La proportion de salariés pouvant être maintenue au travail selon le médecin du travail était de 52 %. Elle était significativement moins importante dans le groupe ayant eu une notification de fin d’indemnités journalières que dans le groupe n’en ayant pas eu (36 % vs 70  p=0,001).
Conclusion
Cette étude démontre bien l’intérêt de la coordination des acteurs en terme de maintien dans l’emploi, notamment au niveau médical. Elle invite les différents acteurs à prendre le temps nécessaire, afin de prévenir la désinsertion professionnelle.
Summary
Occupational health physicians often describe return to work difficulties for patients having notification of end of indemnisation of sick leave by health insurance. The aim of the study was to assess the professional employees becoming, especially consequence on the working contract, according to notification of end of indemnisation of sick leave by health insurance, and to describe delays of the different return to work steps.
Methods
In this descriptive transversal study, during 6 months in 2016–2017, Upper Normandy's occupational physicians completed a questionnaire for employees in sick leave who where addressed by the insurance health physician. Questions were about possibility of return to work according to the occupational physician, return to work process and the evolution of the work contract.
Results
On 641 return to work consultations, 40% (n=255) had notification of end of indemnisation of sick leave by health insurance and 65% (n=415) mentioned the occupational health physician opinion about the possibility of return to work. Occupational health physician declared possibility for return to work for 52% of employees. This proportion was significantly lower for employees who had a notification of end of indemnisation of sick leave by health insurance. (36% vs. 70 P=0.001).
Conclusion
Coordination between return to work professionnals, particularly occupational health physicians and insurance health physicians is an important factor to improve employees’ return to work.
BibTeX:
@article{Courtois2019,
  author = {Courtois, R. and Lefebvre, A. and Gehanno, J. -F. and Rollin, L.},
  title = {La visite de pré-reprise avec notification de fin d’indemnités journalières : un facteur défavorable au maintien dans l’emploi ?},
  month = {April},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2019},
  volume = {80},
  number = {2},
  pages = {108--114},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878518308038},
  doi = {10.1016/j.admp.2018.11.004}
}

BibTeX:
@article{Desbarats2019,
  author = {Desbarats, C. and Adnot, J. and Bastien, A. V. and Trost, O.},
  title = {Histiocytose langerhansienne révélée par un désordre de l’appareil manducateur : rapport d’un cas et revue de la littérature des atteintes crâniofaciales.},
  month = {August},
  journal = {La Revue de médecine interne},
  year = {2019},
  url = {https://www.lissa.fr/fr/rep/articles/31474430},
  doi = {10.1016/j.revmed.2019.08.005}
}

Abstract: Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevention mostly relies on mechanical protection (clothes covering most parts of the body) that may be completed by chemical protection (repulsives). Secondary prevention relies on early detection of ticks after exposure, and mechanical extraction. There is currently no situation in France when prophylactic antibiotics would be recommended. The incidence of Lyme borreliosis in France, estimated through a network of general practitioners (réseau Sentinelles), and nationwide coding system for hospital stays, has not significantly changed between 2009 and 2017, with a mean incidence estimated at 53 cases/100,000 inhabitants/year, leading to 1.3 hospital admission/100,000 inhabitants/year. Other tick-borne diseases are much more seldom in France: tick-borne encephalitis (around 20 cases/year), spotted-fever rickettsiosis (primarily mediterranean spotted fever, around 10 cases/year), tularemia (50-100 cases/year, of which 20% are transmitted by ticks), human granulocytic anaplasmosis (<10 cases/year), and babesiosis (<5 cases/year). The main circumstances of diagnosis for Lyme borreliosis are cutaneous manifestations (primarily erythema migrans, much more rarely borrelial lymphocytoma and atrophic chronic acrodermatitis), neurological (<15% of cases, mostly meningoradiculitis and cranial nerve palsy, especially facial nerve) and rheumatologic (mostly knee monoarthritis, with recurrences). Cardiac and ophtalmologic manifestations are very rarely encountered.
BibTeX:
@article{Figoni2019,
  author = {Figoni, J. and Chirouze, C. and Hansmann, Y. and Lemogne, C. and Hentgen, V. and Saunier, A. and Bouiller, K. and Gehanno, J. F. and Rabaud, C. and Perrot, S. and Caumes, E. and Eldin, C. and de Broucker, T. and Jaulhac, B. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Gocko, X. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J. P. and Degeilh, B. and Partouche, H. and Lenormand, C. and Sotto, A. and Raffetin, A. and Monsuez, J. J. and Michel, C. and Boulanger, N. and Cathebras, P. and Tattevin, P. and endorsed by scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {318--334},
  doi = {10.1016/j.medmal.2019.04.381}
}

Abstract: BACKGROUND: In France, complex cases of occupational disease (OD) are submitted to regional committees who are in charge of accepting, or rejecting, the claim. Their mean annual acceptance rate varies from one region to another, which may reflect differences in the cases, or discrepancies between committees. The objective of this study was to assess the comparability of the decisions of the committees on the basis of standardized cases.
METHODS: Three experienced occupational physicians specialized in OD were asked to develop 28 clinical cases representative of claims for compensation usually seen in these committees. The cases, in the form of short vignettes, were submitted to the 18 French regional committees, asking if they would recognise each case as an OD.
RESULTS: All committees participated. The acceptance rate (recognition of the case as an OD) varied, ranging from 18% to 70%. All the committees took the same decision for only 7 out of the 28 cases, but half accepted and half refused for 3 cases. For 10 cases, one quarter of the committees gave a decision different than the other 75%. The highest discordance rates were observed for the cases concerning musculoskeletal disorders and asbestos related diseases.
CONCLUSION: The committees take very different decisions in terms of recognition of OD, especially for the most frequently compensated OD in France, i.e. musculoskeletal disorders and asbestos related diseases. This is a major source of injustice for the employees who seek compensation and there is a need to develop methods to harmonize decisions between committees.
BibTeX:
@article{Gehanno2019b,
  author = {Gehanno, J.-F. and Letalon, S. and Gislard, A. and Rollin, L.},
  title = {Inequities in occupational diseases recognition in {France}},
  month = {July},
  journal = {Revue D'epidemiologie Et De Sante Publique},
  year = {2019},
  volume = {67},
  number = {4},
  pages = {247--252},
  doi = {10.1016/j.respe.2019.04.054}
}

BibTeX:
@article{Gocko2019,
  author = {Gocko, X. and Lenormand, C. and Lemogne, C. and Bouiller, K. and Gehanno, J.-F. and Rabaud, C. and Perrot, S. and Eldin, C. and de Broucker, T. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Sobas, C. and Jaulhac, B. and Figoni, J. and Chirouze, C. and Hansmann, Y. and Hentgen, V. and Caumes, E. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J.-P. and Degeilh, B. and Partouche, H. and Saunier, A. and Sotto, A. and Raffetin, A. and Monsuez, J.-J. and Michel, C. and Boulanger, N. and Cathebras, P. and Tattevin, P. and endorsed by the following scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {296--317},
  doi = {10.1016/j.medmal.2019.05.006}
}

Abstract: The serodiagnosis of Lyme borreliosis is based on a two-tier strategy: a screening test using an immunoenzymatic technique (ELISA), followed if positive by a confirmatory test with a western blot technique for its better specificity. Lyme serology has poor sensitivity (30-40%) for erythema migrans and should not be performed. The seroconversion occurs after approximately 6 weeks, with IgG detection (sensitivity and specificity both>90%). Serological follow-up is not recommended as therapeutic success is defined by clinical criteria only. For neuroborreliosis, it is recommended to simultaneously perform ELISA tests in samples of blood and cerebrospinal fluid to test for intrathecal synthesis of Lyme antibodies. Given the continuum between early localized and disseminated borreliosis, and the efficacy of doxycycline for the treatment of neuroborreliosis, doxycycline is preferred as the first-line regimen of erythema migrans (duration, 14 days; alternative: amoxicillin) and neuroborreliosis (duration, 14 days if early, 21 days if late; alternative: ceftriaxone). Treatment of articular manifestations of Lyme borreliosis is based on doxycycline, ceftriaxone, or amoxicillin for 28 days. Patients with persistent symptoms after appropriate treatment of Lyme borreliosis should not be prescribed repeated or prolonged antibacterial treatment. Some patients present with persistent and pleomorphic symptoms after documented or suspected Lyme borreliosis. Another condition is eventually diagnosed in 80% of them.
BibTeX:
@article{Jaulhac2019,
  author = {Jaulhac, B. and Saunier, A. and Caumes, E. and Bouiller, K. and Gehanno, J. F. and Rabaud, C. and Perrot, S. and Eldin, C. and de Broucker, T. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Sobas, C. and Gocko, X. and Figoni, J. and Chirouze, C. and Hansmann, Y. and Hentgen, V. and Cathebras, P. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J. P. and Degeilh, B. and Partouche, H. and Lenormand, C. and Sotto, A. and Raffetin, A. and Monsuez, J. J. and Michel, C. and Boulanger, N. and Lemogne, C. and Tattevin, P. and endorsed by scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies (II). Biological diagnosis, treatment, persistent symptoms after documented or suspected Lyme borreliosis},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {335--346},
  doi = {10.1016/j.medmal.2019.05.001}
}

Abstract: Objectifs : L’objectif principal de cette étude était de décrire la méthodologie de redressement utilisée dans le cadre de l’observatoire « Évolution et relations en santé au travail » (Évrest). Les objectifs secondaires étaient, d’une part, d’apprécier l’ampleur des écarts entre les estimations brutes et pondérées et, d’autre part, de vérifier que le décalage de deux années dans la disponibilité des données de référence utilisées n’impactait pas substantiellement les estimations produites.
Méthodes : L’étude a porté sur les données recueillies en 2013 et 2014 (n = 26 227). Le redressement a comporté deux étapes : 1) la prise en compte de la probabilité de participation de chaque salarié ; 2) le calage sur marges pour corriger les éventuelles distorsions de l’échantillon par rapport au champ de l’enquête, les données de référence utilisées provenant des déclarations annuelles de données sociales (DADS) des années 2014 et 2012. L’impact du redressement a été analysé sur les 60 variables du questionnaire par l’étude des écarts entre les pourcentages bruts et pondérés.
Résultats : Au total, 90 % des écarts observés entre estimations brutes et pondérées étaient compris entre – 2,0 % et + 2,0 % avec les DADS 2014, 83 % avec les DADS 2012. L’estimation brute la plus surestimée concernait le travail à temps plein et celle la plus sous-estimée, le contact avec le public. L’impact d’un décalage de deux années des données de référence était faible, quelle que soit la variable étudiée.
Conclusion : Une méthodologie de redressement pour l’observatoire Évrest a été définie et mise en œuvre, permettant d’extrapoler les résultats à l’ensemble des salariés du champ de l’enquête.
BibTeX:
@article{Leroyer2019,
  author = {Leroyer, Ariane and Murcia, Marie and Chastang, Jean-François and Rollin, Laétitia and Volkoff, Serge and Molinié, Anne-Françoise and Niedhammer, Isabelle},
  title = {Méthodologie de redressement des données nationales de l’enquête Évrest},
  journal = {Sante Publique},
  year = {2019},
  volume = {Vol. 31},
  number = {5},
  pages = {645--655},
  url = {https://www.cairn.info/revue-sante-publique-2019-5-page-645.htm},
  doi = {10.3917/spub.195.0645}
}

Abstract: Compensation for occupational pulmonary diseases requires the establishment of guidelines based on standardized and objective criteria, in order to provide compensation that is as fair as possible to patients who suffer from them. A review of the elements necessary for the examination of an individual file was carried out by a working group. It is accepted that respiratory functional exploration is the key element in assessing the level of permanent disability in all of these conditions, with the exception of thoracic malignancies. Guiding scales have been developed for the respiratory impairment of three types of conditions: occupational asthma, thoracic malignancy, and other respiratory diseases. Additional criteria for increasing the permanent disability level are also proposed in order to take into account professional prejudice, in particular the possibility or not of continuing the occupational activity, in the same job or after changing to another. For certain respiratory diseases, a periodic reassessment of the initially attributed permanent disability level is recommended as well as the initial one at the time of definitive cessation of occupational activity.
BibTeX:
@article{Pairon2019,
  author = {Pairon, J.-C. and Azoury, H. and Catto, M. and Dalphin, J.-C. and Gehanno, J.-F. and Housset, B. and L'huillier, J.-P. and Serveau, S. and Straus, C.},
  title = {Comment évaluer en 2019 les taux d’incapacité permanente des pathologies professionnelles pulmonaires ?},
  month = {March},
  journal = {Revue Des Maladies Respiratoires},
  year = {2019},
  volume = {36},
  number = {3},
  pages = {307--325},
  doi = {10.1016/j.rmr.2018.07.007}
}

Abstract: OBJECTIVES: To conduct an audit of vaccination practices against pertussis in maternity wards to assess immunization practices targeting women, knowledge and awareness among health professionals and their involvement in the vaccination process, and to estimate their vaccine coverage. MATERIALS AND METHODS: 2017 cross-sectional descriptive survey using a data collection sheet of immunization practices targeting women and an anonymous questionnaire for health professionals whose vaccine coverage had been documented by the occupational health service. RESULTS: Five public maternity wards participated: one had a vaccination policy for women; 426 of 822 health professionals completed the questionnaire, 76% (from 50% of all residents to 83% of nurses) declared their vaccination status as up to date. Staff files in occupational health services showed that 69% of 822 health professionals received at least one vaccine booster during adulthood (57% less than 10 years before the survey); documented vaccination coverage rates ranged from 75% for residents to 91% for senior physicians. Occupational physicians and family physicians respectively performed 41% and 34% of vaccinations. While knowledge regarding vaccines was good, only 47% of health professionals declared prescribing them and 18% declared administering the anti-pertussis vaccine "often" or "very often". CONCLUSIONS: Updated data is needed to confirm the reported increase as participating centers are not representative of all birth centers. The active role of health professionals in vaccination-based pertussis prevention needs to be reinforced.
BibTeX:
@article{Pellissier2019,
  author = {Pellissier, G. and Lolom, I. and Cairati, N. and Cherifi, C. and Amiel-Taieb, C. and Farbos, S. and Caillaud, V. and Gaudelus, J. and Gozlan, C. and Pinquier, D. and Gehanno, J. F. and Luton, D. and Bouvet, E. and Abiteboul, D.},
  title = {Maternity staff immunization coverage against pertussis and maternal vaccination practices: Results of a 2017 cross-sectional survey in five public maternity hospitals},
  month = {July},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  doi = {10.1016/j.medmal.2019.07.009}
}

Abstract: Return to work is a public health priority which led the French Health Authority to publish recommendations about "return to work and health: prevention of exclusion from work". The aim of this article is to present a literature review of return to work after cancer. Studies about medium-term and long-term effects of cancer are sparse. They suggest worker durable effects. Factors associated with return to work are linked to the patient characteristics, to characteristics of the illness and the treatment, to the workplace and to the help provided to the patient during the return to work process. A specific plan for returning to work in 3 phases (situation comprehension, identification of negative and positive factors for returning to work, implementation of measures concerning the patient, the workplace and the coordination between return to work actors) should be built for each patient, involving the worker, the occupational practitioner, the general and specialist practitioners.
BibTeX:
@article{Rollin2019a,
  author = {Rollin, Laétitia and Fantoni-Quinton, Sophie and Petit, Audrey and Baumann, Camille and Petitprez, Karine and Gehanno, Jean-François and Fassier, Jean-Baptiste},
  title = {Maintien en emploi des patients atteints de cancer},
  month = {November},
  journal = {Bulletin Du Cancer},
  year = {2019},
  volume = {106},
  number = {11},
  pages = {1039--1049},
  doi = {10.1016/j.bulcan.2019.08.008}
}

Abstract: Résumé
Introduction
Les travailleurs du nucléaire peuvent être exposés à la contamination interne par des particules chaudes (particules insolubles radioactives d’un diamètre variant de 10 micromètres à 1 millimètre). Actuellement, aucun modèle biocinétique théorique décrivant l’évolution d’une telle contamination n’a été décrit par la Commission internationale de protection radiologique. L’objectif de ce travail était d’évaluer une nouvelle méthode pour estimer l’activité d’une particule chaude dans l’organisme.
Méthode
Plusieurs mesures anthropogammamétriques ont été réalisées à l’aide d’un fantôme anthropomorphe dénommé « Igor » dans lequel une source radioactive d’activité connue a été insérée. Igor est constitué de briques élémentaires permettant de simuler différentes localisations d’une particule chaude au sein de l’abdomen. Ces différentes mesures ont permis d’établir un facteur correctif à l’activité mesurée pour chaque localisation de la source. Afin de déterminer la position de la particule chaude dans l’abdomen du travailleur, deux examens anthropogammamétriques successifs lui sont réalisés (face puis dos). Le facteur correctif correspondant à la position estimée est ensuite appliqué à l’activité mesurée. Cette méthode a ensuite été utilisée dans un cas réel de contamination interne, en complément des examens radiotoxicologiques des selles.
Résultats
Au total, 24 mesures ont été réalisées pour tenir compte des différentes localisations de la particule chaude dans l’abdomen, du poids du sujet (70–90kg) et du type de radionucléide impliqué. Les facteurs correctifs étaient de 0,68–0,84 (source antérieure) et 1,78–2,09 (source postérieure) en configuration 70kg et de 0,95–1,43 et 2,24–3,15 en configuration 90kg. L’application de cette méthode a un cas réel de contamination interne a permis d’estimer l’activité d’une particule chaude entre 76 800 et 90 250 Becquerel. L’activité éliminée dans les selles était de 82 523 Becquerel.
Conclusion
Cette nouvelle méthode permet d’estimer plus rapidement l’activité réelle d’une particule chaude et pourrait être un outil complémentaire à la réalisation des examens radiotoxicologiques des selles dont l’observance est parfois imparfaite.
Summary
Purpose of the study
Nuclear power plants workers can be exposed to internal contamination via hot particles (radioactive insoluble particles with a 10 micrometers to 1 millimeter wide diameter). At present, no theoretical biokinetic model describing the contamination by these particles has been designed by the International Commission on Radiological Protection. The objective of this work was to describe a new method to estimate the activity of a hot particle in the body.
Method
Several whole-body measurements were realized using an anthropomorphic ghost called “Igor” into which a radioactive source of known activity was inserted. Igor is constituted with elementary bricks allowing to feign the various locations of a hot particle within the abdomen. These various measures allowed to establish a corrective factor in the activity measured for every location of the source. To determine the position of the hot particle in the worker abdomen, two whole-body measures were successively realized (face then back). The corrective factor corresponding to the estimated position is then applied to the moderate activity. This method was then used in a real case of internal contamination, in parallel faeces analysis were realized.
Results
In total, 24 measures were realized to consider various locations of the hot particle in the abdomen, the weight of the subject (70–90kg) and the type of radionuclides involved. The corrective factor was 0.68–0.84 (source front) and 1.78–2.09 (source posterior) in configuration 70kg and of 0.95–1.43 and 2.24–3.15 for 90kg. The application of this method in a real case of internal contamination allowed to estimate the activity of a hot particle between 76,800 and 90,250 Becquerel. The real activity according to the faecal examinations was 82,523 Becquerel.
Conclusion
This new method allows to estimate more quickly the real activity of a hot particle and could be a complementary tool to faeces analysis as collecting is sometimes troublesome.
BibTeX:
@article{Sailly2019,
  author = {Sailly, M. and Le-Couteulx, I. and Bocquet, I. and Gehanno, J. F. and Rollin, L.},
  title = {Travailleur du nucléaire : activité d’une particule chaude incorporée},
  month = {February},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2019},
  volume = {80},
  number = {1},
  pages = {39--46},
  url = {https://www.sciencedirect.com/science/article/pii/S1775878518308051},
  doi = {10.1016/j.admp.2018.10.009}
}

Abstract: Even if, English is generally used for international communication, it is essential to keep in mind that research is running at the local level by local teams generally communicating in their local/national language. Bearing these in mind, the "European Federation for Medical Informatics Working Group on Health Informatics for Inter-regional Cooperation" has as one of its objectives, to develop a multilingual dictionary focusing on Health Informatics as a collaboration tool allowing improving international and more particularly European cooperation. This dictionary is implemented as a part of HeTOP (Health Terminology/Ontology Portal) which is currently integrating more than 70 terminologies and ontologies in 32 languages. The EFMI Dictionary main aims are helping medical librarians, translators, academic and industrial researchers understanding better one another and supporting students self-learning.
BibTeX:
@inproceedings{Benis2019,
  author = {Benis, Arriel and Crisan-Vida, Mihaela and Stoicu-Tivadar, Lacramioara and Darmoni, Stefan},
  title = {A {Multi}-{Lingual} {Dictionary} for {Health} {Informatics} as an {International} {Cooperation} {Pillar}.},
  booktitle = {ICIMTH 2019, the 17th International Conference on Informatics, Management and Technology in Healthcare},
  month = {July},
  journal = {Studies in health technology and informatics},
  year = {2019},
  volume = {262},
  pages = {31--34},
  doi = {10.3233/SHTI190009}
}

Abstract: The ApiAppS ongoing project aims to provide physicians with a decision support system for the prescription / recommendation of mHealth technologies. We describe the context and the components of the project which includes: 1) a technical part on modelling and implementing the decision support system, and 2) a psychosocial investigation part designed to have a better knowledge of general practitioners (GPs) and patients' expectations, beliefs and practices.
BibTeX:
@inproceedings{Dufour2019,
  author = {Dufour, Jean-Charles and Grosjean, Julien and Darmoni, Stefan and Yasini, Mobin and Marchand, Guillaume and Simon, Christian and Sarradon-Eck, Aline and Préau, Marie and Darmon, David and Schuers, Matthieu and Hassanaly, Parina and Giorgi, Roch},
  title = {{ApiAppS}: {A} {Project} to {Study} and {Help} {Practitioners} in {Recommending} {mHealth} {Apps} and {Devices} to {Their} {Patients}},
  booktitle = {MEDINFO 2019: Health and Wellbeing e-Networks for All},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2019},
  volume = {264},
  pages = {1919--1920},
  doi = {10.3233/SHTI190713}
}

Abstract: Structuring raw medical documents with ontology mapping is now the next step for medical intelligence. Deep learning models take as input mathematically embedded information, such as encoded texts. To do so, word embedding methods can represent every word from a text as a fixed-length vector. A formal evaluation of three word embedding methods has been performed on raw medical documents. The data corresponds to more than 12M diverse documents produced in the Rouen hospital (drug prescriptions, discharge and surgery summaries, inter-services letters, etc.). Automatic and manual validation demonstrates that Word2Vec based on the skip-gram architecture had the best rate on three out of four accuracy tests. This model will now be used as the first layer of an AI-based semantic annotator.
BibTeX:
@inproceedings{Dynomant2019a,
  author = {Dynomant, Emeric and Lelong, Romain and Dahamna, Badisse and Massonnaud, Clément and Kerdelhué, Gaëtan and Grosjean, Julien and Canu, Stéphane and Darmoni, Stéfan},
  title = {Word {Embedding} for {French} {Natural} {Language} in {Healthcare}: {A} {Comparative} {Study}},
  booktitle = {MEDINFO 2019: Health and Wellbeing e-Networks for All},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2019},
  volume = {264},
  pages = {118--122},
  doi = {10.3233/SHTI190195}
}

Abstract: Information science is a fast-changing field, and medical librarians need to develop their roles to meet the users’new requirements. The professional development becomes a major challenge, not only regarding the core activities, but also in the way librarians and users can learn in a more innovative way. In order to invent new tools for training, a group of librarians with different backgrounds decided to create a game inspired by the “Bucket ofdoom”, which is described as a “Card game that meets storytelling with a sprinkling of comedy”. This adapted version for health libraries will face players with real professional situations. To overcome each challenge and have fun, librarians must use their experience and imagination with a high dose of creativity and humour.
BibTeX:
@article{Gomez-Sanchez2019,
  author = {Alicia Gómez-Sánchez and Gaétan Kerdelhue and Rebeca Isabel-Gómez and Mar González-Cantalejo and Pablo Iriarte and Floriane Muller},
  title = {Health libraries: sharing through gaming},
  month = {September},
  journal = {Journal of EAHIL},
  year = {2019},
  volume = {15},
  number = {3},
  pages = {8-11},
  url = {http://ojs.eahil.eu/ojs/index.php/JEAHIL/article/view/329},
  doi = {10.32384/jeahil15329}
}

Abstract: Il n’existe pas de standard universellement accepté pour nommer les médicaments. L’identification du médicament a fait l’objet de nombreux travaux de normalisation. Notre objectif est de définir un modèle formel du médicament en français pour lier les différentes entités manipulables autour du médicament. Ce modèle formel vise un double sous-objectif : (a) créer et instancier une ontologie formelle du médicament ; (b) créer une terminologie du médicament, intégrable dans un serveur de terminologies. À terme, ces ressources seront des outils puissants pour, notamment, supporter la recherche d’information dans des bases de médicaments ou des entrepôts de données. Ils seront mis librement à disposition de la communauté.
BibTeX:
@inproceedings{Grosjean2019,
  author = {Julien Grosjean and Catherine Letord and Jean Charlet and Xavier Aimé and Loane Danès and Julien Rio and Ilan Zana and Stéfan J Darmoni and Catherine Duclos},
  title = {Un modèle sémantique d’identification du médicament en France},
  booktitle = {Atelier IA \& Santé},
  address = {Toulouse},
  month = {Juillet},
  year = {2019}
}

Abstract: Introduction
Les technologies de l’information et de la communication ont permis la naissance du web 2.0, caractérisé par la mise en place et l’utilisation de nouveaux outils collaboratifs de communication tels que les blogs, les wikis, les fils RSS et les réseaux sociaux. En s’appropriant ces outils, une médecine participative basée sur le partage d’informations et d’expériences entre professionnels, patients et tout acteur de la santé s’est développée. Depuis juin 2012, une communauté médicale échange sur Twitter avec le hashtag DocTocToc et contribue à la naissance de la e-santé sur ce réseau social. L’objectif de cette étude est d’analyser les principales thématiques des demandes effectuées via le hashtag DocTocToc par les médecins généralistes entre juin 2012 et mars 2017.
Méthodes
Une collecte de données par une méthode de « web scraping » a permis de constituer un corpus de tweets dont les auteurs ont été identifiés manuellement afin de procéder à un échantillonnage, de façon à ne conserver que les tweets émis par les médecins généralistes. Une étape de prétraitement a permis de transformer les formes potentiellement non reconnues par les logiciels de traitement du langage naturel. Le corpus a été appréhendé à l’aide de deux approches : une approche lexicale via le logiciel Iramuteq® et une indexation terminologique par l’extracteur de concepts multi-terminologiques (ECMT) du Catalogue et index des sites médicaux francophones (CISMeF).
Résultats
Sur les 12 716 tweets recueillis, 7366 étaient rédigés par des médecins généralistes et ont été analysés. L’approche lexicale détermine deux grands mondes lexicaux représentés sous forme de dendrogramme, l’un en lien avec les demandes médico administratives relatives à la gestion du cabinet et à la prise en charge sociale du patient, l’autre en lien avec les demandes d’ordre purement médicales. La méthode d’indexation terminologique met en évidence les spécialités médicales pourvoyeuses de demandes de télé-expertise : gynécologie, neurologie, infectiologie, pédiatrie, cardiologie, dermatologie ; et permet de les croiser avec l’objectif de la demande : diagnostic, thérapeutique.
Conclusion
Sur Twitter®, le hashtag DocTocToc est utilisé par les médecins généralistes comme un espace de partage informel d’informations en matière de santé mais aussi de gestion de problèmes administratifs et sociaux. Le DocsTocToc se présente comme un groupe d’échange de pratique à grande échelle ou le médecin compte sur l’avis de ses pairs.(Fig. 1)
BibTeX:
@article{Salles2019,
  author = {Salles, A. and Dufour, J. and Hassanaly, P. and Michel, P. and Cabot, C. and Grosjean, J.},
  title = {Analyse du discours médical sur {Twitter}®. Étude d’un corpus de tweets émis par des médecins généralistes entre juin 2012 et mars 2017 et contenant le hashtag \#{DocTocToc}},
  month = {May},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2019},
  series = {{EPICLIN} 2019},
  volume = {67},
  pages = {S152--S153},
  url = {http://www.sciencedirect.com/science/article/pii/S0398762019301993},
  doi = {10.1016/j.respe.2019.03.027}
}

Abstract: Introduction
Les établissements de santé sont tenus d’assurer la traçabilité des dispositifs médicaux (DM). À l’enjeu sanitaire sous la responsabilité de la pharmacie, s’ajoute un enjeu financier concernant les DM de la liste en sus. Devant l’absence à ce jour d’une base d’associations exhaustives de tous les DM Cladimed et des actes médicaux de la Classification commune des actes médicaux (CCAM), le CHU de Rouen a débuté ce projet.
Méthodes
Sur la base des activités du Programme de médicalisation du système d’information (PMSI) de l’activité Médecine, chirurgie et obstétrique (MCO) 2016 et 2017 du CHU de Rouen, l’ensemble des cooccurrences entre les actes CCAM et les codes Cladimed des DM (sur la liste en sus ou non) ont été identifiées de manière automatisée. Ensuite, dans le domaine de la cardiologie interventionnelle, une validation experte a été réalisée. Enfin, cette base préliminaire a été implémentée sur l’activité MCO de janvier à septembre 2018 de notre établissement, grâce à un outil écrit en Python, afin de l’évaluer.
Résultats
Sur les 113 284 RSS analysés, seuls 768 comportaient des actes de cardiologie interventionnelle ; 24 % de ces séjours comportaient au moins une erreur avérée : 5 % codes actes CCAM erronés et/ou oubli de traçabilité de DM en SUS, 10 % de nouvelles activités médicales et/ou nouveaux codes Cladimed 2018, 20 % erreurs de quantité de DM et 16 % incohérence qualitative d’association de DM. Cependant, 48 % des erreurs initiales pointaient des limites de paramétrage de notre programme.
Discussion/Conclusion
Ces résultats préliminaires montrent ainsi la possibilité d’améliorer la qualité du codage des actes CCAM et la traçabilité sanitaire de tous les DM. En effet, cet outil permettrait un contrôle a posteriori renforcé pour les services d’information médicale et de pharmacie. Des mises à jour seront évidemment nécessaires des classifications CCAM et Cladimed et des associations dans notre base. Par ailleurs, l’élargissement progressif de notre base d’associations à toutes les autres spécialités est notre ultime objectif.
BibTeX:
@article{Ndangang2019,
  author = {Ndangang, M. and Aussy, K. and Grosjean, J. and Tanguy, L.},
  title = {Intérêt d’une base d’associations exhaustives d’actes de la classification commune des actes médicaux et de dispositifs médicaux : un projet en cours au {CHU} de {Rouen}, {France}},
  month = {March},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2019},
  series = {{IIe} {Congrès} national {Emois} {Colloque} organisé par l’{Association} {Evaluation}, management, organisation, santé ({Emois}) {Livre} des résumés présentés au congrès},
  volume = {67},
  pages = {S112},
  url = {https://www.sciencedirect.com/science/article/pii/S0398762019301129},
  doi = {10.1016/j.respe.2019.01.111}
}

Abstract: PubMed is the biggest and most used bibliographic database worldwide, hosting more than 26M biomedical publications. One of its useful features is the "similar articles" section, allowing the end-user to find scientific articles linked to the consulted document in term of context. The aim of this study is to analyze whether it is possible to replace the statistic model PubMed Related Articles (pmra) with a document embedding method. Doc2Vec algorithm was used to train models allowing to vectorize documents. Six of its parameters were optimised by following a grid-search strategy to train more than 1,900 models. Parameters combination leading to the best accuracy was used to train models on abstracts from the PubMed database. Four evaluations tasks were defined to determine what does or does not influence the proximity between documents for both Doc2Vec and pmra. The two different Doc2Vec architectures have different abilities to link documents about a common context. The terminological indexing, words and stems contents of linked documents are highly similar between pmra and Doc2Vec PV-DBOW architecture. These algorithms are also more likely to bring closer documents having a similar size. In contrary, the manual evaluation shows much better results for the pmra algorithm. While the pmra algorithm links documents by explicitly using terminological indexing in its formula, Doc2Vec does not need a prior indexing. It can infer relations between documents sharing a similar indexing, without any knowledge about them, particularly regarding the PV-DBOW architecture. In contrary, the human evaluation, without any clear agreement between evaluators, implies future studies to better understand this difference between PV-DBOW and pmra algorithm.
BibTeX:
@article{Dynomant2019b,
  author = {Dynomant, Emeric and Darmoni, Stéfan J. and Lejeune, Émeline and Kerdelhué, Gaëtan and Leroy, Jean-Philippe and Lequertier, Vincent and Canu, Stéphane and Grosjean, Julien},
  title = {Doc2Vec on the {PubMed} corpus: study of a new approach to generate related articles},
  month = {November},
  journal = {arXiv:1911.11698 [cs]},
  year = {2019},
  note = {arXiv: 1911.11698},
  url = {http://arxiv.org/abs/1911.11698}
}

BibTeX:
@article{Trost2019,
  author = {Trost, Olivier and Micoud, Stéphane and Duparc, Fabrice},
  title = {Comments about the article "A Crouzon syndrome from the classic period of Maya civilization?" The art historian's point of view},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2019},
  volume = {41},
  number = {12},
  pages = {1529--1530},
  doi = {10.1007/s00276-019-02302-y}
}

Abstract: Les données cliniques sont produites par différents professionnels de santé, dans divers lieux et sous diverses formes dans le cadre de la pratique de la médecine. Elles présentent par conséquent une hétérogénéité à la fois au niveau de leur nature et de leur structure mais également une volumétrie particulièrement importante et qualifiable de massive. Le travail réalisé dans le cadre de cette thèse s’attache à proposer une méthode de recherche d’information efficace au sein de ce type de données complexes et massives. L’accès aux données cliniques se heurte en premier lieu à la nécessité de modéliser l’informationclinique. Ceci peut notamment être réalisé au sein du dossier patient informatisé ou, dans une plus large mesure, au sein d’entrepôts de données. Je propose dans ce mémoire unepreuve de concept d’un moteur de recherche permettant d’accéder à l’information contenue au sein de l’entrepôt de données de santé sémantique du Centre Hospitalier Universitaire de Rouen. Grâce à un modèle de données générique, cet entrepôt adopte une vision de l’information assimilable à un graphe de données rendant possible la modélisation de cette information tout en préservant sa complexité conceptuelle. Afin de fournir des fonctionnalités de recherche adaptées à cette représentation générique, un langage de requêtes permettant l’accès à l’information clinique par le biais des diverses entités qui la composent a été développé et implémenté dans le cadre de cette thèse. En second lieu, la massivité des données cliniques constitue un défi technique majeur entravant la mise en oeuvre d’une recherche d’information efficace. L’implémentation initiale de la preuve de concept sur un système de gestion de base de données relationnel a permis d’objectiver les limites de ces derniers en terme de performances. Une migration vers un système NoSQL orienté clé-valeur a été réalisée. Bien qu’offrant de bonnes performances d’accès atomique aux données, cette migration a également nécessité des développements annexes et la définition d’une architecture matérielle et applicative propice à la mise en oeuvre des fonctionnalités de recherche et d’accès aux données. Enfin, l’apport de ce travail dans le contexte plus général de l’entrepôt de données de santé sémantique du CHU de Rouen a été évalué. La preuve de concept proposée dans ce travail a ainsi été exploitée pour accéder aux descriptions sémantiques afin de répondre à des critères d’inclusion et d’exclusion de patients dans des études cliniques. Dans cette évaluation, une réponse totale ou partielle a pu être apportée à 72,97% des critères. De plus, la généricité de l’outil a également permis de l’exploiter dans d’autres contextes tels que la recherche d’information documentaire et bibliographique en santé.
BibTeX:
@phdthesis{Lelong2019a,
  author = {Romain Lelong},
  title = {Accès sémantique aux données massives et hétérogènes en santé},
  month = {June},
  school = {Normandie Université},
  year = {2019},
  url = {https://tel.archives-ouvertes.fr/tel-02287217}
}

2018


Abstract: INTRODUCTION: Oral metastases from hepatocellular carcinoma (HCC) are very rare, and predominate in the mandible. We report an exceptional case of maxillary metastasis revealing HCC. CASE REPORT: A 56-year-old man with a previous medical history of alcohol abuse presented to our department with a 3-week evolving oral mass. Physical examination showed a left maxillary tumor. The biopsy revealed a HCC and a multi-metastatic HCC with portal thrombosis and a pulmonary embolism was discovered following a CT-scan. A state of advanced malnutrition contraindicated sorafenib chemotherapy. Thus, external irradiation was proposed, without success. The patient subsequently died 50 days later. DISCUSSION: Maxillary HCC metastases are extremely rare. The average age of HCC jaw metastases appearance in patients has been reported to be approximately 57 years, men are more affected than women are, and the mean life expectancy is 12 months following the diagnosis. These patients require palliative treatment. Local recurrences occur very early after possible surgery, and expose the patient to life-threatening bleeding.
BibTeX:
@article{Adnot2018,
  author = {Adnot, J. and Gemival, P. and Trost, O.},
  title = {Maxillary metastasis from a hepatocellular carcinoma: Report of an uncommon presentation and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2018},
  volume = {119},
  number = {6},
  pages = {503--505},
  doi = {10.1016/j.jormas.2018.07.001}
}

Abstract: BACKGROUND: General practice became an academic discipline quite recently in many western countries. In France, junior lecturer work is specified in a three-part mandate: medical work in general practice, teaching in the university, and research. Since 2007, 130 junior lecturers have been appointed in general practice. The aim of the creation of junior lecturer status was to align general practice with other specialties and to develop research and education in primary care.
OBJECTIVES: To describe the healthcare, teaching and research undertaken by junior lecturers in general practice, practising in October 2014.
METHODS: A cross-sectional multicentre study using an online self-administered questionnaire on the cohort composed of all the junior lecturers in general practice with open questions and the qualitative analysis of written verbatim accounts.
RESULTS: Of the 95 junior lecturers practising at the date of the study, 75 (79 responded; average age 32 years; gender ratio (F/M) 2.4:1. They spent five, two and three half-days per week respectively in healthcare, teaching and research. The healthcare activity was predominantly carried out in the community (73. Thirty-nine per cent worked as part of a multi-professional team taking on 50 consultations per week. Most of the educational work involved lecturing and mentoring students specializing in general practice (median 86 hours per year). Research output increased during the fellowship. Research topics were varied and relevant to the disciplinary field.
CONCLUSION: During the fellowship, the balancing, and even the reinforcement, of healthcare and research contributions were accompanied by a significant investment in educational provision.
BibTeX:
@article{Barais2018,
  author = {Barais, Marie and Laporte, Catherine and Schuers, Matthieu and Saint-Lary, Olivier and Frappé, Paul and Dibao-Dina, Clarisse and Darmon, David and Bouchez, Tiphanie and Gelly, Julien},
  title = {Cross-sectional multicentre study on the cohort of all the {French} junior lecturers in general practice},
  month = {December},
  journal = {The European Journal of General Practice},
  year = {2018},
  volume = {24},
  number = {1},
  pages = {99--105},
  doi = {10.1080/13814788.2017.1422176}
}

Abstract: Background: The Food and Drug Administration (FDA) in the United States and the European Medicines Agency (EMA) have recognized social media as a new data source to strengthen their activities regarding drug safety. Objective: Our objective in the ADR-PRISM project was to provide text mining and visualization tools to explore a corpus of posts extracted from social media. We evaluated this approach on a corpus of 21 million posts from five patient forums, and conducted a qualitative analysis of the data available on methylphenidate in this corpus. Methods: We applied text mining methods based on named entity recognition and relation extraction in the corpus, followed by signal detection using proportional reporting ratio (PRR). We also used topic modelling based on the Correlated Topic Model to obtain the list of thematics in the corpus and classify the messages based on their topics. Results: We automatically identified 3443 posts about methylphenidate published between 2007 and 2016, among which 61 adverse drug reactions (ADR) were automatically detected. Two pharmacovigilance experts evaluated manually the quality of automatic identification, and a f-measure of 0.57 was reached. Patient’s reports were mainly neuro-psychiatric effects. Applying PRR, 67% of the ADRs were signals, including most of the neuro-psychiatric symptoms but also palpitations. Topic modelling showed that the most represented topics were related to Childhood and Treatment initiation, but also Side effects. Cases of misuse were also identified in this corpus, including recreational use and abuse. Conclusion: Named entity recognition combined with signal detection and topic modelling have demonstrated their complementarity in mining social media data. An in-depth analysis focused on methylphenidate showed that this approach was able to detect potential signals and to provide better understanding of patients’ behaviors regarding drugs, including misuse.
BibTeX:
@article{Chen2018,
  author = {Chen, Xiaoyi and Faviez, Carole and Schuck, Stéphane and Lillo-Le-Louët, Agnès and Texier, Nathalie and Dahamna, Badisse and Huot, Charles and Foulquié, Pierre and Pereira, Suzanne and Leroux, Vincent and Karapetiantz, Pierre and Guenegou-Arnoux, Armelle and Katsahian, Sandrine and Bousquet, Cédric and Burgun, Anita},
  title = {Mining Patients' Narratives in Social Media for Pharmacovigilance: Adverse Effects and Misuse of Methylphenidate},
  journal = {Frontiers in Pharmacology},
  year = {2018},
  volume = {9},
  url = {https://www.frontiersin.org/articles/10.3389/fphar.2018.00541/full},
  doi = {10.3389/fphar.2018.00541}
}

Abstract: BACKGROUND: While documentation of clinical aspects of General Practice/Family Medicine (GP/FM) is assured by the International Classification of Primary Care (ICPC), there is no taxonomy for the professional aspects (context and management) of GP/FM. OBJECTIVES: To present the development, dissemination, applications, and resulting face validity of the Q-Codes taxonomy specifically designed to describe contextual features of GP/FM, proposed as an extension to the ICPC. DEVELOPMENT: The Q-Codes taxonomy was developed from Lamberts' seminal idea for indexing contextual content (1987) by a multi-disciplinary team of knowledge engineers, linguists and general practitioners, through a qualitative and iterative analysis of 1702 abstracts from six GP/FM conferences using Atlas.ti software. A total of 182 concepts, called Q-Codes, representing professional aspects of GP/FM were identified and organized in a taxonomy. Dissemination: The taxonomy is published as an online terminological resource, using semantic web techniques and web ontology language (OWL) ( http://www.hetop.eu/Q ). Each Q-Code is identified with a unique resource identifier (URI), and provided with preferred terms, and scope notes in ten languages (Portuguese, Spanish, English, French, Dutch, Korean, Vietnamese, Turkish, Georgian, German) and search filters for MEDLINE and web searches. APPLICATIONS: This taxonomy has already been used to support queries in bibliographic databases (e.g., MEDLINE), to facilitate indexing of grey literature in GP/FM as congress abstracts, master theses, websites and as an educational tool in vocational teaching, Conclusions: The rapidly growing list of practical applications provides face-validity for the usefulness of this freely available new terminological resource.
BibTeX:
@article{Jamoulle2018,
  author = {Jamoulle, Marc and Resnick, Melissa and Grosjean, Julien and Ittoo, Ashwin and Cardillo, Elena and Vander Stichele, Robert and Darmoni, Stefan and Vanmeerbeek, Marc},
  title = {Development, dissemination, and applications of a new terminological resource, the {Q}-{Code} taxonomy for professional aspects of general practice/family medicine},
  month = {December},
  journal = {The European journal of general practice},
  year = {2018},
  volume = {24},
  number = {1},
  pages = {68--73},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/29243572},
  doi = {10.1080/13814788.2017.1404986}
}

Abstract: PURPOSE: Microsurgical reconstruction in a vessel-depleted neck is a challenge due to the lack of reliable vessels in or nearby the host site. The use of the internal thoracic pedicle (ITP) by rib section or sparring is a limited option due to the small length of the pedicle of some flaps. However, in cardiac surgery, the internal thoracic artery (ITA) is widely used for myocardial revascularization, providing a long and versatile pedicle. We aimed at determining precise anatomical bases for the use of the ITP, approached by sternotomy and rerouted in the neck, as recipient vessels for free-flap facial reconstructions. METHODS: We performed a descriptive single centre anatomical study on 20 formalin-embalmed cadavers. The ITP was harvested on both sides from the emergence of the artery under the brachiocephalic vein to its terminal division. The level reached by the ITP in the cervicofacial area was described. Distal arterial and venous diameters, pedicle length and other parameters were measured. RESULTS: In at least 85% of the cases, the ITP reached the mandibular angle. The mean diameter at the distal extremity for the ITA was 2.36 ± 0.15, and 2.48 ± 0.19 mm for the committing vein. The mean length of the ITP was 177.3 mm. CONCLUSION: Rerouting the ITP towards the cervicofacial area could provide a reliable pedicle for free-flap reconstructions in patients with a vessel-depleted neck but it should be limited to selected patients. This novel solution for situations where current techniques are unfeasible warrants further clinical research.
BibTeX:
@article{Morel2018,
  author = {Morel, François and Crampon, Frédéric and Adnot, Jérôme and Litzler, Pierre-Yves and Duparc, Fabrice and Trost, Olivier},
  title = {Rerouting the internal thoracic pedicle: a novel solution for maxillofacial reconstruction in vessel-depleted situations? A preliminary anatomic study},
  month = {August},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2018},
  volume = {40},
  number = {8},
  pages = {911--916},
  doi = {10.1007/s00276-017-1965-1}
}

Abstract: BACKGROUND: Unstructured health documents (e.g. discharge summaries) represent an important and unavoidable source of information.
METHODS: A semantic annotator identified all the concepts present in the health documents from the clinical data warehouse of the Rouen University Hospital.
RESULTS: 2,087,784,055 annotations were generated from a corpus of about 11.9 million documents with an average of 175 annotations per document. SNOMED CT, NCIt and MeSH were the top 3 terminologies that reported the most annotation.
DISCUSSION: As expected, the most general terminologies with the most translated concepts were those with the most concepts identified.
BibTeX:
@article{Ndangang2018,
  author = {Ndangang, Marie and Grosjean, Julien and Lelong, Romain and Dahamna, Badisse and Kergourlay, Ivan and Griffon, Nicolas and Darmoni, Stéfan J.},
  title = {Terminology {Coverage} from {Semantic} {Annotated} {Health} {Documents}},
  journal = {Studies in Health Technology and Informatics},
  year = {2018},
  volume = {255},
  pages = {20--24},
  doi = {10.3233/978-1-61499-921-8-20}
}

Abstract: Background: Burnout is a common occurrence among GPs, decreasing quality of and access to care and impacting both physician and patient health. The link between burnout and low medical density has never been studied.
Objectives: This study aimed to assess the prevalence of burnout and its related factors, including low medical density, among GPs.
Method: We conducted a cross-sectional survey. A self-administered questionnaire was sent to all of the 1632 GPs in Normandy, France, in September 2015. The Maslach Burnout Inventory was used to assess the three burnout dimensions: emotional exhaustion (EE), depersonalization (DP) and low personal accomplishment (PA).
Results: In all, 501 GPs sent back their questionnaire (response rate: 30.7; 487 questionnaires were analysed. Burnout had been experienced by 43.3% of the physicians in the sample. Nearly 24% of the respondents scored high EE, 27.3% scored high DP, and 13.3% scored low PA. Low medical density [odds ratios (OR): 2.16 (1.31-3.54)], and intent to quit [OR: 4.40 (2.59-7.47)] were strongly linked to the three burnout dimensions. Burnout was not linked with quantitative workload.
Conclusion: Burnout among GPs was common. Low medical density and intent to quit were strong predictors of burnout. Given the current medical demographic crisis, these results highlight the relationship between burnout and medical shortage. Qualitative workload may have a more significant influence on burnout than quantitative workload. Recruiting more GPs is necessary, but may prove insufficient in fighting burnout. Preventive and curative actions are required, especially in areas with low medical density.
BibTeX:
@article{Picquendar2018,
  author = {Picquendar, Guillaume and Guedon, Antoine and Moulinet, Fanny and Schuers, Matthieu},
  title = {Influence of medical shortage on {GP} burnout: a cross-sectional study},
  month = {September},
  journal = {Family Practice},
  year = {2018},
  doi = {10.1093/fampra/cmy080}
}

Abstract: Objective
There is a growing interest in using natural language processing (NLP) for healthcare-associated infections (HAIs) monitoring. A French project consortium, SYNODOS, developed a NLP solution for detecting medical events in electronic medical records for epidemiological purposes. The objective of this study was to evaluate the performance of the SYNODOS data processing chain for detecting HAIs in clinical documents.
Materials and methods
The collection of textual records in these hospitals was carried out between October 2009 and December 2010 in three French University hospitals (Lyon, Rouen and Nice). The following medical specialties were included in the study: digestive surgery, neurosurgery, orthopedic surgery, adult intensive-care units. Reference Standard surveillance was compared with the results of automatic detection using NLP. Sensitivity on 56 HAI cases and specificity on 57 non-HAI cases were calculated.
Results
The accuracy rate was 84% (n = 95/113). The overall sensitivity of automatic detection of HAIs was 83.9% (CI 95 71.7–92.4) and the specificity was 84.2% (CI 95 72.1–92.5). The sensitivity varies from one specialty to the other, from 69.2% (CI 95 38.6–90.9) for intensive care to 93.3% (CI 95 68.1–99.8) for orthopedic surgery. The manual review of classification errors showed that the most frequent cause was an inaccurate temporal labeling of medical events, which is an important factor for HAI detection.
Conclusion
This study confirmed the feasibility of using NLP for the HAI detection in hospital facilities. Automatic HAI detection algorithms could offer better surveillance standardization for hospital comparisons.
BibTeX:
@article{Tvardik2018,
  author = {Tvardik, Nastassia and Kergourlay, Ivan and Bittar, André and Segond, Frédérique and Darmoni, Stefan and Metzger, Marie-Hélène},
  title = {Accuracy of using natural language processing methods for identifying healthcare-associated infections},
  month = {September},
  journal = {International Journal of Medical Informatics},
  year = {2018},
  volume = {117},
  pages = {96--102},
  url = {http://www.sciencedirect.com/science/article/pii/S1386505618304362},
  doi = {10.1016/j.ijmedinf.2018.06.002}
}

BibTeX:
@article{Lacroix-Hugues2018,
  author = {Lacroix-Hugues, V. and Schuers, M. and Pradier, C. and Staccini, P. and Letrilliart, L. and Darmon, D.},
  title = {Utilisation des enregistrements médicaux électroniques dans le cadre du projet {PRIMEGE} {PACA}},
  month = {May},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2018},
  number = {143},
  pages = {197--203},
  url = {https://www.lissa.fr/fr/rep/articles/AA_1015780242018143197203utilla}
}

Abstract: Les infections urinaires masculines (IUM) sont un continuum allant des formes cliniques paucisymptomatiques (« cystite-like » dans la littérature anglo-saxonne) à la prostatite et à l’urosepsis sévère. La bandelette urinaire positive pour leucocytes et/ou nitrites conforte la suspicion clinique mais ne dispense pas de l’examen cytobactériologique des urines. En présence de fièvre, d’une mauvaise tolérance, d’une rétention aiguë d’urine, le traitement doit être introduit sans tarder. Les IUM paucisymptomatiques doivent être documentées et les patients réévalués. Le caractère fruste
permet de décaler si possible l’introduction d’une antibiothérapie. La ciprofloxacine et la lévofloxacine sont les traitements de référence pour une durée de 14 jours quelle que soit l’intensité de l’IUM. L’ofloxacine ne doit plus être prescrite de façon probabiliste en raison d’une augmentation des résistances en soins premiers.
BibTeX:
@article{Soudais2018,
  author = {Soudais, B and Schuers, M and Lefebvre, E and Etienne, M and Pellerin, L},
  title = {Infections urinaires masculines en soins primaires},
  month = {October},
  journal = {exercer, la revue française de médecine générale},
  year = {2018},
  number = {146},
  pages = {368--73},
  url = {https://www.exercer.fr/numero/146/page/368/}
}

BibTeX:
@inproceedings{Douze2018,
  author = {Douze, L and Kerdelhue, G and Grosjean, J and Schiro, J and Pelayo, S and Marcilly, R},
  title = {Search engines in medicine: the need to involve healthcare professional end users},
  booktitle = {MIE},
  year = {2018}
}

BibTeX:
@inproceedings{Lelong2018,
  author = {Romain Lelong and Lina F. Soualmia and Saoussen Sakji and Badisse Dahamna and Stéfan Darmoni},
  title = {NoSQL technology in order to support Semantic Health Search Engine},
  booktitle = {MIE 2018},
  year = {2018}
}

Abstract: La base de données bibliographiques LiSSa (Littérature scientifique en santé) (www.lissa.fr) référence plus d'un million d'articles francophones et vise à les rendre plus visibles à l'heure où la place de la langue française pour ces publications est de plus en plus discutée. La base a été créée à l'aide de multiples sources de données publiques et privées et la contribution de plusieurs éditeurs. Le moteur de recherche peut être interrogé simplement et apporter des résultats pertinents. Un formulaire de recherche avancée et des options spécifiques permettent également de mener des recherches plus complexes. Des fonctionnalités d'exportations et d'alertes sont également disponibles pour manipuler facilement les références et être tenu informé.
BibTeX:
@article{Kerdelhue2018,
  author = {Gaétan Kerdelhué and Jean-Francois Gehanno and Julien Grosjean and Stéfan Darmoni},
  title = {La base de données bibliographiques LiSSa (Littérature scientifique en santé) : intérêt et utilisation pour la santé au travail},
  journal = {Références en Santé au Travail},
  year = {2018},
  number = {154},
  pages = {115-119},
  url = {http://www.rst-sante-travail.fr/rst/pages-article/ArticleRST.html?ref=RST.TM%2046}
}

2017


Abstract: The purpose of this anatomic study was to compare the retraction force necessary to expose the mandibular neck in the Risdon and the high cervical anteroparotid transmasseteric (HAT) approaches. An anatomic study was performed on 18 formalin-embalmed cadavers. We performed a Risdon approach on the left side, and an HAT approach on the right side in all the cases. The subjects were placed in a normative frame and the force necessary to maintain a satisfactory exposure of the condyle was measured with a system of cables, pulleys, and mechanical dynamometer. The statistical comparison between the two sides was carried out using the Wilcoxon signed-rank test for paired series. In all the cases, the region of interest was exposed as in the operating room. In the Risdon approach, the mean force was 32 Newtons (4-47). In the HAT approach, the mean force was 19 Newtons (4-33). The difference was statistically significant (p < 0.001). The age, gender, and duration of conservation had no influence on the retraction force. In the HAT approach, the retraction of the soft tissues was significantly lower than in the Risdon approach. This study gave an additional explanation to the remarkable safety of the HAT approach. Our results were in favor of the generalization of this technique.
BibTeX:
@article{Adnot2017,
  author = {Adnot, Jérôme and Feuss, Aliosha and Duparc, Fabrice and Trost, Olivier},
  title = {Retraction force necessary to expose the mandibular neck in Risdon and high cervical anteroparotid transmasseteric approaches: an anatomic comparative study.},
  month = {April},
  journal = {Surgical and radiologic anatomy : SRA},
  year = {2017},
  doi = {10.1007/s00276-017-1853-8}
}

Abstract: The authors report the case of a 43-year-old woman who underwent endodontic treatment of the right second mandibular molar with substantial extrusion of endodontic material into the mandibular canal. The patient presented at the Department of Oral and Maxillofacial Surgery with a persistent total anaesthesia of the lower lip and chin after two months. 2D panoramic view and 3D CT-scan examination highlighted the overfilling into the mandibular canal with a more than 50% stenosis of the canal and a consequently significant compression of the dental pedicle. A surgical decompression of the inferior alveolar nerve was performed through an inferior vestibular approach, using PiezoSurgery®. The tooth was conserved. After a period of 8days, paraesthesia of the lower lip and chin appeared. Thermoalgic sensitivity was recovered at 1month. At 3months postoperatively, the patient had recovered protopathic and epicritic sensitivity. Dental prosthetic rehabilitation was finally achieved one year postoperatively. The authors discuss the physiopathology of nervous injuries during dental procedures, and further strategies in the case of persistent neurologic disorders.
BibTeX:
@article{Bastien2017,
  author = {Bastien, A.-V. and Adnot, J. and Moizan, H. and Calenda, É. and Trost, O.},
  title = {Secondary surgical decompression of the inferior alveolar nerve after overfilling of endodontic sealer into the mandibular canal: Case report and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2017},
  volume = {118},
  number = {6},
  pages = {389--392},
  doi = {10.1016/j.jormas.2017.09.001}
}

Abstract: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Classical Pharmacovigilance process is limited by underreporting which justifies the current interest in new knowledge sources such as social media. The Adverse Drug Reactions from Patient Reports in Social Media (ADR-PRISM) project aims to extract ADRs reported by patients in these media. We identified 5 major challenges to overcome to operationalize the analysis of patient posts: (1) variable quality of information on social media, (2) guarantee of data privacy, (3) response to pharmacovigilance expert expectations, (4) identification of relevant information within Web pages, and (5) robust and evolutive architecture. This article aims to describe the current state of advancement of the ADR-PRISM project by focusing on the solutions we have chosen to address these 5 major challenges. In this article, we propose methods and describe the advancement of this project on several aspects: (1) a quality driven approach for selecting relevant social media for the extraction of knowledge on potential ADRs, (2) an assessment of ethical issues and French regulation for the analysis of data on social media, (3) an analysis of pharmacovigilance expert requirements when reviewing patient posts on the Internet, (4) an extraction method based on natural language processing, pattern based matching, and selection of relevant medical concepts in reference terminologies, and (5) specifications of a component-based architecture for the monitoring system. Considering the 5 major challenges, we (1) selected a set of 21 validated criteria for selecting social media to support the extraction of potential ADRs, (2) proposed solutions to guarantee data privacy of patients posting on Internet, (3) took into account pharmacovigilance expert requirements with use case diagrams and scenarios, (4) built domain-specific knowledge resources embeding a lexicon, morphological rules, context rules, semantic rules, syntactic rules, and post-analysis processing, and (5) proposed a component-based architecture that allows storage of big data and accessibility to third-party applications through Web services. We demonstrated the feasibility of implementing a component-based architecture that allows collection of patient posts on the Internet, near real-time processing of those posts including annotation, and storage in big data structures. In the next steps, we will evaluate the posts identified by the system in social media to clarify the interest and relevance of such approach to improve conventional pharmacovigilance processes based on spontaneous reporting.
BibTeX:
@article{Bousquet2017,
  author = {Bousquet, Cedric and Dahamna, Badisse and Guillemin-Lanne, Sylvie and Darmoni, Stefan J and Faviez, Carole and Huot, Charles and Katsahian, Sandrine and Leroux, Vincent and Pereira, Suzanne and Richard, Christophe and Schück, Stéphane and Souvignet, Julien and Lillo-Le Louët, Agnès and Texier, Nathalie},
  title = {The Adverse Drug Reactions from Patient Reports in Social Media Project: Five Major Challenges to Overcome to Operationalize Analysis and Efficiently Support Pharmacovigilance Process.},
  month = {September},
  journal = {JMIR research protocols},
  year = {2017},
  volume = {6},
  pages = {e179},
  doi = {10.2196/resprot.6463}
}

Abstract: Introduction
In January 2015, Rouen University Hospital’s information system experienced serious issues. It was necessary to rapidly switch from the computerized provider order entry (CPOE) system towards a paper-based order entry (PBOE) system. This was an opportunity to evaluate prescriber opinion on the two provider order entry (POE) systems.
Methods
All residents were asked to fill an augmented version of the POE satisfaction and usage survey for both POE systems. The results were compared to identify the strengths and weaknesses of each system.
Results
Fifty-one respondents had used the CPOE system and the PBOE system. Overall, satisfaction was higher with PBOE than CPOE (odds ratio (OR) = 3.74; p < 0.001). Usability (OR = 4.00; p < 0.001), reliability (OR = 8.54; p < 0.001), time consumption (OR = 0.50; p < 0.05 – survey statement was formulated negatively), and communication with nurses (OR = 14.27; p < 0.0001) reached statistically better agreement. The more experience with CPOE the more residents were disillusioned with the reliability (OR = 6.55; p < 0.01), the usability (OR = 5.68; p < 0.01) and the patient safety (OR = 0.27; p < 0.05 – survey statement was formulated negatively) of CPOE. Although safety issues were reported for both systems, the causes were different; PBOE imposed frequent rewriting of the order while CPOE lack of usability might be unsafe. Another important issue with both POE systems was time consumption.
Conclusion
Residents did not report any increase in safety issues with the rapid switch from CPOE to PBOE. They even seemed more satisfied with the rollback to paper, which remains a possible degraded mode in case of health information technology collapse.
BibTeX:
@article{Griffon2017,
  author = {Griffon, N. and Schuers, M. and Joulakian, M. and Bubenheim, M. and Leroy, J.-P. and Darmoni, S. J.},
  title = {Physician satisfaction with transition from {CPOE} to paper-based prescription},
  month = {July},
  journal = {International Journal of Medical Informatics},
  year = {2017},
  volume = {103},
  pages = {42--48},
  url = {http://www.ijmijournal.com/article/S1386-5056(17)30085-0/abstract},
  doi = {10.1016/j.ijmedinf.2017.04.007}
}

Abstract: This case control study assessed: the relationship of systemic sclerosis (SSc) related to exposure to heavy metals, the risk of SSc related to occupational exposure in male and female patients. From 2005 to 2008, 100 patients with a definite diagnosis of SSc were included in the study; 3 age, gender, and smoking habits matched controls were selected for each patient. All SSc patients and controls underwent detection and quantification of heavy metal traces in hair samples, using multi-element inductively coupled plasma mass spectrometry (ICP-MS). SSc patients exhibited higher median levels of the following metals: antimony (p=0.001), cadmium (p=0.0003), lead (p=0.02), mercury (p=0.02), molybdenum (p=0.04), palladium (p<0.001) and zinc (p=0.0003). A marked association between SSc and occupational exposure was further found for: 1) antimony (p=0.008) and platinum (p=0.04) in male patients; and 2) antimony (p=0.02), cadmium (p=0.001), lead (p=0.03), mercury (p=0.03), palladium (p=0.0003) and zinc (p=0.0001) in female patients CONCLUSION: The results show the impact of occupational risk factors in the development of SSc for: antimony, cadmium, lead, mercury, molybdenum, palladium and zinc. Thus, occupational exposure should be systematically checked in all SSc patients at diagnosis. Finally, the association between SSc and occupational exposure may be variable according to patients" gender.
BibTeX:
@article{Marie2017,
  author = {Marie, I and Gehanno, J-F and Bubenheim, M and Duval-Modeste, A-B and Joly, P and Dominique, S and Bravard, P and Noël, D and Cailleux, A-F and Weber, J and Lagoutte, P and Benichou, J and Levesque, H and Goullé, J-P},
  title = {Systemic sclerosis and exposure to heavy metals: A case control study of 100 patients and 300 controls.},
  month = {January},
  journal = {Autoimmunity reviews},
  year = {2017},
  doi = {10.1016/j.autrev.2017.01.004}
}

Abstract: MEDLINE is the most widely used medical bibliographic database in the world. Most of its citations are in English and this can be an obstacle for some researchers to access the information the database contains. We created a multilingual query builder to facilitate access to the PubMed subset using a language other than English. The aim of our study was to assess the impact of this multilingual query builder on the quality of PubMed queries for non-native English speaking physicians and medical researchers. A randomised controlled study was conducted among French speaking general practice residents. We designed a multi-lingual query builder to facilitate information retrieval, based on available MeSH translations and providing users with both an interface and a controlled vocabulary in their own language. Participating residents were randomly allocated either the French or the English version of the query builder. They were asked to translate 12 short medical questions into MeSH queries. The main outcome was the quality of the query. Two librarians blind to the arm independently evaluated each query, using a modified published classification that differentiated eight types of errors. Twenty residents used the French version of the query builder and 22 used the English version. 492 queries were analysed. There were significantly more perfect queries in the French group vs. the English group (respectively 37.9% vs. 17.9%; p < 0.01). It took significantly more time for the members of the English group than the members of the French group to build each query, respectively 194 sec vs. 128 sec; p < 0.01. This multi-lingual query builder is an effective tool to improve the quality of PubMed queries in particular for researchers whose first language is not English.
BibTeX:
@article{Schuers2017,
  author = {Schuers, Matthieu and Joulakian, Mher and Kerdelhué, Gaetan and Segas, Léa and Grosjean, Julien and Darmoni, Stéfan J and Griffon, Nicolas},
  title = {Lost in translation? A multilingual Query Builder improves the quality of PubMed queries: a randomised controlled trial.},
  month = {July},
  journal = {BMC medical informatics and decision making},
  year = {2017},
  volume = {17},
  pages = {94},
  doi = {10.1186/s12911-017-0490-9}
}

Abstract: Metopism (complete persistence of the metopic suture in adults) is a rare but not exceptional variation of the calvaria. Hypoplasia or aplasia of the frontal sinus may be associated without evident correlation. Nevertheless, a misdiagnosis of these variations may have clinical consequences, especially in a traumatic context. The aim of this paper was to report a case of metopism associated with a unilateral aplasia of the left frontal sinus, originally illustrated with 3D image fusion volume rendering reconstructions.
BibTeX:
@article{Eliezer2017,
  author = {Eliezer, M. and Crampon, F. and Adnot, J. and Duparc, F. and Trost, O.},
  title = {Représentation tridimensionnelle originale d’un cas de métopisme associé à une agénésie unilatérale complète du sinus frontal gauche : intérêt clinique et revue de la littérature},
  month = {May},
  journal = {Morphologie: Bulletin De l'Association Des Anatomistes},
  year = {2017},
  doi = {10.1016/j.morpho.2017.04.004}
}

Abstract: Introduction Les publications scientifiques en français sont de plus en plus éclipsées par les publications en langue anglaise, notamment dans les bases de données bibliographiques internationales. Il s’agit pourtant de ressources potentiellement utiles pour beaucoup de professionnels médicaux et paramédicaux. Objectifs L’objectif de cet article est de présenter un nouvel outil, LiSSa pour « Littérature Scientifique en Santé », qui vise à agréger l’ensemble de la littérature médicale en français, ainsi que les premières étapes de sa conception. Méthodes L’agrégation de différentes bases de données requiert l’harmonisation des métadonnées et l’adaptation du modèle de données. Une évaluation ergonomique préliminaire a été réalisée. Résultats Les données de PubMed et d’Elsevier-Masson ont été intégrées, permettant la mise à disposition d’une base de données bibliographique riche de 869 834 références. Concernant les données postérieures à 2000, LiSSa regroupe 300 988 références, dont 81 239 avec le résumé en français et 209 610 avec un lien vers le texte intégral (dont 15 838 en accès gratuit). L’évaluation ergonomique a confirmé l’intérêt des professionnels de santé pour cet outil et a permis d’aboutir à l’actuelle version de LiSSa qui dispose d’outils de filtre et d’exportation classiques pour ce genre d’outil, ainsi que de liens contextuels vers PubMed et vers le Catalogue et Index des Sites Médicaux en langue Française. Conclusion : LiSSa est gratuitement disponible à l’URL suivante: http://www.lissa.fr .
BibTeX:
@article{Griffon2017a,
  author = {Griffon, N. and Rollin, L. and Schuers, M. and Douze, L. and Rodriguez, D. and Delerue, D. and Dutoit, D. and Dahamna, B. and Kerdelhué, G. and Grosjean, J. and Gehanno, JF. and Darmoni, SJ.},
  title = {{LiSSa}, {Littérature} {Scientifique} en {Santé} : une base de données bibliographique en français},
  journal = {Pratique Neurologique - FMC},
  year = {2017},
  volume = {8},
  number = {4},
  pages = {204-247},
  doi = {10.1016/j.praneu.2017.06.008}
}

BibTeX:
@article{Griffon2016c,
  author = {Griffon, Nicolas and Schuers, Matthieu and Kerdelhué, Gaétan and Grosjean, Julien and Darmoni, Stéfan},
  title = {Littérature scientifique en santé ({LiSSa}) : une base de données bibliographiques en français},
  journal = {La Revue Du Praticien},
  year = {2017},
  volume = {67},
  number = {2},
  pages = {134-138}
}

Abstract: Les médecins généralistes sont désormais encouragés à pratiquer une médecine fondée sur les preuves ou evidence-based medicine (EBM). Cela consiste à combiner son expertise clinique aux données de la science, en tenant compte de la situation de soins et en intégrant les valeurs et les attentes du patient aux propositions qui lui seront faites. Beaucoup de données actualisées des connaissances médicales sont aujourd’hui accessibles par Internet. Il existe pourtant des freins à la recherche efficiente d’information médicale en ligne par le généraliste : le manque de temps ou de repères dans la navigation sur Internet ou la quantité trop importante d’informations à analyser.
BibTeX:
@article{Schuers2017b,
  author = {Matthieu Schuers and Nicolas Griffon and Gaëtan Kerdelhué and Quentin Foubert and Alain Mercier and Stéfan Darmoni},
  title = {Comportement des internes et des généralistes dans la recherche d'informations de santé : de l'intention à la pratique},
  journal = {Exercer},
  year = {2017},
  number = {132},
  pages = {170-171},
  url = {https://www.exercer.fr/full_article/867}
}

BibTeX:
@article{Siedlecki2017,
  author = {Siedlecki, C. and Griffon, N. and Kerdelhué, G.},
  title = {Thèmes et tendances des publications en médecine générale dans {PubMed}},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2017},
  number = {130},
  pages = {70--1},
  url = {https://www.exercer.fr/full_article/848}
}

Abstract: Extracting concepts from medical texts is a key to support many advanced applications in medical information retrieval. Entity recognition in French texts is moreover challenged by the availability of many resources originally developed for English texts. This paper proposes an evaluation of the terminology coverage in a corpus of 50,000 French articles extracted from the bibliographic database LiSSa. This corpus was automatically indexed with 32 health terminologies, published in French or translated. Then, the terminologies providing the best coverage of these documents were determined. The results show that major resources such as the NCI and SNOMED CT thesauri achieve the largest annotation of the corpus while specific French resources prove to be valuable assets.
BibTeX:
@article{Cabot2017,
  author = {Cabot, Chloé and Soualmia, Lina F and Grosjean, Julien and Griffon, Nicolas and Darmoni, Stéfan J},
  title = {Evaluation of the Terminology Coverage in the French Corpus LiSSa.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {126--130},
  doi = {10.3233/978-1-61499-753-5-126}
}

BibTeX:
@inproceedings{Chebil2017,
  author = {Wiem Chebil and Lina Fatima Soualmia and Mohamed Nazih Omri and St{\'{e}}fan Jacques Darmoni},
  title = {Indexing biomedical documents with Bayesian networks and terminologies},
  booktitle = {12th International Conference on Intelligent Systems and Knowledge Engineering, {ISKE} 2017, Nanjing, China, November 24-26, 2017},
  year = {2017},
  pages = {1--6},
  url = {https://doi.org/10.1109/ISKE.2017.8258745},
  doi = {10.1109/ISKE.2017.8258745}
}

Abstract: Suspected adverse drug reactions (ADR) reported by patients through social media can be a complementary source to current pharmacovigilance systems. However, the performance of text mining tools applied to social media to discover ADRs needs to be evaluated. In this paper, we introduce the approach developed to mine ADR from French social media. A protocol of evaluation is highlighted, which includes a detailed sample size determination and corpus constitution. Our text mining approach provided very encouraging preliminary results with F-measures of 0.94, 0.81 and 0.70 for recognition of drugs, symptoms and ADRs respectively, thus this approach is promising for downstream pharmacovigilance analysis.
BibTeX:
@inproceedings{Chen2017,
  author = {Chen, C and Deldossi, M and Aboukhamis, R and Faviez, C and Dahamna, B and Karapetiantz, P and Guenegou-Arnoux, A and Girardeau, Y and Guillemin-Lanne, S and Lillo-Le-Louët, A and Texier, N and Burgun, A and Katsahian, S},
  title = {Mining adverse drug reactions in social media with named entity recognition and semantic methods},
  booktitle = {Medinfo},
  year = {2017},
  note = {Accepted}
}

Abstract: The hereby proposed terminology called "Q-Codes" can be defined as an extension of the International Classification of Primary Care (ICPC-2). It deals with non-clinical concepts that are relevant in General Practice/Family Medicine (GP/FM). This terminology is a good way to put an emphasis on underestimated topics such as Teaching, Patient issues or Ethics. It aims at indexing GP/FM documents such as congress abstracts and theses to get a more comprehensive view about the GP/FM domain. The 182 identified Q-Codes have been very precisely defined by a college of experts (physicians and terminologists) from twelve countries. The result is available on the Health Terminology/Ontology Portal (http://www.hetop.org/Q) and formatted in OWL-2 for further semantic considerations and will be used to index the 2016 WONCA World congress communications.
BibTeX:
@article{Jamoulle2017,
  author = {Jamoulle, Marc and Grosjean, Julien and Resnick, Melissa and Ittoo, Ashwin and Treuherz, Arthur and Vander Stichele, Robert and Cardillo, Elena and Darmoni, Stéfan J and Shamenek, Frank S and Vanmeerbeek, Marc},
  title = {A Terminology in General Practice/Family Medicine to Represent Non-Clinical Aspects for Various Usages: The Q-Codes.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {471--475}
}

BibTeX:
@inproceedings{Jamoulle2017a,
  author = {Jamoulle, Marc and Resnick, Melissa and Ittoo, Ashwin and Vander Stichele, Robert and Cardillo, Elena and Grosjean, Julien and Darmoni, Stefan and Vanmeerbeek, Marc},
  title = {Indexing grey multilingual literature in {General} {Practice} in the era of {Semantic} {Web}},
  booktitle = {Nineteenth International Conference on Grey Literature Public Awareness and Access to Grey Literature},
  address = {Rome, Italy},
  month = {October},
  journal = {The Grey Journal},
  year = {2017},
  url = {https://orbi.uliege.be/handle/2268/210490}
}

Abstract: While the digitization of medical documents has greatly expanded during the past decade, health information retrieval has become a great challenge to address many issues in medical research. Information retrieval in electronic health records (EHR) should also reduce the difficult tasks of manual information retrieval from records in paper format or computer. The aim of this article was to present the features of a semantic search engine implemented in EHRs. A flexible, scalable and entity-oriented query language tool is proposed. The program is designed to retrieve and visualize data which can support any Conceptual Data Model. The search engine deals with structured and unstructured data, for a sole patient from a caregiver perspective, and for a number of patients (e.g. epidemiology). Several types of queries on a test database containing 2,000 anonymized patients EHRs (i.e. approximately 200,000 records) were tested. These queries were able to accurately treat symbolic, textual, numerical and chronological data.
BibTeX:
@article{Lelong2017,
  author = {Lelong, Romain and Soualmia, Lina and Dahamna, Badisse and Griffon, Nicolas and Darmoni, Stéfan J},
  title = {Querying EHRs with a Semantic and Entity-Oriented Query Language.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {121--125},
  doi = {10.3233/978-1-61499-753-5-121}
}

Abstract: The emergence of electronic health records has highlighted the need for semantic standards for representation of observations in laboratory medicine. Two such standards are LOINC, with a focus on detailed encoding of lab tests, and SNOMED CT, which is more general, including the representation of qualitative and ordinal test results. In this paper we will discuss how lab observation entries can be represented using SNOMED CT. We use resources provided by the Regenstrief Institute and SNOMED International collaboration, which formalize LOINC terms as SNOMED CT post-coordinated expressions. We demonstrate the benefits brought by SNOMED CT to classify lab tests. We then propose a SNOMED CT based model for lab observation entries aligned with the BioTopLite2 (BTL2) upper level ontology. We provide examples showing how a model designed with no ontological foundation can produce misleading interpretations of inferred observation results. Our solution based on a BTL2 conformant formal interpretation of SNOMED CT concepts allows representing lab test without creating unintended models. We argue in favour of an ontologically explicit bridge between compositional clinical terminologies, in order to safely use their formal representations in intelligent systems.
BibTeX:
@inproceedings{Mary2017,
  author = {Mary, Mélissa and Soualmia, Lina F. and Gansel, Xavier and Darmoni, Stéfan and Karlsson, Daniel and Schulz, Stefan},
  title = {Ontological {Representation} of {Laboratory} {Test} {Observables}: {Challenges} and {Perspectives} in the {SNOMED} {CT} {Observable} {Entity} {Model} {Adoption}},
  booktitle = {Artificial {Intelligence} in {Medicine}},
  month = {June},
  publisher = {Springer, Cham},
  year = {2017},
  series = {Lecture {Notes} in {Computer} {Science}},
  pages = {14--23},
  url = {https://link.springer.com/chapter/10.1007/978-3-319-59758-4_2},
  doi = {10.1007/978-3-319-59758-4_2}
}

BibTeX:
@inproceedings{Merabti2017,
  author = {Merabti, T and Grosjean, J and Darmoni, SJ},
  title = {MT@HeTOP: The Mapping and Translation tool based on the Health multi-terminology portal HeTOP},
  booktitle = {ISHIC2017 2nd International Saudi Health Informatics Conference},
  address = {Riyadh, Kingdom of Saudi of Arabia},
  month = {March},
  year = {2017}
}

BibTeX:
@inproceedings{Lelong2017a,
  author = {Romain Lelong and Lina Soualmia and Saoussen Sakji and Badisse Dahamna and Stéfan Darmoni},
  title = {Une technologie NoSQL au service de moteur de recherche en Santé},
  booktitle = {4ème édition du Symposium sur l'Ingénierie de l'Information Médicale},
  address = {Toulouse},
  month = {Novembre},
  year = {2017}
}

BibTeX:
@inproceedings{Charlet2017,
  author = {Charlet, Jean and Darmoni, St{\'e}fan J.},
  title = {{Formalisation et structure des terminologies en sant{\'e} ; ou plut{\^o}t, {\`a} quoi et comment cela sert ?}},
  booktitle = {{1er forum franco-qu{\'e}becois d'innovation en sant{\'e}}},
  address = {Montr{\'e}al, Unknown Region},
  year = {2017},
  note = {INVITED},
  url = {https://hal.archives-ouvertes.fr/hal-03762173}
}

BibTeX:
@inproceedings{Darmoni2017,
  author = {Darmoni, St{\'e}fan J. and Charlet, Jean and Boudy, J{\'e}r{\^o}me},
  title = {{Quelques nouveaut{\'e}s du domaine de la E-Sant{\'e}}},
  booktitle = {{9^e journ{\'e}e annuelle ITS}},
  address = {Lyon, France},
  year = {2017},
  note = {INVITED},
  url = {https://hal.archives-ouvertes.fr/hal-03762170}
}

BibTeX:
@article{Perrin2017,
  author = {Helene Perrin and Marion Denorme and Julien Grosjean and OMICtools community and Emeric Dynomant and Vincent J. Henry and Fabien Pichon and Stefan Darmoni and Arnaud Desfeux and Bruno J. Gonzalez},
  title = {OMICtools: a community-driven search engine for biological data analysis},
  journal = {CoRR},
  year = {2017},
  volume = {abs/1707.03659},
  url = {http://arxiv.org/abs/1707.03659}
}

BibTeX:
@phdthesis{Cabot2017a,
  author = {Chloé Cabot},
  title = {Recherche d'information clinomique au sein du Dossier Patient Informatisé : modélisation, implantation et évaluation},
  school = {Université de Rouen},
  year = {2017}
}

