Fc-Gamma Receptor III

Preferred Label : Fc-Gamma Receptor III;

NCIt synonyms : CD16; FCGR3; FcRIII; Fc Gamma Receptor III; Fc-Gamma RIII; Fc-Gamma Receptor-III; CD16 Antigen; CD16 Protein; FCG3;

NCIt definition : A family of low affinity receptors that bind to the Fc region of gamma immunoglobulin (IgG) monomers and aggregates. These receptors are expressed on the surface of natural killer cells, neutrophils, monocytes and macrophages. IgG binding initiates antibody-dependent cellular cytotoxicity and induces phagocytosis of antigen-antibody complexes.;

Details

Origin ID

C17487;

UMLS CUI

C0108747;

Automatic exact mappings (from CISMeF team)
- CD16 [LOINC component]
- CD16 Ag [LOINC component]
- CD16 cells [LOINC component]
- Fc fragment of IgG receptor IIIa [ORDO Gene]
- Fc fragment of IgG receptor IIIb [ORDO Gene]
- antigens, CD16 [MeSH concept]
- receptors, IgG [MeSH Descriptor]
Biochemical function of gene products
- Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- CD16 [LOINC component]
- CD16 Ag [LOINC component]
- Lymphocyte antigen CD16 (substance) [SNOMED CT concept]
- antigens, CD16 [MeSH concept]
- lymphocyte antigen cd16 [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoglobulin Family Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Bispecific Antibody 2B1 [NCIt concept]
- Bispecific Monoclonal Antibody ASP2074 [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Immunoglobulin Binding Protein [NCIt concept]
- Receptor [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_plays_role_in_biological_process
- Antimicrobial Effect [NCIt concept]
- Cell-Mediated Cytotoxicity [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707 [NCIt concept]

Keyword's position in hierarchy(ies) :

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