Preferred Label : Cathepsin-cleavable NIR Substrate Probe 6QC-NIR;
NCIt synonyms : Fluorescently Quenched Protease Substrate Probe 6QC-NIR;
NCIt definition : A cysteine cathepsin-cleavable near infrared (NIR) substrate probe, that may be used
for cancer imaging purposes using an NIR imaging system. In 6QC-NIR, the cathepsin-activatable
fluorescent probe contains the NIR fluorophore, Dylight 780-B1, linked, via a cathepsin
protease cleavable peptide, with a core Cbz-Phe-Lys peptide sequence, to a fluorescent
quencher, QC-1. Upon administration of 6QC-NIR, the amide bond of the peptide can
be cleaved by cathepsins overexpressed by tumor cells and highly abundant in the tumor
microenvironment (TME). Upon cleavage, the quencher is released, the fluorophore becomes
activated and accumulates in the lysosome. Upon fluorescence imaging, using the da
Vinci Si surgical system, tumor cells expressing cathepsin family proteases can be
detected which allows for visualization of the tumor.;
Molecule name : 6QC NIR; 6QC-NIR;
NCI Metathesaurus CUI : CL972462;
Origin ID : C167240;
UMLS CUI : C5238391;
Semantic type(s)
- concept_is_in_subset
- has_target