Abstract: La centralisation des données patients au sein de répertoires numériques soulève des problématiques d’interopérabilité avec les différents systèmes d’information médicaux tels que ceux utilisés en clinique, à la pharmacie ou dans les laboratoires d’analyse. Les instances de santé publique, en charge de développer et de déployer ces dossiers, recommandent l’utilisation de standards pour structurer (syntaxe) et coder l’information (sémantique). Pour les données du diagnostic in vitro (DIV) deux standards sémantiques sont largement préconisés : - la terminologie LOINC® (Logical Observation Identifier Names and Codes) pour représenter les tests de laboratoire ;- l’ontologie SNOMED CT® (Systematized Nomenclature Of MEDicine Clinical Terms) pour exprimer les résultats observés.Ce travail de thèse s’articule autour des problématiques d’interopérabilité sémantique en microbiologie clinique avec deux axes principaux : Comment aligner un Système Organisé de Connaissances du DIV en microbiologie avec l’ontologie SNOMED CT® ? Pour répondre à cet objectif j’ai pris le parti dans mon travail de thèse de développer des méthodologies d’alignement adaptées aux données du diagnostic in vitro plutôt que de proposer une méthode spécifique à l’ontologie SNOMED CT®. Les méthodes usuelles pour l’alignement d’ontologies ont été évaluées sur un alignement de référence entreLOINC® et SNOMED CT®. Les plus pertinentes sont implémentées dans une librairie R, qui sert de point de départ pour créer de nouveaux alignements au sein de bioMérieux. Quels sont les bénéfices et limites d’une représentation formelle des connaissances du DIV ? Pour répondre à cet objectif je me suis intéressée à la formalisation du couple (Observation) au sein d’un compte-rendu de laboratoire. J’ai proposé un formalisme logique pour représenter les tests de la terminologie LOINC® qui a permis de montrer les bénéfices d’une représentation ontologique pour classer et requêter les tests. Dans un second temps, j’ai formalisé un patron d’observations compatible avec l’ontologie SNOMED CT® et aligné sur lesconcepts de la top-ontologie BioTopLite2. Enfin, le patron d’observation a été évaluée afin d’être utilisé au sein des systèmes d’aide à la décision en microbiologie clinique. Pour résumer, ma thèse s’inscrit dans une dynamique de partage et réutilisation des données patients. Les problématiques d’interopérabilité sémantique et de formalisation des connaissances dans le domaine du diagnostic in vitro freinent aujourd’hui encore le développement de systèmes experts. Mes travaux de recherche ont permis de lever certains de ces verrous et pourront être réutilisés dans de nouveaux systèmes intelligents en microbiologie clinique afin de surveiller par exemple l’émergence de bactéries multi-résistantes, et adapter en conséquence des thérapies antibiotiques.
BibTeX:
@phdthesis{Mary2017a,
  author = {Mélissa Mary},
  title = {Interopérabilité sémantique en diagnostic in vitro : représentation des connaissances et alignements avec des terminologies biomédicales},
  school = {Université de Normandie},
  year = {2017},
  url = {http://www.theses.fr/2017NORMR033}
}

Abstract: Les médecins, et en particulier les médecins généralistes, sont confrontésquotidiennement à la difficulté de ne pas tout savoir. En médecine générale, l’étendue duchamp d’activité impose aux professionnels une maîtrise de plus en plus aiguë del’information, qui doit s’appuyer sur le développement d’une littératie numérique, c’està-dire la capacité d’utiliser et de comprendre les outils et médias numériques. Lesobjectifs de ce travail étaient d’identifier les obstacles à la recherche d’information chezles médecins généralistes et de développer et d’évaluer des outils susceptibles desurmonter ces difficultés.Pour cela, nous avons réalisé une étude qualitative auprès d’internes de médecinegénérale et de médecins généralistes français. Elle a permis de mettre en évidence denombreux obstacles à la recherche d’informations en santé en ligne. Ces obstaclesconcernent les professionnels et les outils, certains sont également d’ordre institutionnel.Parmi ces obstacles figure la langue anglaise, qui semble constituer un repoussoir pourles médecins installés mais également pour les médecins en formation. D’après lesdonnées que nous avons recueillies, ce frein concerne aussi bien l’information en ellemêmeque son support.Plusieurs des outils développés par l’équipe du Département d’Informatique etd’Information Médicales du CHU de Rouen ont vocation à répondre à ces difficultés. Labase de données bibliographiques LiSSa permet l’accès à plusieurs centaines de milliersde références francophones en santé, issues de PubMed mais également de revuesfrancophones non indexées dans PubMed. Le constructeur de requêtes bibliographiquesmédicales permet à des utilisateurs non anglophones de construire des équations derecherche complexes dans leur langue maternelle, leur permettant de requêter dansPubMed, LiSSa ou CISMeF
BibTeX:
@phdthesis{Schuers2017a,
  author = {Matthieu Schuers},
  title = {Évaluation d'outils d'accès à la connaissance en médecine générale},
  school = {université de Normandie},
  year = {2017},
  url = {https://tel.archives-ouvertes.fr/tel-01887674/}
}

2016


BibTeX:
@article{Bouvry2016,
  author = {Bouvry, C. and Tvardik, N. and Kergourlay, I. and Bittar, A. and Arnod-Prin, P. and Segond, F. and Dini, L. and Darmoni, S. and Metzger, M.H.},
  title = {The {SYNODOS} {Project}: {System} for the {Normalization} and {Organization} of {Textual} {Medical} {Data} for {Observation} in {Healthcare}},
  month = {April},
  journal = {IRBM},
  year = {2016},
  volume = {37},
  number = {2},
  pages = {109--115},
  url = {http://linkinghub.elsevier.com/retrieve/pii/S1959031816300045},
  doi = {10.1016/j.irbm.2016.03.002}
}

Abstract: In this article, we propose a new approach for indexing biomedical
documents based on a possibilistic network that carries out partial
matching between documents and biomedical vocabulary. The main contribution
of our approach is to deal with the imprecision and uncertainty of
the indexing task using possibility theory. We enhance estimation
of the similarity between a document and a given concept using the
two measures of possibility and necessity. Possibility estimates
the extent to which a document is not similar to the concept. The
second measure can provide confirmation that the document is similar
to the concept. Our contribution also reduces the limitation of partial
matching. Although the latter allows extracting from the document
other variants of terms than those in dictionaries, it also generates
irrelevant information. Our objective is to filter the index using
the knowledge provided by the Unified Medical Language System®. Experiments
were carried out on different corpora, showing encouraging results
(the improvement rate is +26.37% in terms of main average precision
when compared with the baseline).
BibTeX:
@article{Chebil2014,
  author = {Chebil, Wiem and Soualmia, Lina Fatima and Omri, Mohamed Nazih and Darmoni, Stéfan Jacques},
  title = {Indexing biomedical documents with a possibilistic network},
  month = {April},
  journal = {Journal of the Association for Information Science and Technology},
  year = {2016},
  volume = {67},
  number = {4},
  pages = {928-941},
  url = {http://onlinelibrary.wiley.com/doi/10.1002/asi.23435/abstract},
  doi = {10.1002/asi.23435}
}

Abstract: BACKGROUND: Health care workers (HCWs) are considered to be at higher
risk of tuberculosis (TB) than the general population. However, a
decreasing incidence in the general population as well as improvement
in preventive measures in hospitals has reduced the risk for HCWs.
AIMS: To quantify the actual incidence of TB in nurses and health
care assistants in a low-incidence country. METHODS: We performed
a retrospective study of 80 hospitals throughout France, employing
233389 health care staff (physicians excluded). We calculated the
number of pulmonary TB cases over 3 years (700166 person-years) and
the total number of staff members in each job category (nurses, health
care assistants, administrative staff) in each hospital, to calculate
the incidence. RESULTS: Overall, the incidence rate varied between
1.27 and 6/100000 for administrative staff and nurses, respectively
(non-significant difference). The incidence varied according to the
geographical area. However, the incidence in nurses and health care
assistants was not different from the general population (7.5/100000).
CONCLUSIONS: In a low-incidence country, such as France, the implementation
of measures to prevent occupational TB among HCWs has been effective.
These preventive measures should be maintained but medical follow-up
could be revised.
BibTeX:
@article{Gehanno2016a,
  author = {Gehanno, J.-F. and Abiteboul, D. and Rollin, L.},
  title = {Incidence of tuberculosis among nurses and health care assistants in {France}.},
  month = {September},
  journal = {Occupational medicine (Oxford, England)},
  year = {2016},
  doi = {10.1093/occmed/kqw138}
}

Abstract: Despite international initiatives like Orphanet, it remains difficult
to find up-to-date information about rare diseases. The aim of this
study is to propose an exhaustive set of queries for PubMed based
on terminological knowledge and to evaluate it versus the queries
based on expertise provided by the most frequently used resource
in Europe: Orphanet.Four rare disease terminologies (MeSH, OMIM,
HPO and HRDO) were manually mapped to each other permitting the automatic
creation of expended terminological queries for rare diseases. For
30 rare diseases, 30 citations retrieved by Orphanet expert query
and/or query based on terminological knowledge were assessed for
relevance by two independent reviewers unaware of the query's origin.
An adjudication procedure was used to resolve any discrepancy. Precision,
relative recall and F-measure were all computed.For each Orphanet
rare disease (n = 8982), there was a corresponding terminological
query, in contrast with only 2284 queries provided by Orphanet. Only
553 citations were evaluated due to queries with 0 or only a few
hits. There were no significant differences between the Orpha query
and terminological query in terms of precision, respectively 0.61
vs 0.52 (p = 0.13). Nevertheless, terminological queries retrieved
more citations more often than Orpha queries (0.57 vs. 0.33; p = 0.01).
Interestingly, Orpha queries seemed to retrieve older citations than
terminological queries (p < 0.0001).The terminological queries proposed
in this study are now currently available for all rare diseases.
They may be a useful tool for both precision or recall oriented literature
search.
BibTeX:
@article{Griffon2016a,
  author = {Griffon, N. and Schuers, M. and Dhombres, F. and Merabti, T. and Kerdelhué, G. and Rollin, L. and Darmoni, S. J.},
  title = {Searching for rare diseases in PubMed: a blind comparison of Orphanet expert query and query based on terminological knowledge.},
  journal = {BMC Med Inform Decis Mak},
  school = {S, 75006, Paris, France; Univ Paris 13, Sorbonne Paris Cité, LIMICS (UMR_S 1142), 93430, Villetaneuse, France.},
  year = {2016},
  volume = {16},
  number = {1},
  pages = {101},
  url = {http://dx.doi.org/10.1186/s12911-016-0333-0},
  doi = {10.1186/s12911-016-0333-0}
}

Abstract: Background Physicians are increasingly encouraged to practice evidence-based
medicine (EBM), and their decisions require evidence based on valid
research. Existing literature shows a mismatch between general practitioners’
(GPs) information needs and evidence available online. The aim of
this study was to explore the attitudes and behavior of residents
in general medicine and GPs when seeking medical information online.
Methods Five focus groups (FGs) involving residents in general medicine
and GPs were conducted between October 2013 and January 2014. The
overall number of participants recruited was 35. The focus group
discussion guide focused on participants’ experiences in searching
for health information on the Internet, perceived barriers and possible
solutions for improving the quality of their own search processes.
Descriptive analysis was performed by three researchers. Results
Participants described a wide range of research topics, covering
all general medicine core competencies, and especially patient-oriented
topics. They used a limited list of websites. Participants were not
confident about their ability to assess the quality of the information
they found. Their assessment of data quality was based on intuition,
and they mainly sought concordance with their existing knowledge.
The way the data were exposed was considered very important. Participants
were looking for information that was directly linked to their clinical
practice. Information seeking processes varied among participants.
They felt they had not mastered query building for conducting searches,
and were aware of the impact this shortcoming had on the quality
of their search for information. Conclusions Residents in general
medicine and GPs understood the importance of EBM and the need for
objective and reliable information. The present study highlights
the difficulties in identifying this kind of information, and suggests
ideas for improvement. Available search tools should change in order
to fill the gap with real-world clinical practice, for example by
integrating a patient-centred approach.
BibTeX:
@article{Schuers2016,
  author = {Schuers, Matthieu and Griffon, Nicolas and Kerdelhue, Gaëtan and Foubert, Quentin and Mercier, Alain and Darmoni, Stéfan J.},
  title = {Behavior and attitudes of residents and general practitioners in searching for health information: {From} intention to practice},
  month = {May},
  journal = {International Journal of Medical Informatics},
  year = {2016},
  volume = {89},
  pages = {9--14},
  url = {http://www.sciencedirect.com/science/article/pii/S1386505616300235},
  doi = {10.1016/j.ijmedinf.2016.02.003}
}

Abstract: OBJECTIVES: To summarize excellent current research in the field of
Knowledge Representation and Management (KRM) within the health and
medical care domain. METHOD: We provide a synopsis of the 2016 IMIA
selected articles as well as a related synthetic overview of the
current and future field activities. A first step of the selection
was performed through MEDLINE querying with a list of MeSH descriptors
completed by a list of terms adapted to the KRM section. The second
step of the selection was completed by the two section editors who
separately evaluated the set of 1,432 articles. The third step of
the selection consisted of a collective work that merged the evaluation
results to retain 15 articles for peer-review. RESULTS: The selection
and evaluation process of this Yearbook's section on Knowledge Representation
and Management has yielded four excellent and interesting articles
regarding semantic interoperability for health care by gathering
heterogeneous sources (knowledge and data) and auditing ontologies.
In the first article, the authors present a solution based on standards
and Semantic Web technologies to access distributed and heterogeneous
datasets in the domain of breast cancer clinical trials. The second
article describes a knowledge-based recommendation system that relies
on ontologies and Semantic Web rules in the context of chronic diseases
dietary. The third article is related to concept-recognition and
text-mining to derive common human diseases model and a phenotypic
network of common diseases. In the fourth article, the authors highlight
the need for auditing the SNOMED CT. They propose to use a crowdbased
method for ontology engineering. CONCLUSIONS: The current research
activities further illustrate the continuous convergence of Knowledge
Representation and Medical Informatics, with a focus this year on
dedicated tools and methods to advance clinical care by proposing
solutions to cope with the problem of semantic interoperability.
Indeed, there is a need for powerful tools able to manage and interpret
complex, large-scale and distributed datasets and knowledge bases,
but also a need for user-friendly tools developed for the clinicians
in their daily practice.
BibTeX:
@article{Soualmia2016,
  author = {Soualmia, L. F. and Charlet, J.},
  title = {Efficient {Results} in {Semantic} {Interoperability} for {Health} {Care}. {Findings} from the {Section} on {Knowledge} {Representation} and {Management}},
  month = {November},
  journal = {Yearbook of Medical Informatics},
  year = {2016},
  number = {1},
  pages = {184--187},
  doi = {10.15265/IY-2016-051}
}

Abstract: OBJECTIVES: Summarize excellent current research published in 2015
in the field of Public Health and Epidemiology Informatics. METHODS:
The complete 2015 literature concerning public health and epidemiology
informatics has been searched in PubMed and Web of Science, and the
returned references were reviewed by the two section editors to select
14 candidate best papers. These papers were then peer-reviewed by
external reviewers to allow the editorial team an enlightened selection
of the best papers. RESULTS: Among the 1,272 references retrieved
from PubMed and Web of Science, three were finally selected as best
papers. The first one presents a language agnostic approach for epidemic
event detection in news articles. The second paper describes a system
using big health data gathered by a statewide system to forecast
emergency department visits. The last paper proposes a rather original
approach that uses machine learning to solve the old issue of outbreak
detection and prediction. CONCLUSIONS: The increasing availability
of data, now directly from health systems, will probably lead to
a boom in public health surveillance systems and in large-scale epidemiologic
studies.
BibTeX:
@article{Toubiana2016,
  author = {Toubiana, L. and Griffon, N.},
  title = {Some {Innovative} {Approaches} for {Public} {Health} and {Epidemiology} {Informatics}},
  month = {November},
  journal = {Yearbook of Medical Informatics},
  year = {2016},
  number = {1},
  pages = {247--250},
  doi = {10.15265/IY-2016-047}
}

Abstract: Introduction et objectifs Cancers Pro Doc et Cancers Pro Actu sont
deux outils documentaires sur la prévention des cancers professionnels,
mis en place en 2013 par l’Institut national du cancer (INCa) et
ses partenaires, et qui comptent, fin 2015, plus de 1200 abonnés.
Après ces trois ans d’existence, le comité éditorial a souhaité réaliser
une enquête auprès des abonnés pour évaluer la pertinence et l’utilisation
de ces deux outils et permettre d’identifier des pistes d’amélioration.
Ces deux outils ont pour objectif de faciliter la recherche documentaire
de l’ensemble des professionnels de la santé au travail et de contribuer
à une diffusion plus large des informations parues dans ce domaine.
Cancers Pro Actu, bulletin de veille trimestriel, présente une sélection
d’outils et de supports d’aide à la pratique récemment parus et accessibles
gratuitement sur Internet. Cancers Pro Doc est une base de ressources
documentaires qui répertorie les documents pérennes de Cancers Pro
Actu et dispose d’un moteur de recherche avancée. Méthode et résultats
attendus La communication présentera les premiers enseignements d’une
enquête de satisfaction qui sera réalisée durant le premier semestre 2016 auprès
des abonnés de Cancers Pro Actu et des utilisateurs de Cancers Pro
Doc. L’enquête s’appuiera sur un questionnaire en ligne, puis sur
des entretiens plus approfondis avec des professionnels volontaires.
Par ailleurs, les données de consultation du bulletin de veille et
du site internet seront analysées. Nous disposerons ainsi de données
concernant les habitudes de lecture des utilisateurs, leurs pratiques
en matière de recherches documentaires et leurs perceptions vis-à-vis
des outils mis à disposition. Conclusion L’ensemble des résultats
collectés permettra d’identifier les évolutions nécessaires pour
améliorer Cancers Pro Doc et Cancers Pro Actu et répondre au mieux
aux attentes des abonnés et des lecteurs potentiels. Cette démarche
s’intègre dans une réflexion initiée en 2010 par l’INCa et un ensemble
d’acteurs de la santé au travail sur la circulation de l’information
sur la prévention des cancers professionnels et les possibilités
de l’améliorer.
BibTeX:
@article{Chauvet2016,
  author = {Chauvet, Claire and Jordan, Philippe and Bijaoui, Annie and Delepine, Anne and Fontaine, Bernard and Gehanno, Jean-François and Haberer, Michel and Hasni-Pichard, Helene},
  title = {Cancers {Pro} {Doc} et cancers {Pro} {Actu}. {Premiers} enseignements d’une enquête de lectorat},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {502--502},
  doi = {10.1016/j.admp.2016.03.341}
}

Abstract: Contexte Les différents facteurs ayant un impact sur le retour au
travail des patients atteints d’hémopathies malignes sont peu documentés.
Objectif Décrire et analyser les modalités de reprise et les déterminants
de la réussite ou de l’échec du maintien à l’emploi ou d’une réinsertion
professionnelle des patients atteints d’une hémopathie maligne. Méthode
Étude pilote médico-sociale observationnelle, non randomisée. Inclusion
des sujets atteints d’une hémopathie maligne dans le département
du Calvados, dont le diagnostic a été effectué entre le 1 er janvier
et le 31 décembre 2010, âgés de 18 à 55 ans au moment du diagnostic,
grâce aux données du registre des hémopathies malignes de Basse-Normandie.
Un auto-questionnaire de recueil d’informations propre à l’étude
et des questionnaires validés d’anxiété-dépression, de qualité de
vie et de fatigue ont été adressés aux patients inclus. Principaux
résultats Sur les 144 questionnaires envoyés, 72 questionnaires ont
été recueillis et 20 refus ont été signifiés. La population de l’étude
était constituée de 54 % d’hommes et de 46 % de femmes, avec une
moyenne d’âge de 49,8 ans. Seuls 60 % des sujets déclaraient avoir
bénéficié d’un arrêt de travail suite à la découverte de leur maladie
et la durée moyenne de celui-ci était de 21 mois. À la date de réception
des questionnaires, la majorité des sujets (85  n’était plus en
arrêt de travail. Parmi les sujets ayant bénéficié d’un arrêt de
travail, 47 % des sujets déclaraient avoir rencontré leur médecin
du travail en visite de pré-reprise. La majorité des sujets avait
repris une activité professionnelle dans la même entreprise qu’avant
le diagnostic (77 , avec le même type de contrat de travail (95 ,
et au même poste de travail (77 . La majorité des sujets de l’étude
(79  déclarait n’avoir bénéficié d’aucun aménagement de ses conditions
de travail et 31 % des sujets déclaraient avoir constaté un impact
négatif de leur maladie sur les conditions de reprise de leur activité
professionnelle. Les conditions de reprise du travail étaient considérées
comme suffisamment anticipées pour 56 % seulement des sujets, « pas
du tout » pour 13 % des sujets. Une minorité de sujets (29,5 
déclarait avoir l’impression de travailler « moins bien qu’avant »
la découverte de leur maladie, et 23 % déclaraient s’être sentis
pénalisés dans leur travail à cause de leur maladie. Conclusion Les
données riches recueillies dans le cadre de cette étude pilote et
le taux de réponse satisfaisant permettent d’envisager la réalisation
d’une étude multicentrique, incluant des sujets atteints d’une hémopathie
maligne en Basse-Normandie, Haute-Normandie, dans la zone de proximité
de Lille et dans la Somme.
BibTeX:
@article{Clin2016,
  author = {Clin, Bénédicte and Heutte, Natacha and Troussard, Xavier and Boulanger, Mathilde and Damaj, Ganghi-Laurent and Cornet, Edouard and Bouvier, Véronique and Guizard, Anne-Valérie and Fantoni-Quinton, Sophie and Leroyer, Ariane and Rollin, Laetitia and Doutrellot, Catherine and Launoy, Guy},
  title = {Analyse des déterminants médico-sociaux du maintien en emploi des patients atteints d’une hémopathie maligne (protocole {ADAMENTINE}). {Résultats} de l’étude pilote},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {383--383},
  doi = {10.1016/j.admp.2016.03.054}
}

Abstract: Introduction et méthode Cette étude a pour objectif de repérer les
facteurs de vulnérabilité face à la reprise du travail après un cancer.
Elle porte sur 77 sujets répartis en deux groupes (33 sujets qui
reprennent le travail sans accompagnement et 44 sujets qui s’adressent
à la consultation pluridisciplinaire d’aide à la reprise du travail
après un cancer du CHU de Rouen). Les caractéristiques psychologiques,
médicales, sociales et professionnelles des sujets non consultants
et des sujets consultants sont comparées. Résultats Des facteurs
de vulnérabilité étaient significativement plus souvent présents
chez les sujets consultants : – plus faible sentiment de contrôle
face aux événements traumatisants vécus (questionnaire EVE, Ferreri
et Vacher) ; – plus faible score moyen d’esprit combatif (Mac 44,
Cayrou et Dickès) ; – valeurs liées à la vie professionnelle plus
affectées par la maladie (échelle de valeurs, Fischer) ; – anticipation
d’une moindre compréhension de la part de l’entourage familial face
à la reprise du travail (questionnaire créé pour les besoins de l’étude) ;
– âge inférieur au moment du diagnostic de cancer ; – perte d’emploi
plus fréquente suite au diagnostic. Les taux de reprise du travail
sont de 73 % pour les non consultants et de 66 % pour les consultants.
Le test de Chi 2 ( χ 2 = 0,4086) n’indique pas de différence significative
( p = 0,52) entre les deux groupes. Chez les sujets ayant repris
une activité professionnelle, les délais moyens entre le diagnostic
et la reprise (en mois) sont de 17,54 ± 13,35 pour les sujets consultants
et de 16,78 ± 10,33 pour les non consultants. Le test- t ne montre
pas de différence significative ( p = 0,41) concernant le délai écoulé
entre le diagnostic de cancer et la reprise du travail entre les
sujets des deux groupes. Conclusion Les facteurs de vulnérabilité,
plus souvent présents dans le groupe des sujets ayant consulté, n’ont
pas eu d’incidence sur le taux de reprise du travail et le délai
moyen entre le diagnostic de cancer et la reprise. L’accompagnement
de la consultation d’aide à la reprise du travail a probablement
favorisé une forme de résilience et l’autonomie psychique chez ces
sujets face au retour à l’emploi. Cet accompagnement pourrait faire
émerger des ressources pour faire face à une vulnérabilité durable
dans la vie professionnelle. Les sujets non consultants présentent
des caractéristiques plutôt favorables à la reprise du travail, mais
des difficultés pèsent sur la vie professionnelle après le diagnostic
de cancer. Nous pouvons nous interroger sur le devenir et le vécu
de la reprise du travail, à moyen ou long terme, et sur la valeur
de ces ressources qui pourraient être moins opérantes dans une temporalité
et un contexte différents.
BibTeX:
@article{DeBlasi2016,
  author = {De Blasi, Géraldine and Bouteyre, Evelyne and Gehanno, Jean-François and Rollin, Laetitia},
  title = {Facteurs de vulnérabilité et résilience face à la reprise du travail après un cancer},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {386--387},
  doi = {10.1016/j.admp.2016.03.064}
}

Abstract: La prévention de l’acquisition d’une infection par un soignant constitue
le cœur de métier des professionnels de la lutte contre les infections
associées aux soins et des professionnels de la santé au travail
car : – une infection acquise par un soignant au cours de son activité
dans un établissement de santé (ES) est une infection nosocomiale ;
– un soignant atteint d’une maladie contagieuse peut participer à
la diffusion épidémique de celle-ci dans l’ES ; – une infection chez
un soignant peut conduire, lorsqu’elle est grave et/ou contagieuse
à un arrêt de travail de ce soignant, arrêt de nature à déstabiliser
le fonctionnement du service. La vaccination du personnel de santé
(PS) est une des missions importantes des services de santé au travail.
La vaccination est un moyen de prévention primaire efficace ayant
permis de diminuer, de contrôler, voire d’éradiquer de nombreuses
maladies infectieuses à prévention vaccinale assurant la protection
des populations. Ainsi, la promotion de la vaccination par une politique
vaccinale volontariste représente un enjeu majeur de santé publique.
Pour guider les pratiques, des recommandations vaccinales existent
dont certaines concernent spécifiquement les PS et autres personnels
en contact avec des sujets à risque dans les domaines de la santé
et du médico-social. Malgré ces recommandations, hormis quelques
travaux ayant montré que si les PS étaient globalement bien couverts
par les vaccinations obligatoires, ils étaient en revanche très insuffisamment
couverts par les vaccinations recommandées, les données de couverture
vaccinale (CV) chez le PS ne sont pas nombreuses en France. En 2013,
une action nationale prioritaire d’évaluation et de suivi de la CV
dans les ES a été suggérée, proposition reprise dans les orientations
du Propias 2015. Pour cette raison, le choix a été fait de déployer
le carnet de vaccination électronique (CVE) de MesVaccins.net (association
loi 1901 à but non lucratif). Celui-ci est doté d’un système expert
qui : – assure un diagnostic personnalisé, précis et immédiat de
l’état vaccinal de chaque personnel, et fournit une aide à la décision ;
– permet d’être alerté des vaccinations à programmer, avec intégration
en temps réel de l’évolution des recommandations vaccinales ; – informe
des éventuelles données de pharmacovigilance à prendre en compte.
Le réseau national coordonné par le Raisin se donne pour objectif
de déployer cette méthode standardisée de recueil et de suivi des
vaccinations et des conditions d’immunisation du personnel des ES
à partir du CVE de MesVaccins.net. La phase pilote débute en 2016.
Dans un deuxième temps, le dispositif explorera la capacité de générer
chez les soignants des données de CV à différents échelons géographiques.
BibTeX:
@article{Floret2016,
  author = {Floret, Nathalie and Abiteboul, Dominique and Bouvet, Elisabeth and Gehanno, Jean-François and Guthmann, Jean-Paul and Koeck, Jean-Louis and Launay, Odile and Lecieux, Fabienne and L’heriteau, François and Rabaud, Christian and Rolland, Patrick and Touche, Sylvie and Verdun-Esquer, Catherine},
  title = {Réseau de surveillance de la couverture vaccinale et des conditions d’immunisation du personnel des établissements de santé : pourquoi, comment},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {428--429},
  doi = {10.1016/j.admp.2016.03.175}
}

Abstract: Les soignants sont un groupe professionnel à risque d’exposition au
virus grippal, mais ils sont également régulièrement impliqués dans
des cas ou des épidémies de grippe nosocomiale. Tous les soignants,
et pas uniquement ceux en contact avec des patients à risque, devraient
donc bénéficier de la vaccination contre la grippe. Bien que les
vaccins actuellement disponibles aient une efficacité limitée, tant
pour la prévention de la grippe chez les soignants que pour la réduction
de la morbidité ou de la mortalité des patients à risques, leur rapport
bénéfice–risque reste favorable. Toutefois, les réticences sont fortes
et les taux de vaccination des personnels de soins restent faibles,
notamment en France. Il existe une abondante littérature sur les
actions à mettre en œuvre pour améliorer la couverture vaccinale.
Le fait de rendre la vaccination antigrippale obligatoire pour les
soignants est de nature à atteindre cet objectif, mais avec des inconvénients
qui doivent être pris en considération. Enfin, la politique de prévention
ne peut reposer sur la seule vaccination ; il ne faut pas méconnaître
l’importance du respect des précautions standards dans la prévention
des grippes nosocomiales.
BibTeX:
@article{Gehanno2016,
  author = {Gehanno, J.-F. and Rollin, L.},
  title = {Vaccination antigrippale du personnel soignant},
  journal = {Journal des Anti-infectieux},
  year = {2016},
  volume = {18},
  number = {2},
  pages = {79--84},
  doi = {10.1016/j.antinf.2016.02.001}
}

BibTeX:
@article{Griffon2016b,
  author = {Griffon, Nicolas and Schuers, Matthieu and Darmoni, Stefan J.},
  title = {Littérature {Scientifique} en {Santé} ({LiSSa}) : une alternative à l’anglais ?},
  month = {November},
  journal = {La Presse Médicale},
  year = {2016},
  volume = {45},
  number = {11},
  pages = {955--956},
  url = {http://www.sciencedirect.com/science/article/pii/S0755498216303505},
  doi = {10.1016/j.lpm.2016.11.001}
}

Abstract: Les langages iconiques permettent de représenter des concepts par
la combinaison de primitives graphiques (couleurs, pictogrammes...).
Les exemples sont nombreux, des pan- neaux routiers aux icônes des
interfaces utilisateur. Cependant, ces langages n’associent pas de
sémantique logique à leurs icônes, ce qui peut poser divers problèmes
: des combinaisons inconsistantes de primitives graphiques, des interprétations
différentes d’une même icône par deux personnes, des difficultés
à mettre en correspondance les icônes avec des concepts de ressources
termino-ontologiques existantes... Dans cet article, nous proposons
une méthode de formalisation de la sémantique d’un lan- gage iconique
à l’aide d’une ontologie. Cette méthode a initialement été développée
pour le langage iconique VCM (Visualisation des Concepts en Médecine),
qui permet de représenter par des icônes les principaux concepts
médicaux (antécédents, maladies, traitements...). Nous montrons que
cette méthode est généralisable à d’autres langages iconiques en
l’appliquant à la signalisation routière. Nous décrivons quatre applications
de la formalisation du langage : la vérification de la consistance
des icônes constituées, l’alignement semi-automatique des icônes
avec une terminologie médicale, la génération d’un lexique des pictogrammes
et la génération de libellés pour les icônes.
BibTeX:
@article{Lamy2016,
  author = {Lamy, JB and Soualmia, LF and Duclos, C and Venot, A},
  title = {Formalisation de la Sémantique des Langages Iconiques : Méthode à base d’Ontologie et Applications},
  journal = {Revue d’Intelligence Artificielle},
  year = {2016},
  volume = {30},
  number = {5},
  pages = {579-606},
  url = {http://ria.revuesonline.com/article.jsp?articleId=36942},
  doi = {10.3166/RIA.30.579-606}
}

Abstract: Objectif Décrire les risques psycho-sociaux (RPS) et la santé psychique
des différentes catégories du personnel hospitalier, puis étudier
les liens entre les troubles neuropsychiques et ces RPS. Méthode
et matériels La démarche EVREST a été appliquée en 2014, un entretien
médico-professionnel, avec passation du questionnaire EVREST par
une infirmière ou un médecin du travail, a été proposé aux salariés
nés en octobre d’une année paire du centre hospitalier universitaire
de Rouen ( n = 322). Les résultats quantitatifs et qualitatifs des
entretiens ont été analysés selon le groupe professionnel (médical,
soignant ou non médical-non soignant). Une comparaison avec les résultats
nationaux EVREST 2013–2014 des travailleurs français a été effectuée.
Enfin les facteurs associés aux troubles neuropsychiques ont été
étudiés à l’aide d’une régression logistique. Résultats Deux cent
soixante salariés (taux de participation = 81  ont participé.
Les personnels hospitaliers déclaraient des contraintes psychosociales
plus importantes que les autres travailleurs français, en particulier
le personnel médical et le personnel soignant. La proportion de troubles
neuropsychiques définis par l’association « fatigue et anxiété/nervosité
et troubles du sommeil » était plus importante chez le personnel
hospitalier de façon générale par comparaison aux résultats nationaux
(22 % versus 7 , sans différence significative selon le groupe
professionnel. Les facteurs associés significativement à la présence
de troubles neuropsychiques étaient la pression temporelle (OR =
3,5, IC95 1,7–7,6]), l’absence de possibilité d’entraide (OR =
2,3, IC95 1,0–5,3]) et la peur de perdre son emploi (OR = 5,6 IC95 
[1,7–19,2]). Conclusion Les personnels hospitaliers sont exposés
à des risques psycho-sociaux et déclarent des troubles neuropsychiques
dans des proportions élevées par rapport aux autres travailleurs
français. Des liens significatifs entre troubles neuro-psychiques
et certains RPS ont été mis en évidence. Ces éléments et, en particulier
les éléments qualitatifs entendus lors des entretiens, servent de
base pour le développement d’un plan concret de prévention des RPS
au sein de ce CHU.
BibTeX:
@article{Lesueur2016,
  author = {Lesueur, Nicoleta and Leroyer, Ariane and Gehanno, Jean-François and Caillard, Jean-François and Rollin, Laetitia},
  title = {Évaluation du retentissement des risques psychosociaux sur l’état de santé du personnel hospitalier : étude comparative à l’aide de la démarche {EVREST} dans un centre hospitalier universitaire},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {411--411},
  doi = {10.1016/j.admp.2016.03.125}
}

Abstract: Objectifs Décrire l’impact sur l’état de santé physique et psychique
des différents risques psychosociaux (RPS) auxquels sont exposés
les aides à domicile et les techniciennes d’intervention socio-familiale
(TISF), ainsi que proposer des pistes de prévention des RPS pour
les salariés du secteur de service à la personne. Matériel et méthodes
Étude prospective, monocentrique, descriptive, à l’aide du questionnaire
EVREST (Évolutions et relations en santé au travail) proposé en visite
périodique avec le médecin du travail ou lors d’entretien infirmier,
réalisée sur la période du 1 er octobre 2013 au 30 janvier 2015 pour
les aides à domicile et des TISF travaillant dans le cadre d’une
association d’aide à la personne, en Rouen et agglomération. Résultats
Un total de 246 salariés ont été inclus, principalement des femmes
(99 , avec un âge moyen de 44 ans. Plus de la moitié des salariés
travaillaient à temps partiel et un tiers des salariés travaillait
avec une pression temporelle forte. Ce métier était apprécié sur
certains aspects : près de 8 salariés sur 10 déclaraient faire un
travail varié en pleine autonomie, par contre un tiers de la population
ne disposait pas de possibilités d’entraide. La majorité des salariés
rapportaient des contraintes physiques au poste, pénibles pour la
moitié d’entre eux. Malgré une moyenne d’âge assez jeune, la santé
des salariés était plutôt altérée : atteintes du rachis dorsolombaire
(1/3 des salariés), atteints du membre supérieur (20 , troubles
neuropsychiques (9 . Quarante-sept pour cent des salariés déclaraient
avoir été victimes d’incivilités ou d’agressions physiques répétées
au cours de leur carrière. La pression psychologique était significativement
associée à la présence de troubles neuropsychiques. Conclusion Notre
étude met en évidence des contraintes organisationnelles, physiques
et psychosociales chez les travailleurs à domicile. Les troubles
musculo-squelettiques et neuropsychiques sont associés significativement
à la présence de ces contraintes. Un plan de prévention a pu être
proposé à partir de ces constats.
BibTeX:
@article{Lupse2016,
  author = {Lupse, Mihaela and Gehanno, Jean-François and Meyer, Michèle and Rollin, Laetitia},
  title = {Évaluation du retentissement des risques psychosociaux sur l’état de santé des travailleurs à domicile},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {409--410},
  doi = {10.1016/j.admp.2016.03.121}
}

Abstract: Objectifs Étudier le profil de la situation professionnelle des patients
douloureux chroniques ; – évaluer l’impact de la mise en place d’une
consultation spécialisée « Douleur et Travail » sur le maintien dans
l’emploi des patients douloureux chroniques ; – accompagner les patients
douloureux chroniques pour le maintien dans l’emploi et/ou la reprise
d’une activité professionnelle. Le principe de cette consultation
est la non-substitution au médecin du travail du salarié, le but
étant plutôt l’orientation et la reprise de contact avec celui-ci,
en temps utile, avant la reprise du travail. Méthodologie Les sujets
ayant consulté le Centre d’étude et traitement de la douleur de CHU
de Rouen ou la Structure douleur de l’hôpital d’Évreux et répondant
aux critères d’inclusion suivants sont adressés à la consultation :
– patients non salariés ou n’ayant pas une activité professionnelle,
âgés d’au moins 18 ans, atteints d’une pathologie douloureuse chronique
souhaitant le maintien dans l’emploi ou intégrer le monde du travail ;
– patients salariés atteints d’une pathologie douloureuse chronique,
n’ayant pas eu une visite avec leur médecin du travail dans les six
derniers mois. Critères d’exclusion : – visite avec le médecin du
travail dans les 6 derniers mois ou prévue dans le mois qui suit ;
– démarches de reclassement professionnel déjà en cours ; Trois temps
sont prévus : – une consultation avec pour objectif d’évaluer : – le
statut professionnel, – l’incapacité dans la vie (questionnaire SF-12)
et au travail, – la prise de contact ou non avec le médecin du travail
et les démarches effectuées. Un bilan des aptitudes médicales récentes
est réalisé puis orientation vers les acteurs du maintien dans l’emploi :
– entretien téléphonique au bout de 6 semaines pour évaluation de
l’avancement des démarches entreprises ; – une consultation de suivi
à trois mois pour faire le bilan sur l’avancement des démarches et
conseil. Résultats Les résultats présentés lors du congrès concerneront
les patients ayant bénéficié d’une première consultation entre le
01/11/2015 et le 01/03/2016. À la date du 06/01/2016, 21 patients
sont inclus, notre objectif est d’étudier au moins 30 patients sur
la période totale. L’analyse des résultats concernera le profil des
patients inclus ainsi que le nombre des objectifs accomplis après
la première consultation à trois mois.
BibTeX:
@article{Lupse2016a,
  author = {Lupse, Mihaela and Rollin, Laetitia and Gehanno, Jean François and Gislard, Antoine and Pouplin, Sophie},
  title = {Mise en place d’une consultation spécialisée « {Douleur} et {Travail} » au {CHU} de {Rouen}},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {382--382},
  doi = {10.1016/j.admp.2016.03.052}
}

BibTeX:
@article{Melissa2016,
  author = {Mélissa, Mary and Lina, Soualmia and Xavier, Gansel},
  title = {Interopérabilité sémantique entre vocabulaires contrôlés. évaluation de la qualité des alignements sur des données de standards du diagnostic in vitro},
  month = {December},
  journal = {Ingénierie des systèmes d'information},
  year = {2016},
  volume = {21},
  number = {5-6},
  pages = {55--81},
  url = {http://isi.revuesonline.com/article.jsp?articleId=37160},
  doi = {10.3166/isi.21.5-6.55-83}
}

Abstract: Introduction Les allergies professionnelles sont en très forte augmentation
en France. L’asthme professionnel peut être provoqué par divers allergènes,
selon les corps de métiers. Nous allons présenter un cas d’asthme
professionnel à la tulipe, diagnostiqué en consultation pluridisciplinaire
de médecine du travail et allergologie. Méthodes Une femme de 51
ans, fleuriste, était atteinte de toux, dyspnée et rhino-conjonctivite
lors de l’effeuillage de tulipes, mais ne présentait ni altération
de l’état général ni fièvre. Des tests de provocation bronchique
à la tulipe ont été réalisés en milieu hospitalier. Des prick + prick-tests
à la tulipe étaient réalisés avec le pistil, la feuille, l’étamine,
la tige, la sève de la fleur. Ils ont également été réalisés chez
deux témoins sains. Résultats Le test de provocation bronchique à
la métacholine ainsi que celui à l’effeuillage de tulipes étaient
positifs. L’asthme à la tulipe était donc confirmé. Les prick-tests
à la tulipe n’étaient positifs que chez la patiente, confirmant le
mécanisme allergique IgE médié. Cliniquement, l’éviction de la tulipe
par le changement de poste de travail a permis l’amendement complet
de la symptomatologie. Discussion L’asthme professionnel à la tulipe
est peu connu. Seuls quatre autres cas similaires ont été précédemment
décrits dans la littérature. La tulipe est plus connue en dermato
allergologie car son allergène majeur, la tulipaline A, est responsable
d’allergies de contact fréquentes, croisées avec d’autres fleurs.
Conclusion Nous rapportons un cas exceptionnel d’asthme professionnel
à la tulipe chez une fleuriste. Son diagnostic de certitude nécessite
une méthodologie rigoureuse et chronophage, facilitée par le cadre
d’une consultation pluridisciplinaire de médecine du travail et d’allergologie.
BibTeX:
@article{Merault2016,
  author = {Merault, C. and Tetart, F. and Kuntz, A. and Gehanno, J.F. and Joly, P. and Gislard, A.},
  title = {Asthme professionnel allergique aux liliacées : à propos d’un cas},
  journal = {Revue Francaise d'Allergologie},
  year = {2016},
  volume = {56},
  number = {3},
  pages = {298--298},
  doi = {10.1016/j.reval.2016.02.110}
}

Abstract: La reprise du travail est une étape primordiale pour les patients
atteints d’un cancer mais celle-ci peut s’avérer difficile et nécessiter
un accompagnement adapté. Le Centre de consultations de pathologie
professionnelle CHU de Rouen a créé, en 2006, une consultation pluridisciplinaire
d’aide au retour au travail après un cancer. Les objectifs de cette
étude descriptive étaient de présenter cette consultation, de connaître
le ressenti des patients vis-à-vis d’un tel dispositif et d’identifier
des facteurs prédictifs de retour au travail. Nous avons réalisé
l’analyse descriptive des patients vus entre 2006 et 2011, à partir
des dossiers médicaux, puis nous leur avons envoyé un questionnaire
détaillé sur les conditions de reprise du travail, sur la réalisation
des conseils prodigués lors de la consultation et sur l’intérêt de
cette consultation. Cent vingt et un patients ont été inclus, 22 hommes
(18  et 99 femmes (82 . Les localisations cancéreuses les plus
fréquentes étaient le sein et les hémopathies malignes, respectivement
65 % (79/121) et 12 % (14/121). Quatre-vingt-six patients (71 
étaient en rémission. Cent quatre patients (86  étaient salariés
lors du diagnostic dont 84 (69  en CDI. Les démarches médico-sociales
proposées ont eu un taux de réalisation allant de 28 à 72 % selon
les mesures. Soixante-six pour cent ([IC 95 % = 57–75]) des patients
ont repris, tous délais confondus. Vingt-cinq pour cent, soit 20 des
80 patients ayant repris, expriment des difficultés avec leur employeur
et 18 % (14/80) expriment des difficultés avec les collègues. L’analyse
multivariée a retrouvé trois facteurs associés significativement
à la reprise du travail : avoir un contrat à durée indéterminée lors
du diagnostic de cancer OR = 4,7 IC 95 1,4–16,0], cancer non évolutif
OR = 5 IC 95 1,25–25] et avoir bénéficié d’un accompagnement par
le psychologue de la consultation OR = 2,7 IC 95 1,0–6,9]. Les
différents constats de cette étude ont permis d’établir des pistes
d’amélioration pour cette consultation.
BibTeX:
@article{Rollin2016a,
  author = {Rollin, Laetitia and Boucher, Line and de Blasi, Géraldine and Bouteyre, Evelyne and Gislard, Antoine and Gehanno, Jean-François},
  title = {Évaluation d’une consultation pluridisciplinaire d’aide au retour au travail après cancer},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {395--396},
  doi = {10.1016/j.admp.2016.03.086}
}

Abstract: En France, parmi les 350 000 personnes touchées par le cancer chaque
année, environ 100 000 d’entre elles sont en situation d’emploi et
travaillent au moment du diagnostic. La réinsertion professionnelle
après un cancer est un facteur de qualité de vie des patients, mais
également un enjeu de santé publique. Il s’agit d’une priorité soulignée
dans les plans cancers qui se succèdent depuis 2003. L’objectif de
cette communication est de décrire l’état des connaissances actuelles
concernant le maintien dans l’emploi des patients après cancer. La
métaanalyse deffectuée par Menhert en 2011 a retrouvé un taux de
reprise du travail après cancer de 63,5 % avec des extrêmes allant
de 24 à 94 % selon les études. Cette grande hétérogénéité est expliquée
par des facteurs liés à la pathologie (localisation, stades, traitement),
mais également par d’autres facteurs comme le sens du travail, les
conditions de travail, les cadres légaux et les politiques sociales
variables selon les pays. Il est donc intéressant, dans la réflexion
pour l’accompagnement des patients, d’examiner les études françaises.
L’étude de la DREES, menée en France en 2006, a montré que 67 %
des patients actifs lors du diagnostic avaient repris une activité
professionnelle à 2 ans. Ces données ont permis de mettre en évidence
une différence de vitesse dans le processus de retour à l’emploi
selon le genre, les hommes reprenant plus rapidement dans les 6 mois
qui suivent le diagnostic et les femmes reprenant graduellement dans
les 18 mois. L’étude Vican2 a confirmé que les patients atteints
de cancer étaient plus sujets à la perte d’emploi que la population
générale. Elle a également mis en évidence de fortes inégalités dans
la reprise du travail, les personnes les plus vulnérables vis-à-vis
de la perte d’emploi étant celles appartenant aux catégories socio-professionnelles
dites d’exécution, les plus jeunes et les plus âgées, les personnes
mariées, avec un niveau d’étude inférieur au baccalauréat, avec des
contrats précaires, et celles travaillant dans les petites et moyennes
entreprises. Des interventions visant à améliorer les retours à l’emploi
après cancer ont été mises en place dans de nombreux pays. La métaanalyse
de De Boer et al. a montré que seules les interventions pluridisciplinaires
apportent des résultats probants quant au retour à l’emploi. En revanche,
elles ne sont pas plus efficaces que les « soins ordinaires » sur
la qualité de vie des participants. Les études visant à préciser
le contenu le plus approprié de ces interventions pluridisciplinaires
sont à poursuivre.
BibTeX:
@article{Rollin2016,
  author = {Rollin, Laetitia and De Blasi, Geraldine and Gehanno, Jean-François},
  title = {Cancer et trajectoires professionnelles},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {495--495},
  doi = {10.1016/j.admp.2016.03.323}
}

Abstract: Few data from primary care settings are available about asthma prevalence. The aim of this study was to evaluate the prevalence of asthma consultations in general practice, and to describe their characteristics. This was a multicenter, cross-sectional national study, conducted in general practice. Investigators were 54 interns from 27 medical schools. Between December 2011 and April 2012, they collected and entered variables specific to each consultation over a period of 20 days from a structured electronic health record using the International classification of primary care (ICPC-2) together with data about their trainer(s). Data were recorded for 20,613 consultations with 45,582 consultation outcomes described. Asthma represented 348 (1.69%) of consultations. The presence of an asthma code was associated with fewer reasons for the consultation, but with more processes of care. Forty-two percent of other consultation results associated with asthma in the same consultation concerned chronic diseases. Our findings suggest that asthma remains underdiagnosed in general practice in France. In order to address this problem, the development of validated diagnostic tools that can be used in general practice settings, and a better access to spirometry, may be directions to explore in future research.
BibTeX:
@article{Schuers2016d,
  author = {Schuers, M and Chopinaud, P-A and Guihard, H and Mercier, A},
  title = {Prévalence des consultations pour asthme en médecine générale},
  month = {November},
  journal = {Revue des maladies respiratoires},
  year = {2016},
  volume = {33},
  pages = {781--788},
  doi = {10.1016/j.rmr.2016.01.005}
}

Abstract: Introduction. En France, à la fin des années 1990, 97 % des infections
respiratoires basses (IRB) prises en charge en soins primaires étaient
traitées par antibiotiques. Il n’existe pas de données récentes décrivant
cette situation avec précision. Objectif. L’objectif de cette étude
était de décrire la prescription d’antibiotiques dans les infections
respiratoires basses en France. Méthode. Une étude observationnelle
auprès de médecins généralistes a été réalisée. Les participants
ont été sélectionnés au sein d’un groupe de 200 médecins exerçant
dans deux régions du nord de la France. Tous les médecins ont été
contactés par mail, et ont complété un questionnaire prospectif sur
tous les patients présentant une bronchite aiguë ou une exacerbation
de BPCO.Résultats. Trente-six médecins généralistes ont recruté 193
patients. Cent patients ont reçu un traitement antibiotique (52 .
Des antibiotiques ont été prescrits chez 46 % des patients présentant
une bronchite aiguë et chez 89 % des patients présentant une exacerbation
de BPCO. Le genre féminin des patients (OR : 2,49 ; IC95 : 1,47-4,24),
la durée de la toux (OR : 5,70 ; IC95 : 1,70-19,23), une température
supérieure à 38,5°C (OR : 30,39 ; IC95 : 3,99-231,60) et le diagnostic
d’exacerbation de BPCO (OR : 8,69 ; IC95 : 1,72-43,86) étaient associés
à une proportion plus élevée de prescription d’antibiotiques, toutes
classes confondues. Conclusion. Ces résultats montrent une diminution
significative de la prescription d’antibiotiques dans les IRB, mais
des efforts restent nécessaires pour améliorer la prise en charge
de ces patients.
BibTeX:
@article{Schuers2016b,
  author = {Schuers, M. and Rossignol, L and Laouénan, C and Le Bel, J and Pasque, A and Guihard, H and Aubert, JP and Aubin Auger, I.},
  title = {Prise en charge des infections respiratoires basses en soins primaires en {France} : une étude transversale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2016},
  number = {127},
  pages = {196--203}
}

Abstract: Position du problème Une expérimentation a été lancée en 2013 pour
évaluer l’impact de la consultation du dossier pharmaceutique dans
les services d’urgences, de gériatrie et d’anesthésie-réanimation
de 55 établissements hospitaliers. L’objectif de cette étude était
d’évaluer l’intérêt et l’utilisabilité du dossier pharmaceutique
auprès des médecins et pharmaciens utilisateurs. Méthodes Un auto-questionnaire
électronique a été envoyé à tous les pharmaciens, anesthésistes-réanimateurs,
gériatres et urgentistes des 55 établissements expérimentateurs du
dossier pharmaceutique. Ce questionnaire évaluait l’utilisabilité
du dossier pharmaceutique via la traduction française de l’échelle
d’utilisabilité des systèmes, ainsi que l’usage du dossier pharmaceutique,
son intérêt et ses limites perçues dans la pratique clinique et la
satisfaction générale vis-à-vis de l’outil. Les questionnaires ont
été collectés de novembre 2014 à janvier 2015. Résultats Quatre-vingt-seize
questionnaires ont été recueillis. Ils concernaient 47 centres hospitaliers,
soit 86 % des 55 établissements expérimentateurs du dossier pharmaceutique.
Le recoupement des réponses a permis d’identifier 36 établissements
au sein desquels le dossier pharmaceutique était actif. Soixante-treize
questionnaires remplis par des praticiens ayant pu expérimenter le
dossier pharmaceutique ont pu être exploités. Parmi les répondants,
on comptait 57 % de pharmaciens (n = 42) et 43 % de médecins (n
= 31), dont 13 gériatres, 11 urgentistes et 7 anesthésistes-réanimateurs.
Le score moyen d’utilisabilité du dossier pharmaceutique était de
62,5 sur 100. Il ne variait ni selon la profession du répondant,
ni selon son ancienneté d’exercice. Il était positivement corrélé
à la fréquence d’utilisation. Plus de la moitié des répondants déclaraient
utiliser rarement, ou jamais, le dossier pharmaceutique. La durée
de la période d’accès aux données du dossier était considérée comme
insuffisante. L’absence de mention des posologies des médicaments
délivrés, le faible nombre de patients disposant de leur carte d’assurance
maladie et le faible nombre de patients ayant un dossier pharmaceutique
ouvert constituaient les principaux obstacles à une plus grande utilisation
du dossier pharmaceutique. Conclusion Deux ans après le début de
l’expérimentation visant à élargir l’accès au dossier pharmaceutique
à des professionnels médicaux, les premiers éléments d’évaluation
sont encourageants. Il reste nécessaire d’évaluer les conséquences
de l’accès au dossier pharmaceutique pour les médecins.
BibTeX:
@article{Schuers2016a,
  author = {Schuers, M. and Timsit, M. and Gillibert, A. and Fred, A. and Griffon, N. and Bénichou, J. and Darmoni, S.J. and Staccini, P.},
  title = {Intérêt et utilisabilité du dossier pharmaceutique en pratique médicale. {Enquête} auprès de médecins et pharmaciens hospitaliers (étude {MATRIX})},
  month = {September},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2016},
  volume = {64},
  number = {4},
  pages = {229--236},
  url = {http://linkinghub.elsevier.com/retrieve/pii/S0398762016302905},
  doi = {10.1016/j.respe.2016.05.001}
}

BibTeX:
@article{Cabot2016,
  author = {Cabot, Chloé and Lelong, Romain and Grosjean, Julien and Soualmia, Lina F. and Darmoni, Stéfan J.},
  title = {Retrieving Clinical and Omic Data from Electronic Health Records.},
  journal = {Stud Health Technol Inform},
  school = {TIBS, LITIS EA 4108, Rouen, France.},
  year = {2016},
  volume = {221},
  pages = {115},
  url = {https://www.researchgate.net/profile/Lina_Soualmia/publication/280066101_Integrating_and_Retrieving_Clinical_and_Omic_Data_in_Electronic_Health_Records/links/55a7a47408aeceb8cad65695.pdf},
  doi = {10.3233/978-1-61499-633-0-115}
}

BibTeX:
@inproceedings{Cabot2016a,
  author = {Cabot, C and Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {SIBM at CLEF eHealth Evaluation Lab 2016: Extracting Concepts in French Medical Texts with ECMT and CIMIND},
  booktitle = {2016 Conference and Labs of the Evaluation Forum, CLEF},
  year = {2016},
  pages = {47-60},
  url = {http://ceur-ws.org/Vol-1609/16090047.pdf}
}

BibTeX:
@inproceedings{Gomez-Sanchez2016,
  author = {Gómez-Sánchez, AF and González-Cantalejo, M and Kerdelhué, G and Iriarte, P and Isabel-Gómez, R},
  title = {Evaluating the information retrieval quality and methodological accuracy of Systematic Reviews and Meta-analysis on congenital malformations (2004-2014)},
  booktitle = {EAHIL},
  year = {2016}
}

BibTeX:
@inproceedings{Lelong2016,
  author = {Lelong, R and Cabot, C and Soualmia, LF and Darmoni, SJ},
  title = {Semantic Search Engine to Query into Electronic Health Records with a Multiple-Layer Query Language},
  booktitle = {MEDIR workshop},
  year = {2016},
  url = {http://medir2016.imag.fr/data/MEDIR_2016_paper_8.pdf}
}

BibTeX:
@inproceedings{Cabot2016b,
  author = {Cabot, Chlo{\'e} and Soualmia, Lina F and Dahamna, Badisse and Darmoni, St{\'e}fan J},
  title = {ECMT : Indexation multi-terminologique de documents biom{\'e}dicaux},
  booktitle = {1er Forum Franco-Qu{\'e}b{\'e}cois d'Innovation en Sant{\'e}, Polytechnique Montr{\'e}al},
  year = {2016}
}

BibTeX:
@inproceedings{Henry2016,
  author = {Henry, V and Soualmia, LF and Grosjean, J and Desfeux, A and Darmoni, SJ and Gonzalez, B},
  title = {OMIConto : une Ressource Termino-Ontologique pour la Qualification et l’Indexation des Outils d’Analyse en Sciences Omiques},
  booktitle = {Actes du 2ème Atelier Intelligence Artificielle \& Santé@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  pages = {43-50},
  url = {https://ic2016.sciencesconf.org/conference/ic2016/pages/IA_Sante.pdf}
}

Abstract: Objectif L’objectif de notre étude était de montrer la faisabilité
du recueil de données et de montrer des exemples d’utilisation en
décrivant les principaux motifs de recours ainsi que les principales
classes thérapeutiques prescrites. Méthode Nous avons utilisé les
enregistrements médicaux électroniques (consultations de 2012 à 2015)
de 11 médecins généralistes volontaires recrutés parmi les maîtres
de stage du département de médecine générale de l’université de Nice
Sophia-Antipolis. Certains motifs de consultation ont été codés par
les médecins en utilisant la CISP-2. Les motifs restants ont été
codés a posteriori en utilisant l’extracteur de concepts multiterminologique
(ECMT) développé par l’équipe CISMeF. Résultats Sur 174 212 consultations,
103 571 motifs de consultations ont été renseignés (soit 0,59 motifs
par consultation) ; 16 224 (15,7  comportent un code CISP2 renseigné
par le médecin et 6875 motifs ont été codés a posteriori aboutissant
à un total de 80 099 motifs codés (77,3 .
BibTeX:
@article{Lacroix-Hugues2016,
  author = {Lacroix-Hugues, V. and Darmon, D. and Schuers, M. and Touboul, P. and Pradier, C.},
  title = {Création d’une base de données en médecine générale – projet pilote {PRIMEGE} {PACA}},
  month = {December},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2016},
  series = {8e {Colloque} de {Données} de santé en vie réelle, {Paris}, 2 juin 2016},
  volume = {64, Supplement 6},
  pages = {S301},
  url = {http://www.sciencedirect.com/science/article/pii/S0398762016307374},
  doi = {10.1016/j.respe.2016.10.032}
}

BibTeX:
@inproceedings{Mary2016,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Interopérabilité Sémantique dans le Domaine du Diagnostic in vitro},
  booktitle = {Actes du 2ème Atelier Intelligence Artificielle \& Santé@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  note = {In press}
}

BibTeX:
@inproceedings{Mary2016a,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Évaluation de la Qualité des Liens Sémantiques entre Vocabulaires Contrôlés},
  booktitle = {Actes de l'Atelier SoWeDo (des Sources Ouvertes au Web de Données)@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  url = {https://ic2016.sciencesconf.org/conference/ic2016/pages/SoWeDo_V2.pdf}
}

BibTeX:
@inproceedings{Mary2016d,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Projection des Propriétés d’une Ontologie pour la Classification d’une Ressource Terminologique},
  booktitle = {Actes des 6èmes Journées Francophones sur les Ontologies (JFO)},
  address = {Bordeaux, France},
  year = {2016},
  note = {in press.}
}

BibTeX:
@inproceedings{Siedlecki2016,
  author = {Clémence Siedlecki and Nicolas Griffon and Gaétan Kerdelhué and Julien Grosjean and Benoit Thirion and Marc Jamoulle and Stéfan Darmoni and Matthieu Schuers},
  title = {Thèmes et tendances de recherche en médecine générale : analyse de la littérature extraite de PubMed},
  booktitle = {Congrès du CNGE},
  year = {2016}
}

BibTeX:
@inproceedings{Griffon2016,
  author = {Griffon, N and Rollin, L and Schuers, M and Dhombres, F and Loiseau, S and Douze, L and Marcilly, R and Chabot, O and Delerue, D and Dutoit, D and Dahamna, B and Kerdelhué, G and Grosjean, J and Gehanno, JF and Darmoni, SJ},
  title = {Une base de données bibliographiques en français pour la Littérature Scientifique en Santé : LiSSa},
  booktitle = {JFIM},
  year = {2016}
}

BibTeX:
@inproceedings{Kerdelhue2016,
  author = {Kerdelhué, G and Grosjean, J},
  title = {A tool to design complex bibliographic queries in your own language},
  booktitle = {EAHIL},
  year = {2016}
}

BibTeX:
@inproceedings{Mary2016b,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Interopérabilité Sémantique dans le Domaine du Diagnostic in vitro : Évaluation d’Algorithmes sur LOINC et l’Ontologie SNOMED CT},
  booktitle = {Actes des 27èmes Journées Francophones d'Ingénierie des Connaissances (IC)},
  address = {Montpellier, France},
  year = {2016}
}

BibTeX:
@inproceedings{Mary2016e,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Usability and Improvement of Existing Alignments: the LOINC-SNOMED CT Case Study},
  booktitle = {20th International Conference on Knowledge Engineering and Knowledge Management, EKAW},
  address = {Bologna, Italy},
  year = {2016}
}

BibTeX:
@phdthesis{Chebil2016,
  author = {Wiem Chebil},
  title = {Indexation de documents médicaux avec un réseau possibiliste},
  school = {Université de Monastir},
  year = {2016}
}

2015


Abstract: Objectives: An important barrier to electronic healthcare information
exchanges (HIE) is the lack of interoperability between information
systems especially on the semantic level. In the scope of the ANR
(Agence Nationale pour la Recherche)/TeRSan (Terminology and Data
Elements Repositories for Healthcare Interoperability) project, we
propose to set and use a semantic interoperability platform, based
on semantic web technologies, in order to facilitate standardized
healthcare information exchanges between heterogeneous Electronic
Healthcare Records (EHRs) in different care settings.

Material and methods: The platform is a standard-based expressive
and scalable semantic interoperability framework. It includes centrally
managed Common Data Elements bounded to international/national reference
terminologies such as ICD10, CCAM, SNOMED CT, ICD-O, LOINC and PathLex.
It offers semantic services such as dynamic mappings between reference
and local terminologies.

Results: A pilot implementation of semantic services was developed
and evaluated within an HIE prototype in telepathology for remote
expert advice. The semantic services developed for transcoding local
terms into reference terms take into account the type of message
and the exchange context defined within standard-based integration
profiles.

Conclusion: The TeRSan platform is an innovative semantic interoperability
framework that (1) provides standard-based semantic services applicable
to any HIE infrastructure and (2) preserves the use of local terminologies
and local models by end users (health professionals' priority).
BibTeX:
@article{Aime2015,
  author = {Aimé, X. and Traore, L. and Chniti, A. and Sadou, E. and Ouagne, D. and Charlet, J. and Jaulent, M. -C. and Darmoni, S. and Griffon, N. and Amardeilh, F. and Bascarane, L. and Lepage, E. and Daniel, C.},
  title = {Semantic interoperability platform for {Healthcare} {Information} {Exchange}},
  month = {March},
  journal = {IRBM},
  year = {2015},
  series = {{ANR} {TECSAN} 2015},
  volume = {36},
  number = {2},
  pages = {62--69},
  url = {http://www.sciencedirect.com/science/article/pii/S195903181500024X},
  doi = {10.1016/j.irbm.2015.01.003}
}

Abstract: To summarize the best papers in the field of Knowledge Representation
and Management (KRM).A comprehensive review of medical informatics
literature was performed to select some of the most interesting papers
of KRM published in 2014.Four articles were selected, two focused
on annotation and information retrieval using an ontology. The two
others focused mainly on ontologies, one dealing with the usage of
a temporal ontology in order to analyze the content of narrative
document, one describing a methodology for building multilingual
ontologies.Semantic models began to show their efficiency, coupled
with annotation tools.
BibTeX:
@article{Charlet2015,
  author = {Charlet, J. and Darmoni, S. J.},
  title = {Knowledge Representation and Management. From Ontology to Annotation. Findings from the Yearbook 2015 Section on Knowledge Representation and Management.},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = {Dr Jean Charlet, LIMICS - INSERM U1142, Campus des Cordeliers, 15, rue de l'école de médecine, 75006 Paris, France, Tél. +33 1 44 27 91 09, E-mail: Jean.Charlet@upmc.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {134--136},
  url = {http://dx.doi.org/10.15265/IY-2015-038},
  doi = {10.15265/IY-2015-038}
}

Abstract: Objective: This part II article about the ‘words of prevention’ presents
in a terminological way the content of ten current concepts used
in the prevention domain which are closely linked to quaternary prevention:
(1) overinformation, (2) overdiagnosis, (3) medically unexplained
symptoms, (4) overmedicalisation, (5) incidentaloma, (6) overscreening,
(7) overtreatment, (8) shared decision making, (9) deprescribing,
and (10) disease mongering. Methods: with the support of the laboratory
team of the University of Rouen, France, which is dedicated to medical
terminology and semantic relationships, it was possible to utilize
a graphic user interface (called DBGUI) allowing the construction
of links for each of chosen terms, and making automatic links to
MeSH, if any. Those concepts are analyzed in their environment in
current literature, as well as in their MeSH counterparts, if any,
and related semantic online terminologies. Results and Discussion:
The rules in terminological development aspire to cover the whole
field of a concept and in the meantime, it helps to avoid the noise
due to proxy and not exactly related issues. This refers to exhaustivity
and specificity in information retrieval. Our finds show that referring
to MeSH only in information retrieval in General Practice/Family
medicine can induce much noise and poor adequacy to the subject investigated.
Conclusion: Gathering concepts in specially prepared terminologies
for further development of ontologies is a necessity to enter in
the semantic web area and the era of distributed data.
BibTeX:
@article{Jamoulle2015,
  author = {Jamoulle, Marc and Gavilan, Enrique and Cardoso, Raquel Val and Mariño, Maria Ana and Pizzanelli, Miguel and Grosjean, Julien and Darmoni, Stefan},
  title = {The words of prevention, part {II}: ten terms in the realm of quaternary prevention},
  month = {April},
  journal = {Revista Brasileira de Medicina de Família e Comunidade},
  year = {2015},
  volume = {10},
  number = {35},
  pages = {1-11},
  url = {http://orbi.ulg.ac.be/handle/2268/176757},
  doi = {10.5712/rbmfc10(35)1063}
}

Abstract: New tools in data management have emerged in the last decade, which
are going to revolutionize electronic health records and health information
systems. Family practitioners are the first, main and continuous
contact with the patient. They are the source and endpoint of the
circle of information, generated by judicious medical documentation
and smart secondary use of medical data. This article is an introduction
to health terminologies, ontologies, semantic data, and linked open
data, all expressions used by computer scientists, preparing themselves
for the next step: semantic web for health care data.
BibTeX:
@article{Jamoulle2015b,
  author = {Jamoulle, Marc and Stichele, Vander and H, Robert and Cardillo, Elena and Roumier, Joseph and Grosjean, Julien and Darmoni, Stefan},
  title = {Semantic {Web} and the {Future} of {Health} {Care} {Data} in {Family} {Practice}},
  month = {December},
  journal = {Merit Research Journal of Medicine and Medical Sciences},
  year = {2015},
  volume = {3},
  number = {12},
  pages = {586-594},
  url = {http://orbi.ulg.ac.be/handle/2268/189292}
}

Abstract: Systemic sclerosis (SSc) has a complex pathogenesis. Although, there
is a growing evidence that environmental factors have an impact on
alterations and modulation of epigenetic determinants, resulting
in SSc onset and progression. A marked correlation has thus been
found between SSc onset and occupational exposure to crystalline
silica and the following organic solvents: white spirit, aromatic
solvents, chlorinated solvents, trichloroethylene, and ketones; the
risk associated with high cumulative exposure to silica and organic
solvents further appears to be strongly increased in SSc. Altogether,
occupational exposure should be systematically checked in all SSc
patients at diagnosis, as (1) exposed patients seem to develop more
severe forms of SSc and (2) the identification of the occupational
agents will allow its interruption, which may lead to potential improvement
of SSc outcome. By contrast, based on current published data, there
is insufficient evidence that exposure to other chemical agents (including
notably pesticides as well as personal care such as silicone and
hair dye), physical agents (ionizing radiation, ultraviolet radiation,
electric and magnetic fields), and biological agents (infections
and diet, foods, and dietary contaminants) is a causative factor
of SSc. Further investigations are still warranted to identify other
environmental factors that may be associated with SSc onset and progression.
BibTeX:
@article{Marie2015a,
  author = {Marie, Isabelle and Gehanno, Jean-Francois},
  title = {Environmental risk factors of systemic sclerosis.},
  month = {September},
  journal = {Seminars in immunopathology},
  year = {2015},
  volume = {37},
  number = {5},
  pages = {463--473},
  doi = {10.1007/s00281-015-0507-3}
}

Abstract: BACKGROUND: Occupational exposure is reported as playing a substantial
causative role in systemic sclerosis (SSc). OBJECTIVE: We sought
to compare the characteristics of SSc in patients with and without
occupational exposure to crystalline silica/solvents. METHODS: In
all, 142 patients with SSc were enrolled in this prospective study.
An expert committee performed blind evaluation of occupational exposure
to crystalline silica/solvents. RESULTS: Patients exposed to crystalline
silica more often exhibited: diffuse cutaneous SSc (P = .02), digital
ulcers (P = .05), interstitial lung disease (P = .0004), myocardial
dysfunction (P = .006), and cancer (P = .06). Patients exposed to
solvents more frequently developed: diffuse cutaneous SSc (P = .001),
digital ulcers (P = .01), interstitial lung disease (P = .02), myocardial
dysfunction (P = .04), and cancer (P = .003); in addition, these
patients were more frequently anti-Scl 70 positive and anticentromere
negative. Under multivariate analysis, significant factors for SSc
associated with exposure to silica/solvents were: male gender (odds
ratio 19.31, 95% confidence interval 15.34-69.86), cancer (odds
ratio 5.97, 95% confidence interval 1.55-23.01), and digital ulcers
(odds ratio 2.42, 95% confidence interval 1.05-5.56). LIMITATIONS:
The cohort originated from a single geographic region. CONCLUSION:
Occupational exposure to crystalline silica/solvents is correlated
with more severe forms of SSc characterized by: diffuse cutaneous
involvement, interstitial lung disease, general microangiopathy (digital
ulcers and myocardial dysfunction), and association with cancer.
Occupational exposure should be systematically checked in all patients
with SSc, as exposed patients seem to develop more severe forms of
SSc.
BibTeX:
@article{Marie2015,
  author = {Marie, Isabelle and Menard, Jean-Francois and Duval-Modeste, Anne-Benedicte and Joly, Pascal and Dominique, Stephane and Bravard, Pierre and Noel, David and Gehanno, Jean-Francois and Bubenheim, Michael and Benichou, Jacques and Levesque, Herve},
  title = {Association of occupational exposure with features of systemic sclerosis.},
  month = {March},
  journal = {Journal of the American Academy of Dermatology},
  year = {2015},
  volume = {72},
  number = {3},
  pages = {456--464},
  doi = {10.1016/j.jaad.2014.11.027}
}

Abstract: Though there are common variations of the internal jugular vein (IJV),
fenestrations are extremely rare. The lateral branch of the accessory
nerve classically goes through the fenestration. We report a case
of an empty fenestration of the IJV that was discovered during clearance
of cervical lymph nodes. Original operative and radiographic images
are shown.
BibTeX:
@article{Pegot2015,
  author = {Pegot, Alexandre and Guichard, Benjamin and Peron, Jean-Marc and Trost, Olivier},
  title = {Empty fenestration of the internal jugular vein: a rare phenomenon.},
  month = {January},
  journal = {The British journal of oral \& maxillofacial surgery},
  year = {2015},
  volume = {53},
  number = {1},
  pages = {78--80},
  doi = {10.1016/j.bjoms.2014.09.005}
}

BibTeX:
@article{Rollin2015,
  author = {Rollin, L and Griffon, N and Darmoni, SJ and Gehanno, JF},
  title = {Influence of author's affiliation and funding sources on the results of cohort studies on occupational cancer},
  month = {March},
  journal = {American Journal of Industrial Medicine},
  year = {2015},
  volume = {59},
  number = {3},
  pages = {221–226},
  doi = {10.1002/ajim.22549}
}

Abstract: To summarize excellent current research in the field of Bioinformatics
and Translational Informatics with application in the health domain
and clinical care.We provide a synopsis of the articles selected
for the IMIA Yearbook 2015, from which we attempt to derive a synthetic
overview of current and future activities in the field. As last year,
a first step of selection was performed by querying MEDLINE with
a list of MeSH descriptors completed by a list of terms adapted to
the section. Each section editor has evaluated separately the set
of 1,594 articles and the evaluation results were merged for retaining
15 articles for peer-review.The selection and evaluation process
of this Yearbook's section on Bioinformatics and Translational Informatics
yielded four excellent articles regarding data management and genome
medicine that are mainly tool-based papers. In the first article,
the authors present PPISURV a tool for uncovering the role of specific
genes in cancer survival outcome. The second article describes the
classifier PredictSNP which combines six performing tools for predicting
disease-related mutations. In the third article, by presenting a
high-coverage map of the human proteome using high resolution mass
spectrometry, the authors highlight the need for using mass spectrometry
to complement genome annotation. The fourth article is also related
to patient survival and decision support. The authors present datamining
methods of large-scale datasets of past transplants. The objective
is to identify chances of survival.The current research activities
still attest the continuous convergence of Bioinformatics and Medical
Informatics, with a focus this year on dedicated tools and methods
to advance clinical care. Indeed, there is a need for powerful tools
for managing and interpreting complex, large-scale genomic and biological
datasets, but also a need for user-friendly tools developed for the
clinicians in their daily practice. All the recent research and development
efforts contribute to the challenge of impacting clinically the obtained
results towards a personalized medicine.
BibTeX:
@article{Soualmia2015b,
  author = {Soualmia, L. F. and Lecroq, T.},
  title = {Bioinformatics Methods and Tools to Advance Clinical Care. Findings from the Yearbook 2015 Section on Bioinformatics and Translational Informatics.},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = {Health, 1, rue de Germont, Cour Leschevin porte 21, 76031 Rouen Cedex, France, Tel : +33 232 885 869, E-mail: Lina.Soualmia@chu-rouen.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {170--173},
  url = {http://dx.doi.org/10.15265/IY-2015-026},
  doi = {10.15265/IY-2015-026}
}

BibTeX:
@article{Toubiana2015,
  author = {Toubiana, L. and Griffon, N.},
  title = {Modelling, Simulation and Social Network Data: What's New for Public Health and Epidemiology Informatics?},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = {, 15, rue de l'École de Médecine, 75006 Paris, France, Tel: +33 1 44 27 91 97, E-mail: Laurent.toubiana@inserm.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {216--219},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587051/pdf/ymi-10-0216.pdf},
  doi = {10.15265/IY-2015-031}
}

Abstract: In April 2013, the Strategic Advisory Group of Experts (SAGE) on immunization stated that a single dose of yellow fever (YF) vaccine is sufficient in the general population to confer a lifelong protection against YF. When the period of validity of the International Certificate of Vaccination (ICV) will be extended to a lifetime in June 2016, no booster dose will be needed. The objective of this prospective study was to determine the potential impact of the SAGE recommendations on the vaccination activity of our travel clinics. We showed that among 1,037 subjects seen in our three travel clinics for a YF vaccination in 2013, about 32.3% went for a booster dose that is no longer useful according to the SAGE. A drop in vaccination activity has to be expected by travel clinics in the next years, and changes in daily exercise have to be anticipated, as YF vaccination is a large part of the regular work of many healthcare providers specialized in travel medicine.
BibTeX:
@article{Wyplosz2015,
  author = {Wyplosz, Benjamin and Leroy, Jean-Philippe and Derradji, Ouda and Consigny, Paul-Henri},
  title = {No booster dose for yellow fever vaccination: what are the consequences for the activity of vaccination in travel clinics?},
  journal = {Journal of travel medicine},
  year = {2015},
  volume = {22},
  pages = {140--141},
  doi = {10.1111/jtm.12173}
}

Abstract: Intérêts de la spirométrie en soins primairesLa spirométrie est une
exploration de la fonction respiratoire réalisable en cabinet de
médecine générale. Elle permet de diagnostiquer un trouble ventilatoire
obstructif (TVO), de mesurer sa sévérité et de suivre son évolution
avec ou sans traitement. Elle donne également des arguments en faveur
d’un trouble ventilatoire restrictif (TVR) permettant de proposer
des explorations spécialisées complémentaires. Les professionnels
de santé de soins primaires utilisent la spirométrie principalement
pour le diagnostic et le suivi de l’asthme et de la bronchopneumopathie
chronique obstructive (BPCO). La spirométrie fait partie de la démarche
diagnostique face à un patient symptomatique (toux ou expectoration
chroniques, dyspnée, sibilants).Asthme et BPCO : deux maladies prévalentes
En France, 9 % des enfants et 6 % des adultes sont asthmatiques1.
Diagnostiquer l’asthme permet d’instaurer le traitement médicamenteux
recommandé afin d’améliorer les symptômes, la qualité de vie, la
fréquence des exacerbations et la mortalité2.
BibTeX:
@article{Bouchez2015,
  author = {Bouchez, T and Chapron, A and Guihard, H and Thebault, JL and Schuers, M. and Darmon, D},
  title = {La spirométrie en cabinet de médecine générale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {120},
  pages = {176--81}
}

BibTeX:
@article{Crampon2015,
  author = {Crampon, F. and Eliezer, M. and Choussy, O. and Hardy, H. and Trost, O.},
  title = {A pathognomonic {CT} of the parotid gland.},
  month = {February},
  journal = {Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale},
  year = {2015},
  volume = {116},
  number = {1},
  pages = {e1--2},
  doi = {10.1016/j.revsto.2014.10.001}
}

Abstract: L’objectif attribué par la loi aux services de santé au travail est
d’éviter toute altération de la santé des travailleurs du fait de
leur travail mais également de contribuer au maintien dans l’emploi
des travailleurs. À cette fin, les services de santé au travail conduisent,
entre autres, des actions de surveillance systématique de la santé,
dans une optique de dépistage pour des pathologies en lien avec le
travail ou pouvant avoir un retentissement sur le travail. Nous laisserons
de côté la surveillance médicale renforcée, qui fait l’objet de recommandations
spécifiques. Dans le cadre d’un suivi de santé non motivé par une
exposition à des facteurs de risques professionnels, la question
posée est celle de l’intérêt d’un examen clinique régulier, assorti
ou non d’examens paracliniques. Si la littérature est limitée dans
le domaine de la santé au travail, elle est abondante dans le champ
de la santé publique et permet d’affirmer que ce type de suivi systématique
n’apporte pas de bénéfice mesurable en termes de limitation de la
mortalité ou de la morbidité, globale, cardiovasculaire ou par cancer
[1] . Il n’est de plus pas dénué d’effets secondaires, auxquels il
faut ajouter le risque d’exclusion propre à la santé au travail.
Il convient toutefois de souligner que l’intérêt de ce type de rendez-vous
de santé régulier n’a pas été évalué en termes de maintien de la
relation, ou de la confiance, entre le patient/salarié et le médecin.
L’intérêt d’un dépistage étant lié à la fréquence de la maladie dans
la population qui bénéficie du dépistage, il peut être plus important
dans certains groupes exposés à des nuisances professionnelles. On
peut ainsi citer deux exemples ayant fait l’objet de recommandations
récentes de la part de la Société française de médecine du travail.
Chez les sujets exposés à des allergènes, il est recommandé de procéder
au dépistage de la rhinite professionnelle en particulier pendant
l’apprentissage ou les deux premières années d’exposition [2] . Chez
les travailleurs postés et/ou de nuit, il est recommandé de dépister
une privation chronique de sommeil et des épisodes de somnolence
ainsi que de mesurer le poids et la tension de façon annuelle [3]
. Il est intéressant de noter que ces dépistages reposent principalement
sur l’interrogatoire, et peuvent donc impliquer l’infirmier de santé
au travail. Le rendez-vous de santé servant de support au dépistage
peut également être l’occasion d’une information sur les risques
professionnels, comme cela a été proposé récemment chez les salariés
exposés à de la manutention manuelle de charges [4] . Enfin, la notion
de dépistage peut également être élargie aux conditions de travail
et aux expositio...
BibTeX:
@article{Gehanno2015,
  author = {Gehanno, J.F. and Larchevesque, J.Y.},
  title = {État des connaissances sur les dépistages en santé au travail},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2015},
  volume = {76},
  number = {4},
  pages = {407--407},
  doi = {10.1016/j.admp.2015.04.042}
}

Abstract: Contexte. Depuis 2007, 130 chefs de clinique de médecine générale
ont été nommés et 13 d’entre eux sont devenus maîtres de conférences
des universités par la voie du concours. La création de la soussection
53-03 propre à la médecine générale en mars 2015 paraissait une occasion
pertinente de décrire l’activité des chefs de clinique.Objectif.
Décrire les activités de soins, d’enseignement et de recherche des
chefs de clinique de médecine générale en activité en octobre 2014.Méthode.
Enquête descriptive par questionnaire auto-administré en ligne. Les
activités de soins, d’enseignement et de recherche ont été décrites
: organisation, contenu, formation, satisfaction et perspectives.Résultats.
Parmi les 95 chefs de clinique de médecine générale en poste à la
date de l’étude, 75 (79 ont répondu : âge moyen 32 ans ; sex-ratio
F/H 2,4. Ils consacraient respectivement un nombre médian de 5, 2
et 3 demi-journées par semaine aux activités de soins, d’enseignement
et de recherche. L’activité de soins était majoritairement libérale
(73 – dont 39 % en structure pluriprofessionnelle – à raison
de 50 consultations par semaine. Le nombre de patients les ayant
déclarés médecin traitant augmentait significativement au cours du
clinicat. L’activité d’enseignement concernait surtout le troisième
cycle (médiane : 86 heures par an). Un tiers des chefs de clinique
étaient maîtres de stage des universités. L’activité de recherche
augmentait significativement au cours du clinicat. La majorité des
chefs de clinique avaient une formation à la recherche et un projet
en cours (45 % au sein d’une unité labellisée). Les thématiques
de recherche étaient en rapport avec le champ disciplinaire.Conclusion.
Au cours du clinicat, la stabilisation – voire le renforcement –
des activités de soins et de recherche s’accompagne d’un investissement
marqué dans l’activité d’enseignement. Cette dynamique doit se poursuivre,
pour un rôle de plus en plus modélisant de l’enseignant-chercheur
en médecine générale.
BibTeX:
@article{Laporte2015,
  author = {Laporte, C. and Barais, M and Bouchez, T and Darmon, D and Dibao-Dina, C. and Frappé, P. and Saint-Lary, O. and Schuers, M. and Gelly, J.},
  title = {Activité des chefs de clinique en médecine générale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {122},
  pages = {283--94}
}

