Preferred Label : Octreotide Depot Formulation CAM2029;
NCIt synonyms : Octreotide Subcutaneous Depot CAM2029; Octreotide SC Depot CAM2029;
NCIt definition : A long-acting depot formulation of the synthetic octapeptide and somatostatin analog
octreotide, with potential growth hormone (GH) secretion-inhibiting and antineoplastic
activities. Upon subcutaneous administration of octreotide depot formulation CAM2029,
octreotide binds to and activates somatostatin receptors (SSTRs), including subtypes
2 and 5, which leads to an inhibition in the secretion of human growth hormone (hGH)
in the pituitary gland and results in decreased production of insulin-like growth
factor (IGF-1). This may inhibit IGF-1-mediated cell signaling pathways, and lead
to apoptosis. Octreotide may also block key survival pathways such as the phosphatidylinositol
3-kinase (PI3K) and the mitogen-activated protein kinase (MAPK) signaling pathways.
In addition, octreotide may inhibit tumor angiogenesis. Altogether, this may result
in tumor cell death and inhibition of tumor cell proliferation and angiogenesis. SSTRs
are overexpressed by some neuroendocrine and non-neuroendocrine tumor cells, and GH
is over-produced in the pituitary gland in acromegaly.;
Molecule name : CAM 2029; CAM-2029;
NCI Metathesaurus CUI : CL1773485;
Origin ID : C185136;
UMLS CUI : C4305847;
- Semantic type(s)
- concept_is_in_subset
- has_target