Odanacatib - CISMeF

Preferred Label : Odanacatib;

NCIt synonyms : (2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-(((1S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)(1,1'-biphenyl)-4-yl)ethyl)amino)pentanamide;

NCIt definition : An inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption.;

UNII : N673F6W2VH;

InChIKey : FWIVDMJALNEADT-SFTDATJTSA-N;

CAS number : 603139-19-1;

Molecule name : MK0822;

Chemical formula : C25H27F4N3O3S;

Details

Origin ID

C66981;

UMLS CUI

C2351970;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- odanacatib [MeSH concept]
- odanacatib [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Cathepsin [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Bone Resorption Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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