BibTeX:
@article{Leroy2015,
  author = {Leroy, Jean-Philippe},
  title = {Vaccin contre la fièvre jaune : une protection à vie ?},
  month = {October},
  journal = {La Revue du praticien},
  year = {2015},
  volume = {65},
  pages = {1015--1017}
}

Abstract: Dans le domaine de la santé au travail, de très nombreuses situations
sont à l’origine de conflits éthiques. À titre d’exemple, les adaptations
ou les maintiens dans l’emploi pour des problèmes de santé font intervenir
non seulement les employeurs et leurs employés mais également les
médecins du travail dont les déterminations d’aptitude médicale au
poste ont des conséquences socioprofessionnelles majeures. Si on
remonte à sa création, depuis 1946, la réglementation française relative
à la santé au travail a fait l’objet de multiples modifications.
À ce titre, en 2012, une nouvelle réforme de la médecine du travail
a été à l’origine d’une réapparition de questionnements de pratiques
chez les personnes impliquées par ces changements. Aussi, par l’intermédiaire
d’un recueil de situations réelles, nous avons voulu apporter un
regard pluridisciplinaire sur les dilemmes éthiques encore plus mis
en lumière par cette évolution réglementaire dans un monde du travail
qui traverse actuellement une période économique tendue.
BibTeX:
@article{Lodde2015,
  author = {Loddé, B. and Gehanno, J.-F. and Jousset, D. and Pougnet, R. and Durand-Moreau, Q. and Dewitte, J.-D.},
  title = {Conflits éthiques en {Santé} au {Travail} : quelques particularités de la réglementation française opposées à des difficultés pratiques de mises en œuvre},
  journal = {Ethique et Sante},
  year = {2015},
  volume = {12},
  number = {2},
  pages = {138--144},
  doi = {10.1016/j.etiqe.2014.12.001}
}

Abstract: Il n’existe pas à l’heure actuelle de réel consensus concernant les
modalités du dépistage du risque de mort subite d’origine cardiovasculaire
chez les sportifs de moins de 35 ans. La question de l’adjonction
systématique d’un électrocardiogramme fait notamment débat. D’un
côté, l’électrocardiogramme vient apporter de la validité à un examen
physique qui en manque cruellement. L’expérience italienne, la plus
connue, montre aussi des résultats spectaculaires. Entre 1979 et
2004, l’incidence des morts subites chez les sportifs a chuté de
près de 90 %. D’un autre côté, l’incidence des morts subites chez
les jeunes sportifs en France est très faible, de l’ordre de 0,5
à 1 cas pour 100 000 personnes par an, soit moins de 50 cas annuels.
De plus, la réalisation systématique d’un ECG, même interprété par
un professionnel expérimenté, expose à un taux significatif de faux
positifs. Cette faible spécificité n’est pas sans conséquences pour
le patient. Enfin, l’implémentation d’un programme de dépistage systématique
du risque de mort subite par électrocardiogramme en France engendrerait
des coûts majeurs, en termes d’équipement, de formation des professionnels
et d’honoraires. À ce jour, il ne semble pas exister suffisamment
de données permettant de justifier l’ajout systématique de l’ECG
à la procédure de dépistage du risque de mort subite chez le jeune
sportif.
BibTeX:
@article{Quibel2015,
  author = {Quibel, T and Valy, G and Schuers, M.},
  title = {Dépistage du risque de mort subite chez le sportif : quelle place pour l’{ECG} ?},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {119},
  pages = {77--82}
}

Abstract: Contexte Afin d’aider les patients atteints de cancer à reprendre
le travail, une plateforme multidisciplinaire médico-socio-psychologique
d’aide à la reprise du travail après un cancer a été créée en 2006 en
Haute-Normandie. Objectifs Décrire l’organisation et les retours
de cette plateforme. Méthode Les 3 intervenants ont fait part de
leurs observations. Les caractéristiques des consultants, les conseils
apportés et le devenir des patients ont été analysés via l’étude
des dossiers et un questionnaire complété par le patient. Résultats
Cent cinquante patients, atteints principalement de cancer du sein
(64 , ont consulté pour des problématiques de maintien dans l’emploi
(3/4) ou de recherche d’emploi (1/4). Le taux de reprise, évalué
à partir de questionnaires adressés aux patients en 2011, était de
64 % (IC 95 % = 54–73), en moyenne 7 mois (IC 95 % = 5–9) après
la 1 re  consultation de reprise du travail. Quatre-vingt-treize
pour cent des patients estimaient que la plateforme leur avait été
utile. Cette plateforme permet une transition entre les milieux de
soins et du travail, oriente le patient vers le bon interlocuteur
compte tenu de la situation et apporte des conseils spécifiques adaptés
à la pathologie ainsi qu’un avis spécialisé à des patients n’en bénéficiant
pas habituellement.
BibTeX:
@article{Rollin2015a,
  author = {Rollin, Lætitia and De Blasi, Géraldine and Boucher, Line and Gehanno, Jean-François},
  title = {Intérêts d’une consultation spécialisée d’aide à la reprise du travail après cancer},
  journal = {Bulletin du cancer},
  year = {2015},
  volume = {102},
  number = {2},
  pages = {182--189},
  doi = {10.1016/j.bulcan.2014.06.001}
}

BibTeX:
@inproceedings{Cabot2015a,
  author = {Cabot, Chlo{\'e} and Soualmia, Lina F and Grosjean, Julien and Lelong, Romain and Darmoni, St{\'e}fan J},
  title = {Integrating and Retrieving Clinical and Omic Data in Electronic Health Records},
  booktitle = {7th International Workshop on Knowledge Representation for Health Care (KRH4C) and 8th International Workshop on Process-oriented Information Systems in Healthcare (ProHealth)},
  year = {2015},
  pages = {154-159},
  url = {https://www.researchgate.net/profile/Lina_Soualmia/publication/280066101_Integrating_and_Retrieving_Clinical_and_Omic_Data_in_Electronic_Health_Records/links/55a7a47408aeceb8cad65695.pdf}
}

BibTeX:
@inproceedings{Chebil2015,
  author = {Chebil, W and Soualmia, LF and Omri, MN and Darmoni, SJ},
  title = {Biomedical Concepts Extraction with a Possibilistic Network and a Vector Space Model},
  booktitle = {15th Conference on Artificial Intelligence in MEdicine, AIME'15},
  year = {2015},
  series = {Lecture Notes in Artificial Intelligence},
  volume = {9105},
  pages = {227-231},
  doi = {10.1007/978-3-319-19551-3_29}
}

Abstract: The use of watermarking in the protection of medical relational databases
requires that the introduced distortion does not hinder records interpretation.
In this paper, we present the preliminary results of a watermarked
data quality evaluation protocol developed so as to analyze the perception
the practitioner has of the watermark. These results show that some
attributes are more appropriate for watermarking than others and
also that incoherent or unlikely records resulting from careless
watermarking are easily identified by an expert.
BibTeX:
@inproceedings{Franco-Contreras2015,
  author = {Franco-Contreras, Javier and Coatrieux, Gouenou and Massari, Philippe and Darmoni, Stefan and Cuppens-Boulahia, Nora and Cuppens, Frédéric and Roux, Christian},
  title = {Data quality evaluation in medical database watermarking.},
  booktitle = {MIE 2015},
  journal = {Stud Health Technol Inform},
  school = {Institut Mines-TELECOM, Mines Saint-Étienne, Saint-Étienne, 62362 France.},
  year = {2015},
  volume = {210},
  pages = {276--280}
}

BibTeX:
@inproceedings{Grouin2015a,
  author = {Grouin, C and Griffon, N and Névéol, A},
  title = {Is it possible to recover personal health information from an automatically de-identified corpus of French EHRs?},
  booktitle = {Proc of LOUHI - the Sixth International Workshop on Health Text Mining and Information Analysis},
  address = {Lisbon, Portugal},
  year = {2015}
}

Abstract: Suspected adverse drug reactions (ADR) reported by patients through
social media can be a complementary tool to already existing ADRs
signal detection processes. However, several studies have shown that
the quality of medical information published online varies drastically
whatever the health topic addressed. The aim of this study is to
use an existing rating tool on a set of social network web sites
in order to assess the capabilities of these tools to guide experts
for selecting the most adapted social network web site to mine ADRs.First,
we reviewed and rated 132 Internet forums and social networks according
to three major criteria: the number of visits, the notoriety of the
forum and the number of messages posted in relation with health and
drug therapy. Second, the pharmacist reviewed the topic-oriented
message boards with a small number of drug names to ensure that they
were not off topic. Six experts have been chosen to assess the selected
internet forums using a French scoring tool: Net scoring. Three different
scores and the agreement between experts according to each set of
scores using weighted kappa pooled using mean have been computed.Three
internet forums were chosen at the end of the selection step. Some
criteria get high score (scores 3-4) no matter the website evaluated
like accessibility (45-46) or design (34-36), at the opposite some
criteria always have bad scores like quantitative (40-42) and ethical
aspect (43-44), hyperlinks actualization (30-33). Kappa were positives
but very small which corresponds to a weak agreement between experts.The
personal opinion of the expert seems to have a major impact, undermining
the relevance of the criterion. Our future work is to collect results
given by this evaluation grid and proposes a new scoring tool for
Internet social networks assessment.
BibTeX:
@inproceedings{Katsahian2015,
  author = {Katsahian, Sandrine and {Simond Moreau}, Erica and Leprovost, Damien and Lardon, Jeremy and Bousquet, Cedric and Kerdelhué, Gaétan and Abdellaoui, Redhouane and Texier, Nathalie and Burgun, Anita and Boussadi, Abdelali and Faviez, Carole},
  title = {Evaluation of Internet Social Networks using Net scoring Tool: A Case Study in Adverse Drug Reaction Mining.},
  booktitle = {MIE 2015},
  journal = {Stud Health Technol Inform},
  school = {Kappa Santé, Paris, France.},
  year = {2015},
  volume = {210},
  pages = {526--530}
}

BibTeX:
@inproceedings{Merabti2015,
  author = {Merabti, T and Lelong, R and Darmoni, SJ},
  title = {InfoRoute: the CISMeF Context-specific Search Algorithm},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {544-8}
}

Abstract: Consequences of the computerization of laboratory and radiology information
system (LIS and RIS) are not well documented. The aim of this study
was to evaluate the impact of computerization of LIS and RIS of four
hospitals on performance and quality of care. The study was divided
into three phases. First, the subprocesses and information flows
of LIS and RIS were described. Then, a literature review was performed
in order to identify the indicators used to assess the impact of
computerization. Finally, comparisons were made between 2 hospitals.
Using the initial framework, each partner described its process mapping
concerning LIS and RIS. The review identified a wide panel of indicators.
Only 41 were useful to assess the impact of information systems.
For each two by two comparison, lists of relevant indicators have
been selected from the identified indicators and according to the
process mapping comparison. Two by two comparisons have to be completed.
Eventually, these indicators may be integrated in the quality process
of hospital information systems.
BibTeX:
@inproceedings{Schuers2015a,
  author = {Schuers, M and Joulakian, M and Griffon, N and Pachéco, J and Périgard, C and Lepage, E and Watbled, L and Massari, P and Darmoni, SJ},
  title = {Quality indicators from laboratory and radiology information systems},
  booktitle = {MEDINFO},
  journal = {Studies in Health Technology and Informatics},
  year = {2015},
  volume = {216},
  pages = {212-6},
  note = {PREPS EVAL-SI},
  doi = {10.3233/978-1-61499-564-7-212}
}

BibTeX:
@inproceedings{Soualmia2015a,
  author = {Soualmia, LF and Cabot, C and Dahamna, B and Darmoni, SJ},
  title = {SIBM at CLEF e-Health Evaluation Lab 2015},
  booktitle = {proceedings of CLEF 2015 - Conference and Labs of the Evaluation Forum},
  year = {2015},
  series = {CEUR Workshop Proceedings},
  volume = {1391},
  url = {http://ceur-ws.org/Vol-1391/125-CR.pdf}
}

Abstract: In this paper, a method based on pre-defined patterns, which rewrites
natural language queries into a multi-layer, flexible, scalable and
object-oriented query language, is presented. The method has been
conceived to assist physicians in their search for clinical information
in an Electronic Health Records system. Indeed, the query language
of the system being difficult to handle for physicians, this method
allows querying using natural language vs. using dedicated object-oriented
query language. The information extraction method that has been developed
can be seen as a named entity recognition system based on regular
expressions that tags pieces of the query. The patterns are constructed
recursively from the initial natural language query and from atomic
patterns that correspond to the entities, the relationships and the
constraints of the underlying model representing Electronic Health
Records. Further evaluation is needed, but the preliminary results
obtained by testing a set of natural language queries are very encouraging.
BibTeX:
@inproceedings{Soualmia2015,
  author = {Soualmia, LF and Lelong, R and Dahamna, B and Darmoni, SJ},
  title = {Rewriting Natural Language Queries Using Patterns},
  booktitle = {proceedings of MRMD},
  publisher = {Springer-Verlag},
  year = {2015},
  series = {Lecture Notes in Computer Science},
  volume = {9059},
  pages = {40-53},
  doi = {10.1007/978-3-319-24471-6_4}
}

BibTeX:
@inproceedings{Cabot2015,
  author = {Cabot, C and Soualmia, LF and Darmoni, SJ},
  title = {Intégration de données cliniques et omiques pour la recherche d’information dans le Dossier Patient Informatisé},
  booktitle = {Actes des 26èmes Journées Francophones d’Ingénierie des Connaissances (IC), associées à la Plateforme de l’Association Française pour l’Intelligence Artificielle},
  address = {Rennes, France},
  year = {2015},
  pages = {183-193},
  url = {https://hal.archives-ouvertes.fr/hal-01179292/}
}

BibTeX:
@inproceedings{Grouin2015,
  author = {Grouin, C and Griffon, N and Névéol, A},
  title = {Étude des risques de réidentification des patients à partir d'un corpus désidentifié de comptes-rendus cliniques en français},
  booktitle = {Atelier ETeRNAL Ethique et TRaitemeNt Automatique des Langues},
  address = {Caen, France},
  month = {Juin},
  year = {2015},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/pdf/Giquel2013.pdf}
}

BibTeX:
@inproceedings{Lelong2015a,
  author = {Lelong, R and Cabot, C and Merabti, T and Grosjean, J and Joulakian, M and Griffon, N and Dahamna, B and Massari, P and Darmoni, SJ},
  title = {Information Retrieval in Electronic Health Records Using a Multiple Layer Query Language},
  booktitle = {RITS},
  year = {2015},
  note = {projet RAVEL ANR TecSan}
}

BibTeX:
@inproceedings{Gicquel2015,
  author = {Gicquel, Q and Tvardik, N and Bouvry, C and Kergourlay, I and Bittar, A and Segond, F and Darmoni, SJ and Metzger, MH},
  title = {Annotation methods to develop and evaluate an expert system based on natural langage processing in electronic medical records},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {1067},
  doi = {10.3233/978-1-61499-564-7-1067}
}

BibTeX:
@inproceedings{Henry2015,
  author = {Henry, V and Grosjean, J and Soualmia, LF and Bandrowski, A and Gonzalez, B and Darmoni, SJ and Desfeux, A},
  title = {OMIC-Onto : une ressource pour l'indexation et la recherche d'outils omiques},
  booktitle = {Actes des Journées Ouvertes en Bioinformatique, Informatique et Mathématiques (JOBIM)},
  address = {Clermont-Ferrand, France},
  month = {Juillet},
  year = {2015}
}

Abstract: ICPC is available in the HeTOP cross-lingual terminology portal (URL:
www.hetop.eu) [1] in 19 languages, mostly European (e.g. Spanish,
Portuguese) but also in Japanese or Mandarin. The HeTOP interface
has been also translated in 10 languages, including by Wonca colleagues
(in Turkish, Vietnamese and Romanian). This is very important for
non-English speakers to access a health Web site in his/her native
language. Thanks to a partial manual mapping between ICPC2 and MeSH,
it is now also possible to query PubMed from 20% of ICPC2 codes.
This task is time consuming as in lot of cases, the mapping is 1
to N (one ICPC code generates several MeSH terms; e.g. the ICPC term
"diverticular disease" is mapped to two MeSH terms " diverticulosis,
colonic" and " diverticulitis". HeTOP currently contains 56 health
terminologies and ontologies (only 17 are included in UMLS as most
of them are French terminologies), 1,951,834 concepts, 6,636,000
terms, 8,023,181 relations and 1,340,855 relations. Overall, HeTOP
contains 108 millions of SPARQL triplets. These figures underlines
the possible application of the so called "health big data". Overall,
the number of distinct UMLS concepts with at least one French translation
in UMLS (MeSH, MedDRA, WHOART, ICPC) is 45,405 vs. 317,539 in HeTOP.
1. Grosjean, J; Merabti, T; Griffon, N; Dahamna, B & Darmoni, SJ.
Teaching medicine with a terminology/ontology portal. Stud Health
Technol Inform 2012:180;949-53.
BibTeX:
@inproceedings{Jamoulle2015a,
  author = {Jamoulle, Marc and Pizzanelli, Miguel and Grosjean, Julien and Kerdelhue, Gaetan and Darmoni, Stefan},
  title = {International {Classification} of {Primary} {Care} in a cross-lingual terminology portal},
  month = {March},
  year = {2015},
  note = {Best Poster Award},
  url = {http://orbi.ulg.ac.be/handle/2268/179499}
}

BibTeX:
@inproceedings{Kerdelhue2015,
  author = {Kerdelhué, G and Grosjean, J and Darmoni, SJ \& le consortium du projet BDBfr},
  title = {LiSSa : Une nouvelle base de données de la littérature Scientifique en Santé en langue française},
  booktitle = {7ème journée ITS / 2ème journée innovation},
  address = {Montpellier, France},
  month = {Décembre},
  year = {2015},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2015/12/ITS_poster_2015_lissa.pdf}
}

BibTeX:
@inproceedings{Merabti2015a,
  author = {Merabti, T and Grosjean, J and Rodrigues, JM and Darmoni, SJ},
  title = {Translating ICD-11 into French using lexical-based approach: a preliminary study},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {1036}
}

BibTeX:
@inproceedings{Schuers2015,
  author = {Schuers, M},
  title = {Interroger Medline en français : c'est possible !},
  booktitle = {CMGF Paris},
  year = {2015}
}

BibTeX:
@inproceedings{Schuers2015b,
  author = {Schuers, M and Griffon, N and Kerdelhué, G and Grosjean, J and Darmoni, SJ},
  title = {Évaluation de l'association entre langue et qualité des requêtes pour la recherche bibliographique: essai randomisé},
  booktitle = {4ème journée de l'IRIB},
  address = {Rouen, France},
  year = {2015}
}

Abstract: Electronic medical records (EHR) are a very important source of information
for secondary use as epidemiological analysis and health services
evaluation. The normalisation of the medical terms extracted from
medical documents is an essential step of the preprocessing. Its
quality partly depends on the medical terminologies available in
the corresponding language. The objective of this presentation is
to highlight the terminology needs for optimizing the data analysis
of medical documents in the context of care pathway evaluation.
BibTeX:
@inproceedings{Tvardik2015,
  author = {Tvardik, N and Bouvry, C and Kergoulay, I and Darmoni, SJ and Metzger, M},
  title = {The terminology needs for evaluation of care pathways},
  booktitle = {WHO - family of international classifications network annual meeting 2015},
  month = {October},
  year = {2015}
}

Abstract: Studies on the impact of a Health Information Technology seldom consider
socio-technical characteristics of the work system in which the technology
is implemented. Yet those dimensions may act as hidden variables
that could explain the inconsistency of impact studies' results in
terms of performance, quality and satisfaction. This paper reports
on the identification of those variables in the discharge letter
(DL) process. Human Factors experts performed an analysis of the
work system of the DL process in 17 medical units. The DL process
is composed of three sub-processes running with work system differing
according to the distribution of tasks, the technology implemented
and the work organization. Hidden variables identified are: verification
by the physician, technology's integration, number of editing cycles,
physicians' preferences etc. Those variables can be collected automatically
or by questionnaire. Statistical analyses will have to be performed
to know which variable explain impact indicators.
BibTeX:
@article{Watbled2015,
  author = {Watbled, Ludivine and Beuscart-Zephir, Marie-Catherine and Guerlinger, Sandra and Douze, Laura and Lepage, Eric and Darmoni, Stéfan J. and Marcilly, Romaric},
  title = {Work System Characteristics Impacting the Performance and Quality of the Discharge Letter Process.},
  journal = {Stud Health Technol Inform},
  school = {INSERM CIC-IT 1403, Lille; Univ Lille Nord de France ; CHU Lille ; UDSL EA 2694 ; F-59000 Lille, France.},
  year = {2015},
  volume = {218},
  pages = {145--150},
  note = {PREPS EVAL-SI},
  doi = {10.3233/978-1-61499-574-6-145}
}

Abstract: Les connaissances dans le domaine de santé sont en constante évolution ainsi que les ressources qui permettent de les modéliser et les besoins utilisateurs pour lesquelles elles ont été construites. En effet, cette évolution rapide de ces connaissances requiert une mise à jour des documents médicaux correspondants ce qui a motivé beaucoup de travaux de recherche. L’objectif de ces travaux est de proposer une méthode de comparaison qui soit assez générique pour pouvoir étudier l’évolution entre deux versions d’un même document médical indépendamment de sa spécifité. Notre approche de comparaison est fondée sur l’extraction des syntagmes nominaux, les mesures de similarité et les alignements entre terminologies. Pour mieux mesurer ses avantages et ses limites, nous avons appliqué notre méthode sur deux types de documents médicaux différents : les documents relatifs aux maladies et plus précisément les maladies chroniques, dans lesquelles cette évolution joue un rôle capital où n’importe quel changement même minime impacte fortement leur suivi (les Recommandations de Bonne Pratique) et les documents sur les médicaments, pour connaitre par exemple les nouveaux changements des compositions des médicaments ou encore les nouveaux effets indésirables (les Résumés des Caractéristiques du Produit).
BibTeX:
@phdthesis{Merabti2015b,
  author = {Adila Amaria Merabti},
  title = {Représentation de l'évolution des connaissances : application au domaine biomédical},
  school = {Université de Rouen},
  year = {2015},
  url = {http://www.theses.fr/2015ROUES025}
}

2014


Abstract: This qualitative pilot exploratory study focuses on support groups
for vocational rehabilitation after cancer implemented in a French
and innovative multidisciplinary department of "Return to Work after
a Cancer." Sixty-three patients were invited to participate to constitute
two support groups of 20 participants. Questionnaires are sent to
assess their benefit according to the participants' point of view.
For 58% of participants, support groups helped the return to work,
and for 70% it provided personal, family, and relational support.
Support groups are a relevant response to expectations and specific
issues of patients experiencing return to work after cancer.
BibTeX:
@article{DeBlasi2014,
  author = {De Blasi, G. and Bouteyre, E. and Bretteville, J. and Boucher, L. and Rollin, L.},
  title = {Multidisciplinary department of "{Return} to {Work} {After} a {Cancer}": a {French} experience of support groups for vocational rehabilitation.},
  journal = {Journal of psychosocial oncology},
  year = {2014},
  volume = {32},
  number = {1},
  pages = {74--93},
  doi = {10.1080/07347332.2013.855961}
}

Abstract: To summarize the best papers in the field of Knowledge Representation
and Management (KRM).A comprehensive review of medical informatics
literature was performed to select some of the most interesting papers
of KRM and natural language processing (NLP) published in 2013.Four
articles were selected, one focuses on Electronic Health Record (EHR)
interoperability for clinical pathway personalization based on structured
data. The other three focus on NLP (corpus creation, de-identification,
and co-reference resolution) and highlight the increase in NLP tools
performances.NLP tools are close to being seriously concurrent to
humans in some annotation tasks. Their use could increase drastically
the amount of data usable for meaningful use of EHR.
BibTeX:
@article{Griffon2014c,
  author = {Griffon, N. and Charlet, J. and Darmoni, S. J.},
  title = {Managing free text for secondary use of health data.},
  journal = {Yearb Med Inform},
  year = {2014},
  volume = {9},
  number = {1},
  pages = {167--169},
  url = {http://dx.doi.org/10.15265/IY-2014-0037},
  doi = {10.15265/IY-2014-0037}
}

Abstract: BACKGROUND AND OBJECTIVE: Doc'CISMeF (DC) is a semantic search engine
used to find resources in CISMeF-BP, a quality controlled health
gateway, which gathers guidelines available on the internet in French.
Visualization of Concepts in Medicine (VCM) is an iconic language
that may ease information retrieval tasks. This study aimed to describe
the creation and evaluation of an interface integrating VCM in DC
in order to make this search engine much easier to use.

METHODS: Focus groups were organized to suggest ways to enhance information
retrieval tasks using VCM in DC. A VCM interface was created and
improved using the ergonomic evaluation approach. 20 physicians were
recruited to compare the VCM interface with the non-VCM one. Each
evaluator answered two different clinical scenarios in each interface.
The ability and time taken to select a relevant resource were recorded
and compared. A usability analysis was performed using the System
Usability Scale (SUS).

RESULTS: The VCM interface contains a filter based on icons, and icons
describing each resource according to focus group recommendations.
Some ergonomic issues were resolved before evaluation. Use of VCM
significantly increased the success of information retrieval tasks
(OR=11; 95% CI 1.4 to 507). Nonetheless, it took significantly more
time to find a relevant resource with VCM interface (101 vs 65 s;
p=0.02). SUS revealed 'good' usability with an average score of 74/100.

CONCLUSIONS: VCM was successfully implemented in DC as an option.
It increased the success rate of information retrieval tasks, despite
requiring slightly more time, and was well accepted by end-users.
BibTeX:
@article{Griffon2014a,
  author = {Griffon, N and Kerdelhué, G and Hamek, S and Hassler, S and Boog, C and Lamy, JB and Duclos, C and Venot, A and Darmoni, SJ},
  title = {Design and usability study of an iconic user interface to ease information retrieval of medical guidelines},
  month = {March},
  journal = {Journal of the American Medical Informatics Association},
  year = {2014},
  volume = {21},
  number = {e2},
  pages = {e270-277},
  doi = {10.1136/amiajnl-2012-001548}
}

BibTeX:
@article{Griffon2014,
  author = {Griffon, N and Kerdelhué, G and Soualmia, LF and Merabti, T and Grosjean, J and Lamy, JB and Venot, A and Duclos, C and Darmoni, SJ},
  title = {Evaluating alignment quality between iconic language and reference terminologies using similarity metrics},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2014},
  volume = {14},
  pages = {17},
  doi = {10.1186/1472-6947-14-17}
}

BibTeX:
@article{Griffon2014d,
  author = {Griffon, N and Schuers, M and Soualmia, LF and Grosjean, J and Kerdelhué, G and Kergoulay, I and Dahamna, B and Darmoni, SJ},
  title = {A Search Engine to Access PubMed Monolingual Subsets: Proof of Concept - Evaluation in French},
  month = {December},
  journal = {J Med Internet Res},
  year = {2014},
  volume = {16},
  number = {12},
  pages = {e271},
  doi = {doi:10.2196/jmir.3836}
}

Abstract: Anatomical variations of the stylohyoid apparatus are frequent. Two
types can occur: an elongation of the stylohyoid ligament, from a
long styloid process to a complete ossified structure connecting
the skull base to the lesser horn of the hyoid bone, or the existence
of supernumerary bones in the stylohyoid fibrous matrix, which sometimes
resembles phalanges. These variations are in the majority of cases
bilateral and symmetrical. The authors report the case of a 43-year-old
male patient who presented with an unusual unilateral complete ossification
of the stylohyoid apparatus, associated with vertebral and laryngeal
calcifications. Original latest generation CT scan and three-dimensional
MRI imagery are provided to illustrate this rare case.
BibTeX:
@article{Hardy2014,
  author = {Hardy, Hubert and Guichard, Benjamin and Eliezer, Mickael and Choussy, Olivier and Peron, Jean-Marc and Trost, Olivier},
  title = {Unilateral complete articulated ossification of the stylohyoid apparatus: case report and review of the literature.},
  month = {November},
  journal = {Surgical and radiologic anatomy : SRA},
  year = {2014},
  volume = {36},
  number = {9},
  pages = {941--945},
  doi = {10.1007/s00276-014-1328-0}
}

BibTeX:
@article{Lamy2014a,
  author = {Lamy, J. -B and Séroussi, B. and Griffon, N. and Kerdelhué, G. and Jaulent, M. -C and Bouaud, J.},
  title = {Toward a Formalization of the Process to Select {IMIA} Yearbook Best Papers},
  journal = {Methods of Information in Medicine},
  year = {2014},
  volume = {54},
  number = {2},
  pages = {135-144},
  url = {http://www.schattauer.de/en/magazine/subject-areas/journals-a-z/methods/contents/preprint-online/november-14-2014/issue/special/manuscript/23692/show.html},
  doi = {10.3414/ME14-01-0031}
}

BibTeX:
@inproceedings{Lecroq2014,
  author = {Lecroq, T. and Soualmia, L. F.},
  title = {Managing Large-Scale Genomic Datasets and Translation into Clinical Practice:},
  booktitle = {IMIA Yearbook},
  year = {2014},
  volume = {9},
  number = {1},
  pages = {212--214},
  url = {http://www.schattauer.de/index.php?id=1214&doi=10.15265/IY-2014-0039},
  doi = {10.15265/IY-2014-0039}
}

Abstract: Systemic sclerosis (SSc) has complex pathogenesis and likely multifactorial
causes. Environmental exposures have been suggested to play a role
in SSc pathogenesis, including occupational exposure to pollutants
and chemicals as well as use of drugs leading to modulation of immune
response. Thus, this case-control study aimed to assess: the relationship
between SSc and occupational exposure; and the risk of SSc related
to occupational exposure in male and female patients.From 2005 to
2008, 100 patients with a definite diagnosis of SSc were included
in the study; 3 age, gender, and smoking habits matched controls
were selected for each patient. A committee of experts evaluated
blindly occupational exposure to crystalline silica, white spirit,
organic solvents, ketones, welding fumes, epoxy resins, and pesticides;
an occupational exposure score was calculated for all subjects. Our
findings were compared with previous data in the literature.Increased
ORs for SSc were found for: crystalline silica (p<0.0001), white
spirit (p<0.0001), aromatic solvents (p=0.0002), chlorinated solvents
(p=0.014), trichlorethylene (p=0.044), ketones (p=0.002) and welding
fumes (p=0.021). Elevated risk associated with high final cumulative
score in SSc was observed for: crystalline silica, white spirit,
chlorinated solvents, trichlorethylene, aromatic solvents, any type
of solvents, ketones and welding fumes. A marked association between
SSc and occupational exposure was further found for: 1) crystalline
silica, chlorinated solvents, trichloroethylene, white spirit, ketones
and welding fumes in male patients; and 2) white spirit, aromatic
solvents, any type of solvent and ketones in female patients. Finally,
we did not find an association between SSc and: 1) the use of drugs
that have been speculated to play a role in SSc onset (anorexigens,
pentazocine, bromocriptine, l-tryptophan); 2) implants - that are
prosthesis, silicone implants, and contact lenses; and 3) dyeing
hair. In the literature, SSc has been associated with occupational
exposure to silica and solvents, while the association between SSc
and specific organic solvents and welding fumes has been anecdotally
reported.The following occupational factors have an impact in the
development of SSc: crystalline silica, white spirit, aromatic solvents,
chlorinated solvents, trichlorethylene, ketones and welding fumes.
The risk of SSc appears to be markedly associated with high cumulative
exposure. Finally, the association between SSc and occupational exposure
may be variable according to gender.
BibTeX:
@article{Marie2014,
  author = {Marie, I. and Gehanno, J-F. and Bubenheim, M. and Duval-Modeste, A-B. and Joly, P. and Dominique, S. and Bravard, P. and Noël, D. and Cailleux, A-F. and Weber, J. and Lagoutte, P. and Benichou, J. and Levesque, H.},
  title = {Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature.},
  month = {Feb},
  journal = {Autoimmun Rev},
  school = {Department of Internal Medicine, CHU Rouen, Rouen, France; INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France. Electronic address: isabelle.marie@chu-rouen.fr.},
  year = {2014},
  volume = {13},
  number = {2},
  pages = {151--156},
  url = {http://dx.doi.org/10.1016/j.autrev.2013.10.002},
  doi = {10.1016/j.autrev.2013.10.002}
}

Abstract: BACKGROUND: The frequency of antidepressant (ADs) prescription is
high, with general practitioners (GPs) responsible for about 80%
of the prescriptions. Some studies considered prescriptions meet
DSM criteria, while others stress inadequate use. The importance
of biological and psychosocial determinants of GP prescription behaviour
remains little explored. We aimed to describe the importance of these
biological and psychosocial determinants and their weight in the
daily practice of GPs'. METHODS: During a week chosen at random,
28 GPs collected the AD prescriptions made within the previous six
months, regardless of the reason for the patient contact. Bio psychosocial
and AD treatment characteristics were recorded for all patients.
In a random sample of 50 patients, patient characteristics were assessed
via a structured face-to-face interview with the GP. RESULTS: The
frequency of AD prescription was 8.90% [3.94 -17.02]. The GPs initiated
65.6% [60.1-70.8] of the prescriptions. The rate of AD prescription
for non-psychiatric conditions was 18%. Patients had from 1 to 9
conditions, showing a high level of multi-morbidity. There was a
strong influence of past medical history and contextual problems,
such as work related problems. CONCLUSION: AD prescription is related
to complex contextual situations and multi-morbid patients. GPs use
a bio psycho social approach, rather than a purely biological assessment.
Awareness of these influences could improve prescription by GPs.
BibTeX:
@article{Mercier2014,
  author = {Mercier, Alain and Auger-Aubin, Isabelle and Lebeau, Jean-Pierre and Schuers, Matthieu and Boulet, Pascal and Van Royen, Paul and Peremans, Lieve},
  title = {Why do general practitioners prescribe antidepressants to their patients? {A} pilot study.},
  journal = {BioPsychoSocial medicine},
  year = {2014},
  volume = {8},
  pages = {17},
  doi = {10.1186/1751-0759-8-17}
}

BibTeX:
@article{Morel2014,
  author = {Morel, F. and Peron, J.-M. and Trost, O.},
  title = {A plea for the systematic preservation of the deltopectoralis ({Bakamjian}) flap in pectoralis major flap harvesting.},
  month = {September},
  journal = {International journal of oral and maxillofacial surgery},
  year = {2014},
  volume = {43},
  number = {9},
  pages = {1169},
  doi = {10.1016/j.ijom.2014.05.012}
}

BibTeX:
@article{Trost2014,
  author = {Trost, Olivier and Peron, Jean-Marc},
  title = {Regarding unilateral nasomaxillary buttress fractures.},
  month = {November},
  journal = {Journal of plastic, reconstructive \& aesthetic surgery : JPRAS},
  year = {2014},
  volume = {67},
  number = {11},
  pages = {e278--279},
  doi = {10.1016/j.bjps.2014.07.012}
}

Abstract: RésuméObjectif Medline/PubMed est la base documentaire la plus
utilisée dans le domaine de la santé. L’objectif de ce travail était
de proposer une nouvelle méthode générique pour limiter une requête
quelconque effectuée en utilisant PubMed en utilisant le facteur
d’impact « relatif », en se limitant aux catégories A et B du score
SIGAPS, c’est-à-dire, aux « meilleurs articles » au sens du facteur
d’impact. Matériel et méthodes Nous avons utilisé le corpus complet
de PubMed comme référence, puis dix pathologies fréquentes en termes
d’indexation dans PubMed, et les citations de quatre prix Nobel.
Le facteur d’impact relatif (FIR) est calculé par discipline médicale
défini dans le Journal Citation Reports. Les deux requêtes incluant
les journaux de catégorie A (ou A ou B) ont pu être ajoutées à une
requête quelconque de PubMed, ce qui était un élément central en
termes de faisabilité. Résultats Le filtre par la catégorie A de
SIGAPS est plus large que celui des Core Clinical Journals (CCJ)
en sélectionnant 15,6 % du corpus de PubMed versus 8,6 % pour
le CCJ. Le temps de réponse sur l’ensemble du corpus de PubMed
est inférieur à deux secondes. Dans cinq pathologies sur dix, le
filtre FIR est plus efficace que le filtre CCJ. Pour les quatre
prix Nobel, le filtre FIR est beaucoup plus efficace que le filtre
FIR. Conclusion L’étude de faisabilité d’utiliser le facteur d’impact
relatif comme filtre d’une requête quelconque de Medline/PubMed
est positive. AbstractBackground Medline/PubMed is the most frequently
used medical bibliographic research database. The aim of this study
was to propose a new generic method to limit any Medline/PubMed
query based on the relative impact factor and the A &amp; B categories
of the SIGAPS score. Material and methods The entire PubMed corpus
was used for the feasibility study, then ten frequent diseases in
terms of PubMed indexing and the citations of four Nobel prize
winners. The relative impact factor (RIF) was calculated by medical
specialty defined in Journal Citation Reports. The two queries, which
included all the journals in category A (or A OR B), were added
to any Medline/PubMed query as a central point of the feasibility
study. Results Limitation using the SIGAPS category A was larger
than the when using the Core Clinical Journals (CCJ): 15.65% of
PubMed corpus vs 8.64% for CCJ. The response time of this limit
applied to the entire PubMed corpus was less than two seconds.
For five diseases out of ten, limiting the citations with the RIF
was more effective than with the CCJ. For the four Nobel prize
winners, limiting the citations with the RIF was more effective
than the CCJ. Conclusion The feasibility study to apply a new filter
based on the relative impact factor on any Medline/PubMed query
was positive.
BibTeX:
@article{Avillach2014,
  author = {Avillach, P. and Kerdelhué, G. and Devos, P. and Maisonneuve, H. and Darmoni, S. J.},
  title = {Limiter une requête Medline/{PubMed} aux articles publiés dans les revues les plus citées de chaque discipline},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2014},
  volume = {62},
  number = {6},
  pages = {361-365},
  url = {http://www.sciencedirect.com/science/article/pii/S0398762014007081},
  doi = {10.1016/j.respe.2014.09.008}
}

BibTeX:
@article{Chauvet2014,
  author = {Chauvet, C. and Jordan, P. and Bijaoui, A. and Delepine, A. and Fontaine, B. and Gehanno, J.F. and Hasni Pichard, H. and Haberer, M. and Bousquet, P.J. and Bessette, D.},
  title = {Diffusion numérique de l’information sur la prévention des cancers professionnels : exemple de l’élaboration d’un bulletin de veille (cancers pro actu) et d’une base de ressources (cancers pro doc) (institut national du cancer)},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2014},
  volume = {75},
  number = {3},
  pages = {S38--S38},
  doi = {10.1016/j.admp.2014.03.123}
}

Abstract: Nous proposons dans cet article une nouvelle approche d’indexation
de documents biomédicaux basée sur les réseaux possibilistes permettant
de les apparier partiellement aux termes du thésaurus MeSH (Medical
Subject Headings). La principale contribution de notre approche est
le traitement de l’imprécision et de l’incertitude liée à la tâche
d’indexation à travers l’utilisation de la théorie des possibilités.
En effet, nous proposons d’améliorer l’estimation de la pertinence
d’un document étant donné un concept en utilisant deux mesures :
la possibilité et la nécessité. La possibilité estime le degré de
rejet d’un document non pertinent étant donné un concept. La nécessité
de la pertinence d’un document évalue dans quelle mesure un document
est pertinent pour le concept. De plus, notre approche permet de
réduire les limites de l’appariement partiel qui génère de l’information
inutile, bien que ce type d’appariement permette de trouver dans
le document d’autres variantes du vocabulaire contrôlé. Pour ce faire,
nous proposons de filtrer l’index en utilisant les connaissances
fournies par l’UMLS (Unified Medical Langage System). Filtrer l’index
permet de ne garder que les concepts pertinents parmi ceux ayant
un sous-ensemble de leurs mots dans le document. Les expérimentations
réalisées sur les deux corpus OSHUMED et CISMeF ont montré des résultats
encourageants.
BibTeX:
@article{Chebil2014a,
  author = {Chebil, W and Soualmia, LF and Omri, M and Darmoni, SJ},
  title = {Extraction possibiliste de concepts MeSH à partir de documents biomédicaux},
  journal = {Revue d’Intelligence Artificielle},
  year = {2014},
  volume = {28},
  number = {6},
  pages = {729-752},
  url = {http://ria.revuesonline.com/article.jsp?articleId=20003},
  doi = {10.3166/ria.28.729-752}
}

BibTeX:
@article{Darmoni2014,
  author = {Darmoni, Stefan and Griffon, Nicolas and Massari, Philippe},
  title = {Les systèmes d'aide à la décision médicale},
  month = {November},
  journal = {Annales des Mines - Réalités industrielles},
  year = {2014},
  volume = {2014},
  number = {4},
  pages = {47--50},
  url = {http://www.cairn.info/article.php?ID_ARTICLE=RINDU_144_0047},
  doi = {10.3917/rindu.144.0047}
}

Abstract: Buts de l’étude Le lambeau antébrachial radial composite est une option
thérapeutique pour les grandes pertes de substances traumatiques
ou cancérologiques de la face. Or ce lambeau a souvent été critiqué
pour sa réserve osseuse jugée inadéquate et insuffisante pour reconstruire
des pertes de substances osseuses, ou pour la réhabilitation prothétique
implanto-portée. En outre, une morbidité élevée du site donneur est
souvent déplorée. Le but de ce travail anatomoradiologique était
d’étudier la vascularisation du lambeau antébrachial radial composite,
et en particulier de sa baguette osseuse. Matériel et méthodes Une
étude anatomoradiologique a été réalisée sur sept avant-bras prélevés
sur des cadavres frais. Après lavage des vaisseaux par injection
intra-artérielle d’un mélange d’eau et d’acétate de potassium, une
préparation par injection intra-artérielle d’un mélange d’oxyde de
plomb rouge et de gélatine était pratiquée. Après recongélation,
une étude tomodensitométrique des pièces anatomiques ainsi préparées
était réalisée. Dans un second temps, les lambeaux antébrachiaux
composites étaient prélevés, puis analysés par examen microscannographique
(NanoSPECT-CT Bioscan ® , voxel 220 microns). Les branches collatérales
cutanées et osseuses issues de l’artère radiale étaient comptées
et localisées en trois tiers (supérieur, moyen et inférieur). Résultats
Une artère nourricière diaphysaire principale radiale était mise
en évidence dans les sept dissections : le foramen nourricier se
situait à la face antéromédiale du radius, entre 45 et 65 % de sa
longueur. Un système vasculaire périosté dense était mis en évidence,
alimenté par une à quatre branches musculopériostées et une à six
artères fascio-périostées. L’étude des lambeaux a au total mis en
évidence en moyenne cinq branches radiales à destinée osseuse et
12 branches perforantes pour la palette cutanée. Conclusion Les résultats
de cette étude préclinique suggéraient qu’il était possible de prélever
avec une grande sécurité vasculaire une baguette osseuse radiale
allant jusqu’à 16 cm, sans tenir compte de la morbidité du site donneur
qui reste une limite majeure de ce lambeau. L’approche anatomoradiologique
(tomodensitométrie conventionnelle et microscanner) permettait une
étude fine de la microvascularisation tissulaire, aisément applicable
aux lambeaux, et ouvrant un champ de recherches original dans le
domaine de la chirurgie réparatrice.
BibTeX:
@article{DeTaddeo2014,
  author = {De Taddéo, A. and Collin, B. and Hardy, H. and Guichard, B. and Trouilloud, P. and Trost, O.},
  title = {Peut-on prélever une grande baguette osseuse radiale dans le lambeau antébrachial radial composite ? Étude radio-anatomique et microscannographique originale},
  journal = {Annales de chirurgie plastique et esthétique},
  year = {2014},
  volume = {59},
  number = {3},
  pages = {170--176},
  doi = {10.1016/j.anplas.2013.12.005}
}

Abstract: L’objectif attribué par la loi aux services de santé au travail est
d’éviter toute altération de la santé des travailleurs du fait de
leur travail mais également de contribuer au maintien dans l’emploi
des travailleurs. À cette fin, les services de santé au travail conduisent,
entre autres, des actions de surveillance systématique de la santé,
dans une optique de dépistage pour des pathologies en lien avec le
travail ou pouvant avoir un retentissement sur le travail. Nous laisserons
de coté la surveillance médicale renforcée, qui fait l’objet de recommandations
spécifiques. Dans le cadre d’un suivi de santé non motivé par une
exposition à des facteurs de risques professionnels, la question
posée est celle de l’intérêt d’un examen clinique régulier, assorti
ou non d’examens para-cliniques. Si la littérature est limitée dans
le domaine de la santé au travail, elle est abondante dans le champ
de la santé publique et permet d’affirmer que ce type de suivi systématique
n’apporte pas de bénéfice mesurable en terme de limitation de la
mortalité ou de la morbidité, globale, cardiovasculaire ou par cancer
[1] . Il n’est de plus pas dénué d’effets secondaires, auxquels il
faut ajouter le risque d’exclusion propre à la santé au travail.
Il convient toutefois souligner que l’intérêt de ce type de rendez-vous
de santé régulier n’a pas été évalué en terme de maintien de la relation
ou de la confiance, entre le patient/salarié et le médecin. L’intérêt
d’un dépistage étant lié à la fréquence de la maladie dans la population
qui bénéficie du dépistage, il peut être plus important dans certains
groupes exposés à des nuisances professionnelles. On peut ainsi citer
deux exemples ayant fait l’objet de recommandations récentes de la
part de la Société française de médecine du travail. Chez les sujets
exposés à des allergènes, il est recommandé de procéder au dépistage
de la rhinite professionnelle en particulier pendant l’apprentissage
ou les deux premières années d’exposition [2] Chez les travailleurs
postés et/ou de nuit, il est recommandé de dépister une privation
chronique de sommeil et des épisodes de somnolence ainsi que de mesurer
le poids et la tension de façon annuelle [3] Il est intéressant de
noter que ces dépistages reposent principalement sur l’interrogatoire,
et peuvent donc impliquer l’infirmier de santé au travail. Le rendez
vous de santé servant de support au dépistage peut également être
l’occasion d’une information sur les risques professionnels, comme
cela a été proposé récemment chez les salariés exposés à de la manutention
manuelle de charges [4] Enfin, la notion de dépistage peut également
être élargie aux conditions de travail et aux expositions professionnelles.
Cela peut être r...
BibTeX:
@article{Gehanno2014a,
  author = {Gehanno, J.-F. and Teissier, P. and Soulat, J.-M.},
  title = {État des connaissances sur les dépistages en santé au travail},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2014},
  volume = {75},
  number = {5},
  pages = {513--514},
  doi = {10.1016/j.admp.2014.07.010}
}

Abstract: Introduction et but de l’étude Le travail posté et particulièrement
le travail de nuit engendre des perturbations au niveau des rythmes
biologiques des salariés exposés pouvant être à l’origine de troubles
du sommeil, de troubles digestifs et de troubles nutritionnels, notamment
avec l’apparition d’un surpoids. L’objectif de cette étude était
double : Evaluer la prévalence des troubles nutritionnels au sein
du personnel de nuit du CHU de Rouen (notamment la surcharge pondérale
et les TCA) et repérer les facteurs associés à la présence d’un TCA
chez les travailleurs de nuit afin de mettre en place une prise en
charge spécifique et adaptée au sein du CHU de Rouen. Matériel et
méthodes Un questionnaire anonyme a été distribué à l’ensemble des
agents travaillant de nuit au sein du CHU de Rouen. Plusieurs critères
ont été pris en compte : des critères socio-démographiques (age,
sexe, fonction) des critères nutritionnels (pratique d’une activité
physique, indice de masse corporelle (IMC), existence de grignotage,
d’hyperphagie, antécédents de régime, prise de poids depuis le début
du travail de nuit, et dépistage des TCA (questionnaire SCOFF)),
des critères concernant le statut tabagique et le sommeil (Echelle
EPWORTH). Résultats et Analyse statistique Au total, 325 agents de
nuit ont répondu au questionnaire soit un taux de réponse de 47 %.
Plus de 9 agents sur 10 (91,5 étaient de sexe féminin et près
de la moitié des agents était des infirmières (49 . Nos résultats
retrouvent une prévalence de la surcharge pondérale de 33,3 % (n
= 115) et une prévalence des TCA (SCOFF positif) de 15,5 % (n =
54). Un agent sur cinq (20,6 n = 72) présentait un score d’EPWORTH
évoca-teur de syndrome des apnées du sommeil. Après analyse par régression
logistique multivariée, les facteurs associées significativement
à un risque de TCA étaient d’avoir un score d’EPWORTH élevé (ORa
= 2,13), avoir eu recours à des régimes amaigrissants (ORa = 2,51),
ne pas pratiquer d’activité physique (OR a = 3,61), et avoir pris
du poids depuis le début du travail de nuit (ORa = 1,25). Prés des
trois-quarts des agents ayant un problème de poids ou un risque de
TCA ont exprimé un intérêt pour la mise en place d’une aide diététique.
Conclusion Ce travail retrouve une prévalence du surpoids comparable
aux données de la littérature. La prévalence des personnes à risque
de TCA a été étudié pour la première fois et s’élève à plus de 15
%. Ce risque est particulièrement augmenté en cas de sédentarité,
de prise de poids depuis le travail de nuit, d’antécédents de régime
et de risque de syndrome des apnées du sommeil. Sur les bases de
ce travail, la mise en place d’une consultation diététique spécialisée
pour les agents de nuit paraît opportune et est en cours d’expérimentation.
BibTeX:
@article{Grigioni2014,
  author = {Grigioni, S. and Pascal, E. and Horlaville, M. and Dechelotte, P. and Gehanno, J.F. and Folope, V.},
  title = {P043: {Prévalence} de la surcharge pondérale et des troubles du comportement alimentaire ({TCA}) chez les soignants travaillant de nuit : Étude chez 325 agents du {CHU} de {Rouen}},
  journal = {Nutrition clinique et métabolisme},
  year = {2014},
  volume = {28},
  pages = {S90--S90},
  doi = {10.1016/S0985-0562(14)70686-7}
}

Abstract: Contexte. La filière universitaire de médecine générale (FUMG) est
née en 2004 avec la création du diplôme d’études spécialisées (DES)
de médecine générale (MG). Les premiers chefs de clinique des universités
(CCU) ont été nommés en 2007. Cette étude a eu pour objectif de décrire
leur statut, leur devenir et leurs perspectives de carrière.Méthode.
Suivi longitudinal de la cohorte des CCU, complété par un questionnaire
envoyé en novembre 2013.Résultats. Sur les 126 CCU de MG nommés depuis
2007, 80 étaient en poste lors de l’étude (chiffre en stagnation
depuis 2010). Quarante-six avaient fini leur clinicat : 4 (9
avaient été nommés maîtres de conférences des universités (MCU),
8 (17 , maîtres de conférences associés (MCA), 10 (22 chefs
de clinique associés (CCA), 13 (27 étaient chargés d’enseignement
(CE) ou maîtres de stage des universités (MSU), et 11 (24 avaient
quitté la FUMG. 109 CCU (87 ont répondu au questionnaire. Parmi
les 68 CCU répondants en poste lors de l’étude, 33 (48 envisageaient
de passer le concours de MCU, 14 (20 de devenir MCA et 18 (26
de faire de la recherche ou de l’enseignement. Parmi les 41 anciens
CCU répondants, 21 (51 avaient accès à un poste d’enseignant-chercheur
de type CCA, MCA ou MCU. Vingt n’ont pas eu accès à ce type de poste.
Parmi eux, 12 ont invoqué des freins divers : manque de soutien de
leur département de médecine générale (DMG), charge de travail nécessaire,
manque de lisibilité sur l’avenir, épuisement professionnel.Discussion.
Les CCU de MG représentent 5 % de l’ensemble des CCU alors qu’ils
participent à l’encadrement pédagogique de 50 % des internes de
médecine en France. La structuration de la FUMG se fera avec une
volonté politique forte et une dynamique soutenue des DMG.
BibTeX:
@article{Laporte2014,
  author = {Laporte, C. and Darmon, D and Gelly, J. and Bonnet, P. and Bouchez, T and Schuers, M.},
  title = {Chefs de clinique des universités : que sont-ils devenus ?},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2014},
  number = {116},
  pages = {275--9}
}

Abstract: Contexte. En France, peu de données permettent d’avoir une vue d’ensemble
des motifs de recours aux soins et des problèmes de santé en soins
primaires. Les données des quelques opérateurs privés existants sont
peu accessibles.Objectif. Décrire le protocole et les principaux
résultats de l’étude ECOGEN en termes de distribution des motifs
et des résultats de consultation.Méthodes. Étude transversale nationale
multicentrique réalisée en patientèle de médecine générale. Les investigateurs
étaient 54 internes de 27 facultés de médecine, en stage supervisé
de niveau 1 chez 128 maîtres de stage universitaires. Ils ont été
formés à la structuration du dossier médical informatisé et à l’utilisation
de la Classification internationale des soins primaires (CISP-2).
Ils ont recueilli et saisi des variables spécifiques à chaque consultation
sur une période de 20 jours répartis entre décembre 2011 et avril
2012, ainsi que des variables relatives à leur(s) maître(s) de stage.Résultats.
Les données de consultation ont été enregistrées pour 20 613 consultations.
Chaque consultation comportait en moyenne 2,6 motifs de consultation,
2,2 résultats de consultation, et 4,7 procédures de soins. Chaque
résultat de consultation était ainsi associé à 1,2 motif de consultation
et à 2,1 procédures de soins. Le résultat de consultation le plus
fréquent correspondait à des situations de prévention (11 % des
résultats de consultation), suivi des facteurs de risque cardiovasculaires
: hypertension artérielle non compliquée (7 , dyslipidémie (3,7
, diabète (2,4 . Le motif de consultation le plus fréquent
était la demande de renouvellement de traitement médicamenteux (21,3
, devant le suivi d’un problème de santé (5,7 et la discussion
de résultats d’examens (4 .Conclusion. L’étude ECOGEN atteste
de la diversité et de la continuité des soins du médecin généraliste.
Celui-ci est le véritable partenaire de ses patients, au service
de la préservation et l’amélioration de leur santé.
BibTeX:
@article{Letrilliart2014,
  author = {Letrilliart, L. and Supper, I and Schuers, M. and Darmon, D and Boulet, P and Favre, M and Guerin, MH and Mercier, A.},
  title = {{ECOGEN} : étude des Éléments de la {COnsultation} en médecine {GENérale}},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2014},
  number = {114},
  pages = {148--57}
}

BibTeX:
@article{Marie2014b,
  author = {Marie, I. and Duval-Modeste, A.-B. and Joly, P. and Menard, J.-F. and Dominique, S. and Bravard, P. and Noël, D. and Gehanno, J.-F. and Benichou, J. and Levesque, H.},
  title = {Influence des facteurs professionnels sur les caractéristiques de la sclérodermie systémique},
  journal = {La Revue de médecine interne},
  year = {2014},
  volume = {35},
  pages = {A72--A72},
  doi = {10.1016/j.revmed.2014.03.089}
}

BibTeX:
@article{Pegot2014,
  author = {Pégot, A. and Pinson, C. and Guichard, B. and Hardy, H. and Péron, J.-M. and Trost, O.},
  title = {Fenestration de la veine jugulaire interne gauche : à propos d’un cas atypique},
  journal = {Morphologie : bulletin de l'Association des anatomistes},
  year = {2014},
  volume = {98},
  number = {322},
  pages = {113--113},
  doi = {10.1016/j.morpho.2014.04.039}
}

BibTeX:
@article{Trost2014b,
  author = {Trost, Olivier},
  title = {Un histoséminaire de pathologie buccale et stomatologique pour éviter au pathologiste de tomber sur une dent},
  journal = {Annales de pathologie},
  year = {2014},
  volume = {34},
  number = {3},
  pages = {169--170},
  doi = {10.1016/j.annpat.2014.04.012}
}

Abstract: La désignation des structures anatomiques exige une rigueur absolue,
aussi bien en pratique clinique quotidienne qu’en recherche et en
enseignement. La nomenclature anatomique internationale utilise le
latin. En France, une nomenclature anatomique francisée peine à être
adoptée en pratique clinique. Les principes de cette nomenclature
sont la suppression systématique des noms propres, le respect des
définitions de l’anatomie générale et la francisation des termes
latins. Malgré une grande rigueur, quelques termes restent inappropriés,
car ils induisent des confusions ou des imprécisions. De plus, ce
langage d’utilisation internationale est moins aisé à manier au quotidien
par les cliniciens. Le but de cet article était de rappeler le vocabulaire
anatomique utile en chirurgie orale et maxillo-faciale, et de justifier
son emploi en clinique, en recherche et en pédagogie.
BibTeX:
@article{Trost2014a,
  author = {Trost, O. and Hardy, H. and Péron, J.-M. and Trouilloud, P.},
  title = {Nomenclature anatomique utile en chirurgie orale et maxillo-faciale},
  journal = {Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale},
  year = {2014},
  volume = {115},
  number = {5},
  pages = {287--292},
  doi = {10.1016/j.revsto.2014.09.002}
}

Abstract: Les mélanomes mandibulaires, primitifs ou métastatiques, sont extrêmement
rares. Nous rapportons le cas original d’une femme de 55 ans traitée
16 ans auparavant d’un mélanome cutané, et présentant un volumineux
mélanome achromique mandibulaire : métastase très tardive et de nature
histologique différente du mélanome cutané, ou mélanome muqueux achromique
primitif métachrone ?
BibTeX:
@article{Vierne2014,
  author = {Vierne, C. and Hardy, H. and Guichard, B. and Barat, M. and Péron, J-M and Trost, O.},
  title = {Métastase mandibulaire d’un mélanome cutané ou mélanome achromique primitif métachrone de la cavité orale ? À propos d’un cas et revue de la littérature},
  journal = {Annales de chirurgie plastique et esthétique},
  year = {2014},
  volume = {59},
  number = {4},
  pages = {276--9},
  doi = {10.1016/j.anplas.2014.01.002}
}

BibTeX:
@inproceedings{Cabot2014,
  author = {Cabot, C and Grosjean, J and Lelong, R and Lefebvre, A and Lecroq, T and Soualmia, LF and Darmoni, SJ},
  title = {Omic Data Modelling for Information Retrieval},
  booktitle = {Proceedings of the 2nd International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO},
  year = {2014},
  url = {http://iwbbio.ugr.es/2014/papers/IWBBIO_2014_paper_50.pdf}
}

BibTeX:
@inproceedings{Chniti2014a,
  author = {Chniti, Amina and Traore, Lamine and Hussain, Sajjad and Griffon, Nicolas and Darmoni, Stefan and Charlet, Jean and Sadou, Eric and Ouagne, David and Lepage, Eric and Daniel, Christel},
  title = {A Semantic Interoperability Framework for Facilitating Cross-Hospital Exchanges.},
  journal = {Stud Health Technol Inform},
  school = {AP-HP, F-75006, Paris, France.},
  year = {2014},
  volume = {205},
  pages = {1255}
}

BibTeX:
@inproceedings{Dhondt2014,
  author = {D'hondt, E and Grau, B and Darmoni, S and Névéol, A and Schuers, M and Zweigenbaum, P},
  title = {LIMSI @ 2014 Clinical Decision Support Track},
  booktitle = {TREC Working Notes},
  year = {2014},
  url = {https://perso.limsi.fr/neveol/DhondtTREC2014WorkingNotes.pdf}
}

BibTeX:
@inproceedings{Gicquel2014,
  author = {Gicquel, Q and Kergoulay, I and Gerbier-Colomban, S and Chariout, S and Bittar, A and Segond, F and Darmoni, SJ and Metzger, MH},
  title = {Annotation methods to develop and evaluate an expert system based on natural language processing in electronic medical records},
  booktitle = {MIE},
  year = {2014},
  url = {http://person.hst.aau.dk/ska/MIE2014/Slides/S12/ID074.pdf}
}

BibTeX:
@inproceedings{Griffon2014b,
  author = {Griffon, N and Merabti, T and Cormont, S and Tariel-Laurent, S and Massari, P and Lepage, E and Chniti, A and Daniel, C and Darmoni, SJ},
  title = {Preservation of Information in Terminology Transcoding},
  booktitle = {Stud Health Technol Inform MIE},
  year = {2014},
  volume = {205},
  pages = {156-160},
  doi = {10.3233/978-1-61499-432-9-156}
}

Abstract: The volume of data in the biomedical field constantly grows. The vast
majority of information retrieval systems are based on controlled
vocabularies and most specifically on terminologies or ontologies
(T/O). These classification structures allow indexing, coding, annotating
various types of documents. In Health, many T/O have been created
for different purposes and it became a problem to find specific concepts
in the multitude of nomenclatures. The NCBO (National Center for
Biomedical Ontologies, Stanford University) BioPortal project and
the CISMeF (Catalogue et Index des Sites M'edicaux de langue Franc¸aise,
Rouen University Hospital) HeTOP portals have been developed to tackle
this issue. While both portals are designed to store and make T/O
available to the community, they are also very different mainly because
of their basic purposes. The present work consists in comparing both
portals and in answering the following question: is it possible to
merge BioPortal and HeTOP into one unique solution to manage T/O
?
BibTeX:
@inproceedings{Grosjean2014,
  author = {Grosjean, J and Soualmia, LF and Bouarech, K and Jonquet, C and Darmoni, SJ},
  title = {Comparing BioPortal and HeTOP: towards a unique biomedical ontology portal ?},
  booktitle = {IWBBIO'14: 2nd International Work-Conference on Bioinformatics and Biomedical Engineering},
  address = {Granada, Spain},
  year = {2014},
  pages = {227–237},
  url = {http://iwbbio.ugr.es/2014/papers/IWBBIO_2014_paper_27.pdf}
}

Abstract: Background: main biomedical information retrieval systems are based
on controlled vocabularies and most specifically on terminologies
or ontologies (T/O). These classification structures allow indexing,
coding, annotating different kind of documents. Many T/O have been
created for different purposes and it became a problem for finding
specific concepts in the multitude of existing nomenclatures. The
NCBO (National Center for Biomedical Ontologies) BioPortal and the
CISMeF (Catalogue et Index des Sites Médicaux de langue Française)
HeTOP projects have been developed to tackle this issue. Objective:
the present work consists in comparing both portals. Methods: we
hereby are proposing a set of criteria to compare bio-ontologies
portals in terms of goals, features, technologies and usability.
Results: BioPortal and HeTOP have been compared based on the given
criteria. While both portals are designed to store and make T/O available
to the community and are sharing many basic features, they differ
on several points mainly because of their basic purposes. Conclusion:
thanks to the comparison criteria, we can assume that a merge between
BioPortal and HeTOP is possible in terms of functionalities. The
main difficulties will be about merging the data repositories and
applying different policies on T/O content.
BibTeX:
@inproceedings{Grosjean2014a,
  author = {Grosjean, Julien and Soualmia, Lina F. and Bouarech, Khedidja and Jonquet, Clément and Darmoni, Stéfan J.},
  title = {An Approach to Compare Bio-Ontologies Portals.},
  journal = {Stud Health Technol Inform},
  school = {TIBS, LITIS EA4108, Rouen University Hospital, France.},
  year = {2014},
  volume = {205},
  pages = {1008--1012}
}

Abstract: In order to identify variations between two or several versions of
Clinical Practice Guidelines, we propose a method based on the detection
of noun phrases. Currently, we are developing a comparison approach
to extract similar and different elements between medical documents
in French in order to identify any significant changes such as new
medical terms or concepts, new treatments etc. In this paper, we
describe a basic initial step for this comparison approach i.e. detecting
noun phrases. This step is based on patterns constructed from six
main medical terminologies used in document indexing. The patterns
are constructed by using a Tree Tagger. To avoid a great number of
generated patterns, the most relevant ones are selected that are
able identify more than 80% of the six terminologies used in this
study. These steps allowed us to obtain a manageable list of 262
patterns which have been evaluated. Using this list of patterns,
708 maximal noun phrases were found, with, 364 correct phrases which
represent a 51.41% precision. However by detecting these phrases
manually, 602 maximal noun phrases were found which represent a 60.47%
recall and therefore a 55.57% F-measure. We attempted to improve
these results by increasing the number of patterns from 262 to 493.
A total of 729 maximal noun phrases were obtained, with 365 which
were correct, and corresponded to a 50.07% precision, 60.63% recall
and 54.85% F-measure.
BibTeX:
@incollection{Merabti2014,
  author = {Merabti, A and Soualmia, LF. and Darmoni, SJ},
  title = {Detecting Noun Phrases in Biomedical Terminologies: The First Step in Managing the Evolution of Knowledge},
  booktitle = {Health Information Science},
  month = {January},
  publisher = {Springer International Publishing},
  year = {2014},
  series = {Lecture Notes in Computer Science},
  number = {8423},
  pages = {109--120},
  doi = {10.1007/978-3-319-06269-3_12}
}

BibTeX:
@inproceedings{NEVEOL14.604,
  author = {Névéol, A and Grosjean, J and Darmoni, SJ and Zweigenbaum, P},
  title = {Language Resources for French in the Biomedical Domain},
  booktitle = {Proceedings of the Ninth International Conference on Language Resources and Evaluation (LREC'14)},
  address = {Reykjavik, Iceland},
  month = {may},
  publisher = {European Language Resources Association (ELRA)},
  year = {2014},
  url = {http://www.lrec-conf.org/proceedings/lrec2014/pdf/604_Paper.pdf}
}

BibTeX:
@inproceedings{Chniti2014,
  author = {Chniti, A and Griffon, N and Traore, L and Hussain, S and Daniel, C},
  title = {Terminologies et référentiels d’interopérabilité sémantique en Santé},
  booktitle = {JFIM},
  year = {2014},
  url = {http://ceur-ws.org/Vol-1379/paper-05.pdf}
}

BibTeX:
@inproceedings{Joulakian2014,
  author = {Joulakian, M and Griffon, N and Schuers, M and Lepage, E and Savoye-Collet, C and Skalli, S and Massari, P and Darmoni, SJ},
  title = {Indicateurs en biologie et en imagerie au sein des systèmes d’information de santé},
  booktitle = {JFIM},
  year = {2014}
}

BibTeX:
@inproceedings{Lamy2014,
  author = {Lamy, JB and Soualmia, LF and Venot, A and Duc},
  title = {Validation de la sémantique d'un langage iconique médical à l'aide d'une ontologie : méthodes et applications},
  booktitle = {Actes des 25° journées francophones d'Ingénierie des Connaissances, IC'14},
  address = {Clermont-Ferrand, France},
  month = {May},
  year = {2014},
  pages = {51-62},
  url = {https://hal.archives-ouvertes.fr/hal-01004802/document}
}

BibTeX:
@inproceedings{Lelong2014,
  author = {Lelong, R and Merabti, T and Grosjean, J and Joulakian, M and Griffon, N and Dahamna, B and Cuggia, M and Pereira, S and Grabar, N and Thiessard, F and Massari, P and Darmoni, SJ},
  title = {Moteur de recherche sémantique au sein du dossier du patient informatisé : langage de requêtes spécifique},
  booktitle = {JFIM},
  year = {2014}
}

BibTeX:
@inproceedings{Metzger2014,
  author = {Metzger, M and Giquel, Q and Rabarijaona, D and Segond, F and Bittar, A and Dini, L and Soualmia, LF and Darmoni, SJ},
  title = {Usage secondaire du dossier médical informatisé à des fins épidémiologiques et d’évaluation de la qualité des soins : le projet SYNODOS},
  booktitle = {Actes des Journées Francophones d’Informatique Médicale (JFIM), Pré-symposium French Special Interest Groupe of International Medical Informatics, (FR SIG IMIA)},
  address = {Fès},
  year = {2014},
  volume = {1379},
  pages = {152–161}
}

Abstract: Le Dossier Patient Informatisé (DPI) constitue une source d’information
pour des applications aussi variées que la recherche médicale, l’aide
à la décision, la médecine factuelle ou la surveillance épidémiologique.
Les publications utilisant l’analyse textuelle pour traiter du dossier
patient sont en progression constante. Bien que donnant de très bons
résultats, une telle approche fait apparaitre un certain nombre de
défis, tels que la nécessité d’intégrer connaissances linguistiques
et connaissances métier. Se basant sur une expérience précédente,
cet article montre comment lier l’analyse linguistique, la représentation
des connaissances, les ontologies médicales et le raisonnement afin
de fournir un système générique permettant d’extraire, de structurer
et d’exploiter l’information provenant des DPIs.
BibTeX:
@inproceedings{Segond2014,
  author = {Segond, F and Ponomareva, A and Rabarijaona, D and Bittar, A and Kergourlay, I and Darmoni, SJ and Gicquel, Q and Metzher, MH},
  title = {Bien représenter pour mieux raisonner : deux approches pour le dossier patient},
  booktitle = {Atelier IC et Santé},
  address = {Clermont Ferrand},
  month = {Mai},
  year = {2014}
}

BibTeX:
@inproceedings{cabot2014b,
  author = {C. Cabot and J. Grosjean and R. Lelong and A. Lefebvre and T. Lecroq and L. F. Soualmia and S. J. Darmoni},
  title = {Integrating omic and clinical data in electronic health records for visualisation and retrieval},
  booktitle = {3ème Journ\'ee Scientifique de l'IRIB},
  address = {Caug\'e, France},
  year = {2014},
  pages = {64}
}

BibTeX:
@inproceedings{Cabot2014a,
  author = {Chloé Cabot and Mélissa Mary and Chadi Saad and Alexandre Renaux and Alexis Bertrand and Amandine Velt and Arnaud Lefebvre and Caroline Bérard and Nicolas Vergne and Hélène Dauchel},
  title = {GC- VC/DGE: a user-friendly web application for Going over Concordance across results from NGS bioinformatics analytic pipelines},
  booktitle = {ECCB 2014},
  address = {Strasbourg, France},
  year = {2014}
}

BibTeX:
@inproceedings{Cabot2014b,
  author = {Chloé Cabot and Mélissa Mary and Chadi Saad and Alexandre Renaux and Alexis Bertrand and Amandine Velt and Arnaud Lefebvre and Caroline Bérard and Nicolas Vergne and Hélène Dauchel},
  title = {GC- VC/DGE: a user-friendly web application for Going over Concordance across results from NGS bioinformatics analytic pipelines},
  booktitle = {3ème Journ\'ee Scientifique de l'IRIB},
  address = {Caug\'e, France},
  year = {2014}
}

BibTeX:
@inproceedings{Kerdelhue2014,
  author = {Kerdelhué, G and Grosjean, J and Darmoni, SJ},
  title = {A PubMed third party for French Language (and possibly others)},
  booktitle = {14th EAHIL Conference},
  year = {2014}
}

BibTeX:
@inproceedings{Lefebvre2014b,
  author = {Arnaud Lefebvre and Alexandra Martins and Karim Labrèche and Vivien Deshaies and Alan Lahure and Pascaline Gaildrat and Hélène Dauchel and C. Cabot and J. Grosjean and R. Lelong and A. Lefebvre and T. Lecroq and L. F. Soualmia and S. J. Darmoni},
  title = {HExoSplice: a bioinformatics software based on overlapping hexamer scores for prediction and stratification of exonic variants altering splicing regulation of human genes},
  booktitle = {3ème Journ\'ee Scientifique de l'IRIB},
  address = {Caug\'e, France},
  year = {2014}
}

BibTeX:
@inproceedings{Mary2014,
  author = {Mary, M and Gansel, X and Soualmia, LF},
  title = {LOINC \& SNOMED-CT: usability and challenges to code identification tests and results for automated in vitro diagnostics systems.},
  booktitle = {13th European Conference on Computational Biology},
  address = {Strasbourg, France},
  month = {September},
  year = {2014}
}

BibTeX:
@inproceedings{Neveol2014,
  author = {Névéol, A and Déleger, L and Burgun, A and D'hondt, E and Griffon, N and Grouin, C and Hamon, T and Lavergne, T and Ligozat, AL and Pham, AD and rabary, C and Tannier, X and Tapi-Nzal, MD and Zweigenbaum, P},
  title = {CABeRneT: Compréhension Automatique de Textes Biomédicaux pour la Recherche Translationnelle},
  booktitle = {forum Digiteo STIC du Campus},
  month = {Décembre},
  year = {2014}
}

Abstract: This chapter explains why it is hard to use medical language in computer
applications and why the computer must adopt the human interpretation
of medical words to avoid misunderstandings linked to ambiguity,
homonymy and synonymy. Terminological resources are specific representations
of medical language for dedicated use in particular health domains.
We describe here the components of terminology (terms, concepts,
relationships between concepts, definitions, constraints). The various
artefacts of terminological resources (e.g. thesaurus, classification,
nomenclature) are defined. We also provide examples of the dedicated
use of terminological resources, such as disease coding, the indexing
of biomedical publications, reasoning in decision support systems
and data entry into electronic medical records. ICD 10, SNOMED
CT, and MeSH are among the terminologies used in the examples.
Alignment methods are described, making it possible to identify equivalent
terms in different terminologies and to bridge different domains
in health. We also present plans for multi-terminological servers,
such as the UMLS (Unified Medical Language Systems), which provide
a key vocabulary linking heterogeneous health terminologies in different
languages.
BibTeX:
@incollection{Duclos2014,
  author = {Duclos, C. and Burgun, A. and Lamy, J. B. and Landais, P. and Rodrigues, J. M. and Soualmia, L. and Zweigenbaum, P.},
  title = {Medical Vocabulary, Terminological Resources and Information Coding in the Health Domain},
  booktitle = {Medical Informatics, e-Health},
  month = {January},
  publisher = {Springer Paris},
  year = {2014},
  series = {Health Informatics},
  pages = {11--41},
  url = {http://link.springer.com/chapter/10.1007/978-2-8178-0478-1_2},
  doi = {10.1007/978-2-8178-0478-1_2}
}

Abstract: This chapter describes the various types of document available via
the Internet for the dissemination of health knowledge. It describes
the process for the publication of scientific articles reporting
the results of research. The concepts of journal impact factor, citation
base and h-index are explained. The Cochrane collaboration for literature
reviews and meta-analysis is described. The goals of national and
international clinical guidelines are explained and examples are
provided of websites providing access to such guidelines. The various
types of training materials available from e-learning platforms for
medical students are described. This chapter also takes into account
drug monographs, which are particularly useful for prescription and
disease knowledge bases. Examples of resources useful to members
of the public are also provided and we describe the methods for accessing
health knowledge, including details of the resource indexing process
and the MeSH thesaurus frequently used for indexing. The quality
of health information on the Internet is also considered and the
principal quality criteria are listed. The HON foundation and certification
are described.
BibTeX:
@incollection{Venot2014,
  author = {Venot, A. and Charlet, J. and Darmoni, S. and Duclos, C. and Dufour, J. C. and Soualmia, L.},
  title = {Management and Dissemination of Health Knowledge},
  booktitle = {Medical Informatics, e-Health},
  month = {January},
  publisher = {Springer Paris},
  year = {2014},
  series = {Health Informatics},
  pages = {43--64},
  url = {http://link.springer.com/chapter/10.1007/978-2-8178-0478-1_3},
  doi = {10.1007/978-2-8178-0478-1_3}
}

BibTeX:
@article{Neveol2014a,
  author = {Névéol, A and Darmoni, SJ and Zweigenbaum, P},
  title = {Les ressources pour le traitement automatique de la langue biomédicale en français: appel à la communauté},
  journal = {Newsletter de l'Association Française d'Informatique Médicale},
  year = {2014},
  url = {http://france-aim.org/aim/sites/default/files/News4_0.pdf}
}

BibTeX:
@phdthesis{Grosjean2014b,
  author = {Julien Grosjean},
  title = {Modélisation, réalisation et évaluation d’un portail Multi-terminologique, Multi-discipline, Multi-lingue (3M) dans le cadre de la Plateforme d’Indexation Régionale (PlaIR)},
  school = {Université de Rouen, École doctorale Sciences Physiques, Mathématiques et de l'Information pour l'Ingénieur},
  year = {2014},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2017/01/thèse_Julien_Grosjean_final.pdf}
}

2013


Abstract: OBJECTIVES: Self-efficacy is defined as a person's beliefs in his
or her abilities to successfully complete a task, and has been shown
to influence student motivation and academic achievement. The purpose
of this study was to evaluate the impact of a new European teaching
module in occupational medicine on undergraduate students' self-efficacy
and knowledge in the subject matter. METHODS: Pre-, in-between, and
posttraining tests were used to assess self-efficacy and knowledge
building of 261 third-year medical students on occupational health
issues. Determinants of self-efficacy and knowledge were also identified.
Repeated measurement data were analyzed with multilevel statistical
procedures. RESULTS: The level of self-efficacy and knowledge in
occupational medicine increased after the training. Students who
frequently attended the lectures scored significantly higher than
sporadic attendees. There was no relation between the level of self-efficacy
and the final knowledge score. CONCLUSIONS: Teaching with the new
occupational medicine module was effective. Lecture attendance is
an important determinant of self-efficacy and performance. Self-efficacy
was not associated with knowledge score. Encouraging classroom participation
may enhance student achievement.
BibTeX:
@article{Braeckman2013a,
  author = {Braeckman, Lutgart and De Clercq, Bart and Janssens, Heidi and Gehanno, Jean-Francois and Bulat, Petar and Pauncu, Elena-Ana and Smits, Paul and van Dijk, Frank and Vanderlinde, Ruben and Valcke, Martin},
  title = {Development and evaluation of a new occupational medicine teaching module to advance self-efficacy and knowledge among medical students.},
  month = {November},
  journal = {Journal of occupational and environmental medicine},
  year = {2013},
  volume = {55},
  number = {11},
  pages = {1276--1280},
  doi = {10.1097/JOM.0b013e3182a50016}
}

Abstract: The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p=0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.
BibTeX:
@article{Delbos2013,
  author = {Delbos, Valérie and Lemée, Ludovic and Bénichou, Jacques and Berthelot, Gilles and Deghmane, Ala-Eddine and Leroy, Jean-Philippe and Houivet, Estelle and Hong, Eva and Taha, Muhamed-Kheir and Caron, François and B14 STOP study group},
  title = {Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.},
  month = {September},
  journal = {Vaccine},
  year = {2013},
  volume = {31},
  pages = {4416--4420},
  doi = {10.1016/j.vaccine.2013.06.080}
}

Abstract: The aim of this study performed in Normandy, France, was to analyze the pharyngeal meningococcal carriage at the peak of a clonal meningococcal B outbreak, which was subsequently controlled using an outer membrane vesicle vaccination. This cross-sectional study included randomly selected subjects aged 1-25 years. Carriers and non carriers were compared using unconditional logistic regression. Among the 3,522 volunteers, there were 196 (standardized rate: 6.46 %) Neisseria meningitidis carriers, of which there were only five with the outbreak strain (B:14:P1.7,16/ST-32; standardized rate: 0.18 %). From the multivariate analysis, older age, smoking, higher degree of socialization, and social deprivation appear to favor the carriage of all the strains included. Prior antibiotic treatment up to 12 months before swabbing, even with β-lactam, was protective against carriage. Our data indicate a low overall meningococcal carriage rate with a surprising protective effect of prior antibiotic exposure. The observed low carriage rate of the epidemic strain (B:14:P1.7,16/ST-32) contrasts with the high incidence of invasive meningococcal diseases (IMD) due to this strain. Hence, our data underline the high virulence of the strain and suggest a low level of natural immunity of the population against this strain. Although highly resource-consuming, carriage studies are helpful in guiding the implementation of control measures of IMD, such as mass vaccination or chemoprophylaxis.
BibTeX:
@article{Delbos2013a,
  author = {Delbos, V and Lemée, L and Bénichou, J and Berthelot, G and Taha, M-K and Caron, F and B14 STOP study group},
  title = {Meningococcal carriage during a clonal meningococcal B outbreak in France.},
  month = {November},
  journal = {European journal of clinical microbiology \& infectious diseases : official publication of the European Society of Clinical Microbiology},
  year = {2013},
  volume = {32},
  pages = {1451--1459},
  doi = {10.1007/s10096-013-1897-6}
}

