Immunoglobulin Domain

Preferred Label : Immunoglobulin Domain;

NCIt synonyms : Immunoglobulin-Like Domain;

NCIt definition : The major histocompatibility complex (MHC) molecules are made of 2 chains, alpha and beta. In class I, the alpha chain is composed of 3 extracellular domains, a transmembrane region and a cytoplasmic tail while the beta chain is of a single extracellular domain. In class II, both the alpha and the beta chains are composed of 2 extracellular domains, a transmembrane region and a cytoplasmic tail. The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately one hundred amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions, e.g., antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. (InterPro IPR007110);

Details

Origin ID

C13806;

UMLS CUI

C1512665;

Automatic exact mappings (from CISMeF team)
- Immunoglobulin Domains [MeSH Descriptor]
- Immunoglobulin Domains [MeSH concept]
- Immunoglobulin-like Domain [MeSH concept]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- Immunoglobulin Domains [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- Alpha-Protein Kinase 2 [NCIt concept]
- Alpha-Protein Kinase 3 [NCIt concept]
- CD159 Family [NCIt concept]
- CTLA-4 Ligand [NCIt concept]
- Carcinoembryonic Antigen [NCIt concept]
- Fc Receptor [NCIt concept]
- Fc-Gamma Receptor [NCIt concept]
- Fc-Gamma Receptor II [NCIt concept]
- Fc-Gamma Receptor III [NCIt concept]
- Follistatin-Related Protein 5 [NCIt concept]
- Immunoglobulin Family Protein [NCIt concept]
- Immunoglobulin Superfamily Containing Leucine-Rich Repeat Protein [NCIt concept]
- Killer-Cell Immunoglobulin-Like Receptor [NCIt concept]
- Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein Family [NCIt concept]
- Mucosal Addressin Cell Adhesion Molecule 1 [NCIt concept]
- Natural Cytotoxicity Triggering Receptor 1 [NCIt concept]
- Natural Cytotoxicity Triggering Receptor 2 [NCIt concept]
- Natural Cytotoxicity Triggering Receptor 3 [NCIt concept]
- Natural Killer Cell Receptor 2B4 [NCIt concept]
- Obscurin [NCIt concept]
- Plexin-A1 [NCIt concept]
- Rho GDP-Dissociation Inhibitor 1 [NCIt concept]
- Striated Muscle Preferentially Expressed Protein Kinase [NCIt concept]
- Triggering Receptors Expressed on Myeloid Cells Family Protein [NCIt concept]
- V-Set and Immunoglobulin Domain-Containing Protein 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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