Preferred Label : Cathepsin-targeted Fluorescent Imaging Probe VGT-309;
NCIt synonyms : Cathepsin-activatable Fluorescent Imaging Agent VGT-309; Cathepsin-targeted Fluorescent Imaging Agent VGT-309;
NCIt definition : A fluorescently quenched, cathepsin-activatable, near infrared (NIR) probe containing
the dye indocyanine green (ICG), that may be used for cancer imaging purposes using
an NIR imaging system. Upon administration, cathepsin-targeted fluorescent imaging
probe VGT-309 covalently and irreversibly binds to cathepsins overexpressed by tumor
cells. This displaces the quencher QC-1 and activates the ICG fluorophore. Upon NIR
imaging, cathepsin-expressing tumor cells can be detected which allows for visualization
of the tumor.;
Molecule name : VGT 309; VGT-309;
NCI Metathesaurus CUI : CL1793068;
Origin ID : C188234;
UMLS CUI : C5706466;
Semantic type(s)
- concept_is_in_subset
- has_target