Abstract: In searches for clinical trials and systematic reviews, it is said
that Google Scholar (GS) should never be used in isolation, but
in addition to PubMed, Cochrane, and other trusted sources of information.
We therefore performed a study to assess the coverage of GS specifically
for the studies included in systematic reviews and evaluate if GS
was sensitive enough to be used alone for systematic reviews.
BibTeX:
@article{Gehanno2013,
  author = {Gehanno, JF and Rollin, L and Darmoni, SJ},
  title = {Is the coverage of google scholar enough to be used alone for systematic reviews},
  month = {January},
  journal = {{BMC} Medical Informatics and Decision Making},
  year = {2013},
  volume = {13},
  number = {1},
  pages = {7},
  url = {http://www.biomedcentral.com/1472-6947/13/7/abstract},
  doi = {10.1186/1472-6947-13-7}
}

Abstract: PURPOSE: General practitioners play or should play a role in occupational
medicine (OM), either in diagnosing occupational diseases or in counseling
on return to work. Nevertheless, their training has been reported
to be insufficient in most single country studies. AIMS: The objectives
of this study were to analyze the content and extent of undergraduate
teaching of OM in European medical schools. METHODS: An e-mail questionnaire
survey of the teaching of OM to undergraduates was undertaken from
December 2010 to April 2011 in all medical schools and medical faculties
listed in 27 European countries (n = 305). RESULTS: Among the 305
universities identified, 135 answered to the questionnaire, giving
a response rate of 44 %. The mean number of hours given to formal
instruction in occupational medicine to medical undergraduates was
25.5 h. Nevertheless, this number of hours varied widely between
countries, but also within countries. Overall, 27 % of medical schools
gave their students 10 h of teaching or less, 52 % 20 h or less
and 69 % 30 h or less. Whereas occupational diseases and principles
of prevention were covered in most schools, disability and return
to work were very poorly represented among the topics that were taught
to students. CONCLUSION: Dedicated undergraduate teaching on occupational
health or OM in European medical schools is present in most medical
schools, usually at a low level, but is very variable between and
within countries. Medical schools across Europe are very unequal
to provide qualifying doctors education on the topics they will frequently
come across in their working lives.
BibTeX:
@article{Gehanno2013a,
  author = {Gehanno, J. F. and Bulat, P. and Martinez-Jarreta, B. and Pauncu, E. A. and Popescu, F. and Smits, P B A. and {van Dijk}, F J H. and Braeckman, L.},
  title = {Undergraduate teaching of occupational medicine in European schools of medicine.},
  month = {Apr},
  journal = {Int Arch Occup Environ Health},
  school = {Department of Occupational Medicine, Rouen University Hospital, 1, rue de Germont, 76000, Rouen, France, jean-francois.gehanno@chu-rouen.fr.},
  year = {2013},
  volume = {87},
  number = {4},
  pages = {397-401},
  url = {http://dx.doi.org/10.1007/s00420-013-0878-5},
  doi = {10.1007/s00420-013-0878-5}
}

Abstract: The objective of this study was to ascertain the performance of syndromic
algorithms for the early detection of patients in healthcare facilities
who have potentially transmissible infectious diseases, using computerised
emergency department (ED) data.A retrospective cohort in an 810-bed
University of Lyon hospital in France was analysed. Adults who were
admitted to the ED and hospitalised between June 1, 2007, and March
31, 2010 were included (N=10895). Different algorithms were built
to detect patients with infectious respiratory, cutaneous or gastrointestinal
syndromes. The performance parameters of these algorithms were assessed
with regard to the capacity of our infection-control team to investigate
the detected cases.For respiratory syndromes, the sensitivity of
the detection algorithms was 82.70 and the specificity was 82.37%.
For cutaneous syndromes, the sensitivity of the detection algorithms
was 78.08 and the specificity was 95.93%. For gastrointestinal
syndromes, the sensitivity of the detection algorithms was 79.41
and the specificity was 81.97%.This assessment permitted us to detect
patients with potentially transmissible infectious diseases, while
striking a reasonable balance between true positives and false positives,
for both respiratory and cutaneous syndromes. The algorithms for
gastrointestinal syndromes were not specific enough for routine use,
because they generated a large number of false positives relative
to the number of infected patients. Detection of patients with potentially
transmissible infectious diseases will enable us to take precautions
to prevent transmission as soon as these patients come in contact
with healthcare facilities.
BibTeX:
@article{Gerbier-Colomban2013,
  author = {Gerbier-Colomban, Solweig and Gicquel, Quentin and Millet, Anne-Laure and Riou, Christophe and Grando, Jacqueline and Darmoni, Stefan and Potinet-Pagliaroli, Véronique and Metzger, Marie-Hélène},
  title = {Evaluation of syndromic algorithms for detecting patients with potentially transmissible infectious diseases based on computerised emergency-department data.},
  journal = {BMC Med Inform Decis Mak},
  school = {Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Unité d'hygiène et d'épidémiologie, F-69317 Lyon, France. solweig.gerbier-colomban@chu-lyon.fr.},
  year = {2013},
  volume = {13},
  pages = {101},
  url = {http://dx.doi.org/10.1186/1472-6947-13-101},
  doi = {10.1186/1472-6947-13-101}
}

Abstract: OBJECTIVE: The objective is to represent the Foundational Model of
Anatomy (FMA) in the OWL 2 Web Ontology Language (informally OWL
2), and to use it in a European cross-lingual portal of health terminologies
for indexing and searching Web resources. Formalizing the FMA in
OWL 2 is essential for semantic interoperability, to improve its
design, and to ensure its reliability and correctness, which is particularly
important for medical applications. METHOD AND MATERIAL: The native
FMA was implemented in frames and stored in a MySQL database backend.
The main strength of the method is to leverage OWL 2 expressiveness
and to rely on the naming conventions of the FMA, to make explicit
some implicit semantics, while improving its ontological model and
fixing some errors. Doing so, the semantics (meaning) of the formal
definitions and axioms are anatomically correct. A flexible tool
enables the generation of a new version in OWL 2 at each Protégé
FMA update. While it creates by default a 'standard' version of the
FMA in OWL 2 (FMA-OWL), many options allow for producing other variants
customized to users' applications. Once formalized in OWL 2, it was
possible to use an inference engine to check the ontology and detect
inconsistencies. Next, the FMA-OWL was used to derive a lightweight
FMA terminology for a European cross-lingual portal of terminologies/ontologies
for indexing and searching resources. The transformation is mainly
based on a reification process. RESULT: Complete representations
of the entire FMA in OWL 1 or OWL 2 are now available. The formalization
tool is flexible and easy to use, making it possible to obtain an
OWL 2 version for all existing public FMA. A number of errors were
detected in the native FMA and several patterns of recurrent errors
were identified in the original FMA. This shows how the underlying
OWL 2 ontology is essential to ensure that the lightweight derived
terminology is reliable. The FMA OWL 2 ontology has been applied
to derive an anatomy terminology that is used in a European cross-lingual
portal of health terminologies. This portal is daily used by librarians
to index Web health resources. In August 2011, 6481 out of 81,450
health resources of CISMeF catalog (http://www.chu-rouen.fr/cismef/
- accessed 29.08.12) (7.96 were indexed with at least one FMA
entity. CONCLUSION: The FMA is a central terminology used to index
and search Web resources. To the best of our knowledge, neither a
complete representation of the entire FMA in OWL 2, nor an anatomy
terminology available in a cross-lingual portal, has been developed
to date. The method designed to represent the FMA ontology in OWL
2 presented in this article is general and may be extended to other
ontologies. Using a formal ontology for quality assurance and deriving
a lightweight terminology for biomedical applications is a general
and promising strategy.
BibTeX:
@article{Golbreich2012,
  author = {Golbreich, C and Grosjean, J and Darmoni, SJ},
  title = {The Foundational Model of Anatomy in OWL 2 and its use.},
  month = {Feb},
  journal = {Artif Intell Med},
  school = {University of Versailles Saint-Quentin, 78035 Versailles, France. Electronic address: cgolbrei@gmail.com.},
  year = {2013},
  volume = {57},
  number = {2},
  pages = {119-132},
  url = {http://dx.doi.org/10.1016/j.artmed.2012.11.002},
  doi = {10.1016/j.artmed.2012.11.002}
}

Abstract: To summarize the best papers in the field of Knowledge Representation
and Management (KRM).A synopsis of the four selected articles for
the IMIA Yearbook 2013 KRM section is provided, as well as highlights
of current KRM trends, in particular, of the semantic web in daily
health practice. The manual selection was performed in three stages:
first a set of 3,106 articles, then a second set of 86 articles followed
by a third set of 15 articles, and finally the last set of four chosen
articles.Among the four selected articles (see Table 1), one focuses
on knowledge engineering to prevent adverse drug events; the objective
of the second is to propose mappings between clinical archetypes
and SNOMED CT in the context of clinical practice; the third presents
an ontology to create a question-answering system; the fourth describes
a biomonitoring network based on semantic web technologies.These
four articles clearly indicate that the health semantic web has become
a part of daily practice of health professionals since 2012. In the
review of the second set of 86 articles, the same topics included
in the previous IMIA yearbook remain active research fields: Knowledge
extraction, automatic indexing, information retrieval, natural language
processing, management of health terminologies and ontologies.
BibTeX:
@article{Griffon2013,
  author = {Griffon, N. and Charlet, J. and Darmoni, Sj and , Section Editors for the I. M. I. A Yearbook 2013, Section on Knowledge Representation and Management},
  title = {Knowledge representation and management: towards an integration of a semantic web in daily health practice.},
  journal = {Yearb Med Inform},
  school = {Rouen University Hospital, Department of BioMedical Informatics, 1 rue de Gérmont, 76031 Rouen Cedex, France. E-mail: stefan.darmoni@chu-rouen.fr.},
  year = {2013},
  volume = {8},
  number = {1},
  pages = {155--158}
}

Abstract: To assess the safety and immunogenicity of live attenuated yellow fever (YF) 17D vaccine in adults receiving systemic corticosteroid therapy. All adult travelers on systemic corticosteroid therapy who had received the YF17D vaccine in 24 French vaccination centers were prospectively enrolled and matched with healthy controls (1:2) on age and history of YF17D immunization. Safety was assessed in a self-administered standardized questionnaire within 10 days after immunization. YF-specific neutralizing antibody titers were measured 6 months after vaccination in patients receiving corticosteroids. Between July 2008 and February 2011, 102 vaccine recipients completed the safety study (34 receiving corticosteroids and 68 controls). The median age was 54.9 years (interquartile range [IQR] 45.1-60.3 years) and 45 participants had a history of previous YF17D immunization. The median time receiving corticosteroid therapy was 10 months (IQR 1-67 months) and the prednisone or equivalent dosage was 7 mg/day (IQR 5-20). Main indications were autoimmune diseases (n = 14), rheumatoid arthritis (n = 9), and upper respiratory tract infections (n = 8). No serious adverse event was reported; however, patients receiving corticosteroids reported more frequent moderate/severe local reactions than controls (12% and 2%, respectively; relative risk 8.0, 95% confidence interval 1.4-45.9). All subjects receiving corticosteroids who were tested (n = 20) had neutralizing antibody titers >10 after vaccination. After YF17D immunization, moderate/severe local reactions may be more frequent in patients receiving systemic corticosteroid therapy. Immunogenicity seems satisfactory. Large-scale studies are needed to confirm these results.
BibTeX:
@article{Kerneis2013,
  author = {Kernéis, Solen and Launay, Odile and Ancelle, Thierry and Iordache, Laura and Naneix-Laroche, Véronique and Méchaï, Frédéric and Fehr, Thierry and Leroy, Jean-Philippe and Issartel, Bertrand and Dunand, Jean and van der Vliet, Diane and Wyplosz, Benjamin and Consigny, Paul-Henri and Hanslik, Thomas},
  title = {Safety and immunogenicity of yellow fever 17D vaccine in adults receiving systemic corticosteroid therapy: an observational cohort study.},
  month = {September},
  journal = {Arthritis care \& research},
  year = {2013},
  volume = {65},
  pages = {1522--1528},
  doi = {10.1002/acr.22021}
}

Abstract: To help clinicians read medical texts such as clinical practice guidelines
or drug monographs, we proposed an iconic language called VCM. This
language can use icons to represent the main medical concepts, including
diseases, symptoms, treatments and follow-up procedures, by combining
various pictograms, shapes and colors. However, the semantics of
this language have not been formalized, and users may create inconsistent
icons, e.g. by combining the "tumor" shape and the "sleeping" pictograms
into a "tumor of sleeping" icon.This work aims to represent the VCM
language using DLs and OWL for evaluating its semantics by reasoners,
and in particular for determining inconsistent icons. We designed
an ontology for formalized the semantics of VCM icons using the Protégé
editor and scripts for translating the VCM lexicon in OWL. We evaluated
the ability of the ontology to determine icon consistency for a set
of 100 random icons. The evaluation showed good results for determining
icon consistency, with a high sensitivity. The ontology may also
be useful for the design of mapping between VCM and other medical
terminologies, for generating textual labels for icons, and for developing
user interfaces for creating VCM icons.
BibTeX:
@article{Lamy2012,
  author = {Lamy, Jean-Baptiste and Soualmia, Lina F. and Kerdelhué, Gaëtan and Venot, Alain and Duclos, Catherine},
  title = {Validating the semantics of a medical iconic language using ontological reasoning.},
  month = {Sep},
  journal = {J Biomed Inform},
  school = {BIO (EA3969), UFR SMBH, University Paris 13, Sorbonne Paris Cité, Bobigny, France. Electronic address: jean-baptiste.lamy@univ-paris13.fr.},
  year = {2013},
  volume = {46},
  number = {1},
  pages = {56-67},
  url = {http://dx.doi.org/10.1016/j.jbi.2012.08.006},
  doi = {10.1016/j.jbi.2012.08.006}
}

Abstract: To summarize excellent current research in the field of Bioinformatics
and Translational Informatics with application in the health domain
and evidence-based medicine.We provide a synopsis of the articles
selected for the IMIA Yearbook 2013, from which we attempt to derive
a synthetic overview of current and future activities in the field.
Three steps of selection were performed by querying PubMed and Web
of Science. A first set of 5,549 articles was refined into a second
set of 1,272 articles from which 15 articles were retained for peer-review.The
selection and evaluation process of this Yearbook's section on Bioinformatics
and Translational Informatics yielded four excellent articles regarding
the Human Genome and Medicine. Exploiting genomic data depends on
having the appropriate reference annotation available. In the first
article, the goal of the GENCODE Consortium is to produce and publish
The GENCODE human reference gene set. As a result it is composed
by merged manual and automatic annotations, which are frequently
updated from public experimental databases. The quality of genome
sequencing is platform-dependant. In the second article, a generic
database independent from the sequencing technologies, Huvariome,
can help to identify errors and inconsistencies in sequencing. To
understand complex diseases of patients it will be of great importance
to detect rare gene variants. This is the aim of the third study.
Finally, in the last article, the plasma's DNA of healthy individual
and patients suffering from cancer is compared.The current research
activities attest to the continuous convergence of Bioinformatics
and Medical Informatics for clinical practice. For instance, a direct
use of high throughput sequencing technologies for patients could
aid the diagnosis of complex diseases (such as cancer) without invasive
surgery (such as biopsy) but only with blood analysis. However, ongoing
genomic tests will generate massive amounts of data and will imply
new trends in the near future: "Big Data" and smart health management.
BibTeX:
@article{Lecroq2013,
  author = {Lecroq, T. and Soualmia, L. F. and , Section Editors for the I. M. I. A Yearbook Section on Bioinformatics and Translational Informatics},
  title = {From genome sequencing to bedside. Findings from the section on bioinformatics and translational informatics.},
  journal = {Yearb Med Inform},
  school = {Health, 76821 Mont-Saint-Aignan Cedex, France. E-mail: Thierry.lecroq@univ-rouen.fr.},
  year = {2013},
  volume = {8},
  number = {1},
  pages = {175--177}
}

Abstract: BACKGROUND: Antidepressants (ADs) are commonly prescribed in primary
care and are mostly indicated for depression. According to the literature,
they are now more frequently prescribed for health conditions other
than psychiatric ones. Due to their many indications in a wide range
of medical fields, assessing the appropriateness of AD prescription
seems to be a challenge for GPs. The aim of this study was to review
evidence from guidelines for antidepressant prescription for non-psychiatric
conditions in Primary Care (PC) settings. METHODS: Data were retrieved
from French, English and US guideline databases. Guidelines or reviews
were eligible if keywords regarding 44 non-psychiatric conditions
related to GPs' prescription of ADs were encountered. After excluding
psychiatric and non-primary care conditions, the guidelines were
checked for keywords related to AD use. The latest updated version
of the guidelines was kept. Recent data was searched in the Cochrane
Database of Systematic Reviews and in PubMed for updated reviews
and randomized control trials (RCTs). RESULTS: Seventy-eight documents
were retrieved and were used to assess the level of evidence of a
potential benefit to prescribing an AD. For 15 conditions, there
was a consensus that prescribing an AD was beneficial. For 5 others,
ADs were seen as potentially beneficial. No proof of benefit was
found for 15 conditions and proof of no benefit was found for the
last 9. There were higher levels of evidence for pain conditions,
(neuropathic pain, diabetic painful neuropathy, central neuropathic
pain, migraine, tension-type headaches, and fibromyalgia) incontinence
and irritable bowel syndrome. There were difficulties in summarizing
the data, due to a lack of information on the level of evidence,
and due to variations in efficacy between and among the various classes
of ADs. CONCLUSIONS: Prescription of ADs was found to be beneficial
for many non-psychiatric health conditions regularly encountered
in PC settings. On the whole, the guidelines were heterogeneous,
seemingly due to a lack of trials assessing the role of ADs in treatment
strategies.
BibTeX:
@article{Mercier2013,
  author = {Mercier, Alain and Auger-Aubin, Isabelle and Lebeau, Jean-Pierre and Schuers, Matthieu and Boulet, Pascal and Hermil, Jean-Loup and Van Royen, Paul and Peremans, Lieve},
  title = {Evidence of prescription of antidepressants for non-psychiatric conditions in primary care: an analysis of guidelines and systematic reviews.},
  month = {May},
  journal = {BMC family practice},
  year = {2013},
  volume = {14},
  pages = {55},
  doi = {10.1186/1471-2296-14-55}
}

Abstract: BACKGROUND: Data about perceived needs of workers for information
on occupational hazards or diseases (OHDs) are scarce and the behaviour
of workers seeking information on these matters is not well known.
AIMS: To describe workers' needs and behaviour in seeking information
about OHDs. METHODS: All workers attending for consultation at an
occupational health service in Upper Normandy within 1 week were
invited to fill in an anonymous questionnaire. RESULTS: Of the 2640
workers responding 58% declared a need for information about OHD,
but only 37% actually sought that information. Whereas 82% of workers
mentioned the internet and their general physician (GP) as sources
of information on OHD, only 43% mentioned their occupational physician
(OP). Furthermore, information received from OPs was not considered
more reliable than that from GPs. CONCLUSIONS: Workers report a need
for information about OHDs. Although most of them trust information
given by OPs, they do not use OPs to obtain OHD information, but
instead use less reliable sources such as the internet or their GPs.
BibTeX:
@article{Rollin2013a,
  author = {Rollin, L. and Ladner, J. and Gislard, A. and Monfrin, F. and Larchevesque, J.-Y. and Deslandes, P. and Gehanno, J.-F.},
  title = {Hazard information needs and information seeking in {French} workers.},
  month = {October},
  journal = {Occupational medicine (Oxford, England)},
  year = {2013},
  volume = {63},
  number = {7},
  pages = {473--478},
  doi = {10.1093/occmed/kqt091}
}

BibTeX:
@article{Soualmia2013,
  author = {Soualmia, LF and Sakji, S and Letord, C and Rollin, L and Massari, P and Darmoni, SJ},
  title = {Improving information retrieval with multiple health terminologies in a quality-controlled gateway},
  journal = {BMC Health Information Science and Systems},
  year = {2013},
  pages = {1-8},
  url = {http://www.hissjournal.com/content/1/1/8},
  doi = {10.1186/2047-2501-1-8}
}

BibTeX:
@article{Trost2013,
  author = {Trost, O. and Peron, J.-M.},
  title = {Re: "{Treatment} of low subcondylar fractures--a 5-year retrospective study".},
  month = {December},
  journal = {International journal of oral and maxillofacial surgery},
  year = {2013},
  volume = {42},
  number = {12},
  pages = {1596--1597},
  doi = {10.1016/j.ijom.2013.08.017}
}

BibTeX:
@article{Marie2013,
  author = {Marie, I. and Gehanno, J.F. and Bubenheim, M. and Duval-Modeste, A.B. and Dominique, S. and Joly, P. and Bravard, P. and Noel, D. and Weber, J. and Benichou, J. and Levesque, H.},
  title = {Sclérodermie systémique et facteurs environnementaux : enquête prospective de 100 patients et 300 témoins},
  journal = {La Revue de médecine interne},
  year = {2013},
  volume = {34},
  pages = {A31--A32},
  doi = {10.1016/j.revmed.2013.10.034}
}

BibTeX:
@article{Marie2013a,
  author = {Marie, I. and Gehanno, J.-F. and Bubenheim, M. and Duval-Modeste, A.-B. and Joly, P. and Dominique, S. and Noel, D. and Bravard, P. and Lagoutte, P. and Cailleux, A.-F. and Weber, J. and Levesque, H.},
  title = {Sclérodermie systémique et facteurs environnementaux : enquête prospective cas-témoins},
  journal = {La Revue de médecine interne},
  year = {2013},
  volume = {34},
  pages = {A63--A63},
  doi = {10.1016/j.revmed.2013.03.283}
}

BibTeX:
@article{Pairon2013,
  author = {Pairon, J.C. and Gehanno, J.F. and Paris, C.},
  title = {Le mésusage des substances psychoactives en milieu de travail : un besoin de recommandations pour les acteurs des équipes de santé au travail},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2013},
  volume = {74},
  number = {3},
  pages = {238--239},
  doi = {10.1016/j.admp.2013.04.008}
}

Abstract: This prospective survey, conducted at the Dakar airport from August 18, 2011, to May 8, 2012, asked a sample of travelers living in France and returning there after a stay in Senegal to complete a questionnaire. The aim of the study was to assess the determinants of vaccination coverage against yellow fever. The study included 10 298 travelers, with a median age of 48 years (interquartile range: 27-58); 52% were tourists, and 22% were traveling for business purposes. The measured level of anti-yellow fever vaccination coverage was 39.3%. Vaccination coverage was influenced by the travelers' level of knowledge and their perception of the risk.
BibTeX:
@article{Rapp2013,
  author = {Rapp, C and Fall, K B and Tall, A and Michel, R and Royon, P and de Gentile, L and Leroy, J P and Caumes, E and Bouchaud, O},
  title = {Évaluation de la couverture vaccinale des voyageurs se rendant en zone d'endémicité amarile (Sénégal).},
  month = {May},
  journal = {Medecine et sante tropicales},
  year = {2013},
  volume = {23},
  pages = {236},
  doi = {10.1684/mst.2013.0207}
}

Abstract: Contexte. Depuis le rapport de la Global INItiative for Asthma (GINA)
en 2006, le niveau de contrôle guide la prise en charge des patients
asthmatiques. Cette maladie chronique nécessite une approche globale.
De nombreuses études ont évalué la prise en charge pharmacologique
de la maladie, mais peu ont étudié les mesures non médicamenteuses.Objectif.
Identifier les interventions permettant d’améliorer le contrôle de
l’asthme, en dehors des thérapies médicamenteuses spécifiques validées.Méthode.
Revue systématique de la littérature menée en juin 2013 dans Medline
et la Cochrane Library.Résultats. Les programmes d’éducation thérapeutique
amélioraient significativement le contrôle de l’asthme. Il était
toutefois difficile d’identifier les types de programme les plus
efficaces. La plupart des mesures visant à réduire l’exposition aux
acariens étaient inefficaces. Les systèmes de purification d’air
par filtration semblaient plus efficaces que les systèmes par ioniseur.
La réhabilitation totale ou partielle des logements visant à réduire
l’exposition aux allergènes et polluants intérieurs permettait d’améliorer
le contrôle. Aucune adaptation du régime alimentaire ne s’est révélée
efficace. L’activité physique a montré des résultats encourageants
mais non significatifs. Le traitement du reflux gastro-oesophagien
et la prescription d’antibiotiques au long cours n’ont pas permis
d’améliorer le contrôle de l’asthme. Les interventions psychologiques
ou de physiothérapie n’ont généralement pas fait la preuve de leur
efficacité. Le transfert de la prise en charge du médecin vers une
infirmière n’a pas montré de résultats concluants. La prise en charge
des enfants asthmatiques en milieu scolaire s’est révélée efficace.
Les interventions complexes, qui associaient généralement des programmes
d’éducation thérapeutique à une diminution de l’exposition aux allergènes
et polluants intérieurs, amélioraient significativement le contrôle
de la maladie.Conclusion. Quelques interventions non médicamenteuses
ont prouvé une amélioration du contrôle de l’asthme. Les interventions
complexes qui coordonnent des professionnels de soins primaires autour
du patient semblent les plus efficaces.
BibTeX:
@article{Schuers2013,
  author = {Schuers, M. and Chapron, A and Bouchez, T and Darmon, D},
  title = {Interventions sur les facteurs associés au contrôle de l’asthme : une revue systématique de la littérature},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2013},
  number = {109},
  pages = {224--35}
}

Abstract: ContextePour valider le diplôme d’études spécialisées (DES) de médecine
générale, le département de médecine générale de Rouen a choisi,
en 1997, une approche par objectifs. Il s’est inspiré des évaluations
du Collège des médecins de famille du Canada en développant l’examen
clinique objectif standardisé (ECOS)1. Cet examen oral est organisé
en plusieurs stations de 7 minutes. Chacune propose à l’interne une
situation clinique particulière, avec un objectif précis. L’interne
est face à un patient simulé et un observateur qui l’évalue suivant
une grille d’observation. Chaque situation évalue une ou plusieurs
compétences. L’ensemble permet une évaluation globale des compétences
suivantes : la démarche diagnostique de l’entretien, de l’examen
clinique, paraclinique, les gestes techniques, la prise en charge
thérapeutique et la communication (information du patient, relation
médecin-patient).
BibTeX:
@article{Secret2013,
  author = {Secret, J and Schuers, M.},
  title = {Impact du {SASPAS} sur les performances des internes aux {ECOS}},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2013},
  number = {106 suppl 2},
  pages = {58--9}
}

Abstract: The partial match between biomedical documents and controlled vocabularies
allows to find in the documents more terms variants than those existing
in the dictionaries. However, it generates irrelevant information.
We propose a new approach for indexing biomedical documents with
the Medical Subject Headings (MeSH) thesaurus that aims to overcome
the limitation of the partial match. In fact, our indexing approach
proposes to restrict the stemming process in the step of pretreatment.
The step of the descriptors extraction is based essentially on the
vector space model and combines semantic and statistic methods to
compute a score to estimate the relevance of a descriptor given a
document. The knowledge provided by the Unified Medical Language
System (UMLS) is used then for filtering. The filtering method aims
to keep only relevant descriptors. The experiments of our approach
that have been carried out on the OHSUMED collection, showed very
encouraging results.
BibTeX:
@inproceedings{Chebil2013,
  author = {Chebil, W and Soualmia, LF and Darmoni, SJ},
  title = {BioDI: A new approach to improve Biomedical Documents Indexing},
  booktitle = {Proceedings of the 24th International Conference on Database and Expert Systems Applications, DEXA},
  month = {August},
  publisher = {Springer},
  year = {2013},
  series = {Lecture Notes in Computer Science},
  pages = {78-87},
  doi = {10.1007/978-3-642-40285-2_9}
}

BibTeX:
@inproceedings{Chebil2013a,
  author = {Chebil, W and Soualmia, LF and Darmoni, SJ},
  title = {BNDI:A Bayesian Network for biomedial Documents Indexing with MeSH thesaurus},
  booktitle = {Proceedings of the International Conference on Reasoning and Optimization in Information Systems (ROIS)},
  address = {Hammam- Sousse, Tunisia},
  month = {September},
  year = {2013},
  pages = {134-139}
}

BibTeX:
@inproceedings{Dupuch2013,
  author = {Dupuch, M and Segond, F and Bittar, A and Dini, L and Soualmia, LF and Darmoni, SJ and Gicquel, Q and Metzger, MH},
  title = {Separate the grain from the chaff: make the best use of language and knowledge technologies to model textual medical data extracted from electronic health records},
  booktitle = {Proceedings of the LTC'13 6th Language \& Technology Conference: Human Language Technologies as a Challenge for Computer Science and Linguistics},
  address = {Poznań, Poland},
  month = {December},
  year = {2013}
}

BibTeX:
@inproceedings{Merabti2013b,
  author = {Merabti, A and Soualmia, LF and Darmoni, SJ},
  title = {Aligning bio-terminologies and bio-ontologies lexicons : a preliminary study},
  booktitle = {Proceedings of the 10th International Conference on Terminology and Artificial Intelligence},
  month = {October},
  year = {2013}
}

Abstract: The objective of this study is to evaluate to approaches assisting
the translation of SNOMED CT into French. Two types of approaches
were combined: a concept-based one, which relies on conceptual information
of the UMLS Metathesaurus and a lexical-based one, which relieson
NLP techniques. In addition to the French terminologies (whether
included in UMLS or not). Using the concept-based approach, a set
of 156,157 (39.4 SNOMED CT terms were translated to at least one
French term from UMLS. Expanded to the French terms from UMLS terminologies
translated by CISMeF, 2,548 (+0.7 additional SNOMED CT terms were
translated to at least one French term. Using the lexical-based approach,
a set of 145,737 (36.8 SNOMED CT terms were translated to at least
one French term from HeTOP. The qualitative evaluation showed that
44% of the translations were rated as "relevant". Overall, the two
approaches have provided the translation of 168,750 (42.6 SNOMED
CT terms into French using different bilingual terminological sources
included in UMLS or in HeTOP.
BibTeX:
@inproceedings{Merabti2013a,
  author = {Merabti, T and Soualmia, LF. and Grosjean, J and Letord, C and Darmoni, SJ},
  title = {Assisting the Translation of SNOMED CT into French.},
  booktitle = {MEDINFO 2013 - Proceedings of the 14th World Congress on Medical Informatics},
  journal = {Stud Health Technol Inform},
  school = {TIBS, LITIS EA 4108, Rouen University Hospital, Rouen, France.},
  year = {2013},
  volume = {192},
  pages = {47--51}
}

BibTeX:
@inproceedings{Darmoni2013,
  author = {Darmoni, SJ and Soualmia, LF and Griffon, N and Grosjean, J and Kerdelhué, G and Kergoulay, I and Thirion, B and Dahamna, B},
  title = {MLPubMed : une base de données bibliographique multi-lingue},
  booktitle = {Colloque RITS},
  year = {2013}
}

BibTeX:
@inproceedings{Darmoni2013a,
  author = {Darmoni, SJ and Soualmia, LF and Griffon, N and Kerdelhué, G and Kergourlay, I and Thirion, B and Dahamna, B},
  title = {MLPubMed : une base de données bibliographique multi-lingue},
  booktitle = {Pré-symposium French Special Interest Group of the International Medical Informatics Association, FR SIG IMIA},
  month = {August},
  year = {2013}
}

BibTeX:
@inproceedings{Giquel2013,
  author = {Giquel, Q and Dini, L and Kergourlay, I and Arnod-Prin, P and Chariout, S and Bittar, A and Soualmia, LF and Guedez, P and Segond, F and Ruhlman, M and Darmoni, SJ and Metzger, M},
  title = {SYstème de Normalisation et d'Organisation de Données médicales textuelles pour l'Observation en Santé (SYNODOS)},
  booktitle = {Pré-symposium French Special Interest Group of the International Medical Informatics Association, FR SIG IMIA},
  month = {August},
  year = {2013}
}

BibTeX:
@inproceedings{Neveol2013,
  author = {Névéol, A and Grouin, C and and Darmoni, SJ and Zweigenbaum, P},
  title = {Dé-identification d’un corpus clinique pour le traitement automatique du français},
  booktitle = {Pré-symposium French Special Interest Group of the International Medical Informatics Association, FR SIG IMIA},
  month = {August},
  year = {2013}
}

Abstract: PubMed contains many articles in languages other than English but
it is difficult to find them using the English version of the Medical
Subject Headings (MeSH) Thesaurus. The aim of this work is to propose
a tool allowing access to a PubMed subset in one language, and to
evaluate its performance. Translations of MeSH were enriched and
gathered in the information system. PubMed subsets in main European
languages were also added in our database, using a dedicated parser.
The CISMeF generic semantic search engine was evaluated on the response
time for simple queries. MeSH descriptors are currently available
in 11 languages in the information system. All the 654,000 PubMed
citations in French were integrated into CISMeF database. None of
the response times exceed the threshold defined for usability (2
seconds). It is now possible to freely access biomedical literature
in French using a tool in French; health professionals and lay people
with a low English language may find it useful. It will be expended
to several European languages: German, Spanish, Norwegian and Portuguese.
BibTeX:
@inproceedings{Darmoni2013b,
  author = {Darmoni, SJ. and Soualmia, LF and Griffon, N and Grosjean, J and Kerdelhué, G and Kergourlay, I and Dahamna, B},
  title = {Multi-lingual Search Engine to Access PubMed Monolingual Subsets: A Feasibility Study.},
  booktitle = {MEDINFO 2013 - Proceedings of the 14th World Congress on Medical Informatics},
  journal = {Stud Health Technol Inform},
  school = {TIBS, LITIS EA 4108, Rouen University Hospital, Rouen, France.},
  year = {2013},
  volume = {192},
  pages = {966}
}

Abstract: The Human Phenotype Ontology (HPO) is a controlled vocabulary which
provides phenotype data related to genes or diseases. The Health
Terminology/Ontology Portal (HeTOP) is a tool dedicated to both human
beings and computers to access and browse biomedical terminologies
or ontologies (T/O). The objective of this work was to integrate
the HPO into HeTOP in order to enhance both works. This integration
is a success and allows users to search and browse the HPO with a
dedicated interface. Furthermore, the HPO has been enhanced with
the addition of content such as new synonyms, translations, mappings.
Integrating T/O such as the HPO into HeTOP is a benefit to vocabularies
because it allows enrichment of them and it is also a benefit for
HeTOP which provides a better service to both humans and machines.
BibTeX:
@inproceedings{Grosjean2013,
  author = {Grosjean, J and Merabti, T and Soualmia, LF and Letord, C and Charlet, J and Robinson, P and Darmoni, SJ},
  title = {Integrating the Human Phenotype Ontology into HeTOP Terminology-Ontology Server.},
  booktitle = {MEDINFO 2013 - Proceedings of the 14th World Congress on Medical Informatics},
  journal = {Stud Health Technol Inform},
  school = {TIBS, LITIS EA 4108, Rouen University Hospital, Rouen, France.},
  year = {2013},
  volume = {192},
  pages = {961}
}

BibTeX:
@inproceedings{Merabti2013,
  author = {Merabti, A and Soualmia, LF and Darmoni, SJ},
  title = {Mise en correspondance de terminologies et ontologies biomédicales pour un accès facilité aux connaissances},
  booktitle = {13e Conférence Francophone sur l'Extraction et la Gestion des Connaissances (EGC'13)},
  year = {2013}
}

Abstract: The concept-oriented structure of the MeSH® thesaurus is not yet in
common use. Nevertheless, it has been shown that a concept-based
querying of PubMed may be of interest. To take full advantage of
the concept-oriented structure of MeSH in the information retrieval
tool associated with the CISMeF catalogue, it was necessary to translate
such concepts into French.
BibTeX:
@inproceedings{Soualmia2013a,
  author = {Soualmia, Lina F. and Letord, Catherine and Merabti, Tayeb and Griffon, Nicolas and Manel, Jacques and Darmoni, Stéfan J.},
  title = {Translating MeSH Concepts.},
  booktitle = {MEDINFO 2013 - Proceedings of the 14th World Congress on Medical Informatics},
  journal = {Stud Health Technol Inform},
  school = {CISMeF, Rouen University Hospital, Rouen, France.},
  year = {2013},
  volume = {192},
  pages = {1007}
}

BibTeX:
@phdthesis{griffon2013,
  author = {N. Griffon},
  title = {Modélisation, création et évaluation de flux de terminologies et de terminologies d'interface : application à  la production d'examens complémentaires de biologie et d'imagerie médicale},
  school = {University of Rouen, France},
  year = {2013},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2017/01/Thèse_NG_10-25_these.pdf}
}

BibTeX:
@phdthesis{Rollin2013,
  author = {Laetitia Rollin},
  title = {L’accès à la connaissance et qualité de l’information en santé au travail},
  year = {2013}
}

2012


Abstract: A meningococcal B:14:P1.7,16 outbreak in Normandy (France) was recently controlled using MenBvac, an outer membrane vesicle vaccine previously designed against the B:15:P1.7,16 strain. The further emergence of a new B:14:P1.7,16 outbreak in another district in Normandy led us to explore immunity against B:14:P1.7,16 before and after the MenBvac campaign using a 2+1 (day 0, week 6, month 8) schedule. Children (1-5 years) were sampled before, during and up to one year after vaccination. Serum bactericidal activity against B:14:P1.7,16 was titrated using human complement (hSBA) and immune response was defined by hSBA titer ≥4 as a surrogate for protection. The percentage of hSBA titer ≥4 was 10.8% before vaccination, raised to 84.1% 6 weeks after the completion of the schedule, but declined to 39.7% one year later. This level is lower than the targeted 60% level and suggests only short-term persistence of response against B:14:P1.7,16 using this schedule.
BibTeX:
@article{Caron2012,
  author = {Caron, François and Delbos, Valérie and Houivet, Estelle and Deghmane, Ala-Eddine and Leroy, Jean-Philippe and Hong, Eva and Bénichou, Jacques and Taha, Muhamed-Kheir},
  title = {Evolution of immune response against Neisseria meningitidis B:14:P1.7,16 before and after the outer membrane vesicle vaccine MenBvac.},
  month = {July},
  journal = {Vaccine},
  year = {2012},
  volume = {30},
  pages = {5059--5062},
  doi = {10.1016/j.vaccine.2012.05.051}
}

BibTeX:
@article{Coutant2012a,
  author = {Coutant, S and Cabot, C and Lefebvre, A and Léonard, M and Prieur-Gaston, E and Campion, D and Lecroq, T and Dauchel, H},
  title = {EVA: Exome Variation Analyzer, an efficient and versatile tool for filtering strategies in medical genomics},
  journal = {BMC Bioinformatics},
  year = {2012},
  volume = {13},
  number = {Suppl 14},
  pages = {S9},
  url = {http://www.biomedcentral.com/1471-2105/13/S14/S9},
  doi = {10.1186/1471-2105-13-S14-S9}
}

BibTeX:
@article{Darmoni2012a,
  author = {Darmoni, SJ and Soualmia, LF and Letord, C and Griffon, N and Jaulent, MC and Thirion, B and Névéol, A},
  title = {Improving information retrieval using MeSH Concepts: a test case on rare and chronic diseases},
  journal = {J Med Libr Assoc},
  year = {2012},
  volume = {100},
  number = {3},
  pages = {176-83},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411256/pdf/mlab-100-03-176.pdf},
  doi = {10.3163/1536-5050.100.3.007}
}

BibTeX:
@article{Gehanno2012,
  author = {Gehanno, JF and Rollin, L and Ladner, J and Darmoni, SJ},
  title = {How is Occupational Medicine represented in the major journals in general medicine?},
  month = {June},
  journal = {Occupational and Environmental Medicine},
  year = {2012},
  volume = {69},
  number = {8},
  pages = {603-5},
  doi = {10.1136/oemed-2011-100044}
}

BibTeX:
@article{Gehanno2012a,
  author = {Gehanno, Jean-François and Rollin, Laetitia},
  title = {Influenza vaccination coverage among health professionals before and after the {A(H1N1)} influenza pandemic in France},
  month = {July},
  journal = {Infection control and hospital epidemiology: the official journal of the Society of Hospital Epidemiologists of America},
  year = {2012},
  volume = {33},
  number = {7},
  pages = {757--758},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/22669240},
  doi = {10.1086/666338}
}

Abstract: BACKGROUND: PubMed is the main access to medical literature on the
Internet. In order to enhance the performance of its information
retrieval tools, primarily non-indexed citations, the authors propose
a method: expanding users' queries using Unified Medical Language
System's (UMLS) synonyms i.e. all the terms gathered under one unique
Concept Unique Identifier.

METHODS: This method was evaluated using queries constructed to emphasize
the differences between this new method and the current PubMed automatic
term mapping. Four experts assessed citation relevance.

RESULTS: Using UMLS, we were able to retrieve new citations in 45.5%
of queries, which implies a small increase in recall. The new strategy
led to a heterogeneous 23.7% mean increase in non-indexed citation
retrieved. Of these, 82% have been published less than 4 months earlier.
The overall mean precision was 48.4% but differed according to the
evaluators, ranging from 36.7% to 88.1% (Inter rater agreement was
poor: kappa = 0.34).

CONCLUSIONS: This study highlights the need for specific search tools
for each type of user and use-cases. The proposed strategy may be
useful to retrieve recent scientific advancement.
BibTeX:
@article{Griffon2012,
  author = {Griffon, N and Chebil, W and Rollin, L and Kerdelhue, G and Thirion, B and Gehanno, JF and Darmoni, SJ},
  title = {Performance evaluation of Unified Medical Language System®'s synonyms expansion to query PubMed},
  month = {Feb},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2012},
  volume = {12},
  number = {1},
  pages = {12},
  doi = {10.1186/1472-6947-12-12}
}

Abstract: Objectives: To analyze the attitude of physicians towards alertin
g in CPOE systems in different hospitals in different countries,
addressing various organizational and technical settings and the
view of physicians not currently using a CPOE.Methods: A cross-sectional
quantitative and qualitative questionnaire survey. We invited 2,600
physicians in eleven hospitals from nine countries to participate.
Eight of the hospitals had different CPOE systems in use, and three
of the participating hospitals were not using a CPOE system.Results:
1,018 physicians participated. The general attitude of the physicians
towards CPOE alerting is positive and is found to be mostly independent
of the country, the specific organizational settings in the hospitals
and their personal experience with CPOE systems. Both quantitative
and qualitative results show that the majority of the physicians,
both CPOE-users and non-users, appreciate the benefits of alerting
in CPOE systems on medication safety. However, alerting should
be better adapted to the clinical context and make use of more sophisticated
ways to present alert information. The vast majority of physicians
agree that additional information regarding interactions is useful
on demand. Around half of the respondents see possible alert overload
as a major problem; in this regard, physicians in hospitals with
sophisticated alerting strategies show partly better attitude scores.Conclusions:
Our results indicate that the way alerting information is presented
to the physicians may play a role in their general attitude towards
alerting, and that hospitals with a sophisticated alerting strategy
with less interruptive alerts tend towards more positive attitudes.
This aspect needs to be further investigated in future studies.
BibTeX:
@article{jung_attitude_2012,
  author = {Jung, M and Hoerbst, A and Hackl, W O and Kirrane, F and Borbolla, D and Jaspers, M W M and Oertle, M and Koutkias, V and Ferret, L and Massari, P and Lawton, K and Riedmann, D and Darmoni, S and Maglaveras, N and Lovis, C and Ammenwerth, E},
  title = {Attitude of Physicians Towards Automatic Alerting in Computerized Physician Order Entry Systems. A Comparative International Survey},
  month = {November},
  journal = {Methods of information in medicine},
  year = {2012},
  volume = {52},
  number = {2},
  pages = {99-108},
  doi = {10.3414/ME12-02-0007}
}

Abstract: Background Research on return to work (RTW) is increasing. It is
important to benefit from studies originating from different countries
since certain factors influencing the RTW process are specific
to each country.Aims To compare RTW research in Europe with the
USA and to describe research on RTW in Europe.Methods Medline
was scanned with specific search strings to identify studies concerning
RTW in Europe, in the USA and in the rest of the world. Characteristics
of the European studies were analyzed with two specific tools for
bibliometrics research.Results Four thousand five hundred and twenty-five
studies were identified (1100, 1005 and 2420 coming from Europe,
the USA and the rest of the world, respectively). The European
countries producing the greatest number of research papers standardized
for population of that country were Sweden, the Netherlands, Finland
and Denmark. Sweden was 5.7 times more prolific than the USA. Specialties
covered by the European publications included occupational medicine
(the subject of 66% of the articles), neurology (36, environment
and public health (32, physical medicine and rehabilitation (26
and rheumatology (24.Conclusions There is a worldwide trend
upwards in the number of publications on RTW. Europe recently overtook
the USA in the number of publications per head of population, although
there were large differences in publication rates among the European
countries. The publications of European researchers on RTW are
spread over a wide variety of journals, making access to this research
difficult.
BibTeX:
@article{Rollin2012,
  author = {Rollin, L. and Gehanno, {J.-F.}},
  title = {Research on return to work in European Union countries},
  month = {January},
  journal = {Occupational Medicine},
  year = {2012},
  volume = {62},
  number = {3},
  pages = {210-5},
  url = {http://occmed.oxfordjournals.org/content/early/2012/01/12/occmed.kqr207.abstract},
  doi = {10.1093/occmed/kqr207}
}

BibTeX:
@article{Soualmia2012,
  author = {Soualmia, LF and Prieur-Gaston, E and Moalla, Z and Lecroq, T and Darmoni, SJ},
  title = {Matching health information seekers' queries to medical terms.},
  journal = {BMC Bioinformatics},
  year = {2012},
  volume = {13},
  number = {Suppl 14},
  pages = {S11},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439674/},
  doi = {10.1186/1471-2105-13-S14-S11}
}

BibTeX:
@article{Chebil2012,
  author = {Chebil, W and Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {Indexation automatique de documents en santé : évaluation et analyse de sources d'erreurs},
  journal = {IRBM, Ingénierie et Recherche Biomédicale / IRBM BioMedical Engineering and Research},
  year = {2012},
  volume = {33},
  number = {5-6},
  pages = {316-329},
  doi = {10.1016/j.irbm.2012.10.002}
}

BibTeX:
@article{DeBlasi2012,
  author = {De Blasi, G. and Bouteyre, E. and Rollin, L.},
  title = {Consultation pluridisciplinaire d’aide à la reprise du travail après un cancer : des processus psychologiques en jeu dans la réinsertion professionnelle},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2012},
  volume = {73},
  number = {3},
  pages = {581--581},
  doi = {10.1016/j.admp.2012.03.686}
}

BibTeX:
@article{Gehanno2012f,
  author = {Gehanno, J.-F.},
  title = {L’information sur les dangers et les risques},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2012},
  volume = {73},
  number = {3},
  pages = {504--506},
  doi = {10.1016/j.admp.2012.02.032}
}

BibTeX:
@article{Griffon2012a,
  author = {Griffon, N et Devos, P et Gehanno, JF et Darmoni, SJ},
  title = {Existe-t-il une corrélation entre le score SIGAPS et les publications en français ?},
  month = {Septembre},
  journal = {La Presse Médicale},
  year = {2012},
  volume = {41},
  number = {9},
  pages = {e432–e435},
  doi = {10.1016/j.lpm.2012.03.015}
}

Abstract: Face au patient, le médecin n'a que très peu de temps disponible pour
consulter les informations médicales présentes dans le dossier patient,
les guides de bonnes pratiques ou les moteurs de recherche médicaux.
Une solution à  ce problème consiste à  proposer des outils graphiques
visuels permettant au médecin d'accéder très rapidement à  l'information,
comme le langage iconique Visualisation des connaissances médicales
(VCM) que nous avons proposé, il y a quelques années, pour représenter
à  l'aide d'icônes les principaux concepts médicaux : maladies, risques,
antécédents, traitements, examens... afin de faciliter la lecture
des monographies des médicaments. L'objectif du travail actuel est
d'étendre le langage VCM et de proposer de nouvelles applications
afin de résoudre les problèmes d'accès à  l'information rencontrés
par les médecins. Pour cela, nous avons d'abord analysé les difficultés
que les médecins généralistes et hospitaliers rencontre dans cette
tà¢che, puis nous en avons déduits les applications possibles et
les complémentations nécessaires à  apporter à  VCM. Nous avons
ensuite réalisé des prototypes de ces applications, qui sont en cours
d'évaluation.
BibTeX:
@article{Lamy,
  author = {Lamy, {J.-B.} and {Beuscart-Zéphir}, {M.-C.} and Boog, C. and Darmoni, S. and Favre, M. and Guigue, L. and Hamek, S. and Hassler, S. and Kerdelhué, G. and Leroy, N. and Mitouard, T. and Pereira, S. and Simon, C. and Venot, A. and Duclos, C.},
  title = {Langage iconique et interfaces interactives en médecine : application aux dossiers patients, guides de bonnes pratiques et moteurs de recherche médicaux},
  month = {April},
  journal = {{IRBM}},
  year = {2012},
  volume = {33},
  number = {2},
  pages = {129-136},
  url = {http://www.sciencedirect.com/science/article/pii/S1959031812000176},
  doi = {10.1016/j.irbm.2012.01.016}
}

Abstract: Cet article résume le travail de mise au point d'un outil d'analyse
du contenu textuel de dossiers hospitaliers afin d'y détecter des
indices permettant de suspecter des cas d'infections associées aux
soins. Des mécanismes de traitement de l'anonymat, de la terminologie,
des entités nommées, de la temporalité ont été mis au point, ainsi
qu'une caractérisation opérationnelle des scénarios à  risques. Les
résultats obtenus et les suites envisagées sont décrits dans cet
article.
BibTeX:
@article{Proux,
  author = {Proux, D. and Hagège, C. and Gicquel, Q. and Kergourlay, I. and Pereira, S. and Rondeau, G. and Darmoni, S. and Segond, F. and Metzger, {M.-H.}},
  title = {{ALADIN} : développement d'un outil sémantique d'analyse des documents textuels médicaux pour la détection d'infections associées aux soins},
  month = {April},
  journal = {{IRBM}},
  year = {2012},
  volume = {33},
  number = {2},
  pages = {137-142},
  url = {http://www.sciencedirect.com/science/article/pii/S195903181200019X},
  doi = {10.1016/j.irbm.2012.01.018}
}

BibTeX:
@article{Rollin2012b,
  author = {Rollin, L. and Boucher, L. and De Blasi, G. and Gehanno, J.-F.},
  title = {Apport d’une consultation pluridisciplinaire spécialisée dans le retour au travail après un cancer},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2012},
  volume = {73},
  number = {3},
  pages = {393--394},
  doi = {10.1016/j.admp.2012.03.174}
}

BibTeX:
@inproceedings{Gehanno2012b,
  author = {Gehanno, J.-F.},
  title = {Information sur les dangers et les risques},
  booktitle = {32eme congres National de Médecine et Santé au Travail},
  address = {Clermont-Ferrand},
  month = {June},
  year = {2012}
}

BibTeX:
@inproceedings{Gehanno2012c,
  author = {Gehanno, J.-F.},
  title = {Grossesse et travail},
  booktitle = {Salon de Gynécologie Obstétrique Pratique},
  address = {Paris},
  month = {March},
  year = {2012}
}

BibTeX:
@inproceedings{Braeckman2012,
  author = {Braeckman, L and Valcke, M and van Dik, F and Gehanno, JF and Pauncu, EA and Popescu, F and Hanna, M and Bulat, P},
  title = {{EMUTOM} : A European Module on Undergraduate Teaching in Occupational Medicine},
  booktitle = {30th International Congress on Occupational Health},
  month = {March},
  publisher = {Icoh},
  year = {2012},
  url = {http://icoh.confex.com/icoh/2012/webprogram/Paper8046.html}
}

BibTeX:
@inproceedings{Darmoni2012,
  author = {Darmoni, SJ and Grosjean, J and Merabti, T and Griffon, N and Dahamna, B and Dutoit, D},
  title = {Combining WordNet and Crosslingual multi-terminology health portal to access health information},
  booktitle = {6th International Global Wordnet Conference (GWC2012)},
  address = {Matsue, Japan},
  month = {January},
  year = {2012},
  pages = {94-99},
  url = {http://lang.cs.tut.ac.jp/gwc2012/index.html}
}

Abstract: Background: The Catalogue of French-speaking health resources available
on the Internet (French acronym: CISMeF) is a portal that gathers
French medical Web resources (n 90,000). Doc'UMVF is a semantic search
engine that allows searching in this database but filtering only
medical teaching materials (n=9,697). Currently, Doc'UMVF is based
on multi-terminology indexing, consequently, it works with the French
(n 500,000) and English terms (n 1,000,000) of the 32 terminologies
included in information system (IS). Using terminologies translated
in other language than only French and English would allow cross
lingual indexing and information retrieval of teaching material.
Objective: To make Doc'UMVF working in several languages. Method:
Some terminologies integrated in CISMeF IS have been translated in
numerous languages (e.g. International classification of disease,
tenth revision, is available in 11 languages, Medical Subject Heading
in 16 languages, etc). An enhanced version of the IS was necessary
to manage multiple translations and Doc'UMVF has to be adapted to
this new IS. Results: HeTOP is a portal that allows cross lingual
access to multiple terminologies. A semantic search engine based
on such tool could be useful in at least two use-cases. First, for
resources that exist in numerous languages, like European Medical
Agency (EMA) resources, there is only need for one indexing in one
language to allow their retrieval in many European languages. Second,
this provides a language independent tool: any teacher, whatever
his speaking language was, may index his own teaching material in
his own language and any student, whatever his speaking language
was, may find it. Conclusions: Doc'UMVF will soon work in the new
IS. Nevertheless, its natural language processing tools work only
in French, therefore its use should be reserved to advanced user
(those who know terminologies). There is not too much development
to achieve an operational language independent search engine dedicated
to teaching material.
BibTeX:
@inproceedings{Griffon2012d,
  author = {Griffon, N and Darmoni, SJ},
  title = {A cross lingual semantic search engine dedicated to medical teaching resources},
  booktitle = {MEI - Medical Education Informatics},
  address = {Thessaloniki, Greece},
  month = {April},
  year = {2012},
  url = {http://www.mei2012.org/content/cross-lingual-semantic-search-engine-dedicated-medical-teaching-resources}
}

BibTeX:
@inproceedings{Griffon2012b,
  author = {Griffon, N and Savoye-Collet, C and Massari, P and Daniel, C and Darmoni, SJ},
  title = {An interface terminology for medical imaging ordering purposes},
  booktitle = {AMIA Annual Symposium proceedings},
  address = {Chicago},
  month = {November},
  year = {2012},
  pages = {1237--1243},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540496/}
}

Abstract: The Health Terminology/Ontology Portal (HeTOP) was developed to provide
easy access to health terminologies and ontologie. The repository
is not only dedicated to professionals but is also a valuable teaching
tool. Currently, it provides access to thirty two health terminologies
and ontologies available mainly in French or in English, but also
in German, Italian, Chinese, etc. HeTOP can be used by both humans
and computers via Web services. To integrate new resources into HeTOP,
three steps are necessary: (1) designing a meta-model into which
each terminology (or ontology) can be integrated, (2) developing
a process to include terminologies into HeTOP, (3) building and integrating
existing and new inter &amp; intra-terminology semantic harmonization
into HeTOP. Currently, 600 unique machines use the MeSH version of
HeTOP every day and restricted terminologies/ontologies are used
for teaching purposes in several medical schools in France. The multilingual
version of HeTOP is available (URL: http://hetop.eu/) and provides
free access to ICD10 and FMA in ten languages. Conclusion: HeTOP
is a rich tool, useful for a wide range of applications and users,
especially in education and resource indexing but also in information
retrieval or performing audits in terminology management.
BibTeX:
@inproceedings{Grosjean2012a,
  author = {Grosjean, J and Merabti, T and Griffon, N and Dahamna, B and Darmoni, SJ},
  title = {Teaching medicine with a terminology/ontology portal},
  booktitle = {MIE},
  address = {Pisa, Italy},
  month = {August},
  journal = {Stud Health Technol Inform},
  year = {2012},
  volume = {180},
  pages = {949-53},
  doi = {10.3233/978-1-61499-101-4-949}
}

Abstract: Because of the ever-increasing amount of information in patients'
EHRs, healthcare professionals may face difficulties for making diagnoses
and/or therapeutic decisions. Moreover, patients may misunderstand
their health status. These medical practitioners need effective tools
to locate in real time relevant elements within the patients' EHR
and visualize them according to synthetic and intuitive presentation
models. The RAVEL project aims at achieving this goal by performing
a high profile industrial research and development program on the
EHR considering the following areas: (i) semantic indexing, (ii)
information retrieval, and (iii) data visualization. The RAVEL project
is expected to implement a generic, loosely coupled to data sources
prototype so that it can be transposed into different university
hospitals information systems.
BibTeX:
@inproceedings{Thiessard2012,
  author = {Thiessard, F and Mougin, F and Diallo, G and Jouhet, V and Cossin, S and Garcelon, N and Campillo, B and Jouini, W and Grosjean, J and Massari, P and Griffon, N and Dupuch, M and Tayalati, F and Dugas, E and Balvet, A and Grabar, N and Pereira, S and Frandji, B and Darmoni, SJ and Cuggia, M},
  title = {RAVEL: Retrieval And Visualization in ELectronic health records.},
  booktitle = {Quality of Life through Quality of Information - Proceedings of MIE2012},
  journal = {Stud Health Technol Inform},
  year = {2012},
  volume = {180},
  pages = {194--198},
  doi = {10.3233/978-1-61499-101-4-194}
}

BibTeX:
@inproceedings{Bouhaddou2011,
  author = {Bouhaddou, O and Darmoni, SJ and Thonnet, M},
  title = {Expérience avec le réseau national d'échange d'information médicale aux USA.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {287-296},
  url = {http://www.springerlink.com/content/r6318566m2w01705/},
  doi = {10.1007/978-2-8178-0285-5_25}
}

BibTeX:
@inproceedings{Dirieh2011,
  author = {Dirieh Dibad, AD and Soualmia, LF and Merabti, T and Grosjean, J and Sakji, S and Massari, P and Darmoni, SJ},
  title = {Un modèle de données adapté à la recherche d'information dans le dossier patient informatisé : étude, conception et évaluation.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {251-262},
  url = {http://www.springerlink.com/content/rx6402278w6m7863/},
  doi = {10.1007/978-2-8178-0285-5_22}
}

BibTeX:
@inproceedings{Griffon2012c,
  author = {Griffon, N and Massari, P and Joubert, M and Staccini, P and Darmoni, SJ},
  title = {Pertinence médicale des cooccurrences diagnostic-acte dans les résumés standardisés de sortie},
  booktitle = {PCSI (Patient Classification Systems International)},
  address = {Avignon, France},
  month = {October},
  year = {2012}
}

BibTeX:
@inproceedings{Joubert2011a,
  author = {Joubert, M and Vandenbussche, PY and Dahamna, B and Abdoune, H and Merabti, T and Pereira, S and Boyer, C and Staccini, P and Forget, JF and Delahousse, J and Darmoni, SJ and Fieschi, M},
  title = {InterSTIS : interopérabilité sémantique de terminologies de santé francophones.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  year = {2012},
  series = {Informatique et Santé},
  pages = {73-83},
  url = {www.springerlink.com/content/r7h673g11160384g/},
  doi = {10.1007/978-2-8178-0285-5_7}
}

BibTeX:
@inproceedings{Merabti2012b,
  author = {Merabti, T and Soualmia, LF and Grosjean, J and Joubert, M and Darmoni, SJ},
  title = {Méthodes d'alignement de terminologies médicales et leur intégration dans un portail},
  booktitle = {IC'2012 : Atelier IC pour l'intéropérabilité sémantique dans les applications en e-Santé},
  address = {Paris, France},
  year = {2012},
  url = {https://sites.google.com/site/icisante2012/programme}
}

BibTeX:
@inproceedings{Metzger2011,
  author = {Metzger, MH and Gicquel, Q and Kergourlay, I and Cluze, C and Grandbastien, B and Berrouane, Y and Tavolacci, MP and Segond, F and Pereira, S and Darmoni, SJ},
  title = {Codage standardisé de données médicales textuelles à l'aide d'un serveur multi-terminologique de santé : exemple d'application en épidémiologie hospitalière.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  year = {2012},
  series = {Informatique et Santé},
  pages = {109-120},
  doi = {10.1007/978-2-8178-0285-5_10}
}

BibTeX:
@inproceedings{Moalla2011,
  author = {Moalla, Z and Soualmia, LF and Prieur-Gaston, E and Darmoni, SJ},
  title = {Correction orthographique de requêtes : l'apport des distances de Levenshtein et Stoilos.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {3-12},
  url = {http://link.springer.com/chapter/10.1007%2F978-2-8178-0285-5_1},
  doi = {10.1007/978-2-8178-0285-5_1}
}

BibTeX:
@inproceedings{Pereira2011,
  author = {Pereira, S and Letord, C and Darmoni, SJ and Serrot, E},
  title = {Extraction des noms de médicaments dans les comptes rendus hospitaliers.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {145-153},
  doi = {10.1007/978-2-8178-0285-5_13}
}

BibTeX:
@inproceedings{Sakji2011,
  author = {Sakji, S and Elkin, P and Darmoni, SJ},
  title = {Évaluation de l'indexation des comptes rendus médicaux à l'aide d'un outil états-unien adapté pour le français.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {155-163},
  doi = {10.1007/978-2-8178-0285-5_14}
}

Abstract: The European Health Terminology/ Ontology Portal (EHTOP) is a repository
dedicated to European health professionals and students. Currently,
it provides access to terminologies and ontologies available in French
or in English, but also in German, Italian, Dutch, Spanish, Danish
and other 17 languages. EHTOP can be used by humans and by computers
via Web services. The main objective of EHTOP is to provide an access
to terminologies and ontologies, allowing dynamic browsing and navigation.
Methods: To integrate terminologies and ontologies into EHTOP, three
steps are necessary: (1) designing a meta-model into which each terminology
and ontology can be integrated, (2) developing a process to include
terminologies into EHTOP, (3) building and integrating existing and
new inter & intra-terminology semantic harmonization into EHTOP.
Results: EHTOP is available freely for the ICD-10 and the FMA (URL:
http://www.ehtop.eu/). The access to other terminologies/ontologies
(MeSH, SNOMED CT, WHO-ATC, ...) is restricted and available only
for the scientific community. A total of 32 terminologies are included
into EHTOP, with 980,000 concepts, 2,300,000 synonyms, 222,800 definitions
and 4,000,000 relations. Since January 2010, the bilingual version
of EHTOP is daily used by CISMeF librarians to index health resources
in the CISMeF catalogue in a multi-terminology mode. Currently, 600
unique machines are using this bilingual version, whereas 300 users
are already registered. Conclusion: EHTOP is a rich tool, useful
for a wide range of applications and users for educational purpose,
resources indexing, information retrieval or performing audits in
terminology management.
BibTeX:
@inproceedings{Grosjean2012,
  author = {Grosjean, J and Kerdelhué, G and Merabti, T and Darmoni, SJ},
  title = {The EHTOP: indexing Health resources in a multi-terminology/ontology and cross-lingual world},
  booktitle = {EAHIL 2012},
  year = {2012}
}

BibTeX:
@inproceedings{Coutant2012,
  author = {Coutant, S and Cabot, C and Tair, W and Lefebvre, A and Léonard, M and Prieur-Gaston, E and Campion, D and Lecroq, T and Dauchel, H},
  title = {EVA: Exome Variation Analyzer, A tool for filtering strategies in medical genomics},
  booktitle = {13e édition du colloque JOBIM (Journées Ouvertes en Biologie, Informatique et Mathématiques)},
  year = {2012},
  url = {http://jobim2012.inria.fr/jobim_actes_2012_online.pdf}
}

BibTeX:
@inproceedings{Diallo2012,
  author = {Diallo, G and Grabar, N and Thiessard, F and Garcelon, N and Grosjean, J and Dupuch, M and Pereira, S and Frandji, B and Darmoni, SJ and Cuggia, M},
  title = {Towards complex queries on data from complex patients},
  booktitle = {AMIA},
  address = {Chicago, Illinois},
  month = {November},
  year = {2012}
}

BibTeX:
@inproceedings{Gehanno2012e,
  author = {Gehanno, JF and Bulat, P and Smits, P and Dijk, E and Pauncu, E and Popescu, F and Jarreta, BM and Hanna, M and Chaudry, A and Braeckman, L},
  title = {Undergraduate occupational medicine teaching in european schools of medicine},
  booktitle = {30th International Congress on Occupational Health},
  address = {Cancun, Mexico},
  year = {2012}
}

BibTeX:
@inproceedings{Grosjean2012b,
  author = {Grosjean, J and Merabti, T and Griffon, N and Dahamna, B and Soualmia, LF and Darmoni, SJ},
  title = {Multi-terminology cross-lingual model to create the Health Terminology/Ontology Portal},
  booktitle = {AMIA},
  address = {Chicago},
  year = {2012}
}

BibTeX:
@inproceedings{Grosjean2012c,
  author = {Grosjean, J and Soualmia, LF and Merabti, T and Griffon, N and Dahamna, B and Darmoni, SJ},
  title = {Cross-lingual access to biomedical terminologies and ontologies},
  booktitle = {SWAT4LS (Semantic Web Applications and Tools for Life Sciences) Workshop},
  month = {November},
  year = {2012},
  note = {Poster},
  url = {http://ceur-ws.org/Vol-952/paper_17.pdf}
}

BibTeX:
@inproceedings{Merabti2012a,
  author = {Merabti, A and Soualmia, LF and Darmoni, SJ},
  title = {Extracting correspondences between terminologies for an easier access to biomedical information},
  booktitle = {Nettab2012},
  address = {Como, Italy},
  month = {November},
  year = {2012},
  pages = {127-129},
  url = {http://journal.embnet.org/index.php/embnetjournal/article/view/576}
}

BibTeX:
@inproceedings{Smits2012,
  author = {Smits, P and Braeckman, L and Dijk, E and Gehanno, JF and Pauncu, E and Popescu, F and Hanna, M and Bulat, P},
  title = {What every doctor should know about work and health : a needs analysis in six european countries},
  booktitle = {30th International Congress on Occupational Health},
  address = {Cancun, Mexico},
  year = {2012}
}

BibTeX:
@inbook{Duclos2013,
  author = {Duclos, C and Burgun, A and Lamy, JB and Landais, P and Rodrigues, JM and Soualmia, L and Zweigenbaum, P},
  title = {Informatique Médicale, e-Santé - Fondements et applications},
  publisher = {Springer},
  year = {2012},
  url = {http://www.springer.com/public+health/book/978-2-8178-0337-1}
}

BibTeX:
@incollection{Merabti2012,
  author = {Merabti, T and Soualmia, {LF} and Grosjean, J and Joubert, M and Darmoni, {SJ}},
  title = {Aligning Biomedical Terminologies in French: Towards Semantic Interoperability in Medical Applications},
  booktitle = {Medical Informatics},
  month = {March},
  publisher = {{InTech}},
  year = {2012},
  pages = {41--68},
  url = {http://www.intechopen.com/books/indexing/medical-informatics/methods-to-map-biomedical-terminologies-in-french-contribution-to-semantic-interoperability-between-}
}

BibTeX:
@inbook{Soualmia2012a,
  author = {Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {eHealth and Remote Monitoring},
  year = {2012},
  pages = {35-62},
  url = {http://www.intechopen.com/books/ehealth-and-remote-monitoring/supporting-e-health-information-seekers-from-simple-strategies-to-knowledge-based-methods},
  doi = {10.5772/50348}
}

BibTeX:
@inbook{Venot2012,
  author = {Venot, A and Charlet, J and Darmoni, SJ and Duclos, C and Dufour, JC and Soualmia, LF},
  title = {Informatique Médicale, e-Santé - Fondements et applications},
  publisher = {Springer},
  year = {2012},
  url = {http://www.springer.com/public+health/book/978-2-8178-0337-1}
}

BibTeX:
@phdthesis{DiriehDibad2012,
  author = {Dirieh Dibad, AD},
  title = {Recherche d'information multi-terminologique - Application au Dossier patient Informatisé},
  school = {University of Rouen, France and University of Djibouti},
  year = {2012},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2017/01/theseDIRIEHDIBADAumedDiouf_LITISCISMeF_VFF.pdf}
}

2011


Abstract: Outer-membrane-vesicle vaccines for meningococcal B outbreaks are complex and time consuming to develop. We studied the use of already available vaccine to control an outbreak caused by a genetically close strain. From 2006 to 2009, all individuals younger than 20 years living in the region of Normandy, France, in which an outbreak caused by a B:14:P1.7,16 strain occurred, were eligible to receive MenBvac, a Norwegian vaccine designed 20 years earlier against a strain sharing the same serosubtype (B:15:P1.7,16). The immunogenicity (in a randomly selected cohort of 400 children aged 1-5 years), safety, and epidemiological effect of the vaccination were assessed. 26,014 individuals were eligible to receive the vaccine. Shortage of vaccine production prompted start of the campaign in the highest incidence groups (1-5 years). 16,709 (64%) received a complete vaccination schedule of whom 13,589 (81%) received a 2+1 dose schedule (week 0, week 6, and month 8). At 6 weeks after the third dose, of 235 vaccinees for whom samples were available, 206 (88%) had a seroresponse, and 108 (56 %) of 193 had a seroresponse at 15 months. These results were similar to those described for tailor-made vaccines and their homologous strain. Only previously described adverse effects occurred. The incidence of B:14:P1.7,16 cases decreased significantly in the vaccine targeted population after the primary vaccination period (from 31·6 per 100,000 to 5·9 per 100,000; p=0·001). The ready-to-wear approach is reliable if epidemic and vaccine strains are genetically close. Other meningococcal B clonal outbreaks might benefit from this strategy; and previously described outer-membrane-vesicle vaccines can be effective against various strains. French Ministry of Health.
BibTeX:
@article{Caron2011,
  author = {Caron, François and du Châtelet, Isabelle Parent and Leroy, Jean-Philippe and Ruckly, Corinne and Blanchard, Myriam and Bohic, Nicole and Massy, Nathalie and Morer, Isabelle and Floret, Daniel and Delbos, Valérie and Hong, Eva and Révillion, Martin and Berthelot, Gilles and Lemée, Ludovic and Deghmane, Ala-Eddine and Bénichou, Jacques and Lévy-Bruhl, Daniel and Taha, Muhamed-Kheir},
  title = {From tailor-made to ready-to-wear meningococcal B vaccines: longitudinal study of a clonal meningococcal B outbreak.},
  month = {June},
  journal = {The Lancet. Infectious diseases},
  year = {2011},
  volume = {11},
  pages = {455--463},
  doi = {10.1016/S1473-3099(11)70027-5}
}

Abstract: BACKGROUND:General practitioners and medical specialists mainly rely
on one "general medical" journal to keep their medical knowledge
up to date. Nevertheless, it is not known if these journals display
the same overview of the medical knowledge in different specialties.
The aims of this study were to measure the relative weight of the
different specialties in the major journals of general medicine,
to evaluate the trends in these weights over a ten-year period and
to compare the journals.METHODS:The 14,091 articles published in
The Lancet, the NEJM, the JAMA and the BMJ in 1997, 2002 and 2007
were analyzed. The relative weight of the medical specialities was
determined by categorization of all the articles, using a categorization
algorithm which inferred the medical specialties relevant to each
article MEDLINE file from the MeSH terms used by the indexers of
the US National Library of Medicine to describe each article.RESULTS:The
14,091 articles included in our study were indexed by 22,155 major
MeSH terms, which were categorized into 81 different medical specialties.
Cardiology and Neurology were in the first 3 specialties in the 4
journals. Five and 15 specialties were systematically ranked in the
first 10 and first 20 in the four journals respectively. Among the
first 30 specialties, 23 were common to the four journals. For each
speciality, the trends over a 10-year period were different from
one journal to another, with no consistency and no obvious explanatory
factor.CONCLUSIONS:Overall, the representation of many specialties
in the four journals in general and internal medicine included in
this study may differ, probably due to different editorial policies.
Reading only one of these journals may provide a reliable but only
partial overview.
BibTeX:
@article{Gehanno2011,
  author = {Gehanno, JF and Ladner, J and Rollin, L and Dahamna, B and Darmoni, SJ},
  title = {How are the different specialties represented in the major journals in general medicine?},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2011},
  volume = {11},
  number = {1},
  pages = {3},
  doi = {10.1186/1472-6947-11-3}
}

Abstract: BACKGROUND:The identification of patients who pose an epidemic hazard
when they are admitted to a health facility plays a role in preventing
the risk of hospital acquired infection. An automated clinical decision
support system to detect suspected cases, based on the principle
of syndromic surveillance, is being developed at the University of
Lyon's Hopital de la Croix-Rousse. This tool will analyse structured
data and narrative reports from computerized emergency department
(ED) medical records. The first step consists of developing an
application (UrgIndex) which automatically extracts and encodes
information found in narrative reports. The purpose of the present
article is to describe and evaluate this natural language processing
system.METHODS:Narrative reports have to be pre-processed before
utilizing the French-language medical multi-terminology indexer (ECMT)
for standardized encoding. UrgIndex identifies and excludes syntagmas
containing a negation and replaces non-standard terms (abbreviations,
acronyms, spelling errors...). Then, the phrases are sent to the
ECMT through an Internet connection. The indexer's reply, based
on Extensible Markup Language, returns codes and literals corresponding
to the concepts found in phrases. UrgIndex filters codes corresponding
to suspected infections. Recall is defined as the number of relevant
processed medical concepts divided by the number of concepts evaluated
(coded manually by the medical epidemiologist). Precision is defined
as the number of relevant processed concepts divided by the number
of concepts proposed by UrgIndex. Recall and precision were assessed
for respiratory and cutaneous syndromes.RESULTS:Evaluation of 1,674
processed medical concepts contained in 100 ED medical records
(50 for respiratory syndromes and 50 for cutaneous syndromes) showed
an overall recall of 85.8% (95% CI: 84.1-87.3). Recall varied
from 84.5% for respiratory syndromes to 87.0% for cutaneous syndromes.
The most frequent cause of lack of processing was non-recognition
of the term by UrgIndex (9.7. Overall precision was 79.1% (95%
CI: 77.3-80.8). It varied from 81.4% for respiratory syndromes
to 77.0% for cutaneous syndromes.CONCLUSIONS:This study demonstrates
the feasibility of and interest in developing an automated method
for extracting and encoding medical concepts from ED narrative
reports, the first step required for the detection of potentially
infectious patients at epidemic risk.
BibTeX:
@article{gerbier_evaluation_2011,
  author = {Gerbier, Solweig and Yarovaya, Olga and Gicquel, Quentin and Millet, {Anne-Laure} and Smaldore, Veronique and Pagliaroli, Veronique and Darmoni, Stefan and Metzger, {Marie-Helene}},
  title = {Evaluation of natural language processing from emergency department computerized medical records for intra-hospital syndromic surveillance},
  journal = {{BMC} Medical Informatics and Decision Making},
  year = {2011},
  volume = {11},
  number = {1},
  pages = {50},
  url = {http://www.biomedcentral.com/1472-6947/11/50},
  doi = {10.1186/1472-6947-11-50}
}

BibTeX:
@article{Lefebvre2011,
  author = {Lefebvre, F and Merle, V and Savoye, G and Lemée, V and Chapuzet, C and Marini, H and Géhanno, J-F and Chefson-Girault, C and Gueit, I and Freymuth, F and Lerebours, E and Czernichow, P},
  title = {Nosocomial transmission of measles: do we need extra precautions to avoid it?},
  month = {October},
  journal = {The Journal of hospital infection},
  year = {2011},
  volume = {79},
  number = {2},
  pages = {185--187},
  doi = {10.1016/j.jhin.2011.05.025}
}

Abstract: BACKGROUND:The Foundational Model of Anatomy (FMA) is the reference
ontology regarding human anatomy. FMA vocabulary was integrated into
the Health Multi Terminological Portal (HMTP) developed by CISMeF
based on the CISMeF Information System which also includes 26 other
terminologies and controlled vocabularies, mainly in French. However,
FMA is primarily in English. In this context, the translation of
FMA English terms into French could also be useful for searching
and indexing French anatomy resources. Various studies have investigated
automatic methods to assist the translation of medical terminologies
or create multilingual medical vocabularies. The goal of this study
was to facilitate the translation of FMA vocabulary into French.METHODS:We
compare two types of approaches to translate the FMA terms into French.
The rst one is UMLS-based on the conceptual information of the UMLS
metathesaurus. The second method is lexically-based on several Natural
Language Processing (NLP) tools.RESULTS:The UMLS-based approach produced
a translation of 3,661 FMA terms into French whereas the lexical
approach produced a translation of 3,129 FMA terms into French. A
qualitative evaluation was made on 100 FMA terms translated by each
method. For the UMLS-based approach, among the 100 translations,
52% were manually rated as "very good" and only 7% translations as
"bad". For the lexical approach, among the 100 translations, 47%
were rated as "very good" and 20% translations as "bad".CONCLUSIONS:Overall,
a low rate of translations were demonstrated by the two methods.
The two approaches permitted us to semi-automatically translate 3,776
FMA terms from English into French, this was to added to the existing
10,844 French FMA terms in the HMTP (4,436 FMA French terms and 6,408
FMA terms manually translated).
BibTeX:
@article{Merabti2011b,
  author = {Merabti, Tayeb and Soualmia, Lina and Grosjean, Julien and Palombi, Olivier and Muller, Jean-Michel and Darmoni, SJ},
  title = {Translating the Foundational Model of Anatomy into French using knowledge-based and lexical methods},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2011},
  volume = {11},
  number = {1},
  pages = {65},
  url = {http://www.biomedcentral.com/1472-6947/11/65},
  doi = {10.1186/1472-6947-11-65}
}

Abstract: Contexte La prolifération des documents liés à la santé des individus
pose aujourd'hui le problème de leur indexation et de leur recherche
dans de vastes bases de données.Objectif Si l'on veut indexer d'autres
types de documents que des documents pédagogiques ou de la documentation
scientifique, il faut être capable d'indexer des comptes rendus cliniques,
des résultats d'examens, des courriers, etc.Matériel et méthode
Des terminologies à visées différentes sont alors utilisées : la
SNOMED pour le codage d'informations cliniques, la CIM-10 et
la CCAM pour le codage épidémiologique et médico-économique, la
CISP utilisée par les médecins généralistes, etc. Le but d'InterSTIS
était de les unifier et de les rendre interopérables au sein d'un
« serveur terminologique multi-sources ». InterSTIS exploite des
sources de connaissance de UMLS issues de la National Library of
Medicine des États-Unis pour rendre ces terminologies interopérables.Résultat
Un serveur terminologique multi-sources opérationnel apte à délivrer
des services à des utilisateurs et à des applications. InterSTIS
a commencé en janvier 2008 et s'est fini en décembre 2010.
BibTeX:
@article{Joubert2011,
  author = {Joubert, M and le consortium du projet InterSTIS},
  title = {Interopérabilité sémantique de terminologies de santé francophones},
  journal = {{IRBM}},
  year = {2011},
  volume = {32},
  number = {2},
  pages = {80-82},
  url = {http://www.sciencedirect.com/science/article/B94S6-5295K6S-6/2/2a900945a16a740449bd22d6bb379b7a},
  doi = {10.1016/j.irbm.2011.01.030}
}

Abstract: Depuis 2007, 44 chefs de clinique de médecine générale (CCA-MG) ont
été nommés au sein des facultés de médecine françaises. L’étude descriptive
réalisée en 2008 et 2009 par l’association des chefs de clinique
montrait que leur activité était très hétérogène. Malgré la montée
en charge progressive de la filière universitaire (avec en moyenne
15 nouveaux chefs de clinique par an), une insuffisance de visibilité
et de lisibilité sur l’activité des CCA-MG résultait de l’absence
de texte réglementaire encadrant cette activité.
BibTeX:
@article{Schuers2011,
  author = {Schuers, M.},
  title = {Quel modèle pour le clinicat de médecine générale ?},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2011},
  number = {95 suppl 1},
  pages = {38--9}
}

BibTeX:
@inproceedings{Gehanno2011c,
  author = {Gehanno, JF},
  title = {Des indicateurs pour changer les pratiques ou des pratiques pour changer des indicateurs ?},
  booktitle = {31èmes Journées Nationales de santé au travail dans le BTP},
  address = {Versailles, France},
  month = {Mai},
  year = {2011}
}

