Somatostatin Receptor Type 5

Preferred Label : Somatostatin Receptor Type 5;

NCIt synonyms : SSTR5; Somatostatin Receptor-5; Somatostatin Receptor Subtype 5; SS-5-R; Somatostatin Receptor 5; SS5-R; SS5R;

NCIt definition : Somatostatin receptor type 5 (364 aa, 39 kDa) is encoded by the human SSTR5 gene. This protein is involved in somatostatin-dependent G protein-coupled receptor signaling.;

NCIt note : Somatostatin receptor (SSTR) 5 and D2R GPCRs interact to create a novel receptor with enhanced activity; either ligand promotes heterodimerization. SSTR5 increases DNA synthesis, whereas SSTR2 inhibits DNA synthesis and cell proliferation. SSTR2 appears to antagonize SSTR5, and vice versa, suggesting a tissue-specific function and interaction between these receptors. SSTR5 is expressed in adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus.(OMIM 182455 and SWISS-PROT P35346);

Details

Origin ID

C17927;

UMLS CUI

C1568739;

Automatic exact mappings (from CISMeF team)
- Somatostatin receptor 5 [OMIM Phenotype]
- Somatostatin receptor 5 [OMIM gene]
- Somatostatin receptor 5 [ORDO Gene]
- somatostatin receptor 5 [HGNC gene]
Currated CISMeF NLP mapping
- somatostatin receptor 5 [MeSH Supplementary Concept]
False automatic mappings
- somatostatin receptor 5 [MeSH concept]
OMIM relation
- Somatostatin receptor 5 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- SSTR5 protein, human [MeSH concept]
- somatostatin receptor 5 [MeSH concept]
- somatostatin receptor 5 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- SSTR5 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Protein Hormone Receptor [NCIt concept]
- Somatostatin Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Lanreotide Acetate [NCIt concept]
- Lanreotide Long-Acting Aqueous Gel [NCIt concept]
- Long-acting Release Pasireotide [NCIt concept]
- Octreotide [NCIt concept]
- Octreotide Acetate [NCIt concept]
- Octreotide Depot Formulation CAM2029 [NCIt concept]
- Octreotide Pamoate [NCIt concept]
- Octreotide Sustained-release Formulation Debio 4126 [NCIt concept]

Keyword's position in hierarchy(ies) :

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