NCIt definition : Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to
catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either
serum or extracellular matrix is often indicative of pathological conditions such
as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis.;
Alternative definition : CDISC: Antigen(s) of the lysosomal proteinase or endopeptidase family and are encoded
by the CTS gene. They can be considered as autoantigens and are commonly associated
with systemic vasculitis, inflammatory rheumatic diseases, autoimmune hepatitis, and
chronic inflammatory bowel diseases.;