BibTeX:
@inproceedings{Gehanno2012d,
  author = {Gehanno, JF},
  title = {Accès à la connaissance par l'utilisation des bases de données via Internet},
  booktitle = {26èmes Journées Internationales Méditerranéennes de Médecine du Travail},
  address = {Rennes, France},
  month = {Mai},
  year = {2011}
}

Abstract: Background: the Core Subset of SNOMED CT is part of the UMLS-Core
Project dedicated to study problem list vocabularies. SNOMED CT is
not yet translated into French. Objective: to propose an automated
method to assist the translation of the CORE Subset of SNOMED CT
into French. Material: the 2009 AA versions of the CORE Subset of
SNOMED CT and UMLS; use of four French-language terminologies integrated
into the UMLS Metathesaurus: SNOMED International, ICD10, MedDRA,
and MeSH. Method: an exact mapping completed by a close mapping between
preferred terms of the CORE Subset of SNOMED CT and those of the
four terminologies. Results: 89% of the preferred terms of the CORE
Subset of SNOMED CT are mapped with at least one preferred term in
one of the four terminologies. Discussion: if needed, synonymous
terms could be added by the means of synonyms in the terminologies;
the proposed method is independent from French and could be applied
to other natural languages.
BibTeX:
@inproceedings{Abdoune2011,
  author = {Abdoune, H and Merabti, T and Darmoni SJ and Joubert, M},
  title = {Assisting the translation of the CORE Subset of SNOMED CT into French},
  booktitle = {User Centred Networked Health Care - Proceedings of MIE 2011},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {169},
  pages = {819-823},
  doi = {10.3233/978-1-60750-806-9-819}
}

BibTeX:
@inproceedings{Ammenwerth2011,
  author = {Ammenwerth, E and Hackl, WO and Massari, P and Darmoni, SJ},
  title = {Validation of Completeness, Correctness, Relevance and Understandability of the PSIP CDSS for Medication Safety},
  booktitle = {Patient Safety Informatics - Adverse Drug Events, Human Factors and IT Tools for Patient Medication Safety},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {166},
  pages = {254-259},
  note = {PSIP},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=19731},
  doi = {10.3233/978-1-60750-740-6-254}
}

BibTeX:
@inproceedings{Golbreich2011,
  author = {Golbreich, C and Grosjean, J and Darmoni, SJ},
  title = {The FMA in OWL 2},
  booktitle = {AIME},
  publisher = {Springer-Verlag},
  year = {2011},
  volume = {6747},
  pages = {204-214},
  url = {http://www.springer.com/computer/ai/book/978-3-642-22217-7},
  doi = {10.1007/978-3-642-22218-4_25}
}

Abstract: Background: Following a recent change in the indexing policy for French
quality controlled health gateway CISMeF, multiple terminologies
are now being used for indexing in addition to MeSH®. Objective:
To evaluate precision and recall of super-concepts for information
retrieval in a multi-terminology paradigm compared to MeSH-only.
Methods: We evaluate the relevance of resources retrieved by multi-terminology
super-concepts and MeSH-only super-concepts queries. Results: Recall
was 8-14% higher for multi-terminology super-concepts compared to
MeSH only super-concepts. Precision decreased from 0.66 for MeSH
only super-concepts to 0.61 for multi-terminology super-concepts.
Retrieval performance was found to vary significantly depending on
the super-concepts (p<10-4) and indexing methods (manual vs automatic;
p<0.004). Conclusion: A multi-terminology paradigm contributes to
increase recall but lowers precision. Automated tools for indexing
are not accurate enough to allow a very precise information retrieval.
BibTeX:
@inproceedings{Griffon2011,
  author = {Griffon, N and Soualmia LF and Névéol, A and Massari P and Thirion B and Dahamna, B and Darmoni, SJ},
  title = {Evaluation of Multi-Terminology Super-Concepts for Information Retrieval},
  booktitle = {User Centred Networked Health Care - Proceedings of MIE 2011},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {169},
  pages = {492-496},
  doi = {10.3233/978-1-60750-806-9-492}
}

BibTeX:
@inproceedings{Grosjean2011a,
  author = {Grosjean, J and Merabti, T and Dahamna, B and Kergourlay, I and Thirion B and Soualmia LF and Darmoni, SJ},
  title = {Health Multi-Terminology Portal: a semantics added-value for patient safety},
  booktitle = {Patient Safety Informatics - Adverse Drug Events, Human Factors and IT Tools for Patient Medication Safety},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {166},
  pages = {129-138},
  note = {PSIP},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=19716},
  doi = {10.3233/978-1-60750-740-6-129}
}

BibTeX:
@inproceedings{Grosjean2011b,
  author = {Grosjean, J and Merabti, T and Griffon, N and Dahamna, B and Darmoni SJ},
  title = {Multiterminology cross-lingual model to create the European Health Terminology/Ontology Portal},
  booktitle = {Short papers of the 9th International Conference on Terminology and Artificial Intelligence, TIA},
  address = {Paris},
  month = {November},
  year = {2011},
  pages = {119-122},
  url = {http://tia2011.crim.fr/Proceedings/pdf/TIA20.pdf}
}

Abstract: This paper describes the first steps of development of a rule-based
system that automatically processes medical records in order to discover
possible cases of hospital acquired infections (HAI). The system
takes as input a set of patient records in electronic format and
gives as output, for each document, information regarding HAI. In
order to achieve this goal, a temporal processing together with a
deep syntactic and semantic analysis of the patient records is performed.
Medical knowledge used by the rules is derived from a set of documents
that have been annotated by medical doctors. After a brief description
of the context of this work, we present the general architecture
of our document processing chain and explain how we perform our temporal
and linguistic analysis. Finally, we report our preliminary results
and we lay out the next steps of the project.
BibTeX:
@inproceedings{Hagege2010,
  author = {Hagège, C and Marchal, P and Gicquel, Q and Darmoni, SJ and Pereira, S and Metzger, MH},
  title = {Linguistic and Temporal Processing for Discovering Hospital Acquired Infection from Patient Records},
  booktitle = {Knowledge Representation for Health-Care},
  address = {Lisbon, Portugal},
  month = {August},
  publisher = {Springer Berlin / Heidelberg},
  year = {2011},
  series = {Lecture Notes in Computer Science},
  volume = {6512},
  pages = {70--84},
  note = {The 2nd International Workshop on Knowledge Representation for Health Care (KR4HC-2010) - Workshop ECAI 2010},
  doi = {10.1007/978-3-642-18050-7_6}
}

BibTeX:
@inproceedings{Merabti2011a,
  author = {Merabti, T and Abdoune, H and Letord, C and Sakji, S and Joubert, M and Darmoni SJ},
  title = {Mapping the ATC classification to the UMLS Metathesaurus: some pragmatic applications},
  booktitle = {Patient Safety Informatics - Adverse Drug Events, Human Factors and IT Tools for Patient Medication Safety},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {166},
  pages = {206-213},
  note = {PSIP},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=19725},
  doi = {10.3233/978-1-60750-740-6-206}
}

BibTeX:
@inproceedings{Moalla2011a,
  author = {Moalla, Z and Soualmia, LF and Prieur-Gaston, E and Lecroq, T and Darmoni, SJ},
  title = {Spell-checking queries by combining Levenshtein and Stoilos distances},
  booktitle = {Proccedings of NETTAB'11(Network Tools and Applications in Biology)},
  address = {Pavia, Italy},
  month = {October},
  year = {2011},
  url = {http://www-igm.univ-mlv.fr/~lecroq/articles/nettab2011-dis.pdf}
}

Abstract: This paper describes the latest developments in the design of a tool
to monitor Patient Discharge Summaries to detected pieces of evidences
related to Hospital Acquired Infections. Anonymization, Named Entity
detection, Temporal Expressions analysis and Causality detection
methods have been developed and evaluated. They are embedded in a
tool designed to work in a Hospital Information Workflow.
BibTeX:
@inproceedings{Proux2011,
  author = {Proux, D and Hagège, C and Gicquel, Q and Pereira, S and Darmoni, SJ and Segond, F and Metzger, MH},
  title = {Architecture and Systems for Monitoring Hospital Acquired Infections inside Hospital Information Workflows},
  booktitle = {Proceedings of the Workshop on Biomedical Natural Language Processing},
  address = {Hissar, Bulgaria},
  publisher = {Association for Computational Linguistics},
  year = {2011},
  pages = {43-48},
  url = {http://aclweb.org/anthology/W11-4207}
}

BibTeX:
@inproceedings{LF2011,
  author = {Soualmia, LF and Griffon, N and Grosjean, J and Darmoni, SJ},
  title = {Improving Information Retrieval by Meta-Modelling Medical Terminologies},
  booktitle = {13th conference on Artificial Intelligence in MEdicine (AIME)},
  publisher = {Springer, Heidelberg},
  year = {2011},
  series = {Lectures Notes in ArtificiaI Intelligence},
  pages = {pp. 215--219},
  doi = {10.1007/978-3-642-22218-4_26}
}

BibTeX:
@inproceedings{Gicquel2011,
  author = {Gicquel, Q and Proux, D and Marchal, P and Hagège, C and Berrouane, Y and Darmoni, SJ and Pereira, S and Segond, F and Metzger, MH},
  title = {Evaluation d'un outil d'aide à l'anonymisation des documents médicaux basé sur le traitement automatique du langage naturel.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2011},
  series = {Informatique et Santé},
  pages = {165-176},
  url = {http://www.springerlink.com/content/vr3338x017671826/},
  doi = {10.1007/978-2-8178-0285-5_15}
}

BibTeX:
@inproceedings{Hagege2011a,
  author = {Hagège, C and Proux, D and Gicquel, Q and Darmoni, SJ and Pereira, S and Segond, F and Metzger, MH},
  title = {Développement d'un système de détection des infections associées aux soins à partir de l'analyse de comptes-rendus d'hospitalisation},
  booktitle = {Traitement Automatique des Langues Naturelles (TALN)},
  address = {Montpellier, France},
  month = {Juin-Juillet},
  year = {2011},
  url = {http://www.lirmm.fr/~lopez/RECITAL/PDF_court/Hagege_taln11_submission_136.pdf}
}

BibTeX:
@inproceedings{Merabti2011,
  author = {Merabti, T and Grosjean, J and Abdoune, H and Joubert, M and Darmoni SJ},
  title = {Automatic methods for mapping Biomedical terminologies in a Health Multi-Terminology Portal},
  booktitle = {EGC 2011 : atelier Extraction de Connaissances et Santé},
  year = {2011}
}

BibTeX:
@inproceedings{Gehanno2011a,
  author = {Gehanno, J.-F.},
  title = {Epidémiologie des maladies infectieuses chez les professionnels de santé},
  booktitle = {{XXIIème} congrès de la Société Française {d'Hygiène} Hospitalière},
  address = {Lyon},
  month = {June},
  year = {2011}
}

BibTeX:
@inproceedings{Gehanno2011b,
  author = {Gehanno, J.-F.},
  title = {Les principaux risques infectieux et leurs modes de transmission},
  booktitle = {{JISSSP}},
  address = {Aix en Provence},
  month = {June},
  year = {2011}
}

BibTeX:
@inproceedings{Grosjean2011,
  author = {Grosjean, J and Merabti, T and Darmoni SJ},
  title = {Health Multi-Terminology Portal},
  booktitle = {RITS Recherche en Imagerie et Technologie pour la Santé},
  address = {Rennes},
  year = {2011}
}

BibTeX:
@inproceedings{Berrouane2011,
  author = {Berrouane, Y and Hagège, C and Gicquel, Q and Kergoulay, I and Pereira, S and Proux, D and Darmoni SJ and Segond, F and Metzger, MH},
  title = {Preliminary evaluation of an automated detection tool for healthcare-associated infections, based on screening natural language medical reports},
  booktitle = {ECCMID European Congress of Clinical Microbiology and Infectious Diseases},
  year = {2011},
  url = {http://www.eccmid-icc2011.org/}
}

BibTeX:
@inproceedings{Bousquet2011,
  author = {Bousquet, C and Souvignet, J and Merabti, T and Sadou, E and Trombert, B and Rodrigues, JM},
  title = {Method for mapping the French CCAM terminology to the UMLS metathesaurus},
  booktitle = {MIE},
  journal = {#Stud##Health##Technol##Inform#},
  year = {2011},
  volume = {180},
  pages = {164-68},
  doi = {10.3233/978-1-61499-101-4-164}
}

BibTeX:
@inproceedings{Dirieh2011a,
  author = {Dirieh Dibad, AD et al.},
  title = {Information Retrieval in Electronic Health Record: a feasibility study},
  booktitle = {MIE},
  year = {2011},
  url = {http://person.hst.aau.dk/ska/mie2011/CD/MIE_2011_Content/Posters/026_or_submission_136_3_am_sm_ok.pdf}
}

BibTeX:
@inproceedings{Kerdelhue2011,
  author = {Kerdelhue, G and Gehanno, JF},
  title = {Tools and organization of a current awareness service},
  booktitle = {Eahil},
  year = {2011},
  note = {One of 10 best posters.}
}

BibTeX:
@inbook{Soualmia2011,
  author = {Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {Information Extraction from Internet},
  publisher = {CreateSpace},
  year = {2011},
  pages = {89-108},
  url = {http://www.iconceptpress.com/www/site/download.paper.php?paperID=100619153747}
}

BibTeX:
@techreport{Golbreich2011a,
  author = {Golbreich, C and Grosjean, J and Darmoni, SJ},
  title = {The Foundational Model of Anatomy in the Health Multi-Terminology Portal},
  year = {2011},
  note = {Technical report}
}

Abstract: Le Cismef intègre désormais plusieurs terminologies au service de
l'indexation et de l'interrogation de ses ressources. Un chantier
mené à bien grâce à  l'emploi de standards du web sémantique tels
que RDF et Owl.
BibTeX:
@article{Merabti2011c,
  author = {Merabti, Tayeb},
  title = {Le CISMeF agrège ses terminologies pour une meilleure recherche dans ses fonds},
  journal = {Documentaliste - Sciences de l'information},
  year = {2011},
  number = {4},
  url = {http://www.adbs.fr/web-semantique-web-de-donnees-pole-2-le-cismef-agrege-ses-terminologies-pour-une-meilleure-recherche-dans-ses-fonds-112553.htm?RH=REVUE}
}

2010


Abstract: OBJECTIVE: Most occupational health physicians access electronic databases
to obtain reliable medical information. Although it is demonstrated
that the use of Medline alone does not ensure comprehensiveness,
many experts rely solely on this database. Our study aimed to discover
to what extent the physician who limits his/her search to Medline
misses studies of high quality. METHODS: We constructed a "gold standard"
database of high-quality intervention studies gathering all the references
included in the systematic reviews of the Cochrane Library and indexed
under the topic "occupational health field". We then searched all
these references, one by one, in Medline. RESULTS: Overall, 88.8%
[95% confidence interval (95% CI) 86.1-91.5] of the high quality
studies included in our gold standard database were indexed in Medline.
References included in reviews on psychiatric or psychological topics
were significantly less often indexed in Medline [81.7% (95% CI
75.9-88.5)] than references included in reviews on other topics [92.2%
(95% CI 89.5-95.0)] (P=0.001). CONCLUSION: The recall ratio of Medline
for high-quality intervention studies is close to 90%. For occupational
health practitioners who aim to find reliable answers to their daily
practice questions, searching Medline only is more cost-effective
than previously thought.
BibTeX:
@article{Rollin2010,
  author = {Laetitia Rollin and Stefan Darmoni and Jean-François Caillard and Jean-François Gehanno},
  title = {Searching for high-quality articles about intervention studies in occupational health - what is really missed when using only the Medline database?},
  month = {Aug},
  journal = {Scand J Work Environ Health},
  school = {Service de Médecine du Travail, Rouen University Hospital, 1 rue de Germont, 76000 Rouen, France. -laetitia.rollin@chu-rouen.fr.},
  year = {2010},
  volume = {36},
  number = {6},
  pages = {484-487},
  url = {http://www.sjweh.fi/show_abstract.php?abstract_id=3082},
  doi = {10.5271/sjweh.3082}
}

Abstract: Contexte. Les infections urinaires chez l’enfant font l’objet d’une
grande diversité de prises en charge. En 2007, dans le but d’homogénéiser
les pratiques, l’AFSSAPS a publié des recommandations de bonnepratique
sur ce sujet. La présente étude avait pour objectif d’analyser l’opinion
des médecins généralistes sur le contenu et la présentation de ces
recommandations.Méthode. Étude qualitative conduite à l’aide d’entretiens
semi-dirigés auprès de 12 médecins généralistes de Seine-Maritime.Résultats.
Dans la recommandation, les médecins ont relevé 12 points ne répondant
pas à leurs préoccupations pratiques. Le manque de clarté du message
et l’absence des niveaux de preuves dans le résumé ont porté préjudice
à l’accueil de la recommandation. Les opinions des médecins étaient
fortement influencées par leur expérience personnelle et leurs résistances
aux changements.Conclusion. Selon les médecins généralistes, ces
recommandations ne répondent pas complètement àleurs besoins. Pour
eux, la présentation et la rigueur scientifique du résumé ne sont
pas satisfaisantes. Ces facteurs, tout comme l’anticipation du comportement
des lecteurs, devraient être davantage pris encompte dans la construction
des recommandations, comme le préconisent les guides méthodologiques.
BibTeX:
@article{Barbeau2010,
  author = {Barbeau, L and Renoux, C. and Barbeau, H and Schuers, M. and Thueux, MT},
  title = {Recommandations {AFSSAPS} pour la prise en charge des infections urinaires de l'enfant},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2010},
  number = {91},
  pages = {36--40}
}

Abstract: Background: Orphanet aims to provide rare disease information to healthcare
professionals, patients, and their relatives. Objective: The objective
of this work is to evaluate two methodologies (UMLS and manual Orphanet-ICD-10
link-based mapping & String Based matching) used to map Orphanet
thesaurus to the MeSH thesaurus. Results: On a corpus of 375 mappings,
the string based matching provides significantly better results than
the UMLS and manual Orphanet-ICD-10 link-based mapping. Conclusion:
String based matching could be applied to any biomedical terminology
in French not yet included into UMLS.
BibTeX:
@article{Darmoni2010,
  author = {Darmoni, SJ and Merabti, T and Joubert, M and Lecroq, T and Rath, A},
  title = {Mapping biomedical terminologies using natural language processing tools and UMLS: mapping the Orphanet thesaurus to the MeSH},
  journal = {Ingénierie et Recherche Biomédicale / BioMedical Engineering and Research},
  year = {2010},
  volume = {31},
  number = {4},
  pages = {221-225},
  doi = {10.1016/j.irbm.2010.04.003}
}

BibTeX:
@article{Goulle2010a,
  author = {Goullé, Jean-Pierre and Gehanno, Jean-François and Mahieu, Loic and Saunier, Florence and Saussereau, Élodie and Guerbet, Michel and Lacroix, Christian},
  title = {Intérêt de la mesure des isotopes du plomb dans un cas d'intoxication familiale par un plat à tajine},
  month = {October},
  journal = {Annales de Toxicologie Analytique},
  year = {2010},
  volume = {22},
  number = {3},
  pages = {153--157},
  url = {http://www.ata-journal.org/index.php?option=com_article&access=standard&Itemid=129&url=/articles/ata/abs/2010/03/ata09063/ata09063.html},
  doi = {10.1051/ata/2010020}
}

Abstract: Plusieurs affections rhumatologiques peuvent être déclarées et reconnues
en maladies professionnelles (MP). Les troubles musculosquelettiques
(TMS) des membres occupent la première place et représentent plus
des deux tiers des MP indemnisées en France. Les TMS du rachis lombaire
sont également fréquents et potentiellement liés au travail, cependant
seules les radiculalgies en lien avec une hernie discale font l'objet
d'un tableau de MP, la lombalgie commune étant, quant à elle, souvent
déclarée en accident de travail. Plusieurs facteurs, souvent associés
d'ailleurs, contribuent à la survenue des TMS : ils sont de type
biomécaniques, psychosociaux et personnels. Le dépistage précoce
des atteintes (représentées au départ par de simples douleurs) permettant
le déclenchement d'une action visant à réduire les facteurs de risque
professionnels est essentiel afin de prévenir une aggravation ultérieure,
avec un retentissement potentiellement grave (symptômes invalidants
avec réduction de la capacité de travail et éventuellement désinsertion
professionnelle). La collaboration du médecin du travail, en charge
de l'action en entreprise, et du médecin traitant (généraliste, rhumatologue,
orthopédiste) est à cet égard indispensable. Enfin, d'autres affections
rhumatologiques font l'objet de tableaux de MP, seuls les tableaux
concernant les vibrations et les ports de charges en position agenouillée
représentent actuellement un nombre significatif de déclaration de
MP.
BibTeX:
@article{Rollin2010a,
  author = {Rollin, L. and Caillard, J.-F.},
  title = {Affections rhumatologiques reconnues au titre des maladies professionnelles},
  journal = {EMC - Traité de médecine AKOS},
  year = {2010},
  volume = {5},
  number = {3},
  pages = {1--5}
}

Abstract: Recruter et inclure des patients est la première des difficultés de
nombreux projets de recherche. La recherche en soins primaires n’échappe
pas à cette réalité, et les exemples sont nombreux où les difficultés
d’inclusion ont conduit à l’arrêt prématuré du projet. La loi de
Lasagna, selon laquelle les chercheurs et les investigateurs surestiment
systématiquement le nombre de patients pouvant être inclus dans une
étude, rend compte de cette situation.
BibTeX:
@article{Schuers2010,
  author = {Schuers, M.},
  title = {Le défi du recrutement des enfants pour la recherche en médecine générale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2010},
  number = {94 suppl 4},
  pages = {102--3}
}

BibTeX:
@inproceedings{Gehanno2010,
  author = {Gehanno, JF},
  title = {Référentiels et évaluation des pratiques professionnelles},
  booktitle = {47èmes journées Santé-Travail du CISME},
  address = {Paris, France},
  month = {Octobre},
  year = {2010}
}

BibTeX:
@inproceedings{Deleger2010,
  author = {Déleger, L and Merabti, T and Lecroq, T and Joubert, M and Zweigenbaum, P and Darmoni, SJ},
  title = {A Twofold Strategy for Translating a Medical Terminology into French},
  booktitle = {AMIA},
  year = {2010},
  pages = {152-156},
  note = {Distinguished paper award}
}

BibTeX:
@inproceedings{Lamy2010,
  author = {Lamy, JB and Duclos, C and Hamek, S and Beuscart, MC and Kerdelhué, G and Darmoni, SJ and Favre, M and Falcoff, H and Simon, C and Pereira, S and Serrot, E and Mitouard, T and Hardouin, E and Kergosien, Y and Venot, A},
  title = {Towards iconic language for patient records, drug monographs, guidelines and medical search engines},
  booktitle = {MEDINFO 2010 - Proceedings of the 13th World Congress on Medical Informatics},
  address = {Cape Town, South Africa},
  journal = {Stud Health Technol Inform},
  year = {2010},
  volume = {160},
  number = {pt 1},
  pages = {156--160}
}

Abstract: Background: CCAM is a French terminology for coding clinical procedures.
CCAM is a multi-hierarchical structured classification for procedures
used in France for reimbursement in health care, which is external
to UMLS. Objective: The objective of this work is to describe a French
lexical approach allowing mapping CCAM procedures to the UMLS Metathesaurus
to achieve interoperability to multiple international terminologies.
This approach used a preliminary step intended to take only the significant
characters used to code CCAM corresponding to anatomical and actions
axes. Results: According to the 7,926 CCAM codes used in this study,
5,212 possible matches (exact matching, single to multiple matching,
partial matching) are found using the French CCAM to UMLS based mapping,
65% of the corresponding anatomical terms in the CCAM code are mapped
to at least one UMLS Concept and 37% of the corresponding action
terms in the CCAM code are mapped to at least one UMLS Concept. For
all the exact matches found (n=200), 91% were rated by a human expert
as narrower than the mapped UMLS Concepts, while only 3% were irrelevant.
BibTeX:
@inproceedings{Merabti2010,
  author = {Merabti, Tayeb and Massari,Philipe and Joubert, Michel and Sadou,Eric and Lecroq,Thierry and Abdoune, Hocine and Rodrigues,Jean-Marie and Darmoni, Stéfan J},
  title = {An Automated Approach to map a French terminology to UMLS.},
  booktitle = {MEDINFO 2010 - Proceedings of the 13th World Congress on Medical Informatics},
  address = {Cape Town, South Africa},
  journal = {Stud Health Technol Inform},
  school = {TIBS, LITIS EA 4108, Institute of Biomedical Research, France.},
  year = {2010},
  volume = {160},
  number = {pt 1},
  pages = {1040--1044},
  url = {http://hal.archives-ouvertes.fr/hal-00563123/en/}
}

BibTeX:
@inproceedings{Merlin2010,
  author = {Merlin, B and Chazard, E and Pereira, S and Serrot, E and Sakji, S and Beuscart, R and Darmoni, SJ},
  title = {Can F-MTI semantic-mined drug codes be used for Adverse Drug Events detection when no CPOE is available?},
  booktitle = {MEDINFO 2010 - Proceedings of the 13th World Congress on Medical Informatics},
  address = {Cape Town, South Africa},
  journal = {Stud Health Technol Inform},
  year = {2010},
  volume = {160},
  number = {pt 1},
  pages = {1025-1029}
}

BibTeX:
@inproceedings{Proux2010,
  author = {Proux, D and Marchal, P and Segond, F and Kergourlay, I and Pereira, S and Gicquel, Q and Darmoni, SJ and Metzger, MH},
  title = {Improving Hospital Document workflow with a Risk Patterns Detection tool to detect potential Hospital Acquired Infections},
  booktitle = {Biomedical Information Extraction, RANLP conference},
  year = {2010},
  note = {ALADIN.},
  url = {http://www.lml.bas.bg/ranlp2009/biomedicalIE/}
}

BibTeX:
@inproceedings{Sakji2010,
  author = {Sakji, S and Gicquel, Q and Pereira, S and Kergoulay, I and Proux, D and Darmoni SJ and Metzger, MH},
  title = {Evaluation of a French Medical Multi-Terminology Indexer for the Manual Annotation of Natural Language Medical Reports of Healthcare-Associated Infections},
  booktitle = {MEDINFO 2010 - Proceedings of the 13th World Congress on Medical Informatics},
  address = {Cape Town, South Africa},
  journal = {Stud Health Technol Inform},
  year = {2010},
  volume = {160},
  number = {Pt 1},
  pages = {252--256}
}

Abstract: The lack of interoperability between repositories of heterogeneous
and geographically widespread data is an obstacle to the diffusion,
sharing and reutilization of those data. We present the development
of an open repositories network taking into account both the syntactic
and semantic interoperability of the different repositories and based
on international standards in this field. The network is used by
the medical community in France for the diffusion and sharing of
digital teaching resources. The syntactic interoperability of the
repositories is managed using the OAI-PMH protocol for the exchange
of metadata describing the resources. Semantic interoperability is
based, on one hand, on the LOM standard for the description of resources
and on MESH for the indexing of the latter and, on the other hand,
on semantic interoperability management designed to optimize compliance
with standards and the quality of the metadata.
BibTeX:
@inproceedings{Soula2010,
  author = {Soula, G and Darmoni, SJ and Le Beux, P and Renard, JM and Dahamna, B and Fieschi, M},
  title = {An open repositories network development for medical teaching resources.},
  booktitle = {MEDINFO 2010 - Proceedings of the 13th World Congress on Medical Informatics},
  address = {Cape Town, South Africa},
  journal = {Stud Health Technol Inform},
  school = {LERTIM, Faculté Médecine, Université de la Méditerranée, Marseille, France. gerard.soula@ap-hm.fr},
  year = {2010},
  volume = {160},
  number = {Pt 1},
  pages = {610--614}
}

BibTeX:
@article{Gicquel2010,
  author = {Gicquel, Q and Kergoulay, I and Pereira, S and Grandbastien, B and Berrouane, Y and Tavolacci, MP and Segond, F and Darmoni SJ and Metzger, MH},
  title = {L'apport d'un serveur multi-terminologique de santé pour un codage standardisé de données épidémiologiques - Exemple d'application en épidémiologie hospitalière},
  booktitle = {Actes ADELF-EMOIS},
  journal = {Revue d'Épidemiologie et de Santé Publique},
  year = {2010},
  volume = {58},
  number = {S1},
  pages = {S25},
  note = {ALADIN-DTH},
  url = {http://www.em-consulte.com/article/248607},
  doi = {10.1016/j.respe.2010.02.065}
}

BibTeX:
@inproceedings{Ammenwerth2010,
  author = {Ammenwerth, E and Hackl, W and Bjoern, B and Koutkias, V and Massari, P and Pechlaner, C and Riedmann, D and Saboor, S and Darmoni, SJ},
  title = {Validation of a knowledge base for advanced CPOE systems based on test cases},
  booktitle = {MEDINFO 2010 - Proceedings of the 13th World Congress on Medical Informatics},
  address = {Cape Town, South Africa},
  year = {2010}
}

BibTeX:
@inproceedings{Bousquet2010,
  author = {Bousquet, C and Sadou, E and Merabti, T and Trombert, B and Kumar, A and Darmoni, SJ and Rodrigues, JM},
  title = {Multiaxial description of the French CCAM terminology for clinical procedures and mapping on the UMLS metathesaurus},
  booktitle = {MEDINFO 2010 - Proceedings of the 13th World Congress on Medical Informatics},
  address = {Cape Town, South Africa},
  year = {2010}
}

BibTeX:
@inproceedings{Joubert2010,
  author = {Joubert, M and Merabti, T and Vandenbussche, PY and Abdoune, H and Dahamna, B and Fieschi, M and Darmoni, SJ},
  title = {Modeling and Integrating Terminologies into a French Multi-terminology Server},
  booktitle = {MEDINFO 2010 - Proceedings of the 13th World Congress on Medical Informatics},
  address = {Cape Town, South Africa},
  year = {2010}
}

BibTeX:
@inproceedings{Kerdelhue2010,
  author = {Kerdelhué, G and Lamy, JB and Venot, A and Duclos, C and Darmoni, SJ},
  title = {An iconic language for the "CISMeF Bonnes pratiques" website},
  booktitle = {EAHIL},
  year = {2010}
}

BibTeX:
@inproceedings{Merabti2010a,
  author = {Merabti, T and Darmoni, SJ},
  title = {ATC to PubMed: a bibliographic tool for drugs},
  booktitle = {AMIA},
  year = {2010},
  pages = {1174}
}

Abstract: The aim is to highlight how it is possible to reconcile ontologies
and terminologies in Life Sciences via metamodeling. The paper focuses
on the Foundational Model of Anatomy (FMA). The first part describes
the FMA ontology formalization in OWL 2. The second part presents
the Health Multi-Terminologies Portal (HMTP) of French terminologies
implemented in OWL. It explains how its FMA terminology was obtained
from the FMA ontology by reification. The FMA ontology and terminology
illustrate how ontologies and terminologies can be made compatible
via metamodeling. Advantages and possible means to bind the two views
even more closely are discussed in conclusion. To the best of our
knowledge, no complete representation of the FMA ontology and terminology
in OWL 2 existed so far.
BibTeX:
@techreport{Golbreich2010a,
  author = {Golbreich, C and Grosjean J and Darmoni, SJ},
  title = {FMA and HMTP Portal in OWL: Reconciling Ontology with Terminology in Life Sciences via Metamodeling},
  month = {June},
  year = {2010},
  url = {http://hal-lirmm.ccsd.cnrs.fr/lirmm-00534124/fr/}
}

Abstract: Representing the Foundational Model of Anatomy (FMA) in OWL 2 W3C
standard, is essential for its interoperability with other biomedical
ontologies, its design, maintenance, and quality insurance. The paper
describes the method and 'FMA-OWLizer' tool that moves the FMA to
OWL 2. One main strength of the approach is to leverage OWL expressiveness
to explicit some implicit semantics and naming conventions of the
FMA, meanwhile improving its ontological model and fixing some FMA
errors. Another originality is the flexibility and versatility of
the conversion: many options allow for producing several FMA-OWL
variants customized to users, e.g., choosing a frame or OWL source,
generating an OWL DL or OWL 2, a full or reduced FMA target, configuring
the classes definitions etc. Thus several new FMA-OWL ontologies
are available. To the best of our knowledge, no complete representation
of the entire FMA in OWL DL or OWL 2 existed so far.
BibTeX:
@techreport{Golbreich2010,
  author = {Golbreich, C and Grosjean, J and Darmoni, SJ},
  title = {Pushing the FMA-OWL Enveloppe Further},
  school = {CNRS},
  year = {2010},
  note = {Technical report},
  url = {http://hal-lirmm.ccsd.cnrs.fr/lirmm-00495056/fr/}
}

BibTeX:
@article{Kedelhue2010,
  author = {Kerdelhué, G},
  title = {CISMeF : un catalogue et index des sites médicaux de langue française},
  month = {Novembre-Décembre},
  journal = {La Santé de l'Homme},
  year = {2010},
  number = {410},
  pages = {36},
  url = {http://www.inpes.sante.fr/SLH/pdf/sante-homme-410.pdf}
}

BibTeX:
@mastersthesis{Griffon2010,
  author = {Griffon, N},
  title = {Modélisation et évaluation d'un outil de recherche d'informations au sein des dossiers patients informatisés},
  school = {University of Rouen, France},
  year = {2010},
  note = {MD thesis},
  url = {http://www.chu-rouen.fr/tibs/wp-content/uploads/vff.pdf}
}

BibTeX:
@phdthesis{Merabti2010b,
  author = {Merabti, T},
  title = {Méthodes pour la mise en relations des terminologies médicales : contribution à l'interopérabilité sémantique Inter et Intra terminologique},
  school = {University of Rouen, France},
  year = {2010},
  url = {http://www.chu-rouen.fr/tibs/wp-content/uploads/th%C3%A8se_version_finale_TM.pdf}
}

BibTeX:
@phdthesis{Sakji2010a,
  author = {Sakji, S},
  title = {Recherche d'information et indexation automatique des médicaments à l'aide de plusieurs terminologies de santé},
  school = {University of Rouen, France},
  year = {2010},
  url = {http://www.chu-rouen.fr/tibs/wp-content/uploads/Th%C3%A8se_Saoussen_SAKJI.pdf}
}

2009


Abstract: The aim of this study was to assess to what extent patients with meticillin-resistant
Staphylococcus aureus (MRSA) at respiratory sites shed viable MRSA
into the air of hospital rooms. We also evaluated whether the distance
from the patient could influence the level of contamination. Air
sampling was performed directly onto MRSA-selective agar in 24 hospital
rooms containing patients with MRSA colonization or infection of
the respiratory tract. Samplings were performed in duplicate at 0.5,
1 and 2-3 m from the patients' heads. Clinical and environmental
isolates were compared using antimicrobial resistance patterns and
pulsed-field gel electrophoresis. MRSA strains were isolated from
21 out of 24 rooms, in quantities varying from between 1 and 78 cfu/m3.
In each of the 21 rooms, at least one of the environmental isolates
was identical to a clinical isolate from the patient in that room.
There was no significant difference in MRSA counts between the distance
from the patient's head and the sampler. This study demonstrates
that most patients with MRSA infection or colonisation of the respiratory
tract shed viable MRSA into the air of their room. The results emphasise
the need to study MRSA in air in more detail in order to improve
infection control recommendations.
BibTeX:
@article{Gehanno2009b,
  author = {Gehanno, J. F. and Louvel, A. and Nouvellon, M. and Caillard, J.-F. and Pestel-Caron, M.},
  title = {Aerial dispersal of meticillin-resistant {Staphylococcus} aureus in hospital rooms by infected or colonised patients.},
  month = {March},
  journal = {The Journal of hospital infection},
  year = {2009},
  volume = {71},
  number = {3},
  pages = {256--262},
  doi = {10.1016/j.jhin.2008.11.015}
}

Abstract: But de l’étude L’exposition des personnels de soins aux risques biologiques
est inhérente à l’activité professionnelle dans ce milieu, mais les
méthodes d’évaluation de ces risques sont encore limitées. L’objectif
de ce travail est double : d’une part, élaborer un guide d’évaluation
à partir des données de la littérature biomédicale et des données
locales d’hospitalisation ou d’analyses microbiologiques, pour les
germes les plus couramment rencontrés en milieu de soins, d’autre
part, valider l’utilisation d’un impacteur mono-étage dans l’évaluation
des expositions. Matériel et méthode Ce travail s’est déroulé selon
deux grands axes : synthèse des informations existantes, identification
et synthèse des documents scientifiques existants portant sur l’exposition
des personnels de soins aux agents biologiques et sur les circonstances
des expositions, puis réalisation et validation d’un guide des expositions
a priori aux risques biologiques en milieu de soins. Utilisation
d’un impacteur mono-étage pour évaluer la présence de staphylocoques
résistant à la méthicilline dans les chambres de patients infectés
ou colonisés par ce germe. Les prélèvements ont été réalisés sur
des milieux gélosés sélectifs, et les souches retrouvées ont été
comparées aux souches portées par les patients. Résultats Les documents
de synthèse sur les expositions des soignants aux risques biologiques,
sur les contextes des expositions et sur les recommandations en termes
de vaccinations basées sur les prescriptions réglementaires et les
connaissances scientifiques ont été élaborés et sont disponibles
sur le site Internet http://wwww.chu-rouen.fr/mtph . Il concerne
une vingtaine de germes reconnus comme les principaux risques biologiques
en milieu de soins. Les résultats obtenus avec l’impacteur mono-étage
confirment qu’il peut être valablement utilisé pour mesurer l’exposition
aérienne aux germes cultivables.
BibTeX:
@article{Gehanno2009c,
  author = {Gehanno, J.-F. and Louvel, A. and Rysanek, E. and Pestel-Caron, M. and Nouvellon, M. and Kornabis, N. and Touche, S. and Ripault, B. and Buisson-Valles, I. and Sobaszek, A.},
  title = {Évaluation des risques biologiques pour les personnels de soins : de l’évaluation a priori à l’expérimentation},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2009},
  volume = {70},
  number = {1},
  pages = {36--42},
  doi = {10.1016/j.admp.2008.10.021}
}

Abstract: Objectifs L’étude avait pour but de concevoir et d’évaluer des outils
permettant d’assurer le recueil standardisé d’informations et leur
comparabilité sur le thème du maintien dans l’emploi dans les établissements
de soins. Méthode Six centres hospitaliers universitaires (CHU) ont
d’abord mis en commun leurs expériences. À partir de là, deux questionnaires
ont été réalisés : un questionnaire abordant neuf thèmes déterminants
de la politique d’aménagement des postes de travail et un questionnaire
de recueil d’informations sur les moyens humains et les compétences
mises en œuvre pour cette politique. Résultats Le premier questionnaire
a été envoyé aux médecins du travail et aux directions des ressources
humaines (DRH) de 14 CHU. Les réponses ont pu être exploitées pour
dix CHU. Le second questionnaire a été envoyé aux mêmes acteurs de
six CHU et quatre réponses ont pu être traitées. Les réponses sont
très variables et traduisent les différences d’approche d’un établissement
à l’autre. Cette variabilité commence par des définitions différentes
des postes concernés (aménagés, adaptés, appropriés…). La mise en
œuvre d’une cartographie a priori des postes aménageables paraît
vouée à l’échec. Il n’existe pas de politique générale d’évaluation
de l’efficacité des aménagements de poste ni de mise en œuvre systématique
de prévention des causes de restrictions d’aptitude. Conclusion Les
outils utilisés répondent aux besoins de mise en commun les informations
afin de progresser autour du maintien dans l’emploi. Cette progression
passera par la mutualisation des expériences. La généralisation de
ces outils passe par un travail de développement et d’adaptation
des outils à l’ensemble des hôpitaux.
BibTeX:
@article{Herin2009,
  author = {Herin, F. and Gehanno, J.-F. and Lodde, B. and Amar, A. and Laplace, V. and Soulat, J.-M.},
  title = {Maintien dans l’emploi, prévention du handicap dans les établissements hospitaliers : développement et étude préliminaire d’outils pour assurer le recueil systématique et la comparabilité des informations},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2009},
  volume = {70},
  number = {1},
  pages = {55--66},
  doi = {10.1016/j.admp.2008.10.019}
}

Abstract: La littérature a déjà démontré l’impact positif de programmes éducatifs
dirigés vers les patients coronariens1. Cependant, ceux-ci sont sous-utilisés,
et plusieurs questions sont sans réponse. Ces interventions sont-elles
délivrées de manière optimale ? Comment structurer de tels programmes
? À quelle fréquence et pendant combien de temps faut-il les instaurer
? Leur impact subsiste-t-il, même si la qualité des soins prodigués
est déjà satisfaisante (effet plafond) ?
BibTeX:
@article{Mercier2009,
  author = {Mercier, A. and Schuers, M.},
  title = {Prévention secondaire des maladies cardiovasculaires en médecine générale : résultats d'un essai contrôlé randomisé en grappes.},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2009},
  number = {88 suppl 2},
  pages = {68--9}
}

Abstract: Introduction The purpose of this study was to report on the qualities
of various search strategies and keywords to find return to work
(RTW) studies in the Medline bibliographic database. Methods We searched
Medline for articles on RTW published in 2003, using multiple search
strings, and hand searched 16 major periodicals of rehabilitation
or occupational medicine. Among the retrieved articles, those considered
to be relevant, were pooled in a Gold Standard Database. From this
database, we identified candidate text words or MeSH terms for search
strategies using a word frequency analysis of the abstracts and a
MEDLINE categorization algorithm. According to the frequency of identified
terms, searches were run for each term independently and in combination.
We computed Recall, Precision, and number needed to read (NNR = 1/Precision)
of each keyword or combination of keywords. Results Among the 8,073
articles examined, 314 (3.9 were considered relevant and included
in the Gold Standard Database. The search strings ("Rehabilitation,
Vocational" [MeSH]), ("Return to work"[All]) and ("Back to work"[All])
had Recall/Precision ratio of 30.46/19.11, 59.55/87.38 and 3.18/90.91
respectively. Their combination with the Boolean operator OR yielded
to a Recall/Precision ratio of 73.89/58.44% and a NNR of 1.7. For
the end user requiring comprehensive literature search, the best
string was ("Return to work" OR "Back to work" OR "Rehabilitation,
vocational"[MeSH] OR "rehabilitation"[Subheading]), with a Recall
of 88.22% and a NNR of 18. Conclusions No single MeSH term is available
to help the physician to identify relevant studies on RTW in Medline.
Locating these types of studies requires the use of various MeSH
and non-MeSH terms in combination to obtain a satisfactory Recall.
Nevertheless, enhancing the Recall of search strategies may lead
to lower Precision, and higher NNR, although with a non linear trend.
This factor must be taken into consideration by the end user in order
to improve the cost-effectiveness ratio of the search in Medline.
BibTeX:
@article{Gehanno2009,
  author = {Gehanno, Jean-François and Rollin, Laetitia and Le Jean, Tony and Louvel, Alexandre and Darmoni,Stefan and Shaw, William},
  title = {Precision and Recall of Search Strategies for Identifying Studies on Return-To-Work in Medline.},
  month = {Apr},
  journal = {J Occup Rehabil},
  school = {Institute of Occupational Health, Rouen University Hospital, 1 rue de Germont, 76000, Rouen, France, jean-francois.gehanno@chu-rouen.fr.},
  year = {2009},
  volume = {19},
  number = {3},
  pages = {223-230},
  url = {http://dx.doi.org/10.1007/s10926-009-9177-0},
  doi = {10.1007/s10926-009-9177-0}
}

BibTeX:
@article{Humphrey2009,
  author = {Humphrey, S and Névéol, A and Gobeil, J and Ruch, P and Darmoni, SJ and Browne, A},
  title = {Comparing a Rule Based vs. Statistical System for Automatic Categorization of MEDLINE Documents According to Biomedical Specialty},
  month = {july},
  journal = {Journal of the American Society for Information Science and Technology},
  year = {2009},
  volume = {60},
  number = {12},
  pages = {2530-2539},
  doi = {10.1002/asi.21170}
}

BibTeX:
@article{Rollin2009a,
  author = {Rollin, L and Darmoni, SJ and Caillard, JF and Gehanno, JF},
  title = {Fate of abstracts presented at the ICOH International Meeting: are they followed by publication in peer-reviewed journals?},
  journal = {Scandinavian Journal of Work, Environment \& Health},
  year = {2009},
  volume = {35},
  number = {6},
  pages = {461-465},
  url = {http://www.sjweh.fi/show_abstract.php?abstract_id=1362},
  doi = {10.5271/sjweh.1362}
}

BibTeX:
@article{Sibert2009,
  author = {Sibert, L and Giorgi, R and Dahamna, B and Doucet, J and Charlin, B and Darmoni, SJ},
  title = {Is a Web-based Concordance test feasible to assess therapeutic decision-making skills in a French context?},
  month = {April},
  journal = {Medical Teacher},
  year = {2009},
  volume = {31},
  number = {4},
  pages = {162-8},
  doi = {10.1080/01421590802572783}
}

Abstract: SIGAPS is a bibliometric score that aims at making an inventory, evaluating
and promoting scientific publications of hospitals that perform research.
It has become a major stake in France since it is one of the most
important components of the MERRI (Mission Training, Research, Reference
and Innovation) founding of hospitals. This score is based on the
points attributed to the authors of articles published in journals
indexed in Medline, according to the rank of the authors and the
Impact Factor of the journal. OBJECTIVES: to compare the reliability
of the score when applying different way of computing it, and different
weights for the rank or the Impact Factor. MATERIAL AND METHODS:
we computed the scores of all the physicians of a University Hospital,
using the rules that are actually applied at the national level.
We then used 4 different scenarios, with different weight given to
the rank of authors or the Impact Factor. We compared the scores
obtained by each author according to the different scenarios with
the Spearman's rank and Pearson's correlation coefficients. RESULTS:
The score is not significantly affected when no points are given
to the fourth authors and above, when the last author get more points
or to change the points according to the Impact Factor of the journal.
CONCLUSION: The different scenarios do not lead to significant changes
for the physicians' scores, and therefore for the cumulated score
of the hospital. Despite the well known limits of bibliometric indicators,
the SIGAPS score appears reliable to compare the hospitals for founding
decisions.
BibTeX:
@article{Darmoni2009,
  author = {Darmoni, SJ and Ladner, J and Devos, P and Gehanno, JF},
  title = {Robustesse du score SIGAPS, critère bibliométrique majeur pour l'enveloppe MERRI des CHU},
  month = {Jul-Aug},
  journal = {Presse Med},
  school = {GCSIS, TIBS, LITIS EA 4108, Université de Rouen, France.},
  year = {2009},
  volume = {38},
  number = {7-8},
  pages = {1056-61},
  url = {http://dx.doi.org/10.1016/j.lpm.2009.03.011},
  doi = {10.1016/j.lpm.2009.03.011}
}

BibTeX:
@article{Gehanno2008a,
  author = {Gehanno, JF and Kerdelhue, G and Darmoni, SJ and Fantoni, S and Frimat, P and Caillard, JF},
  title = {Veille documentaire en santé au travail des personnels de santé},
  month = {Février},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2009},
  volume = {70},
  pages = {43-47},
  url = {http://www.sciencedirect.com/science/article/B8JFG-4V4M33G-1/2/0f2dccbfd9fa5b927ae379c705b567ba},
  doi = {10.1016/j.admp.2008.10.020}
}

Abstract: The 2004 statute that created the French National Authority for Health
(HAS, Haute Autorité de Santé) required it to establish a procedure
for the certification of health-related web sites. The HAS established
a procedure based on the HONcode certification scheme set up by the
Health On the Net Foundation, with which HAS has a partnership agreement.
The HONcode includes eight principles that govern the quality of
online heath information and its presentation (quality of the production
process). The collaboration between HAS and HON has already led to
improvements in a large number of web sites in France and to their
certification. The main advantages of certification for site publishers
are better site quality and enhanced credibility rather than a larger
audience. Quality certification has little impact on the choice of
site by Internet users as they tend to use search engines to find
health-related information. Future development of the procedure should
work to increase the value of certification both by improving the
quality of sites and in signaling quality to Internet users.
BibTeX:
@article{Nabarette2009,
  author = {Nabarette, Hervé and Romaneix, François and Boyer, Célia and Darmoni, Stéphan Jacques and Rémy, Pierre-Louis and Caniard, Etienne},
  title = {Certification des sites dédiés à la santé en France.},
  month = {Aug},
  journal = {Presse Med},
  school = {Haute autorité de santé, F-93218 Saint-Denis La Plaine Cedex, France.},
  year = {2009},
  url = {http://www.hon.ch/Conf/Docs/PresseMedicale_10/Article10.pdf},
  doi = {10.1016/j.lpm.2009.06.008}
}

BibTeX:
@article{Pauchet,
  author = {Pauchet, A and El Abed, M and Merabti, T and Prieur, E and Lecroq, T and Darmoni, SJ},
  title = {Identification de répétitions dans les navigations au sein d'un catalogue de santé},
  journal = {RIA (Revue d'Intelligence Artificielle)},
  year = {2009},
  volume = {23},
  number = {1},
  pages = {113-132},
  url = {http://ria.revuesonline.com/article.jsp?articleId=12858},
  doi = {10.3166/ria.23.113-132}
}

BibTeX:
@article{Sakji2009a,
  author = {Sakji, S and Thirion, B and Dahamna, B and Darmoni, SJ},
  title = {Recherche des sources d'information institutionnelle de santé françaises Le site Internet CISMeF},
  month = {Octobre},
  journal = {Presse Médicale},
  year = {2009},
  volume = {38},
  number = {10},
  pages = {1443-1450},
  doi = {10.1016/j.lpm.2009.05.014}
}

Abstract: Adverse Drug Events (ADE) represent a key problem in Public Health.
The detection and prevention of ADE is a real challenge for hospitals
and healthcare professionals. Healthcare Information and Communication
Technologies can contribute to reduce the incidence of preventable
ADE. During this workshop, we will discuss the various aspects of
detection of ADE through methods like data and semantic mining in
medical databases; the possibility of preventing ADE by using clinical
decision support systems; the importance of Human Factors Engineering
and the contextualization of knowledge. Examples and demonstrations
will come from the European Project PSIP, devoted to the detection
and prevention of ADE in Hospitals.
BibTeX:
@inproceedings{Beuscart2009,
  author = {Beuscart, R and McNair, P and Darmoni, SJ and Koutkia, V and Maglaveras, N and Beuscart-Zephir, MC and Nohr, C},
  title = {Patient safety: detection and prevention of adverse drug events.},
  booktitle = {MIE2009},
  journal = {Stud Health Technol Inform},
  publisher = {IOS Press},
  school = {University Hospital, INSERM CIC-IT807, UDSL, Lille, France.},
  year = {2009},
  volume = {150},
  pages = {968--971},
  doi = {10.3233/978-1-60750-044-5-968}
}

BibTeX:
@inproceedings{Darmoni2009b,
  author = {Darmoni, SJ and Joubert, M and Dahamna, B and Delahousse, J and Fieschi, M},
  title = {SMTS: a French Health Multi-terminology Server},
  booktitle = {AMIA symp.},
  publisher = {IOS Press},
  year = {2009},
  pages = {808},
  note = {InterSTIS}
}

Abstract: Background: In the specific context of developing quality-controlled
health gateways, several standards must be respected (e.g. Dublin
Core for metadata element set; thesaurus MeSH as the controlled vocabulary
to index Internet resources; HON code to accredit quality of health
Web sites). These standards were applied to create the CISMeF Web
site (French acronym for Catalog & Index of Health Internet resources
in French). Objective: In this work, the strategic shift of the CISMeF
team is intended to index and retrieve French resources not anymore
with a single terminology (MeSH thesaurus) but with the main health
terminologies available in French (ICD 10, SNOMED International,
CCAM, ATC). Methods & Results: Since 2005, we have developed the
French Multi-Terminology Indexer (F-MTI), using a multi-terminology
approach and mappings between health terminologies. This tool is
used for automatic indexing and information retrieval. Conclusion:
Since the last quarter of 2008, F-MTI is daily used in the CISMeF
production environment and is connected to a French Health Multi-Terminology
Server.
BibTeX:
@inproceedings{Darmoni2009a,
  author = {Darmoni, SJ and Sakji, S and Pereira, S and Merabti T and Prieur E and Joubert M and Thirion B},
  title = {Multiple terminologies in an health portal: automatic indexing and information retrieval},
  booktitle = {Artificial Intelligence in Medicine},
  address = {Verona, Italy},
  month = {July},
  publisher = {Springer},
  year = {2009},
  series = {Lecture Notes in Computer Science},
  pages = {255-259},
  note = {PSIP. InterSTIS},
  doi = {10.1007/978-3-642-02976-9_37}
}

BibTeX:
@inproceedings{Durieux2009,
  author = {Durieux, V and Kerdelhué, G},
  title = {Access to health information on the Internet: can social bookmarking systems replace expert gateways?},
  booktitle = {Workshop EAHIL},
  address = {Dublin, Ireland},
  month = {June},
  year = {2009},
  url = {http://www.eahil2009.ie/images/Eahil/Images/papers/fri8/durieux_paper.pdf}
}

BibTeX:
@inproceedings{Gehanno2009a,
  author = {Gehanno, JF, Kerdelhué, G Darmoni, SJ},
  title = {Relevance of Google Customized Search Engine vs. CISMeF Quality-Controlled Health Gateway},
  booktitle = {MIE2009},
  journal = {Stud Health Technol Inform},
  year = {2009},
  volume = {150},
  pages = {312-6},
  doi = {10.3233/978-1-60750-044-5-312}
}

BibTeX:
@inproceedings{Joubert2009a,
  author = {Joubert, M and Abdoune, H and Merabti, T and Darmoni, SJ and Fieschi, M},
  title = {Assisting the Translation of SNOMED CT into French using UMLS and four Representative French-language Terminologies},
  booktitle = {AMIA symp.},
  publisher = {IOS Press},
  year = {2009},
  pages = {291-295},
  note = {InterSTIS}
}

BibTeX:
@inproceedings{Merabti2009a,
  author = {Merabti, Tand Letord, C and Abdoune, H and Lecroq, T and Joubert, M and Darmoni, SJ},
  title = {Projection and inheritance of SNOMED CT Relations between MeSH Terms},
  booktitle = {MIE2009},
  journal = {Stud Health Technol Inform},
  publisher = {IOS Press},
  year = {2009},
  volume = {150},
  pages = {233-7},
  note = {InterSTIS},
  doi = {10.3233/978-1-60750-044-5-233}
}

Abstract: Summary of Product Characteristics (SPC) indexing enables to extract
all the information needed to analyze a prescription and find some
inappropriate medications. We evaluate a French Multi-Terminology
Indexer tool (F-MTI) for SPC automatic indexing. This tool uses a
dictionary containing the textual forms that are likely to appear
in natural language text for the drug clinical particular terms contained
in the Vidal thesaurus (TUV). We developed a method to automatically
generate this dictionary. The evaluation showed a precision of 52.9%
and a recall of 46.2%. F-MTI will be integrated in a semi-automatic
indexing tool.
BibTeX:
@inproceedings{Pereira2009a,
  author = {Pereira, S and Plaisantin, B and Korchi, M and Rozanes, N and Serrot, E and Joubert, M and Darmoni, SJ},
  title = {Automatic construction of dictionnaries, application to product characteristics indexing},
  booktitle = {MIE2009},
  journal = {Stud Health Technol Inform},
  publisher = {IOS Press},
  year = {2009},
  volume = {150},
  pages = {512-6},
  doi = {10.3233/978-1-60750-044-5-512}
}

BibTeX:
@inproceedings{Pereira2009b,
  author = {Pereira, S and Sakji, S and Névéol, A and Kergoulay, I and Kerdelhué, G and Serrot, E and Joubert, M and Darmoni SJ},
  title = {Multi-terminology indexing for the assignment of MeSH descriptors to medical abstracts in French},
  booktitle = {AMIA symp.},
  publisher = {IOS Press},
  year = {2009},
  pages = {521-525},
  note = {PSIP}
}

BibTeX:
@inproceedings{proux-EtAl:2009:BiomedicalIE,
  author = {Proux, Denys and Marchal, Pierre and Segond, Fr\'{e}d\'{e}rique and Kergourlay, Ivan and Darmoni, St\'{e}fan and Pereira, Suzanne and Gicquel, Quentin and Metzger, Marie H\'{e}l\`{e}ne},
  title = {Natural Language Processing to Detect Risk Patterns Related to Hospital Acquired Infections},
  booktitle = {Proceedings of the Workshop on Biomedical Information Extraction},
  address = {Borovets, Bulgaria},
  month = {September},
  publisher = {Association for Computational Linguistics},
  year = {2009},
  pages = {35--41},
  url = {http://www.aclweb.org/anthology/W09-4506}
}

BibTeX:
@inproceedings{Sakji2009,
  author = {Sakji, S and Dirieh Dibad, AD and Kergourlay, I and Joubert, M and Darmoni, SJ},
  title = {Information Retrieval in Context Using Various Health Terminologies},
  booktitle = {RCIS, International Conference on Research Challenges in Information Science},
  address = {Fez, Morocco},
  month = {April},
  publisher = {IEEE},
  year = {2009},
  pages = {453-458},
  note = {PSIP},
  doi = {10.1109/RCIS.2009.5089310}
}

Abstract: Objective: The objective of this work is to create a bilingual (French/English)
Drug Information Portal (DIP), in a multi-terminological context
and to emphasize its exploitation by an ATC automatic indexing allowing
having more pertinent information about substances, organs or systems
on which drugs act and their therapeutic and chemical characteristics.
Methods: The development of the DIP was based on the CISMeF portal,
which catalogues and indexes the most important and quality-controlled
sources of institutional health information in French. DIP has created
specific functionalities and uses specific drugs terminologies such
as the ATC classification which used to automatic index the DIP resources.
Results: DIP is the result of collaboration between the CISMeF team
and the VIDAL Company, specialized in drug information. DIP is conceived
to facilitate the user information retrieval. The ATC automatic indexing
provided relevant results in 76% of cases. Conclusion: Using multi-terminological
context and in the framework of the drug field, indexing drugs with
the appropriate codes or/and terms revealed to be very important
to have the appropriate information storage and retrieval. The main
challenge in the coming year is to increase the accuracy of the approach.
BibTeX:
@inproceedings{Sakji2009c,
  author = {Sakji, S and Letord, C and Dahamna, B and Kergourlay, I and Pereira, S and Joubert, M and Darmoni, SJ},
  title = {Automatic indexing in a drug information portal.},
  journal = {Stud Health Technol Inform},
  publisher = {IOS Press},
  school = {GCSIS, TIBS, LITIS EA 4108, Biomedical Research Institute, Rouen. France.},
  year = {2009},
  volume = {148},
  pages = {112--122},
  note = {PSIP},
  doi = {10.3233/978-1-60750-043-8-112}
}

BibTeX:
@inproceedings{Sakji2009b,
  author = {Sakji, S and Letord, C and Pereira , S and Dahamna, B and Joubert, M and Darmoni, SJ},
  title = {Drug Information Portal in Europe: information retrieval with multiple health terminologies},
  booktitle = {MIE2009},
  journal = {Stud Health Technol Inform},
  publisher = {IOS Press},
  year = {2009},
  volume = {150},
  pages = {497-501},
  note = {PSIP.},
  doi = {10.3233/978-1-60750-044-5-497}
}

BibTeX:
@inproceedings{Thirion2009,
  author = {Thirion, B and Robu, I and Darmoni, SJ},
  title = {Optimization of the PubMed Automatic Term Mapping},
  booktitle = {MIE2009},
  journal = {Stud Health Technol Inform},
  year = {2009},
  volume = {150},
  pages = {238-42},
  doi = {10.3233/978-1-60750-044-5-238}
}

BibTeX:
@inproceedings{Dirieh2009,
  author = {Dirieh Dibad, AD and Sakji, S and Prieur, E and Pereira, S and Joubert, M and Darmoni, SJ},
  title = {Recherche d'information multi-terminologique en contexte : Etude préliminaire},
  booktitle = {Risques, technologies de l'information pour les pratiques médicales : comptes rendus des treizièmes journées francophones d'informatique médicale (JFIM)},
  address = {Nice, France},
  month = {Avril},
  publisher = {Springer},
  year = {2009},
  series = {Informatique et santé},
  volume = {17},
  pages = {101-112},
  note = {PSIP},
  url = {http://www.springerlink.com/content/p582765854143840/},
  doi = {10.1007/978-2-287-99305-3_10}
}

BibTeX:
@inproceedings{Joubert2009,
  author = {Joubert, M and Dahamna, B and Delahousse, J and Fieschi, M and Darmoni SJ},
  title = {SMTS® : Un Serveur Multi-Terminologies de Santé},
  booktitle = {Risques, technologies de l'information pour les pratiques médicales : comptes rendus des treizièmes journées francophones d'informatique médicale (JFIM)},
  address = {Nice, France},
  month = {Avril},
  year = {2009},
  series = {Informatique et santé},
  volume = {17},
  pages = {47-56},
  note = {InterSTIS},
  url = {http://www.springerlink.com/content/v32879v42214l1r3},
  doi = {10.1007/978-2-287-99305-3_5}
}

BibTeX:
@inproceedings{Merabti2009,
  author = {Merabti, T and Abdoune, H and Lecroq, T and Joubert, M and Darmoni, SJ},
  title = {Projection des relations SNOMED CT entre les termes de deux terminologies (CIM10 et SNOMED 3.5)},
  booktitle = {Risques, technologies de l'information pour les pratiques médicales : comptes rendus des treizièmes journées francophones d'informatique médicale (JFIM)},
  address = {Nice, France},
  month = {Avril},
  year = {2009},
  series = {Informatique et santé},
  volume = {17},
  pages = {79-88},
  note = {InterSTIS},
  url = {http://www.springerlink.com/content/g817q31010448324},
  doi = {10.1007/978-2-287-99305-3_8}
}

BibTeX:
@inproceedings{Merabti2009b,
  author = {Merabti, T and Darmoni, SJ},
  title = {Web sémantique au sein de CISMeF},
  booktitle = {i-expo, salon de l'information numérique},
  month = {Juin},
  year = {2009}
}

BibTeX:
@inproceedings{Pereira2009,
  author = {Pereira, S and Massari, P and Buemi, A and Dahamna, B and Serrot, E and Joubert, M and Darmoni SJ},
  title = {F-MTI : outil d'indexation multi-terminologique : application à l'indexation automatique de la SNOMED},
  booktitle = {Risques, technologies de l'information pour les pratiques médicales : comptes rendus des treizièmes journées francophones d'informatique médicale (JFIM)},
  address = {Nice, France},
  month = {Avril},
  year = {2009},
  series = {Informatique et santé},
  volume = {17},
  pages = {57-67},
  url = {http://www.springerlink.com/content/q673u2tp56124t63},
  doi = {10.1007/978-2-287-99305-3_6}
}

BibTeX:
@inproceedings{Letord2009,
  author = {Letord, C and Sakji, S and Pereira, S and Dahamna, B and Kergoulay, I and Darmoni, SJ},
  title = {A Drug Information Portal in Europe},
  booktitle = {AMIA symp.},
  publisher = {IOS Press},
  year = {2009},
  pages = {931},
  note = {PSIP}
}

BibTeX:
@inproceedings{Metzger2009,
  author = {Metzger, MH and Gicquel, Q and Proux, D and Pereira, S and Kergoulay, I and Serrot, E and Segond, F and Darmoni SJ},
  title = {Development of an Automated Detection Tool for Health Care-Associated Infections Based on Screening Natural Language Medical Reports.},
  booktitle = {AMIA symp.},
  publisher = {IOS Press},
  year = {2009},
  pages = {967},
  note = {ALADIN}
}

BibTeX:
@inproceedings{Rollin2009,
  author = {Rollin, L and Darmoni, S and Caillard, JF and Gehanno, JF},
  title = {Fate of abstracts presented at the ICOH International Meetings: are they followed by publication in peer-reviewed journals?},
  booktitle = {ICOH 2009 congress},
  year = {2009}
}

BibTeX:
@article{Sibert2009a,
  author = {Sibert, L and Dahamna, B and Doré, B and Darmoni SJ},
  title = {Le test de concordance en urologie : du format papier à l'application en ligne},
  journal = {Pédagogie Médicale},
  year = {2009},
  volume = {10},
  number = {Suppl. 1},
  doi = {10.1051/pmed/20099993}
}

2008


Abstract: One of the most significant recent advances in health information
systems has been the shift from paper to electronic documents. While
research on automatic text and image processing has taken separate
paths, there is a growing need for joint efforts, particularly for
electronic health records and biomedical literature databases. This
work aims at comparing text-based versus image-based access to multimodal
medical documents using state-of-the-art methods of processing text
and image components. A collection of 180 medical documents containing
an image accompanied by a short text describing it was divided into
training and test sets. Content-based image analysis and natural
language processing techniques are applied individually and combined
for multimodal document analysis. The evaluation consists of an indexing
task and a retrieval task based on the "gold standard" codes manually
assigned to corpus documents. The performance of text-based and image-based
access, as well as combined document features, is compared. Image
analysis proves more adequate for both the indexing and retrieval
of the images. In the indexing task, multimodal analysis outperforms
both independent image and text analysis. This experiment shows that
text describing images can be usefully analyzed in the framework
of a hybrid text/image retrieval system.
BibTeX:
@article{Neveol2009,
  author = {Névéol, A and Deserno, T and Darmoni, SJ and Güld, M and Aronson, AR},
  title = {Natural language processing vs. content-based image analysis for medical document retrieval},
  month = {sep},
  journal = {Journal of the American Society for Information Science and Technology},
  year = {2008},
  volume = {60},
  number = {1},
  pages = {123--134},
  doi = {10.1002/asi.20955}
}

BibTeX:
@article{SMITH2008,
  author = {SMITH, DR and GEHANNO, JF and TAKAHASHI, K},
  title = {Bibliometric Research in Occupational Health},
  journal = {Industrial Health},
  year = {2008},
  volume = {46},
  number = {6},
  pages = {519-522},
  doi = {10.2486/indhealth.46.519}
}

BibTeX:
@article{Abbas2008,
  author = {Abbas, D and Gehanno, J-F and Caillard, J-F and Beuret-Blanquart, F},
  title = {Caractéristiques des personnes atteintes d'une sclérose en plaques selon la situation professionnelle.},
  journal = {Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique},
  year = {2008},
  volume = {51},
  number = {5},
  pages = {386--93},
  doi = {10.1016/j.annrmp.2008.03.004}
}

Abstract: Over the last decade, Internet has become a significant source of
information in numerous fields, including health. The French heath
-catalogue CISMeF provides medical documents indexing and searching
capabilities. The images represent a significant portion of the on-line
medical knowledge and a valuable component of diagnosis and teaching.
To enrich the Doc'CISMeF search engine with a "search -by-image-criteria"
capability, we developed the MedIC module to allow the users to search
for documents using image-related criteria. To extract accurate image
descriptors, the MedIC architecture takes into consideration both
the image itself and the corresponding image-related textregions.
In this paper we present our approach for text-region extraction
and interpretation, as well as the results obtained for image medical
modality extraction.
BibTeX:
@article{Florea2006c,
  author = {Florea, F and Buzuloiu, V and Rogozan, A and Cornea, V and Bensrhair, A and Darmoni, SJ},
  title = {Extraction and interpretation of image-related medical knowledge from on-line health-documents},
  journal = {UPB Scientific Bulletin, Series C: Electrical Engineering},
  year = {2008},
  volume = {70},
  number = {2},
  pages = {29-40},
  url = {http://www.scientificbulletin.upb.ro/rev_docs_arhiva/full96719.pdf}
}

Abstract: Objectifs La définition des compétences professionnelles requises
par les médecins du travail et des besoins pédagogiques dans leur
formation initiale a fait l’objet de plusieurs études en Europe ou
aux États-Unis ces dix dernières années. Ces études n’ont toutefois
pas pris en compte les besoins de l’ensemble des parties concernées.
Nous avons donc entrepris de définir les besoins éducatifs des futurs
médecins du travail, en impliquant l’ensemble des groupes professionnels
concernés. Matériels et méthodes Une première liste de compétences
a été élaborée par des enseignants de médecine du travail, sur la
base des travaux menés en Europe, aux États-Unis et en Asie. Cette
liste a ensuite été soumise à des médecins du travail en formation,
des médecins en exercice, des employeurs, des représentants de salariés
et des directeurs de services interentreprises, par une approche
de type groupes de discussion dirigée ( focus group ). Six réunions
ont été organisées au total et les avis des groupes ont ensuite été
incorporés au document initial. Résultats La méthode a été très bien
acceptée par l’ensemble des groupes, qui ont souligné son intérêt
et la nécessité de la démarche de modernisation des objectifs d’enseignement
de la médecine du travail. Trente-quatre items présents dans la liste
initiale ont été modifiés ou supprimés, et des notions concernant
les contraintes psychiques et organisationnelles ont été ajoutées.
La lisibilité de la liste initiale a été notablement améliorée. Discussion
La technique des groupes de discussion dirigée a confirmé son intérêt
dans cette démarche de définition des compétences et l’implication
de la plupart des partenaires impliqués dans la santé au travail
permet une approche consensuelle. L’importance du nombre d’objectifs
pédagogiques ainsi définis rend nécessaire une réflexion sur leur
répartition entre formation initiale et formation continue.
BibTeX:
@article{Gehanno2008b,
  author = {Gehanno, JF and Weber, J and Sobaszek, A and Cantineau, A and Sibert, L and Caillard, JF},
  title = {Détermination des besoins éducatifs des futurs médecins du travail par une méthode de groupes de discussion dirigée},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2008},
  volume = {69},
  number = {3},
  pages = {423-37},
  doi = {10.1016/j.admp.2008.05.005}
}

BibTeX:
@article{Gehanno2008g,
  author = {Gehanno, J.-F.},
  title = {Le médecin du travail en milieu hospitalier face aux risques biologiques émergents, hors pandémie grippale},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2008},
  volume = {69},
  number = {2},
  pages = {345--346},
  doi = {10.1016/j.admp.2008.03.025}
}

BibTeX:
@article{Gehanno2008f,
  author = {Gehanno, J.-F. and Caillard, J.-F.},
  title = {Evidence-based medicine et évaluation des pratiques professionnelles},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2008},
  volume = {69},
  number = {2},
  pages = {140--142},
  doi = {10.1016/j.admp.2008.03.042}
}

BibTeX:
@article{Letord2008,
  author = {Letord, C and Sakji, S and Pereira, S and Dahamna, B and Kergourlay, I and Darmoni, SJ},
  title = {Recherche d'information multi-terminologique : application à un portail d'information sur le médicament en Europe},
  journal = {Ingénierie et Recherche Biomédicale / BioMedical Engineering and Research},
  year = {2008},
  number = {29},
  pages = {350-356},
  note = {PSIP},
  doi = {10.1016/j.irbm.2008.10.001}
}

BibTeX:
@article{Mancini2008,
  author = {Mancini, Julien and Darmoni, Stéfan and Chaudet, Hervé and Fieschi, Marius},
  title = {Le paradoxe de la « T2A bibliométrique » SIGAPS : un risque d'effet délétère sur la recherche française ?},
  month = {Nov},
  journal = {Presse Med},
  school = {Aix-Marseille Université, Faculté de Médecine, Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information Médicale (LERTIM, EA 3283) F-13385 Marseille cedex 05, France; Assistance Publique - Hôpitaux de Marseille, Hôpital de la Timone, Service de Santé Publique et d'Information Médicale, F-13000 Marseille, France.},
  year = {2008},
  url = {http://dx.doi.org/10.1016/j.lpm.2008.10.005},
  doi = {10.1016/j.lpm.2008.10.005}
}

Abstract: The objective of this work was to study the use of the Internet and
the quality of the websites for postgraduate public health courses
in France, and to compare them with equivalent courses in the United
States of America. Between June 2004 and January 2005, the authorized
public health diplomas proposed in France and in the United States
were inventoried and listed, and then all websites of these public
health diplomas were systematically visited and reviewed using a
standardized questionnaire. In France, 36 public health courses (7
post graduate diplomas [DEA], 13 Masters degrees [DESS] and 16 masters
of public health [MPH]) were identified and selected from 53 websites.
Information on student profiles, prerequisite skills, the courses'
curricula and program descriptions and the potential career opportunities
were more frequently available for the MPH compared to the DEA and
DESS. In United States, 66 MPH and 127 Master of Science in Public
Health (MSPH) programs were accredited. The target public and validation
methods were more often indicated on the American sites, while the
prerequisite skills were more frequently found on the French sites.
The recent implementation of the LMD (Bachelor's-Masters-Doctoral
degrees) education system in France has encouraged the utilisation
of Internet as an information and communications tool for the presentation
and marketing of these new diplomas.
BibTeX:
@article{Rongere2008,
  author = {Rongère, Julie and Tavolacci, MP and Douyère, M and Thirion, B and Darmoni, SJ and Ladner, J},
  title = {Utilisation et qualité des sites présentant l'offre de formations en santé publique.},
  journal = {Santé Publique},
  school = {CHU Hôpital Charles Nicolle, DESP-1, rue de Germont, 76031 Rouen cedex.},
  year = {2008},
  volume = {20},
  number = {5},
  pages = {465--474},
  doi = {10.3917/spub.085.0465}
}

BibTeX:
@article{Sabourin2008,
  author = {Sabourin, JC and Darmoni, SJ},
  title = {Avec le score SIGAPS : c'est le moment de publier dans les Annales de pathologie !},
  month = {April},
  journal = {Annales de Pathologie},
  year = {2008},
  volume = {28},
  pages = {77-78},
  doi = {10.1016/j.annpat.2008.05.001}
}

BibTeX:
@article{Thirion2008,
  author = {Thirion, B},
  title = {L'Europe des bibliothèques de santé},
  journal = {BBF},
  year = {2008},
  volume = {53},
  number = {1},
  pages = {38-40},
  url = {http://bbf.enssib.fr/sdx/BBF/frontoffice/2008/01/document.xsp?id=bbf-2008-01-0038-007/2008/01/fam-dossier/dossier&statutMaitre=non&statutFils=non}
}

BibTeX:
@phdthesis{Pereira2008,
  author = {Pereira, S},
  title = {Indexation multi-terminologique de concepts en santé},
  school = {Université de Rouen},
  year = {2008},
  url = {http://suzanne.b.pereira.free.fr/Pereirathese.pdf}
}

BibTeX:
@inproceedings{Gehanno2008d,
  author = {Gehanno, JF},
  title = {Teaching Evidence Based Medicine in Occupational Health.},
  booktitle = {EASOM Summer School},
  address = {Amsterdam, Netherland},
  month = {August},
  year = {2008}
}

BibTeX:
@inproceedings{Gehanno2008,
  author = {Gehanno, JF and Kerdelhue, G and Letord, C and Fantoni, S and Frimat, P},
  title = {A web site to follow-up literature in occupational health for healthcare workers},
  booktitle = {8th International Conference on Education and Training in Occupational Health},
  address = {Glasgow, UK},
  month = {April},
  year = {2008},
  url = {http://www.gla.ac.uk/icoh2008/}
}

Abstract: Objectives: The aim of this study is to provide to indexers MeSH terms
to be considered as major ones in a list of terms automatically extracted
from a document. Material and methods: We propose a method combining
symbolic knowledge - the UMLS Metathesaurus and Semantic Network
- and statistical knowledge drawn from co-occurrences of terms in
the CISMeF database (a French-language quality-controlled health
gateway) using data mining measures. The method was tested on CISMeF
corpus of 293 resources. Results: There was a proportion of 0.37
0.26 major terms in the processed records. The method produced lists
of terms with a proportion of terms initially pointed out as major
of 0.54 0.31. Discussion: The method we propose reduces the number
of terms, which seem not useful for content description of resources,
such as ?check tags?, but retains the most descriptive ones. Discarding
these terms is accounted for by: 1) the removal by using semantic
knowledge of associations of concepts bearing no real medical significance,
2) the removal by using statistical knowledge of nonstatistically
significant associations of terms. Conclusion: This method can assist
effectively indexers in their daily work and will be soon applied
in the CISMeF system.
BibTeX:
@inproceedings{Michel2008,
  author = {Joubert, M and Darmoni, SJ and Avillach, P and Dahamna, B and Fieschi, M},
  title = {Using Knowledge for Indexing Health Web Resources in a Quality-Controlled Gateway},
  booktitle = {eHealth Beyond the Horizon - Get IT There - Proceedings of MIE2008 - The XXIst International Congress of the European Federation for Medical Informatics},
  address = {Göteborg, Sweden},
  month = {May},
  year = {2008},
  series = {Studies in Health Technology and Informatics},
  volume = {136},
  pages = {205 - 210},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=8724}
}

Abstract: Among the numerous new functionalities of the Internet, commonly called
Web 2.0, Web syndication illustrates the trend for better and faster
information sharing. Web feeds (a.k.a RSS feeds), which were used
mostly on weblogs at first, are now also widely used in academic,
scientific and institutional websites such as PubMed. As very few
French language feeds were listed or catalogued in the Health field
by the year of 2007, it was decided to implement them in the quality-controlled
health gateway CISMeF ([French] acronym for Catalogue and Index of
French Language Health Resources on the Internet). Furthermore, making
full use of the nature of Web syndication, a Web feed aggregator
was put online in to provide a dynamic news gateway called "CISMeF
actualités" (http://www.chu-rouen.fr/actualites/). This article describes
the process to retrieve and implement the Web feeds in the catalogue
and how its terminology was adjusted to describe this new content.
It also describes how the aggregator was put online and the features
of this news gateway. CISMeF actualités was built accordingly to
the editorial policy of CISMeF. Only a part of the Web feeds of the
catalogue were included to display the most authoritative sources.
Web feeds were also grouped by medical specialties and by countries
using the prior indexing of websites with MeSH terms and the so-called
metaterms. CISMeF actualités now displays 131 Web feeds across 40
different medical specialities, coming from 5 different countries.
It is one example, among many, that static hypertext links can now
easily and beneficially be completed, or replaced, by dynamic display
of Web content using syndication feeds.
BibTeX:
@inproceedings{Kerdelhue2008,
  author = {Kerdelhué, G and Thirion, B and Dahamna, B and Darmoni, SJ},
  title = {Cataloguing and displaying Web feeds from French language health sites: a Web 2.0 add-on to a health gateway},
  booktitle = {eHealth Beyond the Horizon - Get IT There - Proceedings of MIE2008 - The XXIst International Congress of the European Federation for Medical Informatics},
  address = {Göteborg, Sweden},
  month = {May},
  year = {2008},
  series = {Studies in Health Technology and Informatics},
  volume = {136},
  pages = {33 - 38},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=8694}
}

Abstract: Patient medical record systems (MRS) merely offer static applications,
in which mostly unstructured text is linked to coded data. In these
applications the more common presentation is a time oriented one,
which does not allow easily for data and information retrieval. Concept
oriented views based on supper-concepts (metaterms) initially defined
in CISMeF to optimize Web medical search, was implemented in our
MRS as specialties views. This work shows that these terminological
tools are able to facilitate information retrieval.
BibTeX:
@inproceedings{Massari2008,
  author = {Massari, P and Pereira, S and Thirion, B and Derville, A and Darmoni, SJ},
  title = {Use of super-concepts to customize electronic medical records data display},
  booktitle = {eHealth Beyond the Horizon - Get IT There - Proceedings of MIE2008 - The XXIst International Congress of the European Federation for Medical Informatics},
  address = {Göteborg, Sweden},
  month = {May},
  year = {2008},
  series = {Studies in Health Technology and Informatics},
  volume = {136},
  pages = {845 - 850},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=8836}
}

Abstract: Objective: The neighbors of a document are those documents in a corpus
that are most similar to it. The objective of this paper is to develop
and evaluate the related resources algorithm (CISMeF-RRA) in the
context of a quality-controlled health gateway on the Internet CISMeF.
Method: CISMeF-RRA is inspired by the PubMed Related Citations Articles.
CISMeF-RRA combines statistical distances with a semantic distance
using MeSH terms/qualifiers. Material: In this feasibility study
an evaluation was performed using 50 CISMeF resources randomly chosen.
Results: Overall, 49% of the related documents were ranked as relevant.
Conclusion: if this feasibility study is confirmed by another evaluation
of more resources, CISMeF-RRA will be implemented in the CISMeF catalog.
BibTeX:
@inproceedings{Tayeb2008a,
  author = {Merabti, T and Pereira, S and Letord, C and Lecroq, T and Dahamna, B and Joubert, M and Darmoni, SJ},
  title = {Searching Related Resources in a Quality Controlled Health Gateway: a Feasibility Study},
  booktitle = {eHealth Beyond the Horizon - Get IT There - Proceedings of MIE2008 - The XXIst International Congress of the European Federation for Medical Informatics},
  address = {Göteborg, Sweden},
  month = {May},
  year = {2008},
  series = {Studies in Health Technology and Informatics},
  volume = {136},
  pages = {235 - 240},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=8729}
}

