Preferred Label : Cathepsin-cleavable NIR Substrate Probe 6QC-ICG;
NCIt synonyms : Fluorescently Quenched Protease Substrate Probe 6QC-ICG;
NCIt definition : A fluorescently quenched, cysteine cathepsin-cleavable near infrared (NIR) substrate
probe containing the dye indocyanine green (ICG), that may be used for cancer imaging
purposes using an NIR imaging system. In 6QC-NIR, the cathepsin-activatable fluorescent
probe contains the fluorophore, ICG, linked, via a cathepsin protease cleavable peptide,
with a core Cbz-Phe-Lys peptide sequence, to a fluorescent quencher, QC-1. Upon administration
of 6QC-NIR, the amide bond of the peptide can be cleaved by cathepsin proteases overexpressed
by tumor cells and highly abundant in the tumor microenvironment (TME). Upon proteolysis,
the quencher is released, the fluorophore becomes activated and accumulates in the
lysosome. Upon clinical NIR imaging, using the da Vinci Si surgical system, tumor
cells expressing cathepsin family proteases can be detected which allows for visualization
of the tumor.;
Molecule name : 6QC ICG; 6QC-ICG;
NCI Metathesaurus CUI : CL972463;
Origin ID : C167239;
UMLS CUI : C5238390;
Semantic type(s)
- concept_is_in_subset
- has_target
