Striated Muscle Preferentially Expressed Protein Kinase

Preferred Label : Striated Muscle Preferentially Expressed Protein Kinase;

NCIt synonyms : APEG-1; EC 2.7.11.1; SPEG; Aortic Preferentially Expressed Protein 1; Striated Muscle Enriched Protein Kinase;

NCIt definition : Striated muscle preferentially expressed protein kinase (3267 aa, 354 kDa) is encoded by the human SPEG gene. This protein is involved in cytoskeletal development in myocytes and serine/threonine-protein kinase activity.;

NCIt note : 4 isoforms of striated muscle preferentially expressed protein kinase have been identified, 2 forms are expressed in striated muscle (termed SPEG-alpha and SPEG-beta), 1 in aortic vascular smooth muscle cells (APEG-1) and 1 potentially in aorta and brain (BPEG). The isoforms APEG-1 and BPEG do not include the kinase catalytic domains. (OMIM and UniProt);

Details

Origin ID

C185544;

UMLS CUI

C0391462;

OMIM relation
- Speg complex locus [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- SPEG protein, human [MeSH Supplementary Concept]
- SPEG protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- SPEG Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Striated Muscle Cell [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Myogenesis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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