BibTeX:
@inproceedings{Suzanne2008a,
  author = {Pereira, S and Massari, P and Joubert, M and Serrot, E and Darmoni, SJ},
  title = {Exploring Multi-terminology Indexing of Discharge Summaries},
  month = {May},
  year = {2008},
  note = {(Poster) MIE 2008 eHealth beyond the horizon ? get IT there Göteborg, Sweden May 25-28, 2008}
}

Abstract: Background: In the specific context of French MeSH indexing in an
Internet quality-controlled health gateway, we implemented a MeSH
automatic indexing tool, the French Multi-Terminology Indexer (F-MTI).
It implements a multi-terminology approach using four main medical
terminologies in French and the mappings between them. Objective:
In this paper, we attempt to determine which of lemmatization or
stemming is better to be integrated in F-MTI, and to evaluate an
approach using multi-terminologies. Methods: The algorithm was evaluated
on a CISMeF corpus comprising 18,814 resources indexed manually.
Results: Precision and recall are very close comparing lemmatization
and stemming, and mono-terminology and multi-terminology. Conclusion:
F-MTI will soon be used in the CISMeF production environment and
in a Health MultiTerminology Server in French.
BibTeX:
@inproceedings{Suzanne2008b,
  author = {Pereira, S and Névéol, A and Kerdelhué, G and Serrot, E and Joubert, M and Darmoni, SJ},
  title = {Using multi-terminology indexing for the assignment of MeSH descriptors to health resources in a French online catalogue},
  booktitle = {AMIA symp.},
  publisher = {IOS Press},
  year = {2008},
  pages = {586-590}
}

Abstract: The present work aims at discovering new associations between medical
concepts to be exploited as input in retrieval and indexing. Material
and Methods: Association rules method is applied to documents. The
process is carried out on three major document categories referring
to e-health information consumers: health professionals, students
and lay people. Association rules evaluation is founded on statistical
measures combined with domain knowledge. Results: Association rules
represent existing relations between medical concepts (60.62%) and
new knowledge (54.21%). Based on observations, 463 expert rules are
defined by medical librarians for retrieval and indexing. Conclusions:
Association rules bear out existing relations, produce new knowledge
and support users and indexers in document retrieval and indexing.
BibTeX:
@inproceedings{Soualmia2008,
  author = {Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {Mining knowledge from Corpora: an Application to Retrieval and Indexing},
  booktitle = {eHealth Beyond the Horizon - Get IT There - Proceedings of MIE2008 - The XXIst International Congress of the European Federation for Medical Informatics},
  address = {Göteborg, Sweden},
  month = {May},
  year = {2008},
  series = {Studies in Health Technology and Informatics},
  volume = {136},
  pages = {467-472},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=8769}
}

BibTeX:
@inproceedings{SAKJI2008,
  author = {Sakji, S},
  title = {Recherche multi-terminologique de l'information de santé sur l'Internet.},
  booktitle = {CORIA (cinquième édition de la COnférence en Recherche d'Information et Applications)},
  address = {Tregastel, France},
  month = {Mars},
  year = {2008},
  note = {PSIP},
  url = {http://coria08.irisa.fr}
}

Abstract: Infobuttons are context-specific links between clinical information
systems and other online information resources. The objective of
this study is to describe a French Infobutton, which will be sold
in the Frenchspeaking Health Information market.
BibTeX:
@inproceedings{SJ.2008,
  author = {Darmoni, SJ and Pereira, S and Névéol, A and Massari, P and Dahamna, B and Letord, C and Kedelhué, G and Piot, J and Derville, A and Thirion, B},
  title = {French Infobutton: an academic and... business perspective},
  booktitle = {AMIA Symp.},
  publisher = {IOS Press},
  year = {2008},
  pages = {920}
}

BibTeX:
@inproceedings{Tayeb2008,
  author = {Merabti, T and Pereira, S and Lecroq, T and Joubert, M and Darmoni, SJ},
  title = {Inheritance of SNOMED CT Relations between Concepts by two Health Terminologies (SNOMED International and ICD-10)},
  booktitle = {KR-MED 2008 - Representing and sharing knowledge using SNOMED International Conference},
  address = {Phoenix, AZ, USA},
  month = {June},
  year = {2008},
  note = {InterSTIS}
}

BibTeX:
@inproceedings{Suzanne2008,
  author = {Pereira, Suzanne and Massari, Philippe and Buemi, Antoine and Dahamna, Badisse and Serrot, Elisabeth and and Joubert, Michel and Darmoni, Stéfan J.},
  title = {Evaluation of two French SNOMED indexing systems with a parallel corpus},
  booktitle = {KR-MED 2008 - Representing and sharing knowledge using SNOMED International Conference},
  address = {Phoenix, AZ, USA},
  month = {June},
  year = {2008}
}

2007


Abstract: The UMVF project is a federation of medical teaching resources covering
32 medical schools in France. Today, the indexing of these resources
is carried out manually by the CISMeF team at the University Hospital
of Rouen. This indexing is based on MeSH thesaurus. We use a subset
of SCORM metadata standard. This choice was defined in collaboration
with the French Medical Virtual University consortium (French acronym:
UMVF). Currently, with the UMVF searching tool (called Doc'UMVF),
medical students can reach more than 3300 resources useful in their
curriculum. Doc'UMVF is developed in close collaboration between
the medical informatics laboratories of Rennes and Rouen. In this
paper we present two complementary searching tools based on different
methods and which are integrated and used to improve both the relevance
and the coverage rate of the answers. A specific searching module
has been built to retrieve specific resources concerning the National
Medical Exam ENC ("Examen National Classant") is also available.
Nevertheless, due to lack of time, numerous resources are not yet
indexed. Therefore we have decided to use also automatic indexing
method (Nomindex). This approach will be improved by further research
works, resulting from Rouen and Geneva teams. After having built
a searching meta-motor, our objective is to develop a meta-tool intended
to index the whole set of digital pedagogical resources produced
by the UMVF framework. This manual re-indexing will be carried out
only for the most important resources (national references), with
a more or less fine granularity.
BibTeX:
@article{Cuggia2007,
  author = {Cuggia, M and Darmoni, SJ and Garcelon, N and Soualmia, L and Bourde, A},
  title = {Doc'UMVF: two search tools to provide quality-controlled teaching resources in French to students and teachers.},
  journal = {Int J Med Inform},
  school = {EA3888, UFR 140, University of Rennes, France. marc.cuggia@univ-rennes.fr},
  year = {2007},
  volume = {76},
  number = {5-6},
  pages = {357--362},
  doi = {10.1016/j.ijmedinf.2007.01.001}
}

Abstract: OBJECTIVES: The number of citations an article receives after its
publication not only reflects its impact on the scientific community,
but also the impact of the institutions or countries in the field
studied. In 1987, Garfield introduced the concept of "citation classics"
for the best-cited articles. An analysis of top-cited articles coming
from journals in the field of occupational medicine (eg, Occupational
and Environmental Medicine, Scandinavian Journal of Work, Environment
& Health) has not yet been reported. The purpose of this study was
to assess whether or not such citation classics exist in this field
and to analyze their characteristics. METHODS: The most frequently
cited articles published in the five major journals in occupational
medicine were identified using the database of Science Citation Index
Expanded. The data were obtained by searching one year and one journal
at a time. All of the articles cited more than 100 times were collected
and analyzed. RESULTS: Among the 15 553 articles published by the
five journals since 1949, only 85 articles had been cited more than
100 times. The oldest had been published in 1950 and the latest in
1997. The United Kingdom contributed 28% of the citation classics
and the United States or Sweden produced 19%. The most cited article
had been cited 979 times. The main topics of articles were metabolism,
occupational neoplasms, and work-related musculoskeletal disorders.
CONCLUSIONS: Since the 1980s, Scandinavia and the United States have
taken the leadership in the publication of citation classic papers.
Nevertheless, according to the level of citations, the influence
of literature published in occupational medicine journals remains
limited.
BibTeX:
@article{Gehanno2007,
  author = {Gehanno, JF and Takahashi, K and Darmoni, SJ and Weber, J},
  title = {Citation classics in occupational medicine journals.},
  month = {Aug},
  journal = {Scand J Work Environ Health},
  school = {Institute of Occupational Health, Rouen University Hospital, 1 rue de Germont, 76000 Rouen cedix, France. jean-francois.gehanno@chu-rouen.fr},
  year = {2007},
  volume = {33},
  number = {4},
  pages = {245--251}
}

BibTeX:
@article{Gehanno2007b,
  author = {Gehanno, JF and Vu, T and Choudat, D and Conso, F},
  title = {Devenir des internes de medecine du travail formes en France entre 2002 et 2004},
  month = {April},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2007},
  volume = {68},
  pages = {110-118},
  url = {http://www.sciencedirect.com/science/article/B8JFG-4R0CFRC-2/2/ce5acd7798f06412549571cc53f5a9e1},
  doi = {10.1016/S1775-8785(07)88908-9}
}

Abstract: OBJECTIVES: The aim of the study was to evaluate urinary mutagenicity
in workers employed in a major chemical plant located near Rouen
(France) that produces dichlorobenzidine and azo dyes. MATERIALS
AND METHODS: Samples were obtained from 47 male workers aged 38.9+/-11.3
years (range, 21-58 years), mean duration of employment 9.0+/-8.7
years (range, 1-32 years) for urinary mutagenicity determination
with use of the Ames fluctuation test (strains TA 98 and TA 100 with
and without metabolic activation) and gas chromatography/mass spectrometry.
To assess occupational exposure of workers, urine samples were collected
in two series. First, initial just after a one-month holiday (non-exposure).
Second, four months later during regular occupational activity. During
the same periods, workers completed a questionnaire, which sought
information concerning their working conditions, non-occupational
factors, and personal habits. RESULTS: Of the total 47 samples tested,
3 (6 collected just after a one-month holiday and 6 (12 samples
collected during regular occupational activity were positive in at
least one mutagenicity assay. Dichlorobenzidine traces ranging from
1.6 to 8.9 ppb were detected in 4 (8 samples of the exposed as
well as in 4 (8 samples of non-exposed workers. No significant
differences between biological and analytical responses obtained
in the non-exposure period and after occupational exposure were observed,
however, 5 (11 workers in this group presented urinary mutagenicity
that could be related to occupational exposure. CONCLUSIONS: The
study suggests that some industrial hygiene problems, revealed in
the analysis of questionnaire responses and confirmed by our evaluation,
could be undoubtedly and easily solved to improve working conditions
of the employees.
BibTeX:
@article{Guerbet2007,
  author = {Guerbet, Michel and Brisorgueuil, Emilie and Jolibois, Boris and Caillard, Jean-Francois and Gehanno, Jean-Francois},
  title = {Evaluation of urinary mutagenicity in azo dye manufacture workers.},
  journal = {International journal of occupational medicine and environmental health},
  year = {2007},
  volume = {20},
  number = {2},
  pages = {137--145},
  doi = {10.2478/v10001-007-0014-4}
}

Abstract: The " Université Médicale Virtuelle Francophone" (UMVF) is a federation
of French medical schools. Its main goal is to share the production
and use of pedagogic medical resources generated by academic medical
teachers. We developed an Open-Source application based upon a workflow
system, which provides an improved publication process for the UMVF.
For teachers, the tool permits easy and efficient upload of new educational
resources. For web masters it provides a mechanism to easily locate
and validate the resources. For librarian it provide a way to improve
the efficiency of indexation. For all, the utility provides a workflow
system to control the publication process. On the students side,
the application improves the value of the UMVF repository by facilitating
the publication of new resources and by providing an easy way to
find a detailed description of a resource and to check any resource
from the UMVF to ascertain its quality and integrity, even if the
resource is an old deprecated version. The server tier of the application
is used to implement the main workflow functionalities and is deployed
on certified UMVF servers using the PHP language, an LDAP directory
and an SQL database. The client tier of the application provides
both the workflow and the search and check functionalities. A unique
signature for each resource, was needed to provide security functionality
and is implemented using a Digest algorithm. The testing performed
by Rennes and Lille verified the functionality and conformity with
our specifications.
BibTeX:
@article{Renard2007,
  author = {Renard, JM and Bourde, A and Cuggia, M and Garcelon, N and Souf, N and Darmoni, SJ and Beuscart, R and Brunetaud, JM},
  title = {An Internet supported workflow for the publication process in UMVF (French Virtual Medical University).},
  journal = {Int J Med Inform},
  school = {CERIM, Faculté de Médecine, Université Lille 2, France. jean-marie.renard@univ-lille2.fr},
  year = {2007},
  volume = {76},
  number = {5-6},
  pages = {363--368},
  doi = {10.1016/j.ijmedinf.2007.01.010}
}

BibTeX:
@article{Kerdelhue2007,
  author = {Kerdelhué, G},
  title = {Utilisation du thésaurus MeSH dans le site CISMeF.},
  journal = {Documentaliste - Sciences de l'information},
  year = {2007},
  volume = {44},
  number = {1},
  url = {http://www.adbs.fr/utilisation-du-thesaurus-mesh-dans-le-site-cismef-15472.htm}
}

BibTeX:
@phdthesis{Florea2007c,
  author = {Florea, F},
  title = {Indexation et recherche d'information combinée texte et image dans le catalogue de santé CISMeF},
  school = {INSA de Rouen},
  year = {2007}
}

BibTeX:
@inproceedings{SJ.2007,
  author = {Darmoni, SJ},
  title = {Information and Communication Technologies in Modern Health Library.},
  booktitle = {EAHIL Workshop},
  address = {Cracovie, Pologne},
  month = {September},
  year = {2007},
  url = {http://www.bm.cm-uj.krakow.pl/eahil/proceedings/oral/Darmoni.pdf}
}

BibTeX:
@inproceedings{Florea2007,
  author = {Florea, F and Buzuloiu, V and Rogozan, A and Bensrhair, A and Darmoni, SJ},
  title = {Automatic Image Annotation Combining the Content and the Context of Medical Images},
  booktitle = {Proc. International Symposium on Signals, Circuits and Systems ISSCS 2007},
  year = {2007},
  volume = {1},
  pages = {1--4},
  doi = {10.1109/ISSCS.2007.4292712}
}

BibTeX:
@inproceedings{Florea2007a,
  author = {Florea, F and Rogozan, A and Barbu, E and Bensrhair, A and Darmoni, SJ},
  title = {MedIC at ImageCLEF 2006: Automatic Image Categorization and Annotation using Combined Visual Representations},
  address = {Alicante, Spain},
  journal = {Lecture Notes in Computer Science},
  year = {2007},
  number = {4730},
  pages = {670-677},
  url = {http://www.springerlink.com/content/w4832362m341/?k=florea},
  doi = {10.1007/978-3-540-74999-8_82}
}

Abstract: Background: CISMeF is a French quality-controlled health gateway that
uses the MeSH thesaurus. We introduced two new concepts, metaterms
(medical specialty which has semantic links with one or more MeSH
terms, subheadings and resource types) and resource types. Objective:
evaluate precision and recall of metaterms. Methods: We created 16
pairs of queries. Each pair concerned the same topic, but one used
metaterms and one MeSH terms. To assess precision, each document
retrieved by the query was classified as irrelevant, partly relevant
or fully relevant. Results: the 16 queries yielded 943 documents
for metaterm queries and 139 for MeSH term queries. The recall of
MeSH term queries was 0.44 (compared to 1 for metaterm queries) and
the precision were identical for MeSH term and metaterm queries.
Conclusion: Metaconcept such as CISMeF metaterms allows a better
recall with a similar precision that MeSH terms in a quality controlled
health gateway.
BibTeX:
@inproceedings{Gehanno2007a,
  author = {Gehanno, JF and Thirion, B and Darmoni, SJ},
  title = {Evaluation of Meta-concepts for Information Retrieval in a Quality-Controlled Health Gateway.},
  booktitle = {AMIA Symp.},
  publisher = {IOS Press},
  year = {2007},
  pages = {269-73},
  url = {http://telemedicina.unifesp.br/pub/AMIA/2007%20AMIA%20Proceedings/data/papers/papers/AMIA-0085-S2007.pdf}
}

Abstract: This article presents the Cogni-CISMeF project, which aims at improving
medical information search in the CISMeF system by including a conversational
agent to interact with the user in natural language. To study the
cognitive processes involved during the information search, a bottom-up
methodology was adopted. Experiments have been set up to obtain human
dialogs dealing with medical information search. The analysis of
these dialogs underlined the establishment of a common ground and
accommodation effects to the user. A model of artificial agent is
proposed. It leads the user in its information search by proposing
to him examples, assistance and choices.
BibTeX:
@inproceedings{Loisel2007,
  author = {Loisel, A. and Chaignaud, N. and Kotowicz, J-Ph.},
  title = {Designing a Human-Computer Dialog System for Medical Information Search},
  booktitle = {Proc. IEEE/WIC/ACM International Conferences on Web Intelligence and Intelligent Agent Technology Workshops},
  year = {2007},
  pages = {350--353},
  doi = {10.1109/WIIATW.2007.4427605}
}

Abstract: Background: The growing number of resources to be indexed in the catalogue
of online health resources in French (CISMeF) calls for curating
strategies involving automatic indexing tools while maintaining the
catalogue's high indexing quality standards. Objective: To develop
a simple automatic tool that retrieves MeSH descriptors from documents
titles. Methods: In parallel to research on advanced indexing methods,
a bag-of-words tool was developed for timely inclusion in CISMeF's
maintenance system. An evaluation was carried out on a corpus of
99 documents. The indexing sets retrieved by the automatic tool were
compared to manual indexing based on the title and on the full text
of resources. Results: 58% of the major main headings were retrieved
by the bag-of-words algorithm and the precision on main heading retrieval
was 69%. Conclusion: Bag-of-words indexing has effectively been used
on selected resources to be included in CISMeF since August 2006.
Meanwhile, on going work aims at improving the current version of
the tool.
BibTeX:
@article{Neveol2007,
  author = {Névéol, A. and Pereira, S. and Kerdelhué, G. and Dahamna, B. and Joubert, M. and Darmoni, SJ},
  title = {Evaluation of a Simple Method for the Automatic Assignment of MeSH Descriptors to Health Resources in a French Online Catalogue.},
  address = {U.S. National Library of Medicine, National Institutes of Health, Bethesda, USA.},
  journal = {Stud Health Technol Inform},
  year = {2007},
  volume = {129},
  pages = {407--411}
}

Abstract: The catalog of online medical resources in French (CISMeF) is a quality
controlled health gateway selecting and describing major institutional
medical resources in French. In order to update the catalog in a
timely fashion, research efforts have addressed the development of
automatic tools to process resources selected for inclusion in the
catalogue. The result of the automatic processing, namely a description
of resources in the form of MeSH descriptors, may be reviewed by
CISMeF indexers before inclusion in the catalogue. After a brief
introduction to CISMeF and the task of MeSH indexing, we review the
reasons that led to chose NooJ as a text analysis tool and describe
how it was integrated in a MeSH indexing system (MAIF). On-going
work focuses on further development of medical text analysis material
(NooJ dictionary and transducers) for MeSH indexing, to be eventually
extended to multi-terminological indexing and Summary of Product
Characteristics (SPC) analysis. NOOJ applications for other terminology
such as ICD-10, SNOMED international, CCAM (French equivalent of
US CPT) and TUV (French terminology for therapeutical and clinical
notions for the use of drugs) will therefore be studied.
BibTeX:
@inproceedings{Neveol2007b,
  author = {Névéol, Aurélie and Pereira, Suzanne and Lortal, Gaëlle and Darmoni, Stéfan},
  title = {Using NooJ for analyzing medical texts in French},
  booktitle = {NOOJ Conference},
  address = {Barcelona, Spain},
  month = {june},
  year = {2007},
  url = {http://vodel.insa-rouen.fr/publications/cismef-nooj2007/}
}

Abstract: The number of articles in the MEDLINE database is expected to increase
tremendously in the coming years. To ensure that all these documents
are indexed with continuing high quality, it is necessary to develop
tools and methods that help the indexers in their daily task. We
present three methods addressing a novel aspect of automatic indexing
of the biomedical literature, namely producing MeSH main heading/subheading
pair recommendations. The methods, (dictionary-based, post- processing
rules and Natural Language Processing rules) are described and evaluated
on a genetics-related corpus. The best overall performance is obtained
for the subheading genetics (70% precision and 17% recall with
post-processing rules, 48% precision and 37% recall with the dictionary-based
method). Future work will address extending this work to all MeSH
subheadings and a more thorough study of method combination.
BibTeX:
@inproceedings{Neveol2007a,
  author = {Névéol, A and Shooshan, S and Humphrey, S and Rindflesh, T and Aronson, AR},
  title = {Multiple approaches to fine-grained indexing of the biomedical literature.},
  journal = {Pac Symp Biocomput},
  school = {National Library of Medicine, NIH, Bethesda, MD 20894, USA.},
  year = {2007},
  pages = {292--303},
  url = {http://psb.stanford.edu/psb-online/proceedings/psb07/neveol.pdf}
}

Abstract: The present work aims at refining and expanding user?s queries thanks
to association rules. We adapted the A-Close algorithm to a medical
corpus indexed by MeSH descriptors. The originality of our approach
lies in the use of the association rules in the information retrieval
process and the exploitation of the structure of the domain knowledge
to evaluate the association rules. The results show the usefulness
of this query expansion approach. Based on observations, new knowledge
is modelled as expert rules.
BibTeX:
@inproceedings{Soualmia2007,
  author = {Soualmia, L and Dahamna, B},
  title = {Knowledge Acquisition from a Medical Corpus: Use and Return on Experiences},
  booktitle = {Artificial Intelligence in Medicine},
  journal = {Artificial Intelligence in Medicine},
  publisher = {Springer Berlin / Heidelberg},
  year = {2007},
  series = {Lecture Notes in Computer Science},
  volume = {4594},
  pages = {160-164},
  url = {http://www.springerlink.com/index/j165732mqm231012.pdf},
  doi = {10.1007/978-3-540-73599-1\_19}
}

Abstract: L'objectif est de couvrir le maximun des cours concernant la recherche
documentaire par une mutualisation de ces cours. Expérience de Rouen.
BibTeX:
@inproceedings{Darmoni2007a,
  author = {Darmoni, SJ},
  title = {Recherche documentaire},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Strasbourg, France},
  month = {Octobre},
  year = {2007},
  url = {http://www.canal-u.fr/index.php/canalu/producteurs/canal_u_medecine/dossier_programmes/pedagogie_des_sciences_medicales/colloque_et_evenement/internet_et_pedagogie_medicale_strasbourg_2007/ipm_2007}
}

BibTeX:
@inproceedings{Florea2007b,
  author = {Florea, F and Cornea, V and Rogozan, A and Bensrhair, A and Darmoni, SJ},
  title = {Fusion des approches visuelles et contextuelles pour l'annotation des images m{\'e}dicales},
  booktitle = {Extraction et Gestion des Connaissances (EGC)},
  address = {Namur, Belgique},
  month = {23-26 Janvier},
  year = {2007},
  volume = {2},
  pages = {421-426}
}

BibTeX:
@inproceedings{Kotowicz2007,
  author = {Kotowicz, JP. and Chaignaud, N. and Pecuchet, JP. and Loisel, A and Holzem, M. and Delavigne, V. and Darmoni, SJ.},
  title = {Cogni-CISMeF : étude des processus cognitifs lors de la construction d'une requête dans un syste?me de gestion des connaissances me?dicales (CISMeF)},
  booktitle = {Atelier Traitement des Connaissances, Apprentissage et NTIC, Plate-forme AFIA'07},
  address = {Grenoble},
  month = {2-6 juillet},
  year = {2007},
  pages = {155-174}
}

BibTeX:
@inproceedings{Pereira2007,
  author = {Pereira, S and Massari, P and Joubert, M and Darmoni, SJ},
  title = {Utilisation de métatermes pour la recherche d'information dans les dossiers médicaux.},
  booktitle = {JFIM},
  address = {Bamako, Mali},
  month = {Janvier},
  year = {2007}
}

Abstract: Introduction: Physicians are expected to prescribe according to current
scientific data and evidence-based medicine, as embodied by official
treatment guidelines. In order to apply these, physicians should
be aware of ways to access them, and smoothly integrate their content
into their daily practice. Our objectives were to provide validated
summaries of treatment guidelines, to facilitate access to original
documents, and to keep physicians informed on updates and related
news. Methods: For one hundred most frequently encountered diseases,
expert writers (GPs and specialists) were chosen to produce a summary
of current validated treatment guidelines. The outline and content
of these summaries were harmonized in order to increase user-friendliness.
Tree-shaped decision algorithms constitute the core of each summary.
They are completed with disease and diagnosis information, specific
clinical situations, patient information as well as drug and non
drug treatment information (all available medicinal products are
listed). Whenever possible, these summaries are weighed with grades
of recommendation corresponding to scientific levels of evidence,
as defined by the HAS (high autority of health). Results: The therapeutic
guidelines database is available through: - a website which proposes
therapeutic guidelines summaries and related information regarding
diseases most frequently encountered by GPs. A search engine has
been integrated, which allows physicians to locate French and international
treatment guidelines. This engine transforms queries expressed in
usual French medical terms into MeSH (medical subjects headings)
- compatible queries in order to search French and international
databases efficaciously. We created a watch team to update the database
and inform physicians about the latest available guidelines as well
as other recent guidelinerelated news. - a pocket book with one hundred
treatment strategies based on guideline summaries. Conclusion: The
therapeutic guidelines database is the first one for Frenchspeaking
healthcare professionals. It allows access to validated therapeutic
guidelines (summaries, full-text guidelines, as well as related news).
The next step is to measure the effects of this new tool on GPs daily
practice.
BibTeX:
@article{C2007,
  author = {Caulin, C and Autret-Leca, E and Baumelou, A and Trémolières, F and German, C and Darmoni, SJ and Thirion B and Forget, JF},
  title = {The therapeutic guidelines database, an original new tool},
  journal = {Fundamental \& Clinical Pharmacology},
  year = {2007},
  volume = {21},
  number = {s1},
  pages = {1-99},
  doi = {10.1111/j.1472-8206.2007.00481.x}
}

BibTeX:
@inproceedings{Darmoni2007,
  author = {Darmoni, SJ and Thirion, B and Florea, F and Rogozan, A and Letord, C and Kerdelhué, G and Dacher, JN},
  title = {Affiliation of a resource type to a MeSH term in a quality-controlled health gateway},
  booktitle = {Medinfo},
  year = {2007},
  url = {http://www.chu-rouen.fr/l@stics/affiliation_medinfo_2007.pdf}
}

Abstract: When searching the medical literature, health professionals and lay
people strongly prefer to use their native language. Therefore, Medical
Subject Headings (MeSH(R)) translations would be helpful to those
who are not fluent in English to access scientific papers indexed
in the MEDLINE(R) bibliographic database. Furthermore, medical terminologies
such as MeSH are challenging in any language. Therefore, a French
MeSH Browser was developed.
BibTeX:
@inproceedings{Benoit2007,
  author = {Thirion, B and Pereira, S and Névéol, A and Dahamna, B and Darmoni, SJ.},
  title = {French MeSH Browser: a cross-language tool to access MEDLINE/PubMed.},
  booktitle = {AMIA symp.},
  publisher = {IOS Press},
  year = {2007},
  pages = {1132},
  url = {http://telemedicina.unifesp.br/pub/AMIA/2007%20AMIA%20Proceedings/data/papers/posters/AMIA-0243-S2007.pdf}
}

2006


Abstract: BACKGROUND: Categorization is designed to enhance resource description
by organizing content description so as to enable the reader to grasp
quickly and easily what are the main topics discussed in it. The
objective of this work is to propose a categorization algorithm to
classify a set of scientific articles indexed with the MeSH thesaurus,
and in particular those of the MEDLINE bibliographic database. In
a large bibliographic database such as MEDLINE, finding materials
of particular interest to a specialty group, or relevant to a particular
audience, can be difficult. The categorization refines the retrieval
of indexed material. In the CISMeF terminology, metaterms can be
considered as super-concepts. They were primarily conceived to improve
recall in the CISMeF quality-controlled health gateway. METHODS:
The MEDLINE categorization algorithm (MCA) is based on semantic links
existing between MeSH terms and metaterms on the one hand and between
MeSH subheadings and metaterms on the other hand. These links are
used to automatically infer a list of metaterms from any MeSH term/subheading
indexing. Medical librarians manually select the semantic links.
RESULTS: The MEDLINE categorization algorithm lists the medical specialties
relevant to a MEDLINE file by decreasing order of their importance.
The MEDLINE categorization algorithm is available on a Web site.
It can run on any MEDLINE file in a batch mode. As an example, the
top 3 medical specialties for the set of 60 articles published in
BioMed Central Medical Informatics & Decision Making, which are currently
indexed in MEDLINE are: information science, organization and administration
and medical informatics. CONCLUSION: We have presented a MEDLINE
categorization algorithm in order to classify the medical specialties
addressed in any MEDLINE file in the form of a ranked list of relevant
specialties. The categorization method introduced in this paper is
based on the manual indexing of resources with MeSH (terms/subheadings)
pairs by NLM indexers. This algorithm may be used as a new bibliometric
tool.
BibTeX:
@article{Darmoni2006,
  author = {Darmoni, SJ and Névéol, A and Renard, JM and Gehanno, JF and Soualmia, L and Dahamna, B and Thirion, B},
  title = {A MEDLINE categorization algorithm.},
  journal = {BMC Med Inform Decis Mak},
  school = {CISMeF, Rouen University Hospital, 76031 Rouen, France. stefan.darmoni@chu-rouen.fr},
  year = {2006},
  volume = {6},
  pages = {7},
  doi = {10.1186/1472-6947-6-7}
}

Abstract: The profusion of online resources calls for tools and methods to help
Internet users find precisely what they are looking for. Quality
controlled gateway CISMeF provides such services for health resources.
However, the human cost of maintaining and updating the catalogue
are increasingly high. This paper presents the automatic indexing
system currently developed in the CISMeF team to be used as such
for preliminary indexing, or after human reviewing for the final
indexing. The system architecture, using the INTEX platform for MeSH
term extraction is detailed. The results of a first evaluation tend
to indicate that the automatic indexing strategy is relevant, as
it achieves a precision comparable to that of other existing operational
systems. Moreover, the system presented in this paper retrieves keyword/qualifier
pairs as opposed to single terms, therefore providing a significantly
more precise indexing. Further development and tests will be carried
out in order to improve the coverage of the dictionaries, and validate
the efficiency of the system in the indexers' everyday work.
BibTeX:
@article{Neveol2006b,
  author = {Névéol, A and Rogozan, Aé and Darmoni, SJ},
  title = {Automatic indexing of online health resources for a French quality controlled gateway},
  month = {May},
  journal = {Information Processing \& Management},
  year = {2006},
  volume = {42},
  number = {3},
  pages = {695-709},
  doi = {10.1016/j.ipm.2005.01.003}
}

Abstract: OBJECTIVES: The paper (1) introduces health sciences librarians to
the main concepts and principles of the Semantic Web (SW) and (2)
briefly reviews a number of projects on the handling of biomedical
information that uses SW technology. METHODOLOGY: The paper is structured
into two main parts. "Semantic Web Technology" provides a high-level
description, with examples, of the main standards and concepts: extensible
markup language (XML), Resource Description Framework (RDF), RDF
Schema (RDFS), ontologies, and their utility in information retrieval,
concluding with mention of more advanced SW languages and their characteristics.
"Semantic Web Applications and Research Projects in the Biomedical
Field" is a brief review of the Unified Medical Language System (UMLS),
Generalised Architecture for Languages, Encyclopedias and Nomenclatures
in Medicine (GALEN), HealthCyberMap, LinkBase, and the thesaurus
of the National Cancer Institute (NCI). The paper also mentions other
benefits and by-products of the SW, citing projects related to them.
DISCUSSION AND CONCLUSIONS: Some of the problems facing the SW vision
are presented, especially the ways in which the librarians' expertise
in organizing knowledge and in structuring information may contribute
to SW projects.
BibTeX:
@article{Robu2006,
  author = {Robu, I and Robu, V and Thirion, B},
  title = {An introduction to the Semantic Web for health sciences librarians.},
  month = {Apr},
  journal = {J Med Libr Assoc},
  school = {University of Medicine and Pharmacy, Central Library, Str. Avram Iancu 31 400083, Cluj-Napoca, Romania. irobu@umfcluj.ro},
  year = {2006},
  volume = {94},
  number = {2},
  pages = {198--205},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1435839}
}

Abstract: The faculty to student (F/S) ratio is a key criterion in ranking medical
universities. In France, the registration of students at the medical
university in their home region is mandatory. At the end of undergraduate
studies, students have to take the National Ranking Exam (NRE), and
choice of specialty is based on their rank. The purpose of this study
was to investigate the relation between teaching faculty resources
in medical universities and the ranking of students on the NRE. All
32 public medical universities with a complete curriculum were included.
Correlation of the 2003-2004 F/S ratio with the mean rank of students
at the 2004 NRE was assessed using Spearman's rank correlation coefficient
[r(s)]. The overall university F/S ratios ranged from 1.16 to 2.62
overall, and from 0.68 to 1.63 and 0.47 to 1.08 for tenured and non-tenured
positions, respectively. All were significantly correlated with mean
rank at the NRE (r(s) = -0.53, r(s) = -0.50, r(s) = -0.52, respectively,
all p textless 0.01). As this link between teaching means and
students' performance has consequences in the competition for career
choice, large disparities among medical universities are not legitimate
in a regulated model. Deregulation of regional applications should
be considered to come close to equality of opportunity.
BibTeX:
@article{Roussel2006,
  author = {Roussel, Francis and Gehanno, Jean-Francois and Ladner, Joel and Benichou, Jacques},
  title = {Do teaching faculty resources affect the choice of medical career?},
  month = {December},
  journal = {Medical teacher},
  year = {2006},
  volume = {28},
  number = {8},
  pages = {734--741},
  doi = {10.1080/01421590601047664}
}

Abstract: BACKGROUND: The Script Concordance test (SC) test is an assessment
tool that measures the capacity to solve ill-defined problems, that
is, reasoning in a context of uncertainty. This study assesses the
feasibility, reliability and validity of the SC test made available
on the Web to French urologists. METHODS: A 97 items SC test was
developed based on major educational objectives of French urology
training programmes. A secure Web site was created with two sequential
modules: a) The first one for the reference panel to elaborate the
scoring system; b) The second for candidates with different levels
of experience in urology: Board certified urologists, chief-residents,
residents, medical students. All participants were recruited on a
voluntary basis. Statistical analysis included descriptive statistics
of the participants' scores and factorial analysis of variance (ANOVA)
to study differences between groups' means. Reliability was evaluated
with Cronbach's alpha coefficient. RESULTS: The on line SC test has
been operational since June 2004. Twenty-six faculty members constituted
the reference panel. During the following 10 months, 207 participants
took the test online (124 urologists, 29 chief-residents, 38 residents,
16 students). No technical problem was encountered. Forty-five percent
of the participants completed the test partially only. Differences
between the means scores for the 4 groups were statistically significant
(P = 0.0123). The Bonferroni post-hoc correction indicated that significant
differences were present between students and chief-residents, between
students and urologists. There were no differences between chief-residents
and urologists. Reliability coefficient was 0.734 for the total group
of participants. CONCLUSION: Feasibility of Web-based SC test was
proved successful by the large number of participants who participated
in a few months. This Web site has permitted to quickly confirm reliability
of the SC test and develop strategy to improve construct validity
of the test when applied in the field of urology. Nevertheless, optimisation
of the SC test content, with a smaller number of items will be necessary.
Virtual medical education initiative such as this SC test delivered
on the Internet warrants consideration in the current context of
national pre-residency certification examination in France.
BibTeX:
@article{Sibert2006a,
  author = {Sibert, L and Darmoni, SJ and Dahamna, B and Hellot, MF and Weber, J and Charlin, B},
  title = {On line clinical reasoning assessment with Script Concordance test in urology: results of a French pilot study.},
  journal = {BMC Med Educ},
  school = {Department of Urology, Rouen University Hospital, 1, rue de Germont 76031 Rouen Cedex, France. louis.sibert@chu-rouen.fr},
  year = {2006},
  volume = {6},
  pages = {45},
  doi = {10.1186/1472-6920-6-45}
}

Abstract: Access to accurate and quality-controlled health information on the
Internet for medical students is not an easy task. CISMeF is the
search tool of a MeSH-indexed directory of medical Internet resources
in French. Since 2004, a new French Pre-Residency Examination (PRE)
is compulsory for all medical students in the 6th year of the curriculum.
The goal of this study is to evaluate CISMeF as a tool to provide
teaching resources available on the Internet covering PRE material.
The CISMeF terminology and the PRE CISMeF module are described. To
assess the CISMeF performance in covering PRE program, its precision
(number of relevant resources/number of overall resources extracted
by CISMeF) and coverage (number of PRE questions covered by at least
one resource in the CISMeF gateway) were computed. The CISMeF module
for the new French Pre-Residency Examination is efficient as it already
covers 95.7% of the program with a precision of 82.2%. Our data
demonstrates that CISMeF is acceptable to guide students' learning
and should be a useful teaching resource for the preparation of the
French Pre-Residency Examination.
BibTeX:
@article{Sibert2006,
  author = {Sibert, L and Darmoni, SJ and Thirion, B and Douyère, M and Dahamna, B and Weber, J},
  title = {A web-based teaching resource to prepare for final undergraduate examination: a French pilot study.},
  month = {Mar},
  journal = {Med Teach},
  school = {Department of Medical Education, Rouen Medical School, France. louis.sibert@chu-rouen.fr},
  year = {2006},
  volume = {28},
  number = {2},
  pages = {158--164},
  doi = {10.1080/01421590500312920}
}

BibTeX:
@article{Broessel2006,
  author = {Broessel, N. and Ponsin, S. and Tardif, C. and Rollin, L. and Paris, C.},
  title = {Retentissement professionnel du {SAS} : une étude cas témoins},
  journal = {Revue des maladies respiratoires},
  year = {2006},
  volume = {23},
  pages = {97--97},
  doi = {10.1016/S0761-8425(06)72368-3}
}

BibTeX:
@article{Gehanno2006e,
  author = {Gehanno, J.F. and Abitboul, D.A.},
  title = {Quelle est la place du médecin du travail dans la prévention des infections nosocomiales ?},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2006},
  volume = {67},
  number = {4},
  pages = {603--606},
  doi = {10.1016/S1775-8785(06)70438-6}
}

BibTeX:
@article{Gehanno2006,
  author = {Gehanno, JF and Kerdelhué, G and Darmoni, SJ and Fantoni, S and Caillard, JF and Frimat, P},
  title = {Veille documentaire},
  month = {May},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2006},
  volume = {67},
  pages = {266-267},
  url = {http://www.sciencedirect.com/science/article/B8JFG-4PR42F2-5G/2/1968f7b5e0022da180878cb2a4d3f887},
  doi = {10.1016/S1775-8785(06)78134-6}
}

Abstract: A 52-year-old woman physician developed recurrent erythema multiforme.
Occupational and environmental exposure assessment suggested a disinfectant
containing polyhexamethylenebiguanide hydrochloride (PHMB), Phagosept.
Elimination of the product was followed by disappearance of symptomatology.
Literature search revealed cases of sensitization and anaphylaxis
due to contact with PHMB, but to our knowledge, this is the first
report on PHMB-induced erythema multiforme.
BibTeX:
@article{Gehanno2006c,
  author = {Gehanno, Jean-Francois and Priot, Anne-Emmanuelle and Balguerie, Xavier and Caillard, Jean-Francois},
  title = {Polyhexamethylenebiguanide hydrochloride exposure and erythema multiforme in a physician.},
  journal = {International journal of occupational medicine and environmental health},
  year = {2006},
  volume = {19},
  number = {1},
  pages = {81--82}
}

BibTeX:
@article{Gehanno2006d,
  author = {Gehanno, J.-F. and Sobaszek, A. and Touche, S. and Ripault, B. and Caillard, J.-F. and Paris, C. and Hartemann, P.},
  title = {Risques biologiques},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2006},
  volume = {67},
  number = {2},
  pages = {263--264},
  doi = {10.1016/S1775-8785(06)78131-0}
}

BibTeX:
@inproceedings{Neveol2006c,
  author = {Névéol, A and Darmoni, SJ},
  title = {Terminologie et accès à l'information en santé.},
  booktitle = {Terminologie et accès à l'information},
  month = {October},
  publisher = {Hermes Science Publications},
  year = {2006},
  pages = {141-159},
  url = {http://www.lavoisier.fr/fr/livres/index.asp?texte=2746212950&select=isbn&from=Hermes}
}

BibTeX:
@article{Paris2006,
  author = {Paris, C and Gehanno, JF},
  title = {Les apports de l'Evidence Based Medicine dans les pratiques de surveillance du médecin du travail.},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2006},
  volume = {67},
  number = {2},
  pages = {154-7},
  doi = {ADMP-05-2006-67-2-1250-3274-101019-200517911}
}

BibTeX:
@inproceedings{Florea2006,
  author = {Florea, F and Barbu, E and Rogozan, A and Bensrhair, A},
  title = {Using texture-based symbolic features for medical image representation},
  booktitle = {Proc. 18th International Conference on Pattern Recognition ICPR 2006},
  year = {2006},
  volume = {2},
  pages = {946--949},
  doi = {10.1109/ICPR.2006.1159}
}

BibTeX:
@inproceedings{Florea2006f,
  author = {Florea, F and Barbu, E and Rogozan, A and Bensrhair, A},
  title = {Multi-modal categorization of medical images for automatic indexing of on-line health-resources},
  booktitle = {6th International Workshop on Pattern Recognition in Information Systems (PRIS2006)},
  address = {Paphos, Cyprus},
  month = {23 - 27, May 2006},
  year = {2006},
  pages = {48-57}
}

BibTeX:
@inproceedings{Florea2006a,
  author = {Florea, F and Barbu, E and Rogozan, A and Bensrhair, A and Buzuloiu, V},
  title = {Medical Image Categorization using a Texture Based Symbolic Description},
  booktitle = {Proc. IEEE International Conference on Image Processing},
  year = {2006},
  pages = {1489--1492},
  doi = {10.1109/ICIP.2006.312564}
}

BibTeX:
@inproceedings{Florea2006h,
  author = {Florea, F and Rogozan, A and Bensrhair, A and Darmoni, SJ},
  title = {Comparison of Feature-Selection and Classification Techniques for Medical Image Modality Categorization},
  booktitle = {10th IEEE International Conference on Optimization of Electrical and Electronic Equipment (OPTIM2006)},
  address = {Brasov, Romania},
  month = {May 18-19},
  year = {2006},
  volume = {4},
  pages = {161-168},
  url = {http://asi.insa-rouen.fr/~fflorea/documents/rapport_intern_PSI_FFI.pdf}
}

BibTeX:
@inproceedings{Florea2006g,
  author = {Florea, F and Rogozan, A and Cornea, V and Bensrhair, A and Darmoni, SJ},
  title = {MedIC/CISMeF at ImageCLEF 2006: Image Annotation and Retrieval Tasks},
  booktitle = {CLEF 2006 Workshop},
  address = {Alicante, Spain},
  month = {20 - 22 September},
  year = {2006},
  url = {http://www.clef-campaign.org/2006/working_notes/workingnotes2006/floreaCLEF2006.pdf}
}

BibTeX:
@inproceedings{Gehanno2006b,
  author = {Gehanno, JF and Darmoni, SJ and Weber, J and Caillard, JF},
  title = {Citation classics in occupational medicine journals.},
  booktitle = {28th Congress of the International Commission of Occupational Health},
  address = {Milan, Italy},
  month = {June},
  year = {2006}
}

Abstract: OBJECTIVES: to improve the indexing of French-language health web
sites by emphasizing the major terms that best describe them. MATERIAL
AND METHODS: this study exploits both UMLS knowledge sources and
results of previous research. It proposes a method for ranking MeSH
terms taken from each record in order of relevance. The method is
tested on a corpus of records taken from the French-language health
gateway CISMeF. RESULTS: the results of the experiment are compared
to those of a preliminary study performed on a corpus taken from
MEDLINE. DISCUSSION: the ultimate objective of this work is to interface
the developed tools with an automated MeSH term extractor in order
to propose an automated indexing engine for French-language health
web sites.
BibTeX:
@article{Joubert2006,
  author = {Joubert, M and Peretti, AL and Darmoni, SJ and Dahamna, B and Fieschi,M},
  title = {Contribution to an automated indexing of French-language health web sites.},
  journal = {AMIA Annu Symp Proc},
  school = {LERTIM, Faculté de Médecine, Université de la Méditerranée, Marseille, France.},
  year = {2006},
  pages = {409--413},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1839524}
}

Abstract: OBJECTIVES: This paper presents a method of cross-language information
retrieval aiming to make medical information available to patients
in French and English, regardless of the query language they wish
to use. METHODS: We describe the two MeSH-related terminologies used
in this work. We show that the French patient synonyms included in
CISMeF can be automatically mapped to the English consumer-oriented
health topics used in MEDLINEplus, via the MeSH thesaurus. The links
between French and English patient terms thus inferred can subsequently
be exploited to automatically translate patient queries. RESULTS:
129 MEDLINEplus topics have been mapped to 142 CISMeF patient synonyms.
Contextual links for cross-language retrieval have been added to
the patient dedicated French information Gateway CISMeF. Conclusion:
we have presented an efficient method for cross-lingual patient information
retrieval in French and English, which may also be applied to other
language pairs, subject to the availability of patient terminologies
and of the MeSH thesaurus in these languages.
BibTeX:
@article{Neveol2006,
  author = {Névéol, A and Pereira, S and Soualmia, L and Thirion, B and Darmoni, SJ},
  title = {A method of cross-lingual consumer health information retrieval.},
  journal = {Stud Health Technol Inform},
  school = {Université de Rouen, France.},
  year = {2006},
  volume = {124},
  pages = {601--608}
}

Abstract: OBJECTIVE: This paper explores alternative approaches for the evaluation
of an automatic indexing tool for MEDLINE, complementing the traditional
precision and recall method. MATERIALS AND METHODS: The performance
of MTI, the Medical Text Indexer used at NLM to produce MeSH recommendations
for biomedical journal articles is evaluated on a random set of MEDLINE
citations. The evaluation examines semantic similarity at the term
level (indexing terms). In addition, the documents retrieved by queries
resulting from MTI index terms for a given document are compared
to the PubMed related citations for this document. RESULTS: Semantic
similarity scores between sets of index terms are higher than the
corresponding Dice similarity scores. Overall, 75% of the original
documents and 58% of the top ten related citations are retrieved
by queries based on the automatic indexing. CONCLUSIONS: The alternative
measures studied in this paper confirm previous findings and may
be used to select particular documents from the test set for a more
thorough analysis.
BibTeX:
@article{Neveol2006a,
  author = {Neveol, A and Zeng, K and Bodenreider, O},
  title = {Besides precision \& recall: exploring alternative approaches to evaluating an automatic indexing tool for MEDLINE.},
  journal = {AMIA Annu Symp Proc},
  school = {U.S. National Library of Medicine, Bethesda, Maryland, USA. neveola@lhc.nlm.nih.gov},
  year = {2006},
  pages = {589--593},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1839480}
}

Abstract: INTRODUCTION: In order to measure the medical activity in hospitals,
physicians are required to code manually information concerning a
patient's stay using ICD-10. This requires trained staff and a lot
of time. We propose to help speed up and facilitate the tedious task
of coding patient information. METHODS: we show two methods. First,
we propose an automated ICD-10-based coding help system using an
automated MeSH-based indexing system and a mapping between MeSH and
ICD-10 extracted from the UMLS metathesaurus. Secondly, we propose
the use of drug prescriptions to complete the previous coding with
the use of a mapping between a given prescription drug and the relevant
ICD-10 codes (in compliance with the drug approval). RESULTS: the
results of a preliminary experiment indicate that the precision of
the indexing system is 40% and the recall is 30% when we compare
to an economic rules-based coding and to a descriptive coding. Discussion:
moreover, we show that the use of prescription coding is relevant
as the recall reaches 68% when the Vidal tool is used. CONCLUSION:
Then, it is very interesting to complete the coding obtained automatically
by the indexing/mapping system by the coding obtained from the prescriptions.
BibTeX:
@article{Pereira2006,
  author = {Pereira, S and Névéol, A and Massari, P and Joubert, M and Darmoni, SJ},
  title = {Construction of a semi-automated ICD-10 coding help system to optimize medical and economic coding.},
  journal = {Stud Health Technol Inform},
  school = {CISMeF Team., LITIS, Rouen, France.},
  year = {2006},
  volume = {124},
  pages = {845--850}
}

BibTeX:
@inproceedings{Sibert2006b,
  author = {Sibert, L and Darmoni, SJ and Benichou J and Dahamna, B and Weber, J},
  title = {Online clinical reasoning assessment with the Script Concordance test: Results of a French pilot study.},
  booktitle = {12th International Ottawa Conference on Medical Education},
  address = {NY, USA},
  month = {May},
  school = {Department of Urology, Rouen University Hospital, 1, rue de Germont 76031 Rouen Cedex, France. louis.sibert@chu-rouen.fr},
  year = {2006}
}

Abstract: BACKGROUND: The amount of health data accessible on the Web is increasing
and Internet has become a major source of health information. Many
tools and search engines are available but medical information retrieval
remains difficult for both the health professional and the patients.
OBJECTIVE: In this paper we describe heuristics that aim at matching
as much as possible queries with the content of the documents in
the context of the CISMeF catalogue (Catalogue and Index of Health
Resources in French) and its Doc'CISMeF search tool. The queries
are represented by terms and the content of the documents is indexed
by a terminology based on the MeSH thesaurus. RESULTS: Several operations
are performed to match the terms of the terminology: natural language
processing techniques on multi-words queries, phonemisation, spelling
correction, plain text search with adjacency etc.. Each one is tested
to evaluate its contribution in matching the terminology and the
indexed documents. CONCLUSION: The implemented heuristics contribute
significantly with good results in maximising as much as possible
the recall of the Doc'CISMeF search tool.
BibTeX:
@article{Soualmia2006,
  author = {Soualmia, L and Dahamna, B and Thirion, B and Darmoni, SJ},
  title = {Strategies for health information retrieval.},
  journal = {Stud Health Technol Inform},
  school = {CISMeF Team, Rouen University Hospital, Rouen, France.},
  year = {2006},
  volume = {124},
  pages = {595--600}
}

BibTeX:
@inproceedings{Sylvie2006,
  author = {BRUNESSAUX, S and DAHAMNA, B and GALLINARI, P and KASSEL, G and MESNARD, O and PÉCUCHET, JP and SZULMAN, S},
  title = {RNTL Technolangue ATONANT. Aide à l'enrichissement semi-automatique d'ontologies},
  booktitle = {TALN (Traitement automatique des langues naturelles)},
  address = {Leuven, France},
  month = {Avril},
  publisher = {Presses universitaires de Louvain},
  year = {2006},
  edition = {Piet Mertens and Cedrick FAIRON and Anne DISTER et Patrick Watrin (Eds)},
  url = {http://www.technolangue.net/IMG/pdf/Atonant-Taln06.pdf}
}

BibTeX:
@inproceedings{Gehanno2006a,
  author = {Gehanno, JF and Kerdelhué, G and Darmoni, SJ and Fantoni, S and Caillard, J and Frimat, P},
  title = {Veille documentaire en santé au travail.},
  booktitle = {29eme Congrès National de Médecine et Santé au Travail},
  address = {Lyon, France},
  month = {Mai},
  year = {2006}
}

Abstract: PURPOSE: The objective of this work was to assess problem-based learning
(PBL) as a method for teaching information and communication technology
in medical informatics (MI) courses. A study was conducted in the
Schools of Medicine of Rennes and Rouen (France) with third-year
medical students. METHODS: The "PBL-in-MI" sessions included a first
tutorial group meeting, then personal work, followed by a second
tutorial group meeting. A problem that simulated practice and was
focused on information technology was discussed. In Rouen, the students
were familiar with PBL, and they enrolled on a voluntary basis, while
in Rennes, the students were first-ever participants in PBL courses,
and the program was mandatory. One hundred and seventy-seven students
participated in the PBL-in-MI sessions and were given a questionnaire
in order to evaluate qualitatively the sessions. RESULTS AND DISCUSSION:
The response rate was 92.1%. The overall opinion of the students
was good. 69.8% responded positively to the program. In Rouen, where
the students participated in PBL-in-MI sessions on a voluntary basis,
the students were significantly more enthusiastic about PBL-in-MI.
Moreover, attitudes and opinions of students are plausibly related
to differences in previous PBL skills. The fact that the naïve group
had two tutors, one trained and one naïve as the students, has been
investigated. Teacher naivety was an explanatory factor for the differences
between Rennes and Rouen.
BibTeX:
@article{Burgun2006,
  author = {Burgun, A and Darmoni, SJ and Le Duff, F and Wéber, J},
  title = {Problem-based learning in medical informatics for undergraduate medical students: an experiment in two medical schools.},
  month = {May},
  journal = {Int J Med Inform},
  school = {EA 3888, Laboratoire d'Informatique Médicale, Faculté de Médecine, 2 Avenue Pr Léon Bernard, 35043 Rennes, France. Anita.Burgun@univ-rennes1.fr},
  year = {2006},
  volume = {75},
  number = {5},
  pages = {396--402},
  doi = {10.1016/j.ijmedinf.2005.07.014}
}

Abstract: Images play an important role in medical diagnostics and treatment
planning. Whereas medical text retrieval, analysis, and reuse have
been practiced for many years, much less is known on the storage
and reuse of images in a context other than a single patient, although
several medical teaching files with images exist. The aim of automatic
image indexing/retrieval is to provide efficient and fast access
to image collections to reuse stored information. When indexing medical
images, the automatic categorization provides the means of extracting
otherwise unavailable information about the images. Image categorization
is usually applied in a context where a large number of images needs
to be treated automatically and where no or only little text is available.
This study will focus on a database extracted from online resources
of the CISMeF health-catalogue. The aim is to assess the performance
of two medical image categorization architectures in a complex environment
(10322 images, 33 classes, multiple modalities, anatomical regions,
and view-angles). The image database was extracted and annotated
in collaboration with an experienced radiologist. The two compared
systems have very different architectures. MedIC is an architecture
based on machine learning applied to several sets of image texture
and grey-level statistics. It achieves a maximum accuracy of 97.24%
on 32 classes (representing different modalities, anatomical regions
and view angles) and 98.47% on 6 classes (representing only the medical
modality), when using an SVM classifier. MedGIFT on the other hand
is a visual retrieval system where the visually most similar images
are used to classify new images, currently without any learning strategy.
This approach reaches an accuracy of 95.25% for the 32 classes and
97.15% for detecting the modality. By including a proper learning
strategy these results can be expected to increase. The results show
that image categorization has reached an accuracy that can be regarded
as sufficient for many automatic image categorization tasks to get
information on poorly annotated image collections.
BibTeX:
@inproceedings{Florea2006b,
  author = {Florea, F and Müller, H and Rogozan, A and Geissbuhler, A and Darmoni, SJ},
  title = {Medical image categorization with MedIC and MedGIFT},
  booktitle = {Medical Informatics Europe (MIE2006)},
  address = {Maastricht, Netherlands},
  month = {27-30 August},
  year = {2006},
  pages = {3-11}
}

2005


BibTeX:
@article{Gehanno2005,
  author = {Gehanno, JF and Darmoni, SJ and Caillard, JF},
  title = {Major inaccuracies in articles citing occupational or environmental medicine papers and their implications.},
  month = {Jan},
  journal = {J Med Libr Assoc},
  school = {Rouen University Hospital 1 rue de Germont F-76031 Rouen France. Jean-francois.gehanno@chu-rouen.fr},
  year = {2005},
  volume = {93},
  number = {1},
  pages = {118--121},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=545131}
}

Abstract: BACKGROUND: The script concordance (SC) test is an assessment tool
that measures capacity to solve ill-defined problems, that is, reasoning
in context of uncertainty. This tool has been used up to now mainly
in medicine. The purpose of this pilot study is to assess the feasibility
of the test delivered on the Web to French urologists. METHODS: The
principle of SC test construction and the development of the Web
site are described. A secure Web site was created with two sequential
modules: (a) The first one for the reference panel (n = 26) with
two sub-tasks: to validate the content of the test and to elaborate
the scoring system; (b) The second for candidates with different
levels of experience in Urology: Board certified urologists, residents,
medical students (5 or 6th year). Minimum expected number of participants
is 150 for urologists, 100 for residents and 50 for medical students.
Each candidate is provided with an individual access code to this
Web site. He/she may complete the Script Concordance test several
times during his/her curriculum. RESULTS: The Web site has been operational
since April 2004. The reference panel validated the test in June
of the same year during the annual seminar of the French Society
of Urology. The Web site is available for the candidates since September
2004. In six months, 80% of the target figure for the urologists,
68% of the target figure for the residents and 20% of the target
figure for the student passed the test online. During these six months,
no technical problem was encountered. CONCLUSION: The feasibility
of the web-based SC test is successful as two-thirds of the expected
number of participants was included within six months. Psychometric
properties (validity, reliability) of the test will be evaluated
on a large scale (N = 300). If positive, educational impact of this
assessment tool will be useful to help urologists during their curriculum
for the acquisition of clinical reasoning skills, which is crucial
for professional competence.
BibTeX:
@article{Sibert2005,
  author = {Sibert, L and Darmoni, SJ and Dahamna, B and Weber, J and Charlin, B},
  title = {Online clinical reasoning assessment with the Script Concordance test: a feasibility study.},
  journal = {BMC Med Inform Decis Mak},
  school = {Department of Urology, Rouen University Hospital, 1, rue de Germont, 76031 Rouen Cedex, France. louis.sibert@chu-rouen.fr},
  year = {2005},
  volume = {5},
  pages = {18},
  doi = {10.1186/1472-6947-5-18}
}

Abstract: Internet as source of information is increasing in preeminence in
numerous fields, including health. We describe in this paper the
CISMeF project (acronym of Catalogue and Index of French-speaking
Medical Sites) which has been designed to help the health information
consumers and health professionals to find what they are looking
for among the numerous health documents available online. The catalogue
is founded on two standards: a set of metadata and a terminology
based on the MeSH thesaurus which has the same structure and use
as an ontology of the medical domain. The structure of the catalogue
allows us to place the project at an overlap between the present
Web, which is informal, and the forthcoming Semantic Web. Many features
of information retrieval and navigation through the catalogue were
developed. These features take into account the kind of the end-user
(health professional, medical student, patient). The CISMeF-patients
catalogue is a sub-catalogue of CISMeF and is dedicated to the patients
and the general public. It shares the same model as CISMeF whereas
MEDLINE and MedlinePlus do not. We also propose to couple two approaches
(morphological processing and data mining) to help the users by correcting
and refining their queries.
BibTeX:
@article{Soualmia2005,
  author = {Soualmia, L and Darmoni, SJ},
  title = {Combining different standards and different approaches for health information retrieval in a quality-controlled gateway.},
  month = {Mar},
  journal = {Int J Med Inform},
  school = {CISMeF Team, L@STICS, Medical School, Rouen University Hospital, 1, Rue de Germont, 76031 Rouen Cedex, France. lina.soualmia@chu-rouen.fr},
  year = {2005},
  volume = {74},
  number = {2-4},
  pages = {141--150},
  doi = {10.1016/j.ijmedinf.2004.05.012}
}

Abstract: Medical Informatics has a constant need for basic medical language
processing tasks, e.g. for coding into controlled vocabularies, free
text indexing and information retrieval. Most of these tasks involve
term matching and rely on lexical resources: lists of words with
attached information, including inflected forms and derived words,
etc. Such resources are publicly available for the English language
with the UMLS Specialist Lexicon, but not in other languages. For
the French language, several teams have worked on the subject and
built local lexical resources. The goal of the present work is to
pool and unify these resources and to add extensively to them by
exploiting medical terminologies and corpora, resulting in a unified
medical lexicon for French (UMLF). This paper exposes the issues
raised by such an objective, describes the methods on which the project
relies and illustrates them with experimental results.
BibTeX:
@article{Zweigenbaum2005,
  author = {Zweigenbaum, P and Baud, R and Burgun, A and Namer, F and Jarrousse, E and Grabar, N and Ruch, P and Le Duff, F and Forget, JF and Douyère, M and Darmoni, SJ},
  title = {UMLF: a unified medical lexicon for French.},
  month = {Mar},
  journal = {Int J Med Inform},
  school = {STIM/DSI/Assistance Publique-Hôpitaux de Paris, 91, boulevard de l'Hôpital, 75634 Paris Cedex 13, France. pz@biomath.jussieu.fr},
  year = {2005},
  volume = {74},
  number = {2-4},
  pages = {119--124},
  doi = {10.1016/j.ijmedinf.2004.03.010}
}

BibTeX:
@article{Bensefa2005,
  author = {Bensefa, L. and Peyrethon, C. and Gehanno, J.-F.},
  title = {Vaccination contre le virus de l’hépatite {B} et aptitude},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2005},
  volume = {66},
  number = {3},
  pages = {274--275},
  doi = {10.1016/S1775-8785(05)79093-7}
}

Abstract: Objectifs La sous-estimation des maladies d’origine professionnelle
en France est due à de multiples déterminants, notamment à la méconnaissance
par le corps médical de l’origine professionnelle des maladies et
de la réglementation. L’objectif de cette étude est de préciser le
niveau de formation, quantitatif et qualitatif, des étudiants en
médecine en cours dans le cursus de deuxième cycle des études médicales
en France. Matériel et méthodes Cette étude transversale nationale
a été réalisée en 2004 par questionnaire, envoyé à l’ensemble des
facultés métropolitaines (n = 37). Résultats Trente-cinq facultés
(95 ont répondu au questionnaire. La durée moyenne d’enseignement
théorique reçu par un étudiant de deuxième cycle au cours de son
cursus est de 9,1 heures ± 4,4 heures (minimum : 2 h, maximum : 18
h). Bien que la définition des notions d’accident de travail et de
maladies professionnelles soient abordées dans l’ensemble des facultés,
les autres thèmes varient quantitativement et qualitativement d’une
faculté à l’autre. L’assiduité des étudiants est également fluctuante
et environ 30 % des étudiants arrivent en fin de cursus sans avoir
reçu aucun enseignement de médecine du travail. Conclusions L’enseignement
de la médecine du travail lors du deuxième cycle des études médicales
apparaît réduit et inadapté aux enjeux de santé publique posés par
la santé au travail.
BibTeX:
@article{Gehanno2005c,
  author = {Gehanno, J.F. and Choudat, D. and Caillard, J.F.},
  title = {Enseignement de la médecine du travail en deuxième cycle des études médicales en france},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2005},
  volume = {66},
  number = {4},
  pages = {313--317},
  doi = {10.1016/S1775-8785(05)79099-8}
}

BibTeX:
@article{Thirion2005,
  author = {Thirion, B and Bonmarchand, G},
  title = {Comment trouver ou retrouver les recommandations de bonne pratique en langue francaise ou anglaise ?},
  month = {September},
  journal = {Reanimation},
  year = {2005},
  volume = {14},
  pages = {411-415},
  doi = {10.1016/j.reaurg.2005.07.001}
}

BibTeX:
@phdthesis{Neveol2005e,
  author = {Névéol, A},
  title = {Automatisation des tâches documentaires dans un catalogue de santé en ligne},
  school = {INSA de Rouen},
  year = {2005},
  url = {http://aurelie.neveol.free.fr/theseAN.pdf}
}

BibTeX:
@inproceedings{Florea2005,
  author = {Florea, F and Vertan, C and Rogozan, A and Bensrhair, A and Darmoni, SJ},
  title = {Comparison of histogram-based feature sets for medical image modality categorization},
  booktitle = {Proc. International Symposium on Signals, Circuits and Systems ISSCS 2005},
  address = {Iasi, Romania},
  month = {14-15 July},
  year = {2005},
  volume = {1},
  pages = {47--50 Vol. 1},
  doi = {10.1109/ISSCS.2005.1509847}
}

BibTeX:
@inproceedings{Gehanno2005b,
  author = {Gehanno, JF},
  title = {Evidence Based Medicine in occupational health. Why and how to find relevant information on health screening and health surveillance in scientific literature.},
  booktitle = {CME: Health, Work \& Environment},
  address = {Inter-University Centre. Dubrovnik, Croatia},
  month = {September},
  year = {2005}
}

Abstract: Objective :Performing a usability study on two handheld computers
(personal digital assistant and tablet PC), as tools for retrieving
drug information.Materials and methods: A randomised crossover study
was performed: 34 students in pharmacy and medicine used the two
handheld tools in a randomised order, to answer a questionnaire containing
12 questions covering all the aspects of a drug database and a qualitative
analysis on six different items to measure access to drug information.
The availability of the drug information database Vidal on PDA and
on tablet PC implied our choice of the database. Three main criteria
for evaluation were chosen: success rates, time-on-task, and number
of clicks.Results: There were no significant differences between
the two groups neither on age, sex, medical discipline, study years
nor previous computer practice. The success rate is significantly
higher with the PDA for only one question. The PDA is significantly
faster than the tablet PC on 7 of the 12 questions and generates
fewer clicks for 3 questions. Compared to the tablet PC, it appears
that the PDA is better in terms of clearness, navigability and usefulness
for professional practice and it is the only tool which is significantly
preferred to all other supports.Conclusion: In this study with students,
the PDA is significantly more effective quantitatively and qualitatively
than the tablet PC to retrieve drug information.
BibTeX:
@article{Letellier2005,
  author = {Letellier, S and Leuraud, K and Arnaud, P and Darmoni, SJ},
  title = {Usability study on two handheld computers to retrieve drug information.},
  journal = {Stud Health Technol Inform},
  school = {L@STICS, PSI laboratory, FRE CNRS 2645, Rouen University, France.},
  year = {2005},
  volume = {116},
  pages = {322--327},
  url = {http://www.magic5.unile.it/PapDoc/Article/MIE2005/TOC%20Scientific%20Contributions/Handheld%20and%20Wireless%20Computing/290.pdf}
}

BibTeX:
@inproceedings{Neveol2005d,
  author = {Névéol, A and Mary, V and Gaudinat, A and Rogozan, A and Darmoni, SJ},
  title = {A Benchmark Evaluation of the French MeSH Indexing Systems},
  booktitle = {10th Conference on Artificial Intelligence in Medicine},
  year = {2005},
  url = {http://www.chu-rouen.fr/l@stics/NeveolAIME05long.pdf}
}

Abstract: OBJECTIVE: This paper presents the evaluation of two MeSH indexing
systems for French and English on a parallel corpus. MATERIAL AND
METHODS: We describe two automatic MeSH in-dexing systems - MTI for
English, and MAIF for French. The French version of the evaluation
resources has been manually indexed with MeSH keyword/qualifier pairs.
This professional indexing is used as our gold standard in the evaluation
of both systems on keyword retrieval. RESULTS: The English system
(MTI) obtains significantly better precision and recall (78% precision
and 21% recall at rank 1, vs. 37%. precision and 6% recall for
MAIF ). Moreover, the performance of both systems can be optimised
by the break-age function used by the French system (MAIF), which
selects an adaptive number of descriptors for each resource indexed.
CONCLUSION: MTI achieves better performance. However, both systems
have features that can benefit each other.
BibTeX:
@article{Neveol2005,
  author = {Névéol, A and Mork, J and Aronson, AR and Darmoni, SJ},
  title = {Evaluation of French and English MeSH indexing systems with a parallel corpus.},
  journal = {AMIA Annu Symp Proc},
  school = {Laboratoire PSI-FRE 2645 CNRS -INSA de Rouen, France. aneveol@insa-rouen.fr},
  year = {2005},
  pages = {565--569},
  url = {http://www.chu-rouen.fr/l@stics/NeveolAMIA2005.pdf}
}

Abstract: The "Université Médicale Virtuelle Francophone" (UMVF) is a federation
of French medical schools. Its main goal is to share the production
and use of pedagogic medical resources generated by academic medical
teachers. We developed an Open-Source application based upon a workflow
system which provides an improved publication process for the UMVF.
For teachers, the tool permits easy and efficient upload of new educational
resources. For web masters it provides a mechanism to easily locate
and validate the resources. For both the teachers and the web masters,
the utility provides the control and communication functions that
define a workflow system.For all users, students in particular, the
application improves the value of the UMVF repository by providing
an easy way to find a detailed description of a resource and to check
any resource from the UMVF to ascertain its quality and integrity,
even if the resource is an old deprecated version. The server tier
of the application is used to implement the main workflow functionalities
and is deployed on certified UMVF servers using the PHP language,
an LDAP directory and an SQL database. The client tier of the application
provides both the workflow and the search and check functionalities
and is implemented using a Java applet through a W3C compliant web
browser. A unique signature for each resource, was needed to provide
security functionality and is implemented using the MD5 Digest algorithm.
The testing performed by Rennes and Lille verified the functionality
and conformity with our specifications.
BibTeX:
@article{Renard2005,
  author = {Renard, JM and Brunetaud, JM and Cuggia, M and Darmoni, SJ and Lebeux, P and Beuscart, R},
  title = {An Improved Publication Process for the UMVF.},
  journal = {Stud Health Technol Inform},
  school = {CERIM, faculté de médecine, Université Lille2.},
  year = {2005},
  volume = {116},
  pages = {279--283}
}

BibTeX:
@inproceedings{Darmoni2005,
  author = {Darmoni, SJ},
  title = {Les sites Internet éducatifs et de prévention},
  booktitle = {Le patient au c?ur du système d?information de santé. Congrès du Graph},
  address = {Marseille, France},
  month = {Janvier},
  year = {2005},
  url = {http://gestions-hospitalieres.fr/article.php?ref_article=2386}
}

BibTeX:
@inproceedings{Florea2005b,
  author = {Florea, F and Rogozan, A and Bensrhair, A and Dacher J-N and Darmoni, SJ},
  title = {Recherche des images médicales par contenu et type de ressource dans un catalogue de santé en ligne},
  booktitle = {JFIM Journées Francophones d'Informatique Médicale},
  address = {Lille, France},
  month = {12-13 mai},
  year = {2005},
  series = {1-7},
  url = {http://litismail.insa-rouen.fr/MnemosNet/psipubli.nsf/ce6c2c540f564a2dc125680200361b7c/96a6886bc83ef1fbc1256fd30030933d/$FILE/11-Florea-Jfim05.pdf}
}

BibTeX:
@inproceedings{Florea2005c,
  author = {Florea, F and Rogozan, A and Bensrhair, A and Darmoni, SJ},
  title = {Medical image retrieval by content and keyword in an on-line health-catalogue context},
  booktitle = {Computer Vision/Computer Graphics Collaboration Techniques and Applications (Mirage2005)},
  address = {INRIA Rocquencourt, France},
  year = {2005},
  pages = {229-236}
}

BibTeX:
@inproceedings{Gehanno2005a,
  author = {Gehanno, JF and Thirion, B and Darmoni, SJ and Caillard JF},
  title = {La recherche documentaire sur le risque cancérogène par le médecin du travail.},
  booktitle = {Journées Nationales de Santé au Travail dans le BTP},
  year = {2005},
  volume = {28},
  pages = {51-53},
  url = {http://www.gnmbtp.org/references_documentaires/congres_2005/9.rechdocu-gehanno.pdf}
}

BibTeX:
@inproceedings{Ladner2005,
  author = {Ladner, J and Roussel, F and Audureau, E and Girault, C and Menard, JF and Sibert, L and Darmoni, SJ},
  title = {Evolution de l'utilisation d'Internet par les étudiants en médecine lors des enseignements par APP.},
  booktitle = {JFIM},
  year = {2005},
  url = {http://www.univ-lille2.fr/jfim2005/papiers/48-ladner-jfim2005.pdf}
}

BibTeX:
@inproceedings{Letellier2005a,
  author = {Letellier, S and Leuraud, K and Darmoni, SJ},
  title = {Etude d'utilisabilité de deux outils nomades pour accéder à une base de connaissances sur le médicament.},
  booktitle = {JFIM},
  year = {2005},
  url = {http://www.univ-lille2.fr/jfim2005/papiers/04-Letellier-JFIM2005.pdf}
}

Abstract: Le projet Cogni-CISMeF vise à construire un système de dialogue Homme-Machine
(DHM) en langue naturelle afin d?améliorer l?interface qui permet
d?accéder à un annuaire de recherche de ressources médicales sur
le Web (CISMeF). L?amorce de ce système peut s?envisager selon deux
approches :

? l?analyse de dialogues recueillis entre un expert hu-main de la
technologie CISMeF et des utilisateurs ;

? l?analyse de dialogues entre des utilisateurs et un système minimal
de dialogue homme-machine, im-plémenté directement sur l?internet
et qui évoluera progressivement.

Nous réfléchissons à une modélisation informatique de la théorie de
la pertinence issue des recherches en pragma-tique cognitive.
BibTeX:
@inproceedings{LOISEL2005,
  author = {LOISEL, A and KOTOWICZ, JP and CHAIGNAUD, N and DARMONI, SJ},
  title = {Un système de dialogue homme-machine pour un moteur de recherche de documents médicaux (Poster)},
  booktitle = {7ème Conférence Francophone sur l'interaction Homme-Machine, IHM'05,},
  address = {Toulouse, France},
  month = {septembre},
  year = {2005},
  pages = {31-34}
}

Abstract: Le projet Cogni-CISMeF vise à construire un système de dialogue Homme-Machine
(DHM) en langue naturelle afin d?améliorer l?interface qui permet
d?accéder à un annuaire de recherche de ressources médicales sur
le Web (CISMeF). L?amorce de ce système peut s?envisager selon deux
approches :

? l?analyse de dialogues recueillis entre un expert hu-main de la
technologie CISMeF et des utilisateurs ;

? l?analyse de dialogues entre des utilisateurs et un système minimal
de dialogue homme-machine, im-plémenté directement sur l?internet
et qui évoluera progressivement.

