NCIt definition : An orally available selective antagonist of the endothelin-A (ET-A) receptor with
potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor,
thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of prostate cancer.
It belongs to the family of drugs called endothelin-receptor antagonists.;