Cathepsin - CISMeF

Preferred Label : Cathepsin;

NCIt synonyms : Cathepsins;

NCIt definition : Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis.;

Alternative definition : CDISC: Antigen(s) of the lysosomal proteinase or endopeptidase family and are encoded by the CTS gene. They can be considered as autoantigens and are commonly associated with systemic vasculitis, inflammatory rheumatic diseases, autoimmune hepatitis, and chronic inflammatory bowel diseases.;

Details

Origin ID

C16389;

UMLS CUI

C0007428;

Automatic exact mappings (from CISMeF team)
- Carboxypeptidase C (substance) [SNOMED CT concept]
- Cathepsin A [LOINC component]
- Cathepsin a [OMIM gene]
- Lysosomal carboxypeptidase B (substance) [SNOMED CT concept]
- cathepsin A [ORDO Gene]
- cathepsin A [HGNC gene]
- cathepsin A [MeSH Descriptor]
- cathepsin A [MeSH concept]
- cathepsin b [MeSH Descriptor]
- cathepsin b [SNOMED Notion]
- cathepsin d [MeSH Descriptor]
- cathepsin d [SNOMED Notion]
- cathepsin e [MeSH Descriptor]
- cathepsin g [SNOMED Notion]
- cathepsin h [SNOMED Notion]
- cathepsin l [SNOMED Notion]
- cathepsin r [SNOMED Notion]
Currated CISMeF NLP mapping
- cathepsins [MeSH Descriptor]
- cathepsins [MeSH concept]
False automatic mappings
- Cathepsin (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cathepsin (substance) [SNOMED CT concept]
- cathepsins [MeSH concept]
- cathepsins [MeSH Descriptor]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Odanacatib [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
is_target
- Cathepsin-cleavable NIR Substrate Probe 6QC-ICG [NCIt concept]
- Cathepsin-cleavable NIR Substrate Probe 6QC-NIR [NCIt concept]
- Cathepsin-targeted Fluorescent Imaging Probe VGT-309 [NCIt concept]
- Pegulicianine Acetate [NCIt concept]

Keyword's position in hierarchy(ies) :

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