Nous réfléchissons à une modélisation informatique de la théorie de
la pertinence issue des recherches en pragma-tique cognitive.
BibTeX:
@inproceedings{LOISEL2005a,
  author = {LOISEL, A and KOTOWICZ, JP and CHAIGNAUD, N and DARMONI, SJ},
  title = {Un système de dialogue homme-machine pour un moteur de recherche de documents médicaux (Poster)},
  booktitle = {2èmes rencontres des Sciences et Technologies de l'Information},
  address = {Clermont Ferrand, France},
  month = {octobre},
  year = {2005},
  pages = {31-34}
}

BibTeX:
@inproceedings{Neveol2005a,
  author = {Neveol, A and Florea, F and Thirion, B and Darmoni, SJ},
  title = {Formalisation de règles d'indexation MeSH pour un usage automatique},
  booktitle = {Journées INTEX/NOOJ},
  address = {Besançon, France},
  month = {30 May - 1 June},
  year = {2005},
  url = {http://laseldi.univ-fcomte.fr/document/colloque/nooj_2005/022NEVEOL.htm}
}

BibTeX:
@inproceedings{Neveol2005c,
  author = {Névéol, A and Ozdowska, S},
  title = {Extraction de termes médicaux à partir d'un corpus parallèle anglais/français},
  booktitle = {Extraction et Gestion des Connaissances},
  address = {Paris, France},
  month = {Janvier},
  year = {2005},
  pages = {655-664},
  url = {http://w3.univ-tlse2.fr/erss/textes/pagespersos/ozdowska/publis/neveol-ozdowska-egc05.pdf}
}

BibTeX:
@inproceedings{Neveol2005b,
  author = {Névéol, A and Rogozan, A and Darmoni, SJ},
  title = {Indexation automatique de ressources de santé à l'aide de paires de descripteurs MeSH.},
  booktitle = {TALN},
  address = {Dourdan, France},
  month = {Juin},
  year = {2005},
  volume = {1},
  pages = {475-480},
  url = {http://taln.limsi.fr/site/talnRecital05/tome1/P54.pdf}
}

BibTeX:
@inproceedings{Ozdowska2005,
  author = {Ozdowska, S and Névéol A and Thirion, B},
  title = {Traduction compositionnelle automatique de bitermes dans des corpus anglais/français alignés.},
  booktitle = {6èmes rencontres Terminologie et Intelligence Artificielle},
  year = {2005},
  pages = {83-94},
  url = {http://www.loria.fr/%7Eyannick/TIA2005/doc/ozdowska.pdf}
}

BibTeX:
@inproceedings{Pereira2005,
  author = {Pereira, S and Névéol, A and Massari, P and Darmoni, SJ},
  title = {Evaluation de plusieurs terminologies médicales pour optimiser l'aide au codage médico-économique par analyse automatique de dossiers électroniques de patient},
  booktitle = {Congrès ASTI},
  address = {Clermont Ferrand, France},
  month = {Octobre},
  year = {2005}
}

Abstract: Our work is concerned with the automatic indexing of medical images
for image retrieval purposes inside a large on-line health-catalogue.
We present, in this paper, a rule-based medical-image modality categorization
approach. The modality information is important for the indexing
of medical images present in on-line health documents (thus, mainly
in JPEG format). In fact, contrary to the case of the DICOM images,
extensively used in PACS systems, JPEG images have any attached metadata
(like those present in DICOM headers). Our system is based on the
automatic interpretation of textual annotations, once they are extracted
from the medical image by image processing and optical character
recognition techniques. The system performances were tested on a
medical image database, containing six medical modalities: angiography,
ultrasonography, magnetic resonance imaging, standard radiography,
computer tomography, and scintigraphy. The extraction of this database
from a live health environment ensures the diversity of content from
the modality, anatomical region and pathological point of view. In
order to determinate the medical image modality, the textual annotations
have been interpreted using a set of 96 production rules defined
by our expert radiologist. The high precision rate of our categorization
system ( 90%), proves that textual annotations present in medical
images are very reliable indicators of the medical modality. Further
work will concern the fusion of our rule-based system with an already
implemented visual-content based system, for a robust image modality
categorization.
BibTeX:
@inproceedings{Florea2005d,
  author = {Florea, F and Rogozan, A and Bensrhair, A and Dacher, J-N and Darmoni, S},
  title = {Modality categorisation by textual annotations interpretation in medical imaging},
  booktitle = {Connecting Medical Informatics and Bio-Informatics, Medical Informatics Europe (MIE2005)},
  month = {October},
  year = {2005},
  pages = {1270-1275}
}

2004


Abstract: BACKGROUND: It is an absolute necessity to continually assess the
quality of health information on the Internet. Quality-controlled
subject gateways are Internet services which apply a selected set
of targeted measures to support systematic resource discovery. METHODS:
The CISMeF health gateway became a contributor to the MedCIRCLE project
to evaluate 270 health information providers. The transparency heritage
consists of using the evaluation performed on providers that are
referenced in the CISMeF catalogue for evaluating the documents they
publish, thus passing on the transparency label from the publishers
to their documents. RESULTS: Each site rated in CISMeF has a record
in the CISMeF database that generates an RDF into HTML file. The
search tool Doc'CISMeF displays information originating from every
publisher evaluated with a specific MedCIRCLE button, which is linked
to the MedCIRCLE central repository. Starting with 270 websites,
this trust heritage has led to 6,480 evaluated resources in CISMeF
(49.8% of the 13,012 resources included in CISMeF). CONCLUSION:
With the MedCIRCLE project and transparency heritage, CISMeF became
an explicit third party.
BibTeX:
@article{Darmoni2004,
  author = {Darmoni, SJ and Dahamna, B and Roth-Berghofer, T},
  title = {Seal of transparency heritage in the CISMeF quality-controlled health gateway.},
  month = {Sep},
  journal = {BMC Med Inform Decis Mak},
  school = {CISMeF, Rouen University Hospital, France. Stefan.Darmoni@chu-rouen.fr.},
  year = {2004},
  volume = {4},
  pages = {15},
  doi = {10.1186/1472-6947-4-15}
}

Abstract: The amount of health information available on the Internet is considerable.
In this context, several health gateways have been developed. Among
them, CISMeF (Catalogue and Index of Health Resources in French)
was designed to catalogue and index health resources in French. The
goal of this article is to describe the various enhancements to the
MeSH thesaurus developed by the CISMeF team to adapt this terminology
to the broader field of health Internet resources instead of scientific
articles for the medline bibliographic database. CISMeF uses two
standard tools for organizing information: the MeSH thesaurus and
several metadata element sets, in particular the Dublin Core metadata
format. The heterogeneity of Internet health resources led the CISMeF
team to enhance the MeSH thesaurus with the introduction of two new
concepts, respectively, resource types and metaterms. CISMeF resource
types are a generalization of the publication types of medline. A
resource type describes the nature of the resource and MeSH keyword/qualifier
pairs describe the subject of the resource. A metaterm is generally
a medical specialty or a biological science, which has semantic links
with one or more MeSH keywords, qualifiers and resource types. The
CISMeF terminology is exploited for several tasks: resource indexing
performed manually, resource categorization performed automatically,
visualization and navigation through the concept hierarchies and
information retrieval using the Doc'CISMeF search engine. The CISMeF
health gateway uses several MeSH thesaurus enhancements to optimize
information retrieval, hierarchy navigation and automatic indexing.
BibTeX:
@article{Douyere2004,
  author = {Douyère, M and Soualmia, L and Névéol, A and Rogozan, A and Dahamna, B and Leroy, JP and Thirion, B and Darmoni, SJ},
  title = {Enhancing the MeSH thesaurus to retrieve French online health resources in a quality-controlled gateway.},
  month = {Dec},
  journal = {Health Info Libr J},
  school = {CISMeF, Rouen University Hospital, Medical School, University of Rouen, Rouen, France.},
  year = {2004},
  volume = {21},
  number = {4},
  pages = {253--261},
  doi = {10.1111/j.1471-1842.2004.00526.x}
}

Abstract: INTRODUCTION: CISMeF is a Quality Controlled Health Gateway using
a terminology based on the Medical Subject Headings (MeSH) thesaurus
that displays medical specialties (metaterms) and the relationships
existing between them and MeSH terms. Objective: The need to classify
the resources within the catalogue has led us to combine this type
of semantic information with domain expert knowledge for health resources
categorization purposes. Material and METHODS: A two-step categorization
process consisting of mapping resource keywords to CISMeF metaterms
and ranking metaterms by decreasing coverage in the resource has
been developed. We evaluate this algorithm on a random set of 123
resources extracted from the CISMeF catalogue. Our gold standard
for this evaluation is the manual classification provided by a domain
expert, viz. a librarian of the team. RESULTS: The CISMeF algorithm
shows 81% precision and 93% recall, and 62% of the resources were
assigned a "fully relevant" or "fairly relevant" categorization according
to strict standards. DISCUSSION: A thorough analysis of the results
has enabled us to find gaps in the knowledge modeling of the CISMeF
terminology. The necessary adjustments having been made, the algorithm
is currently used in CISMeF for resource categorization.
BibTeX:
@article{Neveol2004,
  author = {Névéol, A and Soualmia, L and Douyère, M and Rogozan, A and Thirion, B and Darmoni, SJ},
  title = {Using CISMeF MeSH "Encapsulated" terminology and a categorization algorithm for health resources.},
  month = {Feb},
  journal = {Int J Med Inform},
  school = {CISMeF, Rouen University Hospital, Rouen Cedex, France.},
  year = {2004},
  volume = {73},
  number = {1},
  pages = {57--64},
  doi = {10.1016/j.ijmedinf.2003.09.004}
}

BibTeX:
@article{Czernichow2004,
  author = {Czernichow, P. and Gehanno, J.F. and Carli, M.P. and Henry-Amar, M. and Van Elslande, J. and Bohu, M. and Peau, M. and Chastan, S.},
  title = {P3-3 {Investigation} d’une suspicion d’agrégat de leucémie dans la zone de gaillon ({Eure})},
  journal = {Revue d'épidémiologie et de santé publique},
  year = {2004},
  volume = {52},
  pages = {77--77},
  doi = {10.1016/S0398-7620(04)99241-3}
}

BibTeX:
@article{Gehanno2004,
  author = {Gehanno, JF and Darmoni, SJ and Caillard, JF},
  title = {Erreurs dans les bibliographies des articles citant des publications de sante au travail. Une menace pour l'Evidence Based Medicine},
  month = {May},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2004},
  volume = {65},
  pages = {195},
  url = {http://www.sciencedirect.com/science/article/B8JFG-4RBV0BK-7S/2/2ec8d80eb1cc603d3d3530822330d83e},
  doi = {10.1016/S1775-8785(04)93253-5}
}

BibTeX:
@article{Rouget-Mejjad2004,
  author = {Rouget-Mejjad, I. and Gehanno, J.F. and Caillard, J.F.},
  title = {Multidisciplinarité et automutilation à l’hôpital : place du médecin du travail dans la prise en charge réussie d’une infirmière souffrant d’un syndrome de {Lasthénie} de {Ferjol}},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2004},
  volume = {65},
  number = {2},
  pages = {231--231},
  doi = {10.1016/S1775-8785(04)93318-8}
}

BibTeX:
@article{Rouget-Mejjad2004a,
  author = {Rouget-Mejjad, I. and Gouiffes, A. and Garand, A. and Turquier, I. and Ducerf, B. and Fouache, M. and Frelet, B. and Gehanno, J.F. and Caillard, J.F.},
  title = {Réseau d’{Analyse} et d’{Intervention} face à la {Violence} et au {Harcèlement} au {Travail} : {RAIVHAT}. {Approche} multidisciplinaire du harcèlement : l’expérience du {CHU} de {Rouen}},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2004},
  volume = {65},
  number = {2},
  pages = {150--150},
  doi = {10.1016/S1775-8785(04)93172-4}
}

BibTeX:
@phdthesis{Soualmia2004e,
  author = {Soualmia, L},
  title = {Etude et Evaluation d'Approches Multiples de Projection de Requêtes pour une Recherche d'Information Intelligente. Application au domaine de la Santé sur l'Internet. Thèse d'informatique},
  school = {INSA de Rouen},
  year = {2004},
  url = {http://www.chu-rouen.fr/l@stics/Lina_Soualmia_These_Version_PDF.pdf}
}

BibTeX:
@inproceedings{Gehanno2004a,
  author = {Gehanno, JF},
  title = {The Usefulness of Available Databases on Self Training.},
  booktitle = {EASOM Summer School},
  address = {Belgrade, Serbia},
  month = {August},
  year = {2004}
}

BibTeX:
@inproceedings{Soualmia2004,
  author = {Soualmia, L and Darmoni, SJ},
  title = {Correcting and Refining Users QUeries: the Contribution of Morphological Knowledge and Association rules.},
  booktitle = {IPMU, Information Processing and Management of Uncertainty in Knowledge-Based Systems},
  address = {Perugia, Italy},
  month = {July},
  year = {2004},
  pages = {2059?2066}
}

Abstract: Information retrieval remains problematic in spite of the numerous
existing search engines. It is the same problem for health information
retrieval. We propose in this paper to combine three knowledge-based
methods to enhance information retrieval using query expansion in
the context of the CISMeF project (Catalogue and Index of French-speaking
Medical Sites) in which the resources are indexed according to a
structured terminology of the medical domain and a set of metadata.
The first method consists of building and using morphological knowledge
of the terms. The second method consists of extracting association
rules between terms by applying a data mining technique over the
indexed resources. The last method consists of formalizing the terminology
using the OWL-DL language to benefit from its powerful reasoning
mechanisms. We describe how these methods could be used conjointly
in the KnowQuE prototype (Knowledge-based Query Expansion) and we
give some preliminary results.
BibTeX:
@inproceedings{Soualmia2004a,
  author = {Soualmia, L and Darmoni, SJ},
  title = {Combining Knowledge-based Methods to Refine and Expand Queries in Medicine.},
  booktitle = {Flexible Query Answering Systems},
  year = {2004},
  pages = {243-255},
  doi = {10.1007/b98090}
}

BibTeX:
@inproceedings{Soualmia2004b,
  author = {Soualmia, L and Golbreich, C and Darmoni, SJ},
  title = {Representing the MeSH in OWL: Towards a semi-automatic migration.},
  booktitle = {KR-MED 2004, Workshop on Knowledge Representation in Biomedicine},
  address = {Whistler, BC, Canada},
  month = {July},
  year = {2004},
  url = {http://sunsite.informatik.rwth-aachen.de/Publications/CEUR-WS/Vol-102/soualmia.pdf}
}

BibTeX:
@inproceedings{Thirion2004,
  author = {Thirion, B and Douyère, M and Soualmia, L and Dahamna, B and Leroy, JP and Darmoni, SJ},
  title = {Metadata element sets in the CISMeF Quality-Controlled Health Gateway.},
  booktitle = {International Conference on Dublin Core and Metadata Applications},
  address = {Shanghai, China},
  month = {October},
  year = {2004},
  url = {http://journals.sfu.ca/dcpapers/2004/Paper_13.pdf}
}

BibTeX:
@inproceedings{Gehanno2004b,
  author = {Gehanno, JF and Darmoni, SJ and Caillard, JF},
  title = {Erreurs dans les bibliographies des articles citant des publications de santé au travail. Une menace pour l'Evidence Based Medicine.},
  booktitle = {28eme Congrès National de Médecine et Santé au Travail},
  address = {Bordeaux, France},
  month = {Juin},
  year = {2004}
}

BibTeX:
@inproceedings{A.2004,
  author = {Névéol, A},
  title = {Indexation automatique de ressources de santé à l?aide d?un vocabulaire contrôlé},
  booktitle = {Rencontre des Etudiants Chercheurs en Informatique pour le Traitement Automatique des Langues (RECITAL)},
  address = {Fès, Maroc},
  month = {Avril},
  year = {2004},
  url = {http://aune.lpl.univ-aix.fr/jep-taln04/proceed/actes/recital2004/Neveol.rec04.pdf}
}

BibTeX:
@inproceedings{Neveol2004c,
  author = {Névéol, A and Douyère, M and Rogozan, A and Darmoni, SJ},
  title = {Construction de ressources terminologiques en santé pour un système d?indexation automatique.},
  booktitle = {Journées INTEX/NOOJ},
  address = {Tours, France},
  year = {2004}
}

BibTeX:
@inproceedings{Neveol2004b,
  author = {Névéol, A and Soualmia, L and Rogozan, A and Douyère, M and Thirion, B and Darmoni, SJ},
  title = {Caractérisation des contenus de l?Internet en santé : l'exemple CISMeF.},
  booktitle = {Journée ATALA},
  address = {Paris, France},
  month = {Janvier},
  year = {2004},
  url = {http://aurelie.neveol.free.fr/NeveolATALA04.pdf}
}

BibTeX:
@inproceedings{Louis2004,
  author = {Sibert, L and Dahamna, B and Darmoni, SJ and Weber, J and Lechevallier, J and Lanson, Y},
  title = {Evaluation du raisonnement clinique en urologie},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Grenoble, France},
  month = {Octobre},
  year = {2004},
  url = {http://www.canal-u.fr/index.php/canalu/producteurs/canal_u_medecine/dossier_programmes/urologie/colloque_et_evenement__1/ipm_2004_evaluation_du_raisonnement_clinique_en_urologie}
}

BibTeX:
@inproceedings{Soualmia2004d,
  author = {Soualmia, LF and Dahamna, B and Darmoni, SJ.},
  title = {Représentation du thésaurus MeSH et de la terminologie CISMeF en OWL.},
  booktitle = {Second Séminaire Web Seménantique Médical},
  address = {Rouen, France},
  month = {Mars},
  year = {2004}
}

BibTeX:
@inproceedings{Soualmia2004c,
  author = {Soualmia, L and Névéol, A and Rogozan, A and Douyère, M and Thirion, B and Darmoni, SJ},
  title = {Une Terminologie du Domaine Médical : Structure et Exploitation.},
  booktitle = {Atelier ATALA},
  address = {Lyon, France},
  month = {Janvier},
  year = {2004}
}

BibTeX:
@inproceedings{Burgun2004,
  author = {Burgun, A and Darmoni, SJ and Le Duff, F and Weber, J},
  title = {Combining problem-based learning and information technology: an experiment with third-year medical students.},
  booktitle = {11th International Ottawa Conference on Medical Education},
  address = {Barcelona, Spain},
  month = {July},
  year = {2004}
}

BibTeX:
@inproceedings{Dahamna2004,
  author = {Dahamna, B and Darmoni, SJ and Roth-Berghofer, TR and Köhler, C and Mayer, MA and Noelle, G and Eysenbach G},
  title = {Trust heritage in a Quality-Controlled Health Gateway.},
  booktitle = {Medinfo 2004, Eleventh World Congress on Health and Medical Informatics},
  address = {San Francisco, USA},
  month = {September},
  year = {2004},
  pages = {1564}
}

Abstract: Summary: Objective: Measuring the impact of training on student-users
of CISMeF (Catalog and Index of Health Resources on the Internet)
quality-controlled health gateway.

Design: Prospective group-randomised technological trial Participants:
Fifty-six third-year medical students of the Rouen Medical School,
France on a voluntary basis. One group with training (28); one group
untrained (28). Participants were directed to use the CISMeF health
information portal (URL: www.chu-rouen.fr or www.cismef.org) to find
one teaching document dealing with each of the following objectives:
semiology of asthma, main germs of infectious endocarditis, risk
factors of colon cancer, and aetiology of hematuria Main outcome
measures: Success or failure to find a teaching document in a maximum
of 10 minutes, time spent and number of clicks to find it.

Results: One-hour training session significantly improved the students?
ability to search and access teaching resources: 64% of the students
(18 out of 28) found a valid teaching resource for each teaching
objective in the untrained group vs. 96% (27 out of 28) in the trained
group (p=0.005, Fisher?s exact test).

Conclusion: Health information portals may increase access to quality-controlled
teaching documents.
BibTeX:
@inproceedings{Darmoni2004b,
  author = {Darmoni, SJ and Douyère, M and Sibert, L and Hamon, A and Leuraud, K and Benichou, J and Weber, J},
  title = {Assessment of a quality-controlled health gateway to facilitate access to teaching resources on the Internet: a technological trial.},
  booktitle = {Ottawa Conference on Medical Education},
  address = {Barcelona, Spain},
  month = {July},
  year = {2004}
}

BibTeX:
@inproceedings{Darmoni2004a,
  author = {Darmoni, SJ and Thirion, B and Douyère, M and Dahamna, B and Weber, J},
  title = {A Quality-Controlled Health Gateway to disseminate French pre-Residency Examination Program teaching resources on the Internet.},
  booktitle = {Medinfo 2004, Eleventh World Congress on Health and Medical Informatics},
  address = {San Francisco, USA},
  month = {September},
  year = {2004}
}

BibTeX:
@inproceedings{Neveol2004a,
  author = {Névéol, A and Rogozan, A and Darmoni, SJ},
  title = {Automatic indexing of health resources in French with a controlled vocabulary for the CISMeF catalogue: a preliminary study.},
  booktitle = {Medinfo 2004, Eleventh World Congress on Health and Medical Informatics},
  address = {San Francisco, USA},
  month = {September},
  year = {2004},
  url = {http://aurelie.neveol.free.fr/NeveolMedinfo04.pdf}
}

BibTeX:
@inproceedings{Sibert2004,
  author = {Sibert, L and Dahamna, B and Darmoni, SJ and Weber, J and Lechevallier, J},
  title = {A Website to validate the Script Concordance test on a large scale: A pilot study in Urology.},
  booktitle = {11th International Ottawa Conference on Medical Education},
  address = {Barcelona, Spain},
  month = {July},
  year = {2004}
}

BibTeX:
@inproceedings{Wascat2004,
  author = {Wascat, C and Beuscart-Zéphir, MC and Anceaux, F and Alao, O and Darmoni, SJ},
  title = {Evaluation of the difficulties faced by users of a search engine of a medical web site : the example of Doc?CISMeF},
  booktitle = {Medinfo 2004, Eleventh World Congress on Health and Medical Informatics},
  address = {San Francisco, USA},
  month = {September},
  year = {2004},
  url = {http://www.univ-lille2.fr/evalab/publisPDF/68%20wascat%20medinfo%202004.pdf}
}

2003


Abstract: OBJECTIVE: An assessment of the quality of health information on the
Internet is an absolute necessity. In this study 'sensitive' information
was defined as information found in documents published on the Internet,
which could be used in a medical decision. For sensitive information,
the main criterion chosen for the quality of the information was
an indication of the level of evidence. A survey was conducted using
the CISMeF health catalogue to assess how often a score of the level
of evidence is mentioned in the information accessible on the Internet
in French-language health resources. METHODS: Since 1999, members
of the CISMeF team have systematically been searching for all documents
containing 'sensitive' information and verifying whether the level
of evidence was explicitly indicated as a score at least once in
the document. RESULTS: As of June 2001, 10,190 resources were included
in CISMeF; including 2964 textual 'sensitive' resources (29.1.
Out of all these resources, only 4.7% (95% confidence interval:
4.0 - 5.5 indicated the level of evidence. A statistically significant
difference in the prevalence of indicating the level of evidence
according to resource types (e.g., 18.1% for guidelines compared
to 0.0% for teaching material), year of publication (almost three
times greater in 1997-2001 compared with 1990-1996) and publishers
was observed. CONCLUSION: As the number of people accessing the growing
amount of information on the Internet is increasing daily, publishers
have an ethical obligation to inform their readers about the validity
of 'sensitive' information their sites contain. However, the vast
majority of the French language Internet resources that were surveyed
do not mention a score of the level of evidence for their sensitive
information.
BibTeX:
@article{Darmoni2003a,
  author = {Darmoni, SJ and Amsallem, E and Haugh, M and Lukacs, B and Leroux, V and Thirion, B and Weber, J and Boissel, JP},
  title = {Level of evidence as a future gold standard for the content quality of health resources on the internet.},
  journal = {Methods Inf Med},
  school = {Rouen University Hospital, Rouen University Hospital, France. Stefan.Darmoni@chu-rouen.fr},
  year = {2003},
  volume = {42},
  number = {3},
  pages = {220--225},
  doi = {10.1267/METH03030220}
}

Abstract: There is a lack of data on environmental benzene exposure in children.
In this study, we compared personal benzene exposure and inhalation
uptake in a group of children to those of their parents. We also
compared levels of urinary benzene metabolites, trans,trans-muconic
acid (MA) and hydroquinone (HQ), for those two groups, and assessed
the correlation between personal benzene exposure and urinary MA
and HQ concentrations. The study was performed on 21, 2-3-year-old
children and their parents recruited on a voluntary basis among non-smokers
from the three largest day-care centers of the town of Rouen in France.
Average benzene concentrations were measured over 5 consecutive days
with diffusive samplers. The following simultaneous measurements
were carried out: personal exposure of the parents, concentrations
inside and outside the day care centers, and inside the volunteer's
bedrooms. Morning and evening urine samples were collected during
the same period. Benzene personal exposure levels were 14.4+/-7.7
microg/m(3) and 11.09+/-6.15 microg/m(3) in parents and children,
respectively. Benzene inhalation uptake estimates were 2.51+/-1.23
microg/kg/day in the group of parents and 5.68+/-3.17 microg/kg/day
in the group of children. Detectable levels of MA and HQ were found
in 85% and 100% of the samples, respectively. Intra-individual
variation of urinary MA and HQ concentrations expressed as a coefficient
of variation (CV) ranged from 63 to 232% and from 13 to 144 respectively.
Mean values of MA and HQ (in mg/g creatinine) were 1.6- and 1.8-fold
higher in the group of children than in the group of parents (P=0.008
and Ptextless0.0001, respectively). Significant correlations between
metabolites levels and benzene were not found.
BibTeX:
@article{Kouniali2003,
  author = {Kouniali, Amin and Cicolella, Andre and Gonzalez-Flesca, Norbert and Dujardin, Roland and Gehanno, Jean Francois and Bois, Frederic Y.},
  title = {Environmental benzene exposure assessment for parent-child pairs in {Rouen}, {France}.},
  month = {June},
  journal = {The Science of the total environment},
  year = {2003},
  volume = {308},
  number = {1-3},
  pages = {73--82},
  doi = {10.1016/S0048-9697(02)00631-9}
}

Abstract: Les technologies de l'information et de la communication prennent
une place de plus en plus importante dans les Facultés de médecine.
Il peut s'agir de l'utilisation de polycopiés sur le WEB au lieu
des polycopiésclassiques, de l'offre de ressources utilisant le multimédia
et l'interactivité, ou encore de l'apprentissage de la pratique médicale
à l'aide de patients virtuels. Le projet d'Université médicale virtuelle
francophone mis en place en 1999 sera développé dans l'article. Parmi
les avantages attendus de ces techniques on peut évoquer l'autonomie
d'apprentissage des étudiants, et leur envie de continuer à se former.
BibTeX:
@article{DARMONI2003,
  author = {DARMONI, SJ and THIBAUT, F and WEBER, J},
  title = {L'universite medicale virtuelle},
  journal = {Confrontations psychiatriques.},
  year = {2003},
  number = {44},
  pages = {147-154},
  url = {http://cat.inist.fr/?aModele=afficheN&cpsidt=17304044}
}

Abstract: Le nombre de ressources disponibles sur l?internet concernant l?enseignement
de la médecine est en croissance permanente. Il devient de plus en
plus difficile, pour l?étudiant comme pour l?enseignant, de repérer
des documents de qualité et répondant à une question précise. CISMeF
et son outil de recherche associé Doc?CISMeF, permettent de répondre
à cette attente. Ils sont fondés sur un modèle d?information qui
intègre les mots-clés et les qualificatifs du thesaurus MeSH et y
adjoint deux concepts supplémentaires avec les métatermes et les
types de ressources. La réalisation du catalogue s?appuie sur une
sélection rigoureuse des ressources notamment au regard de critères
de qualité stricts (grille de critères du NetScoring et langage de
métadonnées HIDDEL). Plusieurs modes de recherche sont proposés.
La recherche « avancée » permet des requêtes élaborées, pouvant combiner
plusieurs champs grâce aux opérateurs booléens ET, OU, SAUF. Doc?CISMeF
a été choisi pour être un des outils de recherche de l?Université
Médicale Virtuelle Francophone (UMVF).
BibTeX:
@article{Magaly2003,
  author = {Douyère, M and Thirion, B and Leroy, JP and Dahamna, B and Darmoni, SJ},
  title = {Doc'CISMEF : un outil de recherche Internet dirigé vers l'enseignement de la médecine.},
  journal = {Document Numérique},
  year = {2003},
  volume = {7},
  number = {1-2},
  pages = {129-140},
  note = {Numéro Spécial "Document et éducation" sous la direction de Christine Vanoirbeek et Omar Abou Khaled},
  url = {http://www.cairn.info/revue-document-numerique-2003-1-p-129.htm}
}

BibTeX:
@phdthesis{Lefebvre2003b,
  author = {Lefebvre, A},
  title = {Une nouvelle heuristique pour la d\'etection de r\'ep\'etitions sur des g\'enomes complets, pour la comparaison de g\'enomes et pour la compression},
  school = {Universit\'e de Rouen, France},
  year = {2003}
}

BibTeX:
@inproceedings{Beuscart-Zephir2003,
  author = {Beuscart-Zephir, MC and Leroy, N and Watbled, L and Guerlinger, S and Wascat, C and Darmoni, SJ},
  title = {Evaluation de l'utilisabilité d'un site francophone de resources médicales en ligne : l'exemple de CISMeF},
  booktitle = {JFIM, 9èmes Journées Francophone d?Informatique Médicale},
  address = {Québec, Canada},
  month = {Mai},
  year = {2003},
  url = {http://www.univ-lille2.fr/evalab/publisPDF/31%20mcbz%20JFIM%202002.pdf}
}

BibTeX:
@inproceedings{SJ.2003,
  author = {Darmoni, SJ and THIRION, B. and POURCHEZ, B and WEBER, J},
  title = {Use of Information and Communication Technologies to retrieve French pre-Residency Examination Program teaching resources on the Internet.},
  booktitle = {MIE},
  year = {2003},
  url = {http://www.med.univ-rennes1.fr/resped/s/mie/CISMeFInternat%20MIE%202003.ppt}
}

Abstract: A considerable number of robust vocabularies and thesauri have been
developed for the healthcare and biomedical domain. No single vocabulary,
however; provides complete coverage of the information needs from
a public health perspective. The results of an investigation of vocabulary
sources for the development of a comprehensive controlled vocabulary
for the public health domain at the Centers for Disease Control and
Prevention (CDC) is presented.
BibTeX:
@article{Darmoni2003,
  author = {Darmoni, S. J. and Jarrousse, E. and Zweigenbaum, P. and Le Beux, P. and Namer, F. and Baud, R. and Joubert, M. and Vallée, H. and R. Côté, A. and Buemi, A. and Bourigault, D. and Recource, G. and Jeanneau, S. and Rodrigues, J. M.},
  title = {VUMeF: extending the French involvement in the UMLS Metathesaurus.},
  journal = {AMIA Annu Symp Proc},
  school = {L@STICS, PSI fRE CNRS 2645.},
  year = {2003},
  pages = {824},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1480335}
}

Abstract: This study examines an enabling condition for natural languages access
to medical knowledge resources (Medline, CISMeF) indexed with controlled
vocabularies (e.g., the MeSH): is the vocabulary of user queries
comparable with that of the index terms? The two vocabularies were
compared in their original form, then under incrementally normalized
forms, using character-based normalizations then linguistic normalizations.
Only 16.7% of the user vocabulary, in its original form, is in the
MeSH. Progressive normalizations increase this proportion to 65.5%.
Besides, if the frequencies of occurrence of words are taken into
account, 89.3% of user word occurrences can be matched to MeSH words.
This shows the interest of taking into account further matching methods
between queries and index terms than those presented here.
BibTeX:
@article{Grabar2003,
  author = {Grabar, Natalia and Zweigenbaum, Pierre and Soualmia, Lina and Darmoni, Stéfan},
  title = {Matching controlled vocabulary words.},
  journal = {Stud Health Technol Inform},
  school = {STIM/DSI, Assistance Publique-Hôpitaux de Paris, France. ngr@biomath.jussieu.fr},
  year = {2003},
  volume = {95},
  pages = {445--450}
}

Abstract: We describe MedCIRCLE, an EU-funded semantic web project to implement
the first steps towards a global, collaborative rating and guidance
system for health information proposed in the MedCERTAIN project.
In MedCIRCLE, three European gateway sites for consumer health information
will implement the metadata vocabulary HIDDEL (Health Information
Disclosure, Description and Evaluation Language). HIDDEL allows portals
and gateways to make the results of their evaluations accessible
as XML/RDF. The three participating national portals are: AQUMED
(Agency for Quality in Medicine) patienten-information, de, COMB
(Official Medical College of Barcelona) and CISMeF, a quality-controlled
health gateway developed at Rouen University Hospital. Other health
subject gateways, accreditation, or rating services are invited to
join the collaboration simply by implementing HIDDEL on their gateways.
Widespread implementation HIDDEL will allow intelligent agents or
client-side software to harvest statements and opinions about the
trustworthiness of other websites, assisting users in selecting trustworthy
websites. The MedCIRCLE project builds on, expands and continues
work on rating health information on the Internet piloted within
the MedCERTAIN project. While MedCERTAIN provided the core technologies
and software for rating and "trustmarking" health information, MedCIRCLE
is built around these technologies and involves a wider medical community
to assess health information, demonstrating the power of collaborative
and interoperable evaluations in a semantic web environment. MedCIRCLE
is a project with the overall objective to develop and promote technologies
able to guide consumers to trustworthy health information on the
Internet, to establish a global web of trust for networked health
information, and to empower consumers to positively select high quality
health information on the web. Other aims include refinement and
expansion of HIDDEL, to become a standard vocabulary and interchange
format for self- and third-party ratings of health information.
BibTeX:
@article{Mayer2003,
  author = {Mayer, M. A. and Darmoni, S. J. and Fiene, M. and Köhler, C. and Roth-Berghofer, Thomas R and Eysenbach, G},
  title = {MedCIRCLE: collaboration for Internet rating, certification, labelling and evaluation of health information on the World-Wide-Web.},
  journal = {Stud Health Technol Inform},
  school = {Web Médica Acreditada, WMA, Official Medical Association of Barcelona, Spain.},
  year = {2003},
  volume = {95},
  pages = {667--672}
}

BibTeX:
@inproceedings{A.2003,
  author = {NEVEOL, A. and SOUALMIA, LF. and ROGOZAN, A. and DOUYERE, M. and Darmoni, SJ.},
  title = {Utilisation des propriétés sémantiques de la terminologie CISMeF pour la catégorisation de ressources de santé.},
  booktitle = {JFIM},
  year = {2003},
  url = {http://aurelie.neveol.free.fr/NeveolJFIM03.pdf}
}

Abstract: This paper is positioned within the development of an automated indexing
system for the CISMeF quality controlled health gateway. For disambiguation
purposes, we wish to perform text categorization prior to indexing.
Hence, a global approach contrasting with the classical analytical
methods based on the analysis of keyword counts extracted from the
text is necessary. The use of statistical compression models enables
us to proceed avoiding keyword extraction at this stage. Preliminary
results show that althought this method is not as precise as others
in terms of resource categorization, it can significantly benefit
indexing.
BibTeX:
@inproceedings{Rogozan2003,
  author = {Rogozan, A. and Neveol, A. and Darmoni, S. J.},
  title = {Text Categorization prior to Indexing for the CISMEF Health Catalogue},
  booktitle = {Artificial Intelligence in Medicine: 9th Conference on Artificial Intelligence in Medicine in Europe, AIME 2003},
  address = {Protaras, Cyprus},
  month = {October},
  publisher = {Springer},
  year = {2003},
  volume = {2780},
  pages = {81-85},
  url = {http://aurelie.neveol.free.fr/RogozanAIME03.pdf},
  doi = {10.1007/b12009}
}

Abstract: This paper deals with the problem of information retrieval on the
Web and present the CISMeF project (acronym of Catalogue and Index
of French-speaking Medical Sites). Information retrieval in the CISMeF
catalogue is done with a terminology that is similar to ontology
of medical domain and a set of metadata. This allows us to place
the project at an overlap between the present Web, which is informal,
and the forthcoming Semantic Web. We also describe an ongoing work,
which consists of applying thr ee knowledge-based methods in order
to enhance information retrieval.
BibTeX:
@inproceedings{LF.2003c,
  author = {SOUALMIA, LF and BARRY, C. and Darmoni, SJ.},
  title = {Knowledge-Based Query Expansion over a Medical Terminology Oriented Ontology.},
  booktitle = {Artificial Intelligence in Medicine: 9th Conference on Artificial Intelligence in Medicine in Europe, AIME 2003},
  year = {2003},
  url = {http://www.springerlink.com/content/qlatdrljyd51a8dh}
}

BibTeX:
@inproceedings{SOUALMIA2003,
  author = {SOUALMIA, L and DARMONI, SJ},
  title = {Etude du web sémantique : vers une recherche d?information intelligente en santé.},
  booktitle = {JFIM},
  year = {2003}
}

Abstract: The amount of health data accessible on the Web is increasing and
Internet has become a major source of health information. Many tools
and search engines are available but medical information retrieval
remains difficult for both the health professional and the patients.
In this paper we describe CISMeF-patients. It is a sub-part of CISMeF,
a structured quality-controlled subject gateway. CISMeF-patients
has been designed for the patients, their families and the general
public who are often unfamiliar with the medical domain and the medical
vocabulary. The resources included in CISMeF-patients are described
using the Dublin Core metadata format. To index them, CISMeF-patients
and CISMeF share the same terminology, which 'encapsulates' the MeSH
thesaurus with a layer of synonyms. Unlike Medline-plus and Medline,
sharing the same terminology allows to a CISMeF-patients end-user
the possibility to extend his query to the CISMeF catalogue (e.g.
for searching teaching resources or clinical guidelines).
BibTeX:
@article{Soualmia2003,
  author = {Soualmia, Lina F and Darmoni, Stéfan J and Douyère, Magaly and Thirion, Benoît},
  title = {Modelisation of consumer health information in a quality-controlled gateway.},
  journal = {Stud Health Technol Inform},
  school = {Network Department, Rouen University Hospital, 76031 Rouen, France. lina.soualmia@chu-rouen.fr},
  year = {2003},
  volume = {95},
  pages = {701--706}
}

Abstract: BACKGROUND: Quality-controlled subject gateways are Internet services
which apply a selected set of targeted measures to support systematic
resource discovery. Considerable manual effort is used to process
a selection of resources which meet quality criteria and to display
a extensive description and indexing of these resources with standards-based
metadata. OBJECTIVE: Several metadata element sets are proposed to
describe, index and quality health resources to be included in a
French quality-controlled health gateway called CISMeF. The main
objectives were to enhance Internet health document retrieval and
navigation, and to allow interoperability with other Internet services.
RESULTS: The Dublin Core metadata element set is used to describe
and index all Internet health resources included in CISMeF. For teaching
resources, some elements from IEEE1484 Learning Object Metadata are
also used. For evidenced-base medicine resources, specific metadata
are employed which assess the health content quality. The HIDDEL
metadata set is used to enhance transparency, trust and quality of
health information on the Internet. CONCLUSION: Comprehensive metadata
element sets can be extremely useful to describe, index and assess
health resources on the Internet in a quality-controlled subject
gateway. Machine-readable metadata creates an Semantic Web which
is more efficient for end-users as compared to the current Web.
BibTeX:
@article{Thirion2003,
  author = {Thirion, Benoit and Loosli, Gaelle and Douyère, Magaly and Darmoni, Stéfan J},
  title = {Metadata element set in a quality-controlled subject gateway: a step to a health semantic Web.},
  journal = {Stud Health Technol Inform},
  school = {Medical School, France. Stefan.Darmoni@chu-rouen.fr},
  year = {2003},
  volume = {95},
  pages = {707--712}
}

Abstract: Lexical resources for medical language, such as lists of words with
inflectional and derivational information, are publicly available
for the English lantuate with the UMLS Specialist Lexicon. The goal
of the UMLF project is to pool and unify existing resources and to
add extensively to them by exploiting medical terminologies and corpora,
resulting in a Unified Medical Lexicon for French. We present here
the current status of the project.
BibTeX:
@article{Zweigenbaum2003,
  author = {Pierre Zweigenbaum and Robert Baud and Anita Burgun and Fiammetta Namer and Eric Jarrousse and Natalia Grabar and Patrick Ruch and Franck Le Duff and Benoît Thirion and Stéfan Darmoni},
  title = {UMLF: a Unified Medical Lexicon for French.},
  journal = {AMIA Annu Symp Proc},
  school = {STIM/DSI, Assistance Publique - Hôpitaux de Paris, France.},
  year = {2003},
  pages = {1062},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1480196}
}

Abstract: Medical Informatics has a constant need for basic Medical Language
Processing tasks, e.g., for coding into controlled vocabularies,
free text indexing and information retrieval. Most of these tasks
involve term matching and rely on lexical resources: lists of words
with attached information, including inflected forms and derived
words, etc. Such resources are publicly available for the English
language with the UMLS Specialist Lexicon, but not in other languages.
For the French language, several teams have worked on the subject
and built local lexical resources. The goal of the present work is
to pool and unify these resources and to add extensively to them
by exploiting medical terminologies and corpora, resulting in a unified
medical lexicon for French (UMLF). This paper exposes the issues
raised by such an objective, describes the methods on which the project
relies and illustrates them with experimental results.
BibTeX:
@article{Zweigenbaum2003a,
  author = {Pierre Zweigenbaum and Robert Baud and Anita Burgun and Fiammetta Namer and Eric Jarrousse and Natalia Grabar and Patrick Ruch and Franck Le Duff and Benoît Thirion and Stéfan Darmoni},
  title = {Towards a unified medical lexicon for French.},
  journal = {Stud Health Technol Inform},
  school = {STIM/DSI, Assitance Publique-Hôpitaux de Paris, France. pz@biomath.jussieu.fr},
  year = {2003},
  volume = {95},
  pages = {415--420}
}

BibTeX:
@inproceedings{P.2003,
  author = {ZWEIGENBAUM, P and BAUD, R and BURGUN, A and NAMER, F and JAROUSSE, E and GRABAR, N and RUCH, P and LE DUFF, F and THIRION, B and Darmoni, SJ.},
  title = {UMLF : construction d?un lexique médical francophone unifié.},
  booktitle = {JFIM},
  year = {2003},
  url = {http://estime.spim.jussieu.fr/~pz/FTPapiers/Zweigenbaum:JFIM2003.pdf}
}

BibTeX:
@inproceedings{SJ.2003a,
  author = {Darmoni, SJ and Douyère, M and Hamon, A and Benichou, J and Weber, J},
  title = {Evaluation d'un catalogue de santé pour diffuser des ressources pédagogiques sur l'Internet : une étude randomisée.},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Marseille, France},
  year = {2003}
}

BibTeX:
@inproceedings{J.2003,
  author = {Ladner, J and Douyère, M and Tavolacci, MP and Darmoni, SJ and Coutour, X and Czernichow, P},
  title = {La formation en santé publique à portée d'un clic : un essai à transformer ?},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Marseille, France},
  year = {2003}
}

Abstract: L?information accessible sur la Toile (ou Web) est disponible en quantité
importante et elle ne cesse de croître. La recherche d?information
demeure problématique malgré l?existence de nombreux moteurs de recherche
et de sites catalogues en ligne. Le Web doit faire face aux problèmes
d?exhaustivité et de précision en recherche d?information. Le projet
CISMeF (Catalogue et Index de Sites Médicaux Francophones) a été
développé afin de faciliter l?accès à l?information de santé disponible
sur l?Internet. La problématique d?aujourd?hui se veut aussi être
une recherche d?information intelligente dans l?infrastructure du
Web Sémantique, une extension du web actuel qui permettrait de rendre
interprétable le contenu des ressources par les hommes mais aussi
par les machines, grâce à des ontologies et des méta-données. La
recherche d?information dans CISMeF se fait à l?aide d?une terminologie
semblable à une ontologie et un ensemble de méta-données qui nous
permettent de placer le projet à cheval entre le Web actuel qui est
informel, et le Web Sémantique de demain.
BibTeX:
@inproceedings{LF.2003a,
  author = {SOUALMIA, LF and Darmoni, SJ.},
  title = {Une Terminologie Orientée Ontologie pour la Recherche d'Information sur la Toile.},
  booktitle = {JFT},
  year = {2003},
  pages = {185-194},
  url = {http://www.antsearch.univ-tours.fr/jft2003/file/ActesJFT2003.pdf}
}

BibTeX:
@inproceedings{LF.2003b,
  author = {SOUALMIA, LF and Darmoni, SJ.},
  title = {Projection de Requêtes pour une Recherche d'Information Intelligente sur le Web.},
  booktitle = {RJCIA (Rencontres Jeunes Chercheurs en Intelligence Artificielle)},
  address = {Laval, France},
  month = {Juillet},
  year = {2003},
  url = {http://afia.lri.fr/plateforme-2003/Articles/RJCIA/rjcia-05-Soualmia.pdf}
}

BibTeX:
@inproceedings{LF.2003,
  author = {SOUALMIA, LF and Néveol, A and DAHAMNA, B and DOUYERE, M and LEROY, JP and THIRION, B and Darmoni, SJ.},
  title = {CISMeF dans l'infrastructure du Web Sémantique.},
  booktitle = {Premier Séminaire du Web Sémantique Médical},
  address = {Rennes, France},
  year = {2003},
  url = {http://aurelie.neveol.free.fr/SoualmiaWSM03.pdf}
}

BibTeX:
@inproceedings{TD2003,
  author = {Tran, TD and Mougin, F and Darmoni, SJ and Le Beux, P},
  title = {Indexation semi-automatique conceptuelle des cours de médecine de l'Université Médicale Virtuelle Francophone (UMVF).},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Marseille, France},
  year = {2003}
}

BibTeX:
@inproceedings{C.2003,
  author = {WASCAT, C and LEROY, N and BEUSCART-ZEPHIR, MC and ANCEAUX, F and Darmoni, SJ.},
  title = {Evaluation du niveau de difficulté rencontrée par les utilisateurs face à un moteur de recherche médical : l?exemple de Doc?CISMeF.},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Marseille, France},
  year = {2003}
}

BibTeX:
@inproceedings{P.2003a,
  author = {ZWEIGENBAUM, P and Darmoni, SJ and CRACIUN, A and JACQUEMART, P and SOUALMIA, LF},
  title = {Questions réponses dans le domaine médical.},
  booktitle = {Journées d'Étude de l'Association pour le Traitement Automatique des LAngues (ATALA)},
  address = {Paris, France},
  month = {mai},
  year = {2003}
}

2002


Abstract: OBJECTIVES: We have developed a RESOURCE SERVER to collect and store
various elements used by a professor during his lecture. METHODS:
The server manages four types of objects: ELEMENTS, RESOURCES (set
of elements referring to a given topic), INDEXES (to organize the
resources for further search and use), and USERS (to identify providers,
users, and access rights). If an ELEMENT s modified, the RESOURCE
is automatically updated. RESULTS: An example (preparation of an
anatomy lecture) explains how the RESOURCE SERVER works in three
steps: organization of the training material, indexing, and retrieval.
CONCLUSIONS: The RESOURCE SERVER will help instructors develop, update
and share pedagogic resources for supporting their training courses,
lessons and conferences. Moreover, these techniques, based on Internet
technologies for easy handling of and access to these resources,
allow local and distant access. Within the general framework of the
French-speaking Virtual Medical University, the RESOURCE SERVER will
represent an important link between data collection and its use in
intelligent pedagogic training.
BibTeX:
@article{Brunetaud2002,
  author = {J. M. Brunetaud and S. Darmoni and N. Souf and E. Dufresne and R. Beuscart},
  title = {A resource server for medical training.},
  journal = {Methods Inf Med},
  school = {Centre d'Etude et de Recherche en Informatique Médicale, Faculté de Médecine de Lille, France. jmbrunetaud@univ-lille2.fr},
  year = {2002},
  volume = {41},
  number = {2},
  pages = {177--182}
}

BibTeX:
@article{Darmoni2002,
  author = {Stéfan Darmoni and Benoit Thirion and Sylvie Platel and Magsly Douyère and Philippe Mourouga and Jean-Philippe Leroy},
  title = {CISMeF-patient: a French counterpart to MEDLINEplus.},
  month = {Apr},
  journal = {J Med Libr Assoc},
  school = {Computing Department, Centre Hospitalier Universitaire de Rouen, INSA de Rouen, France. stefan.darmoni@chu-rouen.fr},
  year = {2002},
  volume = {90},
  number = {2},
  pages = {248--253},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=100773}
}

BibTeX:
@article{Darmoni2002b,
  author = {Stefan J Darmoni and Francis Roussel and Jacques Benichou and Benoit Thirion and Nicole Pinhas},
  title = {Reading factor: a new bibliometric criterion for managing digital libraries.},
  month = {Jul},
  journal = {J Med Libr Assoc},
  school = {Computer and Networks Department, Rouen Medical School, France. stefan.darmoni@chu-rouen.fr},
  year = {2002},
  volume = {90},
  number = {3},
  pages = {323--327},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=116406}
}

BibTeX:
@article{Thirion2002a,
  author = {Thirion, B and Robu, I},
  title = {Too many discussion lists for health sciences librarians?},
  journal = {EAHIL Newsletter to European Health Librarians},
  year = {2002},
  volume = {58},
  pages = {10-11},
  url = {http://www.eahil.net/newsletter/58/feb2002.pdf}
}

BibTeX:
@article{SJ.2002,
  author = {Darmoni, SJ and Mayer, MA and Thomeczek, C and Eysenbach, G},
  title = {Qualité de l'information : le projet MedCIRCLE.},
  month = {Mai},
  journal = {Revue du Praticien - Médecine Générale},
  year = {2002},
  volume = {16},
  number = {576},
  pages = {851-852}
}

BibTeX:
@article{Gehanno2002b,
  author = {Gehanno, JF},
  title = {L'Internet, facteur de changement des pratiques en santé au travail ?},
  journal = {Archives des Maladies Professionnelles},
  year = {2002},
  volume = {63},
  number = {3-4},
  pages = {261-267},
  url = {http://www.em-consulte.com/article/72546}
}

BibTeX:
@inproceedings{MA.2002,
  author = {MA. Mayer and SJ. Darmoni and M. Fiene and G. Eysenbach and R. Sarrias and C. Köhler and Thomas R and Roth-Berghofer and M. Gelabert.},
  title = {Información de Calidad en Internet: proyecto MedCIRCLE.},
  booktitle = {Informed 2002 IX Congreso Nacional de Informática Médica},
  address = {Valencia},
  month = {Nov},
  year = {2002},
  url = {http://wma.comb.es/Upload/Documents/MedCIRCLE_Informed2002.pdf}
}

BibTeX:
@article{Nicolas2002a,
  author = {Nicolas, D and Boulard, P and Boitel, L and Muller, F and Gehanno, JF},
  title = {Internet et services médicaux interentreprises : bilan d'une enquête sur 287 Services interentreprises de Médecine du travail.},
  journal = {Archives des Maladies Professionnelles},
  year = {2002},
  volume = {63},
  number = {3-4},
  pages = {261-267},
  url = {http://www.em-consulte.com/article/72548}
}

Abstract: We present here the usability assessment study of a medical web site
dedicated to the Cataloguing and Indexing of French speaking Medical
web Sites (http://www.cismef.org). We performed a usability inspection
using heuristic evaluation and an empirical usability test using
a portable lab. From these results, we draw up a set of recommendations
for the re-engineering of the Human Computer Interface (HCI). We
conclude on the necessity to integrate usability engineering early
enough in the projects lifecycle.
BibTeX:
@inproceedings{BEUSCART2002,
  author = {BEUSCART, MC and LEROY, N and WASCAT, C and DARMONI, SJ},
  title = {Usability Study of a Medical Resources Web Site},
  booktitle = {Methods for User's Behaviour Monitoring.. Human Factors \& the Web : Designing and Evaluating for the Web.},
  address = {Nice, France},
  month = {March},
  year = {2002},
  url = {http://psimail.insa-rouen.fr/MnemosNet/psipubli.nsf/cc186bfe393798efc1256cc70057d255/2a695bd953199c66c1256b7a0031f123/$FILE/mcbeuscartzephir%20HFand%20the%20web2002%20.doc}
}

Abstract: We present here the usability assessment study of a medical web site
dedicated to the Cataloguing and Indexing of French speaking Medical
web Sites (CISMeF). We performed a usability inspection using heuristic
evaluation and an empirical usability test using a portable lab.
The results of the heuristic evaluation show usability flaws along
guidance, prompting and legibility ergonomic criteria. The usability
test confirms this result and gives some more hints about the severity
rating of the problems. From these results, we draw up a set of recommendations
for the re-engineering of the Human Computer Interface (HCI). We
conclude on the necessity to integrate usability engineering early
enough in the projects lifecycle.
BibTeX:
@article{Beuscart-Zephir2002,
  author = {Marie-Catherine Beuscart-Zéphir and Nicolas Leroy and Omolade Alao and Stefan Darmoni},
  title = {Usability assessment study of a web site displaying medical resources on line: the CISMeF.},
  journal = {Stud Health Technol Inform},
  school = {CERIM-EVALAB, Faculté de Médecine, Lille, France. mcbeuscart@univ-lille2.fr},
  year = {2002},
  volume = {90},
  pages = {133--137}
}

BibTeX:
@inproceedings{SJ.2002a,
  author = {Darmoni, SJ and AMSALLEM, E and HAUGH, MC and DOUYERE, M and THIRION, B and WEBER, J and BOISSEL, JP},
  title = {Indication du niveau preuve : critère de qualité du contenu de l?information de santé sur l?Internet.},
  booktitle = {JFIM},
  address = {Québec, Canada},
  year = {2002},
  pages = {245-254}
}

Abstract: BACKGROUND: Constant assessment of the quality of health information
on the Internet is an absolute necessity as peer review is often
lacking in this media. OBJECTIVE: To develop a simple and easy French
Code of Ethics, which will enable medical students to judge quality
of health information in teaching material available on the Internet.
DESIGN: Three medical informaticians selected ten criteria from previously
established codes of ethics from Europe and the USA. This instrument
was tested on a sample of 30 health Internet teaching resources.
RESULTS: For the panel of experts, chance corrected inter-observer
agreement (kappa) for quality rating ranged from k = -0.19 and k
= 0.33, demonstrating poor agreement among the raters. CONCLUSION:
If negative results of this preliminary study are confirmed by further
research, this finding may detrimentally affect projects in Europe
to accredit or certify Internet health resources.
BibTeX:
@inproceedings{Darmoni2002c,
  author = {S. J. Darmoni and F. Le Duff and M. Joubert and P. Le Beux and M. Fieschi and J. Weber and J. Benichou},
  title = {Assessment of a French code of ethics for health teaching resources on the Internet. (Poster)},
  booktitle = {Proc. AMIA Symp.},
  school = {Medical School, Rouen University, France.},
  year = {2002},
  pages = {1017}
}

Abstract: Constant assessment of the quality of health information on the Internet is an absolute necessity as peer review is often lacking in this media. To develop a simple and easy French Code of Ethics, which will enable medical students to judge quality of health information in teaching material available on the Internet. Three medical informaticians selected ten criteria from previously established codes of ethics from Europe and the USA. This instrument was tested on a sample of 30 health Internet teaching resources. For the panel of experts, chance corrected inter-observer agreement (kappa) for quality rating ranged from k = -0.19 and k = 0.33, demonstrating poor agreement among the raters. If negative results of this preliminary study are confirmed by further research, this finding may detrimentally affect projects in Europe to accredit or certify Internet health resources.
BibTeX:
@article{Darmoni2002a,
  author = {Darmoni, S J and Le Duff, F and Joubert, M and Le Beux, P and Fieschi, M and Weber, J and Benichou, J},
  title = {A preliminary study to assess a French code of ethics for health teaching resources on the Internet.},
  journal = {Studies in health technology and informatics},
  year = {2002},
  volume = {90},
  pages = {621--626},
  note = {21 refs., KIE Bib: biomedical technologies; health care}
}

BibTeX:
@inproceedings{Gehanno2002a,
  author = {Gehanno, JF.},
  title = {Use of Internet Among Occupational Health Practitioners in France.},
  booktitle = {6th International Conference of the Scientific Committee on Education and Training in Occupational Health, ICOH},
  address = {Baltimore, USA},
  month = {October},
  year = {2002}
}

BibTeX:
@inproceedings{GRABAR2002a,
  author = {GRABAR, N and ZWEIGENBAUM, P and SOUALMIA, LF and Darmoni, SJ.},
  title = {A Study of the Adequacy of User and Indexing Vocabularies in Natural Language Queries to a MeSH-Indexed Health Gateway.},
  booktitle = {Proc AMIA Symp.},
  year = {2002},
  pages = {1029},
  url = {http://estime.spim.jussieu.fr/~pz/FTPapiers/Grabar:AMIA2002.pdf}
}

BibTeX:
@inproceedings{Grabar2002,
  author = {Grabar, N. and Zweigenbaum, P. and Soualmia, L. and Darmoni, S. J.},
  title = {Les utilisateurs de Doc'CISMeF peuventils trouver ce qu'ils cherchent? Une étude de l'adéquation du vocabulaire des requêtes des utilisateurs au MeSH},
  booktitle = {JFIM},
  address = {Québec Canada},
  month = {Mai},
  publisher = {JFIM},
  year = {2002},
  pages = {158-169}
}

BibTeX:
@inproceedings{C.2002,
  author = {C. Köhler and SJ. Darmoni and MA. Mayer and TR. Roth-Berghofer and M. Fiene and G. Eysenbach.},
  title = {MedCIRCLE - The Collaboration for Internet Rating, Certification, Labelling, and Evaluation of Health Information.},
  booktitle = {Mednet 2002, World Congress of the Internet in Medicine},
  address = {Amsterdam, The Netherlands},
  month = {december},
  year = {2002},
  url = {http://www.mednet2002.org/abstracts/display.cfm?id=104184401}
}

Abstract: French pharmaceutical theses are rarely quoted. If the main obstacles
originate from language or access barriers, proper indexation could
also be blamed. Manually extracted key-words don't necessary come
from a structured thesaurus. In the following work, this manual indexing
method is compared to an automated one, "Nomindex", based on UMLS.
The automated method is improved by the addition of a relevance scoring
system. The first indexing step consists of downloading, adapting
and indexing theses in electronic format. Results will then be analyzed
and sorted by relevance, through the comparison of classic statistical
indices (noise, silence and relevance). It was assumed that the manually
obtained key-words were always relevant. The silence of manual indexing
is nevertheless high: seven new key-words are proposed by Nomindex,
which results are mixed (10% of silence, but 50% of noise). These
results are promising on the first experiment on pharmaceutical document
without lexicon improvement. The indexing, if it is currently insufficient
for a real life use, could easily be improved by specific updates
of the lexicon.
BibTeX:
@article{Mary2002,
  author = {Vincent Mary and Bruno Pouliquen and Franck Le Duff and Stefan J Darmoni and Alain Segui and Pierre Le Beux},
  title = {Automatic conceptual indexing of French pharmaceutical theses.},
  journal = {Stud Health Technol Inform},
  school = {Laboratoire d'informatique médicale, Faculté de Médecine, Rennes, France.},
  year = {2002},
  volume = {90},
  pages = {388--392},
  url = {http://langtech.jrc.it/Documents/MIE-02_Vincent.pdf}
}

BibTeX:
@inproceedings{Mary2002a,
  author = {Mary, V and Pouliquen, B and Le Duff, F and Darmoni, SJ and Segui, A and Le Beux, P},
  title = {Indexation automatique conceptuelle de thèses pharmaceutiques françaises.},
  booktitle = {JFIM},
  address = {Québec, Canada},
  month = {Mai},
  year = {2002}
}

BibTeX:
@inproceedings{M2002,
  author = {SOUALMIA, LF and DARMONI, SJ and DOUYERE, M and LE DUFF, F and THELWALL, M},
  title = {Web Impact Factor: un outil bibliométrique appliqué aux sites Web des facultés de médecine et des CHU français},
  booktitle = {JFIM},
  address = {Québec, Canada},
  month = {Mai},
  year = {2002},
  pages = {496}
}

Abstract: Several methods are available to evaluate and compare medical journals.
The most popular is the journal Impact Factor, derived from averaging
counts of citations to articles. Ingwersen adapted this method to
assess the attractiveness of Web sites, defining the external Web
Impact Factor (WIF) to be the number of external pages containing
a link to a given Web site. This paper applies the WIF to 43 medical
informatics societies' Web sites using advanced search engine queries
to obtain the necessary link counts. The WIF was compared to the
number of publications available in the Medline bibliographic database
in medical informatics in these 43 countries. Between these two metrics,
the observed Pearson correlation was 0.952 (p < 0.01) and the Spearman
rank correlation was 0.548 (p < 0.01) showing in both cases a positive
and strong significant correlation. The WIF of medicalm informatics
society's Web site is statistically related to national productivity
and discrepancies can be used to indicate countries where there are
either weak medical informatics associations, or ones that do not
make optimal use of the Web.
BibTeX:
@article{Soualmia2002,
  author = {Lina Fatima Soualmia and Stéfan Jacques Darmoni and Franck Le Duff and Magaly Douyere and Maurice Thelwall},
  title = {Web impact factor: a bibliometric criterion applied to medical informatics societies' web sites.},
  journal = {Stud Health Technol Inform},
  school = {Computer and Networks Department, Rouen University Hospital, France.},
  year = {2002},
  volume = {90},
  pages = {178--183}
}

Abstract: In cyberspace, the health webmaster could be regarded as a virtual
editor-in-chief, in charge of content and design. In this circumstance,
he/she must follow quality criteria when building any resource. At
the Rouen University Hospital (RUH), we have chosen "Net Scoring"
as an effective tool to aid the design of a quality Web site. "Net
Scoring" contains a list of 49 criteria which fall into eight categories:
credibility, content, links, design, interactivity, quantitative
aspects, ethics, and accessibility. The webmaster is the key element
of the editorial board process. He/she must regularly monitor the
Web site in order to retrieve information about whether the site
is used and by whom: the method most commonly used is log analysis.
At the RUH, an average of 9,000 unique machines visit our Web site
each working day. Webmaster is a new job opportunity in academic
institutions, in particular for medical informaticians and medical
librarians both whom are information science professionals.
BibTeX:
@article{Thirion2002,
  author = {Benoit Thirion and Stéfan Jacques Darmoni and Magaly Douyere and Jean-Philippe Leroy},
  title = {Webmastering in academic institutions: a new job opportunity.},
  journal = {Stud Health Technol Inform},
  school = {Medical Library, Rouen University Hospital, 1 rue Germont F76031 Rouen, France.},
  year = {2002},
  volume = {90},
  pages = {832--837}
}

BibTeX:
@inproceedings{J.2002,
  author = {WEBER, J and Darmoni, SJ},
  title = {French Medical Virtual University.},
  booktitle = {The 10th Ottawa Conference on Medical Education},
  address = {Ottawa, Canada},
  month = {July},
  year = {2002}
}

Abstract: Manually indexed Internet health catalogs such as CliniWeb or CISMeF
provide resources for retrieving high-quality health information.
Users of these quality-controlled subject gateways are most often
referred to them by general search engines such as Google, AltaVista,
etc. This raises several questions, among which the following: what
is the relative visibility of medical Internet catalogs through search
engines? This study addresses this issue by measuring and comparing
the visibility of six major, MeSH-indexed health catalogs through
four different search engines (AltaVista, Google, Lycos, Northern
Light) in two languages (English and French). Over half a million
queries were sent to the search engines; for most of these search
engines, according to our measures at the time the queries were sent,
the most visible catalog for English MeSH terms was CliniWeb and
the most visible one for French MeSH terms was CISMeF.
BibTeX:
@article{Zweigenbaum2002,
  author = {P. Zweigenbaum and S. J. Darmoni and N. Grabar and M. Douyère and J. Benichou},
  title = {An assessment of the visibility of MeSH-indexed medical web catalogs through search engines.},
  journal = {Proc AMIA Symp},
  school = {Département de Biomathématiques, Université Paris 6, Paris, France.},
  year = {2002},
  pages = {954--958}
}

BibTeX:
@inproceedings{P.2002,
  author = {P. Le Beux and B. Kamendje and JM. Brunetaud and AC. Benhamou and SJ. Darmoni and P. Gillois and D. Pagonis and G. Soula and M. Spector and J. Weber.},
  title = {L'Université médicale virtuelle francophone : les réalisations.},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Lille, France},
  year = {2002},
  url = {http://w3med.univ-lille2.fr/ipm2002/programme/resumes.pdf}
}

BibTeX:
@inproceedings{JM.2002,
  author = {JM. Brunetaud and SJ. Darmoni and RENARD JM and F. Le Duff and P. Le Beux and T. FERRE and R. Beuscart.},
  title = {Le rôle d'une plate-forme de télé-enseignement au sein de l'Université Médicale Virtuelle Francophone.},
  booktitle = {Internet et Pédagogie Médicale (IPM) 2001},
  journal = {ormation médicale et Technologies de l'Information et de la Communication, Informatique et Santé},
  year = {2002},
  volume = {14},
  pages = {13-20}
}

BibTeX:
@inproceedings{M.2002,
  author = {M. Cuggia and G. Soula and SJ. Darmoni and F. Mougin and P. Le Beux.},
  title = {Indexation audiovisuelle de l'UMVF : vers une approche web sémantique.},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Lille, France},
  year = {2002},
  url = {http://w3med.univ-lille2.fr/ipm2002/programme/resumes.pdf}
}

BibTeX:
@inproceedings{B.2002,
  author = {B. Dahamna and LF. Soualmia and B. Pourchez and E. Pichon and B. Thirion and J. Weber and SJ. Darmoni.},
  title = {Codage MESH des questions d'internat : intérêt pour Doc'CISMeF, catalogue de ressources pédagogiques},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Lille, France},
  year = {2002},
  url = {http://w3med.univ-lille2.fr/ipm2002/programme/resumes.pdf}
}

BibTeX:
@inproceedings{SJ.2002c,
  author = {SJ. Darmoni and F. Le Duff and JM. Brunetaud and L. SIBERT and A. BURGUN and D. Pagonis and s. ALLORGE and P Le Beux and R. Beuscart and J. Weber.},
  title = {Apprentissage par problème assisté par ordinateur : étude de faisabilité.},
  booktitle = {Internet et Pédagogie Médicale (IPM) 2001},
  journal = {Formation médicale et Technologies de l'Information et de la Communication, Informatique et Santé},
  publisher = {Springer-Verlag France},
  year = {2002},
  volume = {14},
  pages = {45-54}
}

Abstract: Background: An assessment of the quality of health information on
the Internet is an absolute necessity because peer review is often
lacking in this media.

Objective: To develop a simple and easy French code of ethics, which
will enable medical students to judge quality of health information
in teaching material available on the Internet. Design: Three medical
informaticians generated ten criteria from previous codes of ethics
from Europe and the USA. This instrument was tested on a sample of
30 health Internet teaching resources. Results: Chance corrected
inter-observer agreement (kappa) for the quality rating ranged from
k=-0.19 to k=0.33 amongst the expert panel, showing poor agreement
among the raters. Conclusion: If the negative results of this study
are confirmed by further research, they will affect detrimentally
projects in Europe to accredit or certify Internet health resources.
BibTeX:
@inproceedings{DARMONI2002z,
  author = {DARMONI, SJ and LE DUFF, F and JOUBERT, M and LE BEUX, P and FIESCHI, M and WEBER, J and BENICHOU, J},
  title = {Evaluation d'un code d'éthique pour l'étudiant en médecine sur l'Internet},
  booktitle = {Internet et Pédagogie Médicale (IPM) 2001},
  journal = {Formation médicale et Technologies de l'Information et de la Communication, Informatique et Santé},
  year = {2002},
  volume = {14},
  pages = {63-72},
  url = {http://litismail.insa-rouen.fr/MnemosNet/psipubli.nsf/ce6c2c540f564a2dc125680200361b7c/6fbb0ea481fe4ad9c1256b6c003269ef/$FILE/robustesseFR.doc}
}

BibTeX:
@inproceedings{SJ.2002b,
  author = {SJ. Darmoni and MA. Mayer and C. Thomeczek and G. Eysenbach.},
  title = {MEDCIRCLE : un projet européen pour évaluer la qualité de l'information de santé},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Lille, France},
  year = {2002},
  url = {http://w3med.univ-lille2.fr/ipm2002/programme/resumes.pdf}
}

BibTeX:
@inproceedings{Gehanno2002,
  author = {Gehanno, JF.},
  title = {L'Internet, facteur de changement des pratiques en santé au travail ?},
  booktitle = {27eme Congrès National de Médecine et Santé au Travail},
  address = {Grenoble, France},
  month = {Juin},
  year = {2002},
  url = {http://www.federationsantetravail.org/publications/m23Internet.html}
}

BibTeX:
@inproceedings{A.2002,
  author = {Hamon, A and Darmoni, SJ and Le Duff, F and Dufour, JC and Joubert, M and Le Beux, P and Fieschi, M and Weber, J and Bénichou, J},
  title = {Evaluation d'une grille de critères de qualité de ressources pédagogiques disponibles sur l?Internet.},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Lille, France},
  year = {2002},
  url = {http://w3med.univ-lille2.fr/ipm2002/programme/resumes.pdf}
}

BibTeX:
@inproceedings{P.2002b,
  author = {Le Beux, P and Le Duff, F and Soula, G and Brunetaud, JM and Darmoni, SJ and Gillois, P and Pagonis, D and Spector, M and Fieschi, M and Beuscart, R and Degoulet, P and Benhamou, AC and Bonnin, A and Weber, J},
  title = {Définition des spécifications du projet de l'Université Médicale Virtuelle Française},
  booktitle = {Journée AIM 2001},
  address = {Paris, France},
  journal = {Télémédecine et e-santé, Informatique et Santé},
  year = {2002},
  volume = {13},
  pages = {105-112}
}

BibTeX:
@inproceedings{P.2002c,
  author = {Le Beux, P and Le Duff, F and Weber, J and Darmoni, SJ and Benhamou, AC},
  title = {Intégration des Nouvelles Technologies Educatives dans l'Université Médicale Virtuelle Francophone.},
  booktitle = {Internet et Pédagogie Médicale (IPM) 2001},
  journal = {Formation médicale et Technologies de l'Information et de la Communication, Informatique et Santé},
  publisher = {Springer-Verlag France},
  year = {2002},
  volume = {14},
  pages = {3-12}
}

Abstract: The communication of electronic patient records through telecommunication
networks to healthcare professionals between different hospitals
and also between hospitals and family physicians is one of the main
challenges for this decade. In the year 2000, this approach proved
to be successful for communication between three hospitals in Rouen
(France) when used for 966 electronic patient records which contained,
on average, 23 reports in psychiatry, 48 in gastroenterology, and
83 in pneumology. We used a three layer architecture, and security
and confidentiality obligations were fulfilled. This first experience
will be extended to communication between hospitals and family physicians
in the second semester of 2001. A national health patient identification
would facilitate and accelerate the communication of electronic patient
records in France.
BibTeX:
@inproceedings{MASSARI2002,
  author = {MASSARI, P and DARMONI, SJ and FUSS, J and STREIFF, J and ROUSSEL, F.},
  title = {Communication du dossier électronique du patient entre établissements.},
  booktitle = {Journée AIM 2001},
  journal = {Télémédecine et e-santé, Informatique et Santé},
  publisher = {Springer-Verlag France},
  year = {2002},
  volume = {13},
  pages = {11-16},
  url = {http://litismail.insa-rouen.fr/MnemosNet/psipubli.nsf/6584347b5ce03e72c1256b0f007003f0/76659e02f6f8fe86c1256a8b0049864b/$FILE/Article%20AIM_2001_vf.doc}
}

BibTeX:
@inproceedings{Nicolas2002,
  author = {Nicolas, D and Boulard, P and Boitel, L and Muller, F and Gehanno, JF},
  title = {Internet et services médicaux interentreprises : bilan d'une enquête sur 287 Services interentreprises de Médecine du travail.},
  booktitle = {27eme Congrès National de Médecine et Santé au Travail},
  address = {Grenoble, France},
  month = {Juin},
  year = {2002},
  url = {http://www.federationsantetravail.org/publications/m23Internet.html}
}

BibTeX:
@inproceedings{LF.2002,
  author = {LF. SOUALMIA and C. BARRY-GREBOVAL and H. ABDULRAB and Darmoni, SJ.},
  title = {Modélisation et représentation des connaissances dans un catalogue de santé.},
  booktitle = {Treizièmes Journées Francophones d?Ingénierie des Connaissances},
  address = {Rouen, France},
  month = {mai},
  year = {2002}
}

BibTeX:
@inproceedings{LF.2002a,
  author = {LF. SOUALMIA and M. DOUYERE and JP. LEROY and B. THIRION and Darmoni, SJ.},
  title = {Modélisation de l'information dans un catalogue de santé sur l'Internet.},
  booktitle = {Journée "Ingénierie des connaissances et santé"},
  address = {Paris, France},
  month = {28 janvier},
  year = {2002}
}

BibTeX:
@inproceedings{Weber2002,
  author = {J Weber and SJ Darmoni and F Charles and R Bourru},
  title = {Quelle est l'apport des Techniques de l'Information et de la Communication TIC à la pédagogie médicale ?},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Lille, France},
  year = {2002},
  url = {http://w3med.univ-lille2.fr/ipm2002/programme/resumes.pdf}
}

BibTeX:
@inproceedings{P.2002a,
  author = {P. Zweigenbaum and SJ. Darmoni and N. Grabar and M. Douyère and J. Bénichou.},
  title = {Visibilité relative de catalogues web médicaux à travers des moteurs de recherche.},
  booktitle = {Internet et Pédagogie Médicale (IPM)},
  address = {Lille, France},
  year = {2002},
  url = {http://w3med.univ-lille2.fr/ipm2002/programme/resumes.pdf}
}

BibTeX:
@inproceedings{P.2002d,
  author = {ZWEIGENBAUM, P and GRABAR, N and Darmoni, SJ.},
  title = {Projection de requêtes en langue naturelle sur les termes du MeSH : l'apport de connaissances.},
  booktitle = {Internet et Pédagogie Médicale (IPM) 2001},
  journal = {Formation médicale et Technologies de l'Information et de la Communication, Informatique et Santé},
  year = {2002},
  volume = {14},
  pages = {55-62}
}

2001


BibTeX:
@article{Darmoni2001d,
  author = {S. J. Darmoni and M. C. Haugh and B. Lukacs and J. P. Boissel},
  title = {Quality of health information about depression on internet. Level of evidence should be gold standard.},
  month = {Jun},
  journal = {BMJ},
  year = {2001},
  volume = {322},
  number = {7298},
  pages = {1367},
  url = {http://www.bmj.com/cgi/content/full/322/7298/1366#resp1}
}

BibTeX:
@article{Darmoni2001c,
  author = {S. J. Darmoni and B. Thirion and J. P. Leroy and M. Douyère},
  title = {The use of Dublin Core metadata in a structured health resource guide on the internet.},
  month = {Jul},
  journal = {Bull Med Libr Assoc},
  school = {Computer and Networks Department, Rouen University Hospital, France. Stefan.Darmoni@chu-rouen.fr},
  year = {2001},
  volume = {89},
  number = {3},
  pages = {297--301},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=34564}
}

Abstract: In the year 2001, the Internet has become a major source of health
information for the health professional and the Netizen. The objective
of Doc' CISMeF (D'C) was to create a powerful generic search tool
based on a structured information model which 'encapsulates' the
MeSH thesaurus to index and retrieve quality health resources on
the Internet. To index resources, D'C uses four sections in its information
model: 'meta-term', keyword, subheading, and resource type. Two search
options are available: simple and advanced. The simple search requires
the end-user to input a single term or expression. If this term belongs
to the D'C information structure model, it will be exploded. If not,
a full-text search is performed. In the advanced search, complex
searches are possible combining Boolean operators with meta-terms,
keywords, subheadings and resource types. D'C uses two standard tools
for organising information: the MeSH thesaurus and the Dublin Core
metadata format. Resources included in D'C are described according
to the following elements: title, author or creator, subject and
keywords, description, publishers, date, resource type, format, identifier,
and language.
BibTeX:
@article{Darmoni2001,
  author = {S. J. Darmoni and B. Thirion and J. P. Leroy and M. Douyère and B. Lacoste and C. Godard and I. Rigolle and M. Brisou and S. Videau and E. Goupyt and J. Piott and M. Quéré and S. Ouazir and H. Abdulrab},
  title = {A search tool based on 'encapsulated' MeSH thesaurus to retrieve quality health resources on the internet.},
  journal = {Med Inform Internet Med},
  school = {Computer and Networks Department, Rouen University Hospital, France. Stefan.Darmoni@chu-rouen.fr},
  year = {2001},
  volume = {26},
  number = {3},
  pages = {165--178}
}

Abstract: The rapid increase in the price of electronic journals has made the
optimization of collection management an urgent task. As there is
currently no standard procedure for the evaluation of this problem,
we applied the Reading Factor (RF), an electronically computed indicator
used for consultation of individual articles. The aim of our study
was to assess the cost effective impact of modifications in our digital
library (i.e. change of access from the Intranet to the Internet
or change in editorial policy). The digital OVID library at Rouen
University Hospital continues to be cost-effective in comparison
with the interlibrary loan costs. Moreover, when electronic versions
are offered alongside a limited amount of interlibrary loans, a reduction
in library costs was observed.
BibTeX:
@article{Roussel2001,
  author = {F. Roussel and S. J. Darmoni and B. Thirion},
  title = {Cost effectiveness of a medical digital library.},
  journal = {Med Inform Internet Med},
  school = {Department of Histology, Rouen University Hospital, France.},
  year = {2001},
  volume = {26},
  number = {4},
  pages = {325--330},
  url = {http://litismail.insa-rouen.fr/MnemosNet/psipubli.nsf/ce6c2c540f564a2dc125680200361b7c/bd3e3f5dbb12efb0c1256b6c0030d248/$FILE/CAVLMEDINF.doc}
}

BibTeX:
@article{B.THIRION2001,
  author = {THIRION, B and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and Darmoni, SJ.},
  title = {SDI selecting, describing and indexing: did you mean automatically?},
  journal = {Knowledge Organization.},
  year = {2001},
  volume = {28}
}

BibTeX:
@article{SJ2001,
  author = {Darmoni, SJ and Haugh, M and Lukacs, B and Boissel, JP},
  title = {Un nouveau critère de qualité du contenu de santé : le niveau de preuve .},
  journal = {Revue du Praticien - Médecine Générale},
  year = {2001},
  number = {529},
  pages = {479-80}
}

Abstract: Les ressources disponibles sur l'Internet concernant l'enseignement
et la formation dans le domaine de la médecine sont en croissance
exponentielle. L'objectif de Doc'CISMeF est de créer un outil de
recherche générique fondé sur un modèle d'information qui encapsule
le thésaurus MeSH. Pour indexer les ressources de qualité, Doc'CISMeF
utilise 4 niveaux hiérarchiques : métaterme, mot-clé, qualificatif
et type de ressources. Deux recherches sont possibles dans Doc'CISMeF
:- la recherche simple qui permet à l'utilisateur de saisir un terme
ou une expression ; si ce terme appartient à notre modèle d'information,
il sera explosé, c'est-à-dire que Doc'CESMeF affichera toutes les
ressources indexées avec des termes hiérarichiquement inférieurs
; - la recherche avancée permet des requêtes plus complexes, combinant
avec des opérateurs booléens, méta-termes, mots-clés , qualificatifs
et types de ressources, mais aussi tous les champs de Doc'CISMeF,
comme par exemple la cible d'une ressource éducative, notamment le
cycle d'études. Doc'CISMeF utilise deux outils standards pour organiser
l'information le thésaurus MeSH et le format de données et de méta-données
Dublin Core. Les champs de Doc'CISMeF sont: titre, auteur, desciption,
site éditeur, date, identifiant, format, langue, mots-clés et type
de ressources, institution, ville départemen ou province ou état,
pays public concerné, coût, parrainage. Doc'CISMeF est un des outils
de recherche qui sera utilisé au sein de la future Université Médicale
Virtuelle Francophone.
BibTeX:
@article{J.2001,
  author = {DARMONI, SJ and Lacoste, B and Videau, S and LEROY, JP and DOUYERE, M and PIOT, J and Abdulrab, H and THIRION, B},
  title = {Doc' CISMeF : Un "Medline" francophone pour les ressources Internet : Un outil de recherche fonde sur le MeSH.},
  journal = {Médecine d'urgence},
  year = {2001},
  volume = {23},
  number = {HS},
  pages = {279-283}
}

BibTeX:
@article{Stefan2001,
  author = {Stéfan Jacques DARMONI and Jean-Philippe LEROY and Magaly DOUYÈRE and Josette PIOT and Saïda OUAZIR and Benoît LACOSTE and Christophe GODARD and Isabelle RIGOLLE and Martial BRISOU and Stéphane VIDEAU and Myriam QUÉRÉ and Eric GOUPY and Habib ABDULRAB and Benoît THIRION},
  title = {Doc'CISMeF : un outil de recherche Internet orienté vers l'enseignement et la formation à distance en médecine.},
  month = {Août},
  journal = {Pédagogie médicale},
  year = {2001},
  volume = {2},
  number = {3},
  pages = {170-178},
  url = {http://www.pedagogie-medicale.org/2-3-darmoni.pdf}
}

BibTeX:
@article{Gehanno2001,
  author = {Gehanno, JF and Thirion, B and Caillard, JF},
  title = {Approche bibliométrique de la veille documentaire en médecine du travail},
  journal = {Archives des Maladies Professionnelles},
  year = {2001},
  volume = {62}
}

BibTeX:
@inproceedings{B.2001a,
  author = {Thirion, B and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and Darmoni, SJ.},
  title = {Sélection, description, indexation : vous avez dit automatique ?},
  booktitle = {L'indexation à l'ère d'Internet.},
  address = {Lyon, France},
  publisher = {ISKO-France},
  year = {2001},
  pages = {37-32}
}

BibTeX:
@article{B.2001,
  author = {B. Thirion and S. Platel and M. Douyère and P. Mourouga and S. Ouazir and J. Piot and S. Darmoni.},
  title = {CISMeF et la Ligue Nationale contre le Cancer : ensemble pour les patients.},
  month = {Septembre},
  journal = {Revue du Praticien - Médecine Générale},
  year = {2001},
  volume = {15},
  number = {544},
  pages = {1455-6}
}

Abstract: In the year 2000, the Internet became a major source of health information
for the health professional and the Netizen. The objective of Doc'CISMeF
(D'C) was to create a powerful generic search tool based on an structured
information model which â encapsulates' the MeSH thesaurus to index
and retrieve quality health resources on the Internet. To index resources,
D'C uses four sections in its information model: 'meta-term', keyword,
subheading, and resource type. Two search options are available:
simple and advanced. The simple search requires the end-user to input
a single term or expression. If this term belongs to the D'C information
structure model, it will be exploded. If not, a full-text search
is performed. In the advanced search, complex searches are possible
combining Boolean operators with meta-terms, keywords, subheadings
and resource types. D'C uses two standard tools for organising information:
the MeSH thesaurus and the Dublin Core metadata format. Resources
included in D'C are described according to the following elements:
title, author or creator, subject and keywords, description, publisher,
date, resource type, format, identifier, and language.
BibTeX:
@article{Darmoni2001b,
  author = {S. J. Darmoni and B. Thirion and J. P. Leroy and M. Douyère and B. Lacoste and C. Godard and I. Rigolle and M. Brisou and S. Videau and E. Goupy and J. Piot and M. Quéré and S. Ouazir and H. Abdulrab},
  title = {Doc'CISMEF: a search tool based on "encapsulated" MeSH thesaurus.},
  journal = {Medinfo},
  school = {Computer and networks department, Rouen University Hospital, 76031 Rouen, France. Stefan.Darmoni@chu-rouen.fr},
  year = {2001},
  volume = {10},
  number = {Pt 1},
  pages = {314--318}
}

BibTeX:
@inproceedings{P.2001,
  author = {Le Beux, P and Benhamou, AC and Beuscart, R and Bonnin, A and Brunetaud, JM and Darmoni, SJ and DEMONGEOT, J and Fieschi, M and GILLOIS, P and KOHLER, F and Le Duff, F and MORICE, V and Pagonis, D and Spector, M and Soula, G and Weber, J},
  title = {A common platform for French Virtual Medical Universities.},
  booktitle = {Challenges of Primary Care-Oriented Health Systems : Innovations by Educational institutions, Health Professions, and Health Services},
  address = {Londrina, Brazil},
  month = {October},
  year = {2001}
}

Abstract: Among the many bibliometric criteria used to evaluate biomedical journals,
the impact factor is the most commonly used. Despite its limitations,
it quantifies the influence of a journal on secondary publications.
It does not however evaluate the practical usefulness of primary
documents. Usefulness is field-related and varies greatly among specialities.
We introduce a new bibliographic criterion, the "reading factor",
and define it as the ratio between the number of electronic consultations
of a particular journal (i.e., number of clicks on a hyper-link)
and the mean number of electronic consultations of all the journals
studied (itself calculated by dividing the total number of electronic
accesses by the number of journals in the database). We describe
its observed distribution, relative to that of the impact factor,
based on electronic consultation records from our University Hospital
medical digital library, where full-text electronic versions of 45
major biomedical journals have been available since December 1997.
From this analysis we found no correlation between the 1999 reading
factor and the 1998 impact factor of these 45 journals, and we observed
a dramatic change in the hierarchy of journals upon using the reading
factor as the yardstick rather than the impact factor. Moreover,
we describe how using the reading factor has helped in managing the
collection of our University Hospital's virtual library. The selection
of journals to be discarded from the virtual library for the year
2001 was based on journals' RF values and this process will repeated
over the coming years. The reading factor also permits a cost-analysis
of a virtual library. CONCLUSION: The measurement of the reading
factor is highly automated, practical and efficient. It appears as
a new tool for electronic collection management by librarians, well
fitting with economical data.
BibTeX:
@article{Thirion2001,
  author = {B. Thirion and S. J. Darmoni and J. Benichou},
  title = {Reading factor: a bibliometric tool to manage a virtual library.},
  journal = {Medinfo},
  school = {Medical Library, Rouen University Hospital, France.},
  year = {2001},
  volume = {10},
  number = {Pt 1},
  pages = {385--389}
}

Abstract: MeSH-indexed Internet health directories must provide a mapping from
natural language queries to MeSH terms so that both health professionals
and the general public can query their contents. We describe here
the design of lexical knowledge bases for mapping French expressions
to MeSH terms, and the initial evaluation of their contribution to
Doc'CISMeF, the search tool of a MeSH-indexed directory of French-language
medical Internet resources. The observed trend is in favor of the
use of morphological knowledge as a moderate (approximately 5
but effective factor for improving query to term mapping capabilities.
BibTeX:
@article{Zweigenbaum2001,
  author = {P. Zweigenbaum and S. J. Darmoni and N. Grabar},
  title = {The contribution of morphological knowledge to French MeSH mapping for information retrieval.},
  journal = {Proc AMIA Symp},
  school = {DIAM--Service d'Informatique Médicale, DSI, Assistance Publique--Hôpitaux de Paris and Département de Biomathématiques, Université Paris 6, France. pz@biomath.jussieu.fr},
  year = {2001},
  pages = {796--800},
  url = {http://litismail.insa-rouen.fr/MnemosNet/psipubli.nsf/ce6c2c540f564a2dc125680200361b7c/3b9e8673a13b74c8c1256a8b00485551/$FILE/amia2001cismeflex.pdf}
}

