Bosentan - CISMeF

Preferred Label : Bosentan;

NCIt synonyms : 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide; Bosentan Monohydrate;

NCIt definition : A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.;

UNII : Q326023R30;

InChIKey : SXTRWVVIEPWAKM-UHFFFAOYSA-N;

CAS number : 157212-55-0;

Drug name : Tracleer;

Molecule name : Ro 47-0203;

Chemical formula : C27H29N5O6S.H2O;

ChEBI ID : CHEBI:31300;

Codes from synonyms : 31871;

Details

Origin ID

C47417;

UMLS CUI

C0252643;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Bosentan [MeSH Descriptor]
- Bosentan (substance) [SNOMED CT concept]
- Product containing bosentan (medicinal product) [SNOMED CT concept]
- bosentan [ATC Code]
- bosentan [Substance BNPC]
Validated automatic mappings to BTNT
- Bosentan monohydrate [SMS substance]
- Bosentan monohydrate (substance) [SNOMED CT concept]
- bosentan [ATC Code]
- bosentan monohydrate [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Endothelin Receptor Type B [NCIt concept]
- Endothelin-1 Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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