Endothelin-1 Receptor

Preferred Label : Endothelin-1 Receptor;

NCIt synonyms : ETA-R; Endothelin A Receptor; ET-A; hET-AR; Endothelin Receptor Type A; EDNRA;

NCIt definition : Endothelin-1 receptor (427 aa, 49 kDa) is encoded by the human EDNRA gene. This protein is a multipass transmembrane protein that is a receptor for endothelin-1 protein and plays a role in G protein-mediated signal transduction.;

NCIt note : An endothelin-1 receptor antagonist, ZD4054, is a drug candidate for treatment of metastatic hormone-resistant prostate cancer.;

Details

Origin ID

C71453;

UMLS CUI

C3853729;

Automatic exact mappings (from CISMeF team)
- Endothelin receptor, type a [OMIM gene]
- Greek letter eta (qualifier value) [SNOMED CT concept]
- endothelin receptor type A [ORDO Gene]
- endothelin receptor type A [HGNC gene]
- receptors, endothelin [MeSH Descriptor]
- receptors, endothelin [MeSH concept]
Currated CISMeF NLP mapping
- receptor, endothelin A [MeSH concept]
- receptor, endothelin a [MeSH Descriptor]
OMIM relation
- Endothelin receptor, type a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EDNRA Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- EGFR-Dependent Endothelin Signaling Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Atrasentan Hydrochloride [NCIt concept]
- Bosentan [NCIt concept]
- Zibotentan [NCIt concept]

Keyword's position in hierarchy(ies) :

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