BibTeX:
@inproceedings{SJ.2001,
  author = {Darmoni, SJ},
  title = {Intérêt de l'Internet dans un service médical},
  booktitle = {12ème Journée de la Fédération des Cercles d'Etudes des Gynécologues-Obstétriciens des Hopitaux Généraux Français},
  address = {Deauville, France},
  month = {septembre},
  year = {2001}
}

BibTeX:
@inproceedings{SJ.2001a,
  author = {Darmoni, SJ and HAUGH, MC and LUKACS, B and BOISSEL, JP},
  title = {Level of evidence to assess health content quality on the internet.},
  booktitle = {9th International Cochrane Colloquium},
  address = {Lyon, France},
  month = {October},
  year = {2001},
  url = {http://www.biomedcentral.com/abstracts/cochrane/1/pb076/}
}

BibTeX:
@inproceedings{ZWEIGENBAUM2001a,
  author = {ZWEIGENBAUM, P and GRABAR, N and DARMONI, SJ},
  title = {L'apport de connaissances morphologiques pour la projection de requêtes sur une terminologie normalisée.},
  booktitle = {TALN (Traitement automatique des langues naturelles)},
  address = {Tours, France},
  month = {Juillet},
  year = {2001},
  pages = {397-402},
  url = {http://www.tln.li.univ-tours.fr/Tln_Colloques/TALN2001-RECITAL2001/Actes/tome1_PDF/partie3_p323_402/art13_p397_402.pdf}
}

2000


Abstract: OBJECTIVE: The purpose of this study was to evaluate the efficacy
of a decentralized intranet access in each medical department as
opposed to centralized unique MEDLINE access in the medical library.
DESIGN: A two-phase questionnaire to evaluate MEDLINE use was given
to junior and senior physicians at Rouen University Hospital (RUH).
Phase I (August-October 1996) corresponded to a time period when
centralized access was the only means of access available and phase
II (August-October 1997) to a time period following the introduction
of decentralized intranet access. RESULTS: A total of 168 physicians
filled out at least one phase of the questionnaire, among whom 123
(73 filled out both phases. Use of MEDLINE significantly increased
in 1997 (average of 10.2+/-1.1 searches in three months) versus 1996
(average of 4.9+/-0.7 searches in three months, P<0.0001). The aim
of searches changed, becoming significantly more care oriented in
phase II (P<0.0001). The number of searches performed by the physicians
alone increased (P<0.0001) and searches performed by the librarian
decreased (P<0.0001) in phase II. The method of searches also changed,
as searches by author (P< 0.0001), by journal (P = 0.0042), and by
free word (P = 0.0027) increased in phase II. Knowledge of the following
concepts of MEDLINE significantly increased: explosion (P<0.0001),
scope note (P<0.0001), Abridged Index Medicus (AIM) journals (P<0.0001),
Medical Subject Headings (MeSH) qualifier (P<0.0001), and focus (P<0.0001).
CONCLUSION: A decentralized intranet access to MEDLINE increased
the number of searches and knowledge of this bibliographic database.
MEDLINE intranet access modified the purpose and the methods of searching.
BibTeX:
@article{Darmoni2000b,
  author = {S. J. Darmoni and J. Benichou and B. Thirion and M. F. Hellot and J. Fuss},
  title = {A study comparing centralized CD-ROM and decentralized intranet access to MEDLINE.},
  month = {Apr},
  journal = {Bull Med Libr Assoc},
  school = {Computer and Networks Department, Rouen University Hospital, France.},
  year = {2000},
  volume = {88},
  number = {2},
  pages = {152--156},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=35214}
}

Abstract: In 1999, the Internet has become a major source of health information. The objective of CISMeF is to catalogue and index the main French-speaking health resources. In September 1999, the number of indexed resources totaled over 7,100 with a mean of 75 new sites per week. CISMeF uses two standard tools for organizing information: the Medline bibliographic database MeSH thesaurus and the Dublin Core metadata format. Resources included in CISMeF are described by the following: title, author or creator, subject and keywords, description, publisher, date, resource type, format, identifier, and language. To index resources, CISMeF uses five levels of hierarchy: “meta-term”, category, keyword, subheading, and resource type. CISMeF contains a thematic index, including medical specialities and an alphabetic index. CISMeF respects the Net Scoring, criteria to assess the quality of health information on the Internet. The CISMeF project offers a valuable tool for the French-speaking health community: 2,500 computer users visit the Web site each working day.
BibTeX:
@article{Darmoni2000,
  author = {S. J. Darmoni and J. P. Leroy and F. Baudic and M. Douyère and J. Piot and B. Thirion},
  title = {CISMeF: a structured health resource guide.},
  month = {Mar},
  journal = {Methods of information in medicine},
  school = {Computer and Networks Department, Rouen University Hospital, France. stefan.darmoni@chu-rouen.fr},
  year = {2000},
  volume = {39},
  number = {1},
  pages = {30--35},
  url = {https://methods.schattauer.de/contents/archivepremium/issue/708/issue/special/manuscript/57/show.html}
}

BibTeX:
@article{Darmoni2000c,
  author = {S. J. Darmoni and B. Thirion},
  title = {A standard metadata scheme for health resources.},
  journal = {J Am Med Inform Assoc},
  year = {2000},
  volume = {7},
  number = {1},
  pages = {108--109},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=61461}
}

Abstract: OBJECTIVES: Publications in the field of occupational health appear
in various journals, including those of other medical specialties.
This complicates the follow up of literature for specialists in this
field. On the basis of Medline and the impact factor, this diversity
was assessed, and a cost effective method for selecting the most
pertinent journals in the practice of occupational health was proposed.
METHODS: A Medline search identified all the articles published in
1998 with occupational diseases or occupational exposures as the
main topic. These articles were classified based on the journals
in which they appeared. The journals were then compared according
to their subject area, the number of articles that were published
in the fields studied, and their impact factor. RESULTS: The search
retrieved 2247 articles, published in 577 different journals in 1998.
Each journal published between one and 105 articles during this period
(mean 3.89). However, only 1.4% of the journals accounted for more
than 25% of the total articles published. More than half of the
articles were published in journals dealing with general practice
or medical specialties other than occupational health. Only 66%
of retrieved journals had an impact factor, and more than 80% of
the articles were published in journals with an impact factor <2.
CONCLUSION: Simply following up occupational health journals is not
sufficient to meet the requirements of the occupational health professional.
Moreover, the use of the impact factor cannot be considered as a
reliable research tool to assess follow up. Two lists of eight and
38 journals were thus set up. They permit a literature coverage of
27% and 52% respectively in the specific fields studied, and this
seems to be the optimal compromise between time and literature covered.
Lastly, practical procedures are suggested to follow up literature
and obtain abstracts from selected journals on the internet.
BibTeX:
@article{Gehanno2000,
  author = {J. F. Gehanno and B. Thirion},
  title = {How to select publications on occupational health: the usefulness of Medline and the impact factor.},
  month = {Oct},
  journal = {Occup Environ Med},
  school = {Head Office of the Occupational Health Departments of Paris University Hospitals, Paris, France. jean-francois.gehanno@htd.ap-hop-paris.fr},
  year = {2000},
  volume = {57},
  number = {10},
  pages = {706--709}
}

Abstract: Plus de 7 000 sites médicaux proposent aujourd'hui sur Internet des
contenus destinés aux professionnels de santé. Comment faire le tri?
A quel site se fier? Cet ouvrage a pour objectif d'aider les professionnels
de santé à trouver très rapidement par maladies, symptômes et syndromes,
les sites de référence offrant une information fiable, pertinente
et utile, dans deux domaines prioritaires: la médecine factuelle
que les Anglo-saxons appellent "evidence-based medicine" ou médecine
par les preuves, et qui intègre les recommandations pour la bonne
pratique clinique et les conférences de consensus; l'enseignement:
cours magistraux, matériel d'enseignement, bases de données. Plus
de 1 200 sites francophones, gérés par des universités, des hôpitaux,
des institutions... sont recensés dans ce guide selon les critères
du "Net scoring" de Centrale Santé.
BibTeX:
@book{H.1999,
  author = {CASSAGNE, H and Darmoni, SJ and THIRION, B},
  title = {Internet médical professionnel. Guide des sites de bonne pratique clinique},
  month = {November},
  publisher = {MMI},
  year = {2000},
  pages = {453},
  url = {http://www.worldcat.org/oclc/43554531}
}

Abstract: Internet est devenu une source majeure d'informations santé pour le
grand public. Malheureusement les moteurs de recherche ne permettent
pas d'obtenir l'information disponible de manière claire et organisée.
D'où une perte de temps souvent considérable, et un sentiment de
noyade devant l'avalanche d'informations proposées. En outre la qualié
des informations sur Internet va du meilleur au pire. Le plus souvent
l'origine des informations et le nom des auteurs ne sont pas connus
laissant la porte ouverte à toutes les manipulations scientifiques
et commerciales. Pour vous aider dans cette jungle, le Dr Stéfan
Darmoni, médecin et responsable des nouvelles technologies à la direction
informatique et des réseaux du CHU de Rouen, a sélectionné dans cet
ouvrage les meilleurs sites d'information santé francophones, vraiment
utiles, et surtout fiables, destinés aux patients. Pour chacun des
sites l'auteur précise : - qui produit l'information ; - quels en
sont les auteurs ; - et quel est le contenu. Cet ouvrage sera le
guide de tous ceux qui veulent s'informer en toute confiance sur
Internet dans le domaine de la santé.
BibTeX:
@book{SJ2000,
  author = {Darmoni, SJ},
  title = {Le guide Internet de la santé. Une sélection des meilleurs sites gratuits d'information santé},
  month = {April},
  publisher = {MMI},
  year = {2000},
  pages = {240},
  url = {http://www.worldcat.org/oclc/44602417}
}

BibTeX:
@article{Darmoni2000d,
  author = {Darmoni, SJ and Thirion B and Douyère M and Challoub, C and Leroy, JP},
  title = {Mesure de l'impact des sites Web : le Web Impact Factor. L'exemple des CHU français},
  journal = {Revue du Praticien - Médecine Générale},
  year = {2000},
  volume = {14},
  number = {516},
  pages = {2079-2080}
}

BibTeX:
@article{Darmoni2000a,
  author = {S. J. Darmoni and B. Thirion and J. P. Leroy and F. Baudic and M. Douyere and J. Piot},
  title = {Informations de sante destinees aux patients sur internet},
  month = {October},
  journal = {ITBM-RBM},
  year = {2000},
  volume = {21},
  pages = {281-285},
  url = {http://www.sciencedirect.com/science/article/B7GHY-4C81B96-5/2/ecb5a856a0c0036fae94586747157b96},
  doi = {10.1016/S1297-9562(00)90056-1}
}

BibTeX:
@article{Leroy2000,
  author = {Leroy, JP and Darmoni, SJ and Thirion, B and baudic, F and Douyère, M and Piot, J},
  title = {rechercher les sites médicaux sur l'Internet},
  journal = {L'hôpital Belge},
  year = {2000},
  number = {240},
  pages = {51-58}
}

BibTeX:
@article{Philippe2000,
  author = {Massari, Philippe and Fuss, Jacques},
  title = {Dossier patient informatisé du CHU de Rouen},
  month = {Avril},
  journal = {Gestions hospitalières},
  year = {2000},
  number = {395},
  pages = {316-320},
  url = {http://www.gestions-hospitalieres.fr/article.php?ref_article=1428}
}

BibTeX:
@inbook{Thirion2000a,
  author = {Thirion, Benoit and Benoist, Dominique},
  title = {Intégrer les ressources d'Internet dans la collection},
  publisher = {Les presses de l'ENSSIB},
  year = {2000},
  series = {La Boîte à outils},
  volume = {11}
}

BibTeX:
@article{Thirion2000,
  author = {Thirion, B and Lacoste, B and Videau, S and Douyère, M and Leroy, JP and Goupy, E and Piot, J and Abdulrab, H and Darmoni, SJ},
  title = {Doc'CISMEF un outil de recherche utilisant le thésaurus MeSH},
  journal = {Revue du Praticien - Médecine Générale},
  year = {2000},
  volume = {14},
  number = {506},
  pages = {1427-8}
}

Abstract: This paper is the description of a French Virtual Medical University
based on the federation of existing or currently being developed
resources in several Medical Schools in France. The objectives of
the project is not only to share experiences across the country but
also to integrate several resources using the New Information and
Communication Technologies to support new pedagogical approaches
for medical students and also for continuing medical education. The
project includes: A virtual Medical Campus using secure access from
several sites, The Integration of new interactive resources based
on pedagogical methods, Implementation of new indexing and search
engines based on medical vocabularies and ontologies, The definition
of general and specific portals, the evaluation of the system for
ergonomics and contents.
BibTeX:
@article{Beux2000,
  author = {P. Beux and F. Duff and A. Fresnel and Y. Berland and R. Beuscart and A. Burgun and J. M. Brunetaud and G. Chatellier and S. Darmoni and R. Duvauferrier and M. Fieschi and P. Gillois and F. Guillé and F. Kohler and D. Pagonis and B. Pouliquen and G. Soula and J. Weber},
  title = {The French Virtual Medical University.},
  journal = {Stud Health Technol Inform},
  school = {Medical School of Rennes, France.},
  year = {2000},
  volume = {77},
  pages = {554--562}
}

BibTeX:
@inproceedings{Darmoni2000g,
  author = {Darmoni, SJ and Faure, G and Benichou, J and Roussel, F and Thirion, B and Pinhas, N},
  title = {Reading factor as a credible alternative to impact factor: a preliminary study.},
  booktitle = {Abstracts of MEDNET 2000. The 5th World Congress on the Internet in Medicine. Brussels, 23-26 November 2000.},
  address = {Bruxelles, Belgique},
  journal = {Technology and health care : official journal of the European Society for Engineering and Medicine},
  year = {2000},
  volume = {8},
  pages = {174-175}
}

BibTeX:
@inproceedings{Darmoni2000e,
  author = {Darmoni, SJ and Leroy, JP and Douyère M and Thirion, B},
  title = {Maître-toile : un nouveau métier pour les médecins informaticiens et les bibliothécaires. L'expérience du CHU de Rouen},
  booktitle = {JFIM (Journées Francophones d'Informatique Médicale)},
  address = {Marseille, France},
  year = {2000},
  url = {http://www.chu-rouen.fr/dsii/publi/maitretoile.html}
}

BibTeX:
@inproceedings{J.2000,
  author = {SJ. DARMONI and B. THIRION and JP. LEROY and M. DOUYERE and F. BAUDIC and J. PIOT.},
  title = {CISMeF: a structured Health resource guide for healthcare professionals and patients.},
  booktitle = {RIAO (Recherche d'Informations Assistée par Ordinateur)},
  address = {Paris, France},
  month = {Avril},
  year = {2000},
  url = {http://www3.riao.org/RIAO-2000/RIAO-2000-Program.html}
}

BibTeX:
@inproceedings{Darmoni2000f,
  author = {Darmoni, SJ and Thirion, B and Leroy, JP and Douyère, M and Piot, J},
  title = {The Use of Dublin Core Metadata in a Structured Health Resource Guide on the Internet.},
  booktitle = {Abstracts of MEDNET 2000. The 5th World Congress on the Internet in Medicine. Brussels, 23-26 November 2000.},
  address = {Bruxelles, Belgique},
  journal = {Technology and health care : official journal of the European Society for Engineering and Medicine},
  year = {2000},
  volume = {8},
  pages = {169-170}
}

BibTeX:
@inproceedings{Douyere2000,
  author = {M. Douyère and K. Böer and I. Sanchez and S. J. Darmoni},
  title = {Evaluation of the patient Internet cafe at Rouen University hospital},
  address = {Amsterdam, The Netherlands},
  journal = {Technol. Health Care},
  publisher = {IOS Press},
  year = {2000},
  volume = {8},
  number = {3-4},
  pages = {171--172}
}

BibTeX:
@inproceedings{Gehanno2000a,
  author = {Gehanno, JF and Thirion, B.},
  title = {Comparison of medline and the impact factor for the follow-up of occupational health literature.},
  booktitle = {International Congress on Occupational Health, ICOH'2000},
  address = {Singapore},
  month = {August},
  year = {2000}
}

BibTeX:
@inproceedings{A2000,
  author = {Le Beux, P and Duff, F and Fresnel, A and Beuscart, R and Burgun, A and Brunetaud, JM and Chatellier, G and Cinquin, P and Darmoni, SJ and Fieschi, M and Gillois , P and Kohler, F and Pagonis, D and Soula, G},
  title = {L'université médicale virtuelle française.},
  booktitle = {L'informatique au service du patient comptes rendus des huitièmes Journées francophones d'informatique médicale},
  address = {Marseille, France},
  month = {mai},
  publisher = {Springer-Verlag France},
  year = {2000},
  series = {Informatique et santé},
  pages = {173-184},
  url = {http://www.worldcat.org/oclc/44913558}
}

BibTeX:
@inproceedings{F.2000,
  author = {Le Duff, F and Fresnel, A and Herengt, G and Brunetaud, JM and Chatellier, G and Darmoni, SJ and Gillois, P and Pagonis, D and Soula, G and Spector, M and Le Beux, P},
  title = {Creating resources for e-learning in French medical universities.},
  booktitle = {Abstracts of MEDNET 2000. The 5th World Congress on the Internet in Medicine. Brussels, 23-26 November 2000.},
  address = {Bruxelles, Belgique},
  journal = {Technology and health care : official journal of the European Society for Engineering and Medicine},
  year = {2000},
  volume = {8},
  pages = {178-179}
}

BibTeX:
@inproceedings{2000,,
  title = {CISMeF, Catalogue et Index des Sites Médicaux Francophones},
  booktitle = {Internet : les passerelles du développement, Atelier Télésanté},
  address = {Bamako, Mali},
  month = {Février},
  year = {2000}
}

BibTeX:
@inproceedings{SJ.2000,
  author = {Darmoni, SJ, V. LEROUX, M. DAIGNE, B. THIRION, P. SANTAMARIA, C. DUVAUX, M. GEA.},
  title = {Net Scoring : critères de qualité de l'information de santé sur l'Internet.},
  booktitle = {IPM (Internet et Pédagogie Médicale)},
  address = {Paris, France},
  month = {Mars},
  year = {2000}
}

BibTeX:
@inproceedings{B.2000,
  author = {B. THIRION and B. LACOSTE and S. VIDEAU and M. DOUYERE and JP. LEROY and E. GOUPY and J. PIOT and H. ABDULRAB and SJ Darmoni},
  title = {Doc'CISMeF : un "Medline" francophone pour les ressources Internet.},
  booktitle = {Société Européenne de Télémédecine},
  address = {Paris, France},
  month = {Septembre},
  year = {2000}
}

BibTeX:
@article{Mortiz2000,
  author = {Mortiz, F and de La Chapelle, A and Bauer, F and Leroy, J P and Goullé, J P and Bonmarchand, G},
  title = {Esmolol in the treatment of severe arrhythmia after acute trichloroethylene poisoning.},
  month = {February},
  journal = {Intensive care medicine},
  year = {2000},
  volume = {26},
  pages = {256}
}

1999


Abstract: In 1999, the Internet has become a major source of health information.
The objective of CISMeF is to catalogue and index the main French-speaking
sites and documents concerning health. Currently, the number of resources
already totalled over 6,100 with a mean of 75 new sites each week.
CISMeF contains a thematic index, including medical specialities
and an alphabetic index. CISMeF uses two standard tools for organising
information: the MeSH (Medical Subject Heading) thesaurus from the
Medline bibliographic database (National Library of Medicine) and
the Dublin Core metadata format. A brief description of the site
is systematically added. CISMeF respects the Net Scoring, criteria
to assess the quality of health information on the Internet. The
CISMeF project fulfils a valuable tool for the French-speaking health
community: 2,500 machines visit the Web site each working day.
BibTeX:
@article{Darmoni1999,
  author = {S. J. Darmoni and J. P. Leroy and F. Baudic and M. Douyère and J. Piot and B. Thirion},
  title = {CISMeF: cataloque and index of French speaking health resources.},
  journal = {Stud Health Technol Inform},
  school = {Computer and Networks Department, Rouen University Hospital.},
  year = {1999},
  volume = {68},
  pages = {493--496}
}

Abstract: En 1999, l?Internet est devenu une source majeure d?informations de
santé. Cette note a pour objectif de présenter le catalogue et index
des sites et documents médicaux francophones (CISMeF) accessibles
sur l?internet. CISMeF est un projet lancé par le CHU de Rouen, qui
a vu le jour dès l?existence du site Web du CHU en février 1995 et
qui a pour adresse URL . Ce recensement
indexe les principales ressources francophones. Il comptait plus
de 6 500 sites en mai 1999, avec une moyenne de 75 nouveaux par semaine.
Cette liste de sites est classée par thèmes, en particulier par spécialités
médicales, et par ordre alphabétique. CISMeF utilise 2 outils standard
pour organiser l?information : le thésaurus MeSH (médical subject
headings) de la base de donnée bibliographique Medline et le format
de méta-données du Dublin Core. Chaque site indexé comprend une notice
descriptive. CISMeF respecte le référentiel des critères de qualité
de l?information de santé sur l?Internet (Net Scoring), élaboré en
collaboration avec Centrale santé et APUI-Santé.
BibTeX:
@article{Darmoni1999a,
  author = {S. J. Darmoni and J. P. Leroy and F. Baudic and M. Douyère and J. Piot and B. Thirion},
  title = {CISMeF: catalogue et index des sites médicaux francophones.},
  journal = {Sante},
  school = {CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.},
  year = {1999},
  volume = {9},
  number = {2},
  pages = {123--128},
  url = {http://www.john-libbey-eurotext.fr/fr/revues/sante_pub/san/e-docs/00/04/2D/85/resume.md}
}

Abstract: We report the case of a pediatrician who developed meningococcal meningitis
after performing endotracheal intubation without protection on a
child who was suspected of having meningoencephalitis. This case
emphasizes the necessity for healthcare workers who perform high-risk
procedures to use personal protection devices (i.e., respirators
and protective goggles). Unprotected healthcare workers with high
exposure to Neisseria meningitidis should receive chemoprophylaxis.
BibTeX:
@article{Gehanno1999a,
  author = {Gehanno, J. F. and Kohen-Couderc, L. and Lemeland, J. F. and Leroy, J.},
  title = {Nosocomial meningococcemia in a physician.},
  month = {August},
  journal = {Infection control and hospital epidemiology},
  year = {1999},
  volume = {20},
  number = {8},
  pages = {564--565},
  doi = {10.1086/501672}
}

Abstract: OBJECTIVE: After pertussis was diagnosed in July 1997 in a 55-year-old
nurse (case) from a pediatric emergency unit who had a respiratory
illness and paroxysmal cough for 5 weeks, an epidemiological investigation
was initiated to determine if other healthcare workers (HCWs) from
the same unit also had pertussis. DESIGN: Interviews were conducted
to assess symptoms occurring in the previous months. Two sera were
collected 2 to 3 months apart for 59 of 61 HCWs of the unit. The
IgG response to pertussis toxin was determined using Western blot
assay. SETTING: Pediatric emergency unit (61 HCWs) of a 2,500-bed
university hospital. RESULTS: There was a total of 10 (5 confirmed
and 5 probable) cases of pertussis identified in this outbreak. Nine
HCWs (15 had results suggesting recent or acute pertussis. To
avoid transmission to patients and other HCWs, all HCWs with cough
were treated for 14 days with erythromycin, and those having acute
cough were given a 5-day sick leave. Despite these measures, a new
acute pertussis case was identified in a 41-year-old nurse, with
a positive culture from nasopharyngeal aspirates. Thus, all HCWs
in the unit were prescribed spiramycin for 10 days to prevent any
further spread of pertussis. CONCLUSION: Pertussis should be considered
a threat to HCWs who are in contact with children. For HCWs, diagnosis
of pertussis should be made on a clinical basis, giving greater importance
to sensitivity of diagnosis criteria, and on early bacterial identification
by culture of the organism or by polymerase chain reaction. RECOMMENDATIONS:
In case of pertussis in an HCW, all staff in the unit who have had
unprotected and intensive contact with that person should be provided
with macrolide treatment to stop any transmission to colleagues and
to young patients. Furthermore, the possibility of providing these
HCWs with acellular pertussis vaccines warrants further investigation.
BibTeX:
@article{Gehanno1999,
  author = {Gehanno, J. F. and Pestel-Caron, M. and Nouvellon, M. and Caillard, J. F.},
  title = {Nosocomial pertussis in healthcare workers from a pediatric emergency unit in {France}.},
  month = {August},
  journal = {Infection control and hospital epidemiology},
  year = {1999},
  volume = {20},
  number = {8},
  pages = {549--552},
  doi = {10.1086/501667}
}

Abstract: During a 2-week period, three infants with a cough lasting at least
8 days with whoops, were admitted to the pediatric unit; Bordetella
pertussis was isolated from nasopharyngeal aspirates collected from
the three infants. Approximately 1 week later, a nurse working on
the same unit developed influenza-like symptoms followed by whooping
cough; B pertussis was isolated. Isolates from the nurse and from
one of the infants were shown to be indistinguishable by pulsed-field
gel electrophoresis. These data demonstrate that B pertussis transmission
to healthcare workers is possible and emphasize the need to use respiratory
protection devices (Droplet Precautions) for healthcare workers having
close contact with infected children.
BibTeX:
@article{Nouvellon1999,
  author = {Nouvellon, M. and Gehanno, J. F. and Pestel-Caron, M. and Weber, C. and Lemeland, J. F. and Guiso, N.},
  title = {Usefulness of pulsed-field gel electrophoresis in assessing nosocomial transmission of pertussis.},
  month = {November},
  journal = {Infection control and hospital epidemiology},
  year = {1999},
  volume = {20},
  number = {11},
  pages = {758--760},
  doi = {10.1086/501579}
}

BibTeX:
@article{Thirion1999a,
  author = {Thirion, B and Baudic, F and Douyère, M and Leroy, JP and Piot, J and Darmoni, SJ},
  title = {CISMeF : Catalogue et Index des Sites Medicaux Francophones : pourquoi, comment},
  journal = {Newsletter des Bibliothécaires Européens de la Santé},
  year = {1999},
  number = {47},
  pages = {15-19},
  url = {http://www.eahil.net/newsletter/47/CISMef.htm}
}

BibTeX:
@article{Thirion1999,
  author = {B. Thirion and S. J. Darmoni},
  title = {Simplified access to MeSH tree structures on CISMeF.},
  month = {Oct},
  journal = {Bull Med Libr Assoc},
  school = {Rouen University Hospital, France. Benoit.Thirion@chu-rouen.fr},
  year = {1999},
  volume = {87},
  number = {4},
  pages = {480--481},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=226625}
}

BibTeX:
@article{SJ.1999f,
  author = {Darmoni, SJ and LEROUX, V and DAIGNE, M and THIRION, B and SANTAMARIA, P and DUVAUX, C and GEA, M},
  title = {Net Scoring : critères de qualité de l'information de santé sur l'Internet},
  journal = {Technologie Santé},
  year = {1999},
  volume = {36},
  pages = {128-142}
}

BibTeX:
@article{SJ.1999,
  author = {Darmoni, SJ and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and THIRION, B},
  title = {CISMeF : un site-catalogue de la toile médicale francophone (I)},
  journal = {Revue du Praticien : médecine générale},
  year = {1999},
  volume = {13},
  number = {444},
  pages = {37-38}
}

BibTeX:
@article{SJ.1999a,
  author = {Darmoni, SJ and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and THIRION, B},
  title = {CISMeF : un site-catalogue de la toile médicale francophone (III)},
  journal = {Revue du Praticien : médecine générale},
  year = {1999},
  volume = {13},
  number = {446},
  pages = {131-132}
}

BibTeX:
@article{SJ.1999g,
  author = {Darmoni, SJ and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and THIRION, B},
  title = {CISMeF : un site-catalogue de la toile médicale francophone (II)},
  journal = {Revue du Praticien : médecine générale},
  year = {1999},
  volume = {13},
  number = {445},
  pages = {81-82}
}

BibTeX:
@article{SJ.1999e,
  author = {Darmoni, SJ and ROUSSEL, F and BENICHOU, J and THIRION, B and PINHAS, N},
  title = {La mesure de la lecture pour la gestion des fonds documentaires. De l'avantage des technologies Internet !},
  journal = {Revue du Praticien : médecine générale},
  year = {1999},
  volume = {13},
  number = {469},
  pages = {1363-1364}
}

BibTeX:
@article{SJ.1999b,
  author = {Darmoni, SJ and THIRION, B and LEROY, JP},
  title = {Ressources Internet pour les patients (I)},
  journal = {Revue du Praticien : médecine générale},
  year = {1999},
  volume = {13},
  number = {465},
  pages = {1171-1172}
}

BibTeX:
@article{SJ.1999h,
  author = {Darmoni, SJ and THIRION, B and LEROY, JP},
  title = {Ressources Internet pour les patients (II)},
  journal = {Revue du Praticien : médecine générale},
  year = {1999},
  volume = {13},
  number = {466},
  pages = {1215-6}
}

BibTeX:
@article{SJ.1999c,
  author = {Darmoni, SJ and THIRION, B and LEROY, JP and DOUYERE, M and BAUDIC, F and PIOT, J},
  title = {CISMeF : Catalogue et Index des Sites Médicaux Francophones},
  journal = {Revue du Praticien : médecine générale},
  year = {1999},
  volume = {13},
  number = {482},
  pages = {2165-2173}
}

BibTeX:
@book{Thirion1999b,
  author = {Benoit Thirion and Stéfan Darmoni},
  title = {Sites Internet francophones pour l'enseignement de la médecine},
  address = {Paris},
  publisher = {ADBS},
  year = {1999},
  url = {http://www.worldcat.org/oclc/43360161}
}

BibTeX:
@inproceedings{Darmoni1999c,
  author = {Darmoni, SJ},
  title = {Contrôle-Qualité et Validation des sites médicaux de formation},
  booktitle = {JUFPM (Journées Universitaires Francophones de Pédagogie Médicale)},
  address = {Nantes, France},
  month = {avril},
  year = {1999}
}

BibTeX:
@inproceedings{Darmoni1999b,
  author = {Darmoni, SJ and Leroux, V and Thirion, B and Santamaria, P and Gea, M},
  title = {Net scoring : critères de qualité de l'information de santé sur l'internet},
  booktitle = {JUFPM (Journées Universitaires Francophones de Pédagogie Médicale)},
  address = {Nantes, France},
  month = {avril},
  year = {1999},
  url = {http://www.cidmef.u-bordeaux2.fr/wnantes/}
}

BibTeX:
@inproceedings{SJ.1999i,
  author = {Darmoni, SJ and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and THIRION, B},
  title = {CISMeF: Catalogue and Index of French-speaking health resources},
  booktitle = {MIE 99, Fifteenth International Congress of the European Federation for Medical Informatics},
  address = {Lubjana, Slovenia},
  month = {August},
  year = {1999},
  pages = {493-496}
}

BibTeX:
@inproceedings{B.THIRION1999,
  author = {THIRION, B and Darmoni, SJ and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J},
  title = {CISMeF : un Catalogue et Index des Sites Médicaux Francophones orienté vers l'enseignement et la formation},
  booktitle = {Colloque "Universités virtuelles, vers un enseignement égalitaire"},
  address = {Université de Moncton, campus d'Edmundston, Canada},
  month = {Août},
  year = {1999}
}

BibTeX:
@inproceedings{SJ.1999k,
  author = {Darmoni, SJ and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and THIRION, B},
  title = {CISMeF : Catalogue et Index des Sites Médicaux Francophones},
  booktitle = {Gestion et diffusion électronique de l'information biologique, médicale et en santé},
  address = {Obernai, France},
  month = {Mai},
  year = {1999}
}

BibTeX:
@inproceedings{SJ.1999l,
  author = {Darmoni, SJ and THIRION, B and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J},
  title = {Informations de santé destinées aux patients sur l'Internet},
  booktitle = {CRISTAL'S, Partage d'information en santé},
  address = {Vannes, France},
  month = {Septembre},
  year = {1999},
  pages = {142-148}
}

BibTeX:
@inproceedings{SJ.1999j,
  author = {Darmoni, SJ and Weber, J},
  title = {Université et bibliothèque virtuelles à Rouen},
  booktitle = {Le multimédi@ à l'Université},
  address = {Université René Descartes, Paris, France},
  month = {Mai},
  year = {1999}
}

BibTeX:
@inproceedings{Darmoni1999d,
  author = {Darmoni, Stéfan Jacques},
  title = {Recherche documentaire sur l'Internet},
  booktitle = {Congrès de la Société de Réanimation de Langue Française},
  address = {Paris, France},
  month = {Avril},
  year = {1999}
}

BibTeX:
@inproceedings{B.THIRION1999b,
  author = {THIRION, B},
  title = {CISMeF (Catalogue et Index des Sites Médicaux Francophones) au CHU de Rouen : enjeux et méthodes},
  booktitle = {Information de santé et réseaux. - Journée d'étude du secteur Santé-Médecine-Pharmacie-Biologieavec la collaboration de l'ADBS Rhône-Alpes/Lyon et de l'Enssib},
  address = {Lyon, France},
  month = {Octobre},
  year = {1999}
}

BibTeX:
@inproceedings{B.THIRION1999a,
  author = {THIRION, B and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and Darmoni, SJ},
  title = {SDI : sélection, description, indexation : vous avez dit automatique ?},
  booktitle = {L'indexation à l'ère de l'Internet, ISKO (International Society of Knowledge Organisation)},
  address = {Lyon, France},
  month = {Octobre},
  year = {1999}
}

BibTeX:
@inproceedings{SJ.1999d,
  author = {Darmoni, SJ and LEROY, JP and BAUDIC, F and DOUYERE, M and PIOT, J and THIRION, B},
  title = {CISMeF : Catalogue et Index des Sites Médicaux Francophones},
  booktitle = {JUFPM (Journées Universitaires Francophones de Pédagogie Médicale)},
  address = {Nantes, France},
  month = {Avril},
  year = {1999},
  url = {http://www.cidmef.u-bordeaux2.fr/wnantes/}
}

1998


Abstract: OBJECTIVE: To determine the efficiency of the major bibliographic
databases by assessing the percentage of references among the total
literature available that can be retrieved from each database. We
also evaluated the best database combinations to carry out an exhaustive
search. METHODS: BIOSIS, EMBASE, MEDLINE,
BibTeX:
@article{Gehanno1998b,
  author = {Gehanno, J. F. and Paris, C. and Thirion, B. and Caillard, J. F.},
  title = {Assessment of bibliographic databases performance in information retrieval for occupational and environmental toxicology.},
  month = {August},
  journal = {Occupational and environmental medicine},
  year = {1998},
  volume = {55},
  number = {8},
  pages = {562--566}
}

BibTeX:
@article{DARMONI1998,
  author = {Darmoni, SJ},
  title = {Les sites-catalogues de santé sur l'Internet},
  journal = {Revue du Praticien : médecine générale},
  year = {1998},
  volume = {12},
  number = {426},
  pages = {43-44}
}

Abstract: The goal of this paper is to provide a set of criteria that can be
consistently used to assess the quality of health information on
the Internet. To ensure objectivity, the criteria were developed
by a multidisciplinary group of experts, including representatives
of professional organizations, MDs, engineers and lawyers. When used,
the criteria should improve the quality of the web sites and benefit
to both developers and end-users.
BibTeX:
@article{SJ.1998,
  author = {SJ Darmoni and V. LEROUX and M. DAIGNE and B. THIRION and P. SANTAMARIA and C. DUVAUX.},
  title = {Critères de qualité de l'information de santé sur l'Internet},
  journal = {Santé et Réseaux Informatiques, Informatique et Santé},
  year = {1998},
  volume = {10},
  pages = {162-174},
  url = {http://www.cybermed.jussieu.fr/Broussais/InforMed/InforSante/Volume10/Vol10-pdf/10-19.pdf}
}

BibTeX:
@article{Gehanno1998,
  author = {Gehanno, JF and Malandin, J and Thirion, B and Paris, C},
  title = {Apport de l'Internet en médecine du travail. Sélection de sites utiles},
  journal = {Archives des Maladies Professionnelles et de Médecine du Travail},
  year = {1998},
  volume = {59},
  number = {8},
  pages = {554-61},
  url = {http://www.masson.fr/masson/portal/bookmark?Global=1&Page=18&MenuIdSelected=106&MenuItemSelected=0&MenuSupportSelected=12&CodeRevue4=ADMP&CodeProduct4=360&Path=REVUE/ADMP/1998/59/8/ARTICLE1110790321.xml&Locations=&Pos=7}
}

BibTeX:
@article{Gehanno1998c,
  author = {Gehanno, JF and Pestel-Caron, M and Marguet, C and Nouvellon, M and Gueit, I},
  title = {Épidémie de coqueluche parmi les membres d'un service d'urgence pédiatrique},
  journal = {Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie},
  year = {1998},
  volume = {5},
  number = {1},
  pages = {92--93},
  doi = {10.1016/S0929-693X(97)83477-X}
}

BibTeX:
@article{JL.1998,
  author = {JL. SANTONI and V. LEROUX and A. GUEY and D. RAGAIN and H. RENTIER and D. MREJEN and Darmoni and SJ and M. DAIGNE and J. LEBIDOIS and A. RODACH and P. DE KERVASDOUE and JF. CONSO and P. SANTAMARIA and P. DOSNE and G. HERBRECHT and HA. HANSSKE.},
  title = {Le passage à l'an 2000 en environnement de santé. Un réel problème de sécurité.},
  month = {Avril},
  journal = {Gestions Hospitalières},
  year = {1998},
  pages = {260-2065}
}

BibTeX:
@article{L.1998,
  author = {L. SANTONI and V. LEROUX and A. GUEY A and M. DAIGNE and A. RODACH and C. ERARD and P. SANTAMARIA and L. GRAIL and P. De KERVASDOUE and D. RAGAIN and J. LEBIDOIS and P. DOSNE and G. HEBBRECHT and HA. HANSSKE and JF. CONSO and D. MREJEN and SJ Darmoni and Y. CHARPAK and DUFFET},
  title = {Le passage à l'an 2000 en environnement de santé},
  journal = {Hospitalisation privée},
  year = {1998},
  pages = {31-32}
}

BibTeX:
@article{THIRION1998,
  author = {THIRION, B and DARMONI, SJ.},
  title = {Les sites médicaux francophones sur Internet : le devoir d'ingérence des bibliothèques},
  journal = {Bulletin des Bibliothèques de France},
  year = {1998},
  number = {3},
  pages = {42-45}
}

BibTeX:
@inproceedings{J.1998,
  author = {DARMONI, SJ and BENICHOU, J and THIRION, B and FUSS, J},
  title = {Medline: centralised CD-ROM vs. decentralised Intranet access},
  booktitle = {Mednet, World Congress of the Internet in Medicine},
  address = {London, UK},
  month = {November},
  year = {1998},
  pages = {39}
}

BibTeX:
@inproceedings{SJ.1998b,
  author = {Darmoni, SJ and LEROUX, V and DAIGNE, M and THIRION, B and SANTAMARIA, P and DUBOIS, O and LEBIDOIS, J and MREJEN, D},
  title = {Net scoring: methodology for quality assessment of Web sites in medicine.},
  booktitle = {ITIS 98: International Conference on the Telemedical Information},
  month = {avril},
  year = {1998}
}

BibTeX:
@inproceedings{SJ.1998a,
  author = {Darmoni, SJ and LEROUX, V and DAIGNE, M and THIRION, B and SANTAMARIA, P and DUVAUX, C},
  title = {Critères de qualité de l'information de santé sur l'Internet.},
  booktitle = {Journées Francophones d'Informatique Médicale},
  address = {Liège, Belgique},
  month = {avril},
  year = {1998}
}

BibTeX:
@inproceedings{JP.1998,
  author = {LEROY, JP and Darmoni, SJ and THIRION, B and DROY, JM and LEROY, JP},
  title = {The Rouen Web site: A tool for bibliography and medical information},
  booktitle = {Computer as an aid in poison centres},
  address = {Lille, France},
  month = {décembre},
  year = {1998},
  url = {http://www.chu-rouen.fr/dsii/publi/rouenwebsite1298.html}
}

BibTeX:
@inproceedings{DARMONI1998a,
  author = {Darmoni, SJ},
  title = {Internet santé},
  booktitle = {Journées de Télématique Hospitalière},
  address = {Paris, France},
  month = {Avril},
  year = {1998}
}

BibTeX:
@inproceedings{DARMONI1998b,
  author = {Darmoni, SJ},
  title = {Quels critères d'évaluation pour les sites Internet Santé ?},
  booktitle = {Entretiens de la Technologie},
  address = {Paris, France},
  month = {Avril},
  year = {1998}
}

BibTeX:
@inproceedings{DARMONI1998c,
  author = {Darmoni, SJ},
  title = {Critères de qualité de l'information de santé sur l'Internet},
  booktitle = {Quatrième Salon SITM Solutions Informatiques, Télécoms, et Multimédia pour la Santé},
  address = {Paris, France},
  month = {mai},
  year = {1998}
}

BibTeX:
@inproceedings{SJ.1998c,
  author = {Darmoni, SJ and FRIEDMANN, C},
  title = {Internet et Intranet},
  booktitle = {Journées de la Fédération Hospitalière de France},
  address = {Paris, France},
  month = {Avril},
  year = {1998}
}

BibTeX:
@inproceedings{SJ.1998d,
  author = {Darmoni, SJ and THIRION, B},
  title = {L'Internet et la Santé},
  booktitle = {Hôpital : cap sur le futur, 69ème congrès de l'UHNO},
  address = {Brest, France},
  month = {Juin},
  year = {1998}
}

BibTeX:
@inproceedings{Thirion1998,
  author = {B. Thirion},
  title = {Un exemple : le Web Santé du CHU de Rouen},
  booktitle = {L'utilisation d'Internet et des "Nouvelles technologies de l'information et de la communication" (NTIC) dans l'enseignement supérieur : un enjeu pour les Ecoles du GEI Paris},
  address = {Paris, France},
  month = {Décembre},
  year = {1998}
}

BibTeX:
@inproceedings{L.1998a,
  author = {THIBERVILLE, L and METAYER, J and Darmoni, SJ and YAECHE, P and NOUVET, G},
  title = {Les lésions précancéreuse des bronches sur Internet : www.chu-rouen.fr/pneumo/pneumo0.htm},
  booktitle = {Congrès de la Société Française de Pneumologie},
  address = {Paris, France},
  month = {Février},
  year = {1998}
}

Abstract: Bee stings can cause severe toxic effects when envenomation is massive. While touring in Casamance (Southern Senegal) a white male was severely stung by a swarm of African bees. The massive envenomation caused rhabdomyolysis, hemolysis and acute renal failure. Pathology examination of kidney and bladder specimens showed vasculitis affecting both arteries and veins. The patient was treated with several hemodialysis sessions and renal function returned to normal three months after the incident. Bees in Africa, known as "killer bees", are particularly aggressive. They have recently been imported from tropical zones in America where a large number of deaths have been reported. Most cases of massive envenomation have shown acute tubular necrosis or renal involvement with myoglobinuria or hemoglobinuria. The renal pathology observed in our case is not usually described.
BibTeX:
@article{Bourgain1998,
  author = {Bourgain, C and Pauti, M D and Fillastre, J P and Godin, M and François, A and Leroy, J P and Droy, J M and Klotz, F},
  title = {Envenimation massive après piqûres d'abeilles africaines},
  month = {June},
  journal = {Presse medicale (Paris, France : 1983)},
  year = {1998},
  volume = {27},
  pages = {1099--1101}
}

1997


BibTeX:
@article{Darmoni1997a,
  author = {Darmoni, SJ and Gobe, JM and Roy, B and Fuss, J},
  title = {Year 2000 at Rouen University Hospital},
  journal = {Health Informatics Journal},
  year = {1997},
  volume = {3},
  number = {3},
  pages = {188-189},
  url = {http://jhi.sagepub.com/cgi/content/refs/3/3/188}
}

BibTeX:
@article{Santoni1997,
  author = {Santoni, JL and Leroux, V and Daigne, M and Grail, L and Darmoni, SJ and De Kervasdoue, , P and Lebidois, J and Rodach, A and J.F. Conso, JF and Ragain, D and Lesteven, P and Leroux, V},
  title = {The Year 2000 Security Problem in Healthcare},
  journal = {Health Informatics Journal},
  year = {1997},
  volume = {3},
  number = {3},
  pages = {232-233},
  url = {http://jhi.sagepub.com/cgi/reprint/3/3/232}
}

BibTeX:
@article{Thirion1997,
  author = {B. Thirion and S. J. Darmoni},
  title = {CliniWeb: Managing clinical information on the World-Wide-Web.},
  journal = {J Am Med Inform Assoc},
  year = {1997},
  volume = {4},
  number = {1},
  pages = {71},
  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=61203}
}

Abstract: L'Internet, le plus grand des réseaux d'ordinateurs du monde, améliore
la communication grâce au courrier électronique et l'accès à l'information
par l'intermédiaire du Web. La valeur ajoutée de l'Internet est fondée
sur le partage de l'information: chaque utilisateur représente potentiellement
la richesse de l'information sur l'Internet. Il donne accès à des
banques de données biomédicales, des livres électroniques, des banques
d'information, des milliers de cas cliniques, des journaux électroniques,
des recommandations pour bonnes pratiques et des conférences de consensus.
Le Centre Hospitalier Universitaire de Rouen est l'un des premiers
hôpitaux français à être connecté à l'Internet via le réseau national
de la recherche RENATER. Cinquante services médicaux et administratifs
bénéficient de cette connexion. Notre serveur Web Internet (http://www.chu-rouen.fr)
propose essentiellement un classement des principaux serveurs dans
le secteur de la santé, en particulier les serveurs français et francophones.
Leur nombre en février 1997 a dépassé les 1000 sites (30 à 40 nouveaux
par semaine). Notre serveur Intranet repose sur le concept de bibliothèque
virtuelle, entraînant amélioration de l'accès à l'information et
gains de productivité: dépêches de l'agence de Presse Médicale, accès
décentralisé à Medline et à quinze journaux électroniques plein-texte.
BibTeX:
@article{DARMONI1997a,
  author = {Darmoni, SJ},
  title = {L'impact de l'Internet en médecine},
  journal = {Les Nouvelles dermatologiques},
  year = {1997},
  volume = {16},
  number = {suppl 3},
  pages = {S12-S15},
  url = {http://cat.inist.fr/?aModele=afficheN&cpsidt=2695872}
}

BibTeX:
@article{DARMONI1997,
  author = {DARMONI, Stéfan Jacques},
  title = {Internet/Intranet : de l'expérience du CHU de Rouen aux systèmes d'information hospitalier et de santé},
  journal = {Informatique et Gestion Médicalisée, Informatique et Santé},
  year = {1997},
  volume = {9},
  pages = {181-186}
}

BibTeX:
@book{Darmoni1997,
  author = {Darmoni SJ, Thirion B},
  title = {Annuaire de l'Internet médical francophone 1997},
  publisher = {Médicales Specialises},
  year = {1997},
  series = {Collection Médistratégies},
  pages = {357},
  url = {http://www.worldcat.org/oclc/37845408}
}

BibTeX:
@inproceedings{SJ.1997,
  author = {Darmoni, SJ and GOBE, JM},
  title = {L'accès sécurisé à l'Internet au Centre Hospitalier Universitaire de Rouen},
  booktitle = {Actes d'Infosec'com, Congrès International sur la Sécurité des Systèmes d'Information et des Télécommunications},
  address = {Paris La Défense},
  month = {Juin},
  year = {1997},
  pages = {175-187}
}

BibTeX:
@inproceedings{SJ.1997a,
  author = {Darmoni, SJ and VALLET, G},
  title = {Internet/Intranet : l'expérience du CHU de Rouen},
  booktitle = {Congrès de la Fédération Internationale des Hôpitaux},
  address = {Melbourne, Australie},
  month = {Novembre},
  year = {1997}
}

BibTeX:
@inproceedings{Gehanno1997,
  author = {Gehanno, JF and Thirion, B and Paris, C},
  title = {Are medical databases exhaustive in the field of occupational health? An answer based on two examples.},
  booktitle = {The Ninth International Conference on Occupational Respiratory Diseases},
  address = {Kyoto, Japan},
  month = {October},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997b,
  author = {Darmoni, SJ},
  title = {L'expérience du Centre Hospitalier Universitaire de Rouen sur l'Internet},
  booktitle = {Collège de gynécologie de Bordeaux et du Sud-Ouest},
  address = {Bordeaux, France},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997c,
  author = {Darmoni, SJ},
  title = {Le réseau Internet},
  booktitle = {Société Européenne de Télémédecine},
  address = {Paris, France},
  month = {Janvier},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997d,
  author = {Darmoni, SJ},
  title = {Internet : l'expérience du CHU de Rouen},
  booktitle = {Colloque Une médecine fondée sur les preuves : nouveaux enjeux pour l'industrie pharmaceutique},
  address = {Paris},
  month = {Mars},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997e,
  author = {Darmoni, SJ},
  title = {Internet/Intranet : de l'expérience du CHU de Rouen aux systèmes d'information hospitalier et de santé},
  booktitle = {Journées EMOIS, Evaluation, Management, Organisation en Santé},
  address = {Nancy, France},
  month = {Avril},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997f,
  author = {Darmoni, SJ},
  title = {L'impact de l'Internet en médecine},
  booktitle = {Quatrième Colloque Henri Feulard},
  address = {Paris, France},
  month = {Avril},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997g,
  author = {Darmoni, SJ},
  title = {Internet/Intranet : l'expérience du CHU de Rouen},
  booktitle = {Troisième Salon SITM Solutions Informatiques, Télécoms, et Multimédia pour la Santé},
  address = {Paris, France},
  month = {Mai},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997h,
  author = {Darmoni, SJ},
  title = {Les bases de données},
  booktitle = {SCICOM, Communication scientifique dans les scienes de la vie},
  month = {Septembre},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997i,
  author = {Darmoni, SJ},
  title = {Internet médical},
  booktitle = {Congrès de la Société Française d'ORL et de Pathologie Cervico-Faciale},
  address = {Paris, France},
  month = {Octobre},
  year = {1997}
}

BibTeX:
@inproceedings{DARMONI1997j,
  author = {Darmoni, SJ},
  title = {Internet : mode d'accès et guide pratique},
  booktitle = {JFR, Journées Françaises de Radiologie},
  address = {Paris, France},
  month = {Novembre},
  year = {1997}
}

BibTeX:
@inproceedings{SJ.1997b,
  author = {Darmoni, SJ and VALLET, G},
  title = {Devenir acteur de l'Internet et réussir sont entrée sur les réseaux. Quelle solution pour quel investissement ?},
  booktitle = {Premier Forum Internet Santé : l'hôpital sur Internet, quel avenir pour les réseaux de soins},
  address = {Paris},
  month = {Janvier},
  year = {1997}
}

BibTeX:
@inproceedings{P.1997a,
  author = {P. MASSARI and P. CHAMOUNI and D. BASTIT and L. LECERF and E. GEORGES and P. CZERNICHOW},
  title = {Formation et Information du personnel soignant en Médecine Transfusionnelle : description de la méthode mise en oeuvre au CHU de ROUEN},
  booktitle = {IIème Congrès National de Sécurité Transfusionnelle et d'Hémovigilance. Ier Séminaire européen des systèmes d'Hémovigilance},
  address = {Bordeaux, France},
  month = {Novembre},
  year = {1997}
}

BibTeX:
@inproceedings{P.1997,
  author = {P. MASSARI and P.CHAMOUNI and D. BASTIT and L. FROMENT and H. DAUBERT and P. CZERNICHOW},
  title = {Le dossier transfusionnel corps étranger ou partie intégrante du dossier patient informatisé ? Description de son intégration au dossier informatisé du CHU de ROUEN, évaluation de la traçabilité},
  booktitle = {IIème Congrès National de Sécurité Transfusionnelle et d'Hémovigilance. Ier Séminaire européen des systèmes d'Hémovigilance},
  address = {Bordeaux, France},
  month = {Novembre},
  year = {1997}
}

BibTeX:
@inproceedings{SJ.1997c,
  author = {Darmoni, SJ and THIRION, B},
  title = {Internet and Intranet Web sites at Rouen University Hospital},
  booktitle = {Mednet 97, World Congress of the Internet in Medicine},
  address = {Brighton, UK},
  month = {November},
  publisher = {Arvanatis \& D. Watson},
  year = {1997},
  pages = {23},
  url = {http://www.chu-rouen.fr/dsii/html/interdefeng.html}
}

BibTeX:
@inproceedings{Gehanno1997a,
  author = {Gehanno, JF and Thirion, B and Paris, C},
  title = {Efficiency of some databases in occupational health : example of the allergy to latex},
  booktitle = {3rd International Conference of Occupational Health for Health Care Workers},
  address = {Edinburgh, UK},
  month = {June-July},
  year = {1997}
}

BibTeX:
@inproceedings{R.1997,
  author = {R. VIGNES and SJ Darmoni and J. LEBBE and T. POYNARD},
  title = {VIRAID: Web computer-aided serological diagnosis of acute viral hepatitis. Automatic Creation of a clinical algorithm},
  booktitle = {Mednet 97, World Congress of the Internet in Medicine},
  address = {Brighton, UK},
  month = {November},
  year = {1997},
  pages = {42},
  url = {http://www.chu-rouen.fr/dsii/publi/viraidmednet97.html}
}

BibTeX:
@article{Berthelot-Moritz1997,
  author = {Berthelot-Moritz, F and Chadda, K and Chanavaz, I and Leroy, J P and Droy, J M and Bonmarchand, G and Leroy, J},
  title = {Fatal sodium valproate poisoning.},
  month = {May},
  journal = {Intensive care medicine},
  year = {1997},
  volume = {23},
  pages = {599}
}

1996


BibTeX:
@book{Cassagne1996,
  author = {Hervé Cassagne and Stéfan Darmoni (Préface)},
  title = {Internet pour les médecins découverte, utilisations, sites médicaux},
  address = {Paris},
  publisher = {Editions Médicales Spécialisées},
  year = {1996},
  url = {http://www.worldcat.org/oclc/36358526}
}

Abstract: Le Centre hospitalier universitaire de Rouen s'est connecté à l'Internet
fin 1994. Afin de faciliter l'accès des utilisateurs aux ressources
médicales disponibles sur ce réseau, un serveur Web a été créé dès
février 1995. Il décrit d'une part les ressources locales de l'établissement
(catalogue de la bibliothèque, présentation des services connectés,
publications, etc.), et propose d'autre part des liens vers les principaux
serveurs en médecine, notamment en France. Sont particulièrement
développés les liens vers les ressources documentaires (bibliothèques,
éditeurs, journaux électroniques, répertoires de listes de diffusion,
etc.) et l'informatique médicale (dont les pages sont indexées avec
les termes MESH de Medline).
BibTeX:
@article{Benoit1996,
  author = {Benoît Thirion and Stéfan Darmoni},
  title = {L'Internet, les bibliothèques et la médecine : l'expérience du CHU de Rouen},
  journal = {Documentaliste - Sciences de l'information},
  year = {1996},
  volume = {33},
  number = {3},
  pages = {171-175},
  url = {http://www.adbs.fr/site/publications/documentaliste/536_1.php}
}

BibTeX:
@inproceedings{SJ.1996,
  author = {Darmoni, SJ and THIRION, B},
  title = {Indexing the Web ? A comparative study of three medical Web servers on the Internet: Cliniweb , "Diseases, Disorders and Related Topics", Omni},
  booktitle = {Mednet 96, European Congress of the Internet in Medicine},
  address = {Brighton, UK},
  month = {October},
  year = {1996},
  pages = {5-6},
  url = {http://www.chu-rouen.fr/dsii/html/mdntdl4.html}
}

BibTeX:
@inproceedings{G.1996,
  author = {G. de MOOR and F. de MEYER and G. THIENPONT and SJ Darmoni},
  title = {Hands on the Internet. WWW and demonstration of existing sites related to Medical Informatics and Telematics},
  booktitle = {MIE 96, Thirteenth International Congress of the European Federation for Medical Informatics},
  address = {Copenhague, Danemark},
  month = {August},
  year = {1996}
}

BibTeX:
@inproceedings{DARMONI1996,
  author = {Darmoni, SJ},
  title = {L'avenir de l'Internet dans le milieu de la santé},
  booktitle = {Vèmes Journées de Télématique Hospitalière},
  address = {Lacanau, France},
  month = {Mai},
  year = {1996}
}

BibTeX:
@inproceedings{DARMONI1996a,
  author = {Darmoni, SJ},
  title = {L'Internet au CHU de Rouen},
  booktitle = {Deuxième Salon SITM Solutions Informatiques, Télécoms, et Multimédia pour la Santé},
  address = {Paris, France},
  month = {Mai},
  year = {1996}
}

1995


Abstract: Nurse scheduling is a difficult and time consuming task. The schedule
has to determine the day to day shift assignments of each nurse for
a specified period of time in a way that satisfies the given requirements
as much as possible, taking into account the wishes of nurses as
closely as possible. This paper presents a constraint-based, artificial
intelligence approach by describing a prototype implementation developed
with the Charme language and the first results of its use in the
Rouen University Hospital. Horoplan implements a non-cyclical constraint-based
scheduling, using some heuristics. Four levels of constraints were
defined to give a maximum of flexibility: French level (e.g. number
of worked hours in a year), hospital level (e.g. specific day-off),
department level (e.g. specific shift) and care unit level (e.g.
specific pattern for week-ends). Some constraints must always be
verified and can not be overruled and some constraints can be overruled
at a certain cost. Rescheduling is possible at any time specially
in case of an unscheduled absence.
BibTeX:
@article{Darmoni1995a,
  author = {S. J. Darmoni and A. Fajner and N. Mahé and A. Leforestier and M. Vondracek and O. Stelian and M. Baldenweck},
  title = {HOROPLAN: computer-assisted nurse scheduling using constraint-based programming.},
  journal = {J Soc Health Syst},
  school = {Rouen University Hospital, France.},
  year = {1995},
  volume = {5},
  number = {1},
  pages = {41--54}
}

BibTeX:
@article{Darmoni1995,
  author = {S. J. Darmoni and B. Thirion},
  title = {Understanding MeSH for literature searches.},
  month = {Jan},
  journal = {JAMA},
  year = {1995},
  volume = {273},
  number = {3},
  pages = {184; author reply 184--184; author reply 185}
}

BibTeX:
@inbook{Joly1995,
  author = {Darmoni, SJ and Baldenweck, M and Joly, H (DIR)},
  title = {Biomédecine 2000 faits et réflexions sur les systèmes de santé de l'an 2000},
  address = {Paris},
  publisher = {Technique \& documentation - Lavoisier},
  year = {1995},
  pages = {45-51},
  url = {http://www.worldcat.org/oclc/33255502}
}

BibTeX:
@article{SJ.1995,
  author = {SJ Darmoni and P. MASSARI and J. STREIFF and M. MONCONDUIT and M. BALDENWECK and P. HECKETSWEILER},
  title = {REX: Transmission informatisée des résultats de laboratoires au sein du CHU de Rouen},
  journal = {Technologie Santé},
  year = {1995},
  volume = {23},
  pages = {24-28}
}

BibTeX:
@article{1995,,
  title = {Internet accessible au CHU de Rouen},
  journal = {Gestions Hospitalières},
  year = {1995},
  pages = {349-350}
}

Abstract: The aim of SETH is to give end-users specific advice concerning treatment
and monitoring of drug poisoning. It is developed with an off the
shelf expert system shell and runs on a microcomputer. The SETH expert
system simulates the expert reasoning, taking into account for each
toxicological class delay, signs and dose. The implementation of
Seth began in April 1992 in our Poison Control Centre (PCC). SETH
is then daily used by residents as telephone response support on
drug poisoning. Between April 1992 and October 1994, 2099 cases inputted
by residents were analysed by SETH. In October 1994, a functional
evaluation of SETH showed that its effect in the daily practise of
our PCC is positive: the performance of the residents increased and
they would agree to use it outside our University Hospital. An expert
system in clinical toxicology is a valuable tool in the daily practise
of a Poison Control Centre.
BibTeX:
@inproceedings{Darmoni1995b,
  author = {Stéfan J. Darmoni and Philippe Massari and Jean-Michel Droy and Thierry Blanc and Jacques Leroy},
  title = {Functional Evaluation of SETH: An Expert System In Clinical Toxicology},
  booktitle = {AIME '95: Proceedings of the 5th Conference on Artificial Intelligence in Medicine in Europe},
  address = {London, UK},
  publisher = {Springer-Verlag},
  year = {1995},
  pages = {231--238},
  doi = {10.1007/3-540-60025-6}
}

BibTeX:
@inproceedings{DARMONI1995,
  author = {Darmoni, SJ},
  title = {L'Internet au CHU de Rouen},
  booktitle = {Séminaire Internet, Hôpital Lariboisière},
  address = {Paris, France},
  month = {Mai},
  year = {1995}
}

BibTeX:
@inproceedings{JP.1995,
  author = {THIERRY, JP and Darmoni, SJ},
  title = {Télémédecine et Médecine On-Line},
  booktitle = {On-Line 95},
  address = {Paris La Défense, France},
  month = {Juin},
  year = {1995}
}

BibTeX:
@inproceedings{J.1995,
  author = {SJ. DARMONI and P. MASSARI and JM. DROY and T. BLANC and F. MORITZ and N. MAHE and J. LEROY},
  title = {From general reasoning in drug poisoning to specific attitudes in human and in SETH},
  booktitle = {Computer as an aid in poison centres},
  address = {Lille, France},
  month = {Mai},
  year = {1995}
}

BibTeX:
@inproceedings{P.1995,
  author = {MASSARI, P and Darmoni, SJ and DROY, JM and BLANC, T and MORITZ, F and MAHE, N and LEROY, J},
  title = {Seth, an expert system in drug poisoning: five years later},
  booktitle = {Computer as an aid in poison centres},
  address = {Lille, France},
  month = {Décembre},
  year = {1995}
}

1994


Abstract: The aim of SETH is to give end-users specific advice concerning treatment
and monitoring of adult drug poisoning. SETH is developed with an
off the shelf expert system shell (KBMS) and runs on a microcomputer.
Technical choices were done according to this analysis, financial
considerations and portability. Currently, the database contains
1000 French drugs from 75 different toxicological classes. The SETH
expert system simulates the expert reasoning, taking into account
for each toxicological class delay, signs and dose. Two phases of
evaluation were performed. The experimental implementation of Seth
began in April 1992 in our Poison Control Centre. Since then, 1100
cases inputted by residents were analysed by SETH. The extension
of the knowledge base to child poisoning began in March 1993.
BibTeX:
@article{Darmoni1994,
  author = {S. J. Darmoni and P. Massari and J. M. Droy and N. Mahe and T. Blanc and E. Moirot and J. Leroy},
  title = {SETH: an expert system for the management on acute drug poisoning in adults.},
  month = {Jun},
  journal = {Comput Methods Programs Biomed},
  school = {Information System and Informatics Department, Rouen University Hospital, France.},
  year = {1994},
  volume = {43},
  number = {3-4},
  pages = {171--176}
}

BibTeX:
@article{BALDENWECK1994,
  author = {M. BALDENWECK},
  title = {Réseaux de soins, nouvelles technologiesinformatiques et télécommunications},
  journal = {Technologie Santé},
  year = {1994},
  volume = {18},
  pages = {136-139}
}

BibTeX:
@article{SJ.1994,
  author = {Darmoni, SJ and RIOU, C and BEN SAID, M},
  title = {Base de connaisssances},
  journal = {Informatique et Santé},
  year = {1994},
  volume = {19},
  pages = {12-14}
}

BibTeX:
@inproceedings{SJ.1994a,
  author = {Darmoni, SJ and DUFOUR, F and MASSARI, P and ARNOUDTS, S and DIEU, B and ALIZON, B and HANTUTE, F and BALDENWECK, M},
  title = {Consultation of the Electronic Vidal dictionary in the Rouen University Hospital: analysis of the first year of utilisation},
  booktitle = {Proceedings of MIE 94, Twelfth International Congress of the European Federation for Medical Informatics},
  address = {Lisbonne, Portugal},
  month = {May},
  year = {1994},
  pages = {384-388},
  url = {http://www.chu-rouen.fr/dsii/publi/vidmie.html}
}

BibTeX:
@inproceedings{P.1994,
  author = {P. MASSARI and I. SMURAGA and L. FROMENT and S. BOUDEHENT and P. CZERNICHOW and J. STREIFF and M. BALDENWECK and P. HECKETSWEILER},
  title = {Application de gestiondes dossiers patients du C.H.U. de ROUEN (Diamant). Mise en place et évaluationde l'utilisation},
  booktitle = {Cinquièmes Journées Francophones d'Informatique Médicale,Dossier Patient, Codage et Langages Médicaux},
  address = {Genève, Suisse},
  month = {Juin},
  year = {1994}
}

BibTeX:
@inproceedings{SJ.1994b,
  author = {SJ Darmoni and A. FAJNER and N. MAHE and A. LEFORESTIER and O. STELIAN and M. VONDRACEK and M. BALDENWECK},
  title = {Horoplan: computer-assisted nurse scheduling using contraint-based programming},
  booktitle = {Proceedings of MIE 94, Twelfth International Congress of the European Federation for Medical Informatics},
  address = {Lisbonne, Portugal},
  month = {May},
  year = {1994}
}

BibTeX:
@inproceedings{J-M.1994,
  author = {J-M. DEBBASCH and SJ Darmoni and J. LEBBE and R. VIGNES and G. COSCAS.},
  title = {HERETAIN: computer aided identification of inherited retinal diseases},
  booktitle = {Clinical Digest Series},
  year = {1994}
}

1993


Abstract: The diagnosis of hereditary retinal syndromes may be difficult for
a physician because of their number and variability. A computer assisted
diagnosis of these syndromes can be useful in such cases. We used
an identification software (XPER) for this purpose. The data base
contains more than 67,000 elementary data that enable us to define
115 hereditary retinal syndromes. The knowledge is not represented
by description of typical cases or diagnostic procedure rules but
by structured description of syndromes defined by the group of experts.
This CAI software is characterised by specific optimising procedures,
deductive algorithms and dissimilarities calculus and enables very
fast diagnoses by limiting the number of complementary analyses and
thus the cost of this research. This system is extensible and justifies
all its conclusions, its user-friendly data representation makes
it accessible for any physician even if he does not master computers.
The selected pathology field seems very suitable to developing a
computer assisted diagnosis system: many low frequency syndromes,
meaningful precise diagnosis for genetic and professional counseling,
therapeutic expectations due to progress in molecular genetics. According
to the authors, HERETAIN is one of the largest computer assisted
decision support systems in ophthalmology.
BibTeX:
@article{Debbasch1993,
  author = {J. M. Debbasch and S. J. Darmoni and J. Lebbe and R. Vignes and G. Coscas},
  title = {HERETAIN: un système de diagnostic assisté par ordinateur des syndromes héréditaires rétiniens},
  journal = {J Fr Ophtalmol},
  school = {Clinique Ophtalmologique Universitaire, Créteil.},
  year = {1993},
  volume = {16},
  number = {6-7},
  pages = {392--396}
}

BibTeX:
@article{BALDENWECK1993,
  author = {M. BALDENWECK},
  title = {Le devenir de l'informatique des hôpitaux.Un nouvau rôle pour le CNEH. Réalités, réflexions et hypothèses d'évolution},
  journal = {Technologie Santé},
  year = {1993},
  volume = {14},
  pages = {49-55}
}

BibTeX:
@article{SJ.1993a,
  author = {SJ Darmoni and J. LEBBE and R. VIGNES and T. POYNARD},
  title = {Makey: génération automatique d'un algorithme clinique pour aider le diagnostic sérologique de l'hépatite virale aiguë},
  journal = {Informatique et Santé},
  year = {1993},
  volume = {15},
  pages = {49-55}
}

BibTeX:
@article{SJ.1993,
  author = {SJ Darmoni and P. MASSARI and F. DUFOUR and S. ARNOUDTS and B. DIEU and B. ALIZON and F. HANTUTE and M. BALDENWECK},
  title = {Consultation du Vidal Electronique au CHU de Rouen},
  journal = {Technologie Santé},
  year = {1993},
  volume = {14},
  pages = {61-65}
}

BibTeX:
@inproceedings{SJ.1993c,
  author = {SJ Darmoni and P. MASSARI and F. DUFOUR and S. ARNOUDTS and B. DIEU and B. ALIZON and F. HANTUTE and M. BALDENWECK},
  title = {Consultation du Vidal Electronique au CHU de Rouen},
  booktitle = {Télématique et Médecine, Quatrièmes Journées Francophones d'Informatique Médicale},
  address = {Bruxelles, Belgique},
  month = {Juin},
  year = {1993}
}

BibTeX:
@inproceedings{SJ.1993b,
  author = {SJ Darmoni and P. MASSARI and JM. DROY and E. MOIROT and J. LE ROY},
  title = {SETH: an expert system for the management on acute drug poisoning in adults},
  booktitle = {Proceedings of MIE 93, Eleventh International Congress of the European Federation for Medical Informatics},
  address = {Jérusalem, Israël},
  month = {Avril},
  year = {1993}
}

1992


Abstract: The aim of this study was to describe and to evaluate the publications
of the last 30 years devoted to computer-aided decision support in
clinical hepatology. The search used Medlars and references of articles.
Computer-aided decision support (CADS) was classified in two categories:
statistical systems and knowledge-based systems. Two specific questionnaires
were used for methodologic evaluation, one for statistical systems
and one for knowledge-based systems. They were filled out independently
by two observers. A total of 31 papers were selected among 55 identified
between 1960 and 1991. The maximum possible for the two scores was
24. The methodologic quality ranged from 4 to 22 (median, 12) for
statistical systems and from 8 to 12 (median, 9) for knowledge-based
systems. The poor level of methodology could explain in part the
lack of utilization of computer-aided decision support in the daily
clinical practice of hepatologists.
BibTeX:
@article{Darmoni1992,
  author = {S. J. Darmoni and T. Poynard},
  title = {Computer-aided decision support in hepatology.},
  month = {Oct},
  journal = {Scand J Gastroenterol},
  school = {Regional Center for Hospital Informatics of Haute Normandie, Rouen, France.},
  year = {1992},
  volume = {27},
  number = {10},
  pages = {889--896}
}

BibTeX:
@article{Thirion1992,
  author = {B. Thirion and S. J. Darmoni and N. Moore},
  title = {Costs of medline and CD-ROM searching.},
  month = {Aug},
  journal = {Lancet},
  year = {1992},
  volume = {340},
  number = {8814},
  pages = {308}
}

BibTeX:
@article{P.1992a,
  author = {P. Allaire and SJ. Darmoni and P. Massari and JL. Caffarel and M. Monconduit and M. Baldenwck and P. Hecketsweiler.},
  title = {REX: Informatisation du circuit de retour des résultats des examens de laboratoires (REX): deux d'utilisation.},
  journal = {Spectra Biologie},
  year = {1992},
  volume = {5},
  pages = {Suppl: 12-16}
}

BibTeX:
@article{P.1992b,
  author = {P. ALLAIRE and P. MASSARI and M. BALDENWECK and Darmoni, SJ},
  title = {REX: Transmission informatisée des résultats de laboratoires du CHR de Rouen},
  journal = {Informatique et Santé},
  year = {1992},
  volume = {9},
  pages = {38-43}
}

BibTeX:
@inproceedings{SJ.1992b,
  author = {SJ Darmoni and P. MASSARI and P. ALLAIRE and JL. CAFFAREL and M. MONCONDUIT and M. BALDENWECK and P. HECKETSWEILER},
  title = {REX: Transmission informatisée des résultats de laboratoires au sein du CHR de Rouen},
  booktitle = {Actes du Sixième Forum Jeunes Chercheurs en Génie Biologique et Médical Innov. Tech. Biol. Med},
  year = {1992},
  pages = {38-39}
}

BibTeX:
@article{SJ.1992a,
  author = {Darmoni, SJ and POYNARD, T},
  title = {Les systèmes informatiques d'aide à la décision en hépatologie},
  journal = {Gastroentérologie},
  year = {1992},
  volume = {6},
  pages = {15-19}
}

BibTeX:
@inproceedings{P.1992,
  author = {P. Allaire and SJ. Darmoni and P. Massari and M. Monconduit and M. Baldenwck and P. Hecketsweiler.},
  title = {Informatisation du circuit de retour des résultats des examens de laboratoires (REX): deux d'utilisation.},
  booktitle = {Congrès Européen de l'informatique Hospitalière},
  address = {Paris, France},
  month = {Juin},
  year = {1992}
}

BibTeX:
@inproceedings{M.1992,
  author = {M. BALDENWECK and P. MASSARI and J. STREIFF and S. BOUDEHENT and P. CZERNICHOW and P. HECKETSWEILER},
  title = {La Gestion du dossier médical et le PMSI : le projet DIAMANT},
  booktitle = {Congrès Européen de l'Informatique Hospitalière},
  address = {paris, France},
  month = {Juin},
  year = {1992}
}

BibTeX:
@inproceedings{Massari1992,
  author = {Massari, P. and Darmoni, S.J. and Droy, J.M. and Moirot, E. and Leroy, J.},
  title = {Seth: A Toxicological Expert System In Adult Drugs Poisoning},
  booktitle = {Proc. Annual International Conference of the IEEE Vol.14 Engineering in Medicine and Biology Society},
  year = {1992},
  volume = {3},
  pages = {906--907}
}

BibTeX:
@inproceedings{P.1992c,
  author = {P. MASSARI and Darmoni, SJ and JM. DROY and E. MOIROT and J. LEROY},
  title = {Seth: a toxicological expert system, giving advice on treatment and monitoring, in adult poisoning with known drugs},
  booktitle = {European Association of Poison Centres \& Clinical Toxicologists Meeting},
  address = {Istanbul, Turquie},
  month = {Mai},
  year = {1992}
}

BibTeX:
@inproceedings{SJ.1992c,
  author = {Darmoni, SJ and DEBBASCH, JM and LEBBE, J and VIGNES, R},
  title = {Utilisation d'une approche symbolique numérique dans la réalisation d'un système d'aide à la décision en ophtalmologie},
  booktitle = {Troisièmes Journées de Symbolique-Numérique pour l'Apprentissage de Connaissances à partir de données},
  address = {Paris, France},
  month = {Mai},
  year = {1992},
  pages = {333-342}
}

BibTeX:
@inproceedings{JM.1992,
  author = {DROY, JM. and Darmoni, SJ and MASSARI, P. and MOIROT, E. and LEROY, J},
  title = {Seth: aide à la conduite à tenir devant une intoxication médicamenteuse de l'adulte},
  booktitle = {Trentième Congrès de la Société de Toxicologie Clinique et des Centres Anti-Poisons Français},
  address = {Tours, France},
  month = {Novembre},
  year = {1992}
}

BibTeX:
@inproceedings{SJ.1992,
  author = {Darmoni, SJ and Lebbe, J and Vignes, R and Poynard, T},
  title = {Makey: Automatic generation of a clinical algorithm for the serological diagnosis of acute viral hepatitis.},
  booktitle = {MEDINFO 92, 7th World Congress on Medical Informatics},
  address = {Genève, Suisse},
  month = {Septembre},
  year = {1992},
  pages = {584}
}

BibTeX:
@inproceedings{Darmoni1992a,
  author = {Darmoni, SJ. and Massari, P and Allaire, P and Caffarel, JL and Monconduit, M and Baldenweck, M and Hecketsweiler, P},
  title = {REX: Extralaboratory Cycle Of Information Processing From Laboratories To Care Units},
  booktitle = {Proc. Annual International Conference of the IEEE Vol.14 Engineering in Medicine and Biology Society},
  year = {1992},
  volume = {3},
  pages = {1253--1254}
}

BibTeX:
@inproceedings{P.1992d,
  author = {Massari, P and Darmoni, SJ and Droy, JM and Moirot, E and Leroy, JP},
  title = {Drug poisoning expert system (SETH)},
  booktitle = {European Society of Medical Decision Making},
  address = {Marburg, Allemagne},
  month = {Juin},
  year = {1992}
}

1991


Abstract: The aim of this study was to realize a prototype of a computer-aided
decision support for prenatal visits. He has been developped on a
microcomputer. We used procedural programming to represent the medical
knowledge. This prototype has several interfaced units: a computerized
prenatal record, the computing of quantitative variables (term, fetal
biometry, uterine height) and the two computer-aided units (preterm
births and modelization of weight gain during pregnancy). The next
step will be the medical evaluation of this computer-aided decision
support in obstetrics.
BibTeX:
@article{Darmoni1991a,
  author = {Darmoni, SJ and Berardi, JC and Berthet, C and Papiernik, E},
  title = {Système d'aide à la décision en obstétrique. L'informatisation des consultations prénatales.},
  journal = {J Gynecol Obstet Biol Reprod (Paris)},
  school = {CRIH Haute Normandie, Rouen.},
  year = {1991},
  volume = {20},
  number = {7},
  pages = {893--897}
}

Abstract: The goal of this study was to modelize the evolution of "ideal" weight
gain during pregnancy and to generate automatically the appropriate
diet. This computerized model has been developed on a microcomputer
and has two units: the first unit calculates the "ideal" weight gain
during pregnancy, based on the curves of Rosso which show that weight
gain is not linear with term and depends of the prepregnancy weight.
The second unit calculates the appropriate diet which is depending
for the first visit on height, prepregnancy weight and weight gain
and for the followed visits on weight gain and the diet situation
of the previous visit. The next step will be the medical evaluation
of this computer-aided modelization of weight gain during pregnancy.
BibTeX:
@article{Darmoni1991,
  author = {Darmoni, SJ and François, P and Berardi, JC and Berthet, C and Papiernik, E},
  title = {Modélisation assistée par ordinateur de la prise de poids au cours de la grossesse.},
  journal = {Rev Fr Gynecol Obstet},
  school = {Centre Régional d'Informatique Hospitalière de Haute Normandie, Rouen.},
  year = {1991},
  volume = {86},
  number = {7-9},
  pages = {533--537}
}

BibTeX:
@inproceedings{P.1991,
  author = {Massari, P and Darmoni, SJ and Gibert, P and Droy, JM and Moirit, E and Leroy, JP},
  title = {Seth: a toxicological expert system, giving advices on treatment and monitoring, in adult poisoning with known drugs.},
  booktitle = {European Association of Poison Centres \& Clinical Toxicologists Meeting, Computers as an aid in poison centres},
  address = {Lille, France},
  month = {Octobre},
  year = {1991}
}

1990


BibTeX:
@article{Darmoni1990,
  author = {Darmoni, SJ and Richard, A and Parisot, P and François, P and Berardi, JC and Berthet, C and Papiernik, E},
  title = {Influence sur le poids de naissance du nouveau-né de la prise de poids des femmes enceintes.},
  journal = {Presse Med},
  year = {1990},
  volume = {19},
  number = {1},
  pages = {35}
}

Abstract: The goal of this study was to evaluate the computer-aided diagnosis
systems used for functional intestinal disorders published between
1970 and 1989. The methodology of all prospective studies published
was evaluated using a score system of 12 items, filled in by two
independent observers. A total of 10 studies were identified. None
of the systems studied could truly be considered as an expert system.
Most systems were not methodologically sound and the median score
was 11 of a possible total of 24. The two principal characteristics
of functional intestinal disorders are their high prevalence and
the absence of objective diagnostic criteria. Taking these two facts
into consideration when elaborating a diagnostic method, expert systems
should be useful for teaching purposes and for conducting prospective
epidemiologic or therapeutic studies. It seems too early, however,
to consider the use of veritable expert systems as an aid to the
practitioner in daily practice.
BibTeX:
@article{Poynard1990,
  author = {Poynard, T and Lemann, M and Darmoni, SJ},
  title = {Qu'attendre des systèmes experts pour le diagnostic des troubles fonctionnels intestinaux.},
  journal = {Gastroenterol Clin Biol},
  school = {Service d'Hépato-Gastroentérologie, Hôpital Antoine-Béclère, Clamart.},
  year = {1990},
  volume = {14},
  number = {5 ( Pt 2)},
  pages = {45C--48C}
}

BibTeX:
@inproceedings{Darmoni1990a,
  author = {Darmoni, SJ},
  title = {Que peut-on attendre de l'informatique.},
  booktitle = {2ème Journée du CEGORIF (Cercle d'Etude des Gynécologues Obstétriciens de la Région Ile-de- France)},
  address = {Paris, France},
  month = {avril},
  year = {1990